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Fusion gene:DEK_NR1D2 (FusionGDB2 ID:HG7913TG9975) |
Fusion Gene Summary for DEK_NR1D2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: DEK_NR1D2 | Fusion gene ID: hg7913tg9975 | Hgene | Tgene | Gene symbol | DEK | NR1D2 | Gene ID | 7913 | 9975 |
| Gene name | DEK proto-oncogene | nuclear receptor subfamily 1 group D member 2 | |
| Synonyms | D6S231E | BD73|EAR-1R|REVERBB|REVERBbeta|RVR | |
| Cytomap | 6p22.3 | 3p24.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | protein DEKDEK oncogene (DNA binding) | nuclear receptor subfamily 1 group D member 2V-erbA-related protein 1-relatedorphan nuclear hormone receptor BD73rev-erb alpha-related receptorrev-erb-betarev-erba-alpha-related receptor | |
| Modification date | 20240411 | 20240411 | |
| UniProtAcc | P35659 | Q14995 | |
| Ensembl transtripts involved in fusion gene | ENST00000244776, ENST00000397239, | ||
| Fusion gene scores | * DoF score | * DoF score (Degree of Frequency) = # partners X # break points X # disease types 12 X 20 X 37=8880 | * DoF score (Degree of Frequency) = # partners X # break points X # disease types 2 X 7 X 4=56 |
| # samples | 56 | 5 | |
| ** MAII score | ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) log2(56/8880*10)=-3.9870609442925 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) log2(5/56*10)=-0.163498732282879 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: DEK [Title/Abstract] AND NR1D2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint | DEK(18236682)-NR1D2(24018713), # samples:1 | ||
| DEK-NR1D2 in-frame fusion transcripts reconstructed from RNA-seq breakpoints * For each RNA-seq based exon-junction breakpoint, we joined the Ensembl transcripts (ENST) whose exon boundaries match the breakpoint on each side: the 5'-gene ENST from its transcription start to the 5'-breakpoint and the 3'-gene ENST from the 3'-breakpoint to its transcription end, keeping only in-frame combinations. Each row is one fusion transcript: the DEK part (blue) joined at the breakpoint (red line) to the NR1D2 part (orange), both drawn 5' to 3'. GENCODE v19 transcripts of each gene are shown below in dark gray. View in the UCSC Genome Browser: DEK part, NR1D2 part |
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Fusion Gene Breakpoints for DEK_NR1D2 |
| RNA-seq based exon junction arranged fusion gene breakpoints from 8 resources (TCGA, CCLE, cBioPortal, GenBank, ChimerDB, ChimerKB, ChildHoodFusions, and GTEx). For the expressed sample information, go to Fusion Gene Sample section. |
| Hgene | Hchr | Hbp | Tgene | Tchr | Tbp |
| DEK | chr6 | 18236682 | NR1D2 | chr3 | 24018713 |
| DNA-seq based exon junction arranged fusion gene breakpoints from dbVar. For the expressed sample information, go to Fusion Gene Sample section. |
| Hgene | Hchr | Hbp | Tgene | Tchr | Tbp | SV type |
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Tumorigenic MoA (Mechanism of Action) Scenarios of Fusion Genes for DEK_NR1D2 |
| To generate these tumorigenic scenario annotations, we implemented a deduction-first, retrieval-later computational framework. The pipeline first applies rule-guided reasoning across ten core mechanistic categories (M1–M10) derived from fusion gene biology to infer candidate mechanisms, tumorigenic scenarios, targeting points, and targeting backgrounds. To ensure empirical accountability, a governed Python workflow retrieves literature candidates via NCBI E-utilities and Europe PMC using tiered searches. Using JSON Schema-constrained LLM evidence judges (GPT-5.6 Luna and Terra), retrieved articles are evaluated for specificity and confidence without de novo PMID generation. This produces two distinct versions: a strict version restricted to high- or medium-confidence fusion-specific evidence, and an extended version incorporating broader gene-, pathway-, and contextual evidence. |
| Constitutively Active Kinases, Catalytic Domain Dysregulation, & Transmembrane Ligand Fusions | Aberrant Chimeric Transcription Factor / Fusion Transcription Factor Activity | Epigenetic Reprogramming / Histone Modifier Dysregulation | Chromatin Remodeling Dysregulation | Condensate-Driven Transcriptional Rewiring / LLP | Promoter / Enhancer Hijacking | Dominant-Negative Antagonism | Cell Cycle / Checkpoint Bypass / RNA Processing Dysregulation | Subcellular Mislocalization / Spatial Dysregulation | Nuclear Body / Sub-organellar Architecture Disruption & Differentiation Blockade |  |  |  |  |  |  |  |  |  |  |
* Strict version: Restricted to high- or medium-confidence fusion-specific evidence.
| Fusion Gene Name | Mechanism Category | Mechanism PubMed | Tumorigenic Scenarios | Tumorigenic Scenario PubMed | Targeting Points | Targeting PubMed | Mechanism Background | Mechanism Background PubMed |
* Extended version: Includes all strict-level fusion evidence plus broader gene-, pathway-, and low-confidence contextual evidence.
| Fusion Gene Name | Mechanism Category | Mechanism PubMed | Tumorigenic Scenarios | Tumorigenic Scenario PubMed | Targeting Points | Targeting PubMed | Mechanism Background | Mechanism Background PubMed |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| DEK | NR1D2 |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | DEK | GO:0045945 | positive regulation of transcription by RNA polymerase III | 16603771 |
| Tgene | NR1D2 | GO:0045892 | negative regulation of DNA-templated transcription | 17892483|17996965 |
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Fusion Genomic Features for DEK_NR1D2 |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence) of In-frame fusion genes. FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| DEK | chr6 | 18236682 | - | NR1D2 | chr3 | 24018713 | + | 1.22e-06 | 1.00e+00 |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence) of 5UTR-3CSD fusion genes (N-truncated cases). |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence) of 5CDS-3UTR fusion genes (C-truncated cases). |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| Distribution of six genomic regulatory feature tracks across a ±5 kb window centered on the fusion breakpoints. We input the breakpoint sequences into AlphaGenome and obtained predicted genome tracks at single-base-pair resolution for each modality by running a single forward pass over the reference sequence. Specifically, for each breakpoint, AlphaGenome processed and returned predicted track data across diverse modalities, which were then averaged across all tracks within each output type and visualized across the ±5 kb window. The left panel shows the 5'-gene breakpoint ±5 kb area, and the right panel shows the 3'-gene breakpoint area, with tracks grouped by category: chromatin accessibility (DNase-seq, ATAC-seq), active transcription (RNA-seq, CAGE), and chromatin binding (ChIP-Histone, ChIP-TF). |
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Fusion Gene ORF Annotations for DEK_NR1D2 |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-3UTR | ENST00000244776 | ENST00000492552 | DEK | chr6 | 18236682 | - | NR1D2 | chr3 | 24018713 | + |
| 5CDS-3UTR | ENST00000397239 | ENST00000492552 | DEK | chr6 | 18236682 | - | NR1D2 | chr3 | 24018713 | + |
| In-frame | ENST00000244776 | ENST00000312521 | DEK | chr6 | 18236682 | - | NR1D2 | chr3 | 24018713 | + |
| In-frame | ENST00000397239 | ENST00000312521 | DEK | chr6 | 18236682 | - | NR1D2 | chr3 | 24018713 | + |
| ORFfinder Result Based On The Fusion Transcript Sequences of the In-frame Fusion Genes. |
| Henst | Tenst | Hgene | Hchr | Hbp | Tgene | Tchr | Tbp | Seq length (transcript) | Seq length (peptide) |
| ENST00000244776 | ENST00000312521 | DEK | chr6 | 18236682 | NR1D2 | chr3 | 24018713 | 4507 | 319 |
| ENST00000397239 | ENST00000312521 | DEK | chr6 | 18236682 | NR1D2 | chr3 | 24018713 | 4891 | 353 |
| ORFfinder Result Based On The Fusion Transcript Sequences of the 5UTR-3CDS Fusion Genes for N-Truncated Protein Search. |
| Henst | Tenst | Hgene | Hchr | Hbp | Tgene | Tchr | Tbp | Seq length (transcript) | Seq length (peptide) |
| ORFfinder Result Based On The Fusion Transcript Sequences of the 5CDS-3UTR Fusion Genes for C-Truncated Protein Search. |
| Henst | Tenst | Hgene | Hchr | Hbp | Tgene | Tchr | Tbp | Seq length (transcript) | Seq length (peptide) |
| DeepORF Prediction of The Coding Potential Based on The Fusion Transcript Sequence of In-frame Fusion Genes. DeepORF is a Coding Potential Classifier Based on Convolutional Neural Network by Comparing the Real Ribo-seq Data. If the No-coding Score < 0.5 and Coding Score > 0.5, Then The In-frame Fusion Transcript is Predicted as Being Likely Translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Tgene | Tchr | Tbp | No-coding score | Coding score |
| ENST00000244776 | ENST00000312521 | DEK | chr6 | 18236682 | NR1D2 | chr3 | 24018713 | 1.93e-03 | 9.98e-01 |
| ENST00000397239 | ENST00000312521 | DEK | chr6 | 18236682 | NR1D2 | chr3 | 24018713 | 1.38e-03 | 9.99e-01 |
| DeepORF Prediction of The Coding Potential Based on The Fusion Transcript Sequence of 5UTR-3CDS Fusion Genes (Potential N-Truncated Proteins). |
| Henst | Tenst | Hgene | Hchr | Hbp | Tgene | Tchr | Tbp | No-coding score | Coding score |
| DeepORF Prediction of The Coding Potential Based on The Fusion Transcript Sequence of 5CDS-3UTR Fusion Genes (Potential C-Truncated Proteins). |
| Henst | Tenst | Hgene | Hchr | Hbp | Tgene | Tchr | Tbp | No-coding score | Coding score |
| ENST00000244776 | ENST00000492552 | DEK | chr6 | 18236682 | NR1D2 | chr3 | 24018713 | 0.00e+00 | 7.29e-02 |
| ENST00000397239 | ENST00000492552 | DEK | chr6 | 18236682 | NR1D2 | chr3 | 24018713 | 0.00e+00 | 1.39e-01 |
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Fusion Protein Retained/Non-Retained Functional Features for DEK_NR1D2 |
| Protein Level Annotation from FGviewer * Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at download page. Minus value of BPloci means that the break pointn is located before the CDS. |
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| - View each breakpoint in FGviewer (DNA, RNA and protein levels; GRCh37). If you use FGviewer, please cite: Kim P, Yiya K, Zhou X. FGviewer: an online visualization tool for functional features of human fusion genes. Nucleic Acids Res. 2020;48(W1):W313-W320. doi:10.1093/nar/gkaa364 |
| Data | Hgene | Hchr | Hbp | Tgene | Tchr | Tbp | FGviewer |
| RNA-seq | DEK | chr6 | 18236682 | NR1D2 | chr3 | 24018713 | View |
| - In-frame and retained protein feature among the 13 regional features (visualization across fusion protein length). |
DEK_NR1D2_chr6-18236682_chr3-24018713.png |
| - In-frame and retained protein feature among the 13 regional features (texts). |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - Retained PPIs in in-frame fusion. |
| Partner | Hgene | Hbp | Tgene | Tbp | ENST | UniProt | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Hgene | Hbp | Tgene | Tbp | ENST | UniProt | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Fusion Transcript Sequence for DEK_NR1D2 |
| In-frame Fusion Transcript Sequences. |
>DEK_NR1D2_ENST00000244776_ENST00000312521_18236682_24018713 length=4507nt Breakpoint=1111aa ATTTTGAAAATCTTGTTGATTCTGGGGAGCCGAGCGCGCGGCGCGAGCGTCACGCCAGACAGCGGCCCGCGCGCCTTCTCCTCGGCGTCGGCCGCCGCCGCCTCCCAGAACCTCCTCGTGCCCTCGCGTGCCAGGCCCGCGGCGGCCGAA ATCCGCGGTTCACAGCATGTCCGCCTCGGCCCCTGCTGCGGAGGGGGAGGGAACCCCCACCCAGCCCGCGTCCGAGAAAGAACCCGAAATGCCCGGTCCCAGAGAGGAGAGCGAGGAGGAAGAGGACGAGGACGACGAGGAGGAGGAGGA GGAGGAAAAAGGAAAGGGGCAGAAACTTTGTGAAATTGAGAGGATACATTTTTTTCTAAGTAAGAAGAAAACCGATGAACTTAGAAATCTACACAAACTGCTTTACAACAGGCCAGGCACTGTGTCCTCATTAAAGAAGAATGTGGGTCA GTTCAGTGGCTTTCCATTTGAAAAAGGAAGTGTCCAATATAAAAAGAAGGAAGAAATGTTGAAAAAATTTAGAAATGCCATGTTAAAGAGCATCTGTGAGGTTCTTGATTTGGAGAGATCAGGTGTAAATAGTGAACTAGTGAAGAGGAT CTTGAATTTCTTAATGCATCCAAAGCCTTCTGGCAAACCATTGCCGAAATCTAAAAAAACTTGTAGCAAAGGCAGTAAAAAGGAACGGAACAGTTCTGGAATGGCAAGGAAGGCTAAGCGAACCAAATGTCCTGAAATTCTGTCAGATGA ATCTAGTAGTGATGAAGATGAAAAGAAAAACAAGGAAGAGTCTTCAGATGATGAAGATAAAGAAAGTGAAGAGGAGCCACCAAAAAAGACAGCCAAAAGAGAAAAACCTAAACAGAAAGCTACTTCTAAAAGTAAAAAATCTGTGAAAAG TGCCAATGTTAAGAAAGCAGATAGCAGCACCACCAAGAAGAATCAAAACAGTTCCAAAAAAGAAAGTGAGTCTGAGGATAGTTCAGATGATGAACCTTTAATTAAAAAGTTGAAGAAACCCCCTACAGATGAAGAGTTAAAGGAAACAAT AAAGAAATTACTGGCCAGTGCTAACTTGGAAGAAGTCACAATGAAACAGATTTGCAAAAAGATCGATCTGGAATAGAAAACGTCAACTCTGTGGAGGCTTTGCAGGAAACTCTCATTCGTGCACTAAGGACCTTAATAATGAAAAACCAT CCAAATGAGGCCTCTATTTTTACAAAACTGCTTCTAAAGTTGCCAGATCTTCGATCTTTAAACAACATGCACTCTGAGGAGCTCTTGGCCTTTAAAGTTCACCCTTAAGGCCTTTGTTTATTTAAACATGAACTGATGGTAACTGTACAT TTTGTGCTAAAATGCATATTTATATGTGTATACCATATGTGGAGATAGAAAAGACCTTTAAGACAATAAAAGATTGTAGGCTATCTCTGTAATCATGCAATAGCTGTTCGGATTGAGAACTCTTCAGCCATGATTAGACGTTGACTGCAT CTCCCTGATAGACCAATCAGCTGTGTCGCACTTAAACTGGAGAAGTTACACTGAAGTATAATCACACTGAATGTTAGACTTTTTCATCTGCCAAAACCAAAAACCATTTTGATCTCCCTGTGGTTATCAATATAACGCACAATCACAAGT GTATGAGGACTTAGAAATTAATCCTTTGTGGTAGGAGTTCTGTTGAATGATGGAAATCTTATTACTACCACAAGACTATTTGATCTGGTAATTGGAGACTTCGGGATTTAGGAGATCTCCATGTCTGTATTTACTCTACCACTGCTAAAG TGTGTGGTCCTGGGTAGTTTACTTGCTTGCGGAAAATGAGAATTGATGGTGTCCCCAATGCCCCACCTCACAGAGTTACTAAAAAATGTCTGTAAAGCATATTTACCTCTTGGGAGATAGGCACTATGTAAATAAGGTAAAATTTCTGTT ATTACAATTATTCATAATAATATTCTTTTCTTATTTCTAAGCCTTTCTGGGAAATCATTTCAGTCCACACCAACCATATTATTCAGGGTTCCTGCCATATGTGTGGGGTATCCTACTGATACACACGTATTCAAAGTTTATGGGTACAAC AAAGACATAGTACATGTACATAATATGTATGTGAATATAGTTAAATATATTTCTTCACAATATTTTAAACTGTGAAGAACTTTATCATACAGGAAACTTAAAACAAGAGGTGTCAAAAGACCCAAATTAGGTGCATTTTACTTGTTTATG ATGGCATAACCATTGCTTTAAAATGTTTAGACAGTAGAATATTGAATTTATGCTCTATTTTTGTTTATTTAAGCAACACTTAATGTAAAAGTGCAACAGGCAATTGAATCCAAATTTCAACGACAAAAAAAAAAAACATGTATTTTAGAG TTCATCTTTGGCAAAATCTTTGGTTCAGGGTACTAGTTGTTTAAAAGTTGATTCATATTCTTACCTTGTGCTGAGAAAGGTTGCATTGCTGCCCCTTATACACATGCTGCAGCTTGATGTTAAAGAATTTTTATTCTTTCTGAAGAACTA ATTAATGTTTAAAGCAACTGTTTAATATGATGGCATGTGTGTGTGTGCGTGCGTGTGTATGTTCTGAGTCCACTTCTTTTTTCCTAAATAACACTACAGGGATTTTGTCATATTAGATTTAATTTATAATTTGAAAAATCATCTAGTGTG TGACCTACAGGCTTAGAAATGGTATAGTCAAAGACATTTTATCCACATTTCTAATAGTGGACTTGATTAAGTAGATAAGATCAGCATCTGTTTATGGTAGTAGGAGAAATAGCCAAAGTTGAGGATTTTATGTATGTTTTCCTGTTTACC TGGAAAATAGCAATTAATTGGATTTTTTGGTAAAGATTGCCTTCTGTATAATGTTTGGATTATATAAAATTGCAAAAATGATAACAGCCCGCTTTACTGTACTAAGCCTGTTACTTTCATGACGTGTGAGCAGAATGCCTTATTTTGTAA TCTTGTTTAACTTGTTGCTACTGGGACTTGATTTACTGTGGCACTAGTTAAGTAAGTTAAAAAAAAGTTAAACCCTCTCATTATTAAAGAGGAAAGGCGATGGTGATGTCTGTAGTACAATATAAACCATAATTGTGATTTACCTTAAGT AGGTATAACTCTTATGGGATATACAGTATAGTTTTTGTGAATCTTTACATGATAGCATTATCTTTTTATAATTTTTTTTCCTAAGATAAACAAATGCATAGTTTTCTTCTATGGGTGATAGAAACAGCTTTTTGAAGTAATGAAAACCTC AAAAGATCATGTTGATTCTTAATTTTTGCCTTTTGCATAAGCCTCTTTATAACATGTATCTTTAAAACAATTAAGTCTTTAGGAATGTGTAACCAGAACTATGTTAGTATTGCTTATAAAACTTTAGTTAGGTTCAATATATACATATAT ACATCTCTATATAGGTATATAGATTTGCATTTTGTCTTGTAAAATTTTATTTGAATAAATTCTTCCTGTAGGTAATGGGAAACAAAATTAATAGTTCATATGTCACTCATAGCATTTCTATATTTGAAAGTAGCCCAATATAAAACTTTT GATTCTAAAATTAAACCAGCAGCCTATTACAAGCACATTCTTTGATTGAGTCATTGGTTATAAACTTACTAAATGCAGAGAAAGCAGCCAATTTAGGAAACTTCTGAGTTGGTGGGACACTGTTGATTAATAATGTACTGTATGAATTAA GTGATGCTTTAACTTTGATTTTACATTTTAAAGTTAAAATGTGGGCATTATGTCAGCAAACTTAAGGGCATTATGTCAGCAAGCTAAAACATTTTTTTTCCTGTGCTTTTAATGTATCTCTTTACATGATCTGAGAGAGGATTCAAGTTG ATAGAAATAGCTGAGGGGAAAAGGGGGAACATCTTGGGATGAAGCTTGTCCTTATGGTGATGGTTTAATTACAGATTAAAAAATTAGAAGGAAATTTCAGTGGATTAAGTGTATAGCTTTCATATCTACATTTCAAGAAATTACCATTGT AACTTGATAAGAGATGATTTATTTTATGTAAACATCTTTGCAAAGCAAGGTGTAGCAGCTCAGCTAGATTTATTACTGTGCACGAAAGTAAATACCTATCTCAATTATTCTTTTTCTTTTCCAATATAAAGTTTGCTGAATGTACAAGAA GAGTTTATCACTTAGGATATAGAATTTTTTTAGGGGTTGGGGGAGGGGATCTGTTAGGAAACTGTTACCTATAAACAAAGATTGACTGGATTCGATCCAAAAGATAAAACTTGAAGCTATTCTGGAACTAACATGGAAAAATGAAATGGC TATTGTTTAAAAAAATGATAGAAATACATTGTTGATGGGATATGAGTTAAGTTTATTTTCTACAAACTGTAATTGATGAGGACATGGATAATATCTTCATGTTTCTGAGAAGTAATCTGTATGTGGGGGGAGGGGATAATAAATATTTCT AACCAAC >DEK_NR1D2_ENST00000397239_ENST00000312521_18236682_24018713 length=4891nt Breakpoint=1495aa TCCGCGCTGCCAGGCCGCCTCGCCTCCCGCTCCCGCCCGCCCCGCGGGACACAGCCCGCCCGCACTCCGGGGCCCGAGCGCCGACCACACTCCAGGCGCAGCCGGGGAGAGCCCCGCGCGCGCATCCCTCCGCCCGCGGCCGAGGCGACC CCTCGCGGTCCCGCCCGCCCGAGCTTCCCGCGGAGGCACCCGGCCGCCCCGCCTCCCCCGCCCCGCGCCCGCCAACTCCCAGCTCGCGGCCCTGATTGGTCGCCGCATTCCCGCTCTCCTTCCCGAACCGCCATTTTGAAAATCTTGTTG ATTCTGGGGAGCCGAGCGCGCGGCGCGAGCGTCACGCCAGACAGCGGCCCGCGCGCCTTCTCCTCGGCGTCGGCCGCCGCCGCCTCCCAGAACCTCCTCGTGCCCTCGCGTGCCAGGCCCGCGGCGGCCGAAATCCGCGGTTCACAGCAT GTCCGCCTCGGCCCCTGCTGCGGAGGGGGAGGGAACCCCCACCCAGCCCGCGTCCGAGAAAGAACCCGAAATGCCCGGTCCCAGAGAGGAGAGCGAGGAGGAAGAGGACGAGGACGACGAGGAGGAGGAGGAGGAGGAAAAAGAAAAGAG TCTCATCGTGGAAGGCAAGAGGGAAAAGAAAAAAGTAGAGAGGTTGACAATGCAAGTCTCTTCCTTACAGAGAGAGCCATTTACAATTGCACAAGGAAAGGGGCAGAAACTTTGTGAAATTGAGAGGATACATTTTTTTCTAAGTAAGAA GAAAACCGATGAACTTAGAAATCTACACAAACTGCTTTACAACAGGCCAGGCACTGTGTCCTCATTAAAGAAGAATGTGGGTCAGTTCAGTGGCTTTCCATTTGAAAAAGGAAGTGTCCAATATAAAAAGAAGGAAGAAATGTTGAAAAA ATTTAGAAATGCCATGTTAAAGAGCATCTGTGAGGTTCTTGATTTGGAGAGATCAGGTGTAAATAGTGAACTAGTGAAGAGGATCTTGAATTTCTTAATGCATCCAAAGCCTTCTGGCAAACCATTGCCGAAATCTAAAAAAACTTGTAG CAAAGGCAGTAAAAAGGAACGGAACAGTTCTGGAATGGCAAGGAAGGCTAAGCGAACCAAATGTCCTGAAATTCTGTCAGATGAATCTAGTAGTGATGAAGATGAAAAGAAAAACAAGGAAGAGTCTTCAGATGATGAAGATAAAGAAAG TGAAGAGGAGCCACCAAAAAAGACAGCCAAAAGAGAAAAACCTAAACAGAAAGCTACTTCTAAAAGTAAAAAATCTGTGAAAAGTGCCAATGTTAAGAAAGCAGATAGCAGCACCACCAAGAAGAATCAAAACAGTTCCAAAAAAGAAAG TGAGTCTGAGGATAGTTCAGATGATGAACCTTTAATTAAAAAGTTGAAGAAACCCCCTACAGATGAAGAGTTAAAGGAAACAATAAAGAAATTACTGGCCAGTGCTAACTTGGAAGAAGTCACAATGAAACAGATTTGCAAAAAGATCGA TCTGGAATAGAAAACGTCAACTCTGTGGAGGCTTTGCAGGAAACTCTCATTCGTGCACTAAGGACCTTAATAATGAAAAACCATCCAAATGAGGCCTCTATTTTTACAAAACTGCTTCTAAAGTTGCCAGATCTTCGATCTTTAAACAAC ATGCACTCTGAGGAGCTCTTGGCCTTTAAAGTTCACCCTTAAGGCCTTTGTTTATTTAAACATGAACTGATGGTAACTGTACATTTTGTGCTAAAATGCATATTTATATGTGTATACCATATGTGGAGATAGAAAAGACCTTTAAGACAA TAAAAGATTGTAGGCTATCTCTGTAATCATGCAATAGCTGTTCGGATTGAGAACTCTTCAGCCATGATTAGACGTTGACTGCATCTCCCTGATAGACCAATCAGCTGTGTCGCACTTAAACTGGAGAAGTTACACTGAAGTATAATCACA CTGAATGTTAGACTTTTTCATCTGCCAAAACCAAAAACCATTTTGATCTCCCTGTGGTTATCAATATAACGCACAATCACAAGTGTATGAGGACTTAGAAATTAATCCTTTGTGGTAGGAGTTCTGTTGAATGATGGAAATCTTATTACT ACCACAAGACTATTTGATCTGGTAATTGGAGACTTCGGGATTTAGGAGATCTCCATGTCTGTATTTACTCTACCACTGCTAAAGTGTGTGGTCCTGGGTAGTTTACTTGCTTGCGGAAAATGAGAATTGATGGTGTCCCCAATGCCCCAC CTCACAGAGTTACTAAAAAATGTCTGTAAAGCATATTTACCTCTTGGGAGATAGGCACTATGTAAATAAGGTAAAATTTCTGTTATTACAATTATTCATAATAATATTCTTTTCTTATTTCTAAGCCTTTCTGGGAAATCATTTCAGTCC ACACCAACCATATTATTCAGGGTTCCTGCCATATGTGTGGGGTATCCTACTGATACACACGTATTCAAAGTTTATGGGTACAACAAAGACATAGTACATGTACATAATATGTATGTGAATATAGTTAAATATATTTCTTCACAATATTTT AAACTGTGAAGAACTTTATCATACAGGAAACTTAAAACAAGAGGTGTCAAAAGACCCAAATTAGGTGCATTTTACTTGTTTATGATGGCATAACCATTGCTTTAAAATGTTTAGACAGTAGAATATTGAATTTATGCTCTATTTTTGTTT ATTTAAGCAACACTTAATGTAAAAGTGCAACAGGCAATTGAATCCAAATTTCAACGACAAAAAAAAAAAACATGTATTTTAGAGTTCATCTTTGGCAAAATCTTTGGTTCAGGGTACTAGTTGTTTAAAAGTTGATTCATATTCTTACCT TGTGCTGAGAAAGGTTGCATTGCTGCCCCTTATACACATGCTGCAGCTTGATGTTAAAGAATTTTTATTCTTTCTGAAGAACTAATTAATGTTTAAAGCAACTGTTTAATATGATGGCATGTGTGTGTGTGCGTGCGTGTGTATGTTCTG AGTCCACTTCTTTTTTCCTAAATAACACTACAGGGATTTTGTCATATTAGATTTAATTTATAATTTGAAAAATCATCTAGTGTGTGACCTACAGGCTTAGAAATGGTATAGTCAAAGACATTTTATCCACATTTCTAATAGTGGACTTGA TTAAGTAGATAAGATCAGCATCTGTTTATGGTAGTAGGAGAAATAGCCAAAGTTGAGGATTTTATGTATGTTTTCCTGTTTACCTGGAAAATAGCAATTAATTGGATTTTTTGGTAAAGATTGCCTTCTGTATAATGTTTGGATTATATA AAATTGCAAAAATGATAACAGCCCGCTTTACTGTACTAAGCCTGTTACTTTCATGACGTGTGAGCAGAATGCCTTATTTTGTAATCTTGTTTAACTTGTTGCTACTGGGACTTGATTTACTGTGGCACTAGTTAAGTAAGTTAAAAAAAA GTTAAACCCTCTCATTATTAAAGAGGAAAGGCGATGGTGATGTCTGTAGTACAATATAAACCATAATTGTGATTTACCTTAAGTAGGTATAACTCTTATGGGATATACAGTATAGTTTTTGTGAATCTTTACATGATAGCATTATCTTTT TATAATTTTTTTTCCTAAGATAAACAAATGCATAGTTTTCTTCTATGGGTGATAGAAACAGCTTTTTGAAGTAATGAAAACCTCAAAAGATCATGTTGATTCTTAATTTTTGCCTTTTGCATAAGCCTCTTTATAACATGTATCTTTAAA ACAATTAAGTCTTTAGGAATGTGTAACCAGAACTATGTTAGTATTGCTTATAAAACTTTAGTTAGGTTCAATATATACATATATACATCTCTATATAGGTATATAGATTTGCATTTTGTCTTGTAAAATTTTATTTGAATAAATTCTTCC TGTAGGTAATGGGAAACAAAATTAATAGTTCATATGTCACTCATAGCATTTCTATATTTGAAAGTAGCCCAATATAAAACTTTTGATTCTAAAATTAAACCAGCAGCCTATTACAAGCACATTCTTTGATTGAGTCATTGGTTATAAACT TACTAAATGCAGAGAAAGCAGCCAATTTAGGAAACTTCTGAGTTGGTGGGACACTGTTGATTAATAATGTACTGTATGAATTAAGTGATGCTTTAACTTTGATTTTACATTTTAAAGTTAAAATGTGGGCATTATGTCAGCAAACTTAAG GGCATTATGTCAGCAAGCTAAAACATTTTTTTTCCTGTGCTTTTAATGTATCTCTTTACATGATCTGAGAGAGGATTCAAGTTGATAGAAATAGCTGAGGGGAAAAGGGGGAACATCTTGGGATGAAGCTTGTCCTTATGGTGATGGTTT AATTACAGATTAAAAAATTAGAAGGAAATTTCAGTGGATTAAGTGTATAGCTTTCATATCTACATTTCAAGAAATTACCATTGTAACTTGATAAGAGATGATTTATTTTATGTAAACATCTTTGCAAAGCAAGGTGTAGCAGCTCAGCTA GATTTATTACTGTGCACGAAAGTAAATACCTATCTCAATTATTCTTTTTCTTTTCCAATATAAAGTTTGCTGAATGTACAAGAAGAGTTTATCACTTAGGATATAGAATTTTTTTAGGGGTTGGGGGAGGGGATCTGTTAGGAAACTGTT ACCTATAAACAAAGATTGACTGGATTCGATCCAAAAGATAAAACTTGAAGCTATTCTGGAACTAACATGGAAAAATGAAATGGCTATTGTTTAAAAAAATGATAGAAATACATTGTTGATGGGATATGAGTTAAGTTTATTTTCTACAAA CTGTAATTGATGAGGACATGGATAATATCTTCATGTTTCTGAGAAGTAATCTGTATGTGGGGGGAGGGGATAATAAATATTTCTAACCAAC |
| N-Truncated Transcript (5UTR-3CDS) Sequences |
| C-Truncated Transcript (5CDS-3UTR) Sequences |
>DEK_NR1D2_ENST00000244776_ENST00000492552_18236682_24018713 length=1111nt Breakpoint=1111aa ATTTTGAAAATCTTGTTGATTCTGGGGAGCCGAGCGCGCGGCGCGAGCGTCACGCCAGACAGCGGCCCGCGCGCCTTCTCCTCGGCGTCGGCCGCCGCCGCCTCCCAGAACCTCCTCGTGCCCTCGCGTGCCAGGCCCGCGGCGGCCGAA ATCCGCGGTTCACAGCATGTCCGCCTCGGCCCCTGCTGCGGAGGGGGAGGGAACCCCCACCCAGCCCGCGTCCGAGAAAGAACCCGAAATGCCCGGTCCCAGAGAGGAGAGCGAGGAGGAAGAGGACGAGGACGACGAGGAGGAGGAGGA GGAGGAAAAAGGAAAGGGGCAGAAACTTTGTGAAATTGAGAGGATACATTTTTTTCTAAGTAAGAAGAAAACCGATGAACTTAGAAATCTACACAAACTGCTTTACAACAGGCCAGGCACTGTGTCCTCATTAAAGAAGAATGTGGGTCA GTTCAGTGGCTTTCCATTTGAAAAAGGAAGTGTCCAATATAAAAAGAAGGAAGAAATGTTGAAAAAATTTAGAAATGCCATGTTAAAGAGCATCTGTGAGGTTCTTGATTTGGAGAGATCAGGTGTAAATAGTGAACTAGTGAAGAGGAT CTTGAATTTCTTAATGCATCCAAAGCCTTCTGGCAAACCATTGCCGAAATCTAAAAAAACTTGTAGCAAAGGCAGTAAAAAGGAACGGAACAGTTCTGGAATGGCAAGGAAGGCTAAGCGAACCAAATGTCCTGAAATTCTGTCAGATGA ATCTAGTAGTGATGAAGATGAAAAGAAAAACAAGGAAGAGTCTTCAGATGATGAAGATAAAGAAAGTGAAGAGGAGCCACCAAAAAAGACAGCCAAAAGAGAAAAACCTAAACAGAAAGCTACTTCTAAAAGTAAAAAATCTGTGAAAAG TGCCAATGTTAAGAAAGCAGATAGCAGCACCACCAAGAAGAATCAAAACAGTTCCAAAAAAGAAAGTGAGTCTGAGGATAGTTCAGATGATGAACCTTTAATTAAAAAGTTGAAGAAACCCCCTACAGATGAAGAGTTAAAGGAAACAAT AAAGAAATTACTGGCCAGTGCTAACTTGGAAGAAGTCACAATGAAACAGATTTGCAAAAAG >DEK_NR1D2_ENST00000397239_ENST00000492552_18236682_24018713 length=1495nt Breakpoint=1495aa TCCGCGCTGCCAGGCCGCCTCGCCTCCCGCTCCCGCCCGCCCCGCGGGACACAGCCCGCCCGCACTCCGGGGCCCGAGCGCCGACCACACTCCAGGCGCAGCCGGGGAGAGCCCCGCGCGCGCATCCCTCCGCCCGCGGCCGAGGCGACC CCTCGCGGTCCCGCCCGCCCGAGCTTCCCGCGGAGGCACCCGGCCGCCCCGCCTCCCCCGCCCCGCGCCCGCCAACTCCCAGCTCGCGGCCCTGATTGGTCGCCGCATTCCCGCTCTCCTTCCCGAACCGCCATTTTGAAAATCTTGTTG ATTCTGGGGAGCCGAGCGCGCGGCGCGAGCGTCACGCCAGACAGCGGCCCGCGCGCCTTCTCCTCGGCGTCGGCCGCCGCCGCCTCCCAGAACCTCCTCGTGCCCTCGCGTGCCAGGCCCGCGGCGGCCGAAATCCGCGGTTCACAGCAT GTCCGCCTCGGCCCCTGCTGCGGAGGGGGAGGGAACCCCCACCCAGCCCGCGTCCGAGAAAGAACCCGAAATGCCCGGTCCCAGAGAGGAGAGCGAGGAGGAAGAGGACGAGGACGACGAGGAGGAGGAGGAGGAGGAAAAAGAAAAGAG TCTCATCGTGGAAGGCAAGAGGGAAAAGAAAAAAGTAGAGAGGTTGACAATGCAAGTCTCTTCCTTACAGAGAGAGCCATTTACAATTGCACAAGGAAAGGGGCAGAAACTTTGTGAAATTGAGAGGATACATTTTTTTCTAAGTAAGAA GAAAACCGATGAACTTAGAAATCTACACAAACTGCTTTACAACAGGCCAGGCACTGTGTCCTCATTAAAGAAGAATGTGGGTCAGTTCAGTGGCTTTCCATTTGAAAAAGGAAGTGTCCAATATAAAAAGAAGGAAGAAATGTTGAAAAA ATTTAGAAATGCCATGTTAAAGAGCATCTGTGAGGTTCTTGATTTGGAGAGATCAGGTGTAAATAGTGAACTAGTGAAGAGGATCTTGAATTTCTTAATGCATCCAAAGCCTTCTGGCAAACCATTGCCGAAATCTAAAAAAACTTGTAG CAAAGGCAGTAAAAAGGAACGGAACAGTTCTGGAATGGCAAGGAAGGCTAAGCGAACCAAATGTCCTGAAATTCTGTCAGATGAATCTAGTAGTGATGAAGATGAAAAGAAAAACAAGGAAGAGTCTTCAGATGATGAAGATAAAGAAAG TGAAGAGGAGCCACCAAAAAAGACAGCCAAAAGAGAAAAACCTAAACAGAAAGCTACTTCTAAAAGTAAAAAATCTGTGAAAAGTGCCAATGTTAAGAAAGCAGATAGCAGCACCACCAAGAAGAATCAAAACAGTTCCAAAAAAGAAAG TGAGTCTGAGGATAGTTCAGATGATGAACCTTTAATTAAAAAGTTGAAGAAACCCCCTACAGATGAAGAGTTAAAGGAAACAATAAAGAAATTACTGGCCAGTGCTAACTTGGAAGAAGTCACAATGAAACAGATTTGCAAAAAG |
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Fusion Protein Sequence for DEK_NR1D2 |
| In-frame Fusion Protein Sequences. |
>DEK_NR1D2_ENST00000244776_ENST00000312521_18236682_24018713 length=319aa MSASAPAAEGEGTPTQPASEKEPEMPGPREESEEEEDEDDEEEEEEEKGKGQKLCEIERIHFFLSKKKTDELRNLHKLLYNRPGTVSSLKKNVGQFSGFPFEKGSVQYKKKEEMLKKFRNAMLKSICEVLDLERSGVNSELVKRILNFLM HPKPSGKPLPKSKKTCSKGSKKERNSSGMARKAKRTKCPEILSDESSSDEDEKKNKEESSDDEDKESEEEPPKKTAKREKPKQKATSKSKKSVKSANVKKADSSTTKKNQNSSKKESESEDSSDDEPLIKKLKKPPTDEELKETIKKLLA SANLEEVTMKQICKKIDLE >DEK_NR1D2_ENST00000397239_ENST00000312521_18236682_24018713 length=353aa MSASAPAAEGEGTPTQPASEKEPEMPGPREESEEEEDEDDEEEEEEEKEKSLIVEGKREKKKVERLTMQVSSLQREPFTIAQGKGQKLCEIERIHFFLSKKKTDELRNLHKLLYNRPGTVSSLKKNVGQFSGFPFEKGSVQYKKKEEMLK KFRNAMLKSICEVLDLERSGVNSELVKRILNFLMHPKPSGKPLPKSKKTCSKGSKKERNSSGMARKAKRTKCPEILSDESSSDEDEKKNKEESSDDEDKESEEEPPKKTAKREKPKQKATSKSKKSVKSANVKKADSSTTKKNQNSSKKE SESEDSSDDEPLIKKLKKPPTDEELKETIKKLLASANLEEVTMKQICKKIDLE |
| N-Truncated Protein (5UTR-3CDS) Sequences |
| C-Truncated Protein (5CDS-3UTR) Sequences |
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Personalized Fusion Protein Sequence for DEK_NR1D2 |
| TCGA Kinase/DNA-binding Domain Mutated Fusion Protein Sequences |
| Num | Gene Group | Domain Loci | Fusion Protein ID | Fusion Gene Name | Partner | Mutated Residue in WT Protein | Seq. Length | Mutated Residue in Fusion Protein |
| CCLE Kinase/DNA-binding Domain Mutated Fusion Protein Sequences |
| Num | Gene Group | Domain Loci | Fusion Protein ID | Fusion Gene Name | Partner | Mutated Residue in WT Protein | Seq. Length | Mutated Residue in Fusion Protein |
| TCGA All Mutated Fusion Protein Sequences |
| Fusion Protein ID | Sample ID | Mutated Partner | AAchange in WT | Seq. Length | AAchange in Fusion |
| CCLE All Mutated Fusion Protein Sequences |
| Fusion Protein ID | Sample ID | Mutated Partner | AAchange in WT | Seq. Length | AAchange in Fusion |
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Fusion Gene Exprssed Samples for DEK_NR1D2 |
| RNA-seq based fusion gene expressed samples. |
| Source | Study | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | FusionScan | GSE122401 | DEK | chr6 | 18236682 | - | NR1D2 | chr3 | 24018713 | + |
| DNA-seq based fusion gene expressed samples. |
| Source | Study | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | SV type |
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Related Drugs for DEK_NR1D2 |
| PubMed Abstract Search With ['A-B' AND 'drug'], ['A::B' AND 'drug'] * For more details on the Studied, Reported, Approved Drugs targeting this fusion gene, Go to FusionPub. |
| PMID | Fusion Gene Name | Drug | Study Title |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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