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	Fusion Gene Summary
	Fusion Gene Breakpoints
	Tumorigenic MoA (Mechanism of Action) Scenarios of Fusion Geness
	Fusion Genomic Features
	Fusion Gene ORF Annotations
	Fusion Protein Retained/Non-Retained Functional Features
	Fusion Transcript Sequences
	Fusion Protein Sequences
	Personalized Fusion Protein Sequences
	Fusion Gene Expressed Samples
	Related Drugs

Fusion gene:AKIRIN1_MEAF6 (FusionGDB2 ID:HG79647TG64769)

Fusion Gene Summary for AKIRIN1_MEAF6

Fusion gene summary

Fusion gene information	Fusion gene name: AKIRIN1_MEAF6
	Fusion gene ID: hg79647tg64769
		Hgene	Tgene
	Gene symbol	AKIRIN1	MEAF6
	Gene ID	79647	64769
	Gene name	akirin 1	MYST/Esa1 associated factor 6
	Synonyms	C1orf108\|STRF2	C1orf149\|CENP-28\|EAF6\|NY-SAR-91
	Cytomap	1p34.3	1p34.3
	Type of gene	protein-coding	protein-coding
	Description	akirin-1	chromatin modification-related protein MEAF6Esa1p-associated factor 6 homologcentromere protein 28protein EAF6 homologsarcoma antigen NY-SAR-91
	Modification date	20240305	20240403
	UniProtAcc	.	.
	Ensembl transtripts involved in fusion gene	ENST00000432648, ENST00000446189, ENST00000372984,
Fusion gene scores	* DoF score	* DoF score (Degree of Frequency) = # partners X # break points X # disease types 2 X 3 X 2=12	* DoF score (Degree of Frequency) = # partners X # break points X # disease types 4 X 4 X 4=64
	# samples	4	7
	** MAII score	** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score10) log2(4/1210)=1.73696559416621 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0	** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score10) log2(7/6410)=0.129283016944966 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0
Context	PubMed: AKIRIN1 [Title/Abstract] AND MEAF6 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	AKIRIN1(39463983)-MEAF6(37967597), # samples:2

Fusion gene breakpoints across AKIRIN1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across MEAF6 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Breakpoints for AKIRIN1_MEAF6

RNA-seq based exon junction arranged fusion gene breakpoints from 8 resources (TCGA, CCLE, cBioPortal, GenBank, ChimerDB, ChimerKB, ChildHoodFusions, and GTEx). For the expressed sample information, go to Fusion Gene Sample section.

Hgene	Hchr	Hbp	Tgene	Tchr	Tbp
AKIRIN1	chr1	39463983	MEAF6	chr1	37967597
AKIRIN1	chr1	38998311	MEAF6	chr1	37501996

DNA-seq based exon junction arranged fusion gene breakpoints from dbVar. For the expressed sample information, go to Fusion Gene Sample section.

Hgene

Hchr

Hbp

Tgene

Tchr

Tbp

SV type

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Tumorigenic MoA (Mechanism of Action) Scenarios of Fusion Genes for AKIRIN1_MEAF6

To generate these tumorigenic scenario annotations, we implemented a deduction-first, retrieval-later computational framework. The pipeline first applies rule-guided reasoning across ten core mechanistic categories (M1–M10) derived from fusion gene biology to infer candidate mechanisms, tumorigenic scenarios, targeting points, and targeting backgrounds. To ensure empirical accountability, a governed Python workflow retrieves literature candidates via NCBI E-utilities and Europe PMC using tiered searches. Using JSON Schema-constrained LLM evidence judges (GPT-5.6 Luna and Terra), retrieved articles are evaluated for specificity and confidence without de novo PMID generation. This produces two distinct versions: a strict version restricted to high- or medium-confidence fusion-specific evidence, and an extended version incorporating broader gene-, pathway-, and contextual evidence.

* We have 10 tumorigenic mechanism categories of fusion genes as shown below.

Constitutively Active Kinases, Catalytic Domain Dysregulation, & Transmembrane Ligand Fusions	Aberrant Chimeric Transcription Factor / Fusion Transcription Factor Activity	Epigenetic Reprogramming / Histone Modifier Dysregulation	Chromatin Remodeling Dysregulation	Condensate-Driven Transcriptional Rewiring / LLP	Promoter / Enhancer Hijacking	Dominant-Negative Antagonism	Cell Cycle / Checkpoint Bypass / RNA Processing Dysregulation	Subcellular Mislocalization / Spatial Dysregulation	Nuclear Body / Sub-organellar Architecture Disruption & Differentiation Blockade

* Strict version: Restricted to high- or medium-confidence fusion-specific evidence.

Fusion Gene Name	Mechanism Category	Mechanism PubMed	Tumorigenic Scenarios	Tumorigenic Scenario PubMed	Targeting Points	Targeting PubMed	Mechanism Background	Mechanism Background PubMed
AKIRIN1-MEAF6	Epigenetic Reprogramming / Histone Modifier Dysregulation M3		Fusion couples Akirin-1 to NuA4/Tip60 and MOZ/MORF histone acetyltransferase complexes, dysregulating H4 acetylation.		Histone acetyltransferase inhibitors; HDAC inhibitors		Mesenchymal and epithelial neoplasms

* Extended version: Includes all strict-level fusion evidence plus broader gene-, pathway-, and low-confidence contextual evidence.

Fusion Gene Name	Mechanism Category	Mechanism PubMed	Tumorigenic Scenarios	Tumorigenic Scenario PubMed	Targeting Points	Targeting PubMed	Mechanism Background	Mechanism Background PubMed
AKIRIN1-MEAF6	Epigenetic Reprogramming / Histone Modifier Dysregulation M3	Evidence level: Indirect gene evidence; Confidence: Medium; PMID: 24530230; Title: MEAF6/PHF1 is a recurrent gene fusion in endometrial stromal sarcoma.	Fusion couples Akirin-1 to NuA4/Tip60 and MOZ/MORF histone acetyltransferase complexes, dysregulating H4 acetylation.		Histone acetyltransferase inhibitors; HDAC inhibitors		Mesenchymal and epithelial neoplasms	Evidence level: Limited indirect gene evidence; Confidence: Low; PMID: 24285434; Title: Novel ZC3H7B-BCOR, MEAF6-PHF1, and EPC1-PHF1 fusions in ossifying fibromyxoid tumors--molecular characterization shows genetic overlap with endometrial stromal sarcoma.; PMID: 29275929; Title: Endometrial stromal sarcomas and related neoplasms: new developments and diagnostic considerations.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	MEAF6	GO:0001558	regulation of cell growth	22144582
Tgene	MEAF6	GO:0006275	regulation of DNA replication	16387653
Tgene	MEAF6	GO:0006355	regulation of DNA-templated transcription	18794358\|22144582
Tgene	MEAF6	GO:0051726	regulation of cell cycle	16387653
Tgene	MEAF6	GO:1905168	positive regulation of double-strand break repair via homologous recombination	27153538
Tgene	MEAF6	GO:2000278	regulation of DNA biosynthetic process	16387653

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Fusion Genomic Features for AKIRIN1_MEAF6

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence) of In-frame fusion genes. FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
AKIRIN1	chr1	39463983	+	MEAF6	chr1	37967597	-	1.42e-09	1.00e+00
AKIRIN1	chr1	39463983	-	MEAF6	chr1	37967597	-	4.67e-09	1.00e+00

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence) of 5UTR-3CSD fusion genes (N-truncated cases).

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence) of 5CDS-3UTR fusion genes (C-truncated cases).

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of six genomic regulatory feature tracks across a ±5 kb window centered on the fusion breakpoints. We input the breakpoint sequences into AlphaGenome and obtained predicted genome tracks at single-base-pair resolution for each modality by running a single forward pass over the reference sequence. Specifically, for each breakpoint, AlphaGenome processed and returned predicted track data across diverse modalities, which were then averaged across all tracks within each output type and visualized across the ±5 kb window. The left panel shows the 5'-gene breakpoint ±5 kb area, and the right panel shows the 3'-gene breakpoint area, with tracks grouped by category: chromatin accessibility (DNase-seq, ATAC-seq), active transcription (RNA-seq, CAGE), and chromatin binding (ChIP-Histone, ChIP-TF).

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Fusion Gene ORF Annotations for AKIRIN1_MEAF6

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-5UTR	ENST00000432648	ENST00000373073	AKIRIN1	chr1	39463983	-	MEAF6	chr1	37967597	-
5CDS-5UTR	ENST00000432648	ENST00000448519	AKIRIN1	chr1	39463983	-	MEAF6	chr1	37967597	-
5CDS-5UTR	ENST00000432648	ENST00000475828	AKIRIN1	chr1	39463983	-	MEAF6	chr1	37967597	-
5CDS-5UTR	ENST00000446189	ENST00000373073	AKIRIN1	chr1	39463983	-	MEAF6	chr1	37967597	-
5CDS-5UTR	ENST00000446189	ENST00000448519	AKIRIN1	chr1	39463983	-	MEAF6	chr1	37967597	-
5CDS-5UTR	ENST00000446189	ENST00000475828	AKIRIN1	chr1	39463983	-	MEAF6	chr1	37967597	-
In-frame	ENST00000432648	ENST00000296214	AKIRIN1	chr1	39463983	-	MEAF6	chr1	37967597	-
In-frame	ENST00000432648	ENST00000373074	AKIRIN1	chr1	39463983	-	MEAF6	chr1	37967597	-
In-frame	ENST00000432648	ENST00000373075	AKIRIN1	chr1	39463983	-	MEAF6	chr1	37967597	-
In-frame	ENST00000446189	ENST00000296214	AKIRIN1	chr1	39463983	-	MEAF6	chr1	37967597	-
In-frame	ENST00000446189	ENST00000373074	AKIRIN1	chr1	39463983	-	MEAF6	chr1	37967597	-
In-frame	ENST00000446189	ENST00000373075	AKIRIN1	chr1	39463983	-	MEAF6	chr1	37967597	-

ORFfinder Result Based On The Fusion Transcript Sequences of the In-frame Fusion Genes.

Henst	Tenst	Hgene	Hchr	Hbp	Tgene	Tchr	Tbp	Seq length (transcript)	Seq length (peptide)
ENST00000432648	ENST00000296214	AKIRIN1	chr1	39463983	MEAF6	chr1	37967597	519	208
ENST00000432648	ENST00000373074	AKIRIN1	chr1	39463983	MEAF6	chr1	37967597	519	198
ENST00000432648	ENST00000373075	AKIRIN1	chr1	39463983	MEAF6	chr1	37967597	519	3014
ENST00000446189	ENST00000296214	AKIRIN1	chr1	39463983	MEAF6	chr1	37967597	454	208
ENST00000446189	ENST00000373074	AKIRIN1	chr1	39463983	MEAF6	chr1	37967597	454	198
ENST00000446189	ENST00000373075	AKIRIN1	chr1	39463983	MEAF6	chr1	37967597	454	198

ORFfinder Result Based On The Fusion Transcript Sequences of the 5UTR-3CDS Fusion Genes for N-Truncated Protein Search.

Henst

Tenst

Hgene

Hchr

Hbp

Tgene

Tchr

Tbp

Seq length
(transcript)

Seq length
(peptide)

ORFfinder Result Based On The Fusion Transcript Sequences of the 5CDS-3UTR Fusion Genes for C-Truncated Protein Search.

Henst

Tenst

Hgene

Hchr

Hbp

Tgene

Tchr

Tbp

Seq length
(transcript)

Seq length
(peptide)

DeepORF Prediction of The Coding Potential Based on The Fusion Transcript Sequence of In-frame Fusion Genes. DeepORF is a Coding Potential Classifier Based on Convolutional Neural Network by Comparing the Real Ribo-seq Data. If the No-coding Score < 0.5 and Coding Score > 0.5, Then The In-frame Fusion Transcript is Predicted as Being Likely Translated.

Henst	Tenst	Hgene	Hchr	Hbp	Tgene	Tchr	Tbp	No-coding score	Coding score
ENST00000432648	ENST00000296214	AKIRIN1	chr1	39463983	MEAF6	chr1	37967597	2.96e-02	9.70e-01
ENST00000432648	ENST00000373074	AKIRIN1	chr1	39463983	MEAF6	chr1	37967597	3.20e-02	9.68e-01
ENST00000432648	ENST00000373075	AKIRIN1	chr1	39463983	MEAF6	chr1	37967597	2.43e-02	9.76e-01
ENST00000446189	ENST00000296214	AKIRIN1	chr1	39463983	MEAF6	chr1	37967597	3.33e-02	9.67e-01
ENST00000446189	ENST00000373074	AKIRIN1	chr1	39463983	MEAF6	chr1	37967597	3.71e-02	9.63e-01
ENST00000446189	ENST00000373075	AKIRIN1	chr1	39463983	MEAF6	chr1	37967597	2.60e-02	9.74e-01

DeepORF Prediction of The Coding Potential Based on The Fusion Transcript Sequence of 5UTR-3CDS Fusion Genes (Potential N-Truncated Proteins).

Henst

Tenst

Hgene

Hchr

Hbp

Tgene

Tchr

Tbp

No-coding score

Coding score

DeepORF Prediction of The Coding Potential Based on The Fusion Transcript Sequence of 5CDS-3UTR Fusion Genes (Potential C-Truncated Proteins).

Henst

Tenst

Hgene

Hchr

Hbp

Tgene

Tchr

Tbp

No-coding score

Coding score

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Fusion Protein Retained/Non-Retained Functional Features for AKIRIN1_MEAF6

Protein Level Annotation from FGviewer
* Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at download page. Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features (visualization across fusion protein length).

AKIRIN1_MEAF6_chr1-39463983_chr1-37967597.png

- In-frame and retained protein feature among the 13 regional features (texts).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

AKIRIN1

chr1:39463983

chr1:37967597

ENST00000432648

Q9H9L7

104_122

120.33333333333333

193.0

Compositional bias

Polar residues

Hgene

AKIRIN1

chr1:39463983

chr1:37967597

ENST00000432648

Q9H9L7

31_49

120.33333333333333

193.0

Compositional bias

Pro residues

Hgene

AKIRIN1

chr1:39463983

chr1:37967597

ENST00000432648

Q9H9L7

50_60

120.33333333333333

193.0

Compositional bias

Low complexity

Hgene

AKIRIN1

chr1:39463983

chr1:37967597

ENST00000432648

Q9H9L7

23_28

120.33333333333333

193.0

Motif

Note=Nuclear localization signal

Hgene

AKIRIN1

chr1:39463983

chr1:37967597

ENST00000432648

Q9H9L7

17_71

120.33333333333333

193.0

Region

Disordered

Tgene

MEAF6

chr1:39463983

chr1:37967597

ENST00000296214

Q9HAF1

119_128

113.33333333333333

192.0

Compositional bias

Polar residues

Tgene

MEAF6

chr1:39463983

chr1:37967597

ENST00000296214

Q9HAF1

135_144

113.33333333333333

192.0

Compositional bias

Acidic residues

Tgene

MEAF6

chr1:39463983

chr1:37967597

ENST00000296214

Q9HAF1

165_177

113.33333333333333

192.0

Compositional bias

Basic residues

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

AKIRIN1

chr1:39463983

chr1:37967597

ENST00000432648

Q9H9L7

189_192

120.33333333333333

193.0

Motif

SYVS motif

Hgene

AKIRIN1

chr1:39463983

chr1:37967597

ENST00000432648

Q9H9L7

104_127

120.33333333333333

193.0

Region

Disordered

Tgene

MEAF6

chr1:39463983

chr1:37967597

ENST00000296214

Q9HAF1

11_47

113.33333333333333

192.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

MEAF6

chr1:39463983

chr1:37967597

ENST00000296214

Q9HAF1

104_191

113.33333333333333

192.0

Region

Disordered

- Retained PPIs in in-frame fusion.

Partner

Hgene

Hbp

Tgene

Tbp

ENST

UniProt

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Hgene

Hbp

Tgene

Tbp

ENST

UniProt

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Fusion Transcript Sequence for AKIRIN1_MEAF6

In-frame Fusion Transcript Sequences.

>AKIRIN1_MEAF6_ENST00000432648_ENST00000296214_39463983_37967597 length=1676nt 
 Breakpoint=519nt
GATGGTGTGCGCCCGTGACGTCACAGAAGGCGGGGCCAGCGCCGCTGCCGGGTGCTGGAGGCGCCATTGGAGCCGGCTTGGCTGGCGAGCCCGGCTGAGGAGCCTCTTGGGCCGCACTTACCGCCGCGTCCGCTCCCGGTCCCTGGCCCC
TCAGCGGCATGGCGTGCGGGGCGACGCTGAAGCGGCCCATGGAGTTCGAGGCGGCGCTGCTGAGCCCCGGCTCCCCGAAGCGGCGGCGCTGCGCCCCTCTGCCCGGCCCCACTCCGGGCCTCAGGCCCCCGGACGCCGAGCCGCCGCCGC
CGTTTCAGACGCAGACCCCACCGCAGAGTCTGCAGCAGCCCGCCCCGCCCGGCAGCGAGCGGCGCCTTCCAACTCCGGAGCAAATTTTTCAGAACATAAAACAAGAATATAGTCGTTATCAGAGGTGGAGACATTTAGAAGTTGTTCTTA
ATCAGAGTGAAGCTTGTGCTTCGGAAAGTCAACCTCACTCCTCAGCACTCACAGCACCTAGCTCTCCAGGGGAGCCAGGAAGTGGGACGGAAAGTGACACTTCTCCAGACTTCCACAATCAGGAAAATGAGCCCAGCCAGGAGGACCCTG
AGGATCTGGATGGATCTGTGCAGGGAGTGAAACCTCAGAAGGCTGCTTCTTCTACTTCCTCAGGGAGTCACCACAGCAGCCATAAAAAGCGAAAGAATAAAAACCGGCACAGGATTGATCTGAAGTTAAACAAAAAACCACGAGCTGACT
ATTAGAAGACACATTAGTGCAGAAGCTTCCAGGCTGTAGAGCCCTGCTTCCCTTCTCTGACCTCACAAAGATAAACATCCTTCACCTGAGTTCGTGGCCATCCACCTCTGCTCTCCCAGACCCAGTGCCTGTGACTTTGAGTAGTTTGTT
CTAAATGTGGTGACAAACAAGTCATTTCTGTAAGACATTGGGTCTTACTTTATGTCATTTTTAGTAACAGAACTGCAGGAAGATGAAGACAATGTTGTAATCCCAGCAAGTTGCTAACTGTGCGTTTCTCCCTTCTTAGAATGAATGTCT
CCCCCAAAACTGGCTGGCACCAGCTTCATCTGTGATACCCTTCAAGAAATGTTCTCTGGTTTTGTTTTATGCTGAAAGTAGAACACAAGTCACATTTCAGATGGAGGCTGTAAATATCTGGCATTTTCTTATATTGTTTTATGTTTTCTT
GTTTTTCTCTTGTTGTTTTTATCTTATTTTCTTTGGGGTTTTTTTGTAATGCCTTTGTACAGCTCATACTTTCCTGCTGACATATCTGATCATCTCTTTCATGCAGTTGCCAATATTCATAACTGAAAATAATCTGGTTTATCATAAGTA
AAATGGGAAACTTGCCTCTGTTTTTTGCAAGGGGAGGTAAAGAGTGTTTAGTAATTACCTATCTTAAATCTTTCTGAGTTGGTAGTAGATTCATGTTCAAGGAACAGGAAAAATGGAAAAACATAAGTTTAAATCAGTTCTTTTTAAATA
ACTTTTTATTCTTTTGTATAAATAAAATTTCACAGGCTTCAAATTCTCATGCTTTACTTTTAAACCCGAGATTGTTTTTTCACTTATTTATTCATATCATGCCTTATGGAAATTTCTTTTTCTGTATTTTCTCTCTTTGCTGGTATTCAC
CTGATTAAATATTGCTCTAAAAATCA

>AKIRIN1_MEAF6_ENST00000432648_ENST00000373074_39463983_37967597 length=1543nt 
 Breakpoint=519nt
GATGGTGTGCGCCCGTGACGTCACAGAAGGCGGGGCCAGCGCCGCTGCCGGGTGCTGGAGGCGCCATTGGAGCCGGCTTGGCTGGCGAGCCCGGCTGAGGAGCCTCTTGGGCCGCACTTACCGCCGCGTCCGCTCCCGGTCCCTGGCCCC
TCAGCGGCATGGCGTGCGGGGCGACGCTGAAGCGGCCCATGGAGTTCGAGGCGGCGCTGCTGAGCCCCGGCTCCCCGAAGCGGCGGCGCTGCGCCCCTCTGCCCGGCCCCACTCCGGGCCTCAGGCCCCCGGACGCCGAGCCGCCGCCGC
CGTTTCAGACGCAGACCCCACCGCAGAGTCTGCAGCAGCCCGCCCCGCCCGGCAGCGAGCGGCGCCTTCCAACTCCGGAGCAAATTTTTCAGAACATAAAACAAGAATATAGTCGTTATCAGAGGTGGAGACATTTAGAAGTTGTTCTTA
ATCAGAGTGAAGCTTGTGCTTCGGAAAGTCAACCTCACTCCTCAGCACTCACAGCACCTAGCTCTCCAGGGGAGCCAGGAAGTGGGACGGAAAGTGACACTTCTCCAGACTTCCACAATCAGGAAAATGAGCCCAGCCAGGAGGACCCTG
AGGATCTGGATGGATCTGTGCAGGGAGTGAAACCTCAGAAGGCTGCTTCTTCTACTTCCTCAGGGAGTCACCACAGCAGCCATAAAAAGCGAAAGAATAAAAACCGGCACAGGATTGATCTGAAGTTAAACAAAAAACCACGAGCTGACT
ATTAGAAGACACATTAGTGCAGAAGCTTCCAGGCTGTAGAGCCCTGCTTCCCTTCTCTGACCTCACAAAGATAAACATCCTTCACCTGAGTTCGTGGCCATCCACCTCTGCTCTCCCAGACCCAGTGCCTGTGACTTTGAGTAGTTTGTT
CTAAATGTGGTGACAAACAAGTCATTTCTGTAAGACATTGGGTCTTACTTTATGTCATTTTTAGTAACAGAACTGCAGGAAGATGAAGACAATGTTGTAATCCCAGCAAGTTGCTAACTGTGCGTTTCTCCCTTCTTAGAATGAATGTCT
CCCCCAAAACTGGCTGGCACCAGCTTCATCTGTGATACCCTTCAAGAAATGTTCTCTGGTTTTGTTTTATGCTGAAAGTAGAACACAAGTCACATTTCAGATGGAGGCTGTAAATATCTGGCATTTTCTTATATTGTTTTATGTTTTCTT
GTTTTTCTCTTGTTGTTTTTATCTTATTTTCTTTGGGGTTTTTTTGTAATGCCTTTGTACAGCTCATACTTTCCTGCTGACATATCTGATCATCTCTTTCATGCAGTTGCCAATATTCATAACTGAAAATAATCTGGTTTATCATAAGTA
AAATGGGAAACTTGCCTCTGTTTTTTGCAAGGGGAGGTAAAGAGTGTTTAGTAATTACCTATCTTAAATCTTTCTGAGTTGGTAGTAGATTCATGTTCAAGGAACAGGAAAAATGGAAAAACATAAGTTTAAATCAGTTCTTTTTAAATA
ACTTTTTATTCTTTTGTATAAATAAAATTTCACAGGCTTCAAA

>AKIRIN1_MEAF6_ENST00000432648_ENST00000373075_39463983_37967597 length=2309nt 
 Breakpoint=519nt
GATGGTGTGCGCCCGTGACGTCACAGAAGGCGGGGCCAGCGCCGCTGCCGGGTGCTGGAGGCGCCATTGGAGCCGGCTTGGCTGGCGAGCCCGGCTGAGGAGCCTCTTGGGCCGCACTTACCGCCGCGTCCGCTCCCGGTCCCTGGCCCC
TCAGCGGCATGGCGTGCGGGGCGACGCTGAAGCGGCCCATGGAGTTCGAGGCGGCGCTGCTGAGCCCCGGCTCCCCGAAGCGGCGGCGCTGCGCCCCTCTGCCCGGCCCCACTCCGGGCCTCAGGCCCCCGGACGCCGAGCCGCCGCCGC
CGTTTCAGACGCAGACCCCACCGCAGAGTCTGCAGCAGCCCGCCCCGCCCGGCAGCGAGCGGCGCCTTCCAACTCCGGAGCAAATTTTTCAGAACATAAAACAAGAATATAGTCGTTATCAGAGGTGGAGACATTTAGAAGTTGTTCTTA
ATCAGAGTGAAGCTTGTGCTTCGGAAAGTCAACCTCACTCCTCAGCACTCACAGCACCTAGCTCTCCAGGGGAGCCAGGAAGTGGGACGGAAAGTGACACTTCTCCAGACTTCCACAATCAGGAAAATGAGCCCAGCCAGGAGGACCCTG
AGGATCTGGATGGATCTGTGCAGGGAGTGAAACCTCAGAAGGCTGCTTCTTCTACTTCCTCAGGGAGTCACCACAGCAGCCATAAAAAGCGAAAGAATAAAAACCGGCACAGCCCGTCTGGCATGTTTGATTATGACTTTGAGATTGATC
TGAAGTTAAACAAAAAACCACGAGCTGACTATTAGAAGACACATTAGTGCAGAAGCTTCCAGGCTGTAGAGCCCTGCTTCCCTTCTCTGACCTCACAAAGATAAACATCCTTCACCTGAGTTCGTGGCCATCCACCTCTGCTCTCCCAGA
CCCAGTGCCTGTGACTTTGAGTAGTTTGTTCTAAATGTGGTGACAAACAAGTCATTTCTGTAAGACATTGGGTCTTACTTTATGTCATTTTTAGTAACAGAACTGCAGGAAGATGAAGACAATGTTGTAATCCCAGCAAGTTGCTAACTG
TGCGTTTCTCCCTTCTTAGAATGAATGTCTCCCCCAAAACTGGCTGGCACCAGCTTCATCTGTGATACCCTTCAAGAAATGTTCTCTGGTTTTGTTTTATGCTGAAAGTAGAACACAAGTCACATTTCAGATGGAGGCTGTAAATATCTG
GCATTTTCTTATATTGTTTTATGTTTTCTTGTTTTTCTCTTGTTGTTTTTATCTTATTTTCTTTGGGGTTTTTTTGTAATGCCTTTGTACAGCTCATACTTTCCTGCTGACATATCTGATCATCTCTTTCATGCAGTTGCCAATATTCAT
AACTGAAAATAATCTGGTTTATCATAAGTAAAATGGGAAACTTGCCTCTGTTTTTTGCAAGGGGAGGTAAAGAGTGTTTAGTAATTACCTATCTTAAATCTTTCTGAGTTGGTAGTAGATTCATGTTCAAGGAACAGGAAAAATGGAAAA
ACATAAGTTTAAATCAGTTCTTTTTAAATAACTTTTTATTCTTTTGTATAAATAAAATTTCACAGGCTTCAAATTCTCATGCTTTACTTTTAAACCCGAGATTGTTTTTTCACTTATTTATTCATATCATGCCTTATGGAAATTTCTTTT
TCTGTATTTTCTCTCTTTGCTGGTATTCACCTGATTAAATATTGCTCTAAAAATCACCATGGCATATGGAAAGTCTCAAAATTATACCAAAAGTGATAACTTATGTCGTTCTTAAGTGGAGTGAAAGGATAGCATCAGTGAGAGCCAGTG
TTGCCCACCAGGTCTCCCTTTCTTGGAGGGCTTGTTGGGGCTGAGGAATCTGCTAGTAATCGTTACCTGCCTCTAGTGCTGTGGTGAACTTGCGACAGGGTCTGGCTGCACATTGGAATCACCTGAGAAGCTTTAAAATACTCATGCCTG
GATCCCATCCCTAGAGACTGGGGTACAGCCTAGTTATTGGGAATTTCTTTAAAAGAGTTCCTGGGATTCTGATAAGAAGCCAGGTTGAGAACCACTACATTAGAAGACTGAATGGTTTAATTTACATCCTATGTTATGATTGGTCTAAGG
GATAAGATTTGGGGTCTAACCTTTCCTTTCACTCTAGTTAGTCATAGTCCTTGACTTATGCCTATATCTTTGTAAGAAATAGTATGTTTCATTTGTGATAGTATTGGTAGGGCTGAATATGGATGGCATCTACTGTAAAACAAGTCTACC
TTGTCAGATGTGCAAAAGCTTTCACTCTTGTTCTCAAATAAACTTTTGTGGGTTTTTTT

>AKIRIN1_MEAF6_ENST00000446189_ENST00000296214_39463983_37967597 length=1611nt 
 Breakpoint=454nt
ATTGGAGCCGGCTTGGCTGGCGAGCCCGGCTGAGGAGCCTCTTGGGCCGCACTTACCGCCGCGTCCGCTCCCGGTCCCTGGCCCCTCAGCGGCATGGCGTGCGGGGCGACGCTGAAGCGGCCCATGGAGTTCGAGGCGGCGCTGCTGAGC
CCCGGCTCCCCGAAGCGGCGGCGCTGCGCCCCTCTGCCCGGCCCCACTCCGGGCCTCAGGCCCCCGGACGCCGAGCCGCCGCCGCCGTTTCAGACGCAGACCCCACCGCAGAGTCTGCAGCAGCCCGCCCCGCCCGGCAGCGAGCGGCGC
CTTCCAACTCCGGAGCAAATTTTTCAGAACATAAAACAAGAATATAGTCGTTATCAGAGGTGGAGACATTTAGAAGTTGTTCTTAATCAGAGTGAAGCTTGTGCTTCGGAAAGTCAACCTCACTCCTCAGCACTCACAGCACCTAGCTCT
CCAGGGGAGCCAGGAAGTGGGACGGAAAGTGACACTTCTCCAGACTTCCACAATCAGGAAAATGAGCCCAGCCAGGAGGACCCTGAGGATCTGGATGGATCTGTGCAGGGAGTGAAACCTCAGAAGGCTGCTTCTTCTACTTCCTCAGGG
AGTCACCACAGCAGCCATAAAAAGCGAAAGAATAAAAACCGGCACAGGATTGATCTGAAGTTAAACAAAAAACCACGAGCTGACTATTAGAAGACACATTAGTGCAGAAGCTTCCAGGCTGTAGAGCCCTGCTTCCCTTCTCTGACCTCA
CAAAGATAAACATCCTTCACCTGAGTTCGTGGCCATCCACCTCTGCTCTCCCAGACCCAGTGCCTGTGACTTTGAGTAGTTTGTTCTAAATGTGGTGACAAACAAGTCATTTCTGTAAGACATTGGGTCTTACTTTATGTCATTTTTAGT
AACAGAACTGCAGGAAGATGAAGACAATGTTGTAATCCCAGCAAGTTGCTAACTGTGCGTTTCTCCCTTCTTAGAATGAATGTCTCCCCCAAAACTGGCTGGCACCAGCTTCATCTGTGATACCCTTCAAGAAATGTTCTCTGGTTTTGT
TTTATGCTGAAAGTAGAACACAAGTCACATTTCAGATGGAGGCTGTAAATATCTGGCATTTTCTTATATTGTTTTATGTTTTCTTGTTTTTCTCTTGTTGTTTTTATCTTATTTTCTTTGGGGTTTTTTTGTAATGCCTTTGTACAGCTC
ATACTTTCCTGCTGACATATCTGATCATCTCTTTCATGCAGTTGCCAATATTCATAACTGAAAATAATCTGGTTTATCATAAGTAAAATGGGAAACTTGCCTCTGTTTTTTGCAAGGGGAGGTAAAGAGTGTTTAGTAATTACCTATCTT
AAATCTTTCTGAGTTGGTAGTAGATTCATGTTCAAGGAACAGGAAAAATGGAAAAACATAAGTTTAAATCAGTTCTTTTTAAATAACTTTTTATTCTTTTGTATAAATAAAATTTCACAGGCTTCAAATTCTCATGCTTTACTTTTAAAC
CCGAGATTGTTTTTTCACTTATTTATTCATATCATGCCTTATGGAAATTTCTTTTTCTGTATTTTCTCTCTTTGCTGGTATTCACCTGATTAAATATTGCTCTAAAAATCA

>AKIRIN1_MEAF6_ENST00000446189_ENST00000373074_39463983_37967597 length=1478nt 
 Breakpoint=454nt
ATTGGAGCCGGCTTGGCTGGCGAGCCCGGCTGAGGAGCCTCTTGGGCCGCACTTACCGCCGCGTCCGCTCCCGGTCCCTGGCCCCTCAGCGGCATGGCGTGCGGGGCGACGCTGAAGCGGCCCATGGAGTTCGAGGCGGCGCTGCTGAGC
CCCGGCTCCCCGAAGCGGCGGCGCTGCGCCCCTCTGCCCGGCCCCACTCCGGGCCTCAGGCCCCCGGACGCCGAGCCGCCGCCGCCGTTTCAGACGCAGACCCCACCGCAGAGTCTGCAGCAGCCCGCCCCGCCCGGCAGCGAGCGGCGC
CTTCCAACTCCGGAGCAAATTTTTCAGAACATAAAACAAGAATATAGTCGTTATCAGAGGTGGAGACATTTAGAAGTTGTTCTTAATCAGAGTGAAGCTTGTGCTTCGGAAAGTCAACCTCACTCCTCAGCACTCACAGCACCTAGCTCT
CCAGGGGAGCCAGGAAGTGGGACGGAAAGTGACACTTCTCCAGACTTCCACAATCAGGAAAATGAGCCCAGCCAGGAGGACCCTGAGGATCTGGATGGATCTGTGCAGGGAGTGAAACCTCAGAAGGCTGCTTCTTCTACTTCCTCAGGG
AGTCACCACAGCAGCCATAAAAAGCGAAAGAATAAAAACCGGCACAGGATTGATCTGAAGTTAAACAAAAAACCACGAGCTGACTATTAGAAGACACATTAGTGCAGAAGCTTCCAGGCTGTAGAGCCCTGCTTCCCTTCTCTGACCTCA
CAAAGATAAACATCCTTCACCTGAGTTCGTGGCCATCCACCTCTGCTCTCCCAGACCCAGTGCCTGTGACTTTGAGTAGTTTGTTCTAAATGTGGTGACAAACAAGTCATTTCTGTAAGACATTGGGTCTTACTTTATGTCATTTTTAGT
AACAGAACTGCAGGAAGATGAAGACAATGTTGTAATCCCAGCAAGTTGCTAACTGTGCGTTTCTCCCTTCTTAGAATGAATGTCTCCCCCAAAACTGGCTGGCACCAGCTTCATCTGTGATACCCTTCAAGAAATGTTCTCTGGTTTTGT
TTTATGCTGAAAGTAGAACACAAGTCACATTTCAGATGGAGGCTGTAAATATCTGGCATTTTCTTATATTGTTTTATGTTTTCTTGTTTTTCTCTTGTTGTTTTTATCTTATTTTCTTTGGGGTTTTTTTGTAATGCCTTTGTACAGCTC
ATACTTTCCTGCTGACATATCTGATCATCTCTTTCATGCAGTTGCCAATATTCATAACTGAAAATAATCTGGTTTATCATAAGTAAAATGGGAAACTTGCCTCTGTTTTTTGCAAGGGGAGGTAAAGAGTGTTTAGTAATTACCTATCTT
AAATCTTTCTGAGTTGGTAGTAGATTCATGTTCAAGGAACAGGAAAAATGGAAAAACATAAGTTTAAATCAGTTCTTTTTAAATAACTTTTTATTCTTTTGTATAAATAAAATTTCACAGGCTTCAAA

>AKIRIN1_MEAF6_ENST00000446189_ENST00000373075_39463983_37967597 length=2244nt 
 Breakpoint=454nt
ATTGGAGCCGGCTTGGCTGGCGAGCCCGGCTGAGGAGCCTCTTGGGCCGCACTTACCGCCGCGTCCGCTCCCGGTCCCTGGCCCCTCAGCGGCATGGCGTGCGGGGCGACGCTGAAGCGGCCCATGGAGTTCGAGGCGGCGCTGCTGAGC
CCCGGCTCCCCGAAGCGGCGGCGCTGCGCCCCTCTGCCCGGCCCCACTCCGGGCCTCAGGCCCCCGGACGCCGAGCCGCCGCCGCCGTTTCAGACGCAGACCCCACCGCAGAGTCTGCAGCAGCCCGCCCCGCCCGGCAGCGAGCGGCGC
CTTCCAACTCCGGAGCAAATTTTTCAGAACATAAAACAAGAATATAGTCGTTATCAGAGGTGGAGACATTTAGAAGTTGTTCTTAATCAGAGTGAAGCTTGTGCTTCGGAAAGTCAACCTCACTCCTCAGCACTCACAGCACCTAGCTCT
CCAGGGGAGCCAGGAAGTGGGACGGAAAGTGACACTTCTCCAGACTTCCACAATCAGGAAAATGAGCCCAGCCAGGAGGACCCTGAGGATCTGGATGGATCTGTGCAGGGAGTGAAACCTCAGAAGGCTGCTTCTTCTACTTCCTCAGGG
AGTCACCACAGCAGCCATAAAAAGCGAAAGAATAAAAACCGGCACAGCCCGTCTGGCATGTTTGATTATGACTTTGAGATTGATCTGAAGTTAAACAAAAAACCACGAGCTGACTATTAGAAGACACATTAGTGCAGAAGCTTCCAGGCT
GTAGAGCCCTGCTTCCCTTCTCTGACCTCACAAAGATAAACATCCTTCACCTGAGTTCGTGGCCATCCACCTCTGCTCTCCCAGACCCAGTGCCTGTGACTTTGAGTAGTTTGTTCTAAATGTGGTGACAAACAAGTCATTTCTGTAAGA
CATTGGGTCTTACTTTATGTCATTTTTAGTAACAGAACTGCAGGAAGATGAAGACAATGTTGTAATCCCAGCAAGTTGCTAACTGTGCGTTTCTCCCTTCTTAGAATGAATGTCTCCCCCAAAACTGGCTGGCACCAGCTTCATCTGTGA
TACCCTTCAAGAAATGTTCTCTGGTTTTGTTTTATGCTGAAAGTAGAACACAAGTCACATTTCAGATGGAGGCTGTAAATATCTGGCATTTTCTTATATTGTTTTATGTTTTCTTGTTTTTCTCTTGTTGTTTTTATCTTATTTTCTTTG
GGGTTTTTTTGTAATGCCTTTGTACAGCTCATACTTTCCTGCTGACATATCTGATCATCTCTTTCATGCAGTTGCCAATATTCATAACTGAAAATAATCTGGTTTATCATAAGTAAAATGGGAAACTTGCCTCTGTTTTTTGCAAGGGGA
GGTAAAGAGTGTTTAGTAATTACCTATCTTAAATCTTTCTGAGTTGGTAGTAGATTCATGTTCAAGGAACAGGAAAAATGGAAAAACATAAGTTTAAATCAGTTCTTTTTAAATAACTTTTTATTCTTTTGTATAAATAAAATTTCACAG
GCTTCAAATTCTCATGCTTTACTTTTAAACCCGAGATTGTTTTTTCACTTATTTATTCATATCATGCCTTATGGAAATTTCTTTTTCTGTATTTTCTCTCTTTGCTGGTATTCACCTGATTAAATATTGCTCTAAAAATCACCATGGCAT
ATGGAAAGTCTCAAAATTATACCAAAAGTGATAACTTATGTCGTTCTTAAGTGGAGTGAAAGGATAGCATCAGTGAGAGCCAGTGTTGCCCACCAGGTCTCCCTTTCTTGGAGGGCTTGTTGGGGCTGAGGAATCTGCTAGTAATCGTTA
CCTGCCTCTAGTGCTGTGGTGAACTTGCGACAGGGTCTGGCTGCACATTGGAATCACCTGAGAAGCTTTAAAATACTCATGCCTGGATCCCATCCCTAGAGACTGGGGTACAGCCTAGTTATTGGGAATTTCTTTAAAAGAGTTCCTGGG
ATTCTGATAAGAAGCCAGGTTGAGAACCACTACATTAGAAGACTGAATGGTTTAATTTACATCCTATGTTATGATTGGTCTAAGGGATAAGATTTGGGGTCTAACCTTTCCTTTCACTCTAGTTAGTCATAGTCCTTGACTTATGCCTAT
ATCTTTGTAAGAAATAGTATGTTTCATTTGTGATAGTATTGGTAGGGCTGAATATGGATGGCATCTACTGTAAAACAAGTCTACCTTGTCAGATGTGCAAAAGCTTTCACTCTTGTTCTCAAATAAACTTTTGTGGGTTTTTTT

N-Truncated Transcript (5UTR-3CDS) Sequences

C-Truncated Transcript (5CDS-3UTR) Sequences

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Fusion Protein Sequence for AKIRIN1_MEAF6

In-frame Fusion Protein Sequences.

>AKIRIN1_MEAF6_ENST00000432648_ENST00000296214_39463983_37967597 length=208nt
MACGATLKRPMEFEAALLSPGSPKRRRCAPLPGPTPGLRPPDAEPPPPFQTQTPPQSLQQPAPPGSERRLPTPEQIFQNIKQEYSRYQRWRHLEVVLNQSEACASESQPHSSALTAPSSPGEPGSGTESDTSPDFHNQENEPSQEDPEDL
DGSVQGVKPQKAASSTSSGSHHSSHKKRKNKNRHSPSGMFDYDFEIDLKLNKKPRADY

>AKIRIN1_MEAF6_ENST00000432648_ENST00000373074_39463983_37967597 length=198nt
MACGATLKRPMEFEAALLSPGSPKRRRCAPLPGPTPGLRPPDAEPPPPFQTQTPPQSLQQPAPPGSERRLPTPEQIFQNIKQEYSRYQRWRHLEVVLNQSEACASESQPHSSALTAPSSPGEPGSGTESDTSPDFHNQENEPSQEDPEDL
DGSVQGVKPQKAASSTSSGSHHSSHKKRKNKNRHRIDLKLNKKPRADY

>AKIRIN1_MEAF6_ENST00000432648_ENST00000373075_39463983_37967597 length=3014nt
MFSPAFLAEAMEDEERQKKLEAGKAKLAQFRQRKAQSDGQSPSKKQKKKRKTSSSKHDVSAHHDLNIDQSQCNEMYINSSQRVESTVIPESTIMRTLHSGEITSHEQGFSVELESEISTTADDCSSEVNGCSFVMRTGKPTNLLREEEFG
VDDSYSEQGAQDSPTHLEMMESELAGKQHEIEELNRELEEMRVTYGTEGLQQLQEFEAAIKQRDGIITQLTANLQQARREKDETMREFLELTEQSQKLQIQFQQLQASETLRNSTHSSTAADLLQAKQQILTHQQQLEEQDHLLEDYQKK
KEDFTMQISFLQEKIKVYEMEQDKKVENSNKEEIQEKETIIEELNTKIIEEEKKTLELKDKLTTADKLLGELQEQIVQKNQEIKNMKLELTNSKQKERQSSEEIKQLMGTVEELQKRNHKDSQFETDIVQRMEQETQRKLEQLRAELDEM
YGQQIVQMKQELIRQHMAQMEEMKTRHKGEMENALRSYSNITVNEDQIKLMNVAINELNIKLQDTNSQKEKLKEELGLILEEKCALQRQLEDLVEELSFSREQIQRARQTIAEQESKLNEAHKSLSTVEDLKAEIVSASESRKELELKHE
AEVTNYKIKLEMLEKEKNAVLDRMAESQEAELERLRTQLLFSHEEELSKLKEDLEIEHRINIEKLKDNLGIHYKQQIDGLQNEMSQKIETMQFEKDNLITKQNQLILEISKLKDLQQSLVNSKSEEMTLQINELQKEIEILRQEEKEKGT
LEQEVQELQLKTELLEKQMKEKENDLQEKFAQLEAENSILKDEKKTLEDMLKIHTPVSQEERLIFLDSIKSKSKDSVWEKEIEILIEENEDLKQQCIQLNEEIEKQRNTFSFAEKNFEVNYQELQEEYACLLKVKDDLEDSKNKQELEYK
SKLKALNEELHLQRINPTTVKMKSSVFDEDKTFVAETLEMGEVVEKDTTELMEKLEVTKREKLELSQRLSDLSEQLKQKHGEISFLNEEVKSLKQEKEQVSLRCRELEIIINHNRAENVQSCDTQVSSLLDGVVTMTSRGAEGSVSKVNK
SFGEESKIMVEDKVSFENMTVGEESKQEQLILDHLPSVTKESSLRATQPSENDKLQKELNVLKSEQNDLRLQMEAQRICLSLVYSTHVDQVREYMENEKDKALCSLKEELIFAQEEKIKELQKIHQLELQTMKTQETGDEGKPLHLLIGK
LQKAVSEECSYFLQTLCSVLGEYYTPALKCEVNAEDKENSGDYISENEDPELQDYRYEVQDFQENMHTLLNKVTEEYNKLLVLQTRLSKIWGQQTDGMKLEFGEENLPKEETEFLSIHSQMTNLEDIDVNHKSKLSSLQDLEKTKLEEQV
QELESLISSLQQQLKETEQNYEAEIHCLQKRLQAVSESTVPPSLPVDSVVITESDAQRTMYPGSCVKKNIDGTIEFSGEFGVKEETNIVKLLEKQYQEQLEEEVAKVIVSMSIAFAQQTELSRISGGKENTASSKQAHAVCQQEQHYFNE
MKLSQDQIGFQTFETVDVKFKEEFKPLSKELGEHGKEILLSNSDPHDIPESKDCVLTISEEMFSKDKTFIVRQSIHDEISVSSMDASRQLMLNEEQLEDMRQELVRQYQEHQQATELLRQAHMRQMERQREDQEQLQEEIKRLNRQLAQR
SSIDNENLVSERERVLLEELEALKQLSLAGREKLCCELRNSSTQTQNGNENQGEVEEQTFKEKELDRKPEDVPPEILSNERYALQKANNRLLKILLEVVKTTAAVEETIGRHVLGILDRSSKSQSSASLIWRSEAEASVKSCVHEEHTRV
TDESIPSYSGSDMPRNDINMWSKVTEEGTELSQRLVRSGFAGTEIDPENEELMLNISSRLQAAVEKLLEAISETSSQLEHAKVTQTELMRESFRQKQEATESLKCQEELRERLHEESRAREQLAVELSKAEGVIDGYADEKTLFERQIQE
KTDIIDRLEQELLCASNRLQELEAEQQQIQEERELLSRQKEAMKAEAGPVEQQLLQETEKLMKEKLEVQCQAEKVRDDLQKQVKALEIDVEEQVSRFIELEQEKNTELMDLRQQNQALEKQLEKMRKFLDEQAIDREHERDVFQQEIQKL
EQQLKVVPRFQPISEHQTREVEQLANHLKEKTDKCSELLLSKEQLQRDIQERNEEIEKLEFRVRELEQALLVSADTFQKVEDRKHFGAVEAKPELSLEVQLQAERDAIDRKEKEITNLEEQLEQFREELENKNEEVQQLHMQLEIQKKES
TTRLQELEQENKLFKDDMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQVTKLQQQLKITTDNKVIEEKNELIRDLETQIECLMSDQECVKRNREEEIEQLNEVIEKLQQELANIGQKTSMNAHSLSEEADSLKHQLDV
VIAEKLALEQQVETANEEMTFMKNVLKETNFKMNQLTQELFSLKRERESVEKIQSIPENSVNVAIDHLSKDKPELEVVLTEDALKSLENQTYFKSFEENGKGSIINLETRLLQLESTVSAKDLELTQCYKQIKDMQEQGQFETEMLQKKI
VNLQKIVEEKVAAALVSQIQLEAVQEYAKFCQDNQTISSEPERTNIQNLNQLREDELGSDISALTLRISELESQVVEMHTSLILEKEQVEIAEKNVLEKEKKLLELQKLLEGNEKKQREKEKKRSPQDVEVLKTTTELFHSNEESGFFNE
LEALRAESVATKAELASYKEKAEKLQEELLVKETNMTSLQKDLSQVRDHLAEAKEKLSILEKEDETEVQESKKACMFEPLPIKLSKSIASQTDGTLKISSSNQTPQILVKNAGIQINLQSECSSEEVTEIISQFTEKIEKMQELHAAEIL
DMESRHISETETLKREHYVAVQLLKEECGTLKAVIQCLRSKEGSSIPELAHSDAYQTREICSSERFTLYSSKNLRQAWNKLSYVNHAEDLASKLLQCSPKNRLSAQAALSHEYFSDLPPRLWELTDMSSIFTVPNVRLQPEAGESMRAFG
KNNSYGKSLSNSKH

>AKIRIN1_MEAF6_ENST00000446189_ENST00000296214_39463983_37967597 length=208nt
MACGATLKRPMEFEAALLSPGSPKRRRCAPLPGPTPGLRPPDAEPPPPFQTQTPPQSLQQPAPPGSERRLPTPEQIFQNIKQEYSRYQRWRHLEVVLNQSEACASESQPHSSALTAPSSPGEPGSGTESDTSPDFHNQENEPSQEDPEDL
DGSVQGVKPQKAASSTSSGSHHSSHKKRKNKNRHSPSGMFDYDFEIDLKLNKKPRADY

>AKIRIN1_MEAF6_ENST00000446189_ENST00000373074_39463983_37967597 length=198nt
MACGATLKRPMEFEAALLSPGSPKRRRCAPLPGPTPGLRPPDAEPPPPFQTQTPPQSLQQPAPPGSERRLPTPEQIFQNIKQEYSRYQRWRHLEVVLNQSEACASESQPHSSALTAPSSPGEPGSGTESDTSPDFHNQENEPSQEDPEDL
DGSVQGVKPQKAASSTSSGSHHSSHKKRKNKNRHRIDLKLNKKPRADY

>AKIRIN1_MEAF6_ENST00000446189_ENST00000373075_39463983_37967597 length=198nt
MACGATLKRPMEFEAALLSPGSPKRRRCAPLPGPTPGLRPPDAEPPPPFQTQTPPQSLQQPAPPGSERRLPTPEQIFQNIKQEYSRYQRWRHLEVVLNQSEACASESQPHSSALTAPSSPGEPGSGTESDTSPDFHNQENEPSQEDPEDL
DGSVQGVKPQKAASSTSSGSHHSSHKKRKNKNRHRIDLKLNKKPRADY

N-Truncated Protein (5UTR-3CDS) Sequences

C-Truncated Protein (5CDS-3UTR) Sequences

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Personalized Fusion Protein Sequence for AKIRIN1_MEAF6

TCGA Kinase/DNA-binding Domain Mutated Fusion Protein Sequences

Num

Gene Group

Domain Loci

Fusion Protein ID

Fusion Gene Name

Partner

Mutated Residue in WT Protein

Seq. Length

Mutated Residue in Fusion Protein

CCLE Kinase/DNA-binding Domain Mutated Fusion Protein Sequences

Num

Gene Group

Domain Loci

Fusion Protein ID

Fusion Gene Name

Partner

Mutated Residue in WT Protein

Seq. Length

Mutated Residue in Fusion Protein

TCGA All Mutated Fusion Protein Sequences

>AKIRIN1_MEAF6_ENST00000432648_ENST00000296214_39463983_37967597_5-gene_p.R86S_208_R86S length=208AA
MACGATLKRPMEFEAALLSPGSPKRRRCAPLPGPTPGLRPPDAEPPPPFQTQTPPQSLQQPAPPGSERRLPTPEQIFQNIKQEYSSYQRWRHLEVVLNQSEACASESQPHSSALTAPSSPGEPGSGTESDTSPDFHNQENEPSQEDPEDL
DGSVQGVKPQKAASSTSSGSHHSSHKKRKNKNRHSPSGMFDYDFEIDLKLNKKPRADY

>AKIRIN1_MEAF6_ENST00000432648_ENST00000296214_39463983_37967597_5-gene_p.Q99E_208_Q99E length=208AA
MACGATLKRPMEFEAALLSPGSPKRRRCAPLPGPTPGLRPPDAEPPPPFQTQTPPQSLQQPAPPGSERRLPTPEQIFQNIKQEYSRYQRWRHLEVVLNESEACASESQPHSSALTAPSSPGEPGSGTESDTSPDFHNQENEPSQEDPEDL
DGSVQGVKPQKAASSTSSGSHHSSHKKRKNKNRHSPSGMFDYDFEIDLKLNKKPRADY

>AKIRIN1_MEAF6_ENST00000432648_ENST00000296214_39463983_37967597_5-gene_p.Q75H_208_Q75H length=208AA
MACGATLKRPMEFEAALLSPGSPKRRRCAPLPGPTPGLRPPDAEPPPPFQTQTPPQSLQQPAPPGSERRLPTPEHIFQNIKQEYSRYQRWRHLEVVLNQSEACASESQPHSSALTAPSSPGEPGSGTESDTSPDFHNQENEPSQEDPEDL
DGSVQGVKPQKAASSTSSGSHHSSHKKRKNKNRHSPSGMFDYDFEIDLKLNKKPRADY

>AKIRIN1_MEAF6_ENST00000432648_ENST00000296214_39463983_37967597_5-gene_p.S105L_208_S105L length=208AA
MACGATLKRPMEFEAALLSPGSPKRRRCAPLPGPTPGLRPPDAEPPPPFQTQTPPQSLQQPAPPGSERRLPTPEQIFQNIKQEYSRYQRWRHLEVVLNQSEACALESQPHSSALTAPSSPGEPGSGTESDTSPDFHNQENEPSQEDPEDL
DGSVQGVKPQKAASSTSSGSHHSSHKKRKNKNRHSPSGMFDYDFEIDLKLNKKPRADY

>AKIRIN1_MEAF6_ENST00000432648_ENST00000296214_39463983_37967597_5-gene_p.Q108K_208_Q108K length=208AA
MACGATLKRPMEFEAALLSPGSPKRRRCAPLPGPTPGLRPPDAEPPPPFQTQTPPQSLQQPAPPGSERRLPTPEQIFQNIKQEYSRYQRWRHLEVVLNQSEACASESKPHSSALTAPSSPGEPGSGTESDTSPDFHNQENEPSQEDPEDL
DGSVQGVKPQKAASSTSSGSHHSSHKKRKNKNRHSPSGMFDYDFEIDLKLNKKPRADY

>AKIRIN1_MEAF6_ENST00000432648_ENST00000373074_39463983_37967597_5-gene_p.R86S_198_R86S length=198AA
MACGATLKRPMEFEAALLSPGSPKRRRCAPLPGPTPGLRPPDAEPPPPFQTQTPPQSLQQPAPPGSERRLPTPEQIFQNIKQEYSSYQRWRHLEVVLNQSEACASESQPHSSALTAPSSPGEPGSGTESDTSPDFHNQENEPSQEDPEDL
DGSVQGVKPQKAASSTSSGSHHSSHKKRKNKNRHRIDLKLNKKPRADY

>AKIRIN1_MEAF6_ENST00000432648_ENST00000373074_39463983_37967597_3-gene_p.D139N_198_D146N length=198AA
MACGATLKRPMEFEAALLSPGSPKRRRCAPLPGPTPGLRPPDAEPPPPFQTQTPPQSLQQPAPPGSERRLPTPEQIFQNIKQEYSRYQRWRHLEVVLNQSEACASESQPHSSALTAPSSPGEPGSGTESDTSPDFHNQENEPSQENPEDL
DGSVQGVKPQKAASSTSSGSHHSSHKKRKNKNRHRIDLKLNKKPRADY

>AKIRIN1_MEAF6_ENST00000432648_ENST00000373074_39463983_37967597_3-gene_p.K172N_198_K179N length=198AA
MACGATLKRPMEFEAALLSPGSPKRRRCAPLPGPTPGLRPPDAEPPPPFQTQTPPQSLQQPAPPGSERRLPTPEQIFQNIKQEYSRYQRWRHLEVVLNQSEACASESQPHSSALTAPSSPGEPGSGTESDTSPDFHNQENEPSQEDPEDL
DGSVQGVKPQKAASSTSSGSHHSSHKKRNNKNRHRIDLKLNKKPRADY

>AKIRIN1_MEAF6_ENST00000432648_ENST00000373074_39463983_37967597_3-gene_p.E132D_198_E139D length=198AA
MACGATLKRPMEFEAALLSPGSPKRRRCAPLPGPTPGLRPPDAEPPPPFQTQTPPQSLQQPAPPGSERRLPTPEQIFQNIKQEYSRYQRWRHLEVVLNQSEACASESQPHSSALTAPSSPGEPGSGTESDTSPDFHNQDNEPSQEDPEDL
DGSVQGVKPQKAASSTSSGSHHSSHKKRKNKNRHRIDLKLNKKPRADY

>AKIRIN1_MEAF6_ENST00000432648_ENST00000373074_39463983_37967597_5-gene_p.Q99E_198_Q99E length=198AA
MACGATLKRPMEFEAALLSPGSPKRRRCAPLPGPTPGLRPPDAEPPPPFQTQTPPQSLQQPAPPGSERRLPTPEQIFQNIKQEYSRYQRWRHLEVVLNESEACASESQPHSSALTAPSSPGEPGSGTESDTSPDFHNQENEPSQEDPEDL
DGSVQGVKPQKAASSTSSGSHHSSHKKRKNKNRHRIDLKLNKKPRADY

>AKIRIN1_MEAF6_ENST00000432648_ENST00000373074_39463983_37967597_both_p.Q75H-p.S160F_198_Q75H;S167F length=198AA
MACGATLKRPMEFEAALLSPGSPKRRRCAPLPGPTPGLRPPDAEPPPPFQTQTPPQSLQQPAPPGSERRLPTPEHIFQNIKQEYSRYQRWRHLEVVLNQSEACASESQPHSSALTAPSSPGEPGSGTESDTSPDFHNQENEPSQEDPEDL
DGSVQGVKPQKAASSTFSGSHHSSHKKRKNKNRHRIDLKLNKKPRADY

>AKIRIN1_MEAF6_ENST00000432648_ENST00000373074_39463983_37967597_5-gene_p.S105L_198_S105L length=198AA
MACGATLKRPMEFEAALLSPGSPKRRRCAPLPGPTPGLRPPDAEPPPPFQTQTPPQSLQQPAPPGSERRLPTPEQIFQNIKQEYSRYQRWRHLEVVLNQSEACALESQPHSSALTAPSSPGEPGSGTESDTSPDFHNQENEPSQEDPEDL
DGSVQGVKPQKAASSTSSGSHHSSHKKRKNKNRHRIDLKLNKKPRADY

>AKIRIN1_MEAF6_ENST00000432648_ENST00000373074_39463983_37967597_5-gene_p.Q108K_198_Q108K length=198AA
MACGATLKRPMEFEAALLSPGSPKRRRCAPLPGPTPGLRPPDAEPPPPFQTQTPPQSLQQPAPPGSERRLPTPEQIFQNIKQEYSRYQRWRHLEVVLNQSEACASESKPHSSALTAPSSPGEPGSGTESDTSPDFHNQENEPSQEDPEDL
DGSVQGVKPQKAASSTSSGSHHSSHKKRKNKNRHRIDLKLNKKPRADY

>AKIRIN1_MEAF6_ENST00000432648_ENST00000373074_39463983_37967597_3-gene_p.R176Q_198_R183Q length=198AA
MACGATLKRPMEFEAALLSPGSPKRRRCAPLPGPTPGLRPPDAEPPPPFQTQTPPQSLQQPAPPGSERRLPTPEQIFQNIKQEYSRYQRWRHLEVVLNQSEACASESQPHSSALTAPSSPGEPGSGTESDTSPDFHNQENEPSQEDPEDL
DGSVQGVKPQKAASSTSSGSHHSSHKKRKNKNQHRIDLKLNKKPRADY

>AKIRIN1_MEAF6_ENST00000432648_ENST00000373074_39463983_37967597_3-gene_p.P116S_198_P123S length=198AA
MACGATLKRPMEFEAALLSPGSPKRRRCAPLPGPTPGLRPPDAEPPPPFQTQTPPQSLQQPAPPGSERRLPTPEQIFQNIKQEYSRYQRWRHLEVVLNQSEACASESQPHSSALTAPSSPGESGSGTESDTSPDFHNQENEPSQEDPEDL
DGSVQGVKPQKAASSTSSGSHHSSHKKRKNKNRHRIDLKLNKKPRADY

>AKIRIN1_MEAF6_ENST00000446189_ENST00000296214_39463983_37967597_5-gene_p.R86S_208_R86S length=208AA
MACGATLKRPMEFEAALLSPGSPKRRRCAPLPGPTPGLRPPDAEPPPPFQTQTPPQSLQQPAPPGSERRLPTPEQIFQNIKQEYSSYQRWRHLEVVLNQSEACASESQPHSSALTAPSSPGEPGSGTESDTSPDFHNQENEPSQEDPEDL
DGSVQGVKPQKAASSTSSGSHHSSHKKRKNKNRHSPSGMFDYDFEIDLKLNKKPRADY

>AKIRIN1_MEAF6_ENST00000446189_ENST00000296214_39463983_37967597_5-gene_p.Q99E_208_Q99E length=208AA
MACGATLKRPMEFEAALLSPGSPKRRRCAPLPGPTPGLRPPDAEPPPPFQTQTPPQSLQQPAPPGSERRLPTPEQIFQNIKQEYSRYQRWRHLEVVLNESEACASESQPHSSALTAPSSPGEPGSGTESDTSPDFHNQENEPSQEDPEDL
DGSVQGVKPQKAASSTSSGSHHSSHKKRKNKNRHSPSGMFDYDFEIDLKLNKKPRADY

>AKIRIN1_MEAF6_ENST00000446189_ENST00000296214_39463983_37967597_5-gene_p.Q75H_208_Q75H length=208AA
MACGATLKRPMEFEAALLSPGSPKRRRCAPLPGPTPGLRPPDAEPPPPFQTQTPPQSLQQPAPPGSERRLPTPEHIFQNIKQEYSRYQRWRHLEVVLNQSEACASESQPHSSALTAPSSPGEPGSGTESDTSPDFHNQENEPSQEDPEDL
DGSVQGVKPQKAASSTSSGSHHSSHKKRKNKNRHSPSGMFDYDFEIDLKLNKKPRADY

>AKIRIN1_MEAF6_ENST00000446189_ENST00000296214_39463983_37967597_5-gene_p.S105L_208_S105L length=208AA
MACGATLKRPMEFEAALLSPGSPKRRRCAPLPGPTPGLRPPDAEPPPPFQTQTPPQSLQQPAPPGSERRLPTPEQIFQNIKQEYSRYQRWRHLEVVLNQSEACALESQPHSSALTAPSSPGEPGSGTESDTSPDFHNQENEPSQEDPEDL
DGSVQGVKPQKAASSTSSGSHHSSHKKRKNKNRHSPSGMFDYDFEIDLKLNKKPRADY

>AKIRIN1_MEAF6_ENST00000446189_ENST00000296214_39463983_37967597_5-gene_p.Q108K_208_Q108K length=208AA
MACGATLKRPMEFEAALLSPGSPKRRRCAPLPGPTPGLRPPDAEPPPPFQTQTPPQSLQQPAPPGSERRLPTPEQIFQNIKQEYSRYQRWRHLEVVLNQSEACASESKPHSSALTAPSSPGEPGSGTESDTSPDFHNQENEPSQEDPEDL
DGSVQGVKPQKAASSTSSGSHHSSHKKRKNKNRHSPSGMFDYDFEIDLKLNKKPRADY

>AKIRIN1_MEAF6_ENST00000446189_ENST00000373074_39463983_37967597_5-gene_p.R86S_198_R86S length=198AA
MACGATLKRPMEFEAALLSPGSPKRRRCAPLPGPTPGLRPPDAEPPPPFQTQTPPQSLQQPAPPGSERRLPTPEQIFQNIKQEYSSYQRWRHLEVVLNQSEACASESQPHSSALTAPSSPGEPGSGTESDTSPDFHNQENEPSQEDPEDL
DGSVQGVKPQKAASSTSSGSHHSSHKKRKNKNRHRIDLKLNKKPRADY

>AKIRIN1_MEAF6_ENST00000446189_ENST00000373074_39463983_37967597_3-gene_p.D139N_198_D146N length=198AA
MACGATLKRPMEFEAALLSPGSPKRRRCAPLPGPTPGLRPPDAEPPPPFQTQTPPQSLQQPAPPGSERRLPTPEQIFQNIKQEYSRYQRWRHLEVVLNQSEACASESQPHSSALTAPSSPGEPGSGTESDTSPDFHNQENEPSQENPEDL
DGSVQGVKPQKAASSTSSGSHHSSHKKRKNKNRHRIDLKLNKKPRADY

>AKIRIN1_MEAF6_ENST00000446189_ENST00000373074_39463983_37967597_3-gene_p.K172N_198_K179N length=198AA
MACGATLKRPMEFEAALLSPGSPKRRRCAPLPGPTPGLRPPDAEPPPPFQTQTPPQSLQQPAPPGSERRLPTPEQIFQNIKQEYSRYQRWRHLEVVLNQSEACASESQPHSSALTAPSSPGEPGSGTESDTSPDFHNQENEPSQEDPEDL
DGSVQGVKPQKAASSTSSGSHHSSHKKRNNKNRHRIDLKLNKKPRADY

>AKIRIN1_MEAF6_ENST00000446189_ENST00000373074_39463983_37967597_3-gene_p.E132D_198_E139D length=198AA
MACGATLKRPMEFEAALLSPGSPKRRRCAPLPGPTPGLRPPDAEPPPPFQTQTPPQSLQQPAPPGSERRLPTPEQIFQNIKQEYSRYQRWRHLEVVLNQSEACASESQPHSSALTAPSSPGEPGSGTESDTSPDFHNQDNEPSQEDPEDL
DGSVQGVKPQKAASSTSSGSHHSSHKKRKNKNRHRIDLKLNKKPRADY

>AKIRIN1_MEAF6_ENST00000446189_ENST00000373074_39463983_37967597_5-gene_p.Q99E_198_Q99E length=198AA
MACGATLKRPMEFEAALLSPGSPKRRRCAPLPGPTPGLRPPDAEPPPPFQTQTPPQSLQQPAPPGSERRLPTPEQIFQNIKQEYSRYQRWRHLEVVLNESEACASESQPHSSALTAPSSPGEPGSGTESDTSPDFHNQENEPSQEDPEDL
DGSVQGVKPQKAASSTSSGSHHSSHKKRKNKNRHRIDLKLNKKPRADY

>AKIRIN1_MEAF6_ENST00000446189_ENST00000373074_39463983_37967597_both_p.Q75H-p.S160F_198_Q75H;S167F length=198AA
MACGATLKRPMEFEAALLSPGSPKRRRCAPLPGPTPGLRPPDAEPPPPFQTQTPPQSLQQPAPPGSERRLPTPEHIFQNIKQEYSRYQRWRHLEVVLNQSEACASESQPHSSALTAPSSPGEPGSGTESDTSPDFHNQENEPSQEDPEDL
DGSVQGVKPQKAASSTFSGSHHSSHKKRKNKNRHRIDLKLNKKPRADY

>AKIRIN1_MEAF6_ENST00000446189_ENST00000373074_39463983_37967597_5-gene_p.S105L_198_S105L length=198AA
MACGATLKRPMEFEAALLSPGSPKRRRCAPLPGPTPGLRPPDAEPPPPFQTQTPPQSLQQPAPPGSERRLPTPEQIFQNIKQEYSRYQRWRHLEVVLNQSEACALESQPHSSALTAPSSPGEPGSGTESDTSPDFHNQENEPSQEDPEDL
DGSVQGVKPQKAASSTSSGSHHSSHKKRKNKNRHRIDLKLNKKPRADY

>AKIRIN1_MEAF6_ENST00000446189_ENST00000373074_39463983_37967597_5-gene_p.Q108K_198_Q108K length=198AA
MACGATLKRPMEFEAALLSPGSPKRRRCAPLPGPTPGLRPPDAEPPPPFQTQTPPQSLQQPAPPGSERRLPTPEQIFQNIKQEYSRYQRWRHLEVVLNQSEACASESKPHSSALTAPSSPGEPGSGTESDTSPDFHNQENEPSQEDPEDL
DGSVQGVKPQKAASSTSSGSHHSSHKKRKNKNRHRIDLKLNKKPRADY

>AKIRIN1_MEAF6_ENST00000446189_ENST00000373074_39463983_37967597_3-gene_p.R176Q_198_R183Q length=198AA
MACGATLKRPMEFEAALLSPGSPKRRRCAPLPGPTPGLRPPDAEPPPPFQTQTPPQSLQQPAPPGSERRLPTPEQIFQNIKQEYSRYQRWRHLEVVLNQSEACASESQPHSSALTAPSSPGEPGSGTESDTSPDFHNQENEPSQEDPEDL
DGSVQGVKPQKAASSTSSGSHHSSHKKRKNKNQHRIDLKLNKKPRADY

>AKIRIN1_MEAF6_ENST00000446189_ENST00000373074_39463983_37967597_3-gene_p.P116S_198_P123S length=198AA
MACGATLKRPMEFEAALLSPGSPKRRRCAPLPGPTPGLRPPDAEPPPPFQTQTPPQSLQQPAPPGSERRLPTPEQIFQNIKQEYSRYQRWRHLEVVLNQSEACASESQPHSSALTAPSSPGESGSGTESDTSPDFHNQENEPSQEDPEDL
DGSVQGVKPQKAASSTSSGSHHSSHKKRKNKNRHRIDLKLNKKPRADY

>AKIRIN1_MEAF6_ENST00000446189_ENST00000373075_39463983_37967597_5-gene_p.R86S_198_R86S length=198AA
MACGATLKRPMEFEAALLSPGSPKRRRCAPLPGPTPGLRPPDAEPPPPFQTQTPPQSLQQPAPPGSERRLPTPEQIFQNIKQEYSSYQRWRHLEVVLNQSEACASESQPHSSALTAPSSPGEPGSGTESDTSPDFHNQENEPSQEDPEDL
DGSVQGVKPQKAASSTSSGSHHSSHKKRKNKNRHRIDLKLNKKPRADY

>AKIRIN1_MEAF6_ENST00000446189_ENST00000373075_39463983_37967597_3-gene_p.D139N_198_D146N length=198AA
MACGATLKRPMEFEAALLSPGSPKRRRCAPLPGPTPGLRPPDAEPPPPFQTQTPPQSLQQPAPPGSERRLPTPEQIFQNIKQEYSRYQRWRHLEVVLNQSEACASESQPHSSALTAPSSPGEPGSGTESDTSPDFHNQENEPSQENPEDL
DGSVQGVKPQKAASSTSSGSHHSSHKKRKNKNRHRIDLKLNKKPRADY

>AKIRIN1_MEAF6_ENST00000446189_ENST00000373075_39463983_37967597_3-gene_p.K172N_198_K179N length=198AA
MACGATLKRPMEFEAALLSPGSPKRRRCAPLPGPTPGLRPPDAEPPPPFQTQTPPQSLQQPAPPGSERRLPTPEQIFQNIKQEYSRYQRWRHLEVVLNQSEACASESQPHSSALTAPSSPGEPGSGTESDTSPDFHNQENEPSQEDPEDL
DGSVQGVKPQKAASSTSSGSHHSSHKKRNNKNRHRIDLKLNKKPRADY

>AKIRIN1_MEAF6_ENST00000446189_ENST00000373075_39463983_37967597_3-gene_p.E132D_198_E139D length=198AA
MACGATLKRPMEFEAALLSPGSPKRRRCAPLPGPTPGLRPPDAEPPPPFQTQTPPQSLQQPAPPGSERRLPTPEQIFQNIKQEYSRYQRWRHLEVVLNQSEACASESQPHSSALTAPSSPGEPGSGTESDTSPDFHNQDNEPSQEDPEDL
DGSVQGVKPQKAASSTSSGSHHSSHKKRKNKNRHRIDLKLNKKPRADY

>AKIRIN1_MEAF6_ENST00000446189_ENST00000373075_39463983_37967597_5-gene_p.Q99E_198_Q99E length=198AA
MACGATLKRPMEFEAALLSPGSPKRRRCAPLPGPTPGLRPPDAEPPPPFQTQTPPQSLQQPAPPGSERRLPTPEQIFQNIKQEYSRYQRWRHLEVVLNESEACASESQPHSSALTAPSSPGEPGSGTESDTSPDFHNQENEPSQEDPEDL
DGSVQGVKPQKAASSTSSGSHHSSHKKRKNKNRHRIDLKLNKKPRADY

>AKIRIN1_MEAF6_ENST00000446189_ENST00000373075_39463983_37967597_both_p.Q75H-p.S160F_198_Q75H;S167F length=198AA
MACGATLKRPMEFEAALLSPGSPKRRRCAPLPGPTPGLRPPDAEPPPPFQTQTPPQSLQQPAPPGSERRLPTPEHIFQNIKQEYSRYQRWRHLEVVLNQSEACASESQPHSSALTAPSSPGEPGSGTESDTSPDFHNQENEPSQEDPEDL
DGSVQGVKPQKAASSTFSGSHHSSHKKRKNKNRHRIDLKLNKKPRADY

>AKIRIN1_MEAF6_ENST00000446189_ENST00000373075_39463983_37967597_5-gene_p.S105L_198_S105L length=198AA
MACGATLKRPMEFEAALLSPGSPKRRRCAPLPGPTPGLRPPDAEPPPPFQTQTPPQSLQQPAPPGSERRLPTPEQIFQNIKQEYSRYQRWRHLEVVLNQSEACALESQPHSSALTAPSSPGEPGSGTESDTSPDFHNQENEPSQEDPEDL
DGSVQGVKPQKAASSTSSGSHHSSHKKRKNKNRHRIDLKLNKKPRADY

>AKIRIN1_MEAF6_ENST00000446189_ENST00000373075_39463983_37967597_5-gene_p.Q108K_198_Q108K length=198AA
MACGATLKRPMEFEAALLSPGSPKRRRCAPLPGPTPGLRPPDAEPPPPFQTQTPPQSLQQPAPPGSERRLPTPEQIFQNIKQEYSRYQRWRHLEVVLNQSEACASESKPHSSALTAPSSPGEPGSGTESDTSPDFHNQENEPSQEDPEDL
DGSVQGVKPQKAASSTSSGSHHSSHKKRKNKNRHRIDLKLNKKPRADY

>AKIRIN1_MEAF6_ENST00000446189_ENST00000373075_39463983_37967597_3-gene_p.R176Q_198_R183Q length=198AA
MACGATLKRPMEFEAALLSPGSPKRRRCAPLPGPTPGLRPPDAEPPPPFQTQTPPQSLQQPAPPGSERRLPTPEQIFQNIKQEYSRYQRWRHLEVVLNQSEACASESQPHSSALTAPSSPGEPGSGTESDTSPDFHNQENEPSQEDPEDL
DGSVQGVKPQKAASSTSSGSHHSSHKKRKNKNQHRIDLKLNKKPRADY

>AKIRIN1_MEAF6_ENST00000446189_ENST00000373075_39463983_37967597_3-gene_p.P116S_198_P123S length=198AA
MACGATLKRPMEFEAALLSPGSPKRRRCAPLPGPTPGLRPPDAEPPPPFQTQTPPQSLQQPAPPGSERRLPTPEQIFQNIKQEYSRYQRWRHLEVVLNQSEACASESQPHSSALTAPSSPGESGSGTESDTSPDFHNQENEPSQEDPEDL
DGSVQGVKPQKAASSTSSGSHHSSHKKRKNKNRHRIDLKLNKKPRADY

Fusion Protein ID	Sample ID	Mutated Partner	AAchange in WT	Seq. Length	AAchange in Fusion
ENST00000432648_ENST00000296214_39463983_37967597	TCGA-86-7701-01A	5-gene	p.R86S	208	R86S
ENST00000432648_ENST00000296214_39463983_37967597	TCGA-E9-A3QA-01A	5-gene	p.Q99E	208	Q99E
ENST00000432648_ENST00000296214_39463983_37967597	TCGA-FI-A2D0-01A	5-gene	p.Q75H	208	Q75H
ENST00000432648_ENST00000296214_39463983_37967597	TCGA-FV-A23B-01A	5-gene	p.S105L	208	S105L
ENST00000432648_ENST00000296214_39463983_37967597	TCGA-KQ-A41N-01A	5-gene	p.Q108K	208	Q108K
ENST00000432648_ENST00000373074_39463983_37967597	TCGA-86-7701-01A	5-gene	p.R86S	198	R86S
ENST00000432648_ENST00000373074_39463983_37967597	TCGA-A5-A0G1-01A	3-gene	p.D139N	198	D146N
ENST00000432648_ENST00000373074_39463983_37967597	TCGA-AA-A010-01A	3-gene	p.K172N	198	K179N
ENST00000432648_ENST00000373074_39463983_37967597	TCGA-B5-A0JY-01A	3-gene	p.E132D	198	E139D
ENST00000432648_ENST00000373074_39463983_37967597	TCGA-E9-A3QA-01A	5-gene	p.Q99E	198	Q99E
ENST00000432648_ENST00000373074_39463983_37967597	TCGA-FI-A2D0-01A	both	p.Q75H-p.S160F	198	Q75H;S167F
ENST00000432648_ENST00000373074_39463983_37967597	TCGA-FV-A23B-01A	5-gene	p.S105L	198	S105L
ENST00000432648_ENST00000373074_39463983_37967597	TCGA-KQ-A41N-01A	5-gene	p.Q108K	198	Q108K
ENST00000432648_ENST00000373074_39463983_37967597	TCGA-L5-A4OI-01A	3-gene	p.R176Q	198	R183Q
ENST00000432648_ENST00000373074_39463983_37967597	TCGA-WE-A8ZT-06A	3-gene	p.P116S	198	P123S
ENST00000446189_ENST00000296214_39463983_37967597	TCGA-86-7701-01A	5-gene	p.R86S	208	R86S
ENST00000446189_ENST00000296214_39463983_37967597	TCGA-E9-A3QA-01A	5-gene	p.Q99E	208	Q99E
ENST00000446189_ENST00000296214_39463983_37967597	TCGA-FI-A2D0-01A	5-gene	p.Q75H	208	Q75H
ENST00000446189_ENST00000296214_39463983_37967597	TCGA-FV-A23B-01A	5-gene	p.S105L	208	S105L
ENST00000446189_ENST00000296214_39463983_37967597	TCGA-KQ-A41N-01A	5-gene	p.Q108K	208	Q108K
ENST00000446189_ENST00000373074_39463983_37967597	TCGA-86-7701-01A	5-gene	p.R86S	198	R86S
ENST00000446189_ENST00000373074_39463983_37967597	TCGA-A5-A0G1-01A	3-gene	p.D139N	198	D146N
ENST00000446189_ENST00000373074_39463983_37967597	TCGA-AA-A010-01A	3-gene	p.K172N	198	K179N
ENST00000446189_ENST00000373074_39463983_37967597	TCGA-B5-A0JY-01A	3-gene	p.E132D	198	E139D
ENST00000446189_ENST00000373074_39463983_37967597	TCGA-E9-A3QA-01A	5-gene	p.Q99E	198	Q99E
ENST00000446189_ENST00000373074_39463983_37967597	TCGA-FI-A2D0-01A	both	p.Q75H-p.S160F	198	Q75H;S167F
ENST00000446189_ENST00000373074_39463983_37967597	TCGA-FV-A23B-01A	5-gene	p.S105L	198	S105L
ENST00000446189_ENST00000373074_39463983_37967597	TCGA-KQ-A41N-01A	5-gene	p.Q108K	198	Q108K
ENST00000446189_ENST00000373074_39463983_37967597	TCGA-L5-A4OI-01A	3-gene	p.R176Q	198	R183Q
ENST00000446189_ENST00000373074_39463983_37967597	TCGA-WE-A8ZT-06A	3-gene	p.P116S	198	P123S
ENST00000446189_ENST00000373075_39463983_37967597	TCGA-86-7701-01A	5-gene	p.R86S	198	R86S
ENST00000446189_ENST00000373075_39463983_37967597	TCGA-A5-A0G1-01A	3-gene	p.D139N	198	D146N
ENST00000446189_ENST00000373075_39463983_37967597	TCGA-AA-A010-01A	3-gene	p.K172N	198	K179N
ENST00000446189_ENST00000373075_39463983_37967597	TCGA-B5-A0JY-01A	3-gene	p.E132D	198	E139D
ENST00000446189_ENST00000373075_39463983_37967597	TCGA-E9-A3QA-01A	5-gene	p.Q99E	198	Q99E
ENST00000446189_ENST00000373075_39463983_37967597	TCGA-FI-A2D0-01A	both	p.Q75H-p.S160F	198	Q75H;S167F
ENST00000446189_ENST00000373075_39463983_37967597	TCGA-FV-A23B-01A	5-gene	p.S105L	198	S105L
ENST00000446189_ENST00000373075_39463983_37967597	TCGA-KQ-A41N-01A	5-gene	p.Q108K	198	Q108K
ENST00000446189_ENST00000373075_39463983_37967597	TCGA-L5-A4OI-01A	3-gene	p.R176Q	198	R183Q
ENST00000446189_ENST00000373075_39463983_37967597	TCGA-WE-A8ZT-06A	3-gene	p.P116S	198	P123S

CCLE All Mutated Fusion Protein Sequences

Fusion Protein ID

Sample ID

Mutated Partner

AAchange in WT

Seq. Length

AAchange in Fusion

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Fusion Gene Exprssed Samples for AKIRIN1_MEAF6

RNA-seq based fusion gene expressed samples.

Source	Study	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB		LUAD	TCGA-55-6712-01A	AKIRIN1	chr1	39463983	-	MEAF6	chr1	37967597	-
ChimerDB		LUAD	TCGA-55-6712-01A	AKIRIN1	chr1	39463983	+	MEAF6	chr1	37967597	-
ChimerDB		LUAD	TCGA-55-6712-01A	AKIRIN1	chr1	39463983	+	MEAF6	chr1	37967597	-
ChimerDB		LUAD	TCGA-55-6712	AKIRIN1	chr1	39463983	+	MEAF6	chr1	37967597	-
TCGAfusionPortal		LUAD	TCGA-55-6712-01A	AKIRIN1	chr1	39463983	+	MEAF6	chr1	37967597	-
WashU		LUAD	TCGA-55-6712-01A	AKIRIN1	chr1	39463983	+	MEAF6	chr1	37967597	-
cBioPortal	LUAD_TCGA_PAN_CAN_ATLAS_2018	LUAD	TCGA-55-6712-01	AKIRIN1	chr1	38998311		MEAF6	chr1	37501996

DNA-seq based fusion gene expressed samples.

Source

Study

Disease

Sample

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

SV type

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Related Drugs for AKIRIN1_MEAF6

PubMed Abstract Search With ['A-B' AND 'drug'], ['A::B' AND 'drug']
* For more details on the Studied, Reported, Approved Drugs targeting this fusion gene, Go to FusionPub.

PMID

Fusion Gene Name

Drug

Study Title

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status