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	Fusion Gene Summary
	Fusion Gene Breakpoints
	Tumorigenic MoA (Mechanism of Action) Scenarios of Fusion Geness
	Fusion Genomic Features
	Fusion Gene ORF Annotations
	Fusion Protein Retained/Non-Retained Functional Features
	Fusion Transcript Sequences
	Fusion Protein Sequences
	Personalized Fusion Protein Sequences
	Fusion Gene Expressed Samples
	Related Drugs

Fusion gene:SLC24A3_RIN2 (FusionGDB2 ID:HG57419TG54453)

Fusion Gene Summary for SLC24A3_RIN2

Fusion gene summary

Fusion gene information	Fusion gene name: SLC24A3_RIN2
	Fusion gene ID: hg57419tg54453
		Hgene	Tgene
	Gene symbol	SLC24A3	RIN2
	Gene ID	57419	54453
	Gene name	solute carrier family 24 member 3	Ras and Rab interactor 2
	Synonyms	NCKX3	MACS\|RASSF4
	Cytomap	20p11.23	20p11.23
	Type of gene	protein-coding	protein-coding
	Description	sodium/potassium/calcium exchanger 3Na(+)/K(+)/Ca(2+)-exchange protein 3sodium calcium exchangersolute carrier family 24 (sodium/potassium/calcium exchanger), member 3	ras and Rab interactor 2RAB5 interacting protein 2RAS association (RalGDS/AF-6) domain containing protein JC265RAS association domain family 4RAS inhibitor JC265RAS interaction/interference protein 2
	Modification date	20240305	20240403
	UniProtAcc	.	.
	Ensembl transtripts involved in fusion gene	ENST00000328041,
Fusion gene scores	* DoF score	* DoF score (Degree of Frequency) = # partners X # break points X # disease types 14 X 12 X 8=1344	* DoF score (Degree of Frequency) = # partners X # break points X # disease types 2 X 9 X 5=90
	# samples	28	8
	** MAII score	** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score10) log2(28/134410)=-2.26303440583379 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score10) log2(8/9010)=-0.169925001442312 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: SLC24A3 [Title/Abstract] AND RIN2 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	SLC24A3(19261731)-RIN2(19970649), # samples:1

Fusion gene breakpoints across SLC24A3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across RIN2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Breakpoints for SLC24A3_RIN2

RNA-seq based exon junction arranged fusion gene breakpoints from 8 resources (TCGA, CCLE, cBioPortal, GenBank, ChimerDB, ChimerKB, ChildHoodFusions, and GTEx). For the expressed sample information, go to Fusion Gene Sample section.

Hgene	Hchr	Hbp	Tgene	Tchr	Tbp
SLC24A3	chr20	19261731	RIN2	chr20	19261731
SLC24A3	chr20	19261731	RIN2	chr20	19970650

DNA-seq based exon junction arranged fusion gene breakpoints from dbVar. For the expressed sample information, go to Fusion Gene Sample section.

Hgene	Hchr	Hbp	Tgene	Tchr	Tbp	SV type
SLC24A3	chr20	19618469	RIN2	chr20	19975963	DUP

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Tumorigenic MoA (Mechanism of Action) Scenarios of Fusion Genes for SLC24A3_RIN2

To generate these tumorigenic scenario annotations, we implemented a deduction-first, retrieval-later computational framework. The pipeline first applies rule-guided reasoning across ten core mechanistic categories (M1–M10) derived from fusion gene biology to infer candidate mechanisms, tumorigenic scenarios, targeting points, and targeting backgrounds. To ensure empirical accountability, a governed Python workflow retrieves literature candidates via NCBI E-utilities and Europe PMC using tiered searches. Using JSON Schema-constrained LLM evidence judges (GPT-5.6 Luna and Terra), retrieved articles are evaluated for specificity and confidence without de novo PMID generation. This produces two distinct versions: a strict version restricted to high- or medium-confidence fusion-specific evidence, and an extended version incorporating broader gene-, pathway-, and contextual evidence.

* We have 10 tumorigenic mechanism categories of fusion genes as shown below.

Constitutively Active Kinases, Catalytic Domain Dysregulation, & Transmembrane Ligand Fusions	Aberrant Chimeric Transcription Factor / Fusion Transcription Factor Activity	Epigenetic Reprogramming / Histone Modifier Dysregulation	Chromatin Remodeling Dysregulation	Condensate-Driven Transcriptional Rewiring / LLP	Promoter / Enhancer Hijacking	Dominant-Negative Antagonism	Cell Cycle / Checkpoint Bypass / RNA Processing Dysregulation	Subcellular Mislocalization / Spatial Dysregulation	Nuclear Body / Sub-organellar Architecture Disruption & Differentiation Blockade

* Strict version: Restricted to high- or medium-confidence fusion-specific evidence.

Fusion Gene Name	Mechanism Category	Mechanism PubMed	Tumorigenic Scenarios	Tumorigenic Scenario PubMed	Targeting Points	Targeting PubMed	Mechanism Background	Mechanism Background PubMed
SLC24A3-RIN2	Promoter / Enhancer Hijacking M6		Promoter swap alters NCKX3 calcium exchanger expression alongside RIN2 Ras interaction/endocytic adaptor, coordinating cellular calcium extrusion with endocytic receptor trafficking.		Endocytosis modulators; calcium modulators		Carcinomas and solid tumors

* Extended version: Includes all strict-level fusion evidence plus broader gene-, pathway-, and low-confidence contextual evidence.

Fusion Gene Name	Mechanism Category	Mechanism PubMed	Tumorigenic Scenarios	Tumorigenic Scenario PubMed	Targeting Points	Targeting PubMed	Mechanism Background	Mechanism Background PubMed
SLC24A3-RIN2	Promoter / Enhancer Hijacking M6		Promoter swap alters NCKX3 calcium exchanger expression alongside RIN2 Ras interaction/endocytic adaptor, coordinating cellular calcium extrusion with endocytic receptor trafficking.	Evidence level: Limited indirect gene evidence; Confidence: Low; PMID: 22825554; Title: The R-Ras/RIN2/Rab5 complex controls endothelial cell adhesion and morphogenesis via active integrin endocytosis and Rac signaling.; PMID: 37827343; Title: NAA20 recruits Rin2 and promotes triple-negative breast cancer progression by regulating Rab5A-mediated activation of EGFR signaling.	Endocytosis modulators; calcium modulators		Carcinomas and solid tumors	Evidence level: Indirect gene evidence; Confidence: Medium; PMID: 37827343; Title: NAA20 recruits Rin2 and promotes triple-negative breast cancer progression by regulating Rab5A-mediated activation of EGFR signaling.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	SLC24A3	GO:0006874	intracellular calcium ion homeostasis	26631410
Hgene	SLC24A3	GO:0035725	sodium ion transmembrane transport	26631410
Hgene	SLC24A3	GO:0070588	calcium ion transmembrane transport	26631410
Hgene	SLC24A3	GO:0071805	potassium ion transmembrane transport	26631410

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Fusion Genomic Features for SLC24A3_RIN2

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence) of In-frame fusion genes. FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
SLC24A3	chr20	19261731	+	RIN2	chr20	19970649	+	2.08e-09	1.00e+00

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence) of 5UTR-3CSD fusion genes (N-truncated cases).

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence) of 5CDS-3UTR fusion genes (C-truncated cases).

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of six genomic regulatory feature tracks across a ±5 kb window centered on the fusion breakpoints. We input the breakpoint sequences into AlphaGenome and obtained predicted genome tracks at single-base-pair resolution for each modality by running a single forward pass over the reference sequence. Specifically, for each breakpoint, AlphaGenome processed and returned predicted track data across diverse modalities, which were then averaged across all tracks within each output type and visualized across the ±5 kb window. The left panel shows the 5'-gene breakpoint ±5 kb area, and the right panel shows the 3'-gene breakpoint area, with tracks grouped by category: chromatin accessibility (DNase-seq, ATAC-seq), active transcription (RNA-seq, CAGE), and chromatin binding (ChIP-Histone, ChIP-TF).

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Fusion Gene ORF Annotations for SLC24A3_RIN2

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-3UTR	ENST00000328041	ENST00000484638	SLC24A3	chr20	19261731	+	RIN2	chr20	19970649	+
In-frame	ENST00000328041	ENST00000255006	SLC24A3	chr20	19261731	+	RIN2	chr20	19970649	+
In-frame	ENST00000328041	ENST00000440354	SLC24A3	chr20	19261731	+	RIN2	chr20	19970649	+

ORFfinder Result Based On The Fusion Transcript Sequences of the In-frame Fusion Genes.

Henst	Tenst	Hgene	Hchr	Hbp	Tgene	Tchr	Tbp	Seq length (transcript)	Seq length (peptide)
ENST00000328041	ENST00000255006	SLC24A3	chr20	19261731	RIN2	chr20	19970649	468	494
ENST00000328041	ENST00000440354	SLC24A3	chr20	19261731	RIN2	chr20	19970649	468	431

ORFfinder Result Based On The Fusion Transcript Sequences of the 5UTR-3CDS Fusion Genes for N-Truncated Protein Search.

Henst

Tenst

Hgene

Hchr

Hbp

Tgene

Tchr

Tbp

Seq length
(transcript)

Seq length
(peptide)

ORFfinder Result Based On The Fusion Transcript Sequences of the 5CDS-3UTR Fusion Genes for C-Truncated Protein Search.

Henst

Tenst

Hgene

Hchr

Hbp

Tgene

Tchr

Tbp

Seq length
(transcript)

Seq length
(peptide)

DeepORF Prediction of The Coding Potential Based on The Fusion Transcript Sequence of In-frame Fusion Genes. DeepORF is a Coding Potential Classifier Based on Convolutional Neural Network by Comparing the Real Ribo-seq Data. If the No-coding Score < 0.5 and Coding Score > 0.5, Then The In-frame Fusion Transcript is Predicted as Being Likely Translated.

Henst	Tenst	Hgene	Hchr	Hbp	Tgene	Tchr	Tbp	No-coding score	Coding score
ENST00000328041	ENST00000255006	SLC24A3	chr20	19261731	RIN2	chr20	19970649	8.45e-04	9.99e-01
ENST00000328041	ENST00000440354	SLC24A3	chr20	19261731	RIN2	chr20	19970649	1.63e-04	1.00e+00

DeepORF Prediction of The Coding Potential Based on The Fusion Transcript Sequence of 5UTR-3CDS Fusion Genes (Potential N-Truncated Proteins).

Henst

Tenst

Hgene

Hchr

Hbp

Tgene

Tchr

Tbp

No-coding score

Coding score

DeepORF Prediction of The Coding Potential Based on The Fusion Transcript Sequence of 5CDS-3UTR Fusion Genes (Potential C-Truncated Proteins).

Henst	Tenst	Hgene	Hchr	Hbp	Tgene	Tchr	Tbp	No-coding score	Coding score
ENST00000328041	ENST00000484638	SLC24A3	chr20	19261731	RIN2	chr20	19970649	0.00e+00	6.63e-02

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Fusion Protein Retained/Non-Retained Functional Features for SLC24A3_RIN2

Protein Level Annotation from FGviewer
* Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at download page. Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features (visualization across fusion protein length).

SLC24A3_RIN2_chr20-19261731_chr20-19970649.png

- In-frame and retained protein feature among the 13 regional features (texts).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

RIN2

chr20:19261731

chr20:19970649

ENST00000255006

Q8WYP3

787_878

636.3333333333334

945.0

Domain

Ras-associating

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

SLC24A3

chr20:19261731

chr20:19970649

ENST00000328041

Q9HC58

409_433

90.33333333333333

645.0

Compositional bias

Acidic residues

Hgene

SLC24A3

chr20:19261731

chr20:19970649

ENST00000328041

Q9HC58

405_442

90.33333333333333

645.0

Region

Disordered

Hgene

SLC24A3

chr20:19261731

chr20:19970649

ENST00000328041

Q9HC58

149_189

90.33333333333333

645.0

Repeat

Note=Alpha-1

Hgene

SLC24A3

chr20:19261731

chr20:19970649

ENST00000328041

Q9HC58

518_549

90.33333333333333

645.0

Repeat

Note=Alpha-2

Hgene

SLC24A3

chr20:19261731

chr20:19970649

ENST00000328041

Q9HC58

129_153

90.33333333333333

645.0

Topological domain

Cytoplasmic

Hgene

SLC24A3

chr20:19261731

chr20:19970649

ENST00000328041

Q9HC58

175_182

90.33333333333333

645.0

Topological domain

Extracellular

Hgene

SLC24A3

chr20:19261731

chr20:19970649

ENST00000328041

Q9HC58

204_210

90.33333333333333

645.0

Topological domain

Cytoplasmic

Hgene

SLC24A3

chr20:19261731

chr20:19970649

ENST00000328041

Q9HC58

232_234

90.33333333333333

645.0

Topological domain

Extracellular

Hgene

SLC24A3

chr20:19261731

chr20:19970649

ENST00000328041

Q9HC58

256_484

90.33333333333333

645.0

Topological domain

Cytoplasmic

Hgene

SLC24A3

chr20:19261731

chr20:19970649

ENST00000328041

Q9HC58

45_107

90.33333333333333

645.0

Topological domain

Extracellular

Hgene

SLC24A3

chr20:19261731

chr20:19970649

ENST00000328041

Q9HC58

506_510

90.33333333333333

645.0

Topological domain

Extracellular

Hgene

SLC24A3

chr20:19261731

chr20:19970649

ENST00000328041

Q9HC58

532_549

90.33333333333333

645.0

Topological domain

Cytoplasmic

Hgene

SLC24A3

chr20:19261731

chr20:19970649

ENST00000328041

Q9HC58

571_580

90.33333333333333

645.0

Topological domain

Extracellular

Hgene

SLC24A3

chr20:19261731

chr20:19970649

ENST00000328041

Q9HC58

602_615

90.33333333333333

645.0

Topological domain

Cytoplasmic

Hgene

SLC24A3

chr20:19261731

chr20:19970649

ENST00000328041

Q9HC58

637_644

90.33333333333333

645.0

Topological domain

Extracellular

Hgene

SLC24A3

chr20:19261731

chr20:19970649

ENST00000328041

Q9HC58

108_128

90.33333333333333

645.0

Transmembrane

Helical

Hgene

SLC24A3

chr20:19261731

chr20:19970649

ENST00000328041

Q9HC58

154_174

90.33333333333333

645.0

Transmembrane

Helical

Hgene

SLC24A3

chr20:19261731

chr20:19970649

ENST00000328041

Q9HC58

183_203

90.33333333333333

645.0

Transmembrane

Helical

Hgene

SLC24A3

chr20:19261731

chr20:19970649

ENST00000328041

Q9HC58

211_231

90.33333333333333

645.0

Transmembrane

Helical

Hgene

SLC24A3

chr20:19261731

chr20:19970649

ENST00000328041

Q9HC58

235_255

90.33333333333333

645.0

Transmembrane

Helical

Hgene

SLC24A3

chr20:19261731

chr20:19970649

ENST00000328041

Q9HC58

485_505

90.33333333333333

645.0

Transmembrane

Helical

Hgene

SLC24A3

chr20:19261731

chr20:19970649

ENST00000328041

Q9HC58

511_531

90.33333333333333

645.0

Transmembrane

Helical

Hgene

SLC24A3

chr20:19261731

chr20:19970649

ENST00000328041

Q9HC58

550_570

90.33333333333333

645.0

Transmembrane

Helical

Hgene

SLC24A3

chr20:19261731

chr20:19970649

ENST00000328041

Q9HC58

581_601

90.33333333333333

645.0

Transmembrane

Helical

Hgene

SLC24A3

chr20:19261731

chr20:19970649

ENST00000328041

Q9HC58

616_636

90.33333333333333

645.0

Transmembrane

Helical

Tgene

RIN2

chr20:19261731

chr20:19970649

ENST00000255006

Q8WYP3

306_315

636.3333333333334

945.0

Compositional bias

Pro residues

Tgene

RIN2

chr20:19261731

chr20:19970649

ENST00000255006

Q8WYP3

328_338

636.3333333333334

945.0

Compositional bias

Polar residues

Tgene

RIN2

chr20:19261731

chr20:19970649

ENST00000255006

Q8WYP3

430_441

636.3333333333334

945.0

Compositional bias

Low complexity

Tgene

RIN2

chr20:19261731

chr20:19970649

ENST00000255006

Q8WYP3

618_757

636.3333333333334

945.0

Domain

VPS9

Tgene

RIN2

chr20:19261731

chr20:19970649

ENST00000255006

Q8WYP3

97_190

636.3333333333334

945.0

Domain

SH2

Tgene

RIN2

chr20:19261731

chr20:19970649

ENST00000255006

Q8WYP3

284_361

636.3333333333334

945.0

Region

Disordered

Tgene

RIN2

chr20:19261731

chr20:19970649

ENST00000255006

Q8WYP3

373_442

636.3333333333334

945.0

Region

Disordered

Tgene

RIN2

chr20:19261731

chr20:19970649

ENST00000255006

Q8WYP3

460_481

636.3333333333334

945.0

Region

Disordered

- Retained PPIs in in-frame fusion.

Partner

Hgene

Hbp

Tgene

Tbp

ENST

UniProt

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Hgene

Hbp

Tgene

Tbp

ENST

UniProt

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Fusion Transcript Sequence for SLC24A3_RIN2

In-frame Fusion Transcript Sequences.

>SLC24A3_RIN2_ENST00000328041_ENST00000255006_19261731_19970649 length=2915nt 
 Breakpoint=468nt
GCGACGAGGAGGGCGACGACGAGGAGACGGGCAGCGGCGAGGAGGAGGAAGAGGAGGCGGAGGCGGCGGCCGGGTGGGAGCGCAGCGAGGACGCGCGGCTGCTGCGCGCAGGGCTGCCTCCTGCCGCTGTCCCCGCCGCGGCCGCCCGCG
ACAGGAGCGGCCGCCGCCCGCCGAGGCCGCCGCCCGGCCGCCCGAGGATGCGGCCGTCCGGCGACGAGGACCGCGCGCGTCGCCGCCGCCGCCGCCGCCGCCGGAGGGACCTTCTGCTGAGCCAGCTCTGCTTCCTGGCCTCGGTGGCGC
TGCTGCTCTGGTCGCTGTCGAGCCTGCGAGAGCAGAAGGAGCTTGACCTCATGGACCTCGTAGGGGAAGACAGAAAGTGGATGATGGCGAGGAAGCTGATGCAGGTGAACGACACTCTGACTTCCGAAGATGCCGGACTCCGGAACAGCA
AGAACTGCACCGAACCAGATGTGGTGCTGGAAAAAGCCATGCACAAGTGCATCTTGAAGCCCCTCAAGGGGCACGTGGAGGCCATGCTGAAGGACTTTCACATGGCCGATGGCTCATGGAAGCAACTCAAGGAGAACCTGCAGCTTGTGC
GGCAGAGGAATCCGCAGGAGCTGGGGGTCTTCGCCCCGACCCCTGATTTTGTGGATGTGGAGAAAATCAAAGTCAAGTTCATGACCATGCAGAAGATGTATTCGCCGGAAAAGAAGGTCATGCTGCTGCTGCGGGTCTGCAAGCTCATTT
ACACGGTCATGGAGAACAACTCAGGGAGGATGTATGGCGCTGATGACTTCTTGCCAGTCCTGACCTATGTCATAGCCCAGTGTGACATGCTTGAATTGGACACTGAAATCGAGTACATGATGGAGCTCCTAGACCCATCGCTGTTACATG
GAGAAGGAGGCTATTACTTGACAAGCGCATATGGAGCACTTTCTCTGATAAAGAATTTCCAAGAAGAACAAGCAGCGCGACTGCTCAGCTCAGAAACCAGAGACACCCTGAGGCAGTGGCACAAACGGAGAACCACCAACCGGACCATCC
CCTCTGTGGACGACTTCCAGAATTACCTCCGAGTTGCATTTCAGGAGGTCAACAGTGGTTGCACAGGAAAGACCCTCCTTGTGAGACCTTACATCACCACTGAGGATGTGTGTCAGATCTGCGCTGAGAAGTTCAAGGTGGGGGACCCTG
AGGAGTACAGCCTCTTTCTCTTCGTTGACGAGACATGGCAGCAGCTGGCAGAGGACACTTACCCTCAAAAAATCAAGGCGGAGCTGCACAGCCGACCACAGCCCCACATCTTCCACTTTGTCTACAAACGCATCAAGAACGATCCTTATG
GCATCATTTTCCAGAACGGGGAAGAAGACCTCACCACCTCCTAGAAGACAGGCGGGACTTCCCAGTGGTGCATCCAAAGGGGAGCTGGAAGCCTTGCCTTCCCGCTTCTACATGCTTGAGCTTGAAAAGCAGTCACCTCCTCGGGGACCC
CTCAGTGTAGTGACTAAGCCATCCACAGGCCAACTCGGCCAAGGGCAACTTTAGCCACGCAAGGTAGCTGAGGTTTGTGAAACAGTAGGATTCTCTTTTGGCAATGGAGAATTGCATCTGATGGTTCAAGTGTCCTGAGATTGTTTGCTA
CCTACCCCCAGTCAGGTTCTAGGTTGGCTTACAGGTATGTATATGTGCAGAAGAAACACTTAAGATACAAGTTCTTTTGAATTCAACAGCAGATGCTTGCGATGCAGTGCGTCAGGTGATTCTCACTCCTGTGGATGGCTTCATCCCTGC
CTTCCTTCCTTTCTTTTTCCTTTTTTTTTTTTTTTTTTTTTTTTTTACAAAGAGCCTTCATGTTTTTATATATTTCATAGAAATTTTTATAGCAGTTGCAGGTAAACTGTCAGGATTGGTTTTAAAATATTTTTGTAACTTTAAAATATT
CTATAATTATGCATGTGATTTTAACATTTAATATTCAAAAATAAATCTCTTGCTGGATTTGAGAGTATTGCATTTTTAAAGTCTCTCTTCTGTAACTGGATGTTTTGGCAACTTTGTGGGGAGAGACTGCTGGATTTCTTAAAGCAACGT
ATTCCTGACACTGGCCACAGAATGCCTTTGGAAATCGGATGTACTGTTCTCTTGTTCACGTTTAGTGGTGTTTTGCTGTTTTGTTTTTTAAACAAATGATGCTGAGAATAAGGAGAGAAATGAATGTAGAGAGAGGTAGAGAGAGAAATA
TGAACTCTAACAAAGGACTGAGGAGTGCAGTCTGCTGGTTCAGGCTCTTCAAAAGATGTAGAAAAAGAGATAGAAGGAACCACCTATGCTTAAAATACTGTAAATATGCAGTGAGGTTTGGCAAAATCTATTCCATGTGTGATTTGCTTG
TAGAAACAATTTTGAAAGCCCCTTGAGGAAAATAAAAATCAAGAAGAACACTTTTCTCCCTTTTCCATACAAATTAAAACTTAACAGCATCAAATTATTGGGACCAGAAACCAAGTAATGTATAATGTGGCTTTTGTTGAGTTAAATAAG
ATGCTATATAATGGAGAAGAATTTGAAAATGCACAAAAAAATCAATCTACATTATCAGAACCTGCAGTGAAATTAAACTTATGTTAAATAAAACCAGTTTGCAGGTGCACAAACTATGAGGGTCTTGTATCCACGTAACACAGGTAGTTA
CAAAAACATGTTATTGTACTGTGTAAAGATGCATAGTCATCTCATTTGGTTGGCTTTGTACCTTGTACCTTTTTTAGCCTTGGCTTTTGTTGAACTAGAACCCTCAGCACATACTGTGTTGTACTTTTGTAAATGATTTTTTAAATGGAA
TTTTGCACATAATACATTGTAATACTGTATGATAATCATGTGTGAAAATAATTTTTGAAATATCC

>SLC24A3_RIN2_ENST00000328041_ENST00000440354_19261731_19970649 length=1806nt 
 Breakpoint=468nt
GCGACGAGGAGGGCGACGACGAGGAGACGGGCAGCGGCGAGGAGGAGGAAGAGGAGGCGGAGGCGGCGGCCGGGTGGGAGCGCAGCGAGGACGCGCGGCTGCTGCGCGCAGGGCTGCCTCCTGCCGCTGTCCCCGCCGCGGCCGCCCGCG
ACAGGAGCGGCCGCCGCCCGCCGAGGCCGCCGCCCGGCCGCCCGAGGATGCGGCCGTCCGGCGACGAGGACCGCGCGCGTCGCCGCCGCCGCCGCCGCCGCCGGAGGGACCTTCTGCTGAGCCAGCTCTGCTTCCTGGCCTCGGTGGCGC
TGCTGCTCTGGTCGCTGTCGAGCCTGCGAGAGCAGAAGGAGCTTGACCTCATGGACCTCGTAGGGGAAGACAGAAAGTGGATGATGGCGAGGAAGCTGATGCAGGTGAACGACACTCTGACTTCCGAAGATGCCGGACTCCGGAACAGCA
AGAACTGCACCGAACCAGATGTGGTGCTGGAAAAAGCCATGCACAAGTGCATCTTGAAGCCCCTCAAGGGGCACGTGGAGGCCATGCTGAAGGACTTTCACATGGCCGATGGCTCATGGAAGCAACTCAAGGAGAACCTGCAGCTTGTGC
GGCAGAGGAATCCGCAGGAGCTGGGGGTCTTCGCCCCGACCCCTGATTTTGTGGATGTGGAGAAAATCAAAGTCAAGTTCATGACCATGCAGAAGATGTATTCGCCGGAAAAGAAGGTCATGCTGCTGCTGCGGGTCTGCAAGCTCATTT
ACACGGTCATGGAGAACAACTCAGGGAGGATGTATGGCGCTGATGACTTCTTGCCAGTCCTGACCTATGTCATAGCCCAGTGTGACATGCTTGAATTGGACACTGAAATCGAGTACATGATGGAGCTCCTAGACCCATCGCTGTTACATG
GAGAAGGAGGCTATTACTTGACAAGCGCATATGGAGCACTTTCTCTGATAAAGAATTTCCAAGAAGAACAAGCAGCGCGACTGCTCAGCTCAGAAACCAGAGACACCCTGAGGCAGTGGCACAAACGGAGAACCACCAACCGGACCATCC
CCTCTGTGGACGACTTCCAGAATTACCTCCGAGTTGCATTTCAGGAGGTCAACAGTGGTTGCACAGGAAAGACCCTCCTTGTGAGACCTTACATCACCACTGAGGATGTGTGTCAGATCTGCGCTGAGAAGTTCAAGGTGGGGGACCCTG
AGGAGTACAGCCTCTTTCTCTTCGTTGACGAGACATGGCAGCAGCTGGCAGAGGACACTTACCCTCAAAAAATCAAGGCGGAGCTGCACAGCCGACCACAGCCCCACATCTTCCACTTTGTCTACAAACGCATCAAGAACGATCCTTATG
GCATCATTTTCCAGAACGGGGAAGAAGACCTCACCACCTCCTAGAAGACAGGCGGGACTTCCCAGTGGTGCATCCAAAGGGGAGCTGGAAGCCTTGCCTTCCCGCTTCTACATGCTTGAGCTTGAAAAGCAGTCACCTCCTCGGGGACCC
CTCAGTGTAGTGACTAAGCCATCCACAGGCCAACTCGGCCAAGGGCAACTTTAGCCACGCAAGGTAGCTGAGGTTTGTGAAACAGTAGGATTCTCTTTTGGCAATGGAGAATTGCATCTGATGGTTCAAGTGTCCTGAGATTGTTTGCTA
CCTACCCCCAGTCAGGTTCTAGGTTGGCTTACAGGTATGTATATGTGCAGAAGAAACACTTAAGATACAAGTTCTTTTGAATTCAACAGCAGATGCTTGCGATGCAGTGCGTCAGGTGATTCTCACTCCTGTGGATGGCTTCATCCCTGC
CTTCCT

N-Truncated Transcript (5UTR-3CDS) Sequences

C-Truncated Transcript (5CDS-3UTR) Sequences

>SLC24A3_RIN2_ENST00000328041_ENST00000484638_19261731_19970649 length=468nt 
 Breakpoint=468nt
GCGACGAGGAGGGCGACGACGAGGAGACGGGCAGCGGCGAGGAGGAGGAAGAGGAGGCGGAGGCGGCGGCCGGGTGGGAGCGCAGCGAGGACGCGCGGCTGCTGCGCGCAGGGCTGCCTCCTGCCGCTGTCCCCGCCGCGGCCGCCCGCG
ACAGGAGCGGCCGCCGCCCGCCGAGGCCGCCGCCCGGCCGCCCGAGGATGCGGCCGTCCGGCGACGAGGACCGCGCGCGTCGCCGCCGCCGCCGCCGCCGCCGGAGGGACCTTCTGCTGAGCCAGCTCTGCTTCCTGGCCTCGGTGGCGC
TGCTGCTCTGGTCGCTGTCGAGCCTGCGAGAGCAGAAGGAGCTTGACCTCATGGACCTCGTAGGGGAAGACAGAAAGTGGATGATGGCGAGGAAGCTGATGCAGGTGAACGACACTCTGACTTCCGAAGATGCCGGACTCCGGAACAGCA
AGAACTGCACCGAACCAG

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Fusion Protein Sequence for SLC24A3_RIN2

In-frame Fusion Protein Sequences.

>SLC24A3_RIN2_ENST00000328041_ENST00000255006_19261731_19970649 length=494nt
MNKPSLPAALPNGCVNYSFLLMMGIGKNTTSKSMEAGSSTEGKYEDEAKHPAFFTLPVVINGGATSSGEQDNEDTELMAIYTTENGIAEKSSLAETLDSTGSLDPQRSDMIYTIEDVPPWYLCIFLGLQHYLTCFSGTIAVPFLLADAMC
VGYDQWATSQLIGTIFFCVGITTLLQTTFGCRTIFLVLLFSQYARNVKFPLPIYKSKKGWTAYKLQLFKMFPIILAILVSWLLCFIFTVTDVFPPDSTKYGFYARTDARQGVLLVAPWFKVPYPFQWGLPTVSAAGVIGMLSAVVASIIE
SIGDYYACARLSCAPPPPIHAINRGIFVEGLSCVLDGIFGTGNGSTSSSPNIGVLGITKADLNTNIEDEGSSFYGVSSQYESPENMIITCSTKVCSFGKQVVEKVETEYARYENGHYSYRIHRSPLCEYMINFIHKLKHLPEKYMMNSVL
ENFTILQVVTNRDTQETLLCIAYVFEVSASEHGAQHHIYRLVKE

>SLC24A3_RIN2_ENST00000328041_ENST00000440354_19261731_19970649 length=431nt
MLRAGLPPAAVPAAAARDRSGRRPPRPPPGRPRMRPSGDEDRARRRRRRRRRRDLLLSQLCFLASVALLLWSLSSLREQKELDLMDLVGEDRKWMMARKLMQVNDTLTSEDAGLRNSKNCTEPDVVLEKAMHKCILKPLKGHVEAMLKDF
HMADGSWKQLKENLQLVRQRNPQELGVFAPTPDFVDVEKIKVKFMTMQKMYSPEKKVMLLLRVCKLIYTVMENNSGRMYGADDFLPVLTYVIAQCDMLELDTEIEYMMELLDPSLLHGEGGYYLTSAYGALSLIKNFQEEQAARLLSSET
RDTLRQWHKRRTTNRTIPSVDDFQNYLRVAFQEVNSGCTGKTLLVRPYITTEDVCQICAEKFKVGDPEEYSLFLFVDETWQQLAEDTYPQKIKAELHSRPQPHIFHFVYKRIKNDPYGIIFQNGEEDLTTS

N-Truncated Protein (5UTR-3CDS) Sequences

C-Truncated Protein (5CDS-3UTR) Sequences

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Personalized Fusion Protein Sequence for SLC24A3_RIN2

TCGA Kinase/DNA-binding Domain Mutated Fusion Protein Sequences

Num

Gene Group

Domain Loci

Fusion Protein ID

Fusion Gene Name

Partner

Mutated Residue in WT Protein

Seq. Length

Mutated Residue in Fusion Protein

CCLE Kinase/DNA-binding Domain Mutated Fusion Protein Sequences

Num

Gene Group

Domain Loci

Fusion Protein ID

Fusion Gene Name

Partner

Mutated Residue in WT Protein

Seq. Length

Mutated Residue in Fusion Protein

TCGA All Mutated Fusion Protein Sequences

>SLC24A3_RIN2_ENST00000328041_ENST00000440354_19261731_19970649_3-gene_p.A744T_431_A280T length=431AA
MLRAGLPPAAVPAAAARDRSGRRPPRPPPGRPRMRPSGDEDRARRRRRRRRRRDLLLSQLCFLASVALLLWSLSSLREQKELDLMDLVGEDRKWMMARKLMQVNDTLTSEDAGLRNSKNCTEPDVVLEKAMHKCILKPLKGHVEAMLKDF
HMADGSWKQLKENLQLVRQRNPQELGVFAPTPDFVDVEKIKVKFMTMQKMYSPEKKVMLLLRVCKLIYTVMENNSGRMYGADDFLPVLTYVIAQCDMLELDTEIEYMMELLDPSLLHGEGGYYLTSAYGTLSLIKNFQEEQAARLLSSET
RDTLRQWHKRRTTNRTIPSVDDFQNYLRVAFQEVNSGCTGKTLLVRPYITTEDVCQICAEKFKVGDPEEYSLFLFVDETWQQLAEDTYPQKIKAELHSRPQPHIFHFVYKRIKNDPYGIIFQNGEEDLTTS

>SLC24A3_RIN2_ENST00000328041_ENST00000440354_19261731_19970649_5-gene_p.G80V_431_G113V length=431AA
MLRAGLPPAAVPAAAARDRSGRRPPRPPPGRPRMRPSGDEDRARRRRRRRRRRDLLLSQLCFLASVALLLWSLSSLREQKELDLMDLVGEDRKWMMARKLMQVNDTLTSEDAVLRNSKNCTEPDVVLEKAMHKCILKPLKGHVEAMLKDF
HMADGSWKQLKENLQLVRQRNPQELGVFAPTPDFVDVEKIKVKFMTMQKMYSPEKKVMLLLRVCKLIYTVMENNSGRMYGADDFLPVLTYVIAQCDMLELDTEIEYMMELLDPSLLHGEGGYYLTSAYGALSLIKNFQEEQAARLLSSET
RDTLRQWHKRRTTNRTIPSVDDFQNYLRVAFQEVNSGCTGKTLLVRPYITTEDVCQICAEKFKVGDPEEYSLFLFVDETWQQLAEDTYPQKIKAELHSRPQPHIFHFVYKRIKNDPYGIIFQNGEEDLTTS

>SLC24A3_RIN2_ENST00000328041_ENST00000440354_19261731_19970649_3-gene_p.D696V_431_D232V length=431AA
MLRAGLPPAAVPAAAARDRSGRRPPRPPPGRPRMRPSGDEDRARRRRRRRRRRDLLLSQLCFLASVALLLWSLSSLREQKELDLMDLVGEDRKWMMARKLMQVNDTLTSEDAGLRNSKNCTEPDVVLEKAMHKCILKPLKGHVEAMLKDF
HMADGSWKQLKENLQLVRQRNPQELGVFAPTPDFVDVEKIKVKFMTMQKMYSPEKKVMLLLRVCKLIYTVMENNSGRMYGAVDFLPVLTYVIAQCDMLELDTEIEYMMELLDPSLLHGEGGYYLTSAYGALSLIKNFQEEQAARLLSSET
RDTLRQWHKRRTTNRTIPSVDDFQNYLRVAFQEVNSGCTGKTLLVRPYITTEDVCQICAEKFKVGDPEEYSLFLFVDETWQQLAEDTYPQKIKAELHSRPQPHIFHFVYKRIKNDPYGIIFQNGEEDLTTS

>SLC24A3_RIN2_ENST00000328041_ENST00000440354_19261731_19970649_3-gene_p.L729F_431_L265F length=431AA
MLRAGLPPAAVPAAAARDRSGRRPPRPPPGRPRMRPSGDEDRARRRRRRRRRRDLLLSQLCFLASVALLLWSLSSLREQKELDLMDLVGEDRKWMMARKLMQVNDTLTSEDAGLRNSKNCTEPDVVLEKAMHKCILKPLKGHVEAMLKDF
HMADGSWKQLKENLQLVRQRNPQELGVFAPTPDFVDVEKIKVKFMTMQKMYSPEKKVMLLLRVCKLIYTVMENNSGRMYGADDFLPVLTYVIAQCDMLELDTEIEYMMELLDPSFLHGEGGYYLTSAYGALSLIKNFQEEQAARLLSSET
RDTLRQWHKRRTTNRTIPSVDDFQNYLRVAFQEVNSGCTGKTLLVRPYITTEDVCQICAEKFKVGDPEEYSLFLFVDETWQQLAEDTYPQKIKAELHSRPQPHIFHFVYKRIKNDPYGIIFQNGEEDLTTS

>SLC24A3_RIN2_ENST00000328041_ENST00000440354_19261731_19970649_5-gene_p.L24M_431_L57M length=431AA
MLRAGLPPAAVPAAAARDRSGRRPPRPPPGRPRMRPSGDEDRARRRRRRRRRRDLLMSQLCFLASVALLLWSLSSLREQKELDLMDLVGEDRKWMMARKLMQVNDTLTSEDAGLRNSKNCTEPDVVLEKAMHKCILKPLKGHVEAMLKDF
HMADGSWKQLKENLQLVRQRNPQELGVFAPTPDFVDVEKIKVKFMTMQKMYSPEKKVMLLLRVCKLIYTVMENNSGRMYGADDFLPVLTYVIAQCDMLELDTEIEYMMELLDPSLLHGEGGYYLTSAYGALSLIKNFQEEQAARLLSSET
RDTLRQWHKRRTTNRTIPSVDDFQNYLRVAFQEVNSGCTGKTLLVRPYITTEDVCQICAEKFKVGDPEEYSLFLFVDETWQQLAEDTYPQKIKAELHSRPQPHIFHFVYKRIKNDPYGIIFQNGEEDLTTS

>SLC24A3_RIN2_ENST00000328041_ENST00000440354_19261731_19970649_5-gene_p.R82Q_431_R115Q length=431AA
MLRAGLPPAAVPAAAARDRSGRRPPRPPPGRPRMRPSGDEDRARRRRRRRRRRDLLLSQLCFLASVALLLWSLSSLREQKELDLMDLVGEDRKWMMARKLMQVNDTLTSEDAGLQNSKNCTEPDVVLEKAMHKCILKPLKGHVEAMLKDF
HMADGSWKQLKENLQLVRQRNPQELGVFAPTPDFVDVEKIKVKFMTMQKMYSPEKKVMLLLRVCKLIYTVMENNSGRMYGADDFLPVLTYVIAQCDMLELDTEIEYMMELLDPSLLHGEGGYYLTSAYGALSLIKNFQEEQAARLLSSET
RDTLRQWHKRRTTNRTIPSVDDFQNYLRVAFQEVNSGCTGKTLLVRPYITTEDVCQICAEKFKVGDPEEYSLFLFVDETWQQLAEDTYPQKIKAELHSRPQPHIFHFVYKRIKNDPYGIIFQNGEEDLTTS

>SLC24A3_RIN2_ENST00000328041_ENST00000440354_19261731_19970649_5-gene_p.E89K_431_E122K length=431AA
MLRAGLPPAAVPAAAARDRSGRRPPRPPPGRPRMRPSGDEDRARRRRRRRRRRDLLLSQLCFLASVALLLWSLSSLREQKELDLMDLVGEDRKWMMARKLMQVNDTLTSEDAGLRNSKNCTKPDVVLEKAMHKCILKPLKGHVEAMLKDF
HMADGSWKQLKENLQLVRQRNPQELGVFAPTPDFVDVEKIKVKFMTMQKMYSPEKKVMLLLRVCKLIYTVMENNSGRMYGADDFLPVLTYVIAQCDMLELDTEIEYMMELLDPSLLHGEGGYYLTSAYGALSLIKNFQEEQAARLLSSET
RDTLRQWHKRRTTNRTIPSVDDFQNYLRVAFQEVNSGCTGKTLLVRPYITTEDVCQICAEKFKVGDPEEYSLFLFVDETWQQLAEDTYPQKIKAELHSRPQPHIFHFVYKRIKNDPYGIIFQNGEEDLTTS

>SLC24A3_RIN2_ENST00000328041_ENST00000440354_19261731_19970649_5-gene_p.R82W_431_R115W length=431AA
MLRAGLPPAAVPAAAARDRSGRRPPRPPPGRPRMRPSGDEDRARRRRRRRRRRDLLLSQLCFLASVALLLWSLSSLREQKELDLMDLVGEDRKWMMARKLMQVNDTLTSEDAGLWNSKNCTEPDVVLEKAMHKCILKPLKGHVEAMLKDF
HMADGSWKQLKENLQLVRQRNPQELGVFAPTPDFVDVEKIKVKFMTMQKMYSPEKKVMLLLRVCKLIYTVMENNSGRMYGADDFLPVLTYVIAQCDMLELDTEIEYMMELLDPSLLHGEGGYYLTSAYGALSLIKNFQEEQAARLLSSET
RDTLRQWHKRRTTNRTIPSVDDFQNYLRVAFQEVNSGCTGKTLLVRPYITTEDVCQICAEKFKVGDPEEYSLFLFVDETWQQLAEDTYPQKIKAELHSRPQPHIFHFVYKRIKNDPYGIIFQNGEEDLTTS

>SLC24A3_RIN2_ENST00000328041_ENST00000440354_19261731_19970649_5-gene_p.R82W_431_R115W length=431AA
MLRAGLPPAAVPAAAARDRSGRRPPRPPPGRPRMRPSGDEDRARRRRRRRRRRDLLLSQLCFLASVALLLWSLSSLREQKELDLMDLVGEDRKWMMARKLMQVNDTLTSEDAGLWNSKNCTEPDVVLEKAMHKCILKPLKGHVEAMLKDF
HMADGSWKQLKENLQLVRQRNPQELGVFAPTPDFVDVEKIKVKFMTMQKMYSPEKKVMLLLRVCKLIYTVMENNSGRMYGADDFLPVLTYVIAQCDMLELDTEIEYMMELLDPSLLHGEGGYYLTSAYGALSLIKNFQEEQAARLLSSET
RDTLRQWHKRRTTNRTIPSVDDFQNYLRVAFQEVNSGCTGKTLLVRPYITTEDVCQICAEKFKVGDPEEYSLFLFVDETWQQLAEDTYPQKIKAELHSRPQPHIFHFVYKRIKNDPYGIIFQNGEEDLTTS

>SLC24A3_RIN2_ENST00000328041_ENST00000440354_19261731_19970649_5-gene_p.R82Q_431_R115Q length=431AA
MLRAGLPPAAVPAAAARDRSGRRPPRPPPGRPRMRPSGDEDRARRRRRRRRRRDLLLSQLCFLASVALLLWSLSSLREQKELDLMDLVGEDRKWMMARKLMQVNDTLTSEDAGLQNSKNCTEPDVVLEKAMHKCILKPLKGHVEAMLKDF
HMADGSWKQLKENLQLVRQRNPQELGVFAPTPDFVDVEKIKVKFMTMQKMYSPEKKVMLLLRVCKLIYTVMENNSGRMYGADDFLPVLTYVIAQCDMLELDTEIEYMMELLDPSLLHGEGGYYLTSAYGALSLIKNFQEEQAARLLSSET
RDTLRQWHKRRTTNRTIPSVDDFQNYLRVAFQEVNSGCTGKTLLVRPYITTEDVCQICAEKFKVGDPEEYSLFLFVDETWQQLAEDTYPQKIKAELHSRPQPHIFHFVYKRIKNDPYGIIFQNGEEDLTTS

>SLC24A3_RIN2_ENST00000328041_ENST00000440354_19261731_19970649_3-gene_p.M610I_431_M146I length=431AA
MLRAGLPPAAVPAAAARDRSGRRPPRPPPGRPRMRPSGDEDRARRRRRRRRRRDLLLSQLCFLASVALLLWSLSSLREQKELDLMDLVGEDRKWMMARKLMQVNDTLTSEDAGLRNSKNCTEPDVVLEKAMHKCILKPLKGHVEAILKDF
HMADGSWKQLKENLQLVRQRNPQELGVFAPTPDFVDVEKIKVKFMTMQKMYSPEKKVMLLLRVCKLIYTVMENNSGRMYGADDFLPVLTYVIAQCDMLELDTEIEYMMELLDPSLLHGEGGYYLTSAYGALSLIKNFQEEQAARLLSSET
RDTLRQWHKRRTTNRTIPSVDDFQNYLRVAFQEVNSGCTGKTLLVRPYITTEDVCQICAEKFKVGDPEEYSLFLFVDETWQQLAEDTYPQKIKAELHSRPQPHIFHFVYKRIKNDPYGIIFQNGEEDLTTS

>SLC24A3_RIN2_ENST00000328041_ENST00000440354_19261731_19970649_5-gene_p.E89K_431_E122K length=431AA
MLRAGLPPAAVPAAAARDRSGRRPPRPPPGRPRMRPSGDEDRARRRRRRRRRRDLLLSQLCFLASVALLLWSLSSLREQKELDLMDLVGEDRKWMMARKLMQVNDTLTSEDAGLRNSKNCTKPDVVLEKAMHKCILKPLKGHVEAMLKDF
HMADGSWKQLKENLQLVRQRNPQELGVFAPTPDFVDVEKIKVKFMTMQKMYSPEKKVMLLLRVCKLIYTVMENNSGRMYGADDFLPVLTYVIAQCDMLELDTEIEYMMELLDPSLLHGEGGYYLTSAYGALSLIKNFQEEQAARLLSSET
RDTLRQWHKRRTTNRTIPSVDDFQNYLRVAFQEVNSGCTGKTLLVRPYITTEDVCQICAEKFKVGDPEEYSLFLFVDETWQQLAEDTYPQKIKAELHSRPQPHIFHFVYKRIKNDPYGIIFQNGEEDLTTS

>SLC24A3_RIN2_ENST00000328041_ENST00000440354_19261731_19970649_3-gene_p.M721V_431_M257V length=431AA
MLRAGLPPAAVPAAAARDRSGRRPPRPPPGRPRMRPSGDEDRARRRRRRRRRRDLLLSQLCFLASVALLLWSLSSLREQKELDLMDLVGEDRKWMMARKLMQVNDTLTSEDAGLRNSKNCTEPDVVLEKAMHKCILKPLKGHVEAMLKDF
HMADGSWKQLKENLQLVRQRNPQELGVFAPTPDFVDVEKIKVKFMTMQKMYSPEKKVMLLLRVCKLIYTVMENNSGRMYGADDFLPVLTYVIAQCDMLELDTEIEYVMELLDPSLLHGEGGYYLTSAYGALSLIKNFQEEQAARLLSSET
RDTLRQWHKRRTTNRTIPSVDDFQNYLRVAFQEVNSGCTGKTLLVRPYITTEDVCQICAEKFKVGDPEEYSLFLFVDETWQQLAEDTYPQKIKAELHSRPQPHIFHFVYKRIKNDPYGIIFQNGEEDLTTS

>SLC24A3_RIN2_ENST00000328041_ENST00000440354_19261731_19970649_5-gene_p.W61L_431_W94L length=431AA
MLRAGLPPAAVPAAAARDRSGRRPPRPPPGRPRMRPSGDEDRARRRRRRRRRRDLLLSQLCFLASVALLLWSLSSLREQKELDLMDLVGEDRKLMMARKLMQVNDTLTSEDAGLRNSKNCTEPDVVLEKAMHKCILKPLKGHVEAMLKDF
HMADGSWKQLKENLQLVRQRNPQELGVFAPTPDFVDVEKIKVKFMTMQKMYSPEKKVMLLLRVCKLIYTVMENNSGRMYGADDFLPVLTYVIAQCDMLELDTEIEYMMELLDPSLLHGEGGYYLTSAYGALSLIKNFQEEQAARLLSSET
RDTLRQWHKRRTTNRTIPSVDDFQNYLRVAFQEVNSGCTGKTLLVRPYITTEDVCQICAEKFKVGDPEEYSLFLFVDETWQQLAEDTYPQKIKAELHSRPQPHIFHFVYKRIKNDPYGIIFQNGEEDLTTS

>SLC24A3_RIN2_ENST00000328041_ENST00000440354_19261731_19970649_5-gene_p.S84N_431_S117N length=431AA
MLRAGLPPAAVPAAAARDRSGRRPPRPPPGRPRMRPSGDEDRARRRRRRRRRRDLLLSQLCFLASVALLLWSLSSLREQKELDLMDLVGEDRKWMMARKLMQVNDTLTSEDAGLRNNKNCTEPDVVLEKAMHKCILKPLKGHVEAMLKDF
HMADGSWKQLKENLQLVRQRNPQELGVFAPTPDFVDVEKIKVKFMTMQKMYSPEKKVMLLLRVCKLIYTVMENNSGRMYGADDFLPVLTYVIAQCDMLELDTEIEYMMELLDPSLLHGEGGYYLTSAYGALSLIKNFQEEQAARLLSSET
RDTLRQWHKRRTTNRTIPSVDDFQNYLRVAFQEVNSGCTGKTLLVRPYITTEDVCQICAEKFKVGDPEEYSLFLFVDETWQQLAEDTYPQKIKAELHSRPQPHIFHFVYKRIKNDPYGIIFQNGEEDLTTS

>SLC24A3_RIN2_ENST00000328041_ENST00000440354_19261731_19970649_5-gene_p.E77K_431_E110K length=431AA
MLRAGLPPAAVPAAAARDRSGRRPPRPPPGRPRMRPSGDEDRARRRRRRRRRRDLLLSQLCFLASVALLLWSLSSLREQKELDLMDLVGEDRKWMMARKLMQVNDTLTSKDAGLRNSKNCTEPDVVLEKAMHKCILKPLKGHVEAMLKDF
HMADGSWKQLKENLQLVRQRNPQELGVFAPTPDFVDVEKIKVKFMTMQKMYSPEKKVMLLLRVCKLIYTVMENNSGRMYGADDFLPVLTYVIAQCDMLELDTEIEYMMELLDPSLLHGEGGYYLTSAYGALSLIKNFQEEQAARLLSSET
RDTLRQWHKRRTTNRTIPSVDDFQNYLRVAFQEVNSGCTGKTLLVRPYITTEDVCQICAEKFKVGDPEEYSLFLFVDETWQQLAEDTYPQKIKAELHSRPQPHIFHFVYKRIKNDPYGIIFQNGEEDLTTS

>SLC24A3_RIN2_ENST00000328041_ENST00000440354_19261731_19970649_5-gene_p.S41L_431_S74L length=431AA
MLRAGLPPAAVPAAAARDRSGRRPPRPPPGRPRMRPSGDEDRARRRRRRRRRRDLLLSQLCFLASVALLLWSLLSLREQKELDLMDLVGEDRKWMMARKLMQVNDTLTSEDAGLRNSKNCTEPDVVLEKAMHKCILKPLKGHVEAMLKDF
HMADGSWKQLKENLQLVRQRNPQELGVFAPTPDFVDVEKIKVKFMTMQKMYSPEKKVMLLLRVCKLIYTVMENNSGRMYGADDFLPVLTYVIAQCDMLELDTEIEYMMELLDPSLLHGEGGYYLTSAYGALSLIKNFQEEQAARLLSSET
RDTLRQWHKRRTTNRTIPSVDDFQNYLRVAFQEVNSGCTGKTLLVRPYITTEDVCQICAEKFKVGDPEEYSLFLFVDETWQQLAEDTYPQKIKAELHSRPQPHIFHFVYKRIKNDPYGIIFQNGEEDLTTS

>SLC24A3_RIN2_ENST00000328041_ENST00000440354_19261731_19970649_5-gene_p.M52I_431_M85I length=431AA
MLRAGLPPAAVPAAAARDRSGRRPPRPPPGRPRMRPSGDEDRARRRRRRRRRRDLLLSQLCFLASVALLLWSLSSLREQKELDLIDLVGEDRKWMMARKLMQVNDTLTSEDAGLRNSKNCTEPDVVLEKAMHKCILKPLKGHVEAMLKDF
HMADGSWKQLKENLQLVRQRNPQELGVFAPTPDFVDVEKIKVKFMTMQKMYSPEKKVMLLLRVCKLIYTVMENNSGRMYGADDFLPVLTYVIAQCDMLELDTEIEYMMELLDPSLLHGEGGYYLTSAYGALSLIKNFQEEQAARLLSSET
RDTLRQWHKRRTTNRTIPSVDDFQNYLRVAFQEVNSGCTGKTLLVRPYITTEDVCQICAEKFKVGDPEEYSLFLFVDETWQQLAEDTYPQKIKAELHSRPQPHIFHFVYKRIKNDPYGIIFQNGEEDLTTS

>SLC24A3_RIN2_ENST00000328041_ENST00000440354_19261731_19970649_5-gene_p.E89K_431_E122K length=431AA
MLRAGLPPAAVPAAAARDRSGRRPPRPPPGRPRMRPSGDEDRARRRRRRRRRRDLLLSQLCFLASVALLLWSLSSLREQKELDLMDLVGEDRKWMMARKLMQVNDTLTSEDAGLRNSKNCTKPDVVLEKAMHKCILKPLKGHVEAMLKDF
HMADGSWKQLKENLQLVRQRNPQELGVFAPTPDFVDVEKIKVKFMTMQKMYSPEKKVMLLLRVCKLIYTVMENNSGRMYGADDFLPVLTYVIAQCDMLELDTEIEYMMELLDPSLLHGEGGYYLTSAYGALSLIKNFQEEQAARLLSSET
RDTLRQWHKRRTTNRTIPSVDDFQNYLRVAFQEVNSGCTGKTLLVRPYITTEDVCQICAEKFKVGDPEEYSLFLFVDETWQQLAEDTYPQKIKAELHSRPQPHIFHFVYKRIKNDPYGIIFQNGEEDLTTS

>SLC24A3_RIN2_ENST00000328041_ENST00000440354_19261731_19970649_5-gene_p.R17C_431_R50C length=431AA
MLRAGLPPAAVPAAAARDRSGRRPPRPPPGRPRMRPSGDEDRARRRRRRCRRRDLLLSQLCFLASVALLLWSLSSLREQKELDLMDLVGEDRKWMMARKLMQVNDTLTSEDAGLRNSKNCTEPDVVLEKAMHKCILKPLKGHVEAMLKDF
HMADGSWKQLKENLQLVRQRNPQELGVFAPTPDFVDVEKIKVKFMTMQKMYSPEKKVMLLLRVCKLIYTVMENNSGRMYGADDFLPVLTYVIAQCDMLELDTEIEYMMELLDPSLLHGEGGYYLTSAYGALSLIKNFQEEQAARLLSSET
RDTLRQWHKRRTTNRTIPSVDDFQNYLRVAFQEVNSGCTGKTLLVRPYITTEDVCQICAEKFKVGDPEEYSLFLFVDETWQQLAEDTYPQKIKAELHSRPQPHIFHFVYKRIKNDPYGIIFQNGEEDLTTS

>SLC24A3_RIN2_ENST00000328041_ENST00000440354_19261731_19970649_3-gene_p.L724M_431_L260M length=431AA
MLRAGLPPAAVPAAAARDRSGRRPPRPPPGRPRMRPSGDEDRARRRRRRRRRRDLLLSQLCFLASVALLLWSLSSLREQKELDLMDLVGEDRKWMMARKLMQVNDTLTSEDAGLRNSKNCTEPDVVLEKAMHKCILKPLKGHVEAMLKDF
HMADGSWKQLKENLQLVRQRNPQELGVFAPTPDFVDVEKIKVKFMTMQKMYSPEKKVMLLLRVCKLIYTVMENNSGRMYGADDFLPVLTYVIAQCDMLELDTEIEYMMEMLDPSLLHGEGGYYLTSAYGALSLIKNFQEEQAARLLSSET
RDTLRQWHKRRTTNRTIPSVDDFQNYLRVAFQEVNSGCTGKTLLVRPYITTEDVCQICAEKFKVGDPEEYSLFLFVDETWQQLAEDTYPQKIKAELHSRPQPHIFHFVYKRIKNDPYGIIFQNGEEDLTTS

Fusion Protein ID	Sample ID	Mutated Partner	AAchange in WT	Seq. Length	AAchange in Fusion
ENST00000328041_ENST00000440354_19261731_19970649	TCGA-06-5416-01A	3-gene	p.A744T	431	A280T
ENST00000328041_ENST00000440354_19261731_19970649	TCGA-18-3416-01A	5-gene	p.G80V	431	G113V
ENST00000328041_ENST00000440354_19261731_19970649	TCGA-78-7166-01A	3-gene	p.D696V	431	D232V
ENST00000328041_ENST00000440354_19261731_19970649	TCGA-A5-A0G1-01A	3-gene	p.L729F	431	L265F
ENST00000328041_ENST00000440354_19261731_19970649	TCGA-AA-3979-01A	5-gene	p.L24M	431	L57M
ENST00000328041_ENST00000440354_19261731_19970649	TCGA-AJ-A8CV-01A	5-gene	p.R82Q	431	R115Q
ENST00000328041_ENST00000440354_19261731_19970649	TCGA-AP-A056-01A	5-gene	p.E89K	431	E122K
ENST00000328041_ENST00000440354_19261731_19970649	TCGA-AX-A05Y-01A	5-gene	p.R82W	431	R115W
ENST00000328041_ENST00000440354_19261731_19970649	TCGA-AX-A2HD-01A	5-gene	p.R82W	431	R115W
ENST00000328041_ENST00000440354_19261731_19970649	TCGA-BS-A0U5-01A	5-gene	p.R82Q	431	R115Q
ENST00000328041_ENST00000440354_19261731_19970649	TCGA-CA-6717-01A	3-gene	p.M610I	431	M146I
ENST00000328041_ENST00000440354_19261731_19970649	TCGA-DF-A2KU-01A	5-gene	p.E89K	431	E122K
ENST00000328041_ENST00000440354_19261731_19970649	TCGA-DX-A8BV-01A	3-gene	p.M721V	431	M257V
ENST00000328041_ENST00000440354_19261731_19970649	TCGA-EE-A184-06A	5-gene	p.W61L	431	W94L
ENST00000328041_ENST00000440354_19261731_19970649	TCGA-EE-A2GH-06A	5-gene	p.S84N	431	S117N
ENST00000328041_ENST00000440354_19261731_19970649	TCGA-EE-A2MM-06A	5-gene	p.E77K	431	E110K
ENST00000328041_ENST00000440354_19261731_19970649	TCGA-EE-A3J7-06A	5-gene	p.S41L	431	S74L
ENST00000328041_ENST00000440354_19261731_19970649	TCGA-ER-A19T-06A	5-gene	p.M52I	431	M85I
ENST00000328041_ENST00000440354_19261731_19970649	TCGA-FR-A726-01A	5-gene	p.E89K	431	E122K
ENST00000328041_ENST00000440354_19261731_19970649	TCGA-HU-A4GX-01A	5-gene	p.R17C	431	R50C
ENST00000328041_ENST00000440354_19261731_19970649	TCGA-IB-A6UG-01A	3-gene	p.L724M	431	L260M

CCLE All Mutated Fusion Protein Sequences

Fusion Protein ID

Sample ID

Mutated Partner

AAchange in WT

Seq. Length

AAchange in Fusion

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Fusion Gene Exprssed Samples for SLC24A3_RIN2

RNA-seq based fusion gene expressed samples.

Source	Study	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB		ESCA	TCGA-LN-A49O-01A	SLC24A3	chr20	19261731	+	RIN2	chr20	19261731	+
ChimerDB		ESCA	TCGA-LN-A49O	SLC24A3	chr20	19261731	+	RIN2	chr20	19261731	+
WashU		ESCA	TCGA-LN-A49O-01A	SLC24A3	chr20	19261731	+	RIN2	chr20	19970650	+

DNA-seq based fusion gene expressed samples.

Source

Study

Disease

Sample

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

SV type

dbVar

estd214

Unknown_Cell

NA19454

SLC24A3

chr20

19618469

RIN2

chr20

19975963

DUP

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Related Drugs for SLC24A3_RIN2

PubMed Abstract Search With ['A-B' AND 'drug'], ['A::B' AND 'drug']
* For more details on the Studied, Reported, Approved Drugs targeting this fusion gene, Go to FusionPub.

PMID

Fusion Gene Name

Drug

Study Title

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status