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	Fusion Gene Summary
	Fusion Gene Breakpoints
	Tumorigenic MoA (Mechanism of Action) Scenarios of Fusion Geness
	Fusion Genomic Features
	Fusion Gene ORF Annotations
	Fusion Protein Retained/Non-Retained Functional Features
	Fusion Transcript Sequences
	Fusion Protein Sequences
	Personalized Fusion Protein Sequences
	Fusion Gene Expressed Samples
	Related Drugs

Fusion gene:C6orf62_MRS2 (FusionGDB2 ID:HG81688TG57380)

Fusion Gene Summary for C6orf62_MRS2

Fusion gene summary

Fusion gene information	Fusion gene name: C6orf62_MRS2
	Fusion gene ID: hg81688tg57380
		Hgene	Tgene
	Gene symbol	C6orf62	MRS2
	Gene ID	81688	57380
	Gene name	chromosome 6 open reading frame 62	magnesium transporter MRS2
	Synonyms	Nbla00237\|XTP12\|dJ30M3.2	HPT\|MRS2L
	Cytomap	6p22.3	6p22.3
	Type of gene	protein-coding	protein-coding
	Description	uncharacterized protein C6orf62HBV X-transactivated gene 12 proteinHBV X-transactivated protein 12HBV XAg-transactivated protein 12	magnesium transporter MRS2 homolog, mitochondrialMRS2, magnesium transporterMRS2-like proteinMRS2-like, magnesium homeostasis factorputative magnesium transporter
	Modification date	20240403	20240403
	UniProtAcc	.	.
	Ensembl transtripts involved in fusion gene	ENST00000378102, ENST00000378119, ENST00000540769,	ENST00000378102, ENST00000378119, ENST00000540769,
Fusion gene scores	* DoF score	* DoF score (Degree of Frequency) = # partners X # break points X # disease types 7 X 13 X 8=728	* DoF score (Degree of Frequency) = # partners X # break points X # disease types 3 X 20 X 5=300
	# samples	27	105
	** MAII score	** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score10) log2(27/72810)=-1.43097904314787 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score10) log2(105/30010)=1.8073549220576 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0
Context	PubMed: C6orf62 [Title/Abstract] AND MRS2 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	C6orf62(24714545)-MRS2(24423811), # samples:1

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Fusion Gene Breakpoints for C6orf62_MRS2

RNA-seq based exon junction arranged fusion gene breakpoints from 8 resources (TCGA, CCLE, cBioPortal, GenBank, ChimerDB, ChimerKB, ChildHoodFusions, and GTEx). For the expressed sample information, go to Fusion Gene Sample section.

Hgene	Hchr	Hbp	Tgene	Tchr	Tbp
C6orf62	chr6	24714545	MRS2	chr6	24714545
C6orf62	chr6	24714546	MRS2	chr6	24423812
C6ORF62	chr6	24714318	MRS2	chr6	24423584

DNA-seq based exon junction arranged fusion gene breakpoints from dbVar. For the expressed sample information, go to Fusion Gene Sample section.

Hgene

Hchr

Hbp

Tgene

Tchr

Tbp

SV type

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Tumorigenic MoA (Mechanism of Action) Scenarios of Fusion Genes for C6orf62_MRS2

To generate these tumorigenic scenario annotations, we implemented a deduction-first, retrieval-later computational framework. The pipeline first applies rule-guided reasoning across ten core mechanistic categories (M1–M10) derived from fusion gene biology to infer candidate mechanisms, tumorigenic scenarios, targeting points, and targeting backgrounds. To ensure empirical accountability, a governed Python workflow retrieves literature candidates via NCBI E-utilities and Europe PMC using tiered searches. Using JSON Schema-constrained LLM evidence judges (GPT-5.6 Luna and Terra), retrieved articles are evaluated for specificity and confidence without de novo PMID generation. This produces two distinct versions: a strict version restricted to high- or medium-confidence fusion-specific evidence, and an extended version incorporating broader gene-, pathway-, and contextual evidence.

* We have 10 tumorigenic mechanism categories of fusion genes as shown below.

Constitutively Active Kinases, Catalytic Domain Dysregulation, & Transmembrane Ligand Fusions	Aberrant Chimeric Transcription Factor / Fusion Transcription Factor Activity	Epigenetic Reprogramming / Histone Modifier Dysregulation	Chromatin Remodeling Dysregulation	Condensate-Driven Transcriptional Rewiring / LLP	Promoter / Enhancer Hijacking	Dominant-Negative Antagonism	Cell Cycle / Checkpoint Bypass / RNA Processing Dysregulation	Subcellular Mislocalization / Spatial Dysregulation	Nuclear Body / Sub-organellar Architecture Disruption & Differentiation Blockade

* Strict version: Restricted to high- or medium-confidence fusion-specific evidence.

Fusion Gene Name

Mechanism Category

Mechanism PubMed

Tumorigenic Scenarios

Tumorigenic Scenario PubMed

Targeting Points

Targeting PubMed

Mechanism Background

Mechanism Background PubMed

* Extended version: Includes all strict-level fusion evidence plus broader gene-, pathway-, and low-confidence contextual evidence.

Fusion Gene Name

Mechanism Category

Mechanism PubMed

Tumorigenic Scenarios

Tumorigenic Scenario PubMed

Targeting Points

Targeting PubMed

Mechanism Background

Mechanism Background PubMed

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

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Fusion Genomic Features for C6orf62_MRS2

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence) of In-frame fusion genes. FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
C6orf62	chr6	24714545	-	MRS2	chr6	24423811	+	4.99e-05	1.00e+00

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence) of 5UTR-3CSD fusion genes (N-truncated cases).

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence) of 5CDS-3UTR fusion genes (C-truncated cases).

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of six genomic regulatory feature tracks across a ±5 kb window centered on the fusion breakpoints. We input the breakpoint sequences into AlphaGenome and obtained predicted genome tracks at single-base-pair resolution for each modality by running a single forward pass over the reference sequence. Specifically, for each breakpoint, AlphaGenome processed and returned predicted track data across diverse modalities, which were then averaged across all tracks within each output type and visualized across the ±5 kb window. The left panel shows the 5'-gene breakpoint ±5 kb area, and the right panel shows the 3'-gene breakpoint area, with tracks grouped by category: chromatin accessibility (DNase-seq, ATAC-seq), active transcription (RNA-seq, CAGE), and chromatin binding (ChIP-Histone, ChIP-TF).

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Fusion Gene ORF Annotations for C6orf62_MRS2

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-3UTR	ENST00000378102	ENST00000274747	C6orf62	chr6	24714545	-	MRS2	chr6	24423811	+
5CDS-3UTR	ENST00000378102	ENST00000535061	C6orf62	chr6	24714545	-	MRS2	chr6	24423811	+
5CDS-3UTR	ENST00000378102	ENST00000543597	C6orf62	chr6	24714545	-	MRS2	chr6	24423811	+
5CDS-3UTR	ENST00000378119	ENST00000274747	C6orf62	chr6	24714545	-	MRS2	chr6	24423811	+
5CDS-3UTR	ENST00000378119	ENST00000535061	C6orf62	chr6	24714545	-	MRS2	chr6	24423811	+
5CDS-3UTR	ENST00000378119	ENST00000543597	C6orf62	chr6	24714545	-	MRS2	chr6	24423811	+
5CDS-3UTR	ENST00000540769	ENST00000274747	C6orf62	chr6	24714545	-	MRS2	chr6	24423811	+
5CDS-3UTR	ENST00000540769	ENST00000535061	C6orf62	chr6	24714545	-	MRS2	chr6	24423811	+
5CDS-3UTR	ENST00000540769	ENST00000543597	C6orf62	chr6	24714545	-	MRS2	chr6	24423811	+

ORFfinder Result Based On The Fusion Transcript Sequences of the In-frame Fusion Genes.

Henst

Tenst

Hgene

Hchr

Hbp

Tgene

Tchr

Tbp

Seq length
(transcript)

Seq length
(peptide)

ORFfinder Result Based On The Fusion Transcript Sequences of the 5UTR-3CDS Fusion Genes for N-Truncated Protein Search.

Henst

Tenst

Hgene

Hchr

Hbp

Tgene

Tchr

Tbp

Seq length
(transcript)

Seq length
(peptide)

ORFfinder Result Based On The Fusion Transcript Sequences of the 5CDS-3UTR Fusion Genes for C-Truncated Protein Search.

Henst

Tenst

Hgene

Hchr

Hbp

Tgene

Tchr

Tbp

Seq length
(transcript)

Seq length
(peptide)

DeepORF Prediction of The Coding Potential Based on The Fusion Transcript Sequence of In-frame Fusion Genes. DeepORF is a Coding Potential Classifier Based on Convolutional Neural Network by Comparing the Real Ribo-seq Data. If the No-coding Score < 0.5 and Coding Score > 0.5, Then The In-frame Fusion Transcript is Predicted as Being Likely Translated.

Henst

Tenst

Hgene

Hchr

Hbp

Tgene

Tchr

Tbp

No-coding score

Coding score

DeepORF Prediction of The Coding Potential Based on The Fusion Transcript Sequence of 5UTR-3CDS Fusion Genes (Potential N-Truncated Proteins).

Henst

Tenst

Hgene

Hchr

Hbp

Tgene

Tchr

Tbp

No-coding score

Coding score

DeepORF Prediction of The Coding Potential Based on The Fusion Transcript Sequence of 5CDS-3UTR Fusion Genes (Potential C-Truncated Proteins).

Henst	Tenst	Hgene	Hchr	Hbp	Tgene	Tchr	Tbp	No-coding score	Coding score
ENST00000378102	ENST00000274747	C6orf62	chr6	24714545	MRS2	chr6	24423811	0.00e+00	8.20e-01
ENST00000378102	ENST00000535061	C6orf62	chr6	24714545	MRS2	chr6	24423811	0.00e+00	4.29e-02
ENST00000378102	ENST00000543597	C6orf62	chr6	24714545	MRS2	chr6	24423811	0.00e+00	4.29e-02
ENST00000378119	ENST00000274747	C6orf62	chr6	24714545	MRS2	chr6	24423811	0.00e+00	9.30e-01
ENST00000378119	ENST00000535061	C6orf62	chr6	24714545	MRS2	chr6	24423811	0.00e+00	2.72e-02
ENST00000378119	ENST00000543597	C6orf62	chr6	24714545	MRS2	chr6	24423811	0.00e+00	2.40e-02
ENST00000540769	ENST00000274747	C6orf62	chr6	24714545	MRS2	chr6	24423811	0.00e+00	9.28e-02
ENST00000540769	ENST00000535061	C6orf62	chr6	24714545	MRS2	chr6	24423811	0.00e+00	2.83e-02
ENST00000540769	ENST00000543597	C6orf62	chr6	24714545	MRS2	chr6	24423811	0.00e+00	3.37e-02

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Fusion Protein Retained/Non-Retained Functional Features for C6orf62_MRS2

Protein Level Annotation from FGviewer
* Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at download page. Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features (visualization across fusion protein length).

No matching images found for ${hg}_${tg}.

- In-frame and retained protein feature among the 13 regional features (texts).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- Retained PPIs in in-frame fusion.

Partner

Hgene

Hbp

Tgene

Tbp

ENST

UniProt

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Hgene

Hbp

Tgene

Tbp

ENST

UniProt

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Fusion Transcript Sequence for C6orf62_MRS2

In-frame Fusion Transcript Sequences.

N-Truncated Transcript (5UTR-3CDS) Sequences

C-Truncated Transcript (5CDS-3UTR) Sequences

>C6orf62_MRS2_ENST00000378102_ENST00000274747_24714545_24423811 length=439nt 
 Breakpoint=439nt
ATATTAACACAATTATTTTCTTTTTTTCCCCCACTGAACCTTCCCATTTACCCTCTCCCGCCCACTCCACCCGGGCGGGAATTGTTTCCACGATGAAATGAGTGAAAACCTGAGTGATCCTGTGTCTCCCGTGGTGCGAAAGAAAAAGTC
AGCACTTTTTGAAGTGTCTGAGGTTATACCAGTCATGACAAATAATTATGAAGAAAATATCCTGAAAGGTGTGCGAGATTCCAGCTATTCCTTGGAAAGTTCCCTAGAGCTTTTACAGAAGGATGTGGTACAGCTCCATGCTCCTCGATA
TCAGTCTATGAGAAGGGATGTAATTGGCTGTACTCAGGAGATGGATTTCATTCTTTGGCCTCGGAATGATATTGAAAAAATCGTCTGTCTCCTGTTTTCTAGGTGGAAAGAATCTGATGAGCCTTTTAGGCCTGTTCAG

>C6orf62_MRS2_ENST00000378102_ENST00000535061_24714545_24423811 length=879nt 
 Breakpoint=439nt
ATATTAACACAATTATTTTCTTTTTTTCCCCCACTGAACCTTCCCATTTACCCTCTCCCGCCCACTCCACCCGGGCGGGAATTGTTTCCACGATGAAATGAGTGAAAACCTGAGTGATCCTGTGTCTCCCGTGGTGCGAAAGAAAAAGTC
AGCACTTTTTGAAGTGTCTGAGGTTATACCAGTCATGACAAATAATTATGAAGAAAATATCCTGAAAGGTGTGCGAGATTCCAGCTATTCCTTGGAAAGTTCCCTAGAGCTTTTACAGAAGGATGTGGTACAGCTCCATGCTCCTCGATA
TCAGTCTATGAGAAGGGATGTAATTGGCTGTACTCAGGAGATGGATTTCATTCTTTGGCCTCGGAATGATATTGAAAAAATCGTCTGTCTCCTGTTTTCTAGGTGGAAAGAATCTGATGAGCCTTTTAGGCCTGTTCAGATGGCTTCTTT
ACCTAAAAAGACTCTTCTGGCAGATAGAAGCATGGAATTGAAAAATAGCCTCAGACTGGATGGACTTGGATCAGGAAGGAGCATCCTAACAAACCGTTAGGAACAGCCCCGTGGATACTGAAGTTTTTTTTATGGTAGTTACAGGAAACT
TCTGATACTCTTTTTATTATTTTCTTGTATAGAGTCAGACACTTGAAAAAAACTAATGTTTGAAGACAAAAATATTTTGGCAGTCACAATACCAGAACTGGATTGCATTTCCAGAATTCTGAGTTAAAGAAACAAAGTATTTGCTTTGTA
AAAGGCCAAAATTCTATTTCCTACAAACTTTAAATGCTGTTTTTATAGATGTGATATGAGGCAACACAAGCACAGACAGTTGCATAGATTTTAATTTATACATATCAAGAAAAGTGCAATTTCATGCTG

>C6orf62_MRS2_ENST00000378102_ENST00000543597_24714545_24423811 length=750nt 
 Breakpoint=439nt
ATATTAACACAATTATTTTCTTTTTTTCCCCCACTGAACCTTCCCATTTACCCTCTCCCGCCCACTCCACCCGGGCGGGAATTGTTTCCACGATGAAATGAGTGAAAACCTGAGTGATCCTGTGTCTCCCGTGGTGCGAAAGAAAAAGTC
AGCACTTTTTGAAGTGTCTGAGGTTATACCAGTCATGACAAATAATTATGAAGAAAATATCCTGAAAGGTGTGCGAGATTCCAGCTATTCCTTGGAAAGTTCCCTAGAGCTTTTACAGAAGGATGTGGTACAGCTCCATGCTCCTCGATA
TCAGTCTATGAGAAGGGATGTAATTGGCTGTACTCAGGAGATGGATTTCATTCTTTGGCCTCGGAATGATATTGAAAAAATCGTCTGTCTCCTGTTTTCTAGGTGGAAAGAATCTGATGAGCCTTTTAGGCCTGTTCAGATGGCTTCTTT
ACCTAAAAAGACTCTTCTGGCAGATAGAAGCATGGAATTGAAAAATAGCCTCAGACTGGATGGACTTGGATCAGGAAGGAGCATCCTAACAAACCGTTAGGAACAGCCCCGTGGATACTGAAGTTTTTTTTATGGTAGTTACAGGAAACT
TCTGATACTCTTTTTATTATTTTCTTGTATAGAGTCAGACACTTGAAAAAAACTAATGTTTGAAGACAAAAATATTTTGGCAGTCACAATACCAGAACTGGATTGCATTTCCAGAATTCTGAGTTAAAGAAACAAAGTATTTGCTTTGTA


>C6orf62_MRS2_ENST00000378119_ENST00000274747_24714545_24423811 length=2597nt 
 Breakpoint=2597nt
AAACGCGACTCTGCCCCGGACCCGCGAGGCGCCCGAGGCCTTCGCCGCTTCTGCAGCCACCGGCGGGGGGGGGAACGAGGCAGTACTGCCGCGGACGCTCACCAACCGCTTCGGCTTTTCCCCCCTCCGGGTCTCCTCGACCTTTCCTGA
GAGCCGGAATCCGACTGTAGGGGGAAGAAAGACTCAAGAGCAGATGCTTGAACTGAAATAACTTTATTTTGGGGGGTTACTTTGCTGACCCTTAGCGCAGGGCTTCCTTTCCCTTCCCCCTCCGCCGCCAGTACCAATCCAACTCCCCAT
CTTTCTCTTTGTTTTTCCTCTTTTTCTTTTTCTCTCCCTGTTGCCGCTGTCTCCGCGTCCTTCCCCTCCGTTGCCGCCCAGGGCGCCGAGCCAGACTATGGGTCCCAGGTGGGGGCTGAGCGGCGGCAGCAGCGCGGGCGGTCCAGTCAC
GGTGCGCACTGCAGCGGGGATGGAGGGGCTCAGTTGGCTGGTGGTTTTCTCTTGACATGGCTCCTGCCCGTGCTACCAGCAGCGCCCCCGCCGCCGCCGCCTCTTCCGCCGCCGCCACCGCTCCGCCCGCAGGCTGCGGCTAGAGGGCCC
AAACCCCGCCCTAGAGTCGGTCCGTGAGTCCCGGGCTCCGCGGGGACAGGGAGGGGATTTCCCCGTCACCCACCCCGCCCTAGCTGCCTCAATTCCACCCCCTGCCCCTCGGGAAACAACTAACGACCCCACCCTAAACAATCCAAACTC
TGGAAACATGGTCTGTTCAACGTGAGAGAGAGCTAATCCGGGAACTTAATTTTTTGGGGGGAGGGTGGGTGGGCTTACTTTAGAAGTAATATTAACACAATTATTTTCTTTTTTTCCCCCACTGAACCTTCCCATTTACCCTCTCCCGCC
CACTCCACCCGGGCGGGAATTGTTTCCACGATGAAATGAGTGAAAACCTGAGTGATCCTGTGTCTCCCGTGGTGCGAGTGAGTCGCTGCCGCTGAAGGCAAGGGGTGGGGGTGGGACCTGCGGGGGTGGAAGGCAGGTGGTCTCCGGGCA
CCGCCTGGGATTTGGGAGAAGAACCCGCCACCTTTGCCTCGGCAATGCTCACAAGAAGATAAATCGCACTCCCCACCATTTTGAACGGGGGCAGATCCACAGGGAAGTCTCCCTTGGGGAATGTAGGACTAGTTGCAGGCTGGGGGTGTT
GGGAACCCGGGCATTAATCAGGTCTAACCACAGAGCCGGAATAATTAATACCGTATTATATACCCCTTTTCCTTCTGCCGTCATGATTCTCCTTGGCAGCAGCGTTAGCAGCCGCCTGAGGGTGAAAATGTGGGTGATGGGGAAGTTGGT
AATGACTCCGCTGTTTTTTCTCATGGCTCCTTTGGGCCACAGCTGCCCGCCCCCGGTATACACTGTAGTTGATTGCAGGGAAACCCTGTACCTCTCCCTTTCCTTCTCTACCGATTTTGCACTTTTCTCTATGCTCACCACCAAGTGTAA
TCAATAACAAGCACTGACAATACATAGCAATAGTGAAATCTGAAATAACTAAGAATTAGGTACTACAGCCATGGAGCTGGCTGGGTAAAATCTAATTGGATATTTCAGTTTCATTCACCTACCCTGTTTTGGTGTTTGGTTTTGGTTTTG
GTTTTGGTGAGTTTTTTTTTTTTTTTTTTTTGGAAAGCAAGGATCACACTTCCCCCTCCCTGTTCCTTAATCCCTTTTCTAAAAAGGGGGGAAAATCCGGATGGATTTTAGGGATTGGTCTGGTGTCAGCTGTGTTTTATTGCACACCTA
AATCCTGATTATAGGCTTTTCATTTCTCCGCAAAGCCTTTATTTTGGCAGTTAAGCCAAATGTGTTTTCCAGAAAGTTAGTTATTTTCTCCTCTTTCTTTCCTTTCTTTCCTCCCTTTTTCCCGTCTGACCCCAAACGTTATTGTCCAAA
CATGACTGGACAGCAGCTTTTGTTTCTTGACCCTGTAATATGACAGTCTGCTAATATTGACAGAAGGTGCAGTTTTTGGGTTATAGTCGTGATTTTCGCTAATCAATCATATTAGCAGGAAAAAAAATGACTTGTTTCTGTTGTACTTGA
GTCTTAAGAAAAAGTGCCCATAGTTTAGTGACAATTTCCAAAGGCTTTAGTACCACCTGTATTTCAAAATGGGGGACCCAAACTCCCGGAAGAAACAAGCTCTGAACAGACTACGTGCTCAGCTTAGAAAGAAAAAAGAATCTCTAGCTG
ACCAGTTTGACTTCAAGATGTATATTGCCTTTGTATTCAAGGAGAAGAAGAAAAAGTCAGCACTTTTTGAAGTGTCTGAGGTTATACCAGTCATGACAAATAATTATGAAGAAAATATCCTGAAAGGTGTGCGAGATTCCAGCTATTCCT
TGGAAAGTTCCCTAGAGCTTTTACAGAAGGATGTGGTACAGCTCCATGCTCCTCGATATCAGTCTATGAGAAGGGATGTAATTGGCTGTACTCAGGAGATGGATTTCATTCTTTGGCCTCGGAATGATATTGAAAAAATCGTCTGTCTCC
TGTTTTCTAGGTGGAAAGAATCTGATGAGCCTTTTAGGCCTGTTCAG

>C6orf62_MRS2_ENST00000378119_ENST00000535061_24714545_24423811 length=3037nt 
 Breakpoint=2597nt
AAACGCGACTCTGCCCCGGACCCGCGAGGCGCCCGAGGCCTTCGCCGCTTCTGCAGCCACCGGCGGGGGGGGGAACGAGGCAGTACTGCCGCGGACGCTCACCAACCGCTTCGGCTTTTCCCCCCTCCGGGTCTCCTCGACCTTTCCTGA
GAGCCGGAATCCGACTGTAGGGGGAAGAAAGACTCAAGAGCAGATGCTTGAACTGAAATAACTTTATTTTGGGGGGTTACTTTGCTGACCCTTAGCGCAGGGCTTCCTTTCCCTTCCCCCTCCGCCGCCAGTACCAATCCAACTCCCCAT
CTTTCTCTTTGTTTTTCCTCTTTTTCTTTTTCTCTCCCTGTTGCCGCTGTCTCCGCGTCCTTCCCCTCCGTTGCCGCCCAGGGCGCCGAGCCAGACTATGGGTCCCAGGTGGGGGCTGAGCGGCGGCAGCAGCGCGGGCGGTCCAGTCAC
GGTGCGCACTGCAGCGGGGATGGAGGGGCTCAGTTGGCTGGTGGTTTTCTCTTGACATGGCTCCTGCCCGTGCTACCAGCAGCGCCCCCGCCGCCGCCGCCTCTTCCGCCGCCGCCACCGCTCCGCCCGCAGGCTGCGGCTAGAGGGCCC
AAACCCCGCCCTAGAGTCGGTCCGTGAGTCCCGGGCTCCGCGGGGACAGGGAGGGGATTTCCCCGTCACCCACCCCGCCCTAGCTGCCTCAATTCCACCCCCTGCCCCTCGGGAAACAACTAACGACCCCACCCTAAACAATCCAAACTC
TGGAAACATGGTCTGTTCAACGTGAGAGAGAGCTAATCCGGGAACTTAATTTTTTGGGGGGAGGGTGGGTGGGCTTACTTTAGAAGTAATATTAACACAATTATTTTCTTTTTTTCCCCCACTGAACCTTCCCATTTACCCTCTCCCGCC
CACTCCACCCGGGCGGGAATTGTTTCCACGATGAAATGAGTGAAAACCTGAGTGATCCTGTGTCTCCCGTGGTGCGAGTGAGTCGCTGCCGCTGAAGGCAAGGGGTGGGGGTGGGACCTGCGGGGGTGGAAGGCAGGTGGTCTCCGGGCA
CCGCCTGGGATTTGGGAGAAGAACCCGCCACCTTTGCCTCGGCAATGCTCACAAGAAGATAAATCGCACTCCCCACCATTTTGAACGGGGGCAGATCCACAGGGAAGTCTCCCTTGGGGAATGTAGGACTAGTTGCAGGCTGGGGGTGTT
GGGAACCCGGGCATTAATCAGGTCTAACCACAGAGCCGGAATAATTAATACCGTATTATATACCCCTTTTCCTTCTGCCGTCATGATTCTCCTTGGCAGCAGCGTTAGCAGCCGCCTGAGGGTGAAAATGTGGGTGATGGGGAAGTTGGT
AATGACTCCGCTGTTTTTTCTCATGGCTCCTTTGGGCCACAGCTGCCCGCCCCCGGTATACACTGTAGTTGATTGCAGGGAAACCCTGTACCTCTCCCTTTCCTTCTCTACCGATTTTGCACTTTTCTCTATGCTCACCACCAAGTGTAA
TCAATAACAAGCACTGACAATACATAGCAATAGTGAAATCTGAAATAACTAAGAATTAGGTACTACAGCCATGGAGCTGGCTGGGTAAAATCTAATTGGATATTTCAGTTTCATTCACCTACCCTGTTTTGGTGTTTGGTTTTGGTTTTG
GTTTTGGTGAGTTTTTTTTTTTTTTTTTTTTGGAAAGCAAGGATCACACTTCCCCCTCCCTGTTCCTTAATCCCTTTTCTAAAAAGGGGGGAAAATCCGGATGGATTTTAGGGATTGGTCTGGTGTCAGCTGTGTTTTATTGCACACCTA
AATCCTGATTATAGGCTTTTCATTTCTCCGCAAAGCCTTTATTTTGGCAGTTAAGCCAAATGTGTTTTCCAGAAAGTTAGTTATTTTCTCCTCTTTCTTTCCTTTCTTTCCTCCCTTTTTCCCGTCTGACCCCAAACGTTATTGTCCAAA
CATGACTGGACAGCAGCTTTTGTTTCTTGACCCTGTAATATGACAGTCTGCTAATATTGACAGAAGGTGCAGTTTTTGGGTTATAGTCGTGATTTTCGCTAATCAATCATATTAGCAGGAAAAAAAATGACTTGTTTCTGTTGTACTTGA
GTCTTAAGAAAAAGTGCCCATAGTTTAGTGACAATTTCCAAAGGCTTTAGTACCACCTGTATTTCAAAATGGGGGACCCAAACTCCCGGAAGAAACAAGCTCTGAACAGACTACGTGCTCAGCTTAGAAAGAAAAAAGAATCTCTAGCTG
ACCAGTTTGACTTCAAGATGTATATTGCCTTTGTATTCAAGGAGAAGAAGAAAAAGTCAGCACTTTTTGAAGTGTCTGAGGTTATACCAGTCATGACAAATAATTATGAAGAAAATATCCTGAAAGGTGTGCGAGATTCCAGCTATTCCT
TGGAAAGTTCCCTAGAGCTTTTACAGAAGGATGTGGTACAGCTCCATGCTCCTCGATATCAGTCTATGAGAAGGGATGTAATTGGCTGTACTCAGGAGATGGATTTCATTCTTTGGCCTCGGAATGATATTGAAAAAATCGTCTGTCTCC
TGTTTTCTAGGTGGAAAGAATCTGATGAGCCTTTTAGGCCTGTTCAGATGGCTTCTTTACCTAAAAAGACTCTTCTGGCAGATAGAAGCATGGAATTGAAAAATAGCCTCAGACTGGATGGACTTGGATCAGGAAGGAGCATCCTAACAA
ACCGTTAGGAACAGCCCCGTGGATACTGAAGTTTTTTTTATGGTAGTTACAGGAAACTTCTGATACTCTTTTTATTATTTTCTTGTATAGAGTCAGACACTTGAAAAAAACTAATGTTTGAAGACAAAAATATTTTGGCAGTCACAATAC
CAGAACTGGATTGCATTTCCAGAATTCTGAGTTAAAGAAACAAAGTATTTGCTTTGTAAAAGGCCAAAATTCTATTTCCTACAAACTTTAAATGCTGTTTTTATAGATGTGATATGAGGCAACACAAGCACAGACAGTTGCATAGATTTT
AATTTATACATATCAAGAAAAGTGCAATTTCATGCTG

>C6orf62_MRS2_ENST00000378119_ENST00000543597_24714545_24423811 length=2908nt 
 Breakpoint=2597nt
AAACGCGACTCTGCCCCGGACCCGCGAGGCGCCCGAGGCCTTCGCCGCTTCTGCAGCCACCGGCGGGGGGGGGAACGAGGCAGTACTGCCGCGGACGCTCACCAACCGCTTCGGCTTTTCCCCCCTCCGGGTCTCCTCGACCTTTCCTGA
GAGCCGGAATCCGACTGTAGGGGGAAGAAAGACTCAAGAGCAGATGCTTGAACTGAAATAACTTTATTTTGGGGGGTTACTTTGCTGACCCTTAGCGCAGGGCTTCCTTTCCCTTCCCCCTCCGCCGCCAGTACCAATCCAACTCCCCAT
CTTTCTCTTTGTTTTTCCTCTTTTTCTTTTTCTCTCCCTGTTGCCGCTGTCTCCGCGTCCTTCCCCTCCGTTGCCGCCCAGGGCGCCGAGCCAGACTATGGGTCCCAGGTGGGGGCTGAGCGGCGGCAGCAGCGCGGGCGGTCCAGTCAC
GGTGCGCACTGCAGCGGGGATGGAGGGGCTCAGTTGGCTGGTGGTTTTCTCTTGACATGGCTCCTGCCCGTGCTACCAGCAGCGCCCCCGCCGCCGCCGCCTCTTCCGCCGCCGCCACCGCTCCGCCCGCAGGCTGCGGCTAGAGGGCCC
AAACCCCGCCCTAGAGTCGGTCCGTGAGTCCCGGGCTCCGCGGGGACAGGGAGGGGATTTCCCCGTCACCCACCCCGCCCTAGCTGCCTCAATTCCACCCCCTGCCCCTCGGGAAACAACTAACGACCCCACCCTAAACAATCCAAACTC
TGGAAACATGGTCTGTTCAACGTGAGAGAGAGCTAATCCGGGAACTTAATTTTTTGGGGGGAGGGTGGGTGGGCTTACTTTAGAAGTAATATTAACACAATTATTTTCTTTTTTTCCCCCACTGAACCTTCCCATTTACCCTCTCCCGCC
CACTCCACCCGGGCGGGAATTGTTTCCACGATGAAATGAGTGAAAACCTGAGTGATCCTGTGTCTCCCGTGGTGCGAGTGAGTCGCTGCCGCTGAAGGCAAGGGGTGGGGGTGGGACCTGCGGGGGTGGAAGGCAGGTGGTCTCCGGGCA
CCGCCTGGGATTTGGGAGAAGAACCCGCCACCTTTGCCTCGGCAATGCTCACAAGAAGATAAATCGCACTCCCCACCATTTTGAACGGGGGCAGATCCACAGGGAAGTCTCCCTTGGGGAATGTAGGACTAGTTGCAGGCTGGGGGTGTT
GGGAACCCGGGCATTAATCAGGTCTAACCACAGAGCCGGAATAATTAATACCGTATTATATACCCCTTTTCCTTCTGCCGTCATGATTCTCCTTGGCAGCAGCGTTAGCAGCCGCCTGAGGGTGAAAATGTGGGTGATGGGGAAGTTGGT
AATGACTCCGCTGTTTTTTCTCATGGCTCCTTTGGGCCACAGCTGCCCGCCCCCGGTATACACTGTAGTTGATTGCAGGGAAACCCTGTACCTCTCCCTTTCCTTCTCTACCGATTTTGCACTTTTCTCTATGCTCACCACCAAGTGTAA
TCAATAACAAGCACTGACAATACATAGCAATAGTGAAATCTGAAATAACTAAGAATTAGGTACTACAGCCATGGAGCTGGCTGGGTAAAATCTAATTGGATATTTCAGTTTCATTCACCTACCCTGTTTTGGTGTTTGGTTTTGGTTTTG
GTTTTGGTGAGTTTTTTTTTTTTTTTTTTTTGGAAAGCAAGGATCACACTTCCCCCTCCCTGTTCCTTAATCCCTTTTCTAAAAAGGGGGGAAAATCCGGATGGATTTTAGGGATTGGTCTGGTGTCAGCTGTGTTTTATTGCACACCTA
AATCCTGATTATAGGCTTTTCATTTCTCCGCAAAGCCTTTATTTTGGCAGTTAAGCCAAATGTGTTTTCCAGAAAGTTAGTTATTTTCTCCTCTTTCTTTCCTTTCTTTCCTCCCTTTTTCCCGTCTGACCCCAAACGTTATTGTCCAAA
CATGACTGGACAGCAGCTTTTGTTTCTTGACCCTGTAATATGACAGTCTGCTAATATTGACAGAAGGTGCAGTTTTTGGGTTATAGTCGTGATTTTCGCTAATCAATCATATTAGCAGGAAAAAAAATGACTTGTTTCTGTTGTACTTGA
GTCTTAAGAAAAAGTGCCCATAGTTTAGTGACAATTTCCAAAGGCTTTAGTACCACCTGTATTTCAAAATGGGGGACCCAAACTCCCGGAAGAAACAAGCTCTGAACAGACTACGTGCTCAGCTTAGAAAGAAAAAAGAATCTCTAGCTG
ACCAGTTTGACTTCAAGATGTATATTGCCTTTGTATTCAAGGAGAAGAAGAAAAAGTCAGCACTTTTTGAAGTGTCTGAGGTTATACCAGTCATGACAAATAATTATGAAGAAAATATCCTGAAAGGTGTGCGAGATTCCAGCTATTCCT
TGGAAAGTTCCCTAGAGCTTTTACAGAAGGATGTGGTACAGCTCCATGCTCCTCGATATCAGTCTATGAGAAGGGATGTAATTGGCTGTACTCAGGAGATGGATTTCATTCTTTGGCCTCGGAATGATATTGAAAAAATCGTCTGTCTCC
TGTTTTCTAGGTGGAAAGAATCTGATGAGCCTTTTAGGCCTGTTCAGATGGCTTCTTTACCTAAAAAGACTCTTCTGGCAGATAGAAGCATGGAATTGAAAAATAGCCTCAGACTGGATGGACTTGGATCAGGAAGGAGCATCCTAACAA
ACCGTTAGGAACAGCCCCGTGGATACTGAAGTTTTTTTTATGGTAGTTACAGGAAACTTCTGATACTCTTTTTATTATTTTCTTGTATAGAGTCAGACACTTGAAAAAAACTAATGTTTGAAGACAAAAATATTTTGGCAGTCACAATAC
CAGAACTGGATTGCATTTCCAGAATTCTGAGTTAAAGAAACAAAGTATTTGCTTTGTA

>C6orf62_MRS2_ENST00000540769_ENST00000274747_24714545_24423811 length=475nt 
 Breakpoint=475nt
AGTCACGGTGCGCACTGCAGCGGGGATGGAGGGGCTCAGTTGGCTGGTGGTTTTCTCTTGACATGGCTCCTGCCCGTGCTACCAGCAGCGCCCCCGCCGCCGCCGCCTCTTCCGCCGCCGCCACCGCTCCGCCCGCAGGCTGCGGCTAGA
GGGCCCAAACCCCGCCCTAGAGTCGAAGAAAAAGTCAGCACTTTTTGAAGTGTCTGAGGTTATACCAGTCATGACAAATAATTATGAAGAAAATATCCTGAAAGGTGTGCGAGATTCCAGCTATTCCTTGGAAAGTTCCCTAGAGCTTTT
ACAGAAGGATGTGGTACAGCTCCATGCTCCTCGATATCAGTCTATGAGAAGGGATGTAATTGGCTGTACTCAGGAGATGGATTTCATTCTTTGGCCTCGGAATGATATTGAAAAAATCGTCTGTCTCCTGTTTTCTAGGTGGAAAGAATC
TGATGAGCCTTTTAGGCCTGTTCAG

>C6orf62_MRS2_ENST00000540769_ENST00000535061_24714545_24423811 length=915nt 
 Breakpoint=475nt
AGTCACGGTGCGCACTGCAGCGGGGATGGAGGGGCTCAGTTGGCTGGTGGTTTTCTCTTGACATGGCTCCTGCCCGTGCTACCAGCAGCGCCCCCGCCGCCGCCGCCTCTTCCGCCGCCGCCACCGCTCCGCCCGCAGGCTGCGGCTAGA
GGGCCCAAACCCCGCCCTAGAGTCGAAGAAAAAGTCAGCACTTTTTGAAGTGTCTGAGGTTATACCAGTCATGACAAATAATTATGAAGAAAATATCCTGAAAGGTGTGCGAGATTCCAGCTATTCCTTGGAAAGTTCCCTAGAGCTTTT
ACAGAAGGATGTGGTACAGCTCCATGCTCCTCGATATCAGTCTATGAGAAGGGATGTAATTGGCTGTACTCAGGAGATGGATTTCATTCTTTGGCCTCGGAATGATATTGAAAAAATCGTCTGTCTCCTGTTTTCTAGGTGGAAAGAATC
TGATGAGCCTTTTAGGCCTGTTCAGATGGCTTCTTTACCTAAAAAGACTCTTCTGGCAGATAGAAGCATGGAATTGAAAAATAGCCTCAGACTGGATGGACTTGGATCAGGAAGGAGCATCCTAACAAACCGTTAGGAACAGCCCCGTGG
ATACTGAAGTTTTTTTTATGGTAGTTACAGGAAACTTCTGATACTCTTTTTATTATTTTCTTGTATAGAGTCAGACACTTGAAAAAAACTAATGTTTGAAGACAAAAATATTTTGGCAGTCACAATACCAGAACTGGATTGCATTTCCAG
AATTCTGAGTTAAAGAAACAAAGTATTTGCTTTGTAAAAGGCCAAAATTCTATTTCCTACAAACTTTAAATGCTGTTTTTATAGATGTGATATGAGGCAACACAAGCACAGACAGTTGCATAGATTTTAATTTATACATATCAAGAAAAG
TGCAATTTCATGCTG

>C6orf62_MRS2_ENST00000540769_ENST00000543597_24714545_24423811 length=786nt 
 Breakpoint=475nt
AGTCACGGTGCGCACTGCAGCGGGGATGGAGGGGCTCAGTTGGCTGGTGGTTTTCTCTTGACATGGCTCCTGCCCGTGCTACCAGCAGCGCCCCCGCCGCCGCCGCCTCTTCCGCCGCCGCCACCGCTCCGCCCGCAGGCTGCGGCTAGA
GGGCCCAAACCCCGCCCTAGAGTCGAAGAAAAAGTCAGCACTTTTTGAAGTGTCTGAGGTTATACCAGTCATGACAAATAATTATGAAGAAAATATCCTGAAAGGTGTGCGAGATTCCAGCTATTCCTTGGAAAGTTCCCTAGAGCTTTT
ACAGAAGGATGTGGTACAGCTCCATGCTCCTCGATATCAGTCTATGAGAAGGGATGTAATTGGCTGTACTCAGGAGATGGATTTCATTCTTTGGCCTCGGAATGATATTGAAAAAATCGTCTGTCTCCTGTTTTCTAGGTGGAAAGAATC
TGATGAGCCTTTTAGGCCTGTTCAGATGGCTTCTTTACCTAAAAAGACTCTTCTGGCAGATAGAAGCATGGAATTGAAAAATAGCCTCAGACTGGATGGACTTGGATCAGGAAGGAGCATCCTAACAAACCGTTAGGAACAGCCCCGTGG
ATACTGAAGTTTTTTTTATGGTAGTTACAGGAAACTTCTGATACTCTTTTTATTATTTTCTTGTATAGAGTCAGACACTTGAAAAAAACTAATGTTTGAAGACAAAAATATTTTGGCAGTCACAATACCAGAACTGGATTGCATTTCCAG
AATTCTGAGTTAAAGAAACAAAGTATTTGCTTTGTA

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Fusion Protein Sequence for C6orf62_MRS2

In-frame Fusion Protein Sequences.

N-Truncated Protein (5UTR-3CDS) Sequences

C-Truncated Protein (5CDS-3UTR) Sequences

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Personalized Fusion Protein Sequence for C6orf62_MRS2

TCGA Kinase/DNA-binding Domain Mutated Fusion Protein Sequences

Num

Gene Group

Domain Loci

Fusion Protein ID

Fusion Gene Name

Partner

Mutated Residue in WT Protein

Seq. Length

Mutated Residue in Fusion Protein

CCLE Kinase/DNA-binding Domain Mutated Fusion Protein Sequences

Num

Gene Group

Domain Loci

Fusion Protein ID

Fusion Gene Name

Partner

Mutated Residue in WT Protein

Seq. Length

Mutated Residue in Fusion Protein

TCGA All Mutated Fusion Protein Sequences

Fusion Protein ID

Sample ID

Mutated Partner

AAchange in WT

Seq. Length

AAchange in Fusion

CCLE All Mutated Fusion Protein Sequences

Fusion Protein ID

Sample ID

Mutated Partner

AAchange in WT

Seq. Length

AAchange in Fusion

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Fusion Gene Exprssed Samples for C6orf62_MRS2

RNA-seq based fusion gene expressed samples.

Source	Study	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB		SKCM	TCGA-EE-A2GP-06A	C6orf62	chr6	24714545	-	MRS2	chr6	24714545	+
ChimerDB		SKCM	TCGA-EE-A2GP	C6orf62	chr6	24714545	-	MRS2	chr6	24714545	+
WashU		SKCM	TCGA-EE-A2GP-06A	C6orf62	chr6	24714546	-	MRS2	chr6	24423812	+
cBioPortal	SKCM_TCGA_PAN_CAN_ATLAS_2018	SKCM	TCGA-EE-A2GP-06	C6ORF62	chr6	24714318		MRS2	chr6	24423584

DNA-seq based fusion gene expressed samples.

Source

Study

Disease

Sample

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

SV type

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Related Drugs for C6orf62_MRS2

PubMed Abstract Search With ['A-B' AND 'drug'], ['A::B' AND 'drug']
* For more details on the Studied, Reported, Approved Drugs targeting this fusion gene, Go to FusionPub.

PMID

Fusion Gene Name

Drug

Study Title

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status