Home

Download

Statistics

Examples

About

Contact

	Fusion Gene Summary
	Fusion Gene Breakpoints
	Tumorigenic MoA (Mechanism of Action) Scenarios of Fusion Geness
	Fusion Genomic Features
	Fusion Gene ORF Annotations
	Fusion Protein Retained/Non-Retained Functional Features
	Fusion Transcript Sequences
	Fusion Protein Sequences
	Personalized Fusion Protein Sequences
	Fusion Gene Expressed Samples
	Related Drugs

Fusion gene:RFC1_EHBP1 (FusionGDB2 ID:HG5981TG23301)

Fusion Gene Summary for RFC1_EHBP1

Fusion gene summary

Fusion gene information	Fusion gene name: RFC1_EHBP1
	Fusion gene ID: hg5981tg23301
		Hgene	Tgene
	Gene symbol	RFC1	EHBP1
	Gene ID	5981	23301
	Gene name	replication factor C subunit 1	EH domain binding protein 1
	Synonyms	A1\|CANVAS\|MHCBFB\|PO-GA\|RECC1\|RFC\|RFC140	HPC12\|NACSIN
	Cytomap	4p14	2p15
	Type of gene	protein-coding	protein-coding
	Description	replication factor C subunit 1A1 140 kDa subunitDNA-binding protein PO-GAMHC binding factor, betaRF-C 140 kDa subunitactivator 1 140 kDa subunitactivator 1 large subunitactivator 1 subunit 1replication factor C (activator 1) 1, 145kDareplication	EH domain-binding protein 1NPF calponin-like proteintestis tissue sperm-binding protein Li 50e
	Modification date	20240411	20240403
	UniProtAcc	.	.
	Ensembl transtripts involved in fusion gene	ENST00000349703, ENST00000381897, ENST00000418436,
Fusion gene scores	* DoF score	* DoF score (Degree of Frequency) = # partners X # break points X # disease types 12 X 12 X 12=1728	* DoF score (Degree of Frequency) = # partners X # break points X # disease types 5 X 23 X 5=575
	# samples	15	18
	** MAII score	** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score10) log2(15/172810)=-3.52606881166759 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score10) log2(18/57510)=-1.67556504950206 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: RFC1 [Title/Abstract] AND EHBP1 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	RFC1(39343964)-EHBP1(63169852), # samples:1

Top

Fusion Gene Breakpoints for RFC1_EHBP1

RNA-seq based exon junction arranged fusion gene breakpoints from 8 resources (TCGA, CCLE, cBioPortal, GenBank, ChimerDB, ChimerKB, ChildHoodFusions, and GTEx). For the expressed sample information, go to Fusion Gene Sample section.

Hgene	Hchr	Hbp	Tgene	Tchr	Tbp
RFC1	chr4	39343964	EHBP1	chr2	39343964
RFC1	chr4	39343965	EHBP1	chr2	63169853
RFC1	chr4	39342345	EHBP1	chr2	62942718

DNA-seq based exon junction arranged fusion gene breakpoints from dbVar. For the expressed sample information, go to Fusion Gene Sample section.

Hgene

Hchr

Hbp

Tgene

Tchr

Tbp

SV type

Top

Tumorigenic MoA (Mechanism of Action) Scenarios of Fusion Genes for RFC1_EHBP1

To generate these tumorigenic scenario annotations, we implemented a deduction-first, retrieval-later computational framework. The pipeline first applies rule-guided reasoning across ten core mechanistic categories (M1–M10) derived from fusion gene biology to infer candidate mechanisms, tumorigenic scenarios, targeting points, and targeting backgrounds. To ensure empirical accountability, a governed Python workflow retrieves literature candidates via NCBI E-utilities and Europe PMC using tiered searches. Using JSON Schema-constrained LLM evidence judges (GPT-5.6 Luna and Terra), retrieved articles are evaluated for specificity and confidence without de novo PMID generation. This produces two distinct versions: a strict version restricted to high- or medium-confidence fusion-specific evidence, and an extended version incorporating broader gene-, pathway-, and contextual evidence.

* We have 10 tumorigenic mechanism categories of fusion genes as shown below.

Constitutively Active Kinases, Catalytic Domain Dysregulation, & Transmembrane Ligand Fusions	Aberrant Chimeric Transcription Factor / Fusion Transcription Factor Activity	Epigenetic Reprogramming / Histone Modifier Dysregulation	Chromatin Remodeling Dysregulation	Condensate-Driven Transcriptional Rewiring / LLP	Promoter / Enhancer Hijacking	Dominant-Negative Antagonism	Cell Cycle / Checkpoint Bypass / RNA Processing Dysregulation	Subcellular Mislocalization / Spatial Dysregulation	Nuclear Body / Sub-organellar Architecture Disruption & Differentiation Blockade

* Strict version: Restricted to high- or medium-confidence fusion-specific evidence.

Fusion Gene Name	Mechanism Category	Mechanism PubMed	Tumorigenic Scenarios	Tumorigenic Scenario PubMed	Targeting Points	Targeting PubMed	Mechanism Background	Mechanism Background PubMed
RFC1-EHBP1	Cell Cycle / Checkpoint Bypass / RNA Processing Dysregulation M8		RFC1 clamp loader couples to EH domain-binding protein 1, coordinating DNA replication licensing with endocytic receptor recycling and actin-dependent trafficking.		Endocytosis modulators; ATR/Chk1 inhibitors; PARP blockers		Genomically unstable solid tumors

* Extended version: Includes all strict-level fusion evidence plus broader gene-, pathway-, and low-confidence contextual evidence.

Fusion Gene Name	Mechanism Category	Mechanism PubMed	Tumorigenic Scenarios	Tumorigenic Scenario PubMed	Targeting Points	Targeting PubMed	Mechanism Background	Mechanism Background PubMed
RFC1-EHBP1	Cell Cycle / Checkpoint Bypass / RNA Processing Dysregulation		RFC1 clamp loader couples to EH domain-binding protein 1, coordinating DNA replication licensing with endocytic receptor recycling and actin-dependent trafficking.		Endocytosis modulators; ATR/Chk1 inhibitors; PARP blockers		Genomically unstable solid tumors

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	RFC1	GO:0006261	DNA-templated DNA replication	9488738

Top

Fusion Genomic Features for RFC1_EHBP1

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence) of In-frame fusion genes. FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
RFC1	chr4	39343964	-	EHBP1	chr2	63169852	+	2.63e-05	1.00e+00

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence) of 5UTR-3CSD fusion genes (N-truncated cases).

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
RFC1	chr4	39343964	-	EHBP1	chr2	63169852	+	2.63e-05	1.00e+00

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence) of 5CDS-3UTR fusion genes (C-truncated cases).

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of six genomic regulatory feature tracks across a ±5 kb window centered on the fusion breakpoints. We input the breakpoint sequences into AlphaGenome and obtained predicted genome tracks at single-base-pair resolution for each modality by running a single forward pass over the reference sequence. Specifically, for each breakpoint, AlphaGenome processed and returned predicted track data across diverse modalities, which were then averaged across all tracks within each output type and visualized across the ±5 kb window. The left panel shows the 5'-gene breakpoint ±5 kb area, and the right panel shows the 3'-gene breakpoint area, with tracks grouped by category: chromatin accessibility (DNase-seq, ATAC-seq), active transcription (RNA-seq, CAGE), and chromatin binding (ChIP-Histone, ChIP-TF).

Top

Fusion Gene ORF Annotations for RFC1_EHBP1

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5UTR-3CDS	ENST00000418436	ENST00000263991	RFC1	chr4	39343964	-	EHBP1	chr2	63169852	+
5UTR-3CDS	ENST00000418436	ENST00000354487	RFC1	chr4	39343964	-	EHBP1	chr2	63169852	+
5UTR-3CDS	ENST00000418436	ENST00000405015	RFC1	chr4	39343964	-	EHBP1	chr2	63169852	+
5UTR-3CDS	ENST00000418436	ENST00000405289	RFC1	chr4	39343964	-	EHBP1	chr2	63169852	+
5UTR-3CDS	ENST00000418436	ENST00000431489	RFC1	chr4	39343964	-	EHBP1	chr2	63169852	+
Frame-shift	ENST00000349703	ENST00000263991	RFC1	chr4	39343964	-	EHBP1	chr2	63169852	+
Frame-shift	ENST00000349703	ENST00000354487	RFC1	chr4	39343964	-	EHBP1	chr2	63169852	+
Frame-shift	ENST00000349703	ENST00000405015	RFC1	chr4	39343964	-	EHBP1	chr2	63169852	+
Frame-shift	ENST00000349703	ENST00000405289	RFC1	chr4	39343964	-	EHBP1	chr2	63169852	+
Frame-shift	ENST00000349703	ENST00000431489	RFC1	chr4	39343964	-	EHBP1	chr2	63169852	+
Frame-shift	ENST00000381897	ENST00000263991	RFC1	chr4	39343964	-	EHBP1	chr2	63169852	+
Frame-shift	ENST00000381897	ENST00000354487	RFC1	chr4	39343964	-	EHBP1	chr2	63169852	+
Frame-shift	ENST00000381897	ENST00000405015	RFC1	chr4	39343964	-	EHBP1	chr2	63169852	+
Frame-shift	ENST00000381897	ENST00000405289	RFC1	chr4	39343964	-	EHBP1	chr2	63169852	+
Frame-shift	ENST00000381897	ENST00000431489	RFC1	chr4	39343964	-	EHBP1	chr2	63169852	+

ORFfinder Result Based On The Fusion Transcript Sequences of the In-frame Fusion Genes.

Henst

Tenst

Hgene

Hchr

Hbp

Tgene

Tchr

Tbp

Seq length
(transcript)

Seq length
(peptide)

ORFfinder Result Based On The Fusion Transcript Sequences of the 5UTR-3CDS Fusion Genes for N-Truncated Protein Search.

Henst	Tenst	Hgene	Hchr	Hbp	Tgene	Tchr	Tbp	Seq length (transcript)	Seq length (peptide)
ENST00000418436	ENST00000263991	RFC1	chr4	39343964	EHBP1	chr2	63169852	0	93
ENST00000418436	ENST00000354487	RFC1	chr4	39343964	EHBP1	chr2	63169852	0	74
ENST00000418436	ENST00000405015	RFC1	chr4	39343964	EHBP1	chr2	63169852	0	82
ENST00000418436	ENST00000405289	RFC1	chr4	39343964	EHBP1	chr2	63169852	0	757
ENST00000418436	ENST00000431489	RFC1	chr4	39343964	EHBP1	chr2	63169852	0	793

ORFfinder Result Based On The Fusion Transcript Sequences of the 5CDS-3UTR Fusion Genes for C-Truncated Protein Search.

Henst

Tenst

Hgene

Hchr

Hbp

Tgene

Tchr

Tbp

Seq length
(transcript)

Seq length
(peptide)

DeepORF Prediction of The Coding Potential Based on The Fusion Transcript Sequence of In-frame Fusion Genes. DeepORF is a Coding Potential Classifier Based on Convolutional Neural Network by Comparing the Real Ribo-seq Data. If the No-coding Score < 0.5 and Coding Score > 0.5, Then The In-frame Fusion Transcript is Predicted as Being Likely Translated.

Henst

Tenst

Hgene

Hchr

Hbp

Tgene

Tchr

Tbp

No-coding score

Coding score

DeepORF Prediction of The Coding Potential Based on The Fusion Transcript Sequence of 5UTR-3CDS Fusion Genes (Potential N-Truncated Proteins).

Henst	Tenst	Hgene	Hchr	Hbp	Tgene	Tchr	Tbp	No-coding score	Coding score
ENST00000418436	ENST00000263991	RFC1	chr4	39343964	EHBP1	chr2	63169852	0.00e+00	4.24e-05
ENST00000418436	ENST00000354487	RFC1	chr4	39343964	EHBP1	chr2	63169852	0.00e+00	4.23e-05
ENST00000418436	ENST00000405015	RFC1	chr4	39343964	EHBP1	chr2	63169852	0.00e+00	5.79e-05
ENST00000418436	ENST00000405289	RFC1	chr4	39343964	EHBP1	chr2	63169852	0.00e+00	3.38e-05
ENST00000418436	ENST00000431489	RFC1	chr4	39343964	EHBP1	chr2	63169852	0.00e+00	6.49e-05

DeepORF Prediction of The Coding Potential Based on The Fusion Transcript Sequence of 5CDS-3UTR Fusion Genes (Potential C-Truncated Proteins).

Henst

Tenst

Hgene

Hchr

Hbp

Tgene

Tchr

Tbp

No-coding score

Coding score

Top

Fusion Protein Retained/Non-Retained Functional Features for RFC1_EHBP1

Protein Level Annotation from FGviewer
* Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at download page. Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features (visualization across fusion protein length).

No matching images found for ${hg}_${tg}.

- In-frame and retained protein feature among the 13 regional features (texts).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- Retained PPIs in in-frame fusion.

Partner

Hgene

Hbp

Tgene

Tbp

ENST

UniProt

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Hgene

Hbp

Tgene

Tbp

ENST

UniProt

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Fusion Transcript Sequence for RFC1_EHBP1

In-frame Fusion Transcript Sequences.

N-Truncated Transcript (5UTR-3CDS) Sequences

>RFC1_EHBP1_ENST00000418436_ENST00000263991_39343964_63169852 length=3393nt 
 Breakpoint=0nt
CCAAGCCCTATACCAAGTCCTGTTTTGGGGCGAAAGCCAAATGCTAGTCAGTCTTTGCTTGTATGGTGTAAAGAAGTTACAAAGAACTACCGAGGAGTAAAAATCACCAATTTTACTACATCGTGGAGAAATGGTTTATCTTTTTGTGCA
ATATTACACCACTTTAGACCAGATTTAATTGACTACAAGTCTCTGAATCCTCAAGATATTAAAGAGAACAACAAAAAGGCATACGATGGATTTGCCAGCATAGGAATTTCCCGATTATTGGAACCTTCTGATATGGTATTATTAGCAATT
CCTGATAAACTGACTGTTATGACTTATCTCTATCAAATAAGGGCACATTTCAGTGGCCAAGAACTAAATGTCGTTCAGATAGAGGAAAACAGCAGTAAAAGCACATATAAAGTTGGAAACTATGAAACAGATACAAACAGTTCTGTTGAT
CAAGAAAAATTCTATGCAGAGCTTAGTGATCTGAAGCGGGAGCCTGAACTACAACAGCCTATCAGCGGAGCAGTAGACTTCTTATCACAGGATGACTCTGTATTTGTAAATGATAGCGGGGTTGGAGAGTCAGAAAGTGAGCATCAAACT
CCTGATGATCACCTTAGTCCAAGCACAGCCTCCCCTTACTGTCGCAGGACTAAAAGTGACACAGAACCCCAGAAGTCTCAGCAGAGCTCTGGAAGGACTTCAGGATCTGATGACCCTGGAATATGTTCCAATACAGATTCAACCCAAGCA
CAGGTTTTGTTAGGCAAAAAGAGACTATTGAAAGCTGAGACTTTAGAATTGAGTGACTTATATGTTAGTGATAAGAAGAAGGATATGTCTCCACCCTTTATTTGTGAGGAGACAGATGAACAAAAGCTTCAAACTCTAGACATCGGTAGT
AACTTGGAGAAAGAAAAATTAGAGAATTCCAGATCCTTAGAATGCAGATCAGATCCAGAATCTCCTATCAAAAAAACAAGTTTATCTCCTACTTCTAAACTTGGATACTCATATAGTAGAGATCTAGACCTTGCTAAGAAAAAACATGCT
TCCCTGAGGCAGACGGAGTCTGATCCAGATGCTGATAGAACCACTTTAAATCATGCAGATCATTCATCAAAAATAGTCCAGCATCGATTGTTATCTAGACAAGAAGAACTTAAGGAAAGAGCAAGAGTTCTGCTTGAGCAAGCAAGAAGA
GATGCAGCCTTAAAGGCGGGGAATAAGCACAATACCAACACAGCCACCCCATTCTGCAACAGGCAGCTAAGTGATCAGCAAGATGAAGAGCGACGTCGGCAGCTGAGAGAGAGAGCTCGTCAGCTAATAGCAGAAGCTCGATCTGGAGTG
AAGATGTCAGAACTTCCCAGCTATGGTGAAATGGCTGCAGAAAAGTTGAAAGAAAGGTCAAAGGCATCTGGAGATGAAAATGATAATATTGAGATAGATACTAACGAGGAGATCCCTGAAGGCTTTGTTGTAGGAGGTGGAGATGAACTT
ACTAACTTAGAAAATGACCTTGATACTCCCGAACAAAACAGTAAGTTGGTGGACTTGAAGCTGAAGAAGCTCCTAGAAGTTCAGCCACAGGTGGCAAATTCACCCTCCAGTGCTGCCCAGAAAGCTGTAACTGAGAGCTCAGAGCAGGAC
ATGAAAAGTGGCACAGAAGATCTCCGGACTGAACGATTACAAAAAACAACAGAACGTTTTAGAAATCCTGTTGTGTTCAGCAAAGATTCTACAGTCAGAAAAACTCAACTTCAGTCTTTCAGCCAATATATTGAGAATAGACCAGAGATG
AAAAGGCAGAGATCAATACAGGAAGATACAAAGAAAGGAAATGAGGAGAAGGCAGCGATAACTGAAACTCAGAGGAAGCCATCAGAAGATGAAGTGCTTAATAAAGGGTTCAAAGACACCAGTCAGTATGTAGTAGGAGAATTGGCAGCA
CTAGAGAATGAGCAAAAGCAAATTGACACCCGTGCCGCGCTGGTGGAGAAGCGCCTTCGCTATCTCATGGACACAGGAAGGAACACAGAAGAAGAAGAAGCTATGATGCAGGAATGGTTTATGTTAGTTAATAAGAAAAATGCCTTAATA
AGGAGAATGAATCAGCTCTCTCTTCTGGAAAAAGAACATGATTTAGAACGACGGTATGAGCTGCTGAACCGGGAATTGAGGGCAATGCTAGCCATTGAAGACTGGCAGAAGACCGAGGCCCAGAAGCGACGCGAACAGCTTCTGCTAGAT
GAGCTGGTGGCCCTGGTGAACAAGCGCGATGCGCTCGTCAGGGACCTGGACGCGCAGGAGAAGCAGGCCGAAGAAGAAGATGAGCATTTGGAGCGAACTCTGGAGCAAAACAAAGGCAAGATGGCCAAGAAAGAGGAGAAATGTGTTCTT
CAGTAGCCATCAGATCAGAAAGAATCTCTCCCAACATTTTAGAGTCTTGCTTCCCAAACCAGAAAAAGTCAGACTCATTGTTGATTTAAAACTTTTAACATTTTGTTTGGCTGGATTGTACTACTTTACCTCTACTTTACCACCACCACC
CTTTTCCTCCCTCCTTTCCAAATAATATACAGAACTCCAAAATAGCTTCATTTAAGGATTTTTTTGTGAGTTAACAATTTCCTTGAAATCCTGTGAAATAGATTTGCACAGACACCTTGTGAGTGATTGGTATTGGAGGTGTTCAAGAAA
CTGTTCGAAAAAGAACAAAAACACTTCCCTCGTTATTTTCTCTCATTTTTTGATGAGAGGAAAATTTGAAACATTATTCTTGTTGTTGTTGGTAATAGCATAATGACAGTGGGAGGGGTACAAGGGGATAAGAAAAATGTCATGATTTTT
TTCCGGTCCTGCCACATGTAACACTTACTCTGTTACCTAAATTTTATAGTTAGATCATATCCAATCTACTTATTAAACTGTGTTCTATTTACCAGTGGAGTTTTTCTGCAGTGGTTGCGTTTCACTGTAAGGATAATGGAGTTCCTCTCC
TCTGCTTTCCTCAGAGGATGGTCCTTTAACATAGCCAGAAACAAGCCCTGTGGTTTGAAGGTGAGCTGTGAGGATGGGACTAATTGATATGCACCAGTTTACAAAGACAGTCTTATCATCCGAGAATACACCATCTTTTTCTCTGGATAA
TTATTTCTTACATCATGCTTGATTCCTACATTTTGTTGGGTCTCAACATTGGCTCACGAATGCTGTTAATATTTATTCTGTATTGATAAAAAGTCTGTCTTGCCACTACAAGTAAATCCCCCATTTAATATTTTCTTCTTTAGCATAGCA
CTGTCATTTTTTGTGAAAATGGTTATGTTTATTTATTACAATACTGAGTCATATATAAATTTTCAATAAAAGCAGAAACTTTCTTACCTTAAA

>RFC1_EHBP1_ENST00000418436_ENST00000354487_39343964_63169852 length=3390nt 
 Breakpoint=0nt
CCAAGCCCTATACCAAGTCCTGTTTTGGGGCGAAAGCCAAATGCTAGTCAGTCTTTGCTTGTATGGTGTAAAGAAGTTACAAAGAACTACCGAGGAGTAAAAATCACCAATTTTACTACATCGTGGAGAAATGGTTTATCTTTTTGTGCA
ATATTACACCACTTTAGACCAGATTTAATTGACTACAAGTCTCTGAATCCTCAAGATATTAAAGAGAACAACAAAAAGGCATACGATGGATTTGCCAGCATAGGAATTTCCCGATTATTGGAACCTTCTGATATGGTATTATTAGCAATT
CCTGATAAACTGACTGTTATGACTTATCTCTATCAAATAAGGGCACATTTCAGTGGCCAAGAACTAAATGTCGTTCAGATAGAGGAAAACAGCAGTAAAAGCACATATAAAGTTGGAAACTATGAAACAGATACAAACAGTTCTGTTGAT
CAAGAAAAATTCTATGCAGAGCTTAGTGATCTGAAGCGGGAGCCTGAACTACAACAGCCTATCAGCGGAGCAGTAGACTTCTTATCACAGGATGACTCTGTATTTGTAAATGATAGCGGGGTTGGAGAGTCAGAAAGTGAGCATCAAACT
CCTGATGATCACCTTAGTCCAAGCACAGCCTCCCCTTACTGTCGCAGGACTAAAAGTGACACAGAACCCCAGAAGTCTCAGCAGAGCTCTGGAAGGACTTCAGGATCTGATGACCCTGGAATATGTTCCAATACAGATTCAACCCAAGCA
CAGGTTTTGTTAGGCAAAAAGAGACTATTGAAAGCTGAGACTTTAGAATTGAGTGACTTATATGTTAGTGATAAGAAGAAGGATATGTCTCCACCCTTTATTTGTGAGGAGACAGATGAACAAAAGCTTCAAACTCTAGACATCGGTAGT
AACTTGGAGAAAGAAAAATTAGAGAATTCCAGATCCTTAGAATGCAGATCAGATCCAGAATCTCCTATCAAAAAAACAAGTTTATCTCCTACTTCTAAACTTGGATACTCATATAGTAGAGATCTAGACCTTGCTAAGAAAAAACATGCT
TCCCTGAGGCAGACGGAGTCTGATCCAGATGCTGATAGAACCACTTTAAATCATGCAGATCATTCATCAAAAATAGTCCAGCATCGATTGTTATCTAGACAAGAAGAACTTAAGGAAAGAGCAAGAGTTCTGCTTGAGCAAGCAAGAAGA
GATGCAGCCTTAAAGGCGGGGAATAAGCACAATACCAACACAGCCACCCCATTCTGCAACAGGCAGCTAAGTGATCAGCAAGATGAAGAGCGACGTCGGCAGCTGAGAGAGAGAGCTCGTCAGCTAATAGCAGAAGCTCGATCTGGAGTG
AAGATGTCAGAACTTCCCAGCTATGGTGAAATGGCTGCAGAAAAGTTGAAAGAAAGGTCAAAGGCATCTGGAGATGAAAATGATAATATTGAGATAGATACTAACGAGGAGATCCCTGAAGGCTTTGTTGTAGGAGGTGGAGATGAACTT
ACTAACTTAGAAAATGACCTTGATACTCCCGAACAAAACAGTAAGTTGGTGGACTTGAAGCTGAAGAAGCTCCTAGAAGTTCAGCCACAGGTGGCAAATTCACCCTCCAGTGCTGCCCAGAAAGCTGTAACTGAGAGCTCAGAGCAGGAC
ATGAAAAGTGGCACAGAAGATCTCCGGACTGAACGATTACAAAAAACAACAGAACGTTTTAGAAATCCTGTTGTGTTCAGCAAAGATTCTACAGTCAGAAAAACTCAACTTCAGTCTTTCAGCCAATATATTGAGAATAGACCAGAGATG
AAAAGGCAGAGATCAATACAGGAAGATACAAAGAAAGGAAATGAGGAGAAGGCAGCGATAACTGAAACTCAGAGGAAGCCATCAGAAGATGAAGTGCTTAATAAAGGGTTCAAAGACACCAGTCAGTATGTAGTAGGAGAATTGGCAGCA
CTAGAGAATGAGCAAAAGCAAATTGACACCCGTGCCGCGCTGGTGGAGAAGCGCCTTCGCTATCTCATGGACACAGGAAGGAACACAGAAGAAGAAGAAGCTATGATGCAGGAATGGTTTATGTTAGTTAATAAGAAAAATGCCTTAATA
AGGAGAATGAATCAGCTCTCTCTTCTGGAAAAAGAACATGATTTAGAACGACGGTATGAGCTGCTGAACCGGGAATTGAGGGCAATGCTAGCCATTGAAGACTGGCAGAAGACCGAGGCCCAGAAGCGACGCGAACAGCTTCTGCTAGAT
GAGCTGGTGGCCCTGGTGAACAAGCGCGATGCGCTCGTCAGGGACCTGGACGCGCAGGAGAAGCAGGCCGAAGAAGAAGATGAGCATTTGGAGCGAACTCTGGAGCAAAACAAAGGCAAGATGGCCAAGAAAGAGGAGAAATGTGTTCTT
CAGTAGCCATCAGATCAGAAAGAATCTCTCCCAACATTTTAGAGTCTTGCTTCCCAAACCAGAAAAAGTCAGACTCATTGTTGATTTAAAACTTTTAACATTTTGTTTGGCTGGATTGTACTACTTTACCTCTACTTTACCACCACCACC
CTTTTCCTCCCTCCTTTCCAAATAATATACAGAACTCCAAAATAGCTTCATTTAAGGATTTTTTTGTGAGTTAACAATTTCCTTGAAATCCTGTGAAATAGATTTGCACAGACACCTTGTGAGTGATTGGTATTGGAGGTGTTCAAGAAA
CTGTTCGAAAAAGAACAAAAACACTTCCCTCGTTATTTTCTCTCATTTTTTGATGAGAGGAAAATTTGAAACATTATTCTTGTTGTTGTTGGTAATAGCATAATGACAGTGGGAGGGGTACAAGGGGATAAGAAAAATGTCATGATTTTT
TTCCGGTCCTGCCACATGTAACACTTACTCTGTTACCTAAATTTTATAGTTAGATCATATCCAATCTACTTATTAAACTGTGTTCTATTTACCAGTGGAGTTTTTCTGCAGTGGTTGCGTTTCACTGTAAGGATAATGGAGTTCCTCTCC
TCTGCTTTCCTCAGAGGATGGTCCTTTAACATAGCCAGAAACAAGCCCTGTGGTTTGAAGGTGAGCTGTGAGGATGGGACTAATTGATATGCACCAGTTTACAAAGACAGTCTTATCATCCGAGAATACACCATCTTTTTCTCTGGATAA
TTATTTCTTACATCATGCTTGATTCCTACATTTTGTTGGGTCTCAACATTGGCTCACGAATGCTGTTAATATTTATTCTGTATTGATAAAAAGTCTGTCTTGCCACTACAAGTAAATCCCCCATTTAATATTTTCTTCTTTAGCATAGCA
CTGTCATTTTTTGTGAAAATGGTTATGTTTATTTATTACAATACTGAGTCATATATAAATTTTCAATAAAAGCAGAAACTTTCTTACCTT

>RFC1_EHBP1_ENST00000418436_ENST00000405015_39343964_63169852 length=2395nt 
 Breakpoint=0nt
CCAAGCCCTATACCAAGTCCTGTTTTGGGGCGAAAGCCAAATGCTAGTCAGTCTTTGCTTGTATGGTGTAAAGAAGTTACAAAGAACTACCGAGGAGTAAAAATCACCAATTTTACTACATCGTGGAGAAATGGTTTATCTTTTTGTGCA
ATATTACACCACTTTAGACCAGATTTAATTGACTACAAGTCTCTGAATCCTCAAGATATTAAAGAGAACAACAAAAAGGCATACGATGGATTTGCCAGCATAGGAATTTCCCGATTATTGGAACCTTCTGATATGGTATTATTAGCAATT
CCTGATAAACTGACTGTTATGACTTATCTCTATCAAATAAGGGCACATTTCAGTGGCCAAGAACTAAATGTCGTTCAGATAGAGGAAAACAGCAGTAAAAGCACATATAAAGTTGGAAACTATGAAACAGATACAAACAGTTCTGTTGAT
CAAGAAAAATTCTATGCAGAGCTTAGTGATCTGAAGCGGGAGCCTGAACTACAACAGCCTATCAGCGGAGCAGTAGACTTCTTATCACAGGATGACTCTGTATTTGTAAATGATAGCGGGGTTGGAGAGTCAGAAAGTGAGCATCAAACT
CCTGATGATCACCTTAGTCCAAGCACAGCCTCCCCTTACTGTCGCAGGACTAAAAGTGACACAGAACCCCAGAAGTCTCAGCAGAGCTCTGGAAGGACTTCAGGATCTGATGACCCTGGAATATGTTCCAATACAGATTCAACCCAAGCA
CAGGTTTTGTTAGGCAAAAAGAGACTATTGAAAGCTGAGACTTTAGAATTGAGTGACTTATATGTTAGTGATAAGAAGAAGGATATGTCTCCACCCTTTATTTGTGAGGAGACAGATGAACAAAAGCTTCAAACTCTAGACATCGGTAGT
AACTTGGAGAAAGAAAAATTAGAGAATTCCAGATCCTTAGAATGCAGATCAGATCCAGAATCTCCTATCAAAAAAACAAGTTTATCTCCTACTTCTAAACTTGGATACTCATATAGTAGAGATCTAGACCTTGCTAAGAAAAAACATGCT
TCCCTGAGGCAGACGGAGTCTGATCCAGATGCTGATAGAACCACTTTAAATCATGCAGATCATTCATCAAAAATAGTCCAGCATCGATTGTTATCTAGACAAGAAGAACTTAAGGAAAGAGCAAGAGTTCTGCTTGAGCAAGCAAGAAGA
GATGCAGCCTTAAAGGCGGGGAATAAGCACAATACCAACACAGCCACCCCATTCTGCAACAGGCAGCTAAGTGATCAGCAAGATGAAGAGCGACGTCGGCAGCTGAGAGAGAGAGCTCGTCAGCTAATAGCAGAAGCTCGATCTGGAGTG
AAGATGTCAGAACTTCCCAGCTATGGTGAAATGGCTGCAGAAAAGTTGAAAGAAAGGTCAAAGGCATCTGGAGAACAAAACAGTAAGTTGGTGGACTTGAAGCTGAAGAAGCTCCTAGAAGTTCAGCCACAGGTGGCAAATTCACCCTCC
AGTGCTGCCCAGAAAGCTGTAACTGAGAGCTCAGAGCAGGACATGAAAAGTGGCACAGAAGATCTCCGGACTGAACGATTACAAAAAACAACAGAACGTTTTAGAAATCCTGTTGTGTTCAGCAAAGATTCTACAGTCAGAAAAACTCAA
CTTCAGTCTTTCAGCCAATATATTGAGAATAGACCAGAGATGAAAAGGCAGAGATCAATACAGGAAGATACAAAGAAAGGAAATGAGGAGAAGGCAGCGATAACTGAAACTCAGAGGAAGCCATCAGAAGATGAAGTGCTTAATAAAGGG
TTCAAAGACACCAGTCAGTATGTAGTAGGAGAATTGGCAGCACTAGAGAATGAGCAAAAGCAAATTGACACCCGTGCCGCGCTGGTGGAGAAGCGCCTTCGCTATCTCATGGACACAGGAAGGAACACAGAAGAAGAAGAAGCTATGATG
CAGGAATGGTTTATGTTAGTTAATAAGAAAAATGCCTTAATAAGGAGAATGAATCAGCTCTCTCTTCTGGAAAAAGAACATGATTTAGAACGACGGTATGAGCTGCTGAACCGGGAATTGAGGGCAATGCTAGCCATTGAAGACTGGCAG
AAGACCGAGGCCCAGAAGCGACGCGAACAGCTTCTGCTAGATGAGCTGGTGGCCCTGGTGAACAAGCGCGATGCGCTCGTCAGGGACCTGGACGCGCAGGAGAAGCAGGCCGAAGAAGAAGATGAGCATTTGGAGCGAACTCTGGAGCAA
AACAAAGGCAAGATGGCCAAGAAAGAGGAGAAATGTGTTCTTCAGTAGCCATCAGATCAGAAAGAATCTCTCCCAACATTTTAGAGTCTTGCTTCCCAAACCAGAAAAAGTCAGACTCATTGTTGATTTAAAACTTTTAACATTT

>RFC1_EHBP1_ENST00000418436_ENST00000405289_39343964_63169852 length=2406nt 
 Breakpoint=0nt
CCAAGCCCTATACCAAGTCCTGTTTTGGGGCGAAAGCCAAATGCTAGTCAGTCTTTGCTTGTATGGTGTAAAGAAGTTACAAAGAACTACCGAGGAGTAAAAATCACCAATTTTACTACATCGTGGAGAAATGGTTTATCTTTTTGTGCA
ATATTACACCACTTTAGACCAGATTTAATTGACTACAAGTCTCTGAATCCTCAAGATATTAAAGAGAACAACAAAAAGGCATACGATGGATTTGCCAGCATAGGAATTTCCCGATTATTGGAACCTTCTGATATGGTATTATTAGCAATT
CCTGATAAACTGACTGTTATGACTTATCTCTATCAAATAAGGGCACATTTCAGTGGCCAAGAACTAAATGTCGTTCAGATAGAGGAAAACAGCAGTAAAAGCACATATAAAGTTGGAAACTATGAAACAGATACAAACAGTTCTGTTGAT
CAAGAAAAATTCTATGCAGAGCTTAGTGATCTGAAGCGGGAGCCTGAACTACAACAGCCTATCAGCGGAGCAGTAGACTTCTTATCACAGGATGACTCTGTATTTGTAAATGATAGCGGGGTTGGAGAGTCAGAAAGTGAGCATCAAACT
CCTGATGATCACCTTAGTCCAAGCACAGCCTCCCCTTACTGTCGCAGGACTAAAAGTGACACAGAACCCCAGAAGTCTCAGCAGAGCTCTGGAAGGACTTCAGGATCTGATGACCCTGGAATATGTTCCAATACAGATTCAACCCAAGCA
CAGGTTTTGTTAGGCAAAAAGAGACTATTGAAAGCTGAGACTTTAGAATTGAGTGACTTATATGTTAGTGATAAGAAGAAGGATATGTCTCCACCCTTTATTTGTGAGGAGACAGATGAACAAAAGCTTCAAACTCTAGACATCGGTAGT
AACTTGGAGAAAGAAAAATTAGAGAATTCCAGATCCTTAGAATGCAGATCAGATCCAGAATCTCCTATCAAAAAAACAAGTTTATCTCCTACTTCTAAACTTGGATACTCATATAGTAGAGATCTAGACCTTGCTAAGAAAAAACATGCT
TCCCTGAGGCAGACGGAGTCTGATCCAGATGCTGATAGAACCACTTTAAATCATGCAGATCATTCATCAAAAATAGTCCAGCATCGATTGTTATCTAGACAAGAAGAACTTAAGGAAAGAGCAAGAGTTCTGCTTGAGCAAGCAAGAAGA
GATGCAGCCTTAAAGGCGGGGAATAAGCACAATACCAACACAGCCACCCCATTCTGCAACAGGCAGCTAAGTGATCAGCAAGATGAAGAGCGACGTCGGCAGCTGAGAGAGAGAGCTCGTCAGCTAATAGCAGAAGCTCGATCTGGAGTG
AAGATGTCAGAACTTCCCAGCTATGGTGAAATGGCTGCAGAAAAGTTGAAAGAAAGGTCAAAGGCATCTGGAGATGAAAATGATAATATTGAGATAGATACTAACGAGGAGATCCCTGAAGGCTTTGTTGTAGGAGGTGGAGATGAACTT
ACTAACTTAGAAAATGACCTTGATACTCCCGAACAAAACAGTAAGTTGGTGGACTTGAAGCTGAAGAAGCTCCTAGAAGTTCAGCCACAGGTGGCAAATTCACCCTCCAGTGCTGCCCAGAAAGCTGTAACTGAGAGCTCAGAGCAGGAC
ATGAAAAGTGGCACAGAAGATCTCCGGACTGAACGATTACAAAAAACAACAGAACGTTTTAGAAATCCTGTTGTGTTCAGCAAAGATTCTACAGTCAGAAAAACTCAACTTCAGTCTTTCAGCCAATATATTGAGAATAGACCAGAGATG
AAAAGGCAGAGATCAATACAGGAAGATACAAAGAAAGGAAATGAGGAGAAGGCAGCGATAACTGAAACTCAGAGGAAGCCATCAGAAGATGAAGTGCTTAATAAAGGGTTCAAAGACACCAGTCAGTATGTAGTAGGAGAATTGGCAGCA
CTAGAGAATGAGCAAAAGCAAATTGACACCCGTGCCGCGCTGGTGGAGAAGCGCCTTCGCTATCTCATGGACACAGGAAGGAACACAGAAGAAGAAGAAGCTATGATGCAGGAATGGTTTATGTTAGTTAATAAGAAAAATGCCTTAATA
AGGAGAATGAATCAGCTCTCTCTTCTGGAAAAAGAACATGATTTAGAACGACGGTATGAGCTGCTGAACCGGGAATTGAGGGCAATGCTAGCCATTGAAGACTGGCAGAAGACCGAGGCCCAGAAGCGACGCGAACAGCTTCTGCTAGAT
GAGCTGGTGGCCCTGGTGAACAAGCGCGATGCGCTCGTCAGGGACCTGGACGCGCAGGAGAAGCAGGCCGAAGAAGAAGATGAGCATTTGGAGCGAACTCTGGAGCAAAACAAAGGCAAGATGGCCAAGAAAGAGGAGAAATGTGTTCTT
CAGTAG

>RFC1_EHBP1_ENST00000418436_ENST00000431489_39343964_63169852 length=3285nt 
 Breakpoint=0nt
CCAAGCCCTATACCAAGTCCTGTTTTGGGGCGAAAGCCAAATGCTAGTCAGTCTTTGCTTGTATGGTGTAAAGAAGTTACAAAGAACTACCGAGGAGTAAAAATCACCAATTTTACTACATCGTGGAGAAATGGTTTATCTTTTTGTGCA
ATATTACACCACTTTAGACCAGATTTAATTGACTACAAGTCTCTGAATCCTCAAGATATTAAAGAGAACAACAAAAAGGCATACGATGGATTTGCCAGCATAGGAATTTCCCGATTATTGGAACCTTCTGATATGGTATTATTAGCAATT
CCTGATAAACTGACTGTTATGACTTATCTCTATCAAATAAGGGCACATTTCAGTGGCCAAGAACTAAATGTCGTTCAGATAGAGGAAAACAGCAGTAAAAGCACATATAAAGTTGGAAACTATGAAACAGATACAAACAGTTCTGTTGAT
CAAGAAAAATTCTATGCAGAGCTTAGTGATCTGAAGCGGGAGCCTGAACTACAACAGCCTATCAGCGGAGCAGTAGACTTCTTATCACAGGATGACTCTGTATTTGTAAATGATAGCGGGGTTGGAGAGTCAGAAAGTGAGCATCAAACT
CCTGATGATCACCTTAGTCCAAGCACAGCCTCCCCTTACTGTCGCAGGACTAAAAGTGACACAGAACCCCAGAAGTCTCAGCAGAGCTCTGGAAGGACTTCAGGATCTGATGACCCTGGAATATGTTCCAATACAGATTCAACCCAAGCA
CAGGTTTTGTTAGGCAAAAAGAGACTATTGAAAGCTGAGACTTTAGAATTGAGTGACTTATATGTTAGTGATAAGAAGAAGGATATGTCTCCACCCTTTATTTGTGAGGAGACAGATGAACAAAAGCTTCAAACTCTAGACATCGGTAGT
AACTTGGAGAAAGAAAAATTAGAGAATTCCAGATCCTTAGAATGCAGATCAGATCCAGAATCTCCTATCAAAAAAACAAGTTTATCTCCTACTTCTAAACTTGGATACTCATATAGTAGAGATCTAGACCTTGCTAAGAAAAAACATGCT
TCCCTGAGGCAGACGGAGTCTGATCCAGATGCTGATAGAACCACTTTAAATCATGCAGATCATTCATCAAAAATAGTCCAGCATCGATTGTTATCTAGACAAGAAGAACTTAAGGAAAGAGCAAGAGTTCTGCTTGAGCAAGCAAGAAGA
GATGCAGCCTTAAAGGCGGGGAATAAGCACAATACCAACACAGCCACCCCATTCTGCAACAGGCAGCTAAGTGATCAGCAAGATGAAGAGCGACGTCGGCAGCTGAGAGAGAGAGCTCGTCAGCTAATAGCAGAAGCTCGATCTGGAGTG
AAGATGTCAGAACTTCCCAGCTATGGTGAAATGGCTGCAGAAAAGTTGAAAGAAAGGTCAAAGGCATCTGGAGAACAAAACAGTAAGTTGGTGGACTTGAAGCTGAAGAAGCTCCTAGAAGTTCAGCCACAGGTGGCAAATTCACCCTCC
AGTGCTGCCCAGAAAGCTGTAACTGAGAGCTCAGAGCAGGACATGAAAAGTGGCACAGAAGATCTCCGGACTGAACGATTACAAAAAACAACAGAACGTTTTAGAAATCCTGTTGTGTTCAGCAAAGATTCTACAGTCAGAAAAACTCAA
CTTCAGTCTTTCAGCCAATATATTGAGAATAGACCAGAGATGAAAAGGCAGAGATCAATACAGGAAGATACAAAGAAAGGAAATGAGGAGAAGGCAGCGATAACTGAAACTCAGAGGAAGCCATCAGAAGATGAAGTGCTTAATAAAGGG
TTCAAAGACACCAGTCAGTATGTAGTAGGAGAATTGGCAGCACTAGAGAATGAGCAAAAGCAAATTGACACCCGTGCCGCGCTGGTGGAGAAGCGCCTTCGCTATCTCATGGACACAGGAAGGAACACAGAAGAAGAAGAAGCTATGATG
CAGGAATGGTTTATGTTAGTTAATAAGAAAAATGCCTTAATAAGGAGAATGAATCAGCTCTCTCTTCTGGAAAAAGAACATGATTTAGAACGACGGTATGAGCTGCTGAACCGGGAATTGAGGGCAATGCTAGCCATTGAAGACTGGCAG
AAGACCGAGGCCCAGAAGCGACGCGAACAGCTTCTGCTAGATGAGCTGGTGGCCCTGGTGAACAAGCGCGATGCGCTCGTCAGGGACCTGGACGCGCAGGAGAAGCAGGCCGAAGAAGAAGATGAGCATTTGGAGCGAACTCTGGAGCAA
AACAAAGGCAAGATGGCCAAGAAAGAGGAGAAATGTGTTCTTCAGTAGCCATCAGATCAGAAAGAATCTCTCCCAACATTTTAGAGTCTTGCTTCCCAAACCAGAAAAAGTCAGACTCATTGTTGATTTAAAACTTTTAACATTTTGTTT
GGCTGGATTGTACTACTTTACCTCTACTTTACCACCACCACCCTTTTCCTCCCTCCTTTCCAAATAATATACAGAACTCCAAAATAGCTTCATTTAAGGATTTTTTTGTGAGTTAACAATTTCCTTGAAATCCTGTGAAATAGATTTGCA
CAGACACCTTGTGAGTGATTGGTATTGGAGGTGTTCAAGAAACTGTTCGAAAAAGAACAAAAACACTTCCCTCGTTATTTTCTCTCATTTTTTGATGAGAGGAAAATTTGAAACATTATTCTTGTTGTTGTTGGTAATAGCATAATGACA
GTGGGAGGGGTACAAGGGGATAAGAAAAATGTCATGATTTTTTTCCGGTCCTGCCACATGTAACACTTACTCTGTTACCTAAATTTTATAGTTAGATCATATCCAATCTACTTATTAAACTGTGTTCTATTTACCAGTGGAGTTTTTCTG
CAGTGGTTGCGTTTCACTGTAAGGATAATGGAGTTCCTCTCCTCTGCTTTCCTCAGAGGATGGTCCTTTAACATAGCCAGAAACAAGCCCTGTGGTTTGAAGGTGAGCTGTGAGGATGGGACTAATTGATATGCACCAGTTTACAAAGAC
AGTCTTATCATCCGAGAATACACCATCTTTTTCTCTGGATAATTATTTCTTACATCATGCTTGATTCCTACATTTTGTTGGGTCTCAACATTGGCTCACGAATGCTGTTAATATTTATTCTGTATTGATAAAAAGTCTGTCTTGCCACTA
CAAGTAAATCCCCCATTTAATATTTTCTTCTTTAGCATAGCACTGTCATTTTTTGTGAAAATGGTTATGTTTATTTATTACAATACTGAGTCATATATAAATTTTCAATAAAAGCAGAAACTTTCTTACCTTAAA

C-Truncated Transcript (5CDS-3UTR) Sequences

Top

Fusion Protein Sequence for RFC1_EHBP1

In-frame Fusion Protein Sequences.

N-Truncated Protein (5UTR-3CDS) Sequences

>RFC1_EHBP1_ENST00000418436_ENST00000263991_39343964_63169852 length=93nt
MSMPTGFGTPAPYSLPTSFSGSFQQPAFPAQAAFPQQTAFSQQPNGFAAFGQTKPVVTPFGQVAAAGVSSNPFMTGAPTGQFPTGSSSTNPFL

>RFC1_EHBP1_ENST00000418436_ENST00000354487_39343964_63169852 length=74nt
MIMCTHKVHTLPMLNNAKKHNILMQQFSKINIKMSPDHQTKAKHLFPNSTMLKIDSNPKTPPTFLKSCQSPTIF

>RFC1_EHBP1_ENST00000418436_ENST00000405015_39343964_63169852 length=82nt
MPASASQSAGITGVSHRARPNYFFFLSFLTVQSFLWMKSCSEAQYAKERKTAGLDGCWEWGKTPTTQNHPPNTHTHSLHGDW

>RFC1_EHBP1_ENST00000418436_ENST00000405289_39343964_63169852 length=757nt
MGRKPNASQSLLVWCKEVTKNYRGVKITNFTTSWRNGLSFCAILHHFRPDLIDYKSLNPQDIKENNKKAYDGFASIGISRLLEPSDMVLLAIPDKLTVMTYLYQIRAHFSGQELNVVQIEENSSKSTYKVGNYETDTNSSVDQEKFYAEL
SDLKREPELQQPISGAVDFLSQDDSVFVNDSGVGESESEHQTPDDHLSPSTASPYCRRTKSDTEPQKSQQSSGRTSGSDDPGICSNTDSTQAQVLLGKKRLLKAETLELSDLYVSDKKKDMSPPFICEETDEQKLQTLDIGSNLEKEKLE
NSRSLECRSDPESPIKKTSLSPTSKLGYSYSRDLDLAKKKHASLRQTESDPDADRTTLNHADHSSKIVQHRLLSRQEELKERARVLLEQARRDAALKAGNKHNTNTATPFCNRQLSDQQDEERRRQLRERARQLIAEARSGVKMSELPSY
GEMAAEKLKERSKASGEQNSKLVDLKLKKLLEVQPQVANSPSSAAQKAVTESSEQDMKSGTEDLRTERLQKTTERFRNPVVFSKDSTVRKTQLQSFSQYIENRPEMKRQRSIQEDTKKGNEEKAAITETQRKPSEDEVLNKGFKDTSQYV
VGELAALENEQKQIDTRAALVEKRLRYLMDTGRNTEEEEAMMQEWFMLVNKKNALIRRMNQLSLLEKEHDLERRYELLNRELRAMLAIEDWQKTEAQKRREQLLLDELVALVNKRDALVRDLDAQEKQAEEEDEHLERTLEQNKGKMAKK
EEKCVLQ

>RFC1_EHBP1_ENST00000418436_ENST00000431489_39343964_63169852 length=793nt
MGRKPNASQSLLVWCKEVTKNYRGVKITNFTTSWRNGLSFCAILHHFRPDLIDYKSLNPQDIKENNKKAYDGFASIGISRLLEPSDMVLLAIPDKLTVMTYLYQIRAHFSGQELNVVQIEENSSKSTYKVGNYETDTNSSVDQEKFYAEL
SDLKREPELQQPISGAVDFLSQDDSVFVNDSGVGESESEHQTPDDHLSPSTASPYCRRTKSDTEPQKSQQSSGRTSGSDDPGICSNTDSTQAQVLLGKKRLLKAETLELSDLYVSDKKKDMSPPFICEETDEQKLQTLDIGSNLEKEKLE
NSRSLECRSDPESPIKKTSLSPTSKLGYSYSRDLDLAKKKHASLRQTESDPDADRTTLNHADHSSKIVQHRLLSRQEELKERARVLLEQARRDAALKAGNKHNTNTATPFCNRQLSDQQDEERRRQLRERARQLIAEARSGVKMSELPSY
GEMAAEKLKERSKASGDENDNIEIDTNEEIPEGFVVGGGDELTNLENDLDTPEQNSKLVDLKLKKLLEVQPQVANSPSSAAQKAVTESSEQDMKSGTEDLRTERLQKTTERFRNPVVFSKDSTVRKTQLQSFSQYIENRPEMKRQRSIQE
DTKKGNEEKAAITETQRKPSEDEVLNKGFKDTSQYVVGELAALENEQKQIDTRAALVEKRLRYLMDTGRNTEEEEAMMQEWFMLVNKKNALIRRMNQLSLLEKEHDLERRYELLNRELRAMLAIEDWQKTEAQKRREQLLLDELVALVNK
RDALVRDLDAQEKQAEEEDEHLERTLEQNKGKMAKKEEKCVLQ

C-Truncated Protein (5CDS-3UTR) Sequences

Top

Personalized Fusion Protein Sequence for RFC1_EHBP1

TCGA Kinase/DNA-binding Domain Mutated Fusion Protein Sequences

Num

Gene Group

Domain Loci

Fusion Protein ID

Fusion Gene Name

Partner

Mutated Residue in WT Protein

Seq. Length

Mutated Residue in Fusion Protein

CCLE Kinase/DNA-binding Domain Mutated Fusion Protein Sequences

Num

Gene Group

Domain Loci

Fusion Protein ID

Fusion Gene Name

Partner

Mutated Residue in WT Protein

Seq. Length

Mutated Residue in Fusion Protein

TCGA All Mutated Fusion Protein Sequences

Fusion Protein ID

Sample ID

Mutated Partner

AAchange in WT

Seq. Length

AAchange in Fusion

CCLE All Mutated Fusion Protein Sequences

Fusion Protein ID

Sample ID

Mutated Partner

AAchange in WT

Seq. Length

AAchange in Fusion

Top

Fusion Gene Exprssed Samples for RFC1_EHBP1

RNA-seq based fusion gene expressed samples.

Source	Study	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB		CESC	TCGA-VS-A8EC-01A	RFC1	chr4	39343964	-	EHBP1	chr2	39343964	+
WashU		CESC	TCGA-VS-A8EC-01A	RFC1	chr4	39343965	-	EHBP1	chr2	63169853	+
cBioPortal	CESC_TCGA_PAN_CAN_ATLAS_2018	CESC	TCGA-VS-A8EC-01	RFC1	chr4	39342345		EHBP1	chr2	62942718

DNA-seq based fusion gene expressed samples.

Source

Study

Disease

Sample

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

SV type

Top

Related Drugs for RFC1_EHBP1

PubMed Abstract Search With ['A-B' AND 'drug'], ['A::B' AND 'drug']
* For more details on the Studied, Reported, Approved Drugs targeting this fusion gene, Go to FusionPub.

PMID

Fusion Gene Name

Drug

Study Title

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status