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	Fusion Gene Summary
	Fusion Gene Breakpoints
	Tumorigenic MoA (Mechanism of Action) Scenarios of Fusion Geness
	Fusion Genomic Features
	Fusion Gene ORF Annotations
	Fusion Protein Retained/Non-Retained Functional Features
	Fusion Transcript Sequences
	Fusion Protein Sequences
	Personalized Fusion Protein Sequences
	Fusion Gene Expressed Samples
	Related Drugs

Fusion gene:ADAMTS12_C1QTNF3 (FusionGDB2 ID:HG81792TG114899)

Fusion Gene Summary for ADAMTS12_C1QTNF3

Fusion gene summary

Fusion gene information	Fusion gene name: ADAMTS12_C1QTNF3
	Fusion gene ID: hg81792tg114899
		Hgene	Tgene
	Gene symbol	ADAMTS12	C1QTNF3
	Gene ID	81792	114899
	Gene name	ADAM metallopeptidase with thrombospondin type 1 motif 12	C1q and TNF related 3
	Synonyms	PRO4389	C1ATNF3\|CORCS\|CORS\|CORS-26\|CORS26\|CTRP3
	Cytomap	5p13.3-p13.2	5p13.2
	Type of gene	protein-coding	protein-coding
	Description	A disintegrin and metalloproteinase with thrombospondin motifs 12ADAM-TS 12ADAM-TS12ADAMTS-12a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 12	complement C1q tumor necrosis factor-related protein 3C1q and tumor necrosis factor related protein 3cartonectincollagenous repeat-containing sequence 26 kDa proteincollagenous repeat-containing sequence of 26-kDasecretory protein CORS26
	Modification date	20240305	20240407
	UniProtAcc	.	.
	Ensembl transtripts involved in fusion gene	ENST00000352040, ENST00000504830, ENST00000515401, ENST00000504582,
Fusion gene scores	* DoF score	* DoF score (Degree of Frequency) = # partners X # break points X # disease types 5 X 10 X 4=200	* DoF score (Degree of Frequency) = # partners X # break points X # disease types 7 X 4 X 12=336
	# samples	6	15
	** MAII score	** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score10) log2(6/20010)=-1.73696559416621 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score10) log2(15/33610)=-1.16349873228288 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: ADAMTS12 [Title/Abstract] AND C1QTNF3 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	ADAMTS12(33891834)-C1QTNF3(34035863), # samples:1

Fusion gene breakpoints across ADAMTS12 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across C1QTNF3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Breakpoints for ADAMTS12_C1QTNF3

RNA-seq based exon junction arranged fusion gene breakpoints from 8 resources (TCGA, CCLE, cBioPortal, GenBank, ChimerDB, ChimerKB, ChildHoodFusions, and GTEx). For the expressed sample information, go to Fusion Gene Sample section.

Hgene	Hchr	Hbp	Tgene	Tchr	Tbp
ADAMTS12	chr5	33891834	C1QTNF3	chr5	34035863
ADAMTS12	chr5	33891835	C1QTNF3	chr5	34035863

DNA-seq based exon junction arranged fusion gene breakpoints from dbVar. For the expressed sample information, go to Fusion Gene Sample section.

Hgene	Hchr	Hbp	Tgene	Tchr	Tbp	SV type
ADAMTS12	chr5	33561129	C1QTNF3	chr5	34043235	DEL
ADAMTS12	chr5	33824748	C1QTNF3	chr5	34032480	DUP

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Tumorigenic MoA (Mechanism of Action) Scenarios of Fusion Genes for ADAMTS12_C1QTNF3

To generate these tumorigenic scenario annotations, we implemented a deduction-first, retrieval-later computational framework. The pipeline first applies rule-guided reasoning across ten core mechanistic categories (M1–M10) derived from fusion gene biology to infer candidate mechanisms, tumorigenic scenarios, targeting points, and targeting backgrounds. To ensure empirical accountability, a governed Python workflow retrieves literature candidates via NCBI E-utilities and Europe PMC using tiered searches. Using JSON Schema-constrained LLM evidence judges (GPT-5.6 Luna and Terra), retrieved articles are evaluated for specificity and confidence without de novo PMID generation. This produces two distinct versions: a strict version restricted to high- or medium-confidence fusion-specific evidence, and an extended version incorporating broader gene-, pathway-, and contextual evidence.

* We have 10 tumorigenic mechanism categories of fusion genes as shown below.

Constitutively Active Kinases, Catalytic Domain Dysregulation, & Transmembrane Ligand Fusions	Aberrant Chimeric Transcription Factor / Fusion Transcription Factor Activity	Epigenetic Reprogramming / Histone Modifier Dysregulation	Chromatin Remodeling Dysregulation	Condensate-Driven Transcriptional Rewiring / LLP	Promoter / Enhancer Hijacking	Dominant-Negative Antagonism	Cell Cycle / Checkpoint Bypass / RNA Processing Dysregulation	Subcellular Mislocalization / Spatial Dysregulation	Nuclear Body / Sub-organellar Architecture Disruption & Differentiation Blockade

* Strict version: Restricted to high- or medium-confidence fusion-specific evidence.

Fusion Gene Name	Mechanism Category	Mechanism PubMed	Tumorigenic Scenarios	Tumorigenic Scenario PubMed	Targeting Points	Targeting PubMed	Mechanism Background	Mechanism Background PubMed
ADAMTS12-C1QTNF3	Promoter / Enhancer Hijacking M6		Promoter hijacking drives ectopic CTRP3 expression, stimulating ERK1/2 and Akt phosphorylation to inhibit apoptosis.		Akt/ERK signaling inhibitors; standard chemotherapy		Chondrosarcomas and gastrointestinal tumors

* Extended version: Includes all strict-level fusion evidence plus broader gene-, pathway-, and low-confidence contextual evidence.

Fusion Gene Name	Mechanism Category	Mechanism PubMed	Tumorigenic Scenarios	Tumorigenic Scenario PubMed	Targeting Points	Targeting PubMed	Mechanism Background	Mechanism Background PubMed
ADAMTS12-C1QTNF3	Promoter / Enhancer Hijacking M6		Promoter hijacking drives ectopic CTRP3 expression, stimulating ERK1/2 and Akt phosphorylation to inhibit apoptosis.		Akt/ERK signaling inhibitors; standard chemotherapy		Chondrosarcomas and gastrointestinal tumors	Evidence level: Limited indirect gene evidence; Confidence: Low; PMID: 31204077; Title: Genes associated with bowel metastases in ovarian cancer.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	ADAMTS12	GO:0030167	proteoglycan catabolic process	17895370
Hgene	ADAMTS12	GO:0032331	negative regulation of chondrocyte differentiation	22247065
Hgene	ADAMTS12	GO:0050727	regulation of inflammatory response	23019333
Hgene	ADAMTS12	GO:0051603	proteolysis involved in protein catabolic process	16611630
Hgene	ADAMTS12	GO:0071773	cellular response to BMP stimulus	22247065
Hgene	ADAMTS12	GO:1901509	regulation of endothelial tube morphogenesis	17895370
Hgene	ADAMTS12	GO:1902203	negative regulation of hepatocyte growth factor receptor signaling pathway	17895370
Hgene	ADAMTS12	GO:1902548	negative regulation of cellular response to vascular endothelial growth factor stimulus	17895370
Hgene	ADAMTS12	GO:2001113	negative regulation of cellular response to hepatocyte growth factor stimulus	17895370
Tgene	C1QTNF3	GO:0001819	positive regulation of cytokine production	18421280
Tgene	C1QTNF3	GO:0032715	negative regulation of interleukin-6 production	16213490
Tgene	C1QTNF3	GO:0035356	intracellular triglyceride homeostasis	20739398
Tgene	C1QTNF3	GO:0045721	negative regulation of gluconeogenesis	20952387
Tgene	C1QTNF3	GO:0050728	negative regulation of inflammatory response	16213490
Tgene	C1QTNF3	GO:0070165	positive regulation of adiponectin secretion	18421280
Tgene	C1QTNF3	GO:0071638	negative regulation of monocyte chemotactic protein-1 production	20739398
Tgene	C1QTNF3	GO:1901223	negative regulation of non-canonical NF-kappaB signal transduction	16213490

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Fusion Genomic Features for ADAMTS12_C1QTNF3

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence) of In-frame fusion genes. FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
ADAMTS12	chr5	33891834	-	C1QTNF3	chr5	34035863	-	6.51e-06	1.00e+00

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence) of 5UTR-3CSD fusion genes (N-truncated cases).

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence) of 5CDS-3UTR fusion genes (C-truncated cases).

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of six genomic regulatory feature tracks across a ±5 kb window centered on the fusion breakpoints. We input the breakpoint sequences into AlphaGenome and obtained predicted genome tracks at single-base-pair resolution for each modality by running a single forward pass over the reference sequence. Specifically, for each breakpoint, AlphaGenome processed and returned predicted track data across diverse modalities, which were then averaged across all tracks within each output type and visualized across the ±5 kb window. The left panel shows the 5'-gene breakpoint ±5 kb area, and the right panel shows the 3'-gene breakpoint area, with tracks grouped by category: chromatin accessibility (DNase-seq, ATAC-seq), active transcription (RNA-seq, CAGE), and chromatin binding (ChIP-Histone, ChIP-TF).

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Fusion Gene ORF Annotations for ADAMTS12_C1QTNF3

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
In-frame	ENST00000352040	ENST00000231338	ADAMTS12	chr5	33891834	-	C1QTNF3	chr5	34035863	-
In-frame	ENST00000352040	ENST00000382065	ADAMTS12	chr5	33891834	-	C1QTNF3	chr5	34035863	-
In-frame	ENST00000504830	ENST00000231338	ADAMTS12	chr5	33891834	-	C1QTNF3	chr5	34035863	-
In-frame	ENST00000504830	ENST00000382065	ADAMTS12	chr5	33891834	-	C1QTNF3	chr5	34035863	-
In-frame	ENST00000515401	ENST00000231338	ADAMTS12	chr5	33891834	-	C1QTNF3	chr5	34035863	-
In-frame	ENST00000515401	ENST00000382065	ADAMTS12	chr5	33891834	-	C1QTNF3	chr5	34035863	-

ORFfinder Result Based On The Fusion Transcript Sequences of the In-frame Fusion Genes.

Henst	Tenst	Hgene	Hchr	Hbp	Tgene	Tchr	Tbp	Seq length (transcript)	Seq length (peptide)
ENST00000352040	ENST00000231338	ADAMTS12	chr5	33891834	C1QTNF3	chr5	34035863	212	252
ENST00000352040	ENST00000382065	ADAMTS12	chr5	33891834	C1QTNF3	chr5	34035863	212	252
ENST00000504830	ENST00000231338	ADAMTS12	chr5	33891834	C1QTNF3	chr5	34035863	463	252
ENST00000504830	ENST00000382065	ADAMTS12	chr5	33891834	C1QTNF3	chr5	34035863	463	1131
ENST00000515401	ENST00000231338	ADAMTS12	chr5	33891834	C1QTNF3	chr5	34035863	290	252
ENST00000515401	ENST00000382065	ADAMTS12	chr5	33891834	C1QTNF3	chr5	34035863	290	252

ORFfinder Result Based On The Fusion Transcript Sequences of the 5UTR-3CDS Fusion Genes for N-Truncated Protein Search.

Henst

Tenst

Hgene

Hchr

Hbp

Tgene

Tchr

Tbp

Seq length
(transcript)

Seq length
(peptide)

ORFfinder Result Based On The Fusion Transcript Sequences of the 5CDS-3UTR Fusion Genes for C-Truncated Protein Search.

Henst

Tenst

Hgene

Hchr

Hbp

Tgene

Tchr

Tbp

Seq length
(transcript)

Seq length
(peptide)

DeepORF Prediction of The Coding Potential Based on The Fusion Transcript Sequence of In-frame Fusion Genes. DeepORF is a Coding Potential Classifier Based on Convolutional Neural Network by Comparing the Real Ribo-seq Data. If the No-coding Score < 0.5 and Coding Score > 0.5, Then The In-frame Fusion Transcript is Predicted as Being Likely Translated.

Henst	Tenst	Hgene	Hchr	Hbp	Tgene	Tchr	Tbp	No-coding score	Coding score
ENST00000352040	ENST00000231338	ADAMTS12	chr5	33891834	C1QTNF3	chr5	34035863	2.71e-02	9.73e-01
ENST00000352040	ENST00000382065	ADAMTS12	chr5	33891834	C1QTNF3	chr5	34035863	2.81e-02	9.72e-01
ENST00000504830	ENST00000231338	ADAMTS12	chr5	33891834	C1QTNF3	chr5	34035863	2.06e-02	9.79e-01
ENST00000504830	ENST00000382065	ADAMTS12	chr5	33891834	C1QTNF3	chr5	34035863	2.13e-02	9.79e-01
ENST00000515401	ENST00000231338	ADAMTS12	chr5	33891834	C1QTNF3	chr5	34035863	2.43e-02	9.76e-01
ENST00000515401	ENST00000382065	ADAMTS12	chr5	33891834	C1QTNF3	chr5	34035863	2.52e-02	9.75e-01

DeepORF Prediction of The Coding Potential Based on The Fusion Transcript Sequence of 5UTR-3CDS Fusion Genes (Potential N-Truncated Proteins).

Henst

Tenst

Hgene

Hchr

Hbp

Tgene

Tchr

Tbp

No-coding score

Coding score

DeepORF Prediction of The Coding Potential Based on The Fusion Transcript Sequence of 5CDS-3UTR Fusion Genes (Potential C-Truncated Proteins).

Henst

Tenst

Hgene

Hchr

Hbp

Tgene

Tchr

Tbp

No-coding score

Coding score

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Fusion Protein Retained/Non-Retained Functional Features for ADAMTS12_C1QTNF3

Protein Level Annotation from FGviewer
* Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at download page. Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features (visualization across fusion protein length).

ADAMTS12_C1QTNF3_chr5-33891834_chr5-34035863.png

- In-frame and retained protein feature among the 13 regional features (texts).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

C1QTNF3

chr5:33891834

chr5:34035863

ENST00000231338

Q9BXJ4

55_64

28.0

247.0

Compositional bias

Pro residues

Tgene

C1QTNF3

chr5:33891834

chr5:34035863

ENST00000231338

Q9BXJ4

65_74

28.0

247.0

Compositional bias

Low complexity

Tgene

C1QTNF3

chr5:33891834

chr5:34035863

ENST00000231338

Q9BXJ4

80_107

28.0

247.0

Compositional bias

Basic and acidic residues

Tgene

C1QTNF3

chr5:33891834

chr5:34035863

ENST00000231338

Q9BXJ4

113_246

28.0

247.0

Domain

C1q

Tgene

C1QTNF3

chr5:33891834

chr5:34035863

ENST00000231338

Q9BXJ4

51_113

28.0

247.0

Domain

Note=Collagen-like

Tgene

C1QTNF3

chr5:33891834

chr5:34035863

ENST00000231338

Q9BXJ4

53_110

28.0

247.0

Region

Disordered

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

ADAMTS12

chr5:33891834

chr5:34035863

ENST00000352040

P58397

1018_1027

42.333333333333336

1510.0

Compositional bias

Pro residues

Hgene

ADAMTS12

chr5:33891834

chr5:34035863

ENST00000352040

P58397

1040_1057

42.333333333333336

1510.0

Compositional bias

Low complexity

Hgene

ADAMTS12

chr5:33891834

chr5:34035863

ENST00000352040

P58397

1067_1076

42.333333333333336

1510.0

Compositional bias

Polar residues

Hgene

ADAMTS12

chr5:33891834

chr5:34035863

ENST00000352040

P58397

1095_1114

42.333333333333336

1510.0

Compositional bias

Polar residues

Hgene

ADAMTS12

chr5:33891834

chr5:34035863

ENST00000352040

P58397

1117_1132

42.333333333333336

1510.0

Compositional bias

Low complexity

Hgene

ADAMTS12

chr5:33891834

chr5:34035863

ENST00000352040

P58397

1151_1163

42.333333333333336

1510.0

Compositional bias

Basic and acidic residues

Hgene

ADAMTS12

chr5:33891834

chr5:34035863

ENST00000352040

P58397

1273_1283

42.333333333333336

1510.0

Compositional bias

Polar residues

Hgene

ADAMTS12

chr5:33891834

chr5:34035863

ENST00000352040

P58397

1313_1366

42.333333333333336

1510.0

Domain

TSP type-1 5

Hgene

ADAMTS12

chr5:33891834

chr5:34035863

ENST00000352040

P58397

1368_1422

42.333333333333336

1510.0

Domain

TSP type-1 6

Hgene

ADAMTS12

chr5:33891834

chr5:34035863

ENST00000352040

P58397

1423_1471

42.333333333333336

1510.0

Domain

TSP type-1 7

Hgene

ADAMTS12

chr5:33891834

chr5:34035863

ENST00000352040

P58397

1472_1532

42.333333333333336

1510.0

Domain

TSP type-1 8

Hgene

ADAMTS12

chr5:33891834

chr5:34035863

ENST00000352040

P58397

1535_1575

42.333333333333336

1510.0

Domain

PLAC

Hgene

ADAMTS12

chr5:33891834

chr5:34035863

ENST00000352040

P58397

246_456

42.333333333333336

1510.0

Domain

Peptidase M12B

Hgene

ADAMTS12

chr5:33891834

chr5:34035863

ENST00000352040

P58397

465_544

42.333333333333336

1510.0

Domain

Note=Disintegrin

Hgene

ADAMTS12

chr5:33891834

chr5:34035863

ENST00000352040

P58397

542_597

42.333333333333336

1510.0

Domain

TSP type-1 1

Hgene

ADAMTS12

chr5:33891834

chr5:34035863

ENST00000352040

P58397

823_883

42.333333333333336

1510.0

Domain

TSP type-1 2

Hgene

ADAMTS12

chr5:33891834

chr5:34035863

ENST00000352040

P58397

887_943

42.333333333333336

1510.0

Domain

TSP type-1 3

Hgene

ADAMTS12

chr5:33891834

chr5:34035863

ENST00000352040

P58397

944_997

42.333333333333336

1510.0

Domain

TSP type-1 4

Hgene

ADAMTS12

chr5:33891834

chr5:34035863

ENST00000352040

P58397

208_213

42.333333333333336

1510.0

Motif

Cysteine switch

Hgene

ADAMTS12

chr5:33891834

chr5:34035863

ENST00000352040

P58397

1002_1076

42.333333333333336

1510.0

Region

Disordered

Hgene

ADAMTS12

chr5:33891834

chr5:34035863

ENST00000352040

P58397

1095_1174

42.333333333333336

1510.0

Region

Disordered

Hgene

ADAMTS12

chr5:33891834

chr5:34035863

ENST00000352040

P58397

1249_1283

42.333333333333336

1510.0

Region

Disordered

Hgene

ADAMTS12

chr5:33891834

chr5:34035863

ENST00000352040

P58397

701_827

42.333333333333336

1510.0

Region

Note=Spacer 1

Hgene

ADAMTS12

chr5:33891834

chr5:34035863

ENST00000352040

P58397

997_1316

42.333333333333336

1510.0

Region

Note=Spacer 2

- Retained PPIs in in-frame fusion.

Partner

Hgene

Hbp

Tgene

Tbp

ENST

UniProt

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Hgene

Hbp

Tgene

Tbp

ENST

UniProt

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Fusion Transcript Sequence for ADAMTS12_C1QTNF3

In-frame Fusion Transcript Sequences.

>ADAMTS12_C1QTNF3_ENST00000352040_ENST00000231338_33891834_34035863 length=1999nt 
 Breakpoint=212nt
TCCTGCTGGGCCACAGGCGAGCGCTTTATTTCTGGAGCTGAGGGCTAAAACTTTTTTGACTTTTCTTCTCCTCAACATCTGAATCATGCCATGTGCCCAGAGGAGCTGGCTTGCAAACCTTTCCGTGGTGGCTCAGCTCCTTAACTTTGG
GGCGCTTTGCTATGGGAGACAGCCTCAGCCAGGCCCGGTTCGCTTCCCGGACAGGAGGCAAGTCTCCACAAACCGGAGGACTACCCCCAGACTGCAGTAAGTGTTGTCATGGAGACTACAGCTTTCGAGGCTACCAAGGCCCCCCTGGGC
CACCGGGCCCTCCTGGCATTCCAGGAAACCATGGAAACAATGGCAACAATGGAGCCACTGGTCATGAAGGAGCCAAAGGTGAGAAGGGCGACAAAGGTGACCTGGGGCCTCGAGGGGAGCGGGGGCAGCATGGCCCCAAAGGAGAGAAGG
GCTACCCGGGGATTCCACCAGAACTTCAGATTGCATTCATGGCTTCTCTGGCAACCCACTTCAGCAATCAGAACAGTGGGATTATCTTCAGCAGTGTTGAGACCAACATTGGAAACTTCTTTGATGTCATGACTGGTAGATTTGGGGCCC
CAGTATCAGGTGTGTATTTCTTCACCTTCAGCATGATGAAGCATGAGGATGTTGAGGAAGTGTATGTGTACCTTATGCACAATGGCAACACAGTCTTCAGCATGTACAGCTATGAAATGAAGGGCAAATCAGATACATCCAGCAATCATG
CTGTGCTGAAGCTAGCCAAAGGGGATGAGGTTTGGCTGCGAATGGGCAATGGCGCTCTCCATGGGGACCACCAACGCTTCTCCACCTTTGCAGGATTCCTGCTCTTTGAAACTAAGTAAATATATGACTAGAATAGCTCCACTTTGGGGA
AGACTTGTAGCTGAGCTGATTTGTTACGATCTGAGGAACATTAAAGTTGAGGGTTTTACATTGCTGTATTCAAAAAATTATTGGTTGCAATGTTGTTCACGCTACAGGTACACCAATAATGTTGGACAATTCAGGGGCTCAGAAGAATCA
ACCACAAAATAGTCTTCTCAGATGACCTTGACTAATATACTCAGCATCTTTATCACTCTTTCCTTGGCACCTAAAAGATAATTCTCCTCTGACGCAGGTTGGAAATATTTTTTTCTATCACAGAAGTCATTTGCAAAGAATTTTGACTAC
TCTGCTTTTAATTTAATACCAGTTTTCAGGAACCCCTGAAGTTTTAAGTTCATTATTCTTTATAACATTTGAGAGAATCGGATGTAGTGATATGACAGGGCTGGGGCAAGAACAGGGGCACTAGCTGCCTTATTAGCTAATTTAGTGCCC
TCCGTGTTCAGCTTAGCCTTTGACCCTTTCCTTTTGATCCACAAAATACATTAAAACTCTGAATTCACATACAATGCTATTTTAAAGTCAATAGATTTTAGCTATAAAGTGCTTGACCAGTAATGTGGTTGTAATTTTGTGTATGTTCCC
CCACATCGCCCCCAACTTCGGATGTGGGGTCAGGAGGTTGAGGTTCACTATTAACAAATGTCATAAATATCTCATAGAGGTACAGTGCCAATAGATATTCAAATGTTGCATGTTGACCAGAGGGATTTTATATCTGAAGAACATACACTA
TTAATAAATACCTTAGAGAAAGATTTTGACCTGGCTTTAGATAAAACTGTGGCAAGAAAAATGTAATGAGCAATATATGGAAATAAACACACCTTTGTTAAAGATACTTTCTAAACTTGTGTTTAATAAACTTTAATAGTCATAGAATTG
TAAATCACTATGGTTAACAGAAAGTGAAAATATTTTCATGCAGATGATGTGAACAGCCATGTGAATAGGTGACTTGGGCACACAGCAGGGTCATATGACTTCAGAAAACTTCGCTTTTCAGTTATTCCATTGTTATAATGTCAACCCTTT
AAGACATTGATGTTTAGAGGGCTCACAAATAAAATCTGAATACCTGTAA

>ADAMTS12_C1QTNF3_ENST00000352040_ENST00000382065_33891834_34035863 length=2004nt 
 Breakpoint=212nt
TCCTGCTGGGCCACAGGCGAGCGCTTTATTTCTGGAGCTGAGGGCTAAAACTTTTTTGACTTTTCTTCTCCTCAACATCTGAATCATGCCATGTGCCCAGAGGAGCTGGCTTGCAAACCTTTCCGTGGTGGCTCAGCTCCTTAACTTTGG
GGCGCTTTGCTATGGGAGACAGCCTCAGCCAGGCCCGGTTCGCTTCCCGGACAGGAGGCAAGTCTCCACAAACCGGAGGACTACCCCCAGACTGCAGTAAGTGTTGTCATGGAGACTACAGCTTTCGAGGCTACCAAGGCCCCCCTGGGC
CACCGGGCCCTCCTGGCATTCCAGGAAACCATGGAAACAATGGCAACAATGGAGCCACTGGTCATGAAGGAGCCAAAGGTGAGAAGGGCGACAAAGGTGACCTGGGGCCTCGAGGGGAGCGGGGGCAGCATGGCCCCAAAGGAGAGAAGG
GCTACCCGGGGATTCCACCAGAACTTCAGATTGCATTCATGGCTTCTCTGGCAACCCACTTCAGCAATCAGAACAGTGGGATTATCTTCAGCAGTGTTGAGACCAACATTGGAAACTTCTTTGATGTCATGACTGGTAGATTTGGGGCCC
CAGTATCAGGTGTGTATTTCTTCACCTTCAGCATGATGAAGCATGAGGATGTTGAGGAAGTGTATGTGTACCTTATGCACAATGGCAACACAGTCTTCAGCATGTACAGCTATGAAATGAAGGGCAAATCAGATACATCCAGCAATCATG
CTGTGCTGAAGCTAGCCAAAGGGGATGAGGTTTGGCTGCGAATGGGCAATGGCGCTCTCCATGGGGACCACCAACGCTTCTCCACCTTTGCAGGATTCCTGCTCTTTGAAACTAAGTAAATATATGACTAGAATAGCTCCACTTTGGGGA
AGACTTGTAGCTGAGCTGATTTGTTACGATCTGAGGAACATTAAAGTTGAGGGTTTTACATTGCTGTATTCAAAAAATTATTGGTTGCAATGTTGTTCACGCTACAGGTACACCAATAATGTTGGACAATTCAGGGGCTCAGAAGAATCA
ACCACAAAATAGTCTTCTCAGATGACCTTGACTAATATACTCAGCATCTTTATCACTCTTTCCTTGGCACCTAAAAGATAATTCTCCTCTGACGCAGGTTGGAAATATTTTTTTCTATCACAGAAGTCATTTGCAAAGAATTTTGACTAC
TCTGCTTTTAATTTAATACCAGTTTTCAGGAACCCCTGAAGTTTTAAGTTCATTATTCTTTATAACATTTGAGAGAATCGGATGTAGTGATATGACAGGGCTGGGGCAAGAACAGGGGCACTAGCTGCCTTATTAGCTAATTTAGTGCCC
TCCGTGTTCAGCTTAGCCTTTGACCCTTTCCTTTTGATCCACAAAATACATTAAAACTCTGAATTCACATACAATGCTATTTTAAAGTCAATAGATTTTAGCTATAAAGTGCTTGACCAGTAATGTGGTTGTAATTTTGTGTATGTTCCC
CCACATCGCCCCCAACTTCGGATGTGGGGTCAGGAGGTTGAGGTTCACTATTAACAAATGTCATAAATATCTCATAGAGGTACAGTGCCAATAGATATTCAAATGTTGCATGTTGACCAGAGGGATTTTATATCTGAAGAACATACACTA
TTAATAAATACCTTAGAGAAAGATTTTGACCTGGCTTTAGATAAAACTGTGGCAAGAAAAATGTAATGAGCAATATATGGAAATAAACACACCTTTGTTAAAGATACTTTCTAAACTTGTGTTTAATAAACTTTAATAGTCATAGAATTG
TAAATCACTATGGTTAACAGAAAGTGAAAATATTTTCATGCAGATGATGTGAACAGCCATGTGAATAGGTGACTTGGGCACACAGCAGGGTCATATGACTTCAGAAAACTTCGCTTTTCAGTTATTCCATTGTTATAATGTCAACCCTTT
AAGACATTGATGTTTAGAGGGCTCACAAATAAAATCTGAATACCTGTAAGGAAA

>ADAMTS12_C1QTNF3_ENST00000504830_ENST00000231338_33891834_34035863 length=2250nt 
 Breakpoint=463nt
GAGCGGGCGGGCTGCGAGGCCGCGGGGCATGCGGGAGGCGGAGGGGTGGGGACCGGGGTGGGCTGCGCCCTCCCGCTCTGGCCCATTCCACACCCCGCCGAAAGCGGACACTGTCAGCTGAATCACTCCCCTTTTAGGAGGAGGGAGGGG
AAAAAGGTGTCTAGCTCCTTTCTGCTTAAAAAAGCACAGGGAGATCGCGGGCAGCTTTGCAGTCGCTGCCTTCTCGCGCCTGACCATGCACCCCTGCATCTTCCTGCTGGGCCACAGGCGAGCGCTTTATTTCTGGAGCTGAGGGCTAAA
ACTTTTTTGACTTTTCTTCTCCTCAACATCTGAATCATGCCATGTGCCCAGAGGAGCTGGCTTGCAAACCTTTCCGTGGTGGCTCAGCTCCTTAACTTTGGGGCGCTTTGCTATGGGAGACAGCCTCAGCCAGGCCCGGTTCGCTTCCCG
GACAGGAGGCAAGTCTCCACAAACCGGAGGACTACCCCCAGACTGCAGTAAGTGTTGTCATGGAGACTACAGCTTTCGAGGCTACCAAGGCCCCCCTGGGCCACCGGGCCCTCCTGGCATTCCAGGAAACCATGGAAACAATGGCAACAA
TGGAGCCACTGGTCATGAAGGAGCCAAAGGTGAGAAGGGCGACAAAGGTGACCTGGGGCCTCGAGGGGAGCGGGGGCAGCATGGCCCCAAAGGAGAGAAGGGCTACCCGGGGATTCCACCAGAACTTCAGATTGCATTCATGGCTTCTCT
GGCAACCCACTTCAGCAATCAGAACAGTGGGATTATCTTCAGCAGTGTTGAGACCAACATTGGAAACTTCTTTGATGTCATGACTGGTAGATTTGGGGCCCCAGTATCAGGTGTGTATTTCTTCACCTTCAGCATGATGAAGCATGAGGA
TGTTGAGGAAGTGTATGTGTACCTTATGCACAATGGCAACACAGTCTTCAGCATGTACAGCTATGAAATGAAGGGCAAATCAGATACATCCAGCAATCATGCTGTGCTGAAGCTAGCCAAAGGGGATGAGGTTTGGCTGCGAATGGGCAA
TGGCGCTCTCCATGGGGACCACCAACGCTTCTCCACCTTTGCAGGATTCCTGCTCTTTGAAACTAAGTAAATATATGACTAGAATAGCTCCACTTTGGGGAAGACTTGTAGCTGAGCTGATTTGTTACGATCTGAGGAACATTAAAGTTG
AGGGTTTTACATTGCTGTATTCAAAAAATTATTGGTTGCAATGTTGTTCACGCTACAGGTACACCAATAATGTTGGACAATTCAGGGGCTCAGAAGAATCAACCACAAAATAGTCTTCTCAGATGACCTTGACTAATATACTCAGCATCT
TTATCACTCTTTCCTTGGCACCTAAAAGATAATTCTCCTCTGACGCAGGTTGGAAATATTTTTTTCTATCACAGAAGTCATTTGCAAAGAATTTTGACTACTCTGCTTTTAATTTAATACCAGTTTTCAGGAACCCCTGAAGTTTTAAGT
TCATTATTCTTTATAACATTTGAGAGAATCGGATGTAGTGATATGACAGGGCTGGGGCAAGAACAGGGGCACTAGCTGCCTTATTAGCTAATTTAGTGCCCTCCGTGTTCAGCTTAGCCTTTGACCCTTTCCTTTTGATCCACAAAATAC
ATTAAAACTCTGAATTCACATACAATGCTATTTTAAAGTCAATAGATTTTAGCTATAAAGTGCTTGACCAGTAATGTGGTTGTAATTTTGTGTATGTTCCCCCACATCGCCCCCAACTTCGGATGTGGGGTCAGGAGGTTGAGGTTCACT
ATTAACAAATGTCATAAATATCTCATAGAGGTACAGTGCCAATAGATATTCAAATGTTGCATGTTGACCAGAGGGATTTTATATCTGAAGAACATACACTATTAATAAATACCTTAGAGAAAGATTTTGACCTGGCTTTAGATAAAACTG
TGGCAAGAAAAATGTAATGAGCAATATATGGAAATAAACACACCTTTGTTAAAGATACTTTCTAAACTTGTGTTTAATAAACTTTAATAGTCATAGAATTGTAAATCACTATGGTTAACAGAAAGTGAAAATATTTTCATGCAGATGATG
TGAACAGCCATGTGAATAGGTGACTTGGGCACACAGCAGGGTCATATGACTTCAGAAAACTTCGCTTTTCAGTTATTCCATTGTTATAATGTCAACCCTTTAAGACATTGATGTTTAGAGGGCTCACAAATAAAATCTGAATACCTGTAA


>ADAMTS12_C1QTNF3_ENST00000504830_ENST00000382065_33891834_34035863 length=2255nt 
 Breakpoint=463nt
GAGCGGGCGGGCTGCGAGGCCGCGGGGCATGCGGGAGGCGGAGGGGTGGGGACCGGGGTGGGCTGCGCCCTCCCGCTCTGGCCCATTCCACACCCCGCCGAAAGCGGACACTGTCAGCTGAATCACTCCCCTTTTAGGAGGAGGGAGGGG
AAAAAGGTGTCTAGCTCCTTTCTGCTTAAAAAAGCACAGGGAGATCGCGGGCAGCTTTGCAGTCGCTGCCTTCTCGCGCCTGACCATGCACCCCTGCATCTTCCTGCTGGGCCACAGGCGAGCGCTTTATTTCTGGAGCTGAGGGCTAAA
ACTTTTTTGACTTTTCTTCTCCTCAACATCTGAATCATGCCATGTGCCCAGAGGAGCTGGCTTGCAAACCTTTCCGTGGTGGCTCAGCTCCTTAACTTTGGGGCGCTTTGCTATGGGAGACAGCCTCAGCCAGGCCCGGTTCGCTTCCCG
GACAGGAGGCAAGTCTCCACAAACCGGAGGACTACCCCCAGACTGCAGTAAGTGTTGTCATGGAGACTACAGCTTTCGAGGCTACCAAGGCCCCCCTGGGCCACCGGGCCCTCCTGGCATTCCAGGAAACCATGGAAACAATGGCAACAA
TGGAGCCACTGGTCATGAAGGAGCCAAAGGTGAGAAGGGCGACAAAGGTGACCTGGGGCCTCGAGGGGAGCGGGGGCAGCATGGCCCCAAAGGAGAGAAGGGCTACCCGGGGATTCCACCAGAACTTCAGATTGCATTCATGGCTTCTCT
GGCAACCCACTTCAGCAATCAGAACAGTGGGATTATCTTCAGCAGTGTTGAGACCAACATTGGAAACTTCTTTGATGTCATGACTGGTAGATTTGGGGCCCCAGTATCAGGTGTGTATTTCTTCACCTTCAGCATGATGAAGCATGAGGA
TGTTGAGGAAGTGTATGTGTACCTTATGCACAATGGCAACACAGTCTTCAGCATGTACAGCTATGAAATGAAGGGCAAATCAGATACATCCAGCAATCATGCTGTGCTGAAGCTAGCCAAAGGGGATGAGGTTTGGCTGCGAATGGGCAA
TGGCGCTCTCCATGGGGACCACCAACGCTTCTCCACCTTTGCAGGATTCCTGCTCTTTGAAACTAAGTAAATATATGACTAGAATAGCTCCACTTTGGGGAAGACTTGTAGCTGAGCTGATTTGTTACGATCTGAGGAACATTAAAGTTG
AGGGTTTTACATTGCTGTATTCAAAAAATTATTGGTTGCAATGTTGTTCACGCTACAGGTACACCAATAATGTTGGACAATTCAGGGGCTCAGAAGAATCAACCACAAAATAGTCTTCTCAGATGACCTTGACTAATATACTCAGCATCT
TTATCACTCTTTCCTTGGCACCTAAAAGATAATTCTCCTCTGACGCAGGTTGGAAATATTTTTTTCTATCACAGAAGTCATTTGCAAAGAATTTTGACTACTCTGCTTTTAATTTAATACCAGTTTTCAGGAACCCCTGAAGTTTTAAGT
TCATTATTCTTTATAACATTTGAGAGAATCGGATGTAGTGATATGACAGGGCTGGGGCAAGAACAGGGGCACTAGCTGCCTTATTAGCTAATTTAGTGCCCTCCGTGTTCAGCTTAGCCTTTGACCCTTTCCTTTTGATCCACAAAATAC
ATTAAAACTCTGAATTCACATACAATGCTATTTTAAAGTCAATAGATTTTAGCTATAAAGTGCTTGACCAGTAATGTGGTTGTAATTTTGTGTATGTTCCCCCACATCGCCCCCAACTTCGGATGTGGGGTCAGGAGGTTGAGGTTCACT
ATTAACAAATGTCATAAATATCTCATAGAGGTACAGTGCCAATAGATATTCAAATGTTGCATGTTGACCAGAGGGATTTTATATCTGAAGAACATACACTATTAATAAATACCTTAGAGAAAGATTTTGACCTGGCTTTAGATAAAACTG
TGGCAAGAAAAATGTAATGAGCAATATATGGAAATAAACACACCTTTGTTAAAGATACTTTCTAAACTTGTGTTTAATAAACTTTAATAGTCATAGAATTGTAAATCACTATGGTTAACAGAAAGTGAAAATATTTTCATGCAGATGATG
TGAACAGCCATGTGAATAGGTGACTTGGGCACACAGCAGGGTCATATGACTTCAGAAAACTTCGCTTTTCAGTTATTCCATTGTTATAATGTCAACCCTTTAAGACATTGATGTTTAGAGGGCTCACAAATAAAATCTGAATACCTGTAA
GGAAA

>ADAMTS12_C1QTNF3_ENST00000515401_ENST00000231338_33891834_34035863 length=2077nt 
 Breakpoint=290nt
GCTTAAAAAAGCACAGGGAGATCGCGGGCAGCTTTGCAGTCGCTGCCTTCTCGCGCCTGACCATGCACCCCTGCATCTTCCTGCTGGGCCACAGGCGAGCGCTTTATTTCTGGAGCTGAGGGCTAAAACTTTTTTGACTTTTCTTCTCCT
CAACATCTGAATCATGCCATGTGCCCAGAGGAGCTGGCTTGCAAACCTTTCCGTGGTGGCTCAGCTCCTTAACTTTGGGGCGCTTTGCTATGGGAGACAGCCTCAGCCAGGCCCGGTTCGCTTCCCGGACAGGAGGCAAGTCTCCACAAA
CCGGAGGACTACCCCCAGACTGCAGTAAGTGTTGTCATGGAGACTACAGCTTTCGAGGCTACCAAGGCCCCCCTGGGCCACCGGGCCCTCCTGGCATTCCAGGAAACCATGGAAACAATGGCAACAATGGAGCCACTGGTCATGAAGGAG
CCAAAGGTGAGAAGGGCGACAAAGGTGACCTGGGGCCTCGAGGGGAGCGGGGGCAGCATGGCCCCAAAGGAGAGAAGGGCTACCCGGGGATTCCACCAGAACTTCAGATTGCATTCATGGCTTCTCTGGCAACCCACTTCAGCAATCAGA
ACAGTGGGATTATCTTCAGCAGTGTTGAGACCAACATTGGAAACTTCTTTGATGTCATGACTGGTAGATTTGGGGCCCCAGTATCAGGTGTGTATTTCTTCACCTTCAGCATGATGAAGCATGAGGATGTTGAGGAAGTGTATGTGTACC
TTATGCACAATGGCAACACAGTCTTCAGCATGTACAGCTATGAAATGAAGGGCAAATCAGATACATCCAGCAATCATGCTGTGCTGAAGCTAGCCAAAGGGGATGAGGTTTGGCTGCGAATGGGCAATGGCGCTCTCCATGGGGACCACC
AACGCTTCTCCACCTTTGCAGGATTCCTGCTCTTTGAAACTAAGTAAATATATGACTAGAATAGCTCCACTTTGGGGAAGACTTGTAGCTGAGCTGATTTGTTACGATCTGAGGAACATTAAAGTTGAGGGTTTTACATTGCTGTATTCA
AAAAATTATTGGTTGCAATGTTGTTCACGCTACAGGTACACCAATAATGTTGGACAATTCAGGGGCTCAGAAGAATCAACCACAAAATAGTCTTCTCAGATGACCTTGACTAATATACTCAGCATCTTTATCACTCTTTCCTTGGCACCT
AAAAGATAATTCTCCTCTGACGCAGGTTGGAAATATTTTTTTCTATCACAGAAGTCATTTGCAAAGAATTTTGACTACTCTGCTTTTAATTTAATACCAGTTTTCAGGAACCCCTGAAGTTTTAAGTTCATTATTCTTTATAACATTTGA
GAGAATCGGATGTAGTGATATGACAGGGCTGGGGCAAGAACAGGGGCACTAGCTGCCTTATTAGCTAATTTAGTGCCCTCCGTGTTCAGCTTAGCCTTTGACCCTTTCCTTTTGATCCACAAAATACATTAAAACTCTGAATTCACATAC
AATGCTATTTTAAAGTCAATAGATTTTAGCTATAAAGTGCTTGACCAGTAATGTGGTTGTAATTTTGTGTATGTTCCCCCACATCGCCCCCAACTTCGGATGTGGGGTCAGGAGGTTGAGGTTCACTATTAACAAATGTCATAAATATCT
CATAGAGGTACAGTGCCAATAGATATTCAAATGTTGCATGTTGACCAGAGGGATTTTATATCTGAAGAACATACACTATTAATAAATACCTTAGAGAAAGATTTTGACCTGGCTTTAGATAAAACTGTGGCAAGAAAAATGTAATGAGCA
ATATATGGAAATAAACACACCTTTGTTAAAGATACTTTCTAAACTTGTGTTTAATAAACTTTAATAGTCATAGAATTGTAAATCACTATGGTTAACAGAAAGTGAAAATATTTTCATGCAGATGATGTGAACAGCCATGTGAATAGGTGA
CTTGGGCACACAGCAGGGTCATATGACTTCAGAAAACTTCGCTTTTCAGTTATTCCATTGTTATAATGTCAACCCTTTAAGACATTGATGTTTAGAGGGCTCACAAATAAAATCTGAATACCTGTAA

>ADAMTS12_C1QTNF3_ENST00000515401_ENST00000382065_33891834_34035863 length=2082nt 
 Breakpoint=290nt
GCTTAAAAAAGCACAGGGAGATCGCGGGCAGCTTTGCAGTCGCTGCCTTCTCGCGCCTGACCATGCACCCCTGCATCTTCCTGCTGGGCCACAGGCGAGCGCTTTATTTCTGGAGCTGAGGGCTAAAACTTTTTTGACTTTTCTTCTCCT
CAACATCTGAATCATGCCATGTGCCCAGAGGAGCTGGCTTGCAAACCTTTCCGTGGTGGCTCAGCTCCTTAACTTTGGGGCGCTTTGCTATGGGAGACAGCCTCAGCCAGGCCCGGTTCGCTTCCCGGACAGGAGGCAAGTCTCCACAAA
CCGGAGGACTACCCCCAGACTGCAGTAAGTGTTGTCATGGAGACTACAGCTTTCGAGGCTACCAAGGCCCCCCTGGGCCACCGGGCCCTCCTGGCATTCCAGGAAACCATGGAAACAATGGCAACAATGGAGCCACTGGTCATGAAGGAG
CCAAAGGTGAGAAGGGCGACAAAGGTGACCTGGGGCCTCGAGGGGAGCGGGGGCAGCATGGCCCCAAAGGAGAGAAGGGCTACCCGGGGATTCCACCAGAACTTCAGATTGCATTCATGGCTTCTCTGGCAACCCACTTCAGCAATCAGA
ACAGTGGGATTATCTTCAGCAGTGTTGAGACCAACATTGGAAACTTCTTTGATGTCATGACTGGTAGATTTGGGGCCCCAGTATCAGGTGTGTATTTCTTCACCTTCAGCATGATGAAGCATGAGGATGTTGAGGAAGTGTATGTGTACC
TTATGCACAATGGCAACACAGTCTTCAGCATGTACAGCTATGAAATGAAGGGCAAATCAGATACATCCAGCAATCATGCTGTGCTGAAGCTAGCCAAAGGGGATGAGGTTTGGCTGCGAATGGGCAATGGCGCTCTCCATGGGGACCACC
AACGCTTCTCCACCTTTGCAGGATTCCTGCTCTTTGAAACTAAGTAAATATATGACTAGAATAGCTCCACTTTGGGGAAGACTTGTAGCTGAGCTGATTTGTTACGATCTGAGGAACATTAAAGTTGAGGGTTTTACATTGCTGTATTCA
AAAAATTATTGGTTGCAATGTTGTTCACGCTACAGGTACACCAATAATGTTGGACAATTCAGGGGCTCAGAAGAATCAACCACAAAATAGTCTTCTCAGATGACCTTGACTAATATACTCAGCATCTTTATCACTCTTTCCTTGGCACCT
AAAAGATAATTCTCCTCTGACGCAGGTTGGAAATATTTTTTTCTATCACAGAAGTCATTTGCAAAGAATTTTGACTACTCTGCTTTTAATTTAATACCAGTTTTCAGGAACCCCTGAAGTTTTAAGTTCATTATTCTTTATAACATTTGA
GAGAATCGGATGTAGTGATATGACAGGGCTGGGGCAAGAACAGGGGCACTAGCTGCCTTATTAGCTAATTTAGTGCCCTCCGTGTTCAGCTTAGCCTTTGACCCTTTCCTTTTGATCCACAAAATACATTAAAACTCTGAATTCACATAC
AATGCTATTTTAAAGTCAATAGATTTTAGCTATAAAGTGCTTGACCAGTAATGTGGTTGTAATTTTGTGTATGTTCCCCCACATCGCCCCCAACTTCGGATGTGGGGTCAGGAGGTTGAGGTTCACTATTAACAAATGTCATAAATATCT
CATAGAGGTACAGTGCCAATAGATATTCAAATGTTGCATGTTGACCAGAGGGATTTTATATCTGAAGAACATACACTATTAATAAATACCTTAGAGAAAGATTTTGACCTGGCTTTAGATAAAACTGTGGCAAGAAAAATGTAATGAGCA
ATATATGGAAATAAACACACCTTTGTTAAAGATACTTTCTAAACTTGTGTTTAATAAACTTTAATAGTCATAGAATTGTAAATCACTATGGTTAACAGAAAGTGAAAATATTTTCATGCAGATGATGTGAACAGCCATGTGAATAGGTGA
CTTGGGCACACAGCAGGGTCATATGACTTCAGAAAACTTCGCTTTTCAGTTATTCCATTGTTATAATGTCAACCCTTTAAGACATTGATGTTTAGAGGGCTCACAAATAAAATCTGAATACCTGTAAGGAAA

N-Truncated Transcript (5UTR-3CDS) Sequences

C-Truncated Transcript (5CDS-3UTR) Sequences

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Fusion Protein Sequence for ADAMTS12_C1QTNF3

In-frame Fusion Protein Sequences.

>ADAMTS12_C1QTNF3_ENST00000352040_ENST00000231338_33891834_34035863 length=252nt
MQTFPWWLSSLTLGRFAMGDSLSQARFASRTGGKSPQTGGLPPDCSKCCHGDYSFRGYQGPPGPPGPPGIPGNHGNNGNNGATGHEGAKGEKGDKGDLGPRGERGQHGPKGEKGYPGIPPELQIAFMASLATHFSNQNSGIIFSSVETNI
GNFFDVMTGRFGAPVSGVYFFTFSMMKHEDVEEVYVYLMHNGNTVFSMYSYEMKGKSDTSSNHAVLKLAKGDEVWLRMGNGALHGDHQRFSTFAGFLLFETK

>ADAMTS12_C1QTNF3_ENST00000352040_ENST00000382065_33891834_34035863 length=252nt
MQTFPWWLSSLTLGRFAMGDSLSQARFASRTGGKSPQTGGLPPDCSKCCHGDYSFRGYQGPPGPPGPPGIPGNHGNNGNNGATGHEGAKGEKGDKGDLGPRGERGQHGPKGEKGYPGIPPELQIAFMASLATHFSNQNSGIIFSSVETNI
GNFFDVMTGRFGAPVSGVYFFTFSMMKHEDVEEVYVYLMHNGNTVFSMYSYEMKGKSDTSSNHAVLKLAKGDEVWLRMGNGALHGDHQRFSTFAGFLLFETK

>ADAMTS12_C1QTNF3_ENST00000504830_ENST00000231338_33891834_34035863 length=252nt
MQTFPWWLSSLTLGRFAMGDSLSQARFASRTGGKSPQTGGLPPDCSKCCHGDYSFRGYQGPPGPPGPPGIPGNHGNNGNNGATGHEGAKGEKGDKGDLGPRGERGQHGPKGEKGYPGIPPELQIAFMASLATHFSNQNSGIIFSSVETNI
GNFFDVMTGRFGAPVSGVYFFTFSMMKHEDVEEVYVYLMHNGNTVFSMYSYEMKGKSDTSSNHAVLKLAKGDEVWLRMGNGALHGDHQRFSTFAGFLLFETK

>ADAMTS12_C1QTNF3_ENST00000504830_ENST00000382065_33891834_34035863 length=1131nt
MPCAQRSWLANLSVVAQLLNFGALCYGRQPQPGPVRFPDRRQEHFIKGLPEYHVVGPVRVDASGHFLSYGLHYPITSSRRKRDLDGSEDWVYYRISHEEKDLFFNLTVNQGFLSNSYIMEKRYGNLSHVKMMASSAPLCHLSGTVLQQGT
RVGTAALSACHGLTNEWNKNDDRLLQAVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECLRVMITHGVDVTAQDTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSSGKTALHYAAAQGCLQAVQILCEHKSPINLKD
LDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTALMLACEIGSSNAVEALIKKGADLNLVDSLGYNALHYSKLSENAGIQSLLLSKISQDADLKTPTKPKQHDQVSKISSERSGTPKKRKAPPPPISPTQLSDVSSPRSITSTPL
SGKESVFFAEPPFKAEISSIRENKDRLSDSTTGADSLLDISSEADQQDLLSLLQAKVASLTLHNKELQDKLQAKSPKEAEADLSFDSYHSTQTDLGPSLGKPGETSPPDSKSSPSVLIHSLGKSTTDNDVRIQQLQEILQDLQKRLESSE
AERKQLQVELQSRRAELVCLNNTEISENSSDLSQKLKETQSKYEEAMKEVLSVQKQMKLGLVSPESMDNYSHFHELRVTEEEINVLKQDLQNALEESERNKEKVRELEEKLVEREKGTVIKPPVEEYEEMKSSYCSVIENMNKEKAFLFE
KYQEAQEEIMKLKDTLKSQMTQEASDEAEDMKEAMNRMIDELNKQVSELSQLYKEAQAELEDYRKRKSLEDVTAEYIHKAEHEKLMQLTNVSRAKAEDALSEMKSQYSKVLNELTQLKQLVDAQKENSVSITEHLQVITTLRTAAKEMEE
KISNLKEHLASKEVEVAKLEKQLLEEKAAMTDAMVPRSSYEKLQSSLESEVSVLASKLKESVKEKEKVHSEVVQIRSEVSQVKREKENIQTLLKSKEQEVNELLQKFQQAQEELAEMKRYAESSSKLEEDKDKKINEMSKEVTKLKEALN
SLSQLSYSTSSSKRQSQQLEALQQQVKQLQNQLAECKKQHQEVISVYRMHLLYAVQGQMDEDVQKVLKQILTMCKNQSQKK

>ADAMTS12_C1QTNF3_ENST00000515401_ENST00000231338_33891834_34035863 length=252nt
MQTFPWWLSSLTLGRFAMGDSLSQARFASRTGGKSPQTGGLPPDCSKCCHGDYSFRGYQGPPGPPGPPGIPGNHGNNGNNGATGHEGAKGEKGDKGDLGPRGERGQHGPKGEKGYPGIPPELQIAFMASLATHFSNQNSGIIFSSVETNI
GNFFDVMTGRFGAPVSGVYFFTFSMMKHEDVEEVYVYLMHNGNTVFSMYSYEMKGKSDTSSNHAVLKLAKGDEVWLRMGNGALHGDHQRFSTFAGFLLFETK

>ADAMTS12_C1QTNF3_ENST00000515401_ENST00000382065_33891834_34035863 length=252nt
MQTFPWWLSSLTLGRFAMGDSLSQARFASRTGGKSPQTGGLPPDCSKCCHGDYSFRGYQGPPGPPGPPGIPGNHGNNGNNGATGHEGAKGEKGDKGDLGPRGERGQHGPKGEKGYPGIPPELQIAFMASLATHFSNQNSGIIFSSVETNI
GNFFDVMTGRFGAPVSGVYFFTFSMMKHEDVEEVYVYLMHNGNTVFSMYSYEMKGKSDTSSNHAVLKLAKGDEVWLRMGNGALHGDHQRFSTFAGFLLFETK

N-Truncated Protein (5UTR-3CDS) Sequences

C-Truncated Protein (5CDS-3UTR) Sequences

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Personalized Fusion Protein Sequence for ADAMTS12_C1QTNF3

TCGA Kinase/DNA-binding Domain Mutated Fusion Protein Sequences

Num

Gene Group

Domain Loci

Fusion Protein ID

Fusion Gene Name

Partner

Mutated Residue in WT Protein

Seq. Length

Mutated Residue in Fusion Protein

CCLE Kinase/DNA-binding Domain Mutated Fusion Protein Sequences

Num

Gene Group

Domain Loci

Fusion Protein ID

Fusion Gene Name

Partner

Mutated Residue in WT Protein

Seq. Length

Mutated Residue in Fusion Protein

TCGA All Mutated Fusion Protein Sequences

Fusion Protein ID

Sample ID

Mutated Partner

AAchange in WT

Seq. Length

AAchange in Fusion

CCLE All Mutated Fusion Protein Sequences

Fusion Protein ID

Sample ID

Mutated Partner

AAchange in WT

Seq. Length

AAchange in Fusion

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Fusion Gene Exprssed Samples for ADAMTS12_C1QTNF3

RNA-seq based fusion gene expressed samples.

Source	Study	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB		BRCA	TCGA-AN-A0AR-01A	ADAMTS12	chr5	33891834	-	C1QTNF3	chr5	34035863	-
TCGAfusionPortal		BRCA	TCGA-AN-A0AR-01A	ADAMTS12	chr5	33891835	-	C1QTNF3	chr5	34035863	-

DNA-seq based fusion gene expressed samples.

Source

Study

Disease

Sample

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

SV type

dbVar

nstd151

Unknown_Cell

ADAMTS12

chr5

33561129

C1QTNF3

chr5

34043235

DEL

dbVar

nstd166

Unknown_Cell

ADAMTS12

chr5

33824748

C1QTNF3

chr5

34032480

DUP

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Related Drugs for ADAMTS12_C1QTNF3

PubMed Abstract Search With ['A-B' AND 'drug'], ['A::B' AND 'drug']
* For more details on the Studied, Reported, Approved Drugs targeting this fusion gene, Go to FusionPub.

PMID

Fusion Gene Name

Drug

Study Title

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status