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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene Breakpoints

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Tumorigenic MoA (Mechanism of Action) Scenarios of Fusion Geness

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Fusion Genomic Features

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Fusion Gene ORF Annotations

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Fusion Protein Retained/Non-Retained Functional Features

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Fusion Transcript Sequences

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Fusion Protein Sequences

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Personalized Fusion Protein Sequences

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Fusion Gene Expressed Samples

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Related Drugs

Fusion gene:RPRD1B_CTNNBL1 (FusionGDB2 ID:HG58490TG56259)

Fusion Gene Summary for RPRD1B_CTNNBL1

check button Fusion gene summary
Fusion gene informationFusion gene name: RPRD1B_CTNNBL1
Fusion gene ID: hg58490tg56259
HgeneTgene
Gene symbol

RPRD1B

CTNNBL1

Gene ID

58490

56259

Gene nameregulation of nuclear pre-mRNA domain containing 1Bcatenin beta like 1
SynonymsC20orf77|CREPT|K-H|Kub5-Hera|NET60|dJ1057B20.2C20orf33|IMD99|NAP|P14L|PP8304|dJ633O20.1
Cytomap

20q11.23

20q11.23

Type of geneprotein-codingprotein-coding
Descriptionregulation of nuclear pre-mRNA domain-containing protein 1BKu70-binding protein 5-Heracell-cycle related and expression-elevated protein in tumorbeta-catenin-like protein 1nuclear associated proteintestis development protein NYD-SP19
Modification date2024040320240407
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000373433, ENST00000471511, 
Fusion gene scores* DoF score* DoF score (Degree of Frequency) = # partners X # break points X # disease types
9 X 4 X 7=252		* DoF score (Degree of Frequency) = # partners X # break points X # disease types
5 X 25 X 10=1250
# samples 1426
** MAII score** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)
log2(14/252*10)=-0.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)
log2(26/1250*10)=-2.265344566521
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: RPRD1B [Title/Abstract] AND CTNNBL1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointRPRD1B(36694658)-CTNNBL1(36393598), # samples:1

check buttonFusion gene breakpoints across RPRD1B (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across CTNNBL1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

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Fusion Gene Breakpoints for RPRD1B_CTNNBL1


check button RNA-seq based exon junction arranged fusion gene breakpoints from 8 resources (TCGA, CCLE, cBioPortal, GenBank, ChimerDB, ChimerKB, ChildHoodFusions, and GTEx). For the expressed sample information, go to Fusion Gene Sample section.
HgeneHchrHbpTgeneTchrTbp
RPRD1Bchr2036694658CTNNBL1chr2036694658
RPRD1Bchr2036694658CTNNBL1chr2036393599
RPRD1Bchr2038066256CTNNBL1chr2037765197


check button DNA-seq based exon junction arranged fusion gene breakpoints from dbVar. For the expressed sample information, go to Fusion Gene Sample section.
HgeneHchrHbpTgeneTchrTbpSV type


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Tumorigenic MoA (Mechanism of Action) Scenarios of Fusion Genes for RPRD1B_CTNNBL1


check button To generate these tumorigenic scenario annotations, we implemented a deduction-first, retrieval-later computational framework. The pipeline first applies rule-guided reasoning across ten core mechanistic categories (M1–M10) derived from fusion gene biology to infer candidate mechanisms, tumorigenic scenarios, targeting points, and targeting backgrounds. To ensure empirical accountability, a governed Python workflow retrieves literature candidates via NCBI E-utilities and Europe PMC using tiered searches. Using JSON Schema-constrained LLM evidence judges (GPT-5.6 Luna and Terra), retrieved articles are evaluated for specificity and confidence without de novo PMID generation. This produces two distinct versions: a strict version restricted to high- or medium-confidence fusion-specific evidence, and an extended version incorporating broader gene-, pathway-, and contextual evidence.
* We have 10 tumorigenic mechanism categories of fusion genes as shown below.
Constitutively Active Kinases, Catalytic Domain Dysregulation, & Transmembrane Ligand FusionsAberrant Chimeric Transcription Factor / Fusion Transcription Factor ActivityEpigenetic Reprogramming / Histone Modifier DysregulationChromatin Remodeling DysregulationCondensate-Driven Transcriptional Rewiring / LLPPromoter / Enhancer HijackingDominant-Negative AntagonismCell Cycle / Checkpoint Bypass / RNA Processing DysregulationSubcellular Mislocalization / Spatial DysregulationNuclear Body / Sub-organellar Architecture Disruption & Differentiation Blockade

* Strict version: Restricted to high- or medium-confidence fusion-specific evidence.
Fusion Gene NameMechanism CategoryMechanism PubMedTumorigenic ScenariosTumorigenic Scenario PubMedTargeting PointsTargeting PubMedMechanism BackgroundMechanism Background PubMed
RPRD1B-CTNNBL1
Epigenetic Reprogramming / Histone Modifier Dysregulation
M3		RPRD1B (Kreisler-interacting protein 1 / protein 33) transcriptional coregulator couples to catenin beta-like 1, coordinating transcription regulation with Wnt signaling and pre-mRNA processing.Wnt pathway blockers; HDAC inhibitorsColorectal and Wnt-driven carcinomas

* Extended version: Includes all strict-level fusion evidence plus broader gene-, pathway-, and low-confidence contextual evidence.
Fusion Gene NameMechanism CategoryMechanism PubMedTumorigenic ScenariosTumorigenic Scenario PubMedTargeting PointsTargeting PubMedMechanism BackgroundMechanism Background PubMed
RPRD1B-CTNNBL1
Epigenetic Reprogramming / Histone Modifier Dysregulation
M3		RPRD1B (Kreisler-interacting protein 1 / protein 33) transcriptional coregulator couples to catenin beta-like 1, coordinating transcription regulation with Wnt signaling and pre-mRNA processing.Evidence level: Indirect gene evidence; Confidence: Medium; PMID: 28501461; Title: Spliceosome-associated factor CTNNBL1 promotes proliferation and invasion in ovarian cancer.Wnt pathway blockers; HDAC inhibitorsColorectal and Wnt-driven carcinomas

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneRPRD1B

GO:0008284

positive regulation of cell population proliferation

22264791

HgeneRPRD1B

GO:0010564

regulation of cell cycle process

22264791

HgeneRPRD1B

GO:0045944

positive regulation of transcription by RNA polymerase II

22264791

TgeneCTNNBL1

GO:0043065

positive regulation of apoptotic process

12659813


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Fusion Genomic Features for RPRD1B_CTNNBL1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence) of In-frame fusion genes. FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
RPRD1Bchr2036694658+CTNNBL1chr2036393598+8.14e-111.00e+00


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence) of 5UTR-3CSD fusion genes (N-truncated cases).
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence) of 5CDS-3UTR fusion genes (C-truncated cases).
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of six genomic regulatory feature tracks across a ±5 kb window centered on the fusion breakpoints. We input the breakpoint sequences into AlphaGenome and obtained predicted genome tracks at single-base-pair resolution for each modality by running a single forward pass over the reference sequence. Specifically, for each breakpoint, AlphaGenome processed and returned predicted track data across diverse modalities, which were then averaged across all tracks within each output type and visualized across the ±5 kb window. The left panel shows the 5'-gene breakpoint ±5 kb area, and the right panel shows the 3'-gene breakpoint area, with tracks grouped by category: chromatin accessibility (DNase-seq, ATAC-seq), active transcription (RNA-seq, CAGE), and chromatin binding (ChIP-Histone, ChIP-TF).
genomic feature

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Fusion Gene ORF Annotations for RPRD1B_CTNNBL1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000373433ENST00000473857RPRD1Bchr20

36694658

+CTNNBL1chr20

36393598

+
In-frameENST00000373433ENST00000361383RPRD1Bchr20

36694658

+CTNNBL1chr20

36393598

+
In-frameENST00000373433ENST00000373473RPRD1Bchr20

36694658

+CTNNBL1chr20

36393598

+
In-frameENST00000373433ENST00000405275RPRD1Bchr20

36694658

+CTNNBL1chr20

36393598

+

check buttonORFfinder Result Based On The Fusion Transcript Sequences of the In-frame Fusion Genes.
HenstTenstHgeneHchrHbpTgeneTchrTbpSeq length
(transcript)		Seq length
(peptide)
ENST00000373433ENST00000361383RPRD1Bchr2036694658CTNNBL1chr20363935981233137
ENST00000373433ENST00000373473RPRD1Bchr2036694658CTNNBL1chr20363935981233760
ENST00000373433ENST00000405275RPRD1Bchr2036694658CTNNBL1chr20363935981233760

check buttonORFfinder Result Based On The Fusion Transcript Sequences of the 5UTR-3CDS Fusion Genes for N-Truncated Protein Search.
HenstTenstHgeneHchrHbpTgeneTchrTbpSeq length
(transcript)		Seq length
(peptide)

check buttonORFfinder Result Based On The Fusion Transcript Sequences of the 5CDS-3UTR Fusion Genes for C-Truncated Protein Search.
HenstTenstHgeneHchrHbpTgeneTchrTbpSeq length
(transcript)		Seq length
(peptide)

check buttonDeepORF Prediction of The Coding Potential Based on The Fusion Transcript Sequence of In-frame Fusion Genes. DeepORF is a Coding Potential Classifier Based on Convolutional Neural Network by Comparing the Real Ribo-seq Data. If the No-coding Score < 0.5 and Coding Score > 0.5, Then The In-frame Fusion Transcript is Predicted as Being Likely Translated.
HenstTenstHgeneHchrHbpTgeneTchrTbpNo-coding scoreCoding score
ENST00000373433ENST00000361383RPRD1Bchr2036694658CTNNBL1chr20363935986.42e-051.00e+00
ENST00000373433ENST00000373473RPRD1Bchr2036694658CTNNBL1chr20363935986.42e-051.00e+00
ENST00000373433ENST00000405275RPRD1Bchr2036694658CTNNBL1chr20363935986.78e-051.00e+00

check buttonDeepORF Prediction of The Coding Potential Based on The Fusion Transcript Sequence of 5UTR-3CDS Fusion Genes (Potential N-Truncated Proteins).
HenstTenstHgeneHchrHbpTgeneTchrTbpNo-coding scoreCoding score

check buttonDeepORF Prediction of The Coding Potential Based on The Fusion Transcript Sequence of 5CDS-3UTR Fusion Genes (Potential C-Truncated Proteins).
HenstTenstHgeneHchrHbpTgeneTchrTbpNo-coding scoreCoding score
ENST00000373433ENST00000473857RPRD1Bchr2036694658CTNNBL1chr20363935980.00e+001.30e-01

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Fusion Protein Retained/Non-Retained Functional Features for RPRD1B_CTNNBL1

check buttonProtein Level Annotation from FGviewer
* Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at download page. Minus value of BPloci means that the break pointn is located before the CDS.
fgviewer annotation
- In-frame and retained protein feature among the 13 regional features (visualization across fusion protein length).
RPRD1B_CTNNBL1_chr20-36694658_chr20-36393598.png
RPRD1B_CTNNBL1_chr20-36694658_chr20-36393598.png

- In-frame and retained protein feature among the 13 regional features (texts).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneRPRD1Bchr20:36694658chr20:36393598ENST00000373433Q9NQG567128_144277.0327.0Compositional biasBasic and acidic residues
HgeneRPRD1Bchr20:36694658chr20:36393598ENST00000373433Q9NQG5672_133277.0327.0DomainCID
HgeneRPRD1Bchr20:36694658chr20:36393598ENST00000373433Q9NQG567127_149277.0327.0RegionDisordered
TgeneCTNNBL1chr20:36694658chr20:36393598ENST00000361383Q8WYA6416476_540188.0564.0Coiled coilOntology_term=ECO:0000269
TgeneCTNNBL1chr20:36694658chr20:36393598ENST00000361383Q8WYA6416229_273188.0564.0RepeatNote=ARM 2
TgeneCTNNBL1chr20:36694658chr20:36393598ENST00000361383Q8WYA6416274_323188.0564.0RepeatNote=ARM 3
TgeneCTNNBL1chr20:36694658chr20:36393598ENST00000361383Q8WYA6416325_363188.0564.0RepeatNote=ARM 4
TgeneCTNNBL1chr20:36694658chr20:36393598ENST00000361383Q8WYA6416364_417188.0564.0RepeatNote=ARM 5

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneCTNNBL1chr20:36694658chr20:36393598ENST00000361383Q8WYA641634_45188.0564.0Compositional biasBasic and acidic residues
TgeneCTNNBL1chr20:36694658chr20:36393598ENST00000361383Q8WYA6416130_140188.0564.0MotifNuclear export signal (NES)
TgeneCTNNBL1chr20:36694658chr20:36393598ENST00000361383Q8WYA64161_49188.0564.0RegionDisordered
TgeneCTNNBL1chr20:36694658chr20:36393598ENST00000361383Q8WYA6416134_176188.0564.0RepeatNote=HEAT 2
TgeneCTNNBL1chr20:36694658chr20:36393598ENST00000361383Q8WYA6416178_228188.0564.0RepeatNote=ARM 1
TgeneCTNNBL1chr20:36694658chr20:36393598ENST00000361383Q8WYA641679_129188.0564.0RepeatNote=HEAT 1


check button - Retained PPIs in in-frame fusion.
PartnerHgeneHbpTgeneTbpENSTUniProtStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerHgeneHbpTgeneTbpENSTUniProtStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Fusion Transcript Sequence for RPRD1B_CTNNBL1

check button In-frame Fusion Transcript Sequences.
>RPRD1B_CTNNBL1_ENST00000373433_ENST00000361383_36694658_36393598 length=2477nt
Breakpoint=1233nt
AGGCTCGAGCGGTCAAAGCTCTTTCCGGGGGCCCGGGGAACTACTCTCCTTGCCTCGCTCTGTCTCCTTCGAAGTGCTCTGCGCGAGGTTCAGAGCGGCCGCCGCCTCCAAAGGGACGGTTTTCTAGAGCTCCGACGCCTCTCGGTGCCC
CTCTGCTCCGGCCCTTGCCCTTTGACCTCGCTCTCGCGGCAGGGTGAGAGGTCGGGTGGCCATCTTGTGGCGGCGGCGCGGGCGGCTGTTACTGCGGAGACCCATCCCCTCCCCCTTCTCGCACCCCTGGCAGTCTGTCAGTCGGTAAAA
AGTCCCGCAGCCTGTCAGGTGAGGCCCCGGCCTCGTGCCGTCGCTCTTCCCGCCGCACTGGGCGGCCCAGGCCGCTCCCTGCCGGGCCTCACTGCCGCCACCATGTCCTCCTTCTCTGAGTCGGCGCTGGAGAAGAAGCTCTCGGAGCTG
AGCAACTCTCAGCAGAGCGTGCAGACCCTGTCCCTTTGGCTCATCCACCACCGCAAGCACGCGGGACCCATCGTCTCCGTGTGGCACCGCGAGCTCCGCAAAGCCAAATCAAATAGAAAGCTTACTTTTCTGTATTTAGCGAATGATGTC
ATCCAAAACAGTAAAAGGAAAGGACCTGAATTCACTAGAGAATTTGAATCTGTCCTTGTGGATGCTTTTTCTCATGTTGCCAGAGAGGCAGATGAAGGCTGTAAAAAACCTTTAGAAAGATTGCTGAACATCTGGCAAGAACGAAGTGTG
TATGGCGGCGAGTTCATACAGCAGCTGAAGCTGTCTATGGAGGACTCCAAGAGCCCTCCCCCCAAAGCAACAGAAGAGAAGAAATCTCTGAAACGAACTTTTCAGCAAATTCAGGAGGAGGAGGATGACGACTACCCTGGCAGCTACTCT
CCTCAGGATCCTTCTGCAGGACCCCTCTTGACTGAGGAACTAATCAAAGCTTTGCAGGATCTGGAAAATGCCGCATCAGGGGATGCTACTGTCCGACAGAAAATTGCTTCTCTGCCCCAGGAAGTGCAAGATGTTTCTCTATTGGAAAAA
ATAACAGACAAAGAGGCAGCTGAACGTCTTTCAAAAACAGTAGATGAAGCATGTCTGTTACTAGCAGAATATAACGGGCGCCTGGCAGCAGAACTGGAGGACCGTCGCCAGCTGGCTCGGATGTTGGTGGAGTATACCCAGAATCAGAAA
GATGTTTTGTCGGAGAAGGAGAAAAAACTAGAGGTGGATGGGCAGGTGGTAGCACTGCTGGTACAGAATCTGGAGCGCCTGGATGAGTCTGTGAAAGAGGAGGCAGATGGCGTCCACAACACTCTGGCTATTGTGGAAAACATGGCTGAG
TTCCGGCCTGAGATGTGTACAGAGGGTGCCCAGCAGGGTCTTCTACAGTGGCTGTTGAAGAGGCTGAAGGCAAAGATGCCTTTTGATGCCAACAAACTGTATTGCAGTGAAGTGCTGGCCATATTGCTCCAGGACAATGATGAAAACAGG
GAATTGCTTGGGGAGCTGGATGGAATCGATGTGCTTCTTCAGCAGTTATCCGTGTTTAAAAGACACAATCCCAGCACGGCTGAGGAGCAGGAGATGATGGAGAATCTGTTTGATTCCCTCTGCTCCTGTCTAATGCTTAGTTCCAATCGT
GAGCGCTTCCTGAAGGGCGAGGGTCTTCAGCTGATGAATCTCATGCTCAGGGAAAAGAAGATCTCCCGGAGCAGTGCCCTGAAAGTGCTGGACCATGCCATGATTGGCCCCGAAGGCACAGACAACTGCCATAAGTTTGTTGACATTCTT
GGCTTACGAACCATCTTTCCCCTCTTTATGAAATCTCCCAGGAAGATCAAGAAAGTGGGAACCACTGAGAAGGAACATGAAGAGCATGTCTGTTCGATCCTGGCTTCCCTCCTGCGGAACCTGAGAGGGCAGCAGCGGACCCGGCTTCTG
AATAAATTCACTGAAAATGACAGTGAGAAGGTTGACAGACTAATGGAGTTGCATTTTAAATATCTGGGTGCAATGCAGGTGGCGGACAAGAAGATTGAAGGGGAAAAACACGACATGGTCCGGCGAGGAGAGATCATCGACAATGACACC
GAGGAGGAGTTCTACCTCCGGCGCCTGGATGCGGGGCTCTTTGTTCTCCAGCACATCTGCTACATCATGGCCGAGATCTGCAATGCCAATGTCCCCCAGATTCGCCAGAGGGTTCACCAGATCCTAAACATGCGAGGAAGCTCCATCAAA
ATTGTCAGGCATATCATCAAGGAGTATGCAGAGAACATCGGGGACGGCCGGAGCCCGGAGTTCCGGGAGAACGAGCAAAAGCGCATCCTGGGCTTGCTGGAGAACTTCTAGAGGCACCTTGGCCCTGCGCATCATGGACTCTCTCAGCTT
CCCTCCCAGGATCAGTTTCTACACAACTCTGTGTGGCTTTTGGACAAATTAAAGCTAGTTTTGGTATCCCCGGGCCA

>RPRD1B_CTNNBL1_ENST00000373433_ENST00000373473_36694658_36393598 length=2477nt
Breakpoint=1233nt
AGGCTCGAGCGGTCAAAGCTCTTTCCGGGGGCCCGGGGAACTACTCTCCTTGCCTCGCTCTGTCTCCTTCGAAGTGCTCTGCGCGAGGTTCAGAGCGGCCGCCGCCTCCAAAGGGACGGTTTTCTAGAGCTCCGACGCCTCTCGGTGCCC
CTCTGCTCCGGCCCTTGCCCTTTGACCTCGCTCTCGCGGCAGGGTGAGAGGTCGGGTGGCCATCTTGTGGCGGCGGCGCGGGCGGCTGTTACTGCGGAGACCCATCCCCTCCCCCTTCTCGCACCCCTGGCAGTCTGTCAGTCGGTAAAA
AGTCCCGCAGCCTGTCAGGTGAGGCCCCGGCCTCGTGCCGTCGCTCTTCCCGCCGCACTGGGCGGCCCAGGCCGCTCCCTGCCGGGCCTCACTGCCGCCACCATGTCCTCCTTCTCTGAGTCGGCGCTGGAGAAGAAGCTCTCGGAGCTG
AGCAACTCTCAGCAGAGCGTGCAGACCCTGTCCCTTTGGCTCATCCACCACCGCAAGCACGCGGGACCCATCGTCTCCGTGTGGCACCGCGAGCTCCGCAAAGCCAAATCAAATAGAAAGCTTACTTTTCTGTATTTAGCGAATGATGTC
ATCCAAAACAGTAAAAGGAAAGGACCTGAATTCACTAGAGAATTTGAATCTGTCCTTGTGGATGCTTTTTCTCATGTTGCCAGAGAGGCAGATGAAGGCTGTAAAAAACCTTTAGAAAGATTGCTGAACATCTGGCAAGAACGAAGTGTG
TATGGCGGCGAGTTCATACAGCAGCTGAAGCTGTCTATGGAGGACTCCAAGAGCCCTCCCCCCAAAGCAACAGAAGAGAAGAAATCTCTGAAACGAACTTTTCAGCAAATTCAGGAGGAGGAGGATGACGACTACCCTGGCAGCTACTCT
CCTCAGGATCCTTCTGCAGGACCCCTCTTGACTGAGGAACTAATCAAAGCTTTGCAGGATCTGGAAAATGCCGCATCAGGGGATGCTACTGTCCGACAGAAAATTGCTTCTCTGCCCCAGGAAGTGCAAGATGTTTCTCTATTGGAAAAA
ATAACAGACAAAGAGGCAGCTGAACGTCTTTCAAAAACAGTAGATGAAGCATGTCTGTTACTAGCAGAATATAACGGGCGCCTGGCAGCAGAACTGGAGGACCGTCGCCAGCTGGCTCGGATGTTGGTGGAGTATACCCAGAATCAGAAA
GATGTTTTGTCGGAGAAGGAGAAAAAACTAGAGGTGGATGGGCAGGTGGTAGCACTGCTGGTACAGAATCTGGAGCGCCTGGATGAGTCTGTGAAAGAGGAGGCAGATGGCGTCCACAACACTCTGGCTATTGTGGAAAACATGGCTGAG
TTCCGGCCTGAGATGTGTACAGAGGGTGCCCAGCAGGGTCTTCTACAGTGGCTGTTGAAGAGGCTGAAGGCAAAGATGCCTTTTGATGCCAACAAACTGTATTGCAGTGAAGTGCTGGCCATATTGCTCCAGGACAATGATGAAAACAGG
GAATTGCTTGGGGAGCTGGATGGAATCGATGTGCTTCTTCAGCAGTTATCCGTGTTTAAAAGACACAATCCCAGCACGGCTGAGGAGCAGGAGATGATGGAGAATCTGTTTGATTCCCTCTGCTCCTGTCTAATGCTTAGTTCCAATCGT
GAGCGCTTCCTGAAGGGCGAGGGTCTTCAGCTGATGAATCTCATGCTCAGGGAAAAGAAGATCTCCCGGAGCAGTGCCCTGAAAGTGCTGGACCATGCCATGATTGGCCCCGAAGGCACAGACAACTGCCATAAGTTTGTTGACATTCTT
GGCTTACGAACCATCTTTCCCCTCTTTATGAAATCTCCCAGGAAGATCAAGAAAGTGGGAACCACTGAGAAGGAACATGAAGAGCATGTCTGTTCGATCCTGGCTTCCCTCCTGCGGAACCTGAGAGGGCAGCAGCGGACCCGGCTTCTG
AATAAATTCACTGAAAATGACAGTGAGAAGGTTGACAGACTAATGGAGTTGCATTTTAAATATCTGGGTGCAATGCAGGTGGCGGACAAGAAGATTGAAGGGGAAAAACACGACATGGTCCGGCGAGGAGAGATCATCGACAATGACACC
GAGGAGGAGTTCTACCTCCGGCGCCTGGATGCGGGGCTCTTTGTTCTCCAGCACATCTGCTACATCATGGCCGAGATCTGCAATGCCAATGTCCCCCAGATTCGCCAGAGGGTTCACCAGATCCTAAACATGCGAGGAAGCTCCATCAAA
ATTGTCAGGCATATCATCAAGGAGTATGCAGAGAACATCGGGGACGGCCGGAGCCCGGAGTTCCGGGAGAACGAGCAAAAGCGCATCCTGGGCTTGCTGGAGAACTTCTAGAGGCACCTTGGCCCTGCGCATCATGGACTCTCTCAGCTT
CCCTCCCAGGATCAGTTTCTACACAACTCTGTGTGGCTTTTGGACAAATTAAAGCTAGTTTTGGTATCCCCGGGCCA

>RPRD1B_CTNNBL1_ENST00000373433_ENST00000405275_36694658_36393598 length=2465nt
Breakpoint=1233nt
AGGCTCGAGCGGTCAAAGCTCTTTCCGGGGGCCCGGGGAACTACTCTCCTTGCCTCGCTCTGTCTCCTTCGAAGTGCTCTGCGCGAGGTTCAGAGCGGCCGCCGCCTCCAAAGGGACGGTTTTCTAGAGCTCCGACGCCTCTCGGTGCCC
CTCTGCTCCGGCCCTTGCCCTTTGACCTCGCTCTCGCGGCAGGGTGAGAGGTCGGGTGGCCATCTTGTGGCGGCGGCGCGGGCGGCTGTTACTGCGGAGACCCATCCCCTCCCCCTTCTCGCACCCCTGGCAGTCTGTCAGTCGGTAAAA
AGTCCCGCAGCCTGTCAGGTGAGGCCCCGGCCTCGTGCCGTCGCTCTTCCCGCCGCACTGGGCGGCCCAGGCCGCTCCCTGCCGGGCCTCACTGCCGCCACCATGTCCTCCTTCTCTGAGTCGGCGCTGGAGAAGAAGCTCTCGGAGCTG
AGCAACTCTCAGCAGAGCGTGCAGACCCTGTCCCTTTGGCTCATCCACCACCGCAAGCACGCGGGACCCATCGTCTCCGTGTGGCACCGCGAGCTCCGCAAAGCCAAATCAAATAGAAAGCTTACTTTTCTGTATTTAGCGAATGATGTC
ATCCAAAACAGTAAAAGGAAAGGACCTGAATTCACTAGAGAATTTGAATCTGTCCTTGTGGATGCTTTTTCTCATGTTGCCAGAGAGGCAGATGAAGGCTGTAAAAAACCTTTAGAAAGATTGCTGAACATCTGGCAAGAACGAAGTGTG
TATGGCGGCGAGTTCATACAGCAGCTGAAGCTGTCTATGGAGGACTCCAAGAGCCCTCCCCCCAAAGCAACAGAAGAGAAGAAATCTCTGAAACGAACTTTTCAGCAAATTCAGGAGGAGGAGGATGACGACTACCCTGGCAGCTACTCT
CCTCAGGATCCTTCTGCAGGACCCCTCTTGACTGAGGAACTAATCAAAGCTTTGCAGGATCTGGAAAATGCCGCATCAGGGGATGCTACTGTCCGACAGAAAATTGCTTCTCTGCCCCAGGAAGTGCAAGATGTTTCTCTATTGGAAAAA
ATAACAGACAAAGAGGCAGCTGAACGTCTTTCAAAAACAGTAGATGAAGCATGTCTGTTACTAGCAGAATATAACGGGCGCCTGGCAGCAGAACTGGAGGACCGTCGCCAGCTGGCTCGGATGTTGGTGGAGTATACCCAGAATCAGAAA
GATGTTTTGTCGGAGAAGGAGAAAAAACTAGAGGTGGATGGGCAGGTGGTAGCACTGCTGGTACAGAATCTGGAGCGCCTGGATGAGTCTGTGAAAGAGGAGGCAGATGGCGTCCACAACACTCTGGCTATTGTGGAAAACATGGCTGAG
TTCCGGCCTGAGATGTGTACAGAGGGTGCCCAGCAGGGTCTTCTACAGTGGCTGTTGAAGAGGCTGAAGGCAAAGATGCCTTTTGATGCCAACAAACTGTATTGCAGTGAAGTGCTGGCCATATTGCTCCAGGACAATGATGAAAACAGG
GAATTGCTTGGGGAGCTGGATGGAATCGATGTGCTTCTTCAGCAGTTATCCGTGTTTAAAAGACACAATCCCAGCACGGCTGAGGAGCAGGAGATGATGGAGAATCTGTTTGATTCCCTCTGCTCCTGTCTAATGCTTAGTTCCAATCGT
GAGCGCTTCCTGAAGGGCGAGGGTCTTCAGCTGATGAATCTCATGCTCAGGGAAAAGAAGATCTCCCGGAGCAGTGCCCTGAAAGTGCTGGACCATGCCATGATTGGCCCCGAAGGCACAGACAACTGCCATAAGTTTGTTGACATTCTT
GGCTTACGAACCATCTTTCCCCTCTTTATGAAATCTCCCAGGAAGATCAAGAAAGTGGGAACCACTGAGAAGGAACATGAAGAGCATGTCTGTTCGATCCTGGCTTCCCTCCTGCGGAACCTGAGAGGGCAGCAGCGGACCCGGCTTCTG
AATAAATTCACTGAAAATGACAGTGAGAAGGTTGACAGACTAATGGAGTTGCATTTTAAATATCTGGGTGCAATGCAGGTGGCGGACAAGAAGATTGAAGGGGAAAAACACGACATGGTCCGGCGAGGAGAGATCATCGACAATGACACC
GAGGAGGAGTTCTACCTCCGGCGCCTGGATGCGGGGCTCTTTGTTCTCCAGCACATCTGCTACATCATGGCCGAGATCTGCAATGCCAATGTCCCCCAGATTCGCCAGAGGGTTCACCAGATCCTAAACATGCGAGGAAGCTCCATCAAA
ATTGTCAGGCATATCATCAAGGAGTATGCAGAGAACATCGGGGACGGCCGGAGCCCGGAGTTCCGGGAGAACGAGCAAAAGCGCATCCTGGGCTTGCTGGAGAACTTCTAGAGGCACCTTGGCCCTGCGCATCATGGACTCTCTCAGCTT
CCCTCCCAGGATCAGTTTCTACACAACTCTGTGTGGCTTTTGGACAAATTAAAGCTAGTTTTGGT


check button N-Truncated Transcript (5UTR-3CDS) Sequences

check button C-Truncated Transcript (5CDS-3UTR) Sequences
>RPRD1B_CTNNBL1_ENST00000373433_ENST00000473857_36694658_36393598 length=1233nt
Breakpoint=1233nt
AGGCTCGAGCGGTCAAAGCTCTTTCCGGGGGCCCGGGGAACTACTCTCCTTGCCTCGCTCTGTCTCCTTCGAAGTGCTCTGCGCGAGGTTCAGAGCGGCCGCCGCCTCCAAAGGGACGGTTTTCTAGAGCTCCGACGCCTCTCGGTGCCC
CTCTGCTCCGGCCCTTGCCCTTTGACCTCGCTCTCGCGGCAGGGTGAGAGGTCGGGTGGCCATCTTGTGGCGGCGGCGCGGGCGGCTGTTACTGCGGAGACCCATCCCCTCCCCCTTCTCGCACCCCTGGCAGTCTGTCAGTCGGTAAAA
AGTCCCGCAGCCTGTCAGGTGAGGCCCCGGCCTCGTGCCGTCGCTCTTCCCGCCGCACTGGGCGGCCCAGGCCGCTCCCTGCCGGGCCTCACTGCCGCCACCATGTCCTCCTTCTCTGAGTCGGCGCTGGAGAAGAAGCTCTCGGAGCTG
AGCAACTCTCAGCAGAGCGTGCAGACCCTGTCCCTTTGGCTCATCCACCACCGCAAGCACGCGGGACCCATCGTCTCCGTGTGGCACCGCGAGCTCCGCAAAGCCAAATCAAATAGAAAGCTTACTTTTCTGTATTTAGCGAATGATGTC
ATCCAAAACAGTAAAAGGAAAGGACCTGAATTCACTAGAGAATTTGAATCTGTCCTTGTGGATGCTTTTTCTCATGTTGCCAGAGAGGCAGATGAAGGCTGTAAAAAACCTTTAGAAAGATTGCTGAACATCTGGCAAGAACGAAGTGTG
TATGGCGGCGAGTTCATACAGCAGCTGAAGCTGTCTATGGAGGACTCCAAGAGCCCTCCCCCCAAAGCAACAGAAGAGAAGAAATCTCTGAAACGAACTTTTCAGCAAATTCAGGAGGAGGAGGATGACGACTACCCTGGCAGCTACTCT
CCTCAGGATCCTTCTGCAGGACCCCTCTTGACTGAGGAACTAATCAAAGCTTTGCAGGATCTGGAAAATGCCGCATCAGGGGATGCTACTGTCCGACAGAAAATTGCTTCTCTGCCCCAGGAAGTGCAAGATGTTTCTCTATTGGAAAAA
ATAACAGACAAAGAGGCAGCTGAACGTCTTTCAAAAACAGTAGATGAAGCATGTCTGTTACTAGCAGAATATAACGGGCGCCTGGCAGCAGAACTGGAGGACCGTCGCCAGCTGGCTCGGATGTTGGTGGAGTATACCCAGAATCAGAAA
GATGTTTTGTCGGAGAAGGAGAAAAAACTAGAG


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Fusion Protein Sequence for RPRD1B_CTNNBL1

check button In-frame Fusion Protein Sequences.
>RPRD1B_CTNNBL1_ENST00000373433_ENST00000361383_36694658_36393598 length=137nt
MEAMSENKMVPSEFSTGPVEKAAKPLPFKDPNFVHSGHGGAVAGKKNRTWKNLKQILASERALPWQLNDPNYFSIDAPPSFKPAKKYSDVSGLLANYTDPQSKLRFSTIEEFSYIRRLPSDVVTGYLALRKATSIVP

>RPRD1B_CTNNBL1_ENST00000373433_ENST00000373473_36694658_36393598 length=760nt
MREVQSGRRLQRDGFLELRRLSVPLCSGPCPLTSLSRQGERSGGHLVAAARAAVTAETHPLPLLAPLAVCQSVKSPAACQVRPRPRAVALPAALGGPGRSLPGLTAATMSSFSESALEKKLSELSNSQQSVQTLSLWLIHHRKHAGPIVS
VWHRELRKAKSNRKLTFLYLANDVIQNSKRKGPEFTREFESVLVDAFSHVAREADEGCKKPLERLLNIWQERSVYGGEFIQQLKLSMEDSKSPPPKATEEKKSLKRTFQQIQEEEDDDYPGSYSPQDPSAGPLLTEELIKALQDLENAAS
GDATVRQKIASLPQEVQDVSLLEKITDKEAAERLSKTVDEACLLLAEYNGRLAAELEDRRQLARMLVEYTQNQKDVLSEKEKKLEVDGQVVALLVQNLERLDESVKEEADGVHNTLAIVENMAEFRPEMCTEGAQQGLLQWLLKRLKAKM
PFDANKLYCSEVLAILLQDNDENRELLGELDGIDVLLQQLSVFKRHNPSTAEEQEMMENLFDSLCSCLMLSSNRERFLKGEGLQLMNLMLREKKISRSSALKVLDHAMIGPEGTDNCHKFVDILGLRTIFPLFMKSPRKIKKVGTTEKEH
EEHVCSILASLLRNLRGQQRTRLLNKFTENDSEKVDRLMELHFKYLGAMQVADKKIEGEKHDMVRRGEIIDNDTEEEFYLRRLDAGLFVLQHICYIMAEICNANVPQIRQRVHQILNMRGSSIKIVRHIIKEYAENIGDGRSPEFRENEQ
KRILGLLENF

>RPRD1B_CTNNBL1_ENST00000373433_ENST00000405275_36694658_36393598 length=760nt
MREVQSGRRLQRDGFLELRRLSVPLCSGPCPLTSLSRQGERSGGHLVAAARAAVTAETHPLPLLAPLAVCQSVKSPAACQVRPRPRAVALPAALGGPGRSLPGLTAATMSSFSESALEKKLSELSNSQQSVQTLSLWLIHHRKHAGPIVS
VWHRELRKAKSNRKLTFLYLANDVIQNSKRKGPEFTREFESVLVDAFSHVAREADEGCKKPLERLLNIWQERSVYGGEFIQQLKLSMEDSKSPPPKATEEKKSLKRTFQQIQEEEDDDYPGSYSPQDPSAGPLLTEELIKALQDLENAAS
GDATVRQKIASLPQEVQDVSLLEKITDKEAAERLSKTVDEACLLLAEYNGRLAAELEDRRQLARMLVEYTQNQKDVLSEKEKKLEVDGQVVALLVQNLERLDESVKEEADGVHNTLAIVENMAEFRPEMCTEGAQQGLLQWLLKRLKAKM
PFDANKLYCSEVLAILLQDNDENRELLGELDGIDVLLQQLSVFKRHNPSTAEEQEMMENLFDSLCSCLMLSSNRERFLKGEGLQLMNLMLREKKISRSSALKVLDHAMIGPEGTDNCHKFVDILGLRTIFPLFMKSPRKIKKVGTTEKEH
EEHVCSILASLLRNLRGQQRTRLLNKFTENDSEKVDRLMELHFKYLGAMQVADKKIEGEKHDMVRRGEIIDNDTEEEFYLRRLDAGLFVLQHICYIMAEICNANVPQIRQRVHQILNMRGSSIKIVRHIIKEYAENIGDGRSPEFRENEQ
KRILGLLENF


check button N-Truncated Protein (5UTR-3CDS) Sequences

check button C-Truncated Protein (5CDS-3UTR) Sequences

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Personalized Fusion Protein Sequence for RPRD1B_CTNNBL1


check button TCGA Kinase/DNA-binding Domain Mutated Fusion Protein Sequences
NumGene GroupDomain LociFusion Protein IDFusion Gene NamePartnerMutated Residue in WT ProteinSeq. LengthMutated Residue in Fusion Protein

check button CCLE Kinase/DNA-binding Domain Mutated Fusion Protein Sequences

NumGene GroupDomain LociFusion Protein IDFusion Gene NamePartnerMutated Residue in WT ProteinSeq. LengthMutated Residue in Fusion Protein

check button TCGA All Mutated Fusion Protein Sequences
>RPRD1B_CTNNBL1_ENST00000373433_ENST00000373473_36694658_36393598_5-gene_p.S128P_760_S236P length=760AA
MREVQSGRRLQRDGFLELRRLSVPLCSGPCPLTSLSRQGERSGGHLVAAARAAVTAETHPLPLLAPLAVCQSVKSPAACQVRPRPRAVALPAALGGPGRSLPGLTAATMSSFSESALEKKLSELSNSQQSVQTLSLWLIHHRKHAGPIVS
VWHRELRKAKSNRKLTFLYLANDVIQNSKRKGPEFTREFESVLVDAFSHVAREADEGCKKPLERLLNIWQERSVYGGEFIQQLKLPMEDSKSPPPKATEEKKSLKRTFQQIQEEEDDDYPGSYSPQDPSAGPLLTEELIKALQDLENAAS
GDATVRQKIASLPQEVQDVSLLEKITDKEAAERLSKTVDEACLLLAEYNGRLAAELEDRRQLARMLVEYTQNQKDVLSEKEKKLEVDGQVVALLVQNLERLDESVKEEADGVHNTLAIVENMAEFRPEMCTEGAQQGLLQWLLKRLKAKM
PFDANKLYCSEVLAILLQDNDENRELLGELDGIDVLLQQLSVFKRHNPSTAEEQEMMENLFDSLCSCLMLSSNRERFLKGEGLQLMNLMLREKKISRSSALKVLDHAMIGPEGTDNCHKFVDILGLRTIFPLFMKSPRKIKKVGTTEKEH
EEHVCSILASLLRNLRGQQRTRLLNKFTENDSEKVDRLMELHFKYLGAMQVADKKIEGEKHDMVRRGEIIDNDTEEEFYLRRLDAGLFVLQHICYIMAEICNANVPQIRQRVHQILNMRGSSIKIVRHIIKEYAENIGDGRSPEFRENEQ
KRILGLLENF

>RPRD1B_CTNNBL1_ENST00000373433_ENST00000373473_36694658_36393598_5-gene_p.G119C_760_G227C length=760AA
MREVQSGRRLQRDGFLELRRLSVPLCSGPCPLTSLSRQGERSGGHLVAAARAAVTAETHPLPLLAPLAVCQSVKSPAACQVRPRPRAVALPAALGGPGRSLPGLTAATMSSFSESALEKKLSELSNSQQSVQTLSLWLIHHRKHAGPIVS
VWHRELRKAKSNRKLTFLYLANDVIQNSKRKGPEFTREFESVLVDAFSHVAREADEGCKKPLERLLNIWQERSVYGCEFIQQLKLSMEDSKSPPPKATEEKKSLKRTFQQIQEEEDDDYPGSYSPQDPSAGPLLTEELIKALQDLENAAS
GDATVRQKIASLPQEVQDVSLLEKITDKEAAERLSKTVDEACLLLAEYNGRLAAELEDRRQLARMLVEYTQNQKDVLSEKEKKLEVDGQVVALLVQNLERLDESVKEEADGVHNTLAIVENMAEFRPEMCTEGAQQGLLQWLLKRLKAKM
PFDANKLYCSEVLAILLQDNDENRELLGELDGIDVLLQQLSVFKRHNPSTAEEQEMMENLFDSLCSCLMLSSNRERFLKGEGLQLMNLMLREKKISRSSALKVLDHAMIGPEGTDNCHKFVDILGLRTIFPLFMKSPRKIKKVGTTEKEH
EEHVCSILASLLRNLRGQQRTRLLNKFTENDSEKVDRLMELHFKYLGAMQVADKKIEGEKHDMVRRGEIIDNDTEEEFYLRRLDAGLFVLQHICYIMAEICNANVPQIRQRVHQILNMRGSSIKIVRHIIKEYAENIGDGRSPEFRENEQ
KRILGLLENF

>RPRD1B_CTNNBL1_ENST00000373433_ENST00000373473_36694658_36393598_5-gene_p.R251H_760_R359H length=760AA
MREVQSGRRLQRDGFLELRRLSVPLCSGPCPLTSLSRQGERSGGHLVAAARAAVTAETHPLPLLAPLAVCQSVKSPAACQVRPRPRAVALPAALGGPGRSLPGLTAATMSSFSESALEKKLSELSNSQQSVQTLSLWLIHHRKHAGPIVS
VWHRELRKAKSNRKLTFLYLANDVIQNSKRKGPEFTREFESVLVDAFSHVAREADEGCKKPLERLLNIWQERSVYGGEFIQQLKLSMEDSKSPPPKATEEKKSLKRTFQQIQEEEDDDYPGSYSPQDPSAGPLLTEELIKALQDLENAAS
GDATVRQKIASLPQEVQDVSLLEKITDKEAAERLSKTVDEACLLLAEYNGRLAAELEDHRQLARMLVEYTQNQKDVLSEKEKKLEVDGQVVALLVQNLERLDESVKEEADGVHNTLAIVENMAEFRPEMCTEGAQQGLLQWLLKRLKAKM
PFDANKLYCSEVLAILLQDNDENRELLGELDGIDVLLQQLSVFKRHNPSTAEEQEMMENLFDSLCSCLMLSSNRERFLKGEGLQLMNLMLREKKISRSSALKVLDHAMIGPEGTDNCHKFVDILGLRTIFPLFMKSPRKIKKVGTTEKEH
EEHVCSILASLLRNLRGQQRTRLLNKFTENDSEKVDRLMELHFKYLGAMQVADKKIEGEKHDMVRRGEIIDNDTEEEFYLRRLDAGLFVLQHICYIMAEICNANVPQIRQRVHQILNMRGSSIKIVRHIIKEYAENIGDGRSPEFRENEQ
KRILGLLENF

>RPRD1B_CTNNBL1_ENST00000373433_ENST00000373473_36694658_36393598_5-gene_p.R243L_760_R351L length=760AA
MREVQSGRRLQRDGFLELRRLSVPLCSGPCPLTSLSRQGERSGGHLVAAARAAVTAETHPLPLLAPLAVCQSVKSPAACQVRPRPRAVALPAALGGPGRSLPGLTAATMSSFSESALEKKLSELSNSQQSVQTLSLWLIHHRKHAGPIVS
VWHRELRKAKSNRKLTFLYLANDVIQNSKRKGPEFTREFESVLVDAFSHVAREADEGCKKPLERLLNIWQERSVYGGEFIQQLKLSMEDSKSPPPKATEEKKSLKRTFQQIQEEEDDDYPGSYSPQDPSAGPLLTEELIKALQDLENAAS
GDATVRQKIASLPQEVQDVSLLEKITDKEAAERLSKTVDEACLLLAEYNGLLAAELEDRRQLARMLVEYTQNQKDVLSEKEKKLEVDGQVVALLVQNLERLDESVKEEADGVHNTLAIVENMAEFRPEMCTEGAQQGLLQWLLKRLKAKM
PFDANKLYCSEVLAILLQDNDENRELLGELDGIDVLLQQLSVFKRHNPSTAEEQEMMENLFDSLCSCLMLSSNRERFLKGEGLQLMNLMLREKKISRSSALKVLDHAMIGPEGTDNCHKFVDILGLRTIFPLFMKSPRKIKKVGTTEKEH
EEHVCSILASLLRNLRGQQRTRLLNKFTENDSEKVDRLMELHFKYLGAMQVADKKIEGEKHDMVRRGEIIDNDTEEEFYLRRLDAGLFVLQHICYIMAEICNANVPQIRQRVHQILNMRGSSIKIVRHIIKEYAENIGDGRSPEFRENEQ
KRILGLLENF

>RPRD1B_CTNNBL1_ENST00000373433_ENST00000373473_36694658_36393598_5-gene_p.H32Y_760_H140Y length=760AA
MREVQSGRRLQRDGFLELRRLSVPLCSGPCPLTSLSRQGERSGGHLVAAARAAVTAETHPLPLLAPLAVCQSVKSPAACQVRPRPRAVALPAALGGPGRSLPGLTAATMSSFSESALEKKLSELSNSQQSVQTLSLWLIYHRKHAGPIVS
VWHRELRKAKSNRKLTFLYLANDVIQNSKRKGPEFTREFESVLVDAFSHVAREADEGCKKPLERLLNIWQERSVYGGEFIQQLKLSMEDSKSPPPKATEEKKSLKRTFQQIQEEEDDDYPGSYSPQDPSAGPLLTEELIKALQDLENAAS
GDATVRQKIASLPQEVQDVSLLEKITDKEAAERLSKTVDEACLLLAEYNGRLAAELEDRRQLARMLVEYTQNQKDVLSEKEKKLEVDGQVVALLVQNLERLDESVKEEADGVHNTLAIVENMAEFRPEMCTEGAQQGLLQWLLKRLKAKM
PFDANKLYCSEVLAILLQDNDENRELLGELDGIDVLLQQLSVFKRHNPSTAEEQEMMENLFDSLCSCLMLSSNRERFLKGEGLQLMNLMLREKKISRSSALKVLDHAMIGPEGTDNCHKFVDILGLRTIFPLFMKSPRKIKKVGTTEKEH
EEHVCSILASLLRNLRGQQRTRLLNKFTENDSEKVDRLMELHFKYLGAMQVADKKIEGEKHDMVRRGEIIDNDTEEEFYLRRLDAGLFVLQHICYIMAEICNANVPQIRQRVHQILNMRGSSIKIVRHIIKEYAENIGDGRSPEFRENEQ
KRILGLLENF

>RPRD1B_CTNNBL1_ENST00000373433_ENST00000373473_36694658_36393598_5-gene_p.K143N_760_K251N length=760AA
MREVQSGRRLQRDGFLELRRLSVPLCSGPCPLTSLSRQGERSGGHLVAAARAAVTAETHPLPLLAPLAVCQSVKSPAACQVRPRPRAVALPAALGGPGRSLPGLTAATMSSFSESALEKKLSELSNSQQSVQTLSLWLIHHRKHAGPIVS
VWHRELRKAKSNRKLTFLYLANDVIQNSKRKGPEFTREFESVLVDAFSHVAREADEGCKKPLERLLNIWQERSVYGGEFIQQLKLSMEDSKSPPPKATEENKSLKRTFQQIQEEEDDDYPGSYSPQDPSAGPLLTEELIKALQDLENAAS
GDATVRQKIASLPQEVQDVSLLEKITDKEAAERLSKTVDEACLLLAEYNGRLAAELEDRRQLARMLVEYTQNQKDVLSEKEKKLEVDGQVVALLVQNLERLDESVKEEADGVHNTLAIVENMAEFRPEMCTEGAQQGLLQWLLKRLKAKM
PFDANKLYCSEVLAILLQDNDENRELLGELDGIDVLLQQLSVFKRHNPSTAEEQEMMENLFDSLCSCLMLSSNRERFLKGEGLQLMNLMLREKKISRSSALKVLDHAMIGPEGTDNCHKFVDILGLRTIFPLFMKSPRKIKKVGTTEKEH
EEHVCSILASLLRNLRGQQRTRLLNKFTENDSEKVDRLMELHFKYLGAMQVADKKIEGEKHDMVRRGEIIDNDTEEEFYLRRLDAGLFVLQHICYIMAEICNANVPQIRQRVHQILNMRGSSIKIVRHIIKEYAENIGDGRSPEFRENEQ
KRILGLLENF

>RPRD1B_CTNNBL1_ENST00000373433_ENST00000373473_36694658_36393598_5-gene_p.R243C_760_R351C length=760AA
MREVQSGRRLQRDGFLELRRLSVPLCSGPCPLTSLSRQGERSGGHLVAAARAAVTAETHPLPLLAPLAVCQSVKSPAACQVRPRPRAVALPAALGGPGRSLPGLTAATMSSFSESALEKKLSELSNSQQSVQTLSLWLIHHRKHAGPIVS
VWHRELRKAKSNRKLTFLYLANDVIQNSKRKGPEFTREFESVLVDAFSHVAREADEGCKKPLERLLNIWQERSVYGGEFIQQLKLSMEDSKSPPPKATEEKKSLKRTFQQIQEEEDDDYPGSYSPQDPSAGPLLTEELIKALQDLENAAS
GDATVRQKIASLPQEVQDVSLLEKITDKEAAERLSKTVDEACLLLAEYNGCLAAELEDRRQLARMLVEYTQNQKDVLSEKEKKLEVDGQVVALLVQNLERLDESVKEEADGVHNTLAIVENMAEFRPEMCTEGAQQGLLQWLLKRLKAKM
PFDANKLYCSEVLAILLQDNDENRELLGELDGIDVLLQQLSVFKRHNPSTAEEQEMMENLFDSLCSCLMLSSNRERFLKGEGLQLMNLMLREKKISRSSALKVLDHAMIGPEGTDNCHKFVDILGLRTIFPLFMKSPRKIKKVGTTEKEH
EEHVCSILASLLRNLRGQQRTRLLNKFTENDSEKVDRLMELHFKYLGAMQVADKKIEGEKHDMVRRGEIIDNDTEEEFYLRRLDAGLFVLQHICYIMAEICNANVPQIRQRVHQILNMRGSSIKIVRHIIKEYAENIGDGRSPEFRENEQ
KRILGLLENF

>RPRD1B_CTNNBL1_ENST00000373433_ENST00000373473_36694658_36393598_5-gene_p.A88D_760_A196D length=760AA
MREVQSGRRLQRDGFLELRRLSVPLCSGPCPLTSLSRQGERSGGHLVAAARAAVTAETHPLPLLAPLAVCQSVKSPAACQVRPRPRAVALPAALGGPGRSLPGLTAATMSSFSESALEKKLSELSNSQQSVQTLSLWLIHHRKHAGPIVS
VWHRELRKAKSNRKLTFLYLANDVIQNSKRKGPEFTREFESVLVDDFSHVAREADEGCKKPLERLLNIWQERSVYGGEFIQQLKLSMEDSKSPPPKATEEKKSLKRTFQQIQEEEDDDYPGSYSPQDPSAGPLLTEELIKALQDLENAAS
GDATVRQKIASLPQEVQDVSLLEKITDKEAAERLSKTVDEACLLLAEYNGRLAAELEDRRQLARMLVEYTQNQKDVLSEKEKKLEVDGQVVALLVQNLERLDESVKEEADGVHNTLAIVENMAEFRPEMCTEGAQQGLLQWLLKRLKAKM
PFDANKLYCSEVLAILLQDNDENRELLGELDGIDVLLQQLSVFKRHNPSTAEEQEMMENLFDSLCSCLMLSSNRERFLKGEGLQLMNLMLREKKISRSSALKVLDHAMIGPEGTDNCHKFVDILGLRTIFPLFMKSPRKIKKVGTTEKEH
EEHVCSILASLLRNLRGQQRTRLLNKFTENDSEKVDRLMELHFKYLGAMQVADKKIEGEKHDMVRRGEIIDNDTEEEFYLRRLDAGLFVLQHICYIMAEICNANVPQIRQRVHQILNMRGSSIKIVRHIIKEYAENIGDGRSPEFRENEQ
KRILGLLENF

>RPRD1B_CTNNBL1_ENST00000373433_ENST00000373473_36694658_36393598_5-gene_p.R251C_760_R359C length=760AA
MREVQSGRRLQRDGFLELRRLSVPLCSGPCPLTSLSRQGERSGGHLVAAARAAVTAETHPLPLLAPLAVCQSVKSPAACQVRPRPRAVALPAALGGPGRSLPGLTAATMSSFSESALEKKLSELSNSQQSVQTLSLWLIHHRKHAGPIVS
VWHRELRKAKSNRKLTFLYLANDVIQNSKRKGPEFTREFESVLVDAFSHVAREADEGCKKPLERLLNIWQERSVYGGEFIQQLKLSMEDSKSPPPKATEEKKSLKRTFQQIQEEEDDDYPGSYSPQDPSAGPLLTEELIKALQDLENAAS
GDATVRQKIASLPQEVQDVSLLEKITDKEAAERLSKTVDEACLLLAEYNGRLAAELEDCRQLARMLVEYTQNQKDVLSEKEKKLEVDGQVVALLVQNLERLDESVKEEADGVHNTLAIVENMAEFRPEMCTEGAQQGLLQWLLKRLKAKM
PFDANKLYCSEVLAILLQDNDENRELLGELDGIDVLLQQLSVFKRHNPSTAEEQEMMENLFDSLCSCLMLSSNRERFLKGEGLQLMNLMLREKKISRSSALKVLDHAMIGPEGTDNCHKFVDILGLRTIFPLFMKSPRKIKKVGTTEKEH
EEHVCSILASLLRNLRGQQRTRLLNKFTENDSEKVDRLMELHFKYLGAMQVADKKIEGEKHDMVRRGEIIDNDTEEEFYLRRLDAGLFVLQHICYIMAEICNANVPQIRQRVHQILNMRGSSIKIVRHIIKEYAENIGDGRSPEFRENEQ
KRILGLLENF

>RPRD1B_CTNNBL1_ENST00000373433_ENST00000373473_36694658_36393598_5-gene_p.A246V_760_A354V length=760AA
MREVQSGRRLQRDGFLELRRLSVPLCSGPCPLTSLSRQGERSGGHLVAAARAAVTAETHPLPLLAPLAVCQSVKSPAACQVRPRPRAVALPAALGGPGRSLPGLTAATMSSFSESALEKKLSELSNSQQSVQTLSLWLIHHRKHAGPIVS
VWHRELRKAKSNRKLTFLYLANDVIQNSKRKGPEFTREFESVLVDAFSHVAREADEGCKKPLERLLNIWQERSVYGGEFIQQLKLSMEDSKSPPPKATEEKKSLKRTFQQIQEEEDDDYPGSYSPQDPSAGPLLTEELIKALQDLENAAS
GDATVRQKIASLPQEVQDVSLLEKITDKEAAERLSKTVDEACLLLAEYNGRLAVELEDRRQLARMLVEYTQNQKDVLSEKEKKLEVDGQVVALLVQNLERLDESVKEEADGVHNTLAIVENMAEFRPEMCTEGAQQGLLQWLLKRLKAKM
PFDANKLYCSEVLAILLQDNDENRELLGELDGIDVLLQQLSVFKRHNPSTAEEQEMMENLFDSLCSCLMLSSNRERFLKGEGLQLMNLMLREKKISRSSALKVLDHAMIGPEGTDNCHKFVDILGLRTIFPLFMKSPRKIKKVGTTEKEH
EEHVCSILASLLRNLRGQQRTRLLNKFTENDSEKVDRLMELHFKYLGAMQVADKKIEGEKHDMVRRGEIIDNDTEEEFYLRRLDAGLFVLQHICYIMAEICNANVPQIRQRVHQILNMRGSSIKIVRHIIKEYAENIGDGRSPEFRENEQ
KRILGLLENF

>RPRD1B_CTNNBL1_ENST00000373433_ENST00000373473_36694658_36393598_5-gene_p.S203Y_760_S311Y length=760AA
MREVQSGRRLQRDGFLELRRLSVPLCSGPCPLTSLSRQGERSGGHLVAAARAAVTAETHPLPLLAPLAVCQSVKSPAACQVRPRPRAVALPAALGGPGRSLPGLTAATMSSFSESALEKKLSELSNSQQSVQTLSLWLIHHRKHAGPIVS
VWHRELRKAKSNRKLTFLYLANDVIQNSKRKGPEFTREFESVLVDAFSHVAREADEGCKKPLERLLNIWQERSVYGGEFIQQLKLSMEDSKSPPPKATEEKKSLKRTFQQIQEEEDDDYPGSYSPQDPSAGPLLTEELIKALQDLENAAS
GDATVRQKIAYLPQEVQDVSLLEKITDKEAAERLSKTVDEACLLLAEYNGRLAAELEDRRQLARMLVEYTQNQKDVLSEKEKKLEVDGQVVALLVQNLERLDESVKEEADGVHNTLAIVENMAEFRPEMCTEGAQQGLLQWLLKRLKAKM
PFDANKLYCSEVLAILLQDNDENRELLGELDGIDVLLQQLSVFKRHNPSTAEEQEMMENLFDSLCSCLMLSSNRERFLKGEGLQLMNLMLREKKISRSSALKVLDHAMIGPEGTDNCHKFVDILGLRTIFPLFMKSPRKIKKVGTTEKEH
EEHVCSILASLLRNLRGQQRTRLLNKFTENDSEKVDRLMELHFKYLGAMQVADKKIEGEKHDMVRRGEIIDNDTEEEFYLRRLDAGLFVLQHICYIMAEICNANVPQIRQRVHQILNMRGSSIKIVRHIIKEYAENIGDGRSPEFRENEQ
KRILGLLENF

>RPRD1B_CTNNBL1_ENST00000373433_ENST00000373473_36694658_36393598_5-gene_p.D97E_760_D205E length=760AA
MREVQSGRRLQRDGFLELRRLSVPLCSGPCPLTSLSRQGERSGGHLVAAARAAVTAETHPLPLLAPLAVCQSVKSPAACQVRPRPRAVALPAALGGPGRSLPGLTAATMSSFSESALEKKLSELSNSQQSVQTLSLWLIHHRKHAGPIVS
VWHRELRKAKSNRKLTFLYLANDVIQNSKRKGPEFTREFESVLVDAFSHVAREAEEGCKKPLERLLNIWQERSVYGGEFIQQLKLSMEDSKSPPPKATEEKKSLKRTFQQIQEEEDDDYPGSYSPQDPSAGPLLTEELIKALQDLENAAS
GDATVRQKIASLPQEVQDVSLLEKITDKEAAERLSKTVDEACLLLAEYNGRLAAELEDRRQLARMLVEYTQNQKDVLSEKEKKLEVDGQVVALLVQNLERLDESVKEEADGVHNTLAIVENMAEFRPEMCTEGAQQGLLQWLLKRLKAKM
PFDANKLYCSEVLAILLQDNDENRELLGELDGIDVLLQQLSVFKRHNPSTAEEQEMMENLFDSLCSCLMLSSNRERFLKGEGLQLMNLMLREKKISRSSALKVLDHAMIGPEGTDNCHKFVDILGLRTIFPLFMKSPRKIKKVGTTEKEH
EEHVCSILASLLRNLRGQQRTRLLNKFTENDSEKVDRLMELHFKYLGAMQVADKKIEGEKHDMVRRGEIIDNDTEEEFYLRRLDAGLFVLQHICYIMAEICNANVPQIRQRVHQILNMRGSSIKIVRHIIKEYAENIGDGRSPEFRENEQ
KRILGLLENF

>RPRD1B_CTNNBL1_ENST00000373433_ENST00000373473_36694658_36393598_5-gene_p.R198P_760_R306P length=760AA
MREVQSGRRLQRDGFLELRRLSVPLCSGPCPLTSLSRQGERSGGHLVAAARAAVTAETHPLPLLAPLAVCQSVKSPAACQVRPRPRAVALPAALGGPGRSLPGLTAATMSSFSESALEKKLSELSNSQQSVQTLSLWLIHHRKHAGPIVS
VWHRELRKAKSNRKLTFLYLANDVIQNSKRKGPEFTREFESVLVDAFSHVAREADEGCKKPLERLLNIWQERSVYGGEFIQQLKLSMEDSKSPPPKATEEKKSLKRTFQQIQEEEDDDYPGSYSPQDPSAGPLLTEELIKALQDLENAAS
GDATVPQKIASLPQEVQDVSLLEKITDKEAAERLSKTVDEACLLLAEYNGRLAAELEDRRQLARMLVEYTQNQKDVLSEKEKKLEVDGQVVALLVQNLERLDESVKEEADGVHNTLAIVENMAEFRPEMCTEGAQQGLLQWLLKRLKAKM
PFDANKLYCSEVLAILLQDNDENRELLGELDGIDVLLQQLSVFKRHNPSTAEEQEMMENLFDSLCSCLMLSSNRERFLKGEGLQLMNLMLREKKISRSSALKVLDHAMIGPEGTDNCHKFVDILGLRTIFPLFMKSPRKIKKVGTTEKEH
EEHVCSILASLLRNLRGQQRTRLLNKFTENDSEKVDRLMELHFKYLGAMQVADKKIEGEKHDMVRRGEIIDNDTEEEFYLRRLDAGLFVLQHICYIMAEICNANVPQIRQRVHQILNMRGSSIKIVRHIIKEYAENIGDGRSPEFRENEQ
KRILGLLENF

>RPRD1B_CTNNBL1_ENST00000373433_ENST00000373473_36694658_36393598_5-gene_p.Q253H_760_Q361H length=760AA
MREVQSGRRLQRDGFLELRRLSVPLCSGPCPLTSLSRQGERSGGHLVAAARAAVTAETHPLPLLAPLAVCQSVKSPAACQVRPRPRAVALPAALGGPGRSLPGLTAATMSSFSESALEKKLSELSNSQQSVQTLSLWLIHHRKHAGPIVS
VWHRELRKAKSNRKLTFLYLANDVIQNSKRKGPEFTREFESVLVDAFSHVAREADEGCKKPLERLLNIWQERSVYGGEFIQQLKLSMEDSKSPPPKATEEKKSLKRTFQQIQEEEDDDYPGSYSPQDPSAGPLLTEELIKALQDLENAAS
GDATVRQKIASLPQEVQDVSLLEKITDKEAAERLSKTVDEACLLLAEYNGRLAAELEDRRHLARMLVEYTQNQKDVLSEKEKKLEVDGQVVALLVQNLERLDESVKEEADGVHNTLAIVENMAEFRPEMCTEGAQQGLLQWLLKRLKAKM
PFDANKLYCSEVLAILLQDNDENRELLGELDGIDVLLQQLSVFKRHNPSTAEEQEMMENLFDSLCSCLMLSSNRERFLKGEGLQLMNLMLREKKISRSSALKVLDHAMIGPEGTDNCHKFVDILGLRTIFPLFMKSPRKIKKVGTTEKEH
EEHVCSILASLLRNLRGQQRTRLLNKFTENDSEKVDRLMELHFKYLGAMQVADKKIEGEKHDMVRRGEIIDNDTEEEFYLRRLDAGLFVLQHICYIMAEICNANVPQIRQRVHQILNMRGSSIKIVRHIIKEYAENIGDGRSPEFRENEQ
KRILGLLENF

>RPRD1B_CTNNBL1_ENST00000373433_ENST00000373473_36694658_36393598_5-gene_p.Q168R_760_Q276R length=760AA
MREVQSGRRLQRDGFLELRRLSVPLCSGPCPLTSLSRQGERSGGHLVAAARAAVTAETHPLPLLAPLAVCQSVKSPAACQVRPRPRAVALPAALGGPGRSLPGLTAATMSSFSESALEKKLSELSNSQQSVQTLSLWLIHHRKHAGPIVS
VWHRELRKAKSNRKLTFLYLANDVIQNSKRKGPEFTREFESVLVDAFSHVAREADEGCKKPLERLLNIWQERSVYGGEFIQQLKLSMEDSKSPPPKATEEKKSLKRTFQQIQEEEDDDYPGSYSPRDPSAGPLLTEELIKALQDLENAAS
GDATVRQKIASLPQEVQDVSLLEKITDKEAAERLSKTVDEACLLLAEYNGRLAAELEDRRQLARMLVEYTQNQKDVLSEKEKKLEVDGQVVALLVQNLERLDESVKEEADGVHNTLAIVENMAEFRPEMCTEGAQQGLLQWLLKRLKAKM
PFDANKLYCSEVLAILLQDNDENRELLGELDGIDVLLQQLSVFKRHNPSTAEEQEMMENLFDSLCSCLMLSSNRERFLKGEGLQLMNLMLREKKISRSSALKVLDHAMIGPEGTDNCHKFVDILGLRTIFPLFMKSPRKIKKVGTTEKEH
EEHVCSILASLLRNLRGQQRTRLLNKFTENDSEKVDRLMELHFKYLGAMQVADKKIEGEKHDMVRRGEIIDNDTEEEFYLRRLDAGLFVLQHICYIMAEICNANVPQIRQRVHQILNMRGSSIKIVRHIIKEYAENIGDGRSPEFRENEQ
KRILGLLENF

>RPRD1B_CTNNBL1_ENST00000373433_ENST00000373473_36694658_36393598_5-gene_p.N109K_760_N217K length=760AA
MREVQSGRRLQRDGFLELRRLSVPLCSGPCPLTSLSRQGERSGGHLVAAARAAVTAETHPLPLLAPLAVCQSVKSPAACQVRPRPRAVALPAALGGPGRSLPGLTAATMSSFSESALEKKLSELSNSQQSVQTLSLWLIHHRKHAGPIVS
VWHRELRKAKSNRKLTFLYLANDVIQNSKRKGPEFTREFESVLVDAFSHVAREADEGCKKPLERLLKIWQERSVYGGEFIQQLKLSMEDSKSPPPKATEEKKSLKRTFQQIQEEEDDDYPGSYSPQDPSAGPLLTEELIKALQDLENAAS
GDATVRQKIASLPQEVQDVSLLEKITDKEAAERLSKTVDEACLLLAEYNGRLAAELEDRRQLARMLVEYTQNQKDVLSEKEKKLEVDGQVVALLVQNLERLDESVKEEADGVHNTLAIVENMAEFRPEMCTEGAQQGLLQWLLKRLKAKM
PFDANKLYCSEVLAILLQDNDENRELLGELDGIDVLLQQLSVFKRHNPSTAEEQEMMENLFDSLCSCLMLSSNRERFLKGEGLQLMNLMLREKKISRSSALKVLDHAMIGPEGTDNCHKFVDILGLRTIFPLFMKSPRKIKKVGTTEKEH
EEHVCSILASLLRNLRGQQRTRLLNKFTENDSEKVDRLMELHFKYLGAMQVADKKIEGEKHDMVRRGEIIDNDTEEEFYLRRLDAGLFVLQHICYIMAEICNANVPQIRQRVHQILNMRGSSIKIVRHIIKEYAENIGDGRSPEFRENEQ
KRILGLLENF

>RPRD1B_CTNNBL1_ENST00000373433_ENST00000373473_36694658_36393598_5-gene_p.P170T_760_P278T length=760AA
MREVQSGRRLQRDGFLELRRLSVPLCSGPCPLTSLSRQGERSGGHLVAAARAAVTAETHPLPLLAPLAVCQSVKSPAACQVRPRPRAVALPAALGGPGRSLPGLTAATMSSFSESALEKKLSELSNSQQSVQTLSLWLIHHRKHAGPIVS
VWHRELRKAKSNRKLTFLYLANDVIQNSKRKGPEFTREFESVLVDAFSHVAREADEGCKKPLERLLNIWQERSVYGGEFIQQLKLSMEDSKSPPPKATEEKKSLKRTFQQIQEEEDDDYPGSYSPQDTSAGPLLTEELIKALQDLENAAS
GDATVRQKIASLPQEVQDVSLLEKITDKEAAERLSKTVDEACLLLAEYNGRLAAELEDRRQLARMLVEYTQNQKDVLSEKEKKLEVDGQVVALLVQNLERLDESVKEEADGVHNTLAIVENMAEFRPEMCTEGAQQGLLQWLLKRLKAKM
PFDANKLYCSEVLAILLQDNDENRELLGELDGIDVLLQQLSVFKRHNPSTAEEQEMMENLFDSLCSCLMLSSNRERFLKGEGLQLMNLMLREKKISRSSALKVLDHAMIGPEGTDNCHKFVDILGLRTIFPLFMKSPRKIKKVGTTEKEH
EEHVCSILASLLRNLRGQQRTRLLNKFTENDSEKVDRLMELHFKYLGAMQVADKKIEGEKHDMVRRGEIIDNDTEEEFYLRRLDAGLFVLQHICYIMAEICNANVPQIRQRVHQILNMRGSSIKIVRHIIKEYAENIGDGRSPEFRENEQ
KRILGLLENF

>RPRD1B_CTNNBL1_ENST00000373433_ENST00000373473_36694658_36393598_5-gene_p.K216N_760_K324N length=760AA
MREVQSGRRLQRDGFLELRRLSVPLCSGPCPLTSLSRQGERSGGHLVAAARAAVTAETHPLPLLAPLAVCQSVKSPAACQVRPRPRAVALPAALGGPGRSLPGLTAATMSSFSESALEKKLSELSNSQQSVQTLSLWLIHHRKHAGPIVS
VWHRELRKAKSNRKLTFLYLANDVIQNSKRKGPEFTREFESVLVDAFSHVAREADEGCKKPLERLLNIWQERSVYGGEFIQQLKLSMEDSKSPPPKATEEKKSLKRTFQQIQEEEDDDYPGSYSPQDPSAGPLLTEELIKALQDLENAAS
GDATVRQKIASLPQEVQDVSLLENITDKEAAERLSKTVDEACLLLAEYNGRLAAELEDRRQLARMLVEYTQNQKDVLSEKEKKLEVDGQVVALLVQNLERLDESVKEEADGVHNTLAIVENMAEFRPEMCTEGAQQGLLQWLLKRLKAKM
PFDANKLYCSEVLAILLQDNDENRELLGELDGIDVLLQQLSVFKRHNPSTAEEQEMMENLFDSLCSCLMLSSNRERFLKGEGLQLMNLMLREKKISRSSALKVLDHAMIGPEGTDNCHKFVDILGLRTIFPLFMKSPRKIKKVGTTEKEH
EEHVCSILASLLRNLRGQQRTRLLNKFTENDSEKVDRLMELHFKYLGAMQVADKKIEGEKHDMVRRGEIIDNDTEEEFYLRRLDAGLFVLQHICYIMAEICNANVPQIRQRVHQILNMRGSSIKIVRHIIKEYAENIGDGRSPEFRENEQ
KRILGLLENF

>RPRD1B_CTNNBL1_ENST00000373433_ENST00000373473_36694658_36393598_5-gene_p.V211A_760_V319A length=760AA
MREVQSGRRLQRDGFLELRRLSVPLCSGPCPLTSLSRQGERSGGHLVAAARAAVTAETHPLPLLAPLAVCQSVKSPAACQVRPRPRAVALPAALGGPGRSLPGLTAATMSSFSESALEKKLSELSNSQQSVQTLSLWLIHHRKHAGPIVS
VWHRELRKAKSNRKLTFLYLANDVIQNSKRKGPEFTREFESVLVDAFSHVAREADEGCKKPLERLLNIWQERSVYGGEFIQQLKLSMEDSKSPPPKATEEKKSLKRTFQQIQEEEDDDYPGSYSPQDPSAGPLLTEELIKALQDLENAAS
GDATVRQKIASLPQEVQDASLLEKITDKEAAERLSKTVDEACLLLAEYNGRLAAELEDRRQLARMLVEYTQNQKDVLSEKEKKLEVDGQVVALLVQNLERLDESVKEEADGVHNTLAIVENMAEFRPEMCTEGAQQGLLQWLLKRLKAKM
PFDANKLYCSEVLAILLQDNDENRELLGELDGIDVLLQQLSVFKRHNPSTAEEQEMMENLFDSLCSCLMLSSNRERFLKGEGLQLMNLMLREKKISRSSALKVLDHAMIGPEGTDNCHKFVDILGLRTIFPLFMKSPRKIKKVGTTEKEH
EEHVCSILASLLRNLRGQQRTRLLNKFTENDSEKVDRLMELHFKYLGAMQVADKKIEGEKHDMVRRGEIIDNDTEEEFYLRRLDAGLFVLQHICYIMAEICNANVPQIRQRVHQILNMRGSSIKIVRHIIKEYAENIGDGRSPEFRENEQ
KRILGLLENF

>RPRD1B_CTNNBL1_ENST00000373433_ENST00000373473_36694658_36393598_5-gene_p.S19C_760_S127C length=760AA
MREVQSGRRLQRDGFLELRRLSVPLCSGPCPLTSLSRQGERSGGHLVAAARAAVTAETHPLPLLAPLAVCQSVKSPAACQVRPRPRAVALPAALGGPGRSLPGLTAATMSSFSESALEKKLSELSNCQQSVQTLSLWLIHHRKHAGPIVS
VWHRELRKAKSNRKLTFLYLANDVIQNSKRKGPEFTREFESVLVDAFSHVAREADEGCKKPLERLLNIWQERSVYGGEFIQQLKLSMEDSKSPPPKATEEKKSLKRTFQQIQEEEDDDYPGSYSPQDPSAGPLLTEELIKALQDLENAAS
GDATVRQKIASLPQEVQDVSLLEKITDKEAAERLSKTVDEACLLLAEYNGRLAAELEDRRQLARMLVEYTQNQKDVLSEKEKKLEVDGQVVALLVQNLERLDESVKEEADGVHNTLAIVENMAEFRPEMCTEGAQQGLLQWLLKRLKAKM
PFDANKLYCSEVLAILLQDNDENRELLGELDGIDVLLQQLSVFKRHNPSTAEEQEMMENLFDSLCSCLMLSSNRERFLKGEGLQLMNLMLREKKISRSSALKVLDHAMIGPEGTDNCHKFVDILGLRTIFPLFMKSPRKIKKVGTTEKEH
EEHVCSILASLLRNLRGQQRTRLLNKFTENDSEKVDRLMELHFKYLGAMQVADKKIEGEKHDMVRRGEIIDNDTEEEFYLRRLDAGLFVLQHICYIMAEICNANVPQIRQRVHQILNMRGSSIKIVRHIIKEYAENIGDGRSPEFRENEQ
KRILGLLENF

>RPRD1B_CTNNBL1_ENST00000373433_ENST00000373473_36694658_36393598_5-gene_p.A238S_760_A346S length=760AA
MREVQSGRRLQRDGFLELRRLSVPLCSGPCPLTSLSRQGERSGGHLVAAARAAVTAETHPLPLLAPLAVCQSVKSPAACQVRPRPRAVALPAALGGPGRSLPGLTAATMSSFSESALEKKLSELSNSQQSVQTLSLWLIHHRKHAGPIVS
VWHRELRKAKSNRKLTFLYLANDVIQNSKRKGPEFTREFESVLVDAFSHVAREADEGCKKPLERLLNIWQERSVYGGEFIQQLKLSMEDSKSPPPKATEEKKSLKRTFQQIQEEEDDDYPGSYSPQDPSAGPLLTEELIKALQDLENAAS
GDATVRQKIASLPQEVQDVSLLEKITDKEAAERLSKTVDEACLLLSEYNGRLAAELEDRRQLARMLVEYTQNQKDVLSEKEKKLEVDGQVVALLVQNLERLDESVKEEADGVHNTLAIVENMAEFRPEMCTEGAQQGLLQWLLKRLKAKM
PFDANKLYCSEVLAILLQDNDENRELLGELDGIDVLLQQLSVFKRHNPSTAEEQEMMENLFDSLCSCLMLSSNRERFLKGEGLQLMNLMLREKKISRSSALKVLDHAMIGPEGTDNCHKFVDILGLRTIFPLFMKSPRKIKKVGTTEKEH
EEHVCSILASLLRNLRGQQRTRLLNKFTENDSEKVDRLMELHFKYLGAMQVADKKIEGEKHDMVRRGEIIDNDTEEEFYLRRLDAGLFVLQHICYIMAEICNANVPQIRQRVHQILNMRGSSIKIVRHIIKEYAENIGDGRSPEFRENEQ
KRILGLLENF

>RPRD1B_CTNNBL1_ENST00000373433_ENST00000373473_36694658_36393598_5-gene_p.R106I_760_R214I length=760AA
MREVQSGRRLQRDGFLELRRLSVPLCSGPCPLTSLSRQGERSGGHLVAAARAAVTAETHPLPLLAPLAVCQSVKSPAACQVRPRPRAVALPAALGGPGRSLPGLTAATMSSFSESALEKKLSELSNSQQSVQTLSLWLIHHRKHAGPIVS
VWHRELRKAKSNRKLTFLYLANDVIQNSKRKGPEFTREFESVLVDAFSHVAREADEGCKKPLEILLNIWQERSVYGGEFIQQLKLSMEDSKSPPPKATEEKKSLKRTFQQIQEEEDDDYPGSYSPQDPSAGPLLTEELIKALQDLENAAS
GDATVRQKIASLPQEVQDVSLLEKITDKEAAERLSKTVDEACLLLAEYNGRLAAELEDRRQLARMLVEYTQNQKDVLSEKEKKLEVDGQVVALLVQNLERLDESVKEEADGVHNTLAIVENMAEFRPEMCTEGAQQGLLQWLLKRLKAKM
PFDANKLYCSEVLAILLQDNDENRELLGELDGIDVLLQQLSVFKRHNPSTAEEQEMMENLFDSLCSCLMLSSNRERFLKGEGLQLMNLMLREKKISRSSALKVLDHAMIGPEGTDNCHKFVDILGLRTIFPLFMKSPRKIKKVGTTEKEH
EEHVCSILASLLRNLRGQQRTRLLNKFTENDSEKVDRLMELHFKYLGAMQVADKKIEGEKHDMVRRGEIIDNDTEEEFYLRRLDAGLFVLQHICYIMAEICNANVPQIRQRVHQILNMRGSSIKIVRHIIKEYAENIGDGRSPEFRENEQ
KRILGLLENF

>RPRD1B_CTNNBL1_ENST00000373433_ENST00000373473_36694658_36393598_5-gene_p.R243C_760_R351C length=760AA
MREVQSGRRLQRDGFLELRRLSVPLCSGPCPLTSLSRQGERSGGHLVAAARAAVTAETHPLPLLAPLAVCQSVKSPAACQVRPRPRAVALPAALGGPGRSLPGLTAATMSSFSESALEKKLSELSNSQQSVQTLSLWLIHHRKHAGPIVS
VWHRELRKAKSNRKLTFLYLANDVIQNSKRKGPEFTREFESVLVDAFSHVAREADEGCKKPLERLLNIWQERSVYGGEFIQQLKLSMEDSKSPPPKATEEKKSLKRTFQQIQEEEDDDYPGSYSPQDPSAGPLLTEELIKALQDLENAAS
GDATVRQKIASLPQEVQDVSLLEKITDKEAAERLSKTVDEACLLLAEYNGCLAAELEDRRQLARMLVEYTQNQKDVLSEKEKKLEVDGQVVALLVQNLERLDESVKEEADGVHNTLAIVENMAEFRPEMCTEGAQQGLLQWLLKRLKAKM
PFDANKLYCSEVLAILLQDNDENRELLGELDGIDVLLQQLSVFKRHNPSTAEEQEMMENLFDSLCSCLMLSSNRERFLKGEGLQLMNLMLREKKISRSSALKVLDHAMIGPEGTDNCHKFVDILGLRTIFPLFMKSPRKIKKVGTTEKEH
EEHVCSILASLLRNLRGQQRTRLLNKFTENDSEKVDRLMELHFKYLGAMQVADKKIEGEKHDMVRRGEIIDNDTEEEFYLRRLDAGLFVLQHICYIMAEICNANVPQIRQRVHQILNMRGSSIKIVRHIIKEYAENIGDGRSPEFRENEQ
KRILGLLENF

>RPRD1B_CTNNBL1_ENST00000373433_ENST00000373473_36694658_36393598_5-gene_p.H45R_760_H153R length=760AA
MREVQSGRRLQRDGFLELRRLSVPLCSGPCPLTSLSRQGERSGGHLVAAARAAVTAETHPLPLLAPLAVCQSVKSPAACQVRPRPRAVALPAALGGPGRSLPGLTAATMSSFSESALEKKLSELSNSQQSVQTLSLWLIHHRKHAGPIVS
VWRRELRKAKSNRKLTFLYLANDVIQNSKRKGPEFTREFESVLVDAFSHVAREADEGCKKPLERLLNIWQERSVYGGEFIQQLKLSMEDSKSPPPKATEEKKSLKRTFQQIQEEEDDDYPGSYSPQDPSAGPLLTEELIKALQDLENAAS
GDATVRQKIASLPQEVQDVSLLEKITDKEAAERLSKTVDEACLLLAEYNGRLAAELEDRRQLARMLVEYTQNQKDVLSEKEKKLEVDGQVVALLVQNLERLDESVKEEADGVHNTLAIVENMAEFRPEMCTEGAQQGLLQWLLKRLKAKM
PFDANKLYCSEVLAILLQDNDENRELLGELDGIDVLLQQLSVFKRHNPSTAEEQEMMENLFDSLCSCLMLSSNRERFLKGEGLQLMNLMLREKKISRSSALKVLDHAMIGPEGTDNCHKFVDILGLRTIFPLFMKSPRKIKKVGTTEKEH
EEHVCSILASLLRNLRGQQRTRLLNKFTENDSEKVDRLMELHFKYLGAMQVADKKIEGEKHDMVRRGEIIDNDTEEEFYLRRLDAGLFVLQHICYIMAEICNANVPQIRQRVHQILNMRGSSIKIVRHIIKEYAENIGDGRSPEFRENEQ
KRILGLLENF

>RPRD1B_CTNNBL1_ENST00000373433_ENST00000373473_36694658_36393598_5-gene_p.I67M_760_I175M length=760AA
MREVQSGRRLQRDGFLELRRLSVPLCSGPCPLTSLSRQGERSGGHLVAAARAAVTAETHPLPLLAPLAVCQSVKSPAACQVRPRPRAVALPAALGGPGRSLPGLTAATMSSFSESALEKKLSELSNSQQSVQTLSLWLIHHRKHAGPIVS
VWHRELRKAKSNRKLTFLYLANDVMQNSKRKGPEFTREFESVLVDAFSHVAREADEGCKKPLERLLNIWQERSVYGGEFIQQLKLSMEDSKSPPPKATEEKKSLKRTFQQIQEEEDDDYPGSYSPQDPSAGPLLTEELIKALQDLENAAS
GDATVRQKIASLPQEVQDVSLLEKITDKEAAERLSKTVDEACLLLAEYNGRLAAELEDRRQLARMLVEYTQNQKDVLSEKEKKLEVDGQVVALLVQNLERLDESVKEEADGVHNTLAIVENMAEFRPEMCTEGAQQGLLQWLLKRLKAKM
PFDANKLYCSEVLAILLQDNDENRELLGELDGIDVLLQQLSVFKRHNPSTAEEQEMMENLFDSLCSCLMLSSNRERFLKGEGLQLMNLMLREKKISRSSALKVLDHAMIGPEGTDNCHKFVDILGLRTIFPLFMKSPRKIKKVGTTEKEH
EEHVCSILASLLRNLRGQQRTRLLNKFTENDSEKVDRLMELHFKYLGAMQVADKKIEGEKHDMVRRGEIIDNDTEEEFYLRRLDAGLFVLQHICYIMAEICNANVPQIRQRVHQILNMRGSSIKIVRHIIKEYAENIGDGRSPEFRENEQ
KRILGLLENF

>RPRD1B_CTNNBL1_ENST00000373433_ENST00000373473_36694658_36393598_5-gene_p.R243C_760_R351C length=760AA
MREVQSGRRLQRDGFLELRRLSVPLCSGPCPLTSLSRQGERSGGHLVAAARAAVTAETHPLPLLAPLAVCQSVKSPAACQVRPRPRAVALPAALGGPGRSLPGLTAATMSSFSESALEKKLSELSNSQQSVQTLSLWLIHHRKHAGPIVS
VWHRELRKAKSNRKLTFLYLANDVIQNSKRKGPEFTREFESVLVDAFSHVAREADEGCKKPLERLLNIWQERSVYGGEFIQQLKLSMEDSKSPPPKATEEKKSLKRTFQQIQEEEDDDYPGSYSPQDPSAGPLLTEELIKALQDLENAAS
GDATVRQKIASLPQEVQDVSLLEKITDKEAAERLSKTVDEACLLLAEYNGCLAAELEDRRQLARMLVEYTQNQKDVLSEKEKKLEVDGQVVALLVQNLERLDESVKEEADGVHNTLAIVENMAEFRPEMCTEGAQQGLLQWLLKRLKAKM
PFDANKLYCSEVLAILLQDNDENRELLGELDGIDVLLQQLSVFKRHNPSTAEEQEMMENLFDSLCSCLMLSSNRERFLKGEGLQLMNLMLREKKISRSSALKVLDHAMIGPEGTDNCHKFVDILGLRTIFPLFMKSPRKIKKVGTTEKEH
EEHVCSILASLLRNLRGQQRTRLLNKFTENDSEKVDRLMELHFKYLGAMQVADKKIEGEKHDMVRRGEIIDNDTEEEFYLRRLDAGLFVLQHICYIMAEICNANVPQIRQRVHQILNMRGSSIKIVRHIIKEYAENIGDGRSPEFRENEQ
KRILGLLENF

>RPRD1B_CTNNBL1_ENST00000373433_ENST00000373473_36694658_36393598_5-gene_p.P137L_760_P245L length=760AA
MREVQSGRRLQRDGFLELRRLSVPLCSGPCPLTSLSRQGERSGGHLVAAARAAVTAETHPLPLLAPLAVCQSVKSPAACQVRPRPRAVALPAALGGPGRSLPGLTAATMSSFSESALEKKLSELSNSQQSVQTLSLWLIHHRKHAGPIVS
VWHRELRKAKSNRKLTFLYLANDVIQNSKRKGPEFTREFESVLVDAFSHVAREADEGCKKPLERLLNIWQERSVYGGEFIQQLKLSMEDSKSPPLKATEEKKSLKRTFQQIQEEEDDDYPGSYSPQDPSAGPLLTEELIKALQDLENAAS
GDATVRQKIASLPQEVQDVSLLEKITDKEAAERLSKTVDEACLLLAEYNGRLAAELEDRRQLARMLVEYTQNQKDVLSEKEKKLEVDGQVVALLVQNLERLDESVKEEADGVHNTLAIVENMAEFRPEMCTEGAQQGLLQWLLKRLKAKM
PFDANKLYCSEVLAILLQDNDENRELLGELDGIDVLLQQLSVFKRHNPSTAEEQEMMENLFDSLCSCLMLSSNRERFLKGEGLQLMNLMLREKKISRSSALKVLDHAMIGPEGTDNCHKFVDILGLRTIFPLFMKSPRKIKKVGTTEKEH
EEHVCSILASLLRNLRGQQRTRLLNKFTENDSEKVDRLMELHFKYLGAMQVADKKIEGEKHDMVRRGEIIDNDTEEEFYLRRLDAGLFVLQHICYIMAEICNANVPQIRQRVHQILNMRGSSIKIVRHIIKEYAENIGDGRSPEFRENEQ
KRILGLLENF

>RPRD1B_CTNNBL1_ENST00000373433_ENST00000373473_36694658_36393598_5-gene_p.S17C_760_S125C length=760AA
MREVQSGRRLQRDGFLELRRLSVPLCSGPCPLTSLSRQGERSGGHLVAAARAAVTAETHPLPLLAPLAVCQSVKSPAACQVRPRPRAVALPAALGGPGRSLPGLTAATMSSFSESALEKKLSELCNSQQSVQTLSLWLIHHRKHAGPIVS
VWHRELRKAKSNRKLTFLYLANDVIQNSKRKGPEFTREFESVLVDAFSHVAREADEGCKKPLERLLNIWQERSVYGGEFIQQLKLSMEDSKSPPPKATEEKKSLKRTFQQIQEEEDDDYPGSYSPQDPSAGPLLTEELIKALQDLENAAS
GDATVRQKIASLPQEVQDVSLLEKITDKEAAERLSKTVDEACLLLAEYNGRLAAELEDRRQLARMLVEYTQNQKDVLSEKEKKLEVDGQVVALLVQNLERLDESVKEEADGVHNTLAIVENMAEFRPEMCTEGAQQGLLQWLLKRLKAKM
PFDANKLYCSEVLAILLQDNDENRELLGELDGIDVLLQQLSVFKRHNPSTAEEQEMMENLFDSLCSCLMLSSNRERFLKGEGLQLMNLMLREKKISRSSALKVLDHAMIGPEGTDNCHKFVDILGLRTIFPLFMKSPRKIKKVGTTEKEH
EEHVCSILASLLRNLRGQQRTRLLNKFTENDSEKVDRLMELHFKYLGAMQVADKKIEGEKHDMVRRGEIIDNDTEEEFYLRRLDAGLFVLQHICYIMAEICNANVPQIRQRVHQILNMRGSSIKIVRHIIKEYAENIGDGRSPEFRENEQ
KRILGLLENF

>RPRD1B_CTNNBL1_ENST00000373433_ENST00000373473_36694658_36393598_5-gene_p.P75S_760_P183S length=760AA
MREVQSGRRLQRDGFLELRRLSVPLCSGPCPLTSLSRQGERSGGHLVAAARAAVTAETHPLPLLAPLAVCQSVKSPAACQVRPRPRAVALPAALGGPGRSLPGLTAATMSSFSESALEKKLSELSNSQQSVQTLSLWLIHHRKHAGPIVS
VWHRELRKAKSNRKLTFLYLANDVIQNSKRKGSEFTREFESVLVDAFSHVAREADEGCKKPLERLLNIWQERSVYGGEFIQQLKLSMEDSKSPPPKATEEKKSLKRTFQQIQEEEDDDYPGSYSPQDPSAGPLLTEELIKALQDLENAAS
GDATVRQKIASLPQEVQDVSLLEKITDKEAAERLSKTVDEACLLLAEYNGRLAAELEDRRQLARMLVEYTQNQKDVLSEKEKKLEVDGQVVALLVQNLERLDESVKEEADGVHNTLAIVENMAEFRPEMCTEGAQQGLLQWLLKRLKAKM
PFDANKLYCSEVLAILLQDNDENRELLGELDGIDVLLQQLSVFKRHNPSTAEEQEMMENLFDSLCSCLMLSSNRERFLKGEGLQLMNLMLREKKISRSSALKVLDHAMIGPEGTDNCHKFVDILGLRTIFPLFMKSPRKIKKVGTTEKEH
EEHVCSILASLLRNLRGQQRTRLLNKFTENDSEKVDRLMELHFKYLGAMQVADKKIEGEKHDMVRRGEIIDNDTEEEFYLRRLDAGLFVLQHICYIMAEICNANVPQIRQRVHQILNMRGSSIKIVRHIIKEYAENIGDGRSPEFRENEQ
KRILGLLENF

>RPRD1B_CTNNBL1_ENST00000373433_ENST00000373473_36694658_36393598_5-gene_p.E98K_760_E206K length=760AA
MREVQSGRRLQRDGFLELRRLSVPLCSGPCPLTSLSRQGERSGGHLVAAARAAVTAETHPLPLLAPLAVCQSVKSPAACQVRPRPRAVALPAALGGPGRSLPGLTAATMSSFSESALEKKLSELSNSQQSVQTLSLWLIHHRKHAGPIVS
VWHRELRKAKSNRKLTFLYLANDVIQNSKRKGPEFTREFESVLVDAFSHVAREADKGCKKPLERLLNIWQERSVYGGEFIQQLKLSMEDSKSPPPKATEEKKSLKRTFQQIQEEEDDDYPGSYSPQDPSAGPLLTEELIKALQDLENAAS
GDATVRQKIASLPQEVQDVSLLEKITDKEAAERLSKTVDEACLLLAEYNGRLAAELEDRRQLARMLVEYTQNQKDVLSEKEKKLEVDGQVVALLVQNLERLDESVKEEADGVHNTLAIVENMAEFRPEMCTEGAQQGLLQWLLKRLKAKM
PFDANKLYCSEVLAILLQDNDENRELLGELDGIDVLLQQLSVFKRHNPSTAEEQEMMENLFDSLCSCLMLSSNRERFLKGEGLQLMNLMLREKKISRSSALKVLDHAMIGPEGTDNCHKFVDILGLRTIFPLFMKSPRKIKKVGTTEKEH
EEHVCSILASLLRNLRGQQRTRLLNKFTENDSEKVDRLMELHFKYLGAMQVADKKIEGEKHDMVRRGEIIDNDTEEEFYLRRLDAGLFVLQHICYIMAEICNANVPQIRQRVHQILNMRGSSIKIVRHIIKEYAENIGDGRSPEFRENEQ
KRILGLLENF

>RPRD1B_CTNNBL1_ENST00000373433_ENST00000405275_36694658_36393598_5-gene_p.S128P_760_S236P length=760AA
MREVQSGRRLQRDGFLELRRLSVPLCSGPCPLTSLSRQGERSGGHLVAAARAAVTAETHPLPLLAPLAVCQSVKSPAACQVRPRPRAVALPAALGGPGRSLPGLTAATMSSFSESALEKKLSELSNSQQSVQTLSLWLIHHRKHAGPIVS
VWHRELRKAKSNRKLTFLYLANDVIQNSKRKGPEFTREFESVLVDAFSHVAREADEGCKKPLERLLNIWQERSVYGGEFIQQLKLPMEDSKSPPPKATEEKKSLKRTFQQIQEEEDDDYPGSYSPQDPSAGPLLTEELIKALQDLENAAS
GDATVRQKIASLPQEVQDVSLLEKITDKEAAERLSKTVDEACLLLAEYNGRLAAELEDRRQLARMLVEYTQNQKDVLSEKEKKLEVDGQVVALLVQNLERLDESVKEEADGVHNTLAIVENMAEFRPEMCTEGAQQGLLQWLLKRLKAKM
PFDANKLYCSEVLAILLQDNDENRELLGELDGIDVLLQQLSVFKRHNPSTAEEQEMMENLFDSLCSCLMLSSNRERFLKGEGLQLMNLMLREKKISRSSALKVLDHAMIGPEGTDNCHKFVDILGLRTIFPLFMKSPRKIKKVGTTEKEH
EEHVCSILASLLRNLRGQQRTRLLNKFTENDSEKVDRLMELHFKYLGAMQVADKKIEGEKHDMVRRGEIIDNDTEEEFYLRRLDAGLFVLQHICYIMAEICNANVPQIRQRVHQILNMRGSSIKIVRHIIKEYAENIGDGRSPEFRENEQ
KRILGLLENF

>RPRD1B_CTNNBL1_ENST00000373433_ENST00000405275_36694658_36393598_5-gene_p.G119C_760_G227C length=760AA
MREVQSGRRLQRDGFLELRRLSVPLCSGPCPLTSLSRQGERSGGHLVAAARAAVTAETHPLPLLAPLAVCQSVKSPAACQVRPRPRAVALPAALGGPGRSLPGLTAATMSSFSESALEKKLSELSNSQQSVQTLSLWLIHHRKHAGPIVS
VWHRELRKAKSNRKLTFLYLANDVIQNSKRKGPEFTREFESVLVDAFSHVAREADEGCKKPLERLLNIWQERSVYGCEFIQQLKLSMEDSKSPPPKATEEKKSLKRTFQQIQEEEDDDYPGSYSPQDPSAGPLLTEELIKALQDLENAAS
GDATVRQKIASLPQEVQDVSLLEKITDKEAAERLSKTVDEACLLLAEYNGRLAAELEDRRQLARMLVEYTQNQKDVLSEKEKKLEVDGQVVALLVQNLERLDESVKEEADGVHNTLAIVENMAEFRPEMCTEGAQQGLLQWLLKRLKAKM
PFDANKLYCSEVLAILLQDNDENRELLGELDGIDVLLQQLSVFKRHNPSTAEEQEMMENLFDSLCSCLMLSSNRERFLKGEGLQLMNLMLREKKISRSSALKVLDHAMIGPEGTDNCHKFVDILGLRTIFPLFMKSPRKIKKVGTTEKEH
EEHVCSILASLLRNLRGQQRTRLLNKFTENDSEKVDRLMELHFKYLGAMQVADKKIEGEKHDMVRRGEIIDNDTEEEFYLRRLDAGLFVLQHICYIMAEICNANVPQIRQRVHQILNMRGSSIKIVRHIIKEYAENIGDGRSPEFRENEQ
KRILGLLENF

>RPRD1B_CTNNBL1_ENST00000373433_ENST00000405275_36694658_36393598_5-gene_p.R251H_760_R359H length=760AA
MREVQSGRRLQRDGFLELRRLSVPLCSGPCPLTSLSRQGERSGGHLVAAARAAVTAETHPLPLLAPLAVCQSVKSPAACQVRPRPRAVALPAALGGPGRSLPGLTAATMSSFSESALEKKLSELSNSQQSVQTLSLWLIHHRKHAGPIVS
VWHRELRKAKSNRKLTFLYLANDVIQNSKRKGPEFTREFESVLVDAFSHVAREADEGCKKPLERLLNIWQERSVYGGEFIQQLKLSMEDSKSPPPKATEEKKSLKRTFQQIQEEEDDDYPGSYSPQDPSAGPLLTEELIKALQDLENAAS
GDATVRQKIASLPQEVQDVSLLEKITDKEAAERLSKTVDEACLLLAEYNGRLAAELEDHRQLARMLVEYTQNQKDVLSEKEKKLEVDGQVVALLVQNLERLDESVKEEADGVHNTLAIVENMAEFRPEMCTEGAQQGLLQWLLKRLKAKM
PFDANKLYCSEVLAILLQDNDENRELLGELDGIDVLLQQLSVFKRHNPSTAEEQEMMENLFDSLCSCLMLSSNRERFLKGEGLQLMNLMLREKKISRSSALKVLDHAMIGPEGTDNCHKFVDILGLRTIFPLFMKSPRKIKKVGTTEKEH
EEHVCSILASLLRNLRGQQRTRLLNKFTENDSEKVDRLMELHFKYLGAMQVADKKIEGEKHDMVRRGEIIDNDTEEEFYLRRLDAGLFVLQHICYIMAEICNANVPQIRQRVHQILNMRGSSIKIVRHIIKEYAENIGDGRSPEFRENEQ
KRILGLLENF

>RPRD1B_CTNNBL1_ENST00000373433_ENST00000405275_36694658_36393598_5-gene_p.R243L_760_R351L length=760AA
MREVQSGRRLQRDGFLELRRLSVPLCSGPCPLTSLSRQGERSGGHLVAAARAAVTAETHPLPLLAPLAVCQSVKSPAACQVRPRPRAVALPAALGGPGRSLPGLTAATMSSFSESALEKKLSELSNSQQSVQTLSLWLIHHRKHAGPIVS
VWHRELRKAKSNRKLTFLYLANDVIQNSKRKGPEFTREFESVLVDAFSHVAREADEGCKKPLERLLNIWQERSVYGGEFIQQLKLSMEDSKSPPPKATEEKKSLKRTFQQIQEEEDDDYPGSYSPQDPSAGPLLTEELIKALQDLENAAS
GDATVRQKIASLPQEVQDVSLLEKITDKEAAERLSKTVDEACLLLAEYNGLLAAELEDRRQLARMLVEYTQNQKDVLSEKEKKLEVDGQVVALLVQNLERLDESVKEEADGVHNTLAIVENMAEFRPEMCTEGAQQGLLQWLLKRLKAKM
PFDANKLYCSEVLAILLQDNDENRELLGELDGIDVLLQQLSVFKRHNPSTAEEQEMMENLFDSLCSCLMLSSNRERFLKGEGLQLMNLMLREKKISRSSALKVLDHAMIGPEGTDNCHKFVDILGLRTIFPLFMKSPRKIKKVGTTEKEH
EEHVCSILASLLRNLRGQQRTRLLNKFTENDSEKVDRLMELHFKYLGAMQVADKKIEGEKHDMVRRGEIIDNDTEEEFYLRRLDAGLFVLQHICYIMAEICNANVPQIRQRVHQILNMRGSSIKIVRHIIKEYAENIGDGRSPEFRENEQ
KRILGLLENF

>RPRD1B_CTNNBL1_ENST00000373433_ENST00000405275_36694658_36393598_5-gene_p.H32Y_760_H140Y length=760AA
MREVQSGRRLQRDGFLELRRLSVPLCSGPCPLTSLSRQGERSGGHLVAAARAAVTAETHPLPLLAPLAVCQSVKSPAACQVRPRPRAVALPAALGGPGRSLPGLTAATMSSFSESALEKKLSELSNSQQSVQTLSLWLIYHRKHAGPIVS
VWHRELRKAKSNRKLTFLYLANDVIQNSKRKGPEFTREFESVLVDAFSHVAREADEGCKKPLERLLNIWQERSVYGGEFIQQLKLSMEDSKSPPPKATEEKKSLKRTFQQIQEEEDDDYPGSYSPQDPSAGPLLTEELIKALQDLENAAS
GDATVRQKIASLPQEVQDVSLLEKITDKEAAERLSKTVDEACLLLAEYNGRLAAELEDRRQLARMLVEYTQNQKDVLSEKEKKLEVDGQVVALLVQNLERLDESVKEEADGVHNTLAIVENMAEFRPEMCTEGAQQGLLQWLLKRLKAKM
PFDANKLYCSEVLAILLQDNDENRELLGELDGIDVLLQQLSVFKRHNPSTAEEQEMMENLFDSLCSCLMLSSNRERFLKGEGLQLMNLMLREKKISRSSALKVLDHAMIGPEGTDNCHKFVDILGLRTIFPLFMKSPRKIKKVGTTEKEH
EEHVCSILASLLRNLRGQQRTRLLNKFTENDSEKVDRLMELHFKYLGAMQVADKKIEGEKHDMVRRGEIIDNDTEEEFYLRRLDAGLFVLQHICYIMAEICNANVPQIRQRVHQILNMRGSSIKIVRHIIKEYAENIGDGRSPEFRENEQ
KRILGLLENF

>RPRD1B_CTNNBL1_ENST00000373433_ENST00000405275_36694658_36393598_5-gene_p.K143N_760_K251N length=760AA
MREVQSGRRLQRDGFLELRRLSVPLCSGPCPLTSLSRQGERSGGHLVAAARAAVTAETHPLPLLAPLAVCQSVKSPAACQVRPRPRAVALPAALGGPGRSLPGLTAATMSSFSESALEKKLSELSNSQQSVQTLSLWLIHHRKHAGPIVS
VWHRELRKAKSNRKLTFLYLANDVIQNSKRKGPEFTREFESVLVDAFSHVAREADEGCKKPLERLLNIWQERSVYGGEFIQQLKLSMEDSKSPPPKATEENKSLKRTFQQIQEEEDDDYPGSYSPQDPSAGPLLTEELIKALQDLENAAS
GDATVRQKIASLPQEVQDVSLLEKITDKEAAERLSKTVDEACLLLAEYNGRLAAELEDRRQLARMLVEYTQNQKDVLSEKEKKLEVDGQVVALLVQNLERLDESVKEEADGVHNTLAIVENMAEFRPEMCTEGAQQGLLQWLLKRLKAKM
PFDANKLYCSEVLAILLQDNDENRELLGELDGIDVLLQQLSVFKRHNPSTAEEQEMMENLFDSLCSCLMLSSNRERFLKGEGLQLMNLMLREKKISRSSALKVLDHAMIGPEGTDNCHKFVDILGLRTIFPLFMKSPRKIKKVGTTEKEH
EEHVCSILASLLRNLRGQQRTRLLNKFTENDSEKVDRLMELHFKYLGAMQVADKKIEGEKHDMVRRGEIIDNDTEEEFYLRRLDAGLFVLQHICYIMAEICNANVPQIRQRVHQILNMRGSSIKIVRHIIKEYAENIGDGRSPEFRENEQ
KRILGLLENF

>RPRD1B_CTNNBL1_ENST00000373433_ENST00000405275_36694658_36393598_5-gene_p.R243C_760_R351C length=760AA
MREVQSGRRLQRDGFLELRRLSVPLCSGPCPLTSLSRQGERSGGHLVAAARAAVTAETHPLPLLAPLAVCQSVKSPAACQVRPRPRAVALPAALGGPGRSLPGLTAATMSSFSESALEKKLSELSNSQQSVQTLSLWLIHHRKHAGPIVS
VWHRELRKAKSNRKLTFLYLANDVIQNSKRKGPEFTREFESVLVDAFSHVAREADEGCKKPLERLLNIWQERSVYGGEFIQQLKLSMEDSKSPPPKATEEKKSLKRTFQQIQEEEDDDYPGSYSPQDPSAGPLLTEELIKALQDLENAAS
GDATVRQKIASLPQEVQDVSLLEKITDKEAAERLSKTVDEACLLLAEYNGCLAAELEDRRQLARMLVEYTQNQKDVLSEKEKKLEVDGQVVALLVQNLERLDESVKEEADGVHNTLAIVENMAEFRPEMCTEGAQQGLLQWLLKRLKAKM
PFDANKLYCSEVLAILLQDNDENRELLGELDGIDVLLQQLSVFKRHNPSTAEEQEMMENLFDSLCSCLMLSSNRERFLKGEGLQLMNLMLREKKISRSSALKVLDHAMIGPEGTDNCHKFVDILGLRTIFPLFMKSPRKIKKVGTTEKEH
EEHVCSILASLLRNLRGQQRTRLLNKFTENDSEKVDRLMELHFKYLGAMQVADKKIEGEKHDMVRRGEIIDNDTEEEFYLRRLDAGLFVLQHICYIMAEICNANVPQIRQRVHQILNMRGSSIKIVRHIIKEYAENIGDGRSPEFRENEQ
KRILGLLENF

>RPRD1B_CTNNBL1_ENST00000373433_ENST00000405275_36694658_36393598_5-gene_p.A88D_760_A196D length=760AA
MREVQSGRRLQRDGFLELRRLSVPLCSGPCPLTSLSRQGERSGGHLVAAARAAVTAETHPLPLLAPLAVCQSVKSPAACQVRPRPRAVALPAALGGPGRSLPGLTAATMSSFSESALEKKLSELSNSQQSVQTLSLWLIHHRKHAGPIVS
VWHRELRKAKSNRKLTFLYLANDVIQNSKRKGPEFTREFESVLVDDFSHVAREADEGCKKPLERLLNIWQERSVYGGEFIQQLKLSMEDSKSPPPKATEEKKSLKRTFQQIQEEEDDDYPGSYSPQDPSAGPLLTEELIKALQDLENAAS
GDATVRQKIASLPQEVQDVSLLEKITDKEAAERLSKTVDEACLLLAEYNGRLAAELEDRRQLARMLVEYTQNQKDVLSEKEKKLEVDGQVVALLVQNLERLDESVKEEADGVHNTLAIVENMAEFRPEMCTEGAQQGLLQWLLKRLKAKM
PFDANKLYCSEVLAILLQDNDENRELLGELDGIDVLLQQLSVFKRHNPSTAEEQEMMENLFDSLCSCLMLSSNRERFLKGEGLQLMNLMLREKKISRSSALKVLDHAMIGPEGTDNCHKFVDILGLRTIFPLFMKSPRKIKKVGTTEKEH
EEHVCSILASLLRNLRGQQRTRLLNKFTENDSEKVDRLMELHFKYLGAMQVADKKIEGEKHDMVRRGEIIDNDTEEEFYLRRLDAGLFVLQHICYIMAEICNANVPQIRQRVHQILNMRGSSIKIVRHIIKEYAENIGDGRSPEFRENEQ
KRILGLLENF

>RPRD1B_CTNNBL1_ENST00000373433_ENST00000405275_36694658_36393598_5-gene_p.R251C_760_R359C length=760AA
MREVQSGRRLQRDGFLELRRLSVPLCSGPCPLTSLSRQGERSGGHLVAAARAAVTAETHPLPLLAPLAVCQSVKSPAACQVRPRPRAVALPAALGGPGRSLPGLTAATMSSFSESALEKKLSELSNSQQSVQTLSLWLIHHRKHAGPIVS
VWHRELRKAKSNRKLTFLYLANDVIQNSKRKGPEFTREFESVLVDAFSHVAREADEGCKKPLERLLNIWQERSVYGGEFIQQLKLSMEDSKSPPPKATEEKKSLKRTFQQIQEEEDDDYPGSYSPQDPSAGPLLTEELIKALQDLENAAS
GDATVRQKIASLPQEVQDVSLLEKITDKEAAERLSKTVDEACLLLAEYNGRLAAELEDCRQLARMLVEYTQNQKDVLSEKEKKLEVDGQVVALLVQNLERLDESVKEEADGVHNTLAIVENMAEFRPEMCTEGAQQGLLQWLLKRLKAKM
PFDANKLYCSEVLAILLQDNDENRELLGELDGIDVLLQQLSVFKRHNPSTAEEQEMMENLFDSLCSCLMLSSNRERFLKGEGLQLMNLMLREKKISRSSALKVLDHAMIGPEGTDNCHKFVDILGLRTIFPLFMKSPRKIKKVGTTEKEH
EEHVCSILASLLRNLRGQQRTRLLNKFTENDSEKVDRLMELHFKYLGAMQVADKKIEGEKHDMVRRGEIIDNDTEEEFYLRRLDAGLFVLQHICYIMAEICNANVPQIRQRVHQILNMRGSSIKIVRHIIKEYAENIGDGRSPEFRENEQ
KRILGLLENF

>RPRD1B_CTNNBL1_ENST00000373433_ENST00000405275_36694658_36393598_5-gene_p.A246V_760_A354V length=760AA
MREVQSGRRLQRDGFLELRRLSVPLCSGPCPLTSLSRQGERSGGHLVAAARAAVTAETHPLPLLAPLAVCQSVKSPAACQVRPRPRAVALPAALGGPGRSLPGLTAATMSSFSESALEKKLSELSNSQQSVQTLSLWLIHHRKHAGPIVS
VWHRELRKAKSNRKLTFLYLANDVIQNSKRKGPEFTREFESVLVDAFSHVAREADEGCKKPLERLLNIWQERSVYGGEFIQQLKLSMEDSKSPPPKATEEKKSLKRTFQQIQEEEDDDYPGSYSPQDPSAGPLLTEELIKALQDLENAAS
GDATVRQKIASLPQEVQDVSLLEKITDKEAAERLSKTVDEACLLLAEYNGRLAVELEDRRQLARMLVEYTQNQKDVLSEKEKKLEVDGQVVALLVQNLERLDESVKEEADGVHNTLAIVENMAEFRPEMCTEGAQQGLLQWLLKRLKAKM
PFDANKLYCSEVLAILLQDNDENRELLGELDGIDVLLQQLSVFKRHNPSTAEEQEMMENLFDSLCSCLMLSSNRERFLKGEGLQLMNLMLREKKISRSSALKVLDHAMIGPEGTDNCHKFVDILGLRTIFPLFMKSPRKIKKVGTTEKEH
EEHVCSILASLLRNLRGQQRTRLLNKFTENDSEKVDRLMELHFKYLGAMQVADKKIEGEKHDMVRRGEIIDNDTEEEFYLRRLDAGLFVLQHICYIMAEICNANVPQIRQRVHQILNMRGSSIKIVRHIIKEYAENIGDGRSPEFRENEQ
KRILGLLENF

>RPRD1B_CTNNBL1_ENST00000373433_ENST00000405275_36694658_36393598_5-gene_p.S203Y_760_S311Y length=760AA
MREVQSGRRLQRDGFLELRRLSVPLCSGPCPLTSLSRQGERSGGHLVAAARAAVTAETHPLPLLAPLAVCQSVKSPAACQVRPRPRAVALPAALGGPGRSLPGLTAATMSSFSESALEKKLSELSNSQQSVQTLSLWLIHHRKHAGPIVS
VWHRELRKAKSNRKLTFLYLANDVIQNSKRKGPEFTREFESVLVDAFSHVAREADEGCKKPLERLLNIWQERSVYGGEFIQQLKLSMEDSKSPPPKATEEKKSLKRTFQQIQEEEDDDYPGSYSPQDPSAGPLLTEELIKALQDLENAAS
GDATVRQKIAYLPQEVQDVSLLEKITDKEAAERLSKTVDEACLLLAEYNGRLAAELEDRRQLARMLVEYTQNQKDVLSEKEKKLEVDGQVVALLVQNLERLDESVKEEADGVHNTLAIVENMAEFRPEMCTEGAQQGLLQWLLKRLKAKM
PFDANKLYCSEVLAILLQDNDENRELLGELDGIDVLLQQLSVFKRHNPSTAEEQEMMENLFDSLCSCLMLSSNRERFLKGEGLQLMNLMLREKKISRSSALKVLDHAMIGPEGTDNCHKFVDILGLRTIFPLFMKSPRKIKKVGTTEKEH
EEHVCSILASLLRNLRGQQRTRLLNKFTENDSEKVDRLMELHFKYLGAMQVADKKIEGEKHDMVRRGEIIDNDTEEEFYLRRLDAGLFVLQHICYIMAEICNANVPQIRQRVHQILNMRGSSIKIVRHIIKEYAENIGDGRSPEFRENEQ
KRILGLLENF

>RPRD1B_CTNNBL1_ENST00000373433_ENST00000405275_36694658_36393598_5-gene_p.D97E_760_D205E length=760AA
MREVQSGRRLQRDGFLELRRLSVPLCSGPCPLTSLSRQGERSGGHLVAAARAAVTAETHPLPLLAPLAVCQSVKSPAACQVRPRPRAVALPAALGGPGRSLPGLTAATMSSFSESALEKKLSELSNSQQSVQTLSLWLIHHRKHAGPIVS
VWHRELRKAKSNRKLTFLYLANDVIQNSKRKGPEFTREFESVLVDAFSHVAREAEEGCKKPLERLLNIWQERSVYGGEFIQQLKLSMEDSKSPPPKATEEKKSLKRTFQQIQEEEDDDYPGSYSPQDPSAGPLLTEELIKALQDLENAAS
GDATVRQKIASLPQEVQDVSLLEKITDKEAAERLSKTVDEACLLLAEYNGRLAAELEDRRQLARMLVEYTQNQKDVLSEKEKKLEVDGQVVALLVQNLERLDESVKEEADGVHNTLAIVENMAEFRPEMCTEGAQQGLLQWLLKRLKAKM
PFDANKLYCSEVLAILLQDNDENRELLGELDGIDVLLQQLSVFKRHNPSTAEEQEMMENLFDSLCSCLMLSSNRERFLKGEGLQLMNLMLREKKISRSSALKVLDHAMIGPEGTDNCHKFVDILGLRTIFPLFMKSPRKIKKVGTTEKEH
EEHVCSILASLLRNLRGQQRTRLLNKFTENDSEKVDRLMELHFKYLGAMQVADKKIEGEKHDMVRRGEIIDNDTEEEFYLRRLDAGLFVLQHICYIMAEICNANVPQIRQRVHQILNMRGSSIKIVRHIIKEYAENIGDGRSPEFRENEQ
KRILGLLENF

>RPRD1B_CTNNBL1_ENST00000373433_ENST00000405275_36694658_36393598_5-gene_p.R198P_760_R306P length=760AA
MREVQSGRRLQRDGFLELRRLSVPLCSGPCPLTSLSRQGERSGGHLVAAARAAVTAETHPLPLLAPLAVCQSVKSPAACQVRPRPRAVALPAALGGPGRSLPGLTAATMSSFSESALEKKLSELSNSQQSVQTLSLWLIHHRKHAGPIVS
VWHRELRKAKSNRKLTFLYLANDVIQNSKRKGPEFTREFESVLVDAFSHVAREADEGCKKPLERLLNIWQERSVYGGEFIQQLKLSMEDSKSPPPKATEEKKSLKRTFQQIQEEEDDDYPGSYSPQDPSAGPLLTEELIKALQDLENAAS
GDATVPQKIASLPQEVQDVSLLEKITDKEAAERLSKTVDEACLLLAEYNGRLAAELEDRRQLARMLVEYTQNQKDVLSEKEKKLEVDGQVVALLVQNLERLDESVKEEADGVHNTLAIVENMAEFRPEMCTEGAQQGLLQWLLKRLKAKM
PFDANKLYCSEVLAILLQDNDENRELLGELDGIDVLLQQLSVFKRHNPSTAEEQEMMENLFDSLCSCLMLSSNRERFLKGEGLQLMNLMLREKKISRSSALKVLDHAMIGPEGTDNCHKFVDILGLRTIFPLFMKSPRKIKKVGTTEKEH
EEHVCSILASLLRNLRGQQRTRLLNKFTENDSEKVDRLMELHFKYLGAMQVADKKIEGEKHDMVRRGEIIDNDTEEEFYLRRLDAGLFVLQHICYIMAEICNANVPQIRQRVHQILNMRGSSIKIVRHIIKEYAENIGDGRSPEFRENEQ
KRILGLLENF

>RPRD1B_CTNNBL1_ENST00000373433_ENST00000405275_36694658_36393598_5-gene_p.Q253H_760_Q361H length=760AA
MREVQSGRRLQRDGFLELRRLSVPLCSGPCPLTSLSRQGERSGGHLVAAARAAVTAETHPLPLLAPLAVCQSVKSPAACQVRPRPRAVALPAALGGPGRSLPGLTAATMSSFSESALEKKLSELSNSQQSVQTLSLWLIHHRKHAGPIVS
VWHRELRKAKSNRKLTFLYLANDVIQNSKRKGPEFTREFESVLVDAFSHVAREADEGCKKPLERLLNIWQERSVYGGEFIQQLKLSMEDSKSPPPKATEEKKSLKRTFQQIQEEEDDDYPGSYSPQDPSAGPLLTEELIKALQDLENAAS
GDATVRQKIASLPQEVQDVSLLEKITDKEAAERLSKTVDEACLLLAEYNGRLAAELEDRRHLARMLVEYTQNQKDVLSEKEKKLEVDGQVVALLVQNLERLDESVKEEADGVHNTLAIVENMAEFRPEMCTEGAQQGLLQWLLKRLKAKM
PFDANKLYCSEVLAILLQDNDENRELLGELDGIDVLLQQLSVFKRHNPSTAEEQEMMENLFDSLCSCLMLSSNRERFLKGEGLQLMNLMLREKKISRSSALKVLDHAMIGPEGTDNCHKFVDILGLRTIFPLFMKSPRKIKKVGTTEKEH
EEHVCSILASLLRNLRGQQRTRLLNKFTENDSEKVDRLMELHFKYLGAMQVADKKIEGEKHDMVRRGEIIDNDTEEEFYLRRLDAGLFVLQHICYIMAEICNANVPQIRQRVHQILNMRGSSIKIVRHIIKEYAENIGDGRSPEFRENEQ
KRILGLLENF

>RPRD1B_CTNNBL1_ENST00000373433_ENST00000405275_36694658_36393598_5-gene_p.Q168R_760_Q276R length=760AA
MREVQSGRRLQRDGFLELRRLSVPLCSGPCPLTSLSRQGERSGGHLVAAARAAVTAETHPLPLLAPLAVCQSVKSPAACQVRPRPRAVALPAALGGPGRSLPGLTAATMSSFSESALEKKLSELSNSQQSVQTLSLWLIHHRKHAGPIVS
VWHRELRKAKSNRKLTFLYLANDVIQNSKRKGPEFTREFESVLVDAFSHVAREADEGCKKPLERLLNIWQERSVYGGEFIQQLKLSMEDSKSPPPKATEEKKSLKRTFQQIQEEEDDDYPGSYSPRDPSAGPLLTEELIKALQDLENAAS
GDATVRQKIASLPQEVQDVSLLEKITDKEAAERLSKTVDEACLLLAEYNGRLAAELEDRRQLARMLVEYTQNQKDVLSEKEKKLEVDGQVVALLVQNLERLDESVKEEADGVHNTLAIVENMAEFRPEMCTEGAQQGLLQWLLKRLKAKM
PFDANKLYCSEVLAILLQDNDENRELLGELDGIDVLLQQLSVFKRHNPSTAEEQEMMENLFDSLCSCLMLSSNRERFLKGEGLQLMNLMLREKKISRSSALKVLDHAMIGPEGTDNCHKFVDILGLRTIFPLFMKSPRKIKKVGTTEKEH
EEHVCSILASLLRNLRGQQRTRLLNKFTENDSEKVDRLMELHFKYLGAMQVADKKIEGEKHDMVRRGEIIDNDTEEEFYLRRLDAGLFVLQHICYIMAEICNANVPQIRQRVHQILNMRGSSIKIVRHIIKEYAENIGDGRSPEFRENEQ
KRILGLLENF

>RPRD1B_CTNNBL1_ENST00000373433_ENST00000405275_36694658_36393598_5-gene_p.N109K_760_N217K length=760AA
MREVQSGRRLQRDGFLELRRLSVPLCSGPCPLTSLSRQGERSGGHLVAAARAAVTAETHPLPLLAPLAVCQSVKSPAACQVRPRPRAVALPAALGGPGRSLPGLTAATMSSFSESALEKKLSELSNSQQSVQTLSLWLIHHRKHAGPIVS
VWHRELRKAKSNRKLTFLYLANDVIQNSKRKGPEFTREFESVLVDAFSHVAREADEGCKKPLERLLKIWQERSVYGGEFIQQLKLSMEDSKSPPPKATEEKKSLKRTFQQIQEEEDDDYPGSYSPQDPSAGPLLTEELIKALQDLENAAS
GDATVRQKIASLPQEVQDVSLLEKITDKEAAERLSKTVDEACLLLAEYNGRLAAELEDRRQLARMLVEYTQNQKDVLSEKEKKLEVDGQVVALLVQNLERLDESVKEEADGVHNTLAIVENMAEFRPEMCTEGAQQGLLQWLLKRLKAKM
PFDANKLYCSEVLAILLQDNDENRELLGELDGIDVLLQQLSVFKRHNPSTAEEQEMMENLFDSLCSCLMLSSNRERFLKGEGLQLMNLMLREKKISRSSALKVLDHAMIGPEGTDNCHKFVDILGLRTIFPLFMKSPRKIKKVGTTEKEH
EEHVCSILASLLRNLRGQQRTRLLNKFTENDSEKVDRLMELHFKYLGAMQVADKKIEGEKHDMVRRGEIIDNDTEEEFYLRRLDAGLFVLQHICYIMAEICNANVPQIRQRVHQILNMRGSSIKIVRHIIKEYAENIGDGRSPEFRENEQ
KRILGLLENF

>RPRD1B_CTNNBL1_ENST00000373433_ENST00000405275_36694658_36393598_5-gene_p.P170T_760_P278T length=760AA
MREVQSGRRLQRDGFLELRRLSVPLCSGPCPLTSLSRQGERSGGHLVAAARAAVTAETHPLPLLAPLAVCQSVKSPAACQVRPRPRAVALPAALGGPGRSLPGLTAATMSSFSESALEKKLSELSNSQQSVQTLSLWLIHHRKHAGPIVS
VWHRELRKAKSNRKLTFLYLANDVIQNSKRKGPEFTREFESVLVDAFSHVAREADEGCKKPLERLLNIWQERSVYGGEFIQQLKLSMEDSKSPPPKATEEKKSLKRTFQQIQEEEDDDYPGSYSPQDTSAGPLLTEELIKALQDLENAAS
GDATVRQKIASLPQEVQDVSLLEKITDKEAAERLSKTVDEACLLLAEYNGRLAAELEDRRQLARMLVEYTQNQKDVLSEKEKKLEVDGQVVALLVQNLERLDESVKEEADGVHNTLAIVENMAEFRPEMCTEGAQQGLLQWLLKRLKAKM
PFDANKLYCSEVLAILLQDNDENRELLGELDGIDVLLQQLSVFKRHNPSTAEEQEMMENLFDSLCSCLMLSSNRERFLKGEGLQLMNLMLREKKISRSSALKVLDHAMIGPEGTDNCHKFVDILGLRTIFPLFMKSPRKIKKVGTTEKEH
EEHVCSILASLLRNLRGQQRTRLLNKFTENDSEKVDRLMELHFKYLGAMQVADKKIEGEKHDMVRRGEIIDNDTEEEFYLRRLDAGLFVLQHICYIMAEICNANVPQIRQRVHQILNMRGSSIKIVRHIIKEYAENIGDGRSPEFRENEQ
KRILGLLENF

>RPRD1B_CTNNBL1_ENST00000373433_ENST00000405275_36694658_36393598_5-gene_p.K216N_760_K324N length=760AA
MREVQSGRRLQRDGFLELRRLSVPLCSGPCPLTSLSRQGERSGGHLVAAARAAVTAETHPLPLLAPLAVCQSVKSPAACQVRPRPRAVALPAALGGPGRSLPGLTAATMSSFSESALEKKLSELSNSQQSVQTLSLWLIHHRKHAGPIVS
VWHRELRKAKSNRKLTFLYLANDVIQNSKRKGPEFTREFESVLVDAFSHVAREADEGCKKPLERLLNIWQERSVYGGEFIQQLKLSMEDSKSPPPKATEEKKSLKRTFQQIQEEEDDDYPGSYSPQDPSAGPLLTEELIKALQDLENAAS
GDATVRQKIASLPQEVQDVSLLENITDKEAAERLSKTVDEACLLLAEYNGRLAAELEDRRQLARMLVEYTQNQKDVLSEKEKKLEVDGQVVALLVQNLERLDESVKEEADGVHNTLAIVENMAEFRPEMCTEGAQQGLLQWLLKRLKAKM
PFDANKLYCSEVLAILLQDNDENRELLGELDGIDVLLQQLSVFKRHNPSTAEEQEMMENLFDSLCSCLMLSSNRERFLKGEGLQLMNLMLREKKISRSSALKVLDHAMIGPEGTDNCHKFVDILGLRTIFPLFMKSPRKIKKVGTTEKEH
EEHVCSILASLLRNLRGQQRTRLLNKFTENDSEKVDRLMELHFKYLGAMQVADKKIEGEKHDMVRRGEIIDNDTEEEFYLRRLDAGLFVLQHICYIMAEICNANVPQIRQRVHQILNMRGSSIKIVRHIIKEYAENIGDGRSPEFRENEQ
KRILGLLENF

>RPRD1B_CTNNBL1_ENST00000373433_ENST00000405275_36694658_36393598_5-gene_p.V211A_760_V319A length=760AA
MREVQSGRRLQRDGFLELRRLSVPLCSGPCPLTSLSRQGERSGGHLVAAARAAVTAETHPLPLLAPLAVCQSVKSPAACQVRPRPRAVALPAALGGPGRSLPGLTAATMSSFSESALEKKLSELSNSQQSVQTLSLWLIHHRKHAGPIVS
VWHRELRKAKSNRKLTFLYLANDVIQNSKRKGPEFTREFESVLVDAFSHVAREADEGCKKPLERLLNIWQERSVYGGEFIQQLKLSMEDSKSPPPKATEEKKSLKRTFQQIQEEEDDDYPGSYSPQDPSAGPLLTEELIKALQDLENAAS
GDATVRQKIASLPQEVQDASLLEKITDKEAAERLSKTVDEACLLLAEYNGRLAAELEDRRQLARMLVEYTQNQKDVLSEKEKKLEVDGQVVALLVQNLERLDESVKEEADGVHNTLAIVENMAEFRPEMCTEGAQQGLLQWLLKRLKAKM
PFDANKLYCSEVLAILLQDNDENRELLGELDGIDVLLQQLSVFKRHNPSTAEEQEMMENLFDSLCSCLMLSSNRERFLKGEGLQLMNLMLREKKISRSSALKVLDHAMIGPEGTDNCHKFVDILGLRTIFPLFMKSPRKIKKVGTTEKEH
EEHVCSILASLLRNLRGQQRTRLLNKFTENDSEKVDRLMELHFKYLGAMQVADKKIEGEKHDMVRRGEIIDNDTEEEFYLRRLDAGLFVLQHICYIMAEICNANVPQIRQRVHQILNMRGSSIKIVRHIIKEYAENIGDGRSPEFRENEQ
KRILGLLENF

>RPRD1B_CTNNBL1_ENST00000373433_ENST00000405275_36694658_36393598_5-gene_p.S19C_760_S127C length=760AA
MREVQSGRRLQRDGFLELRRLSVPLCSGPCPLTSLSRQGERSGGHLVAAARAAVTAETHPLPLLAPLAVCQSVKSPAACQVRPRPRAVALPAALGGPGRSLPGLTAATMSSFSESALEKKLSELSNCQQSVQTLSLWLIHHRKHAGPIVS
VWHRELRKAKSNRKLTFLYLANDVIQNSKRKGPEFTREFESVLVDAFSHVAREADEGCKKPLERLLNIWQERSVYGGEFIQQLKLSMEDSKSPPPKATEEKKSLKRTFQQIQEEEDDDYPGSYSPQDPSAGPLLTEELIKALQDLENAAS
GDATVRQKIASLPQEVQDVSLLEKITDKEAAERLSKTVDEACLLLAEYNGRLAAELEDRRQLARMLVEYTQNQKDVLSEKEKKLEVDGQVVALLVQNLERLDESVKEEADGVHNTLAIVENMAEFRPEMCTEGAQQGLLQWLLKRLKAKM
PFDANKLYCSEVLAILLQDNDENRELLGELDGIDVLLQQLSVFKRHNPSTAEEQEMMENLFDSLCSCLMLSSNRERFLKGEGLQLMNLMLREKKISRSSALKVLDHAMIGPEGTDNCHKFVDILGLRTIFPLFMKSPRKIKKVGTTEKEH
EEHVCSILASLLRNLRGQQRTRLLNKFTENDSEKVDRLMELHFKYLGAMQVADKKIEGEKHDMVRRGEIIDNDTEEEFYLRRLDAGLFVLQHICYIMAEICNANVPQIRQRVHQILNMRGSSIKIVRHIIKEYAENIGDGRSPEFRENEQ
KRILGLLENF

>RPRD1B_CTNNBL1_ENST00000373433_ENST00000405275_36694658_36393598_5-gene_p.A238S_760_A346S length=760AA
MREVQSGRRLQRDGFLELRRLSVPLCSGPCPLTSLSRQGERSGGHLVAAARAAVTAETHPLPLLAPLAVCQSVKSPAACQVRPRPRAVALPAALGGPGRSLPGLTAATMSSFSESALEKKLSELSNSQQSVQTLSLWLIHHRKHAGPIVS
VWHRELRKAKSNRKLTFLYLANDVIQNSKRKGPEFTREFESVLVDAFSHVAREADEGCKKPLERLLNIWQERSVYGGEFIQQLKLSMEDSKSPPPKATEEKKSLKRTFQQIQEEEDDDYPGSYSPQDPSAGPLLTEELIKALQDLENAAS
GDATVRQKIASLPQEVQDVSLLEKITDKEAAERLSKTVDEACLLLSEYNGRLAAELEDRRQLARMLVEYTQNQKDVLSEKEKKLEVDGQVVALLVQNLERLDESVKEEADGVHNTLAIVENMAEFRPEMCTEGAQQGLLQWLLKRLKAKM
PFDANKLYCSEVLAILLQDNDENRELLGELDGIDVLLQQLSVFKRHNPSTAEEQEMMENLFDSLCSCLMLSSNRERFLKGEGLQLMNLMLREKKISRSSALKVLDHAMIGPEGTDNCHKFVDILGLRTIFPLFMKSPRKIKKVGTTEKEH
EEHVCSILASLLRNLRGQQRTRLLNKFTENDSEKVDRLMELHFKYLGAMQVADKKIEGEKHDMVRRGEIIDNDTEEEFYLRRLDAGLFVLQHICYIMAEICNANVPQIRQRVHQILNMRGSSIKIVRHIIKEYAENIGDGRSPEFRENEQ
KRILGLLENF

>RPRD1B_CTNNBL1_ENST00000373433_ENST00000405275_36694658_36393598_5-gene_p.R106I_760_R214I length=760AA
MREVQSGRRLQRDGFLELRRLSVPLCSGPCPLTSLSRQGERSGGHLVAAARAAVTAETHPLPLLAPLAVCQSVKSPAACQVRPRPRAVALPAALGGPGRSLPGLTAATMSSFSESALEKKLSELSNSQQSVQTLSLWLIHHRKHAGPIVS
VWHRELRKAKSNRKLTFLYLANDVIQNSKRKGPEFTREFESVLVDAFSHVAREADEGCKKPLEILLNIWQERSVYGGEFIQQLKLSMEDSKSPPPKATEEKKSLKRTFQQIQEEEDDDYPGSYSPQDPSAGPLLTEELIKALQDLENAAS
GDATVRQKIASLPQEVQDVSLLEKITDKEAAERLSKTVDEACLLLAEYNGRLAAELEDRRQLARMLVEYTQNQKDVLSEKEKKLEVDGQVVALLVQNLERLDESVKEEADGVHNTLAIVENMAEFRPEMCTEGAQQGLLQWLLKRLKAKM
PFDANKLYCSEVLAILLQDNDENRELLGELDGIDVLLQQLSVFKRHNPSTAEEQEMMENLFDSLCSCLMLSSNRERFLKGEGLQLMNLMLREKKISRSSALKVLDHAMIGPEGTDNCHKFVDILGLRTIFPLFMKSPRKIKKVGTTEKEH
EEHVCSILASLLRNLRGQQRTRLLNKFTENDSEKVDRLMELHFKYLGAMQVADKKIEGEKHDMVRRGEIIDNDTEEEFYLRRLDAGLFVLQHICYIMAEICNANVPQIRQRVHQILNMRGSSIKIVRHIIKEYAENIGDGRSPEFRENEQ
KRILGLLENF

>RPRD1B_CTNNBL1_ENST00000373433_ENST00000405275_36694658_36393598_5-gene_p.R243C_760_R351C length=760AA
MREVQSGRRLQRDGFLELRRLSVPLCSGPCPLTSLSRQGERSGGHLVAAARAAVTAETHPLPLLAPLAVCQSVKSPAACQVRPRPRAVALPAALGGPGRSLPGLTAATMSSFSESALEKKLSELSNSQQSVQTLSLWLIHHRKHAGPIVS
VWHRELRKAKSNRKLTFLYLANDVIQNSKRKGPEFTREFESVLVDAFSHVAREADEGCKKPLERLLNIWQERSVYGGEFIQQLKLSMEDSKSPPPKATEEKKSLKRTFQQIQEEEDDDYPGSYSPQDPSAGPLLTEELIKALQDLENAAS
GDATVRQKIASLPQEVQDVSLLEKITDKEAAERLSKTVDEACLLLAEYNGCLAAELEDRRQLARMLVEYTQNQKDVLSEKEKKLEVDGQVVALLVQNLERLDESVKEEADGVHNTLAIVENMAEFRPEMCTEGAQQGLLQWLLKRLKAKM
PFDANKLYCSEVLAILLQDNDENRELLGELDGIDVLLQQLSVFKRHNPSTAEEQEMMENLFDSLCSCLMLSSNRERFLKGEGLQLMNLMLREKKISRSSALKVLDHAMIGPEGTDNCHKFVDILGLRTIFPLFMKSPRKIKKVGTTEKEH
EEHVCSILASLLRNLRGQQRTRLLNKFTENDSEKVDRLMELHFKYLGAMQVADKKIEGEKHDMVRRGEIIDNDTEEEFYLRRLDAGLFVLQHICYIMAEICNANVPQIRQRVHQILNMRGSSIKIVRHIIKEYAENIGDGRSPEFRENEQ
KRILGLLENF

>RPRD1B_CTNNBL1_ENST00000373433_ENST00000405275_36694658_36393598_5-gene_p.H45R_760_H153R length=760AA
MREVQSGRRLQRDGFLELRRLSVPLCSGPCPLTSLSRQGERSGGHLVAAARAAVTAETHPLPLLAPLAVCQSVKSPAACQVRPRPRAVALPAALGGPGRSLPGLTAATMSSFSESALEKKLSELSNSQQSVQTLSLWLIHHRKHAGPIVS
VWRRELRKAKSNRKLTFLYLANDVIQNSKRKGPEFTREFESVLVDAFSHVAREADEGCKKPLERLLNIWQERSVYGGEFIQQLKLSMEDSKSPPPKATEEKKSLKRTFQQIQEEEDDDYPGSYSPQDPSAGPLLTEELIKALQDLENAAS
GDATVRQKIASLPQEVQDVSLLEKITDKEAAERLSKTVDEACLLLAEYNGRLAAELEDRRQLARMLVEYTQNQKDVLSEKEKKLEVDGQVVALLVQNLERLDESVKEEADGVHNTLAIVENMAEFRPEMCTEGAQQGLLQWLLKRLKAKM
PFDANKLYCSEVLAILLQDNDENRELLGELDGIDVLLQQLSVFKRHNPSTAEEQEMMENLFDSLCSCLMLSSNRERFLKGEGLQLMNLMLREKKISRSSALKVLDHAMIGPEGTDNCHKFVDILGLRTIFPLFMKSPRKIKKVGTTEKEH
EEHVCSILASLLRNLRGQQRTRLLNKFTENDSEKVDRLMELHFKYLGAMQVADKKIEGEKHDMVRRGEIIDNDTEEEFYLRRLDAGLFVLQHICYIMAEICNANVPQIRQRVHQILNMRGSSIKIVRHIIKEYAENIGDGRSPEFRENEQ
KRILGLLENF

>RPRD1B_CTNNBL1_ENST00000373433_ENST00000405275_36694658_36393598_5-gene_p.I67M_760_I175M length=760AA
MREVQSGRRLQRDGFLELRRLSVPLCSGPCPLTSLSRQGERSGGHLVAAARAAVTAETHPLPLLAPLAVCQSVKSPAACQVRPRPRAVALPAALGGPGRSLPGLTAATMSSFSESALEKKLSELSNSQQSVQTLSLWLIHHRKHAGPIVS
VWHRELRKAKSNRKLTFLYLANDVMQNSKRKGPEFTREFESVLVDAFSHVAREADEGCKKPLERLLNIWQERSVYGGEFIQQLKLSMEDSKSPPPKATEEKKSLKRTFQQIQEEEDDDYPGSYSPQDPSAGPLLTEELIKALQDLENAAS
GDATVRQKIASLPQEVQDVSLLEKITDKEAAERLSKTVDEACLLLAEYNGRLAAELEDRRQLARMLVEYTQNQKDVLSEKEKKLEVDGQVVALLVQNLERLDESVKEEADGVHNTLAIVENMAEFRPEMCTEGAQQGLLQWLLKRLKAKM
PFDANKLYCSEVLAILLQDNDENRELLGELDGIDVLLQQLSVFKRHNPSTAEEQEMMENLFDSLCSCLMLSSNRERFLKGEGLQLMNLMLREKKISRSSALKVLDHAMIGPEGTDNCHKFVDILGLRTIFPLFMKSPRKIKKVGTTEKEH
EEHVCSILASLLRNLRGQQRTRLLNKFTENDSEKVDRLMELHFKYLGAMQVADKKIEGEKHDMVRRGEIIDNDTEEEFYLRRLDAGLFVLQHICYIMAEICNANVPQIRQRVHQILNMRGSSIKIVRHIIKEYAENIGDGRSPEFRENEQ
KRILGLLENF

>RPRD1B_CTNNBL1_ENST00000373433_ENST00000405275_36694658_36393598_5-gene_p.R243C_760_R351C length=760AA
MREVQSGRRLQRDGFLELRRLSVPLCSGPCPLTSLSRQGERSGGHLVAAARAAVTAETHPLPLLAPLAVCQSVKSPAACQVRPRPRAVALPAALGGPGRSLPGLTAATMSSFSESALEKKLSELSNSQQSVQTLSLWLIHHRKHAGPIVS
VWHRELRKAKSNRKLTFLYLANDVIQNSKRKGPEFTREFESVLVDAFSHVAREADEGCKKPLERLLNIWQERSVYGGEFIQQLKLSMEDSKSPPPKATEEKKSLKRTFQQIQEEEDDDYPGSYSPQDPSAGPLLTEELIKALQDLENAAS
GDATVRQKIASLPQEVQDVSLLEKITDKEAAERLSKTVDEACLLLAEYNGCLAAELEDRRQLARMLVEYTQNQKDVLSEKEKKLEVDGQVVALLVQNLERLDESVKEEADGVHNTLAIVENMAEFRPEMCTEGAQQGLLQWLLKRLKAKM
PFDANKLYCSEVLAILLQDNDENRELLGELDGIDVLLQQLSVFKRHNPSTAEEQEMMENLFDSLCSCLMLSSNRERFLKGEGLQLMNLMLREKKISRSSALKVLDHAMIGPEGTDNCHKFVDILGLRTIFPLFMKSPRKIKKVGTTEKEH
EEHVCSILASLLRNLRGQQRTRLLNKFTENDSEKVDRLMELHFKYLGAMQVADKKIEGEKHDMVRRGEIIDNDTEEEFYLRRLDAGLFVLQHICYIMAEICNANVPQIRQRVHQILNMRGSSIKIVRHIIKEYAENIGDGRSPEFRENEQ
KRILGLLENF

>RPRD1B_CTNNBL1_ENST00000373433_ENST00000405275_36694658_36393598_5-gene_p.P137L_760_P245L length=760AA
MREVQSGRRLQRDGFLELRRLSVPLCSGPCPLTSLSRQGERSGGHLVAAARAAVTAETHPLPLLAPLAVCQSVKSPAACQVRPRPRAVALPAALGGPGRSLPGLTAATMSSFSESALEKKLSELSNSQQSVQTLSLWLIHHRKHAGPIVS
VWHRELRKAKSNRKLTFLYLANDVIQNSKRKGPEFTREFESVLVDAFSHVAREADEGCKKPLERLLNIWQERSVYGGEFIQQLKLSMEDSKSPPLKATEEKKSLKRTFQQIQEEEDDDYPGSYSPQDPSAGPLLTEELIKALQDLENAAS
GDATVRQKIASLPQEVQDVSLLEKITDKEAAERLSKTVDEACLLLAEYNGRLAAELEDRRQLARMLVEYTQNQKDVLSEKEKKLEVDGQVVALLVQNLERLDESVKEEADGVHNTLAIVENMAEFRPEMCTEGAQQGLLQWLLKRLKAKM
PFDANKLYCSEVLAILLQDNDENRELLGELDGIDVLLQQLSVFKRHNPSTAEEQEMMENLFDSLCSCLMLSSNRERFLKGEGLQLMNLMLREKKISRSSALKVLDHAMIGPEGTDNCHKFVDILGLRTIFPLFMKSPRKIKKVGTTEKEH
EEHVCSILASLLRNLRGQQRTRLLNKFTENDSEKVDRLMELHFKYLGAMQVADKKIEGEKHDMVRRGEIIDNDTEEEFYLRRLDAGLFVLQHICYIMAEICNANVPQIRQRVHQILNMRGSSIKIVRHIIKEYAENIGDGRSPEFRENEQ
KRILGLLENF

>RPRD1B_CTNNBL1_ENST00000373433_ENST00000405275_36694658_36393598_5-gene_p.S17C_760_S125C length=760AA
MREVQSGRRLQRDGFLELRRLSVPLCSGPCPLTSLSRQGERSGGHLVAAARAAVTAETHPLPLLAPLAVCQSVKSPAACQVRPRPRAVALPAALGGPGRSLPGLTAATMSSFSESALEKKLSELCNSQQSVQTLSLWLIHHRKHAGPIVS
VWHRELRKAKSNRKLTFLYLANDVIQNSKRKGPEFTREFESVLVDAFSHVAREADEGCKKPLERLLNIWQERSVYGGEFIQQLKLSMEDSKSPPPKATEEKKSLKRTFQQIQEEEDDDYPGSYSPQDPSAGPLLTEELIKALQDLENAAS
GDATVRQKIASLPQEVQDVSLLEKITDKEAAERLSKTVDEACLLLAEYNGRLAAELEDRRQLARMLVEYTQNQKDVLSEKEKKLEVDGQVVALLVQNLERLDESVKEEADGVHNTLAIVENMAEFRPEMCTEGAQQGLLQWLLKRLKAKM
PFDANKLYCSEVLAILLQDNDENRELLGELDGIDVLLQQLSVFKRHNPSTAEEQEMMENLFDSLCSCLMLSSNRERFLKGEGLQLMNLMLREKKISRSSALKVLDHAMIGPEGTDNCHKFVDILGLRTIFPLFMKSPRKIKKVGTTEKEH
EEHVCSILASLLRNLRGQQRTRLLNKFTENDSEKVDRLMELHFKYLGAMQVADKKIEGEKHDMVRRGEIIDNDTEEEFYLRRLDAGLFVLQHICYIMAEICNANVPQIRQRVHQILNMRGSSIKIVRHIIKEYAENIGDGRSPEFRENEQ
KRILGLLENF

>RPRD1B_CTNNBL1_ENST00000373433_ENST00000405275_36694658_36393598_5-gene_p.P75S_760_P183S length=760AA
MREVQSGRRLQRDGFLELRRLSVPLCSGPCPLTSLSRQGERSGGHLVAAARAAVTAETHPLPLLAPLAVCQSVKSPAACQVRPRPRAVALPAALGGPGRSLPGLTAATMSSFSESALEKKLSELSNSQQSVQTLSLWLIHHRKHAGPIVS
VWHRELRKAKSNRKLTFLYLANDVIQNSKRKGSEFTREFESVLVDAFSHVAREADEGCKKPLERLLNIWQERSVYGGEFIQQLKLSMEDSKSPPPKATEEKKSLKRTFQQIQEEEDDDYPGSYSPQDPSAGPLLTEELIKALQDLENAAS
GDATVRQKIASLPQEVQDVSLLEKITDKEAAERLSKTVDEACLLLAEYNGRLAAELEDRRQLARMLVEYTQNQKDVLSEKEKKLEVDGQVVALLVQNLERLDESVKEEADGVHNTLAIVENMAEFRPEMCTEGAQQGLLQWLLKRLKAKM
PFDANKLYCSEVLAILLQDNDENRELLGELDGIDVLLQQLSVFKRHNPSTAEEQEMMENLFDSLCSCLMLSSNRERFLKGEGLQLMNLMLREKKISRSSALKVLDHAMIGPEGTDNCHKFVDILGLRTIFPLFMKSPRKIKKVGTTEKEH
EEHVCSILASLLRNLRGQQRTRLLNKFTENDSEKVDRLMELHFKYLGAMQVADKKIEGEKHDMVRRGEIIDNDTEEEFYLRRLDAGLFVLQHICYIMAEICNANVPQIRQRVHQILNMRGSSIKIVRHIIKEYAENIGDGRSPEFRENEQ
KRILGLLENF

>RPRD1B_CTNNBL1_ENST00000373433_ENST00000405275_36694658_36393598_5-gene_p.E98K_760_E206K length=760AA
MREVQSGRRLQRDGFLELRRLSVPLCSGPCPLTSLSRQGERSGGHLVAAARAAVTAETHPLPLLAPLAVCQSVKSPAACQVRPRPRAVALPAALGGPGRSLPGLTAATMSSFSESALEKKLSELSNSQQSVQTLSLWLIHHRKHAGPIVS
VWHRELRKAKSNRKLTFLYLANDVIQNSKRKGPEFTREFESVLVDAFSHVAREADKGCKKPLERLLNIWQERSVYGGEFIQQLKLSMEDSKSPPPKATEEKKSLKRTFQQIQEEEDDDYPGSYSPQDPSAGPLLTEELIKALQDLENAAS
GDATVRQKIASLPQEVQDVSLLEKITDKEAAERLSKTVDEACLLLAEYNGRLAAELEDRRQLARMLVEYTQNQKDVLSEKEKKLEVDGQVVALLVQNLERLDESVKEEADGVHNTLAIVENMAEFRPEMCTEGAQQGLLQWLLKRLKAKM
PFDANKLYCSEVLAILLQDNDENRELLGELDGIDVLLQQLSVFKRHNPSTAEEQEMMENLFDSLCSCLMLSSNRERFLKGEGLQLMNLMLREKKISRSSALKVLDHAMIGPEGTDNCHKFVDILGLRTIFPLFMKSPRKIKKVGTTEKEH
EEHVCSILASLLRNLRGQQRTRLLNKFTENDSEKVDRLMELHFKYLGAMQVADKKIEGEKHDMVRRGEIIDNDTEEEFYLRRLDAGLFVLQHICYIMAEICNANVPQIRQRVHQILNMRGSSIKIVRHIIKEYAENIGDGRSPEFRENEQ
KRILGLLENF



Fusion Protein IDSample IDMutated PartnerAAchange in WTSeq. LengthAAchange in Fusion
ENST00000373433_ENST00000373473_36694658_36393598TCGA-02-0047-01A5-genep.S128P760S236P
ENST00000373433_ENST00000373473_36694658_36393598TCGA-17-Z022-01A5-genep.G119C760G227C
ENST00000373433_ENST00000373473_36694658_36393598TCGA-60-2704-01A5-genep.R251H760R359H
ENST00000373433_ENST00000373473_36694658_36393598TCGA-67-3771-01A5-genep.R243L760R351L
ENST00000373433_ENST00000373473_36694658_36393598TCGA-A8-A09R-01A5-genep.H32Y760H140Y
ENST00000373433_ENST00000373473_36694658_36393598TCGA-AA-A00N-01A5-genep.K143N760K251N
ENST00000373433_ENST00000373473_36694658_36393598TCGA-AJ-A5DW-01A5-genep.R243C760R351C
ENST00000373433_ENST00000373473_36694658_36393598TCGA-AP-A0LM-01A5-genep.A88D760A196D
ENST00000373433_ENST00000373473_36694658_36393598TCGA-AX-A0J1-01A5-genep.R251C760R359C
ENST00000373433_ENST00000373473_36694658_36393598TCGA-B5-A0JZ-01A5-genep.A246V760A354V
ENST00000373433_ENST00000373473_36694658_36393598TCGA-B5-A1MR-01A5-genep.S203Y760S311Y
ENST00000373433_ENST00000373473_36694658_36393598TCGA-B8-A8YJ-01A5-genep.D97E760D205E
ENST00000373433_ENST00000373473_36694658_36393598TCGA-BC-A10W-01A5-genep.R198P760R306P
ENST00000373433_ENST00000373473_36694658_36393598TCGA-BS-A0VI-01A5-genep.Q253H760Q361H
ENST00000373433_ENST00000373473_36694658_36393598TCGA-CG-4305-01A5-genep.Q168R760Q276R
ENST00000373433_ENST00000373473_36694658_36393598TCGA-D1-A15X-01A5-genep.N109K760N217K
ENST00000373433_ENST00000373473_36694658_36393598TCGA-D1-A16N-01A5-genep.P170T760P278T
ENST00000373433_ENST00000373473_36694658_36393598TCGA-D9-A6EC-06A5-genep.K216N760K324N
ENST00000373433_ENST00000373473_36694658_36393598TCGA-DI-A1BU-01A5-genep.V211A760V319A
ENST00000373433_ENST00000373473_36694658_36393598TCGA-DK-A2I4-01A5-genep.S19C760S127C
ENST00000373433_ENST00000373473_36694658_36393598TCGA-DX-A6YV-01A5-genep.A238S760A346S
ENST00000373433_ENST00000373473_36694658_36393598TCGA-EE-A20F-06A5-genep.R106I760R214I
ENST00000373433_ENST00000373473_36694658_36393598TCGA-EO-A22U-01A5-genep.R243C760R351C
ENST00000373433_ENST00000373473_36694658_36393598TCGA-EO-A3B0-01A5-genep.H45R760H153R
ENST00000373433_ENST00000373473_36694658_36393598TCGA-EW-A1IW-01A5-genep.I67M760I175M
ENST00000373433_ENST00000373473_36694658_36393598TCGA-FI-A2D0-01A5-genep.R243C760R351C
ENST00000373433_ENST00000373473_36694658_36393598TCGA-FW-A3R5-06A5-genep.P137L760P245L
ENST00000373433_ENST00000373473_36694658_36393598TCGA-G4-6293-01A5-genep.S17C760S125C
ENST00000373433_ENST00000373473_36694658_36393598TCGA-IN-A6RR-01A5-genep.P75S760P183S
ENST00000373433_ENST00000373473_36694658_36393598TCGA-LT-A8JT-01A5-genep.E98K760E206K
ENST00000373433_ENST00000405275_36694658_36393598TCGA-02-0047-01A5-genep.S128P760S236P
ENST00000373433_ENST00000405275_36694658_36393598TCGA-17-Z022-01A5-genep.G119C760G227C
ENST00000373433_ENST00000405275_36694658_36393598TCGA-60-2704-01A5-genep.R251H760R359H
ENST00000373433_ENST00000405275_36694658_36393598TCGA-67-3771-01A5-genep.R243L760R351L
ENST00000373433_ENST00000405275_36694658_36393598TCGA-A8-A09R-01A5-genep.H32Y760H140Y
ENST00000373433_ENST00000405275_36694658_36393598TCGA-AA-A00N-01A5-genep.K143N760K251N
ENST00000373433_ENST00000405275_36694658_36393598TCGA-AJ-A5DW-01A5-genep.R243C760R351C
ENST00000373433_ENST00000405275_36694658_36393598TCGA-AP-A0LM-01A5-genep.A88D760A196D
ENST00000373433_ENST00000405275_36694658_36393598TCGA-AX-A0J1-01A5-genep.R251C760R359C
ENST00000373433_ENST00000405275_36694658_36393598TCGA-B5-A0JZ-01A5-genep.A246V760A354V
ENST00000373433_ENST00000405275_36694658_36393598TCGA-B5-A1MR-01A5-genep.S203Y760S311Y
ENST00000373433_ENST00000405275_36694658_36393598TCGA-B8-A8YJ-01A5-genep.D97E760D205E
ENST00000373433_ENST00000405275_36694658_36393598TCGA-BC-A10W-01A5-genep.R198P760R306P
ENST00000373433_ENST00000405275_36694658_36393598TCGA-BS-A0VI-01A5-genep.Q253H760Q361H
ENST00000373433_ENST00000405275_36694658_36393598TCGA-CG-4305-01A5-genep.Q168R760Q276R
ENST00000373433_ENST00000405275_36694658_36393598TCGA-D1-A15X-01A5-genep.N109K760N217K
ENST00000373433_ENST00000405275_36694658_36393598TCGA-D1-A16N-01A5-genep.P170T760P278T
ENST00000373433_ENST00000405275_36694658_36393598TCGA-D9-A6EC-06A5-genep.K216N760K324N
ENST00000373433_ENST00000405275_36694658_36393598TCGA-DI-A1BU-01A5-genep.V211A760V319A
ENST00000373433_ENST00000405275_36694658_36393598TCGA-DK-A2I4-01A5-genep.S19C760S127C
ENST00000373433_ENST00000405275_36694658_36393598TCGA-DX-A6YV-01A5-genep.A238S760A346S
ENST00000373433_ENST00000405275_36694658_36393598TCGA-EE-A20F-06A5-genep.R106I760R214I
ENST00000373433_ENST00000405275_36694658_36393598TCGA-EO-A22U-01A5-genep.R243C760R351C
ENST00000373433_ENST00000405275_36694658_36393598TCGA-EO-A3B0-01A5-genep.H45R760H153R
ENST00000373433_ENST00000405275_36694658_36393598TCGA-EW-A1IW-01A5-genep.I67M760I175M
ENST00000373433_ENST00000405275_36694658_36393598TCGA-FI-A2D0-01A5-genep.R243C760R351C
ENST00000373433_ENST00000405275_36694658_36393598TCGA-FW-A3R5-06A5-genep.P137L760P245L
ENST00000373433_ENST00000405275_36694658_36393598TCGA-G4-6293-01A5-genep.S17C760S125C
ENST00000373433_ENST00000405275_36694658_36393598TCGA-IN-A6RR-01A5-genep.P75S760P183S
ENST00000373433_ENST00000405275_36694658_36393598TCGA-LT-A8JT-01A5-genep.E98K760E206K

check button CCLE All Mutated Fusion Protein Sequences


Fusion Protein IDSample IDMutated PartnerAAchange in WTSeq. LengthAAchange in Fusion

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Fusion Gene Exprssed Samples for RPRD1B_CTNNBL1


check buttonRNA-seq based fusion gene expressed samples.
SourceStudyDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDBLUADTCGA-44-5644-01ARPRD1B

chr20

36694658-CTNNBL1

chr20

0

+
ChimerDBLUADTCGA-44-5644-01ARPRD1B

chr20

36694658+CTNNBL1

chr20

36694658

+
TCGAfusionPortalLUADTCGA-44-5644-01ARPRD1B

chr20

36694658+CTNNBL1

chr20

36393599

+
WashULUADTCGA-44-5644-01ARPRD1B

chr20

36694658+CTNNBL1

chr20

36393599

+
cBioPortalLUAD_TCGA_PAN_CAN_ATLAS_2018LUADTCGA-44-5644-01RPRD1B

chr20

38066256CTNNBL1

chr20

37765197


check buttonDNA-seq based fusion gene expressed samples.
SourceStudyDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrandSV type


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Related Drugs for RPRD1B_CTNNBL1


check button PubMed Abstract Search With ['A-B' AND 'drug'], ['A::B' AND 'drug']
* For more details on the Studied, Reported, Approved Drugs targeting this fusion gene, Go to FusionPub.
PMIDFusion Gene NameDrugStudy Title

check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status