|
||||||
|
Fusion gene:PTPN1_P2RX4 (FusionGDB2 ID:HG5770TG5025) |
Fusion Gene Summary for PTPN1_P2RX4 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: PTPN1_P2RX4 | Fusion gene ID: hg5770tg5025 | Hgene | Tgene | Gene symbol | PTPN1 | P2RX4 | Gene ID | 5770 | 5025 |
| Gene name | protein tyrosine phosphatase non-receptor type 1 | purinergic receptor P2X 4 | |
| Synonyms | PTP1B | P2X4|P2X4R | |
| Cytomap | 20q13.13 | 12q24.31 | |
| Type of gene | protein-coding | protein-coding | |
| Description | tyrosine-protein phosphatase non-receptor type 1protein tyrosine phosphatase, placentalprotein-tyrosine phosphatase 1B | P2X purinoceptor 4ATP receptorATP-gated cation channel proteinP2X receptor, subunit 4purinergic receptor P2X, ligand gated ion channel, 4purinergic receptor P2X4purinoceptor P2X4 | |
| Modification date | 20240411 | 20240305 | |
| UniProtAcc | . | . | |
| Ensembl transtripts involved in fusion gene | ENST00000371621, ENST00000541713, | ||
| Fusion gene scores | * DoF score | * DoF score (Degree of Frequency) = # partners X # break points X # disease types 17 X 8 X 11=1496 | * DoF score (Degree of Frequency) = # partners X # break points X # disease types 3 X 8 X 5=120 |
| # samples | 39 | 16 | |
| ** MAII score | ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) log2(39/1496*10)=-1.93956414613803 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) log2(16/120*10)=0.415037499278844 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: PTPN1 [Title/Abstract] AND P2RX4 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint | PTPN1(49127127)-P2RX4(121654936), # samples:1 | ||
| Fusion gene breakpoints across PTPN1 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
 |
| Fusion gene breakpoints across P2RX4 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
 |
Top |
Fusion Gene Breakpoints for PTPN1_P2RX4 |
| RNA-seq based exon junction arranged fusion gene breakpoints from 8 resources (TCGA, CCLE, cBioPortal, GenBank, ChimerDB, ChimerKB, ChildHoodFusions, and GTEx). For the expressed sample information, go to Fusion Gene Sample section. |
| Hgene | Hchr | Hbp | Tgene | Tchr | Tbp |
| PTPN1 | chr20 | 49127127 | P2RX4 | chr12 | 121654937 |
| PTPN1 | chr20 | 49127127 | P2RX4 | chr12 | 49127127 |
| PTPN1 | chr20 | 50510590 | P2RX4 | chr12 | 121217134 |
| DNA-seq based exon junction arranged fusion gene breakpoints from dbVar. For the expressed sample information, go to Fusion Gene Sample section. |
| Hgene | Hchr | Hbp | Tgene | Tchr | Tbp | SV type |
Top |
Tumorigenic MoA (Mechanism of Action) Scenarios of Fusion Genes for PTPN1_P2RX4 |
| To generate these tumorigenic scenario annotations, we implemented a deduction-first, retrieval-later computational framework. The pipeline first applies rule-guided reasoning across ten core mechanistic categories (M1–M10) derived from fusion gene biology to infer candidate mechanisms, tumorigenic scenarios, targeting points, and targeting backgrounds. To ensure empirical accountability, a governed Python workflow retrieves literature candidates via NCBI E-utilities and Europe PMC using tiered searches. Using JSON Schema-constrained LLM evidence judges (GPT-5.6 Luna and Terra), retrieved articles are evaluated for specificity and confidence without de novo PMID generation. This produces two distinct versions: a strict version restricted to high- or medium-confidence fusion-specific evidence, and an extended version incorporating broader gene-, pathway-, and contextual evidence. |
| Constitutively Active Kinases, Catalytic Domain Dysregulation, & Transmembrane Ligand Fusions | Aberrant Chimeric Transcription Factor / Fusion Transcription Factor Activity | Epigenetic Reprogramming / Histone Modifier Dysregulation | Chromatin Remodeling Dysregulation | Condensate-Driven Transcriptional Rewiring / LLP | Promoter / Enhancer Hijacking | Dominant-Negative Antagonism | Cell Cycle / Checkpoint Bypass / RNA Processing Dysregulation | Subcellular Mislocalization / Spatial Dysregulation | Nuclear Body / Sub-organellar Architecture Disruption & Differentiation Blockade |  |  |  |  |  |  |  |  |  |  |
* Strict version: Restricted to high- or medium-confidence fusion-specific evidence.
| Fusion Gene Name | Mechanism Category | Mechanism PubMed | Tumorigenic Scenarios | Tumorigenic Scenario PubMed | Targeting Points | Targeting PubMed | Mechanism Background | Mechanism Background PubMed |
| PTPN1-P2RX4 | Constitutively Active Kinases, Catalytic Domain Dysregulation, & Transmembrane Ligand Fusions M1 | Disruption of PTPN1 phosphatase pairs with P2RX4 purinergic receptor ion channel expression, uncoupling RTK dephosphorylation from extracellular ATP-gated calcium signaling. | Purinergic receptor antagonists; PTP1B inhibitors | Carcinomas and solid tumors |
* Extended version: Includes all strict-level fusion evidence plus broader gene-, pathway-, and low-confidence contextual evidence.
| Fusion Gene Name | Mechanism Category | Mechanism PubMed | Tumorigenic Scenarios | Tumorigenic Scenario PubMed | Targeting Points | Targeting PubMed | Mechanism Background | Mechanism Background PubMed |
| PTPN1-P2RX4 | Constitutively Active Kinases, Catalytic Domain Dysregulation, & Transmembrane Ligand Fusions | Disruption of PTPN1 phosphatase pairs with P2RX4 purinergic receptor ion channel expression, uncoupling RTK dephosphorylation from extracellular ATP-gated calcium signaling. | Evidence level: Limited indirect gene evidence; Confidence: Low; PMID: 36385525; Title: Colon tumour cell death causes mTOR dependence by paracrine P2X4 stimulation.; PMID: 36807142; Title: Cationic amphiphilic antihistamines inhibit STAT3 via Ca2+-dependent lysosomal H+ efflux. | Purinergic receptor antagonists; PTP1B inhibitors | Evidence level: Limited indirect gene evidence; Confidence: Low; PMID: 36385525; Title: Colon tumour cell death causes mTOR dependence by paracrine P2X4 stimulation. | Carcinomas and solid tumors | Evidence level: Limited indirect gene evidence; Confidence: Low; PMID: 36385525; Title: Colon tumour cell death causes mTOR dependence by paracrine P2X4 stimulation.; PMID: 36807142; Title: Cationic amphiphilic antihistamines inhibit STAT3 via Ca2+-dependent lysosomal H+ efflux. |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| . | . |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | PTPN1 | GO:0030100 | regulation of endocytosis | 21135139 |
| Hgene | PTPN1 | GO:0030968 | endoplasmic reticulum unfolded protein response | 22169477 |
| Hgene | PTPN1 | GO:0035335 | peptidyl-tyrosine dephosphorylation | 21135139 |
| Hgene | PTPN1 | GO:0061098 | positive regulation of protein tyrosine kinase activity | 21216966 |
| Hgene | PTPN1 | GO:1903898 | negative regulation of PERK-mediated unfolded protein response | 21216966 |
| Tgene | P2RX4 | GO:0007165 | signal transduction | 9016352 |
| Tgene | P2RX4 | GO:0010524 | positive regulation of calcium ion transport into cytosol | 10969036 |
| Tgene | P2RX4 | GO:0033198 | response to ATP | 9016352 |
| Tgene | P2RX4 | GO:0034220 | monoatomic ion transmembrane transport | 10515189 |
| Tgene | P2RX4 | GO:0034405 | response to fluid shear stress | 10969036 |
| Tgene | P2RX4 | GO:0050850 | positive regulation of calcium-mediated signaling | 10969036 |
| Tgene | P2RX4 | GO:0051899 | membrane depolarization | 9016352 |
| Tgene | P2RX4 | GO:0070588 | calcium ion transmembrane transport | 9016352 |
| Tgene | P2RX4 | GO:0071318 | cellular response to ATP | 10515189 |
| Tgene | P2RX4 | GO:0097190 | apoptotic signaling pathway | 17264311 |
Top |
Fusion Genomic Features for PTPN1_P2RX4 |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence) of In-frame fusion genes. FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| PTPN1 | chr20 | 49127127 | + | P2RX4 | chr12 | 121654936 | + | 1.75e-08 | 1.00e+00 |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence) of 5UTR-3CSD fusion genes (N-truncated cases). |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| PTPN1 | chr20 | 49127127 | + | P2RX4 | chr12 | 121654936 | + | 1.75e-08 | 1.00e+00 |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence) of 5CDS-3UTR fusion genes (C-truncated cases). |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| Distribution of six genomic regulatory feature tracks across a ±5 kb window centered on the fusion breakpoints. We input the breakpoint sequences into AlphaGenome and obtained predicted genome tracks at single-base-pair resolution for each modality by running a single forward pass over the reference sequence. Specifically, for each breakpoint, AlphaGenome processed and returned predicted track data across diverse modalities, which were then averaged across all tracks within each output type and visualized across the ±5 kb window. The left panel shows the 5'-gene breakpoint ±5 kb area, and the right panel shows the 3'-gene breakpoint area, with tracks grouped by category: chromatin accessibility (DNase-seq, ATAC-seq), active transcription (RNA-seq, CAGE), and chromatin binding (ChIP-Histone, ChIP-TF). |
 |
Top |
Fusion Gene ORF Annotations for PTPN1_P2RX4 |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-3UTR | ENST00000371621 | ENST00000540930 | PTPN1 | chr20 | 49127127 | + | P2RX4 | chr12 | 121654936 | + |
| 5CDS-3UTR | ENST00000371621 | ENST00000541532 | PTPN1 | chr20 | 49127127 | + | P2RX4 | chr12 | 121654936 | + |
| 5UTR-3CDS | ENST00000541713 | ENST00000337233 | PTPN1 | chr20 | 49127127 | + | P2RX4 | chr12 | 121654936 | + |
| 5UTR-3CDS | ENST00000541713 | ENST00000359949 | PTPN1 | chr20 | 49127127 | + | P2RX4 | chr12 | 121654936 | + |
| 5UTR-3UTR | ENST00000541713 | ENST00000540930 | PTPN1 | chr20 | 49127127 | + | P2RX4 | chr12 | 121654936 | + |
| 5UTR-3UTR | ENST00000541713 | ENST00000541532 | PTPN1 | chr20 | 49127127 | + | P2RX4 | chr12 | 121654936 | + |
| Frame-shift | ENST00000371621 | ENST00000337233 | PTPN1 | chr20 | 49127127 | + | P2RX4 | chr12 | 121654936 | + |
| Frame-shift | ENST00000371621 | ENST00000359949 | PTPN1 | chr20 | 49127127 | + | P2RX4 | chr12 | 121654936 | + |
| ORFfinder Result Based On The Fusion Transcript Sequences of the In-frame Fusion Genes. |
| Henst | Tenst | Hgene | Hchr | Hbp | Tgene | Tchr | Tbp | Seq length (transcript) | Seq length (peptide) |
| ORFfinder Result Based On The Fusion Transcript Sequences of the 5UTR-3CDS Fusion Genes for N-Truncated Protein Search. |
| Henst | Tenst | Hgene | Hchr | Hbp | Tgene | Tchr | Tbp | Seq length (transcript) | Seq length (peptide) |
| ENST00000541713 | ENST00000337233 | PTPN1 | chr20 | 49127127 | P2RX4 | chr12 | 121654936 | 0 | 103 |
| ENST00000541713 | ENST00000359949 | PTPN1 | chr20 | 49127127 | P2RX4 | chr12 | 121654936 | 0 | 141 |
| ORFfinder Result Based On The Fusion Transcript Sequences of the 5CDS-3UTR Fusion Genes for C-Truncated Protein Search. |
| Henst | Tenst | Hgene | Hchr | Hbp | Tgene | Tchr | Tbp | Seq length (transcript) | Seq length (peptide) |
| DeepORF Prediction of The Coding Potential Based on The Fusion Transcript Sequence of In-frame Fusion Genes. DeepORF is a Coding Potential Classifier Based on Convolutional Neural Network by Comparing the Real Ribo-seq Data. If the No-coding Score < 0.5 and Coding Score > 0.5, Then The In-frame Fusion Transcript is Predicted as Being Likely Translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Tgene | Tchr | Tbp | No-coding score | Coding score |
| DeepORF Prediction of The Coding Potential Based on The Fusion Transcript Sequence of 5UTR-3CDS Fusion Genes (Potential N-Truncated Proteins). |
| Henst | Tenst | Hgene | Hchr | Hbp | Tgene | Tchr | Tbp | No-coding score | Coding score |
| ENST00000541713 | ENST00000337233 | PTPN1 | chr20 | 49127127 | P2RX4 | chr12 | 121654936 | 0.00e+00 | 2.11e-03 |
| ENST00000541713 | ENST00000359949 | PTPN1 | chr20 | 49127127 | P2RX4 | chr12 | 121654936 | 0.00e+00 | 2.02e-03 |
| DeepORF Prediction of The Coding Potential Based on The Fusion Transcript Sequence of 5CDS-3UTR Fusion Genes (Potential C-Truncated Proteins). |
| Henst | Tenst | Hgene | Hchr | Hbp | Tgene | Tchr | Tbp | No-coding score | Coding score |
| ENST00000371621 | ENST00000540930 | PTPN1 | chr20 | 49127127 | P2RX4 | chr12 | 121654936 | 0.00e+00 | 3.05e-02 |
| ENST00000371621 | ENST00000541532 | PTPN1 | chr20 | 49127127 | P2RX4 | chr12 | 121654936 | 0.00e+00 | 1.51e-02 |
Top |
Fusion Protein Retained/Non-Retained Functional Features for PTPN1_P2RX4 |
| Protein Level Annotation from FGviewer * Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at download page. Minus value of BPloci means that the break pointn is located before the CDS. |
 |
| - In-frame and retained protein feature among the 13 regional features (visualization across fusion protein length). |
| No matching images found for ${hg}_${tg}. |
| - In-frame and retained protein feature among the 13 regional features (texts). |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - Retained PPIs in in-frame fusion. |
| Partner | Hgene | Hbp | Tgene | Tbp | ENST | UniProt | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Hgene | Hbp | Tgene | Tbp | ENST | UniProt | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
Fusion Transcript Sequence for PTPN1_P2RX4 |
| In-frame Fusion Transcript Sequences. |
| N-Truncated Transcript (5UTR-3CDS) Sequences |
>PTPN1_P2RX4_ENST00000541713_ENST00000337233_49127127_121654936 length=1590nt Breakpoint=0nt GTGGGTGTTTGTGTGGGAAAAGGGCTACCAGGAAACTGACTCCGTGGTCAGCTCCGTTACGACCAAGGTCAAGGGCGTGGCTGTGACCAACACTTCTAAACTTGGATTCCGGATCTGGGATGTGGCGGATTATGTGATACCAGCTCAGGA GGAAAACTCCCTCTTCGTCATGACCAACGTGATCCTCACCATGAACCAGACACAGGGCCTGTGCCCCGAGATTCCAGATGCGACCACTGTGTGTAAATCAGATGCCAGCTGTACTGCCGGCTCTGCCGGCACCCACAGCAACGGAGTCTC AACAGGCAGGTGCGTAGCTTTCAACGGGTCTGTCAAGACGTGTGAGGTGGCGGCCTGGTGCCCGGTGGAGGATGACACACACGTGCCACAACCTGCTTTTTTAAAGGCTGCAGAAAACTTCACTCTTTTGGTTAAGAACAACATCTGGTA TCCCAAATTTAATTTCAGCAAGAGGAATATCCTTCCCAACATCACCACTACTTACCTCAAGTCGTGCATTTATGATGCTAAAACAGATCCCTTCTGCCCCATATTCCGTCTTGGCAAAATAGTGGAGAACGCAGGACACAGTTTCCAGGA CATGGCCGTGGAGGGAGGCATCATGGGCATCCAGGTCAACTGGGACTGCAACCTGGACAGAGCCGCCTCCCTCTGCTTGCCCAGGTACTCCTTCCGCCGCCTCGATACACGGGACGTTGAGCACAACGTATCTCCTGGCTACAATTTCAG GTTTGCCAAGTACTACAGAGACCTGGCTGGCAACGAGCAGCGCACGCTCATCAAGGCCTATGGCATCCGCTTCGACATCATTGTGTTTGGGAAGGCAGGGAAATTTGACATCATCCCCACTATGATCAACATCGGCTCTGGCCTGGCACT GCTAGGCATGGCGACCGTGCTGTGTGACATCATAGTCCTCTACTGCATGAAGAAAAGACTCTACTATCGGGAGAAGAAATATAAATATGTGGAAGATTACGAGCAGGGTCTTGCTAGTGAGCTGGACCAGTGAGGCCTACCCCACACCTG GGCTCTCCACAGCCCCATCAAAGAACAGAGAGGAGGAGGAGGGAGAAATGGCCACCACATCACCCCAGAGAAATTTCTGGAATCTGATTGAGTCTCCACTCCACAAGCACTCAGGGTTCCCCAGCAGCTCCTGTGTGTTGTGTGCAGGAT CTGTTTGCCCACTCGGCCCAGGAGGTCAGCAGTCTGTTCTTGGCTGGGTCAACTCTGCTTTTCCCGCAACCTGGGGTTGTCGGGGGAGCGCTGGCCCGACGCAGTGGCACTGCTGTGGCTTTCAGGGCTGGAGCTGGCTTTGCTCAGAAG CCTCCTGTCTCCAGCTCTCTCCAGGACAGGCCCAGTCCTCTGAGGCACGGCGGCTCTGTTCAAGCACTTTATGCGGCAGGGGAGGCCGCCTGGCTGCAGTCACTAGACTTGTAGCAGGCCTGGGCTGCAGGCTTCCCCCCGACCATTCCC TGCAGCCATGCGGCAGAGCTGGCATTTCTCCTCAGAGAAGCGCTGTGCTAAGGTGATCGAGGACCAGACATTAAAGCGTGATTTTCTTAA >PTPN1_P2RX4_ENST00000541713_ENST00000359949_49127127_121654936 length=1554nt Breakpoint=0nt GTGGGTGTTTGTGTGGGAAAAGGGCTACCAGGAAACTGACTCCGTGGTCAGCTCCGTTACGACCAAGGTCAAGGGCGTGGCTGTGACCAACACTTCTAAACTTGGATTCCGGATCTGGGATGTGGCGGATTATGTGATACCAGCTCAGGA GGAAAACTCCCTCTTCGTCATGACCAACGTGATCCTCACCATGAACCAGACACAGGGCCTGTGCCCCGAGATTCCAGATGCGACCACTGTGTGTAAATCAGATGCCAGCTGTACTGCCGGCTCTGCCGGCACCCACAGCAACGGAGTCTC AACAGGCAGGTGCGTAGCTTTCAACGGGTCTGTCAAGACGTGTGAGGTGGCGGCCTGGTGCCCGGTGGAGGATGACACACACGTGCCACAACCTGCTTTTTTAAAGGCTGCAGAAAACTTCACTCTTTTGGTTAAGAACAACATCTGGTA TCCCAAATTTAATTTCAGCAAGAGGAATATCCTTCCCAACATCACCACTACTTACCTCAAGTCGTGCATTTATGATGCTAAAACAGATCCCTTCTGCCCCATATTCCGTCTTGGCAAAATAGTGGAGAACGCAGGACACAGTTTCCAGGA CATGGCCGTGGAGGGAGGCATCATGGGCATCCAGGTCAACTGGGACTGCAACCTGGACAGAGCCGCCTCCCTCTGCTTGCCCAGGTACTCCTTCCGCCGCCTCGATACACGGGACGTTGAGCACAACGTATCTCCTGGCTACAATTTCAG GTTTGCCAAGTACTACAGAGACCTGGCTGGCAACGAGCAGCGCACGCTCATCAAGGCCTATGGCATCCGCTTCGACATCATTGTGTTTGGGAAGGCAGGGAAATTTGACATCATCCCCACTATGATCAACATCGGCTCTGGCCTGGCACT GCTAGGCATGGCGACCGTGCTGTGTGACATCATAGTCCTCTACTGCATGAAGAAAAGACTCTACTATCGGGAGAAGAAATATAAATATGTGGAAGATTACGAGCAGGGTCTTGCTAGTGAGCTGGACCAGTGAGGCCTACCCCACACCTG GGCTCTCCACAGCCCCATCAAAGAACAGAGAGGAGGAGGAGGGAGAAATGGCCACCACATCACCCCAGAGAAATTTCTGGAATCTGATTGAGTCTCCACTCCACAAGCACTCAGGGTTCCCCAGCAGCTCCTGTGTGTTGTGTGCAGGAT CTGTTTGCCCACTCGGCCCAGGAGGTCAGCAGTCTGTTCTTGGCTGGGTCAACTCTGCTTTTCCCGCAACCTGGGGTTGTCGGGGGAGCGCTGGCCCGACGCAGTGGCACTGCTGTGGCTTTCAGGGCTGGAGCTGGCTTTGCTCAGAAG CCTCCTGTCTCCAGCTCTCTCCAGGACAGGCCCAGTCCTCTGAGGCACGGCGGCTCTGTTCAAGCACTTTATGCGGCAGGGGAGGCCGCCTGGCTGCAGTCACTAGACTTGTAGCAGGCCTGGGCTGCAGGCTTCCCCCCGACCATTCCC TGCAGCCATGCGGCAGAGCTGGCATTTCTCCTCAGAGAAGCGCTGTGCTAAGGT |
| C-Truncated Transcript (5CDS-3UTR) Sequences |
>PTPN1_P2RX4_ENST00000371621_ENST00000540930_49127127_121654936 length=237nt Breakpoint=237nt GTGATGCGTAGTTCCGGCTGCCGGTTGACATGAAGAAGCAGCAGCGGCTAGGGCGGCGGTAGCTGCAGGGGTCGGGGATTGCAGCGGGCCTCGGGGCTAAGAGCGCGACGCGGCCTAGAGCGGCAGACGGCGCAGTGGGCCGAGAAGGAG GCGCAGCAGCCGCCCTGGCCCGTCATGGAGATGGAAAAGGAGTTCGAGCAGATCGACAAGTCCGGGAGCTGGGCGGCCATTTACCAG >PTPN1_P2RX4_ENST00000371621_ENST00000541532_49127127_121654936 length=1053nt Breakpoint=237nt GTGATGCGTAGTTCCGGCTGCCGGTTGACATGAAGAAGCAGCAGCGGCTAGGGCGGCGGTAGCTGCAGGGGTCGGGGATTGCAGCGGGCCTCGGGGCTAAGAGCGCGACGCGGCCTAGAGCGGCAGACGGCGCAGTGGGCCGAGAAGGAG GCGCAGCAGCCGCCCTGGCCCGTCATGGAGATGGAAAAGGAGTTCGAGCAGATCGACAAGTCCGGGAGCTGGGCGGCCATTTACCAGGTGGGTGTTTGTGTGGGAAAAGGGCTACCAGGAAACTGACTCCGTGGTCAGCTCCGTTACGAC CAAGGTCAAGGGCGTGGCTGTGACCAACACTTCTAAACTTGGATTCCGGATCTGGGATGTGGCGGATTATGTGATACCAGCTCAGGAGGAAAACTCCCTCTTCGTCATGACCAACGTGATCCTCACCATGAACCAGACACAGGGCCTGTG CCCCGAGATTCCAGATGCGACCACTGTGTGTAAATCAGATGCCAGCTGTACTGCCGGCTCTGCCGGCACCCACAGCAACGACCTGCTTTTTTAAAGGCTGCAGAAAACTTCACTCTTTTGGTTAAGAACAACATCTGGTATCCCAAATTT AATTTCAGCAAGAGGAATATCCTTCCCAACATCACCACTACTTACCTCAAGTCGTGCATTTATGATGCTAAAACAGATCCCTTCTGCCCCATATTCCGTCTTGGCAAAATAGTGGAGAACGCAGGACACAGTTTCCAGGACATGGCCGTG GAGGGAGGCATCATGGGCATCCAGGTCAACTGGGACTGCAACCTGGACAGAGCCGCCTCCCTCTGCTTGCCCAGGTACTCCTTCCGCCGCCTCGATACACGGGACGTTGAGCACAACGTATCTCCTGGCTACAATTTCAGGTTTGCCAAG TACTACAGAGACCTGGCTGGCAACGAGCAGCGCACGCTCATCAAGGCCTATGGCATCCGCTTCGACATCATTGTGTTTGGGAAGGCAGGGAAATTTGACATCATCCCCACTATGATCAACATCGGCTCTGGCCTGGCACTGCTAGGCATG GTG |
Top |
Fusion Protein Sequence for PTPN1_P2RX4 |
| In-frame Fusion Protein Sequences. |
| N-Truncated Protein (5UTR-3CDS) Sequences |
>PTPN1_P2RX4_ENST00000541713_ENST00000337233_49127127_121654936 length=103nt MWSSHQERWKVTLCTHCSLGVFSLYCCLFYILKIFKKMSRWGLTMLSRLISNSWAQVIHPPWPSKVVGLWAGASVPRLLPFSNFLPASCETTGFGEAVGTHVW >PTPN1_P2RX4_ENST00000541713_ENST00000359949_49127127_121654936 length=141nt MLLRLEEFCSLADLIRSDTSQILEENIPVLKAKLTEMRGIYAKVDRLEAFVKMVGHHVAFLEADVLQAERDHGAFPQALRRWLGSAGLPSFRNVECSGTIPARCNLRLPGSSDSPASASQVAGITEVTCTGARDVRAAHTV |
| C-Truncated Protein (5CDS-3UTR) Sequences |
Top |
Personalized Fusion Protein Sequence for PTPN1_P2RX4 |
| TCGA Kinase/DNA-binding Domain Mutated Fusion Protein Sequences |
| Num | Gene Group | Domain Loci | Fusion Protein ID | Fusion Gene Name | Partner | Mutated Residue in WT Protein | Seq. Length | Mutated Residue in Fusion Protein |
| CCLE Kinase/DNA-binding Domain Mutated Fusion Protein Sequences |
| Num | Gene Group | Domain Loci | Fusion Protein ID | Fusion Gene Name | Partner | Mutated Residue in WT Protein | Seq. Length | Mutated Residue in Fusion Protein |
| TCGA All Mutated Fusion Protein Sequences |
| Fusion Protein ID | Sample ID | Mutated Partner | AAchange in WT | Seq. Length | AAchange in Fusion |
| CCLE All Mutated Fusion Protein Sequences |
| Fusion Protein ID | Sample ID | Mutated Partner | AAchange in WT | Seq. Length | AAchange in Fusion |
Top |
Fusion Gene Exprssed Samples for PTPN1_P2RX4 |
| RNA-seq based fusion gene expressed samples. |
| Source | Study | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB | HNSC | TCGA-CN-5364-01A | PTPN1 | chr20 | 49127127 | - | P2RX4 | chr12 | 0 | + | |
| ChimerDB | HNSC | TCGA-CN-5364-01A | PTPN1 | chr20 | 49127127 | + | P2RX4 | chr12 | 121654937 | + | |
| ChimerDB | HNSC | TCGA-CN-5364-01A | PTPN1 | chr20 | 49127127 | + | P2RX4 | chr12 | 49127127 | + | |
| ChimerDB | HNSC | TCGA-CN-5364 | PTPN1 | chr20 | 49127127 | + | P2RX4 | chr12 | 49127127 | + | |
| TCGAfusionPortal | HNSC | TCGA-CN-5364-01A | PTPN1 | chr20 | 49127127 | + | P2RX4 | chr12 | 121654937 | + | |
| WashU | HNSC | TCGA-CN-5364-01A | PTPN1 | chr20 | 49127127 | + | P2RX4 | chr12 | 121654937 | + | |
| cBioPortal | HNSC_TCGA_PAN_CAN_ATLAS_2018 | HNSC | TCGA-CN-5364-01 | PTPN1 | chr20 | 50510590 | P2RX4 | chr12 | 121217134 |
| DNA-seq based fusion gene expressed samples. |
| Source | Study | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | SV type |
Top |
Related Drugs for PTPN1_P2RX4 |
| PubMed Abstract Search With ['A-B' AND 'drug'], ['A::B' AND 'drug'] * For more details on the Studied, Reported, Approved Drugs targeting this fusion gene, Go to FusionPub. |
| PMID | Fusion Gene Name | Drug | Study Title |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Copyright 2021-Present -The University of Texas Health Science Center at Houston (UTHealth)
Web File Viewing | Emergency Information |Campus Carry|Site Policies