Home

Download

Statistics

Examples

About

Contact

	Fusion Gene Summary
	Fusion Gene Breakpoints
	Tumorigenic MoA (Mechanism of Action) Scenarios of Fusion Geness
	Fusion Genomic Features
	Fusion Gene ORF Annotations
	Fusion Protein Retained/Non-Retained Functional Features
	Fusion Transcript Sequences
	Fusion Protein Sequences
	Personalized Fusion Protein Sequences
	Fusion Gene Expressed Samples
	Related Drugs

Fusion gene:USP37_RNF25 (FusionGDB2 ID:HG57695TG64320)

Fusion Gene Summary for USP37_RNF25

Fusion gene summary

Fusion gene information	Fusion gene name: USP37_RNF25
	Fusion gene ID: hg57695tg64320
		Hgene	Tgene
	Gene symbol	USP37	RNF25
	Gene ID	57695	64320
	Gene name	ubiquitin specific peptidase 37	ring finger protein 25
	Synonyms	-	AO7
	Cytomap	2q35	2q35
	Type of gene	protein-coding	protein-coding
	Description	ubiquitin carboxyl-terminal hydrolase 37deubiquitinating enzyme 37tmp_locus_50ubiquitin specific protease 37ubiquitin thioesterase 37ubiquitin thiolesterase 37ubiquitin-specific-processing protease 37	E3 ubiquitin-protein ligase RNF25RING-type E3 ubiquitin transferase RNF25ring finger protein AO7
	Modification date	20240305	20240416
	UniProtAcc	.	.
	Ensembl transtripts involved in fusion gene	ENST00000258399, ENST00000338465, ENST00000415516, ENST00000418019, ENST00000454775, ENST00000475553,
Fusion gene scores	* DoF score	* DoF score (Degree of Frequency) = # partners X # break points X # disease types 9 X 15 X 6=810	* DoF score (Degree of Frequency) = # partners X # break points X # disease types 4 X 2 X 3=24
	# samples	16	6
	** MAII score	** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score10) log2(16/81010)=-2.33985000288462 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score10) log2(6/2410)=1.32192809488736 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0
Context	PubMed: USP37 [Title/Abstract] AND RNF25 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	USP37(219394678)-RNF25(219533402), # samples:1

Fusion gene breakpoints across USP37 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across RNF25 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Top

Fusion Gene Breakpoints for USP37_RNF25

RNA-seq based exon junction arranged fusion gene breakpoints from 8 resources (TCGA, CCLE, cBioPortal, GenBank, ChimerDB, ChimerKB, ChildHoodFusions, and GTEx). For the expressed sample information, go to Fusion Gene Sample section.

Hgene	Hchr	Hbp	Tgene	Tchr	Tbp
USP37	chr2	219394678	RNF25	chr2	219533402
USP37	chr2	219394679	RNF25	chr2	219533402
USP37	chr2	218529956	RNF25	chr2	218668679

DNA-seq based exon junction arranged fusion gene breakpoints from dbVar. For the expressed sample information, go to Fusion Gene Sample section.

Hgene

Hchr

Hbp

Tgene

Tchr

Tbp

SV type

Top

Tumorigenic MoA (Mechanism of Action) Scenarios of Fusion Genes for USP37_RNF25

To generate these tumorigenic scenario annotations, we implemented a deduction-first, retrieval-later computational framework. The pipeline first applies rule-guided reasoning across ten core mechanistic categories (M1–M10) derived from fusion gene biology to infer candidate mechanisms, tumorigenic scenarios, targeting points, and targeting backgrounds. To ensure empirical accountability, a governed Python workflow retrieves literature candidates via NCBI E-utilities and Europe PMC using tiered searches. Using JSON Schema-constrained LLM evidence judges (GPT-5.6 Luna and Terra), retrieved articles are evaluated for specificity and confidence without de novo PMID generation. This produces two distinct versions: a strict version restricted to high- or medium-confidence fusion-specific evidence, and an extended version incorporating broader gene-, pathway-, and contextual evidence.

* We have 10 tumorigenic mechanism categories of fusion genes as shown below.

Constitutively Active Kinases, Catalytic Domain Dysregulation, & Transmembrane Ligand Fusions	Aberrant Chimeric Transcription Factor / Fusion Transcription Factor Activity	Epigenetic Reprogramming / Histone Modifier Dysregulation	Chromatin Remodeling Dysregulation	Condensate-Driven Transcriptional Rewiring / LLP	Promoter / Enhancer Hijacking	Dominant-Negative Antagonism	Cell Cycle / Checkpoint Bypass / RNA Processing Dysregulation	Subcellular Mislocalization / Spatial Dysregulation	Nuclear Body / Sub-organellar Architecture Disruption & Differentiation Blockade

* Strict version: Restricted to high- or medium-confidence fusion-specific evidence.

Fusion Gene Name

Mechanism Category

Mechanism PubMed

Tumorigenic Scenarios

Tumorigenic Scenario PubMed

Targeting Points

Targeting PubMed

Mechanism Background

Mechanism Background PubMed

* Extended version: Includes all strict-level fusion evidence plus broader gene-, pathway-, and low-confidence contextual evidence.

Fusion Gene Name

Mechanism Category

Mechanism PubMed

Tumorigenic Scenarios

Tumorigenic Scenario PubMed

Targeting Points

Targeting PubMed

Mechanism Background

Mechanism Background PubMed

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	USP37	GO:0000082	G1/S transition of mitotic cell cycle	21596315
Hgene	USP37	GO:0016579	protein deubiquitination	14715245
Hgene	USP37	GO:0035871	protein K11-linked deubiquitination	21596315
Hgene	USP37	GO:0071108	protein K48-linked deubiquitination	21596315
Tgene	RNF25	GO:0006511	ubiquitin-dependent protein catabolic process	27863242
Tgene	RNF25	GO:0051092	positive regulation of NF-kappaB transcription factor activity	12748188
Tgene	RNF25	GO:0072344	rescue of stalled ribosome	27863242\|36638793\|37651229\|37951216
Tgene	RNF25	GO:0085020	protein K6-linked ubiquitination	27863242

Top

Fusion Genomic Features for USP37_RNF25

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence) of In-frame fusion genes. FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
USP37	chr2	219394678	-	RNF25	chr2	219533402	-	2.54e-08	1.00e+00

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence) of 5UTR-3CSD fusion genes (N-truncated cases).

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence) of 5CDS-3UTR fusion genes (C-truncated cases).

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of six genomic regulatory feature tracks across a ±5 kb window centered on the fusion breakpoints. We input the breakpoint sequences into AlphaGenome and obtained predicted genome tracks at single-base-pair resolution for each modality by running a single forward pass over the reference sequence. Specifically, for each breakpoint, AlphaGenome processed and returned predicted track data across diverse modalities, which were then averaged across all tracks within each output type and visualized across the ±5 kb window. The left panel shows the 5'-gene breakpoint ±5 kb area, and the right panel shows the 3'-gene breakpoint area, with tracks grouped by category: chromatin accessibility (DNase-seq, ATAC-seq), active transcription (RNA-seq, CAGE), and chromatin binding (ChIP-Histone, ChIP-TF).

Top

Fusion Gene ORF Annotations for USP37_RNF25

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
Frame-shift	ENST00000258399	ENST00000295704	USP37	chr2	219394678	-	RNF25	chr2	219533402	-
Frame-shift	ENST00000338465	ENST00000295704	USP37	chr2	219394678	-	RNF25	chr2	219533402	-
Frame-shift	ENST00000415516	ENST00000295704	USP37	chr2	219394678	-	RNF25	chr2	219533402	-
Frame-shift	ENST00000418019	ENST00000295704	USP37	chr2	219394678	-	RNF25	chr2	219533402	-
In-frame	ENST00000454775	ENST00000295704	USP37	chr2	219394678	-	RNF25	chr2	219533402	-

ORFfinder Result Based On The Fusion Transcript Sequences of the In-frame Fusion Genes.

Henst

Tenst

Hgene

Hchr

Hbp

Tgene

Tchr

Tbp

Seq length
(transcript)

Seq length
(peptide)

ORFfinder Result Based On The Fusion Transcript Sequences of the 5UTR-3CDS Fusion Genes for N-Truncated Protein Search.

Henst

Tenst

Hgene

Hchr

Hbp

Tgene

Tchr

Tbp

Seq length
(transcript)

Seq length
(peptide)

ORFfinder Result Based On The Fusion Transcript Sequences of the 5CDS-3UTR Fusion Genes for C-Truncated Protein Search.

Henst

Tenst

Hgene

Hchr

Hbp

Tgene

Tchr

Tbp

Seq length
(transcript)

Seq length
(peptide)

DeepORF Prediction of The Coding Potential Based on The Fusion Transcript Sequence of In-frame Fusion Genes. DeepORF is a Coding Potential Classifier Based on Convolutional Neural Network by Comparing the Real Ribo-seq Data. If the No-coding Score < 0.5 and Coding Score > 0.5, Then The In-frame Fusion Transcript is Predicted as Being Likely Translated.

Henst	Tenst	Hgene	Hchr	Hbp	Tgene	Tchr	Tbp	No-coding score	Coding score
ENST00000454775	ENST00000295704	USP37	chr2	219394678	RNF25	chr2	219533402	3.71e-04	1.00e+00

DeepORF Prediction of The Coding Potential Based on The Fusion Transcript Sequence of 5UTR-3CDS Fusion Genes (Potential N-Truncated Proteins).

Henst

Tenst

Hgene

Hchr

Hbp

Tgene

Tchr

Tbp

No-coding score

Coding score

DeepORF Prediction of The Coding Potential Based on The Fusion Transcript Sequence of 5CDS-3UTR Fusion Genes (Potential C-Truncated Proteins).

Henst

Tenst

Hgene

Hchr

Hbp

Tgene

Tchr

Tbp

No-coding score

Coding score

Top

Fusion Protein Retained/Non-Retained Functional Features for USP37_RNF25

Protein Level Annotation from FGviewer
* Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at download page. Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features (visualization across fusion protein length).

USP37_RNF25_chr2-219394678_chr2-219533402.png

- In-frame and retained protein feature among the 13 regional features (texts).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

USP37

chr2:219394678

chr2:219533402

ENST00000454775

Q86T82

135_145

287.6666666666667

980.0

Compositional bias

Polar residues

Hgene

USP37

chr2:219394678

chr2:219533402

ENST00000454775

Q86T82

183_198

287.6666666666667

980.0

Compositional bias

Low complexity

Hgene

USP37

chr2:219394678

chr2:219533402

ENST00000454775

Q86T82

243_257

287.6666666666667

980.0

Compositional bias

Basic and acidic residues

Hgene

USP37

chr2:219394678

chr2:219533402

ENST00000454775

Q86T82

160_168

287.6666666666667

980.0

Motif

Note=D-box 3

Hgene

USP37

chr2:219394678

chr2:219533402

ENST00000454775

Q86T82

71_79

287.6666666666667

980.0

Motif

Note=D-box 1

Hgene

USP37

chr2:219394678

chr2:219533402

ENST00000454775

Q86T82

96_105

287.6666666666667

980.0

Motif

Note=D-box 2

Hgene

USP37

chr2:219394678

chr2:219533402

ENST00000454775

Q86T82

110_153

287.6666666666667

980.0

Region

Disordered

Tgene

RNF25

chr2:219394678

chr2:219533402

ENST00000295704

Q96BH1

282_303

13.666666666666666

460.0

Compositional bias

Polar residues

Tgene

RNF25

chr2:219394678

chr2:219533402

ENST00000295704

Q96BH1

349_370

13.666666666666666

460.0

Compositional bias

Basic and acidic residues

Tgene

RNF25

chr2:219394678

chr2:219533402

ENST00000295704

Q96BH1

378_389

13.666666666666666

460.0

Compositional bias

Basic and acidic residues

Tgene

RNF25

chr2:219394678

chr2:219533402

ENST00000295704

Q96BH1

413_424

13.666666666666666

460.0

Compositional bias

Basic and acidic residues

Tgene

RNF25

chr2:219394678

chr2:219533402

ENST00000295704

Q96BH1

446_459

13.666666666666666

460.0

Compositional bias

Basic and acidic residues

Tgene

RNF25

chr2:219394678

chr2:219533402

ENST00000295704

Q96BH1

18_128

13.666666666666666

460.0

Domain

RWD

Tgene

RNF25

chr2:219394678

chr2:219533402

ENST00000295704

Q96BH1

268_309

13.666666666666666

460.0

Region

Disordered

Tgene

RNF25

chr2:219394678

chr2:219533402

ENST00000295704

Q96BH1

322_459

13.666666666666666

460.0

Region

Disordered

Tgene

RNF25

chr2:219394678

chr2:219533402

ENST00000295704

Q96BH1

135_202

13.666666666666666

460.0

Zinc finger

RING-type

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

USP37

chr2:219394678

chr2:219533402

ENST00000454775

Q86T82

281_298

287.6666666666667

980.0

Compositional bias

Polar residues

Hgene

USP37

chr2:219394678

chr2:219533402

ENST00000454775

Q86T82

681_695

287.6666666666667

980.0

Compositional bias

Basic and acidic residues

Hgene

USP37

chr2:219394678

chr2:219533402

ENST00000454775

Q86T82

719_732

287.6666666666667

980.0

Compositional bias

Basic and acidic residues

Hgene

USP37

chr2:219394678

chr2:219533402

ENST00000454775

Q86T82

774_786

287.6666666666667

980.0

Compositional bias

Basic and acidic residues

Hgene

USP37

chr2:219394678

chr2:219533402

ENST00000454775

Q86T82

341_951

287.6666666666667

980.0

Domain

Note=USP

Hgene

USP37

chr2:219394678

chr2:219533402

ENST00000454775

Q86T82

704_723

287.6666666666667

980.0

Domain

UIM 1

Hgene

USP37

chr2:219394678

chr2:219533402

ENST00000454775

Q86T82

806_825

287.6666666666667

980.0

Domain

UIM 2

Hgene

USP37

chr2:219394678

chr2:219533402

ENST00000454775

Q86T82

828_847

287.6666666666667

980.0

Domain

UIM 3

Hgene

USP37

chr2:219394678

chr2:219533402

ENST00000454775

Q86T82

183_304

287.6666666666667

980.0

Region

Disordered

Hgene

USP37

chr2:219394678

chr2:219533402

ENST00000454775

Q86T82

673_701

287.6666666666667

980.0

Region

Disordered

Hgene

USP37

chr2:219394678

chr2:219533402

ENST00000454775

Q86T82

719_795

287.6666666666667

980.0

Region

Disordered

- Retained PPIs in in-frame fusion.

Partner

Hgene

Hbp

Tgene

Tbp

ENST

UniProt

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Hgene

Hbp

Tgene

Tbp

ENST

UniProt

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Fusion Transcript Sequence for USP37_RNF25

In-frame Fusion Transcript Sequences.

>USP37_RNF25_ENST00000454775_ENST00000295704_219394678_219533402 length=2712nt 
 Breakpoint=1280nt
ATCAGCCGCTCTCCCTGACTAGGGGTAGCTAGCGGCCTCCCTCCTTTGGGTTCGGTATCCCTACTTCCATTACCCTCGGCTCCTCCCACTCCTCGCGGGCTCCGTGCTTTCCGCGGGTCTGTCCGGGGGCTCCGGACCCTCGGCGCAGCT
GAGTTGATGGCTTCCGGAGAACTGGCATAGCTGCAGAATATGAGTAGTGTCCCAAGAAGAGTGCTTTGCCTTTGGCACAAGGATCAGAATAAAGGTGAATTGCTATTACATAGGGTTTTTCGGTAAAAGTCACTGAAAATTATTTGCCAT
ACAGTAACCAGAGACCTCCAACTAGGGGCCCCCAAACTGTATCCTGCCTGTAGAACCTGCCAGGTAAAGGTATATTTTTGCTTTTTAATTTAGCCAGAAGCAATTTTTAAAGAAAATATGTCTCCTCTGAAGATACATGGTCCTATCAGA
ATTCGAAGTATGCAGACTGGGATTACAAAGTGGAAAGAAGGATCCTTTGAAATTGTAGAAAAAGAGAATAAAGTCAGCCTAGTAGTTCACTACAATACTGGAGGAATTCCAAGGATATTTCAGCTAAGTCATAACATTAAAAATGTGGTG
CTTCGACCCAGTGGAGCGAAACAAAGCCGCCTAATGTTAACTCTGCAAGATAACAGCTTCTTGTCTATTGACAAAGTACCAAGTAAGGATGCAGAGGAAATGAGGTTGTTTCTAGATGCAGTCCATCAAAACAGACTTCCTGCAGCCATG
AAACCGTCTCAGGGGTCTGGTAGTTTTGGAGCCATTCTGGGCAGCAGGACCTCACAGAAGGAAACCAGCAGGCAGCTTTCTTACTCAGACAATCAGGCTTCTGCAAAAAGAGGAAGTTTGGAAACTAAAGATGATATTCCATTTCGAAAA
GTTCTTGGTAATCCGGGTAGAGGATCGATTAAGACTGTAGCAGGAAGTGGAATAGCTCGGACGATTCCTTCTTTGACATCTACTTCAACACCTCTTAGATCAGGGTTGCTAGAAAATCGTACTGAAAAGAGGAAAAGAATGATATCAACT
GGCTCAGAATTGAATGAAGATTACCCTAAGGAAAATGATTCATCATCGAACAACAAGGCCATGACAGATCCCTCCAGAAAGTATTTAACCAGCAGTAGAGAAAAGCAGCTGAGTTTGAAACAGTCAGAAGAGAATAGGACATCAGGGCTT
TTACCTTTACAGTCATCATCCTTTTATGGTAGCAGAGCTGGATCCAAGGAACACTCTTCTGGTGGCACTAACTTAGACAGGGTCCTTCCCTCTGAAGTTGAAGTATTGGAGTCCATCTATCTAGATGAACTACAGGTGATTAAAGGAAAT
GGCAGAACTTCACCATGGGAGATCTACATCACTTTGCATCCTGCCACTGCAGAGGACCAGGATTCACAGTATGTCTGCTTCACTCTGGTGCTTCAGGTCCCAGCAGAGTATCCCCATGAGGTGCCACAGATCTCTATCCGAAATCCCCGA
GGACTTTCAGATGAACAGATCCACACGATCTTACAGGTGCTGGGCCACGTGGCCAAGGCTGGGCTGGGCACTGCCATGCTGTATGAACTCATTGAGAAAGGGAAGGAAATTCTCACAGATAACAACATCCCTCATGGCCAGTGTGTCATC
TGCCTCTATGGTTTCCAGGAGAAGGAGGCCTTTACCAAAACACCCTGTTACCACTACTTCCACTGCCACTGCCTTGCTCGGTACATCCAGCACATGGAGCAAGAGCTGAAGGCACAAGGACAGGAGCAGGAACAGGAACGGCAGCATGCT
ACAACCAAACAGAAGGCAGTCGGTGTGCAGTGTCCAGTGTGCAGAGAGCCCCTCGTGTATGATCTTGCCTCACTGAAAGCAGCCCCTGAACCCCAACAGCCCATGGAGCTGTACCAGCCCAGTGCAGAGAGCTTGCGCCAGCAAGAAGAA
CGCAAGCGGCTCTACCAGAGGCAGCAGGAGCGGGGGGGAATCATTGACCTTGAGGCTGAGCGAAACCGATACTTCATCAGCCTTCAGCAGCCTCCTGCCCCTGCGGAACCTGAGTCAGCTGTAGATGTCTCCAAAGGATCCCAACCACCC
AGCACCCTTGCAGCAGAACTATCCACCTCACCAGCCGTCCAATCCACTTTGCCACCTCCTCTGCCTGTGGCGACCCAGCACATATGTGAGAAGATTCCAGGGACCAGGTCAAATCAGCAAAGGTTGGGCGAAACCCAGAAAGCTATGCTA
GATCCCCCCAAGCCCAGTCGAGGTCCCTGGCGACAGCCCGAACGGAGGCACCCAAAGGGAGGGGAGTGCCACGCCCCTAAAGGTACCCGTGACACCCAGGAACTGCCACCTCCTGAGGGGCCCCTCAAGGAGCCCATGGACCTAAAGCCA
GAACCCCATAGCCAAGGAGTTGAAGGTCCTCCACAAGAGAAGGGGCCTGGCAGCTGGCAGGGGCCCCCACCCCGCAGGACTCGGGACTGTGTTCGCTGGGAGCGCTCTAAAGGCCGGACACCCGGTTCTTCCTACCCTCGCCTGCCTCGG
GGCCAGGGAGCATACCGGCCTGGTACTCGGAGGGAGTCCCTGGGCCTGGAATCTAAGGATGGTTCCTAGCAGGACTTGGTGGGGGGAACAGGGAATTGGGGATGGGAGGGAGGCAATAAAGATATTTGGCCTTCTTTGGCTTTCTTTGCT
TAGCAGCGCCTA

N-Truncated Transcript (5UTR-3CDS) Sequences

C-Truncated Transcript (5CDS-3UTR) Sequences

Top

Fusion Protein Sequence for USP37_RNF25

In-frame Fusion Protein Sequences.

N-Truncated Protein (5UTR-3CDS) Sequences

C-Truncated Protein (5CDS-3UTR) Sequences

Top

Personalized Fusion Protein Sequence for USP37_RNF25

TCGA Kinase/DNA-binding Domain Mutated Fusion Protein Sequences

Num

Gene Group

Domain Loci

Fusion Protein ID

Fusion Gene Name

Partner

Mutated Residue in WT Protein

Seq. Length

Mutated Residue in Fusion Protein

CCLE Kinase/DNA-binding Domain Mutated Fusion Protein Sequences

Num

Gene Group

Domain Loci

Fusion Protein ID

Fusion Gene Name

Partner

Mutated Residue in WT Protein

Seq. Length

Mutated Residue in Fusion Protein

TCGA All Mutated Fusion Protein Sequences

Fusion Protein ID

Sample ID

Mutated Partner

AAchange in WT

Seq. Length

AAchange in Fusion

CCLE All Mutated Fusion Protein Sequences

Fusion Protein ID

Sample ID

Mutated Partner

AAchange in WT

Seq. Length

AAchange in Fusion

Top

Fusion Gene Exprssed Samples for USP37_RNF25

RNA-seq based fusion gene expressed samples.

Source	Study	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB		BRCA	TCGA-AO-A128-01A	USP37	chr2	219394678	-	RNF25	chr2	219533402	-
TCGAfusionPortal		BRCA	TCGA-AO-A128-01A	USP37	chr2	219394679	-	RNF25	chr2	219533402	-
WashU		BRCA	TCGA-AO-A128-01A	USP37	chr2	219394679	-	RNF25	chr2	219533402	-
cBioPortal	BRCA_TCGA_PAN_CAN_ATLAS_2018	BRCA	TCGA-AO-A128-01	USP37	chr2	218529956		RNF25	chr2	218668679

DNA-seq based fusion gene expressed samples.

Source

Study

Disease

Sample

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

SV type

Top

Related Drugs for USP37_RNF25

PubMed Abstract Search With ['A-B' AND 'drug'], ['A::B' AND 'drug']
* For more details on the Studied, Reported, Approved Drugs targeting this fusion gene, Go to FusionPub.

PMID

Fusion Gene Name

Drug

Study Title

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status