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	Fusion Gene Summary
	Fusion Gene Breakpoints
	Tumorigenic MoA (Mechanism of Action) Scenarios of Fusion Geness
	Fusion Genomic Features
	Fusion Gene ORF Annotations
	Fusion Protein Retained/Non-Retained Functional Features
	Fusion Transcript Sequences
	Fusion Protein Sequences
	Personalized Fusion Protein Sequences
	Fusion Gene Expressed Samples
	Related Drugs

Fusion gene:DNAJC1_DCLRE1C (FusionGDB2 ID:HG64215TG64421)

Fusion Gene Summary for DNAJC1_DCLRE1C

Fusion gene summary

Fusion gene information	Fusion gene name: DNAJC1_DCLRE1C
	Fusion gene ID: hg64215tg64421
		Hgene	Tgene
	Gene symbol	DNAJC1	DCLRE1C
	Gene ID	64215	64421
	Gene name	DnaJ heat shock protein family (Hsp40) member C1	DNA cross-link repair 1C
	Synonyms	DNAJL1\|ERdj1\|HTJ1\|MTJ1	A-SCID\|DCLREC1C\|RS-SCID\|SCIDA\|SNM1C
	Cytomap	10p12.31	10p13
	Type of gene	protein-coding	protein-coding
	Description	dnaJ homolog subfamily C member 1DnaJ (Hsp40) homolog, subfamily C, member 1DnaJ-like proteindnaJ protein homolog MTJ1	protein artemisDNA cross-link repair 1C (PSO2 homolog, S. cerevisiae)SNM1 homolog CSNM1-like proteinsevere combined immunodeficiency, type a (Athabascan)
	Modification date	20240305	20240407
	UniProtAcc	.	.
	Ensembl transtripts involved in fusion gene	ENST00000376980, ENST00000376946, ENST00000483085,
Fusion gene scores	* DoF score	* DoF score (Degree of Frequency) = # partners X # break points X # disease types 16 X 17 X 8=2176	* DoF score (Degree of Frequency) = # partners X # break points X # disease types 6 X 7 X 6=252
	# samples	26	16
	** MAII score	** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score10) log2(26/217610)=-3.06509502822188 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score10) log2(16/25210)=-0.655351828612554 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: DNAJC1 [Title/Abstract] AND DCLRE1C [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	DNAJC1(22171210)-DCLRE1C(14941311), # samples:1

Fusion gene breakpoints across DNAJC1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across DCLRE1C (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Breakpoints for DNAJC1_DCLRE1C

RNA-seq based exon junction arranged fusion gene breakpoints from 8 resources (TCGA, CCLE, cBioPortal, GenBank, ChimerDB, ChimerKB, ChildHoodFusions, and GTEx). For the expressed sample information, go to Fusion Gene Sample section.

Hgene	Hchr	Hbp	Tgene	Tchr	Tbp
DNAJC1	chr10	22171210	DCLRE1C	chr10	14941311
DNAJC1	chr10	22171211	DCLRE1C	chr10	14941311
DNAJC1	chr10	21882282	DCLRE1C	chr10	14899312

DNA-seq based exon junction arranged fusion gene breakpoints from dbVar. For the expressed sample information, go to Fusion Gene Sample section.

Hgene

Hchr

Hbp

Tgene

Tchr

Tbp

SV type

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Tumorigenic MoA (Mechanism of Action) Scenarios of Fusion Genes for DNAJC1_DCLRE1C

To generate these tumorigenic scenario annotations, we implemented a deduction-first, retrieval-later computational framework. The pipeline first applies rule-guided reasoning across ten core mechanistic categories (M1–M10) derived from fusion gene biology to infer candidate mechanisms, tumorigenic scenarios, targeting points, and targeting backgrounds. To ensure empirical accountability, a governed Python workflow retrieves literature candidates via NCBI E-utilities and Europe PMC using tiered searches. Using JSON Schema-constrained LLM evidence judges (GPT-5.6 Luna and Terra), retrieved articles are evaluated for specificity and confidence without de novo PMID generation. This produces two distinct versions: a strict version restricted to high- or medium-confidence fusion-specific evidence, and an extended version incorporating broader gene-, pathway-, and contextual evidence.

* We have 10 tumorigenic mechanism categories of fusion genes as shown below.

Constitutively Active Kinases, Catalytic Domain Dysregulation, & Transmembrane Ligand Fusions	Aberrant Chimeric Transcription Factor / Fusion Transcription Factor Activity	Epigenetic Reprogramming / Histone Modifier Dysregulation	Chromatin Remodeling Dysregulation	Condensate-Driven Transcriptional Rewiring / LLP	Promoter / Enhancer Hijacking	Dominant-Negative Antagonism	Cell Cycle / Checkpoint Bypass / RNA Processing Dysregulation	Subcellular Mislocalization / Spatial Dysregulation	Nuclear Body / Sub-organellar Architecture Disruption & Differentiation Blockade

* Strict version: Restricted to high- or medium-confidence fusion-specific evidence.

Fusion Gene Name	Mechanism Category	Mechanism PubMed	Tumorigenic Scenarios	Tumorigenic Scenario PubMed	Targeting Points	Targeting PubMed	Mechanism Background	Mechanism Background PubMed
DNAJC1-DCLRE1C	Cell Cycle / Checkpoint Bypass / RNA Processing Dysregulation M8		Disruption of Artemis endonuclease (DCLRE1C) impairs non-homologous end joining (NHEJ) repair of DNA double-strand breaks[cite: 10, 20].		PARP inhibitors; DNA-PK inhibitors; platinum salts		Genomically unstable hematologic and solid tumors[cite: 10, 20]

* Extended version: Includes all strict-level fusion evidence plus broader gene-, pathway-, and low-confidence contextual evidence.

Fusion Gene Name	Mechanism Category	Mechanism PubMed	Tumorigenic Scenarios	Tumorigenic Scenario PubMed	Targeting Points	Targeting PubMed	Mechanism Background	Mechanism Background PubMed
DNAJC1-DCLRE1C	Cell Cycle / Checkpoint Bypass / RNA Processing Dysregulation M8		Disruption of Artemis endonuclease (DCLRE1C) impairs non-homologous end joining (NHEJ) repair of DNA double-strand breaks[cite: 10, 20].	Evidence level: Indirect gene evidence; Confidence: Medium; PMID: 38397417; Title: Dclre1c-Mutation-Induced Immunocompromised Mice Are a Novel Model for Human Xenograft Research.	PARP inhibitors; DNA-PK inhibitors; platinum salts		Genomically unstable hematologic and solid tumors[cite: 10, 20]	Evidence level: Limited indirect gene evidence; Confidence: Low; PMID: 38397417; Title: Dclre1c-Mutation-Induced Immunocompromised Mice Are a Novel Model for Human Xenograft Research.; PMID: 37901335; Title: A novel splice donor mutation in DCLRE1C caused atypical severe combined immunodeficiency in a patient with colon lymphoma: case report and literature review.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	DNAJC1	GO:0050708	regulation of protein secretion	14668352

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Fusion Genomic Features for DNAJC1_DCLRE1C

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence) of In-frame fusion genes. FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
DNAJC1	chr10	22171210	-	DCLRE1C	chr10	14941311	-	8.90e-06	1.00e+00

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence) of 5UTR-3CSD fusion genes (N-truncated cases).

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence) of 5CDS-3UTR fusion genes (C-truncated cases).

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of six genomic regulatory feature tracks across a ±5 kb window centered on the fusion breakpoints. We input the breakpoint sequences into AlphaGenome and obtained predicted genome tracks at single-base-pair resolution for each modality by running a single forward pass over the reference sequence. Specifically, for each breakpoint, AlphaGenome processed and returned predicted track data across diverse modalities, which were then averaged across all tracks within each output type and visualized across the ±5 kb window. The left panel shows the 5'-gene breakpoint ±5 kb area, and the right panel shows the 3'-gene breakpoint area, with tracks grouped by category: chromatin accessibility (DNase-seq, ATAC-seq), active transcription (RNA-seq, CAGE), and chromatin binding (ChIP-Histone, ChIP-TF).

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Fusion Gene ORF Annotations for DNAJC1_DCLRE1C

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
In-frame	ENST00000376980	ENST00000378289	DNAJC1	chr10	22171210	-	DCLRE1C	chr10	14941311	-

ORFfinder Result Based On The Fusion Transcript Sequences of the In-frame Fusion Genes.

Henst	Tenst	Hgene	Hchr	Hbp	Tgene	Tchr	Tbp	Seq length (transcript)	Seq length (peptide)
ENST00000376980	ENST00000378289	DNAJC1	chr10	22171210	DCLRE1C	chr10	14941311	1269	141

ORFfinder Result Based On The Fusion Transcript Sequences of the 5UTR-3CDS Fusion Genes for N-Truncated Protein Search.

Henst

Tenst

Hgene

Hchr

Hbp

Tgene

Tchr

Tbp

Seq length
(transcript)

Seq length
(peptide)

ORFfinder Result Based On The Fusion Transcript Sequences of the 5CDS-3UTR Fusion Genes for C-Truncated Protein Search.

Henst

Tenst

Hgene

Hchr

Hbp

Tgene

Tchr

Tbp

Seq length
(transcript)

Seq length
(peptide)

DeepORF Prediction of The Coding Potential Based on The Fusion Transcript Sequence of In-frame Fusion Genes. DeepORF is a Coding Potential Classifier Based on Convolutional Neural Network by Comparing the Real Ribo-seq Data. If the No-coding Score < 0.5 and Coding Score > 0.5, Then The In-frame Fusion Transcript is Predicted as Being Likely Translated.

Henst	Tenst	Hgene	Hchr	Hbp	Tgene	Tchr	Tbp	No-coding score	Coding score
ENST00000376980	ENST00000378289	DNAJC1	chr10	22171210	DCLRE1C	chr10	14941311	2.96e-03	9.97e-01

DeepORF Prediction of The Coding Potential Based on The Fusion Transcript Sequence of 5UTR-3CDS Fusion Genes (Potential N-Truncated Proteins).

Henst

Tenst

Hgene

Hchr

Hbp

Tgene

Tchr

Tbp

No-coding score

Coding score

DeepORF Prediction of The Coding Potential Based on The Fusion Transcript Sequence of 5CDS-3UTR Fusion Genes (Potential C-Truncated Proteins).

Henst

Tenst

Hgene

Hchr

Hbp

Tgene

Tchr

Tbp

No-coding score

Coding score

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Fusion Protein Retained/Non-Retained Functional Features for DNAJC1_DCLRE1C

Protein Level Annotation from FGviewer
* Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at download page. Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features (visualization across fusion protein length).

DNAJC1_DCLRE1C_chr10-22171210_chr10-14941311.png

- In-frame and retained protein feature among the 13 regional features (texts).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

DNAJC1

chr10:22171210

chr10:14941311

ENST00000376980

Q96KC8

65_129

326.0

555.0

Domain

Hgene

DNAJC1

chr10:22171210

chr10:14941311

ENST00000376980

Q96KC8

48_153

326.0

555.0

Topological domain

Lumenal

Hgene

DNAJC1

chr10:22171210

chr10:14941311

ENST00000376980

Q96KC8

154_174

326.0

555.0

Transmembrane

Helical

Tgene

DCLRE1C

chr10:22171210

chr10:14941311

ENST00000378289

Q96SD1

506_520

385.3333333333333

435.0

Compositional bias

Polar residues

Tgene

DCLRE1C

chr10:22171210

chr10:14941311

ENST00000378289

Q96SD1

530_543

385.3333333333333

435.0

Compositional bias

Low complexity

Tgene

DCLRE1C

chr10:22171210

chr10:14941311

ENST00000378289

Q96SD1

544_555

385.3333333333333

435.0

Compositional bias

Polar residues

Tgene

DCLRE1C

chr10:22171210

chr10:14941311

ENST00000378289

Q96SD1

640_650

385.3333333333333

435.0

Compositional bias

Polar residues

Tgene

DCLRE1C

chr10:22171210

chr10:14941311

ENST00000378289

Q96SD1

504_555

385.3333333333333

435.0

Region

Disordered

Tgene

DCLRE1C

chr10:22171210

chr10:14941311

ENST00000378289

Q96SD1

640_664

385.3333333333333

435.0

Region

Disordered

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

DNAJC1

chr10:22171210

chr10:14941311

ENST00000376980

Q96KC8

392_405

326.0

555.0

Compositional bias

Polar residues

Hgene

DNAJC1

chr10:22171210

chr10:14941311

ENST00000376980

Q96KC8

421_432

326.0

555.0

Compositional bias

Acidic residues

Hgene

DNAJC1

chr10:22171210

chr10:14941311

ENST00000376980

Q96KC8

455_472

326.0

555.0

Compositional bias

Basic and acidic residues

Hgene

DNAJC1

chr10:22171210

chr10:14941311

ENST00000376980

Q96KC8

473_482

326.0

555.0

Compositional bias

Acidic residues

Hgene

DNAJC1

chr10:22171210

chr10:14941311

ENST00000376980

Q96KC8

483_494

326.0

555.0

Compositional bias

Basic and acidic residues

Hgene

DNAJC1

chr10:22171210

chr10:14941311

ENST00000376980

Q96KC8

325_379

326.0

555.0

Domain

SANT 1

Hgene

DNAJC1

chr10:22171210

chr10:14941311

ENST00000376980

Q96KC8

492_547

326.0

555.0

Domain

SANT 2

Hgene

DNAJC1

chr10:22171210

chr10:14941311

ENST00000376980

Q96KC8

392_500

326.0

555.0

Region

Disordered

Hgene

DNAJC1

chr10:22171210

chr10:14941311

ENST00000376980

Q96KC8

175_554

326.0

555.0

Topological domain

Cytoplasmic

- Retained PPIs in in-frame fusion.

Partner

Hgene

Hbp

Tgene

Tbp

ENST

UniProt

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Hgene

Hbp

Tgene

Tbp

ENST

UniProt

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Fusion Transcript Sequence for DNAJC1_DCLRE1C

In-frame Fusion Transcript Sequences.

>DNAJC1_DCLRE1C_ENST00000376980_ENST00000378289_22171210_14941311 length=3223nt 
 Breakpoint=1269nt
GCAGCCCAGGCGCCGGGCGCTGCCTCTACAGCTGTGTGTAGGCCTGGGGGCGAGGGTCTTCGGAACGTAGCGCTGGCTGCGGCCCCGCCCGCCTACCCACCCGCCCGTCCGGCAGCCGGCTCCCGCCGCCTCCGCGCTCTGTCTGGGGCC
AGCCACCTGGCGGGCCGCTCCGGTGCGCCTGCCCGCGCTTTTCACTGACAGGCGCTGTTCCCCACAGCCAGCGCCGCCCGCCACGTCCCAGCTCTCGGCCAACGGAGCTGCGCGGCGGGTGACCTTTCCGAGCCCAGCGCGATGACGGCT
CCTTGCTCCCAGCCGGCGCAGCTTCCTGGACGCCGCCAGCTCGGGCTGGTGCCGTTCCCGCCGCCGCCGCCGCGGACGCCGCTGCTGTGGCTGCTGCTGCTGCTGCTGGCCGCCGTGGCGCCGGCGCGCGGCTGGGAGAGCGGAGACCTG
GAGTTGTTTGACTTAGTGGAGGAGGTGCAGCTCAACTTCTACCAGTTCCTCGGGGTGCAGCAGGATGCATCATCTGCAGACATCAGAAAAGCATATCGTAAGCTTTCACTAACTTTACATCCAGACAAGAATAAAGATGAAAATGCAGAA
ACTCAGTTTAGACAATTGGTGGCCATTTATGAAGTTTTAAAGGATGATGAACGAAGGCAGAGGTATGATGATATTCTGATCAATGGACTTCCAGATTGGCGACAGCCTGTATTCTACTACAGGCGGGTGAGAAAAATGAGCAATGCTGAG
CTGGCATTACTCTTGTTCATTATTCTCACAGTGGGTCATTATGCTGTGGTTTGGTCAATCTACCTGGAAAAACAACTGGATGAACTACTAAGTAGAAAAAAGAGAGAAAAGAAAAAAAAGACTGGCAGCAAGAGTGTGGATGTATCAAAA
CTCGGTGCTTCAGAAAAAAATGAAAGATTGCTGATGAAACCACAGTGGCATGATTTGCTTCCATGCAAACTGGGGATTTGGTTTTGCCTTACACTAAAAGCATTACCTCACCTCATCCAGGATGCTGGGCAGTTTTATGCTAAATATAAA
GAAACAAGATTGAAGGAAAAGGAAGATGCACTGACTAGAACTGAACTTGAAACACTTCAAAAACAGAAGAAAGTTAAAAAACCAAAACCTGAATTTCCTGTATACACACCTTTAGAAACTACATATATTCAGTCTTATGATCATGGAACT
TCCATAGAAGAAATTGAGGAACAAATGGATGATTGGTTGGAAAACAGGAACCGAACACAGAAAAAACAGGGTCTCACTCTGTCACTCAGGCTAGAATGCGGTGGTGCCATCATGACTCCCTGTATCCTTTAACTCCTGGGATCAAGCGAT
CTTCCTGCCTCAGCCTCCTGACTAGCTGGATCACAGGTGCATACCGCCATGCCCAGCTAATGATTTAGTTTTTATAGAGATGTGGGGTCTCACTATGTTGCCCACACTGGTCTGGAACTCCTGGGCTCAAGTGAGCCTCCAGCCTTGACC
TCCCCAAGTGCTGGGATTAACTGTAACTGGTTGATTTATGACTTTTTAAACAGGATTTGAGCAGTACATTGGAACACTGCATTACTTTCATTATAATTAGGATGTTCAAAAAGCTATACAACTATAGCTCTCTACAGGACACAACTGAAT
GTTAAGGACTAAATCTGCAAGTATATGCTCTAAATATGATCCAGGCACATTTTTCCTATAACTTATATATATGCAGTTACAAATGGAAAATTGTTAAAAATACAGGGGAGAAGCTATGTTAACTTTGGAATGGAAGGTTTTGTTTTTGTA
GAATATGTTATTTTCATGCAATTCTGTAAGTCTAAGATCGTCATCTACAGTTCTGCTCTTAAGAACACAAGTTTTATGACACGCTCGGCTTAAGAAACCAAAAGTGTCTAAAGTACTTTATGTTACCAACCAAATTTGGCTGCTGCACTC
ATTAAGAATGCAACTTAAAAAATTTTGGTTAACAAAAAGAGTAATTTGATTATACAAGATCTTGTATACTGAATAATTTATAATAATCTACCACTGTCTAAAAGTGTAAGAATCAAAACAGCCATCTAATTTAGTTTCAGAATTATAGAT
GAATACAGATAATTATAGGTGACCCAATTCCAACTAAAAAATCCAGAGTTGACAACTCCAGATATGTAGCCATGCTTGTGTCTTTCTAGTCACAGCTCAACCTACCCTTCAGTTTGAAGCAGTGTGGTGCCATGGTGAAGACTACTGATT
TTAGAGCTTTGAATCTCGGTTCTTATTACTATGTGACCTGTGTGACCTTGGGCAAGGTACTCAATTTCTCTACAATAATGGACATAACAGTACTACTTCTCAAAAAAAAAAAAAAAAAAAAAAAAAAAAGAAACAGTACTACCTCACTGA
GTTTTGGAGAGGATTAGTGAATTAATACATCAAGTGCTTAGAATAGTATGTGACACACGGCAAATACTTTTTACATTTATATATATATATACATATATATGATTTGTATACAAATAAATTTGCTAGTATTTGTATGGTAGTTTTGAGAAT
GGTCTTCACAGTTCAAAAGTAAGTTACAGATTATGGATGCAATAAATGCTTGTGTATATTTTACAAAACTCATAAATATAGTATCTTTCATGTTGATCCAAAATAGAGTTCTGCCAACTACATTTAATCATATTTGGTCAAATAGATGAA
GTAAATTAAAACTTTCAAGTTTCAAAGCAGCATGTGTTACATCTGAGTTTCTTCTTAGGACTTTTGGGTAAAAACAGTTGTCATATTTTAAATTTTACAAATCCTAGGTTTGACTAGTAGGAATGTGTATTTGTTGAAAGATGACTATAT
CAATTTGTTTTAACGTATATTTTTTATTCATATAAAAGTTTTTTATTTCTAAATATGCCAGTGAACTCTTCTCCTAAATCTGAATAAATTTCTACATATCTGCAAATGAAAATATCAAAATGTACCAAGTATCTCTTAAAGAGATAAAAA
GGTAATTTTCCAAAAGTATAAACCTTGCATGTCCATCATTTACTACGTGGCAAATGAAACATACCTCTCCAACATATTCCATGACAAAACTCATTCTTTTAATCTTCACAAGGGTCTTTACACCCCAGCCACGTCCATTGCTAGTTCGAA
AGATGCAAAGCGAATACTGTGTGCCTTTTTGTACAATCCTATTGGGACAATCAGGACCACACTGACACCTTGA

N-Truncated Transcript (5UTR-3CDS) Sequences

C-Truncated Transcript (5CDS-3UTR) Sequences

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Fusion Protein Sequence for DNAJC1_DCLRE1C

In-frame Fusion Protein Sequences.

>DNAJC1_DCLRE1C_ENST00000376980_ENST00000378289_22171210_14941311 length=141nt
MQAMKHMEPQVKQVFQSLPKSEAATFAREQGFETKDIKEIAKKTQALPKMNSKRQRIVIFTQGRDDTIMATESEVTAFAVLDQDQKEIIDTNGAGDAFVGGFLSQLVSDKPLTECIRAGHYAASIIIRRTGCTFPEKPDFH

N-Truncated Protein (5UTR-3CDS) Sequences

C-Truncated Protein (5CDS-3UTR) Sequences

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Personalized Fusion Protein Sequence for DNAJC1_DCLRE1C

TCGA Kinase/DNA-binding Domain Mutated Fusion Protein Sequences

Num

Gene Group

Domain Loci

Fusion Protein ID

Fusion Gene Name

Partner

Mutated Residue in WT Protein

Seq. Length

Mutated Residue in Fusion Protein

CCLE Kinase/DNA-binding Domain Mutated Fusion Protein Sequences

Num

Gene Group

Domain Loci

Fusion Protein ID

Fusion Gene Name

Partner

Mutated Residue in WT Protein

Seq. Length

Mutated Residue in Fusion Protein

TCGA All Mutated Fusion Protein Sequences

Fusion Protein ID

Sample ID

Mutated Partner

AAchange in WT

Seq. Length

AAchange in Fusion

CCLE All Mutated Fusion Protein Sequences

Fusion Protein ID

Sample ID

Mutated Partner

AAchange in WT

Seq. Length

AAchange in Fusion

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Fusion Gene Exprssed Samples for DNAJC1_DCLRE1C

RNA-seq based fusion gene expressed samples.

Source	Study	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB		BRCA	TCGA-A8-A081-01A	DNAJC1	chr10	22171210	-	DCLRE1C	chr10	14941311	-
ChimerDB		BRCA	TCGA-A8-A081-01A	DNAJC1	chr10	22171211	-	DCLRE1C	chr10	14941311	-
TCGAfusionPortal		BRCA	TCGA-A8-A081-01A	DNAJC1	chr10	22171211	-	DCLRE1C	chr10	14941311	-
WashU		BRCA	TCGA-A8-A081-01A	DNAJC1	chr10	22171211	-	DCLRE1C	chr10	14941311	-
cBioPortal	BRCA_TCGA_PAN_CAN_ATLAS_2018	BRCA	TCGA-A8-A081-01	DNAJC1	chr10	21882282		DCLRE1C	chr10	14899312

DNA-seq based fusion gene expressed samples.

Source

Study

Disease

Sample

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

SV type

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Related Drugs for DNAJC1_DCLRE1C

PubMed Abstract Search With ['A-B' AND 'drug'], ['A::B' AND 'drug']
* For more details on the Studied, Reported, Approved Drugs targeting this fusion gene, Go to FusionPub.

PMID

Fusion Gene Name

Drug

Study Title

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status