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	Fusion Gene Summary
	Fusion Gene Breakpoints
	Tumorigenic MoA (Mechanism of Action) Scenarios of Fusion Geness
	Fusion Genomic Features
	Fusion Gene ORF Annotations
	Fusion Protein Retained/Non-Retained Functional Features
	Fusion Transcript Sequences
	Fusion Protein Sequences
	Personalized Fusion Protein Sequences
	Fusion Gene Expressed Samples
	Related Drugs

Fusion gene:ANKRD33B_ADAMTS16 (FusionGDB2 ID:HG651746TG170690)

Fusion Gene Summary for ANKRD33B_ADAMTS16

Fusion gene summary

Fusion gene information	Fusion gene name: ANKRD33B_ADAMTS16
	Fusion gene ID: hg651746tg170690
		Hgene	Tgene
	Gene symbol	ANKRD33B	ADAMTS16
	Gene ID	651746	170690
	Gene name	ankyrin repeat domain 33B	ADAM metallopeptidase with thrombospondin type 1 motif 16
	Synonyms	-	ADAMTS16s
	Cytomap	5p15.2	5p15.32
	Type of gene	protein-coding	protein-coding
	Description	ankyrin repeat domain-containing protein 33BAnkyrin repeat domain-containing protein LOC651746	A disintegrin and metalloproteinase with thrombospondin motifs 16ADAM-TS 16ADAM-TS16ADAMTS-16a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 16
	Modification date	20240305	20240403
	UniProtAcc	A6NCL7	.
	Ensembl transtripts involved in fusion gene	ENST00000296657,
Fusion gene scores	* DoF score	* DoF score (Degree of Frequency) = # partners X # break points X # disease types 7 X 2 X 7=98	* DoF score (Degree of Frequency) = # partners X # break points X # disease types 5 X 15 X 6=450
	# samples	14	11
	** MAII score	** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score10) log2(14/9810)=0.514573172829758 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0	** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score10) log2(11/45010)=-2.03242147769238 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: ANKRD33B [Title/Abstract] AND ADAMTS16 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	ANKRD33B(10564945)-ADAMTS16(5232480), # samples:1

Fusion gene breakpoints across ANKRD33B (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across ADAMTS16 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Breakpoints for ANKRD33B_ADAMTS16

RNA-seq based exon junction arranged fusion gene breakpoints from 8 resources (TCGA, CCLE, cBioPortal, GenBank, ChimerDB, ChimerKB, ChildHoodFusions, and GTEx). For the expressed sample information, go to Fusion Gene Sample section.

Hgene	Hchr	Hbp	Tgene	Tchr	Tbp
ANKRD33B	chr5	10564945	ADAMTS16	chr5	10564945
ANKRD33B	chr5	10564945	ADAMTS16	chr5	5232481

DNA-seq based exon junction arranged fusion gene breakpoints from dbVar. For the expressed sample information, go to Fusion Gene Sample section.

Hgene

Hchr

Hbp

Tgene

Tchr

Tbp

SV type

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Tumorigenic MoA (Mechanism of Action) Scenarios of Fusion Genes for ANKRD33B_ADAMTS16

To generate these tumorigenic scenario annotations, we implemented a deduction-first, retrieval-later computational framework. The pipeline first applies rule-guided reasoning across ten core mechanistic categories (M1–M10) derived from fusion gene biology to infer candidate mechanisms, tumorigenic scenarios, targeting points, and targeting backgrounds. To ensure empirical accountability, a governed Python workflow retrieves literature candidates via NCBI E-utilities and Europe PMC using tiered searches. Using JSON Schema-constrained LLM evidence judges (GPT-5.6 Luna and Terra), retrieved articles are evaluated for specificity and confidence without de novo PMID generation. This produces two distinct versions: a strict version restricted to high- or medium-confidence fusion-specific evidence, and an extended version incorporating broader gene-, pathway-, and contextual evidence.

* We have 10 tumorigenic mechanism categories of fusion genes as shown below.

Constitutively Active Kinases, Catalytic Domain Dysregulation, & Transmembrane Ligand Fusions	Aberrant Chimeric Transcription Factor / Fusion Transcription Factor Activity	Epigenetic Reprogramming / Histone Modifier Dysregulation	Chromatin Remodeling Dysregulation	Condensate-Driven Transcriptional Rewiring / LLP	Promoter / Enhancer Hijacking	Dominant-Negative Antagonism	Cell Cycle / Checkpoint Bypass / RNA Processing Dysregulation	Subcellular Mislocalization / Spatial Dysregulation	Nuclear Body / Sub-organellar Architecture Disruption & Differentiation Blockade

* Strict version: Restricted to high- or medium-confidence fusion-specific evidence.

Fusion Gene Name	Mechanism Category	Mechanism PubMed	Tumorigenic Scenarios	Tumorigenic Scenario PubMed	Targeting Points	Targeting PubMed	Mechanism Background	Mechanism Background PubMed
ANKRD33B-ADAMTS16	Promoter / Enhancer Hijacking M6		Promoter swap alters ADAMTS16 metalloproteinase expression, remodeling the tumor ECM to facilitate local tissue invasion.		MMP/ADAMTS inhibitors; standard chemotherapy		Carcinomas

* Extended version: Includes all strict-level fusion evidence plus broader gene-, pathway-, and low-confidence contextual evidence.

Fusion Gene Name	Mechanism Category	Mechanism PubMed	Tumorigenic Scenarios	Tumorigenic Scenario PubMed	Targeting Points	Targeting PubMed	Mechanism Background	Mechanism Background PubMed
ANKRD33B-ADAMTS16	Promoter / Enhancer Hijacking M6		Promoter swap alters ADAMTS16 metalloproteinase expression, remodeling the tumor ECM to facilitate local tissue invasion.	Evidence level: Indirect gene evidence; Confidence: Medium; PMID: 39551781; Title: ADAMTS16 drives epithelial-mesenchymal transition and metastasis through a feedback loop upon TGF-Î²1 activation in lung adenocarcinoma.; PMID: 36232317; Title: The Novel Protein ADAMTS16 Promotes Gastric Carcinogenesis by Targeting IFI27 through the NF-Îºb Signaling Pathway.	MMP/ADAMTS inhibitors; standard chemotherapy		Carcinomas	Evidence level: Indirect gene evidence; Confidence: Medium; PMID: 30081852; Title: Aberrant DNA methylation of ADAMTS16 in colorectal and other epithelial cancers.; PMID: 39551781; Title: ADAMTS16 drives epithelial-mesenchymal transition and metastasis through a feedback loop upon TGF-Î²1 activation in lung adenocarcinoma.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
ANKRD33B A6NCL7	.

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

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Fusion Genomic Features for ANKRD33B_ADAMTS16

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence) of In-frame fusion genes. FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
ANKRD33B	chr5	10564945	+	ADAMTS16	chr5	5232480	+	4.18e-03	9.96e-01

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence) of 5UTR-3CSD fusion genes (N-truncated cases).

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence) of 5CDS-3UTR fusion genes (C-truncated cases).

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of six genomic regulatory feature tracks across a ±5 kb window centered on the fusion breakpoints. We input the breakpoint sequences into AlphaGenome and obtained predicted genome tracks at single-base-pair resolution for each modality by running a single forward pass over the reference sequence. Specifically, for each breakpoint, AlphaGenome processed and returned predicted track data across diverse modalities, which were then averaged across all tracks within each output type and visualized across the ±5 kb window. The left panel shows the 5'-gene breakpoint ±5 kb area, and the right panel shows the 3'-gene breakpoint area, with tracks grouped by category: chromatin accessibility (DNase-seq, ATAC-seq), active transcription (RNA-seq, CAGE), and chromatin binding (ChIP-Histone, ChIP-TF).

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Fusion Gene ORF Annotations for ANKRD33B_ADAMTS16

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
In-frame	ENST00000296657	ENST00000274181	ANKRD33B	chr5	10564945	+	ADAMTS16	chr5	5232480	+

ORFfinder Result Based On The Fusion Transcript Sequences of the In-frame Fusion Genes.

Henst	Tenst	Hgene	Hchr	Hbp	Tgene	Tchr	Tbp	Seq length (transcript)	Seq length (peptide)
ENST00000296657	ENST00000274181	ANKRD33B	chr5	10564945	ADAMTS16	chr5	5232480	366	222

ORFfinder Result Based On The Fusion Transcript Sequences of the 5UTR-3CDS Fusion Genes for N-Truncated Protein Search.

Henst

Tenst

Hgene

Hchr

Hbp

Tgene

Tchr

Tbp

Seq length
(transcript)

Seq length
(peptide)

ORFfinder Result Based On The Fusion Transcript Sequences of the 5CDS-3UTR Fusion Genes for C-Truncated Protein Search.

Henst

Tenst

Hgene

Hchr

Hbp

Tgene

Tchr

Tbp

Seq length
(transcript)

Seq length
(peptide)

DeepORF Prediction of The Coding Potential Based on The Fusion Transcript Sequence of In-frame Fusion Genes. DeepORF is a Coding Potential Classifier Based on Convolutional Neural Network by Comparing the Real Ribo-seq Data. If the No-coding Score < 0.5 and Coding Score > 0.5, Then The In-frame Fusion Transcript is Predicted as Being Likely Translated.

Henst	Tenst	Hgene	Hchr	Hbp	Tgene	Tchr	Tbp	No-coding score	Coding score
ENST00000296657	ENST00000274181	ANKRD33B	chr5	10564945	ADAMTS16	chr5	5232480	1.32e-04	1.00e+00

DeepORF Prediction of The Coding Potential Based on The Fusion Transcript Sequence of 5UTR-3CDS Fusion Genes (Potential N-Truncated Proteins).

Henst

Tenst

Hgene

Hchr

Hbp

Tgene

Tchr

Tbp

No-coding score

Coding score

DeepORF Prediction of The Coding Potential Based on The Fusion Transcript Sequence of 5CDS-3UTR Fusion Genes (Potential C-Truncated Proteins).

Henst

Tenst

Hgene

Hchr

Hbp

Tgene

Tchr

Tbp

No-coding score

Coding score

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Fusion Protein Retained/Non-Retained Functional Features for ANKRD33B_ADAMTS16

Protein Level Annotation from FGviewer
* Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at download page. Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features (visualization across fusion protein length).

ANKRD33B_ADAMTS16_chr5-10564945_chr5-5232480.png

- In-frame and retained protein feature among the 13 regional features (texts).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

ANKRD33B

chr5:10564945

chr5:5232480

ENST00000296657

A6NCL7

30_42

122.0

495.0

Compositional bias

Acidic residues

Hgene

ANKRD33B

chr5:10564945

chr5:5232480

ENST00000296657

A6NCL7

1_80

122.0

495.0

Region

Disordered

Hgene

ANKRD33B

chr5:10564945

chr5:5232480

ENST00000296657

A6NCL7

84_113

122.0

495.0

Repeat

Note=ANK 1

Tgene

ADAMTS16

chr5:10564945

chr5:5232480

ENST00000274181

Q8TE57

1051_1115

567.0

1225.0

Domain

TSP type-1 5

Tgene

ADAMTS16

chr5:10564945

chr5:5232480

ENST00000274181

Q8TE57

1127_1181

567.0

1225.0

Domain

TSP type-1 6

Tgene

ADAMTS16

chr5:10564945

chr5:5232480

ENST00000274181

Q8TE57

1186_1223

567.0

1225.0

Domain

PLAC

Tgene

ADAMTS16

chr5:10564945

chr5:5232480

ENST00000274181

Q8TE57

586_641

567.0

1225.0

Domain

TSP type-1 1

Tgene

ADAMTS16

chr5:10564945

chr5:5232480

ENST00000274181

Q8TE57

874_922

567.0

1225.0

Domain

TSP type-1 2

Tgene

ADAMTS16

chr5:10564945

chr5:5232480

ENST00000274181

Q8TE57

927_987

567.0

1225.0

Domain

TSP type-1 3

Tgene

ADAMTS16

chr5:10564945

chr5:5232480

ENST00000274181

Q8TE57

988_1048

567.0

1225.0

Domain

TSP type-1 4

Tgene

ADAMTS16

chr5:10564945

chr5:5232480

ENST00000274181

Q8TE57

747_873

567.0

1225.0

Region

Note=Spacer

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

ANKRD33B

chr5:10564945

chr5:5232480

ENST00000296657

A6NCL7

459_488

122.0

495.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

ANKRD33B

chr5:10564945

chr5:5232480

ENST00000296657

A6NCL7

371_382

122.0

495.0

Compositional bias

Basic and acidic residues

Hgene

ANKRD33B

chr5:10564945

chr5:5232480

ENST00000296657

A6NCL7

440_451

122.0

495.0

Compositional bias

Basic and acidic residues

Hgene

ANKRD33B

chr5:10564945

chr5:5232480

ENST00000296657

A6NCL7

459_487

122.0

495.0

Compositional bias

Basic and acidic residues

Hgene

ANKRD33B

chr5:10564945

chr5:5232480

ENST00000296657

A6NCL7

349_494

122.0

495.0

Region

Disordered

Hgene

ANKRD33B

chr5:10564945

chr5:5232480

ENST00000296657

A6NCL7

120_150

122.0

495.0

Repeat

Note=ANK 2

Hgene

ANKRD33B

chr5:10564945

chr5:5232480

ENST00000296657

A6NCL7

154_183

122.0

495.0

Repeat

Note=ANK 3

Hgene

ANKRD33B

chr5:10564945

chr5:5232480

ENST00000296657

A6NCL7

189_218

122.0

495.0

Repeat

Note=ANK 4

Hgene

ANKRD33B

chr5:10564945

chr5:5232480

ENST00000296657

A6NCL7

223_255

122.0

495.0

Repeat

Note=ANK 5

Tgene

ADAMTS16

chr5:10564945

chr5:5232480

ENST00000274181

Q8TE57

40_50

567.0

1225.0

Compositional bias

Pro residues

Tgene

ADAMTS16

chr5:10564945

chr5:5232480

ENST00000274181

Q8TE57

290_495

567.0

1225.0

Domain

Peptidase M12B

Tgene

ADAMTS16

chr5:10564945

chr5:5232480

ENST00000274181

Q8TE57

496_585

567.0

1225.0

Domain

Note=Disintegrin

Tgene

ADAMTS16

chr5:10564945

chr5:5232480

ENST00000274181

Q8TE57

247_254

567.0

1225.0

Motif

Cysteine switch

Tgene

ADAMTS16

chr5:10564945

chr5:5232480

ENST00000274181

Q8TE57

31_53

567.0

1225.0

Region

Disordered

- Retained PPIs in in-frame fusion.

Partner

Hgene

Hbp

Tgene

Tbp

ENST

UniProt

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Hgene

Hbp

Tgene

Tbp

ENST

UniProt

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Fusion Transcript Sequence for ANKRD33B_ADAMTS16

In-frame Fusion Transcript Sequences.

>ANKRD33B_ADAMTS16_ENST00000296657_ENST00000274181_10564945_5232480 length=3506nt 
 Breakpoint=366nt
ATGGTGCTGCTGGCCGGGACCGGGCCGGAGGGCGGCGGGGCGCGCTGCATGACCCCACCACCGCCGTCCCCACCCCGGGGCGCGCAGGTCGAGGAGGACCCCGCTGACTACGAAGAGTTTGAGGACTTCTCGAGTCTGCCAGACACCCGC
AGCATCGCCTCGGACGACTCTTTCTACCCTTTCGAGGACGAGGAGGAGCACGGCGTCGAGAGCGCGGAGAGCGTCCCGGAGGGCGTCCCGGAAAGCGTCCCGGAGACGGCGACCCTCCTGCGCGCCGCCTGCGCCAACAACGTGGGGCTG
CTGCGGACGCTGGTGCGGCGCGGGGTGAGCGTCGAGGAGGCGCAGGAGACTGACCGCAACGGCAGGTGGTGCCGGGGAGGACAGTGTGTGAAATATGGTGATGAAGGCCCCAAGCCCACCCATGGCCACTGGTCGGACTGGTCTTCTTGG
TCCCCATGCTCCAGGACCTGCGGAGGGGGAGTATCTCATAGGAGTCGCCTCTGCACCAACCCCAAGCCATCGCATGGAGGGAAGTTCTGTGAGGGCTCCACTCGCACTCTGAAGCTCTGCAACAGTCAGAAATGTCCCCGGGACAGTGTT
GACTTCCGTGCTGCTCAGTGTGCCGAGCACAACAGCAGACGATTCAGAGGGCGGCACTACAAGTGGAAGCCTTACACTCAAGTAGAAGATCAGGACTTATGCAAACTCTACTGTATCGCAGAAGGATTTGATTTCTTCTTTTCTTTGTCA
AATAAAGTCAAAGATGGGACTCCATGCTCGGAGGATAGCCGTAATGTTTGTATAGATGGGATATGTGAGAGAGTTGGATGTGACAATGTCCTTGGATCTGATGCTGTTGAAGACGTCTGTGGGGTGTGTAACGGGAATAACTCAGCCTGC
ACGATTCACAGGGGTCTCTACACCAAGCACCACCACACCAACCAGTATTATCACATGGTCACCATTCCTTCTGGAGCCCGGAGTATCCGCATCTATGAAATGAACGTCTCTACCTCCTACATTTCTGTGCGCAATGCCCTCAGAAGGTAC
TACCTGAATGGGCACTGGACCGTGGACTGGCCCGGCCGGTACAAATTTTCGGGCACTACTTTCGACTACAGACGGTCCTATAATGAGCCCGAGAACTTAATCGCTACTGGACCAACCAACGAGACACTGATTGTGGAGCTGCTGTTTCAG
GGAAGGAACCCGGGTGTTGCCTGGGAATACTCCATGCCTCGCTTGGGGACCGAGAAGCAGCCCCCTGCCCAGCCCAGCTACACTTGGGCCATCGTGCGCTCTGAGTGCTCCGTGTCCTGCGGAGGGGGACAGATGACCGTGAGAGAGGGC
TGCTACAGAGACCTGAAGTTTCAAGTAAATATGTCCTTCTGCAATCCCAAGACACGACCTGTCACGGGGCTGGTGCCTTGCAAAGTATCTGCCTGTCCTCCCAGCTGGTCCGTGGGGAACTGGAGTGCCTGCAGTCGGACGTGTGGCGGG
GGTGCCCAGAGCCGCCCCGTGCAGTGCACACGGCGGGTGCACTATGACTCGGAGCCAGTCCCGGCCAGCCTGTGCCCTCAGCCTGCTCCCTCCAGCAGGCAGGCCTGCAACTCTCAGAGCTGCCCACCTGCATGGAGCGCCGGGCCCTGG
GCAGAGTGCTCACACACCTGTGGGAAGGGGTGGAGGAAGCGGGCAGTGGCCTGTAAGAGCACCAACCCCTCGGCCAGAGCGCAGCTGCTGCCCGACGCTGTCTGCACCTCCGAGCCCAAGCCCAGGATGCATGAAGCCTGTCTGCTTCAG
CGCTGCCACAAGCCCAAGAAGCTGCAGTGGCTGGTGTCCGCCTGGTCCCAGTGCTCTGTGACATGTGAAAGAGGAACACAGAAAAGATTCTTAAAATGTGCTGAAAAGTATGTTTCTGGAAAGTATCGAGAGCTGGCCTCAAAGAAGTGC
TCACATTTGCCGAAGCCCAGCCTGGAGCTGGAACGTGCCTGCGCCCCGCTTCCATGCCCCAGGCACCCCCCATTTGCTGCTGCGGGACCCTCGAGGGGCAGCTGGTTTGCCTCACCCTGGTCTCAGTGCACGGCCAGCTGTGGGGGAGGC
GTTCAGACGAGGTCCGTGCAGTGCCTGGCTGGGGGCCGGCCGGCCTCAGGCTGCCTCCTGCACCAGAAGCCTTCGGCCTCCCTGGCCTGCAACACTCACTTCTGCCCCATTGCAGAGAAGAAAGATGCCTTCTGCAAAGACTACTTCCAC
TGGTGCTACCTGGTACCCCAGCACGGGATGTGCAGCCACAAGTTCTACGGCAAGCAGTGCTGCAAGACTTGCTCTAAGTCCAACTTGTGAGTTGGGACCGCTCTCCGTAGCAGAGAAAGTGCCTGCGTGGCACAGAAATTTCCCACAAAT
GAGCTGTGCAATCTACGTCGGAATACATCCAAGGAAGAGCAAAGCCAAAAGAAGAAAACCGTGTTAGGCTCTTTGACCAGGAGTGTATGTATGTGTTTCACTGTGAGCCTGGGTGCAGACCTGTGTCCCCATGCACACAGTGTCTCCTGT
CAGGCTGAAATGTGGCACCCTGGCAGACAGAGCTGTGGCTCGTGAGGCAGAAGGCAGGCACCACAACGGGAGAGGCAGCACTCACCCCTGCCTGTTGCAGCTAAATCAAGTCAAAAAGACAGGCGAGGCTGAACTTGCTAAATGTCTGGT
GCCTTAGAAAAAGAAGGAAAGGCCATGAAATAAGGAAAACATACAAAATATGTACCCCCTAGTTCACCAGCCTCCCCTCCCACTAGGAGGGCCCCTCGAGCCATCAGGAGTGACCAACTTCCTGGGTGGAGGTCAGGGGAGCTCCAGGAG
GCTGCCCAGGCTCCTCCTCCTCCTCCCCAGCGGCCGAGCATCTCTTACCAGGAACCTGGAGCCACCGCCGGAGCCAGCGTCATCTCTAGGGTCACTGGCCAGGGGACTGCATTCTGGTTTGGGACTTTGCCTATGGAAATGGGAAAAATG
AAATTCCTGCTAAGGTGCTTCTATCTCTTTCAGATTCATGCATTGAAGGAGAGATTTTTTATACTTTATGTTTTATCTTTCTCAGTTATTTGCAAGTGAGTGTCCTTTTAAAAACACACTTCTTCATGCTTTTCTTTGTAAATGACAGAT
CGAAGTATAGGTTACATCAAAACCCTACCATCCTGAGAAGAGTTATGGTTCTATTATAGCAGACGTCAGCCACACAGCCTATGTGACAATAACCTTAGAGTCCTGTGTTTTGTTTTTGTGTGTTGTGAGATTTTAATCTTTTTTTTTTCG
GTGAGTCTGGCCATTTCTATAATGCCAGGTGGGAAGCCAGGCTGCGGGTGTTAGGGTGGGAATCTGCCCGGCGTCTCTGGCACCCTCCCTGCCATCCTCAGTGCGGCTGCTGTTCTCCTGTCCGGTGCTGTGGCTCCATTCCAAAGGGGC
ACCTGGATATTTATATTTGCTGAAGTTTTATAATAAAGTTTATATGGTACAGTGTG

N-Truncated Transcript (5UTR-3CDS) Sequences

C-Truncated Transcript (5CDS-3UTR) Sequences

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Fusion Protein Sequence for ANKRD33B_ADAMTS16

In-frame Fusion Protein Sequences.

>ANKRD33B_ADAMTS16_ENST00000296657_ENST00000274181_10564945_5232480 length=222nt
MAFLKLRDQELASKKSLPMNYYTVFYHVQEQLPRDCFVVSEGANTMDIGRTVLQNYLPRHRLDAGTFGTMGVGLGFAIAAAVVAKDRSPGQWIICVEGDSAFGFSGMEVETICRYNLPIILLVVNNNGIYQGFDTDTWKEMLKFQDATAV
VPPMCLLPNSHYEQVMTAFGGKGYFVQTPEELQKSLRQSLADTTKPSLINIMIEPQATRKAQDFHWLTRSNM

N-Truncated Protein (5UTR-3CDS) Sequences

C-Truncated Protein (5CDS-3UTR) Sequences

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Personalized Fusion Protein Sequence for ANKRD33B_ADAMTS16

TCGA Kinase/DNA-binding Domain Mutated Fusion Protein Sequences

Num

Gene Group

Domain Loci

Fusion Protein ID

Fusion Gene Name

Partner

Mutated Residue in WT Protein

Seq. Length

Mutated Residue in Fusion Protein

CCLE Kinase/DNA-binding Domain Mutated Fusion Protein Sequences

Num

Gene Group

Domain Loci

Fusion Protein ID

Fusion Gene Name

Partner

Mutated Residue in WT Protein

Seq. Length

Mutated Residue in Fusion Protein

TCGA All Mutated Fusion Protein Sequences

Fusion Protein ID

Sample ID

Mutated Partner

AAchange in WT

Seq. Length

AAchange in Fusion

CCLE All Mutated Fusion Protein Sequences

Fusion Protein ID

Sample ID

Mutated Partner

AAchange in WT

Seq. Length

AAchange in Fusion

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Fusion Gene Exprssed Samples for ANKRD33B_ADAMTS16

RNA-seq based fusion gene expressed samples.

Source	Study	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB		OV	TCGA-24-2026-01A	ANKRD33B	chr5	10564945	+	ADAMTS16	chr5	10564945	+
ChimerDB		OV	TCGA-24-2026	ANKRD33B	chr5	10564945	+	ADAMTS16	chr5	10564945	+
ChimerDB		UCEC	TCGA-B5-A11J	ANKRD33B	chr5	10564945	+	ADAMTS16	chr5	10564945	+
WashU		OV	TCGA-24-2026-01A	ANKRD33B	chr5	10564945	+	ADAMTS16	chr5	5232481	+

DNA-seq based fusion gene expressed samples.

Source

Study

Disease

Sample

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

SV type

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Related Drugs for ANKRD33B_ADAMTS16

PubMed Abstract Search With ['A-B' AND 'drug'], ['A::B' AND 'drug']
* For more details on the Studied, Reported, Approved Drugs targeting this fusion gene, Go to FusionPub.

PMID

Fusion Gene Name

Drug

Study Title

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status