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	Fusion Gene Summary
	Fusion Gene Breakpoints
	Tumorigenic MoA (Mechanism of Action) Scenarios of Fusion Geness
	Fusion Genomic Features
	Fusion Gene ORF Annotations
	Fusion Protein Retained/Non-Retained Functional Features
	Fusion Transcript Sequences
	Fusion Protein Sequences
	Personalized Fusion Protein Sequences
	Fusion Gene Expressed Samples
	Related Drugs

Fusion gene:ITCH_MANBAL (FusionGDB2 ID:HG83737TG63905)

Fusion Gene Summary for ITCH_MANBAL

Fusion gene summary

Fusion gene information	Fusion gene name: ITCH_MANBAL
	Fusion gene ID: hg83737tg63905
		Hgene	Tgene
	Gene symbol	ITCH	MANBAL
	Gene ID	83737	63905
	Gene name	itchy E3 ubiquitin protein ligase	mannosidase beta like
	Synonyms	ADMFD\|AIF4\|AIP4\|NAPP1	-
	Cytomap	20q11.22	20q11.23
	Type of gene	protein-coding	protein-coding
	Description	E3 ubiquitin-protein ligase Itchy homologHECT-type E3 ubiquitin transferase Itchy homologNFE2-associated polypeptide 1atrophin-1 interacting protein 4itchy E3 ubiquitin protein ligase homolog	protein MANBALmannosidase beta A likemannosidase, beta A, lysosomal-like
	Modification date	20240403	20240305
	UniProtAcc	Q96J02	Q9NQG1
	Ensembl transtripts involved in fusion gene	ENST00000262650, ENST00000374864, ENST00000483727, ENST00000535650,
Fusion gene scores	* DoF score	* DoF score (Degree of Frequency) = # partners X # break points X # disease types 40 X 36 X 32=46080	* DoF score (Degree of Frequency) = # partners X # break points X # disease types 2 X 11 X 5=110
	# samples	1961	8
	** MAII score	** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score10) log2(1961/4608010)=-1.23255118125016 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score10) log2(8/11010)=-0.459431618637297 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: ITCH [Title/Abstract] AND MANBAL [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	ITCH(32996598)-MANBAL(35944710), # samples:1

Fusion gene breakpoints across ITCH (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across MANBAL (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Breakpoints for ITCH_MANBAL

RNA-seq based exon junction arranged fusion gene breakpoints from 8 resources (TCGA, CCLE, cBioPortal, GenBank, ChimerDB, ChimerKB, ChildHoodFusions, and GTEx). For the expressed sample information, go to Fusion Gene Sample section.

Hgene	Hchr	Hbp	Tgene	Tchr	Tbp
ITCH	chr20	32996598	MANBAL	chr20	32996598
ITCH	chr20	32996598	MANBAL	chr20	35944711

DNA-seq based exon junction arranged fusion gene breakpoints from dbVar. For the expressed sample information, go to Fusion Gene Sample section.

Hgene

Hchr

Hbp

Tgene

Tchr

Tbp

SV type

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Tumorigenic MoA (Mechanism of Action) Scenarios of Fusion Genes for ITCH_MANBAL

To generate these tumorigenic scenario annotations, we implemented a deduction-first, retrieval-later computational framework. The pipeline first applies rule-guided reasoning across ten core mechanistic categories (M1–M10) derived from fusion gene biology to infer candidate mechanisms, tumorigenic scenarios, targeting points, and targeting backgrounds. To ensure empirical accountability, a governed Python workflow retrieves literature candidates via NCBI E-utilities and Europe PMC using tiered searches. Using JSON Schema-constrained LLM evidence judges (GPT-5.6 Luna and Terra), retrieved articles are evaluated for specificity and confidence without de novo PMID generation. This produces two distinct versions: a strict version restricted to high- or medium-confidence fusion-specific evidence, and an extended version incorporating broader gene-, pathway-, and contextual evidence.

* We have 10 tumorigenic mechanism categories of fusion genes as shown below.

Constitutively Active Kinases, Catalytic Domain Dysregulation, & Transmembrane Ligand Fusions	Aberrant Chimeric Transcription Factor / Fusion Transcription Factor Activity	Epigenetic Reprogramming / Histone Modifier Dysregulation	Chromatin Remodeling Dysregulation	Condensate-Driven Transcriptional Rewiring / LLP	Promoter / Enhancer Hijacking	Dominant-Negative Antagonism	Cell Cycle / Checkpoint Bypass / RNA Processing Dysregulation	Subcellular Mislocalization / Spatial Dysregulation	Nuclear Body / Sub-organellar Architecture Disruption & Differentiation Blockade

* Strict version: Restricted to high- or medium-confidence fusion-specific evidence.

Fusion Gene Name	Mechanism Category	Mechanism PubMed	Tumorigenic Scenarios	Tumorigenic Scenario PubMed	Targeting Points	Targeting PubMed	Mechanism Background	Mechanism Background PubMed
ITCH-MANBAL	Promoter / Enhancer Hijacking M6		ITCH HECT E3 ligase promoter drives mannosidase beta-like (MANBAL) expression, modifying Golgi glycosylation pathways.		Glycosylation pathway inhibitors; proteasome inhibitors		Carcinomas

* Extended version: Includes all strict-level fusion evidence plus broader gene-, pathway-, and low-confidence contextual evidence.

Fusion Gene Name	Mechanism Category	Mechanism PubMed	Tumorigenic Scenarios	Tumorigenic Scenario PubMed	Targeting Points	Targeting PubMed	Mechanism Background	Mechanism Background PubMed
ITCH-MANBAL	Promoter / Enhancer Hijacking M6		ITCH HECT E3 ligase promoter drives mannosidase beta-like (MANBAL) expression, modifying Golgi glycosylation pathways.		Glycosylation pathway inhibitors; proteasome inhibitors		Carcinomas	Evidence level: Indirect gene evidence; Confidence: Medium; PMID: 34709988; Title: Screening and cellular validation of prognostic genes regulated by super enhancers in oral squamous cell carcinoma.; PMID: 31517839; Title: Using weighted gene co-expression network analysis to identify key modules and hub genes in tongue squamous cell carcinoma.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
ITCH Q96J02	MANBAL Q9NQG1

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	ITCH	GO:0006511	ubiquitin-dependent protein catabolic process	15678106
Hgene	ITCH	GO:0006513	protein monoubiquitination	34927784
Hgene	ITCH	GO:0016567	protein ubiquitination	17592138\|25631046
Hgene	ITCH	GO:0035519	protein K29-linked ubiquitination	17028573\|18628966
Hgene	ITCH	GO:0039532	negative regulation of cytoplasmic pattern recognition receptor signaling pathway	27736772
Hgene	ITCH	GO:0070534	protein K63-linked ubiquitination	18718448\|19592251
Hgene	ITCH	GO:0070936	protein K48-linked ubiquitination	19881509\|27736772\|30328013

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Fusion Genomic Features for ITCH_MANBAL

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence) of In-frame fusion genes. FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
ITCH	chr20	32996598	+	MANBAL	chr20	35944710	+	1.60e-07	1.00e+00

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence) of 5UTR-3CSD fusion genes (N-truncated cases).

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence) of 5CDS-3UTR fusion genes (C-truncated cases).

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of six genomic regulatory feature tracks across a ±5 kb window centered on the fusion breakpoints. We input the breakpoint sequences into AlphaGenome and obtained predicted genome tracks at single-base-pair resolution for each modality by running a single forward pass over the reference sequence. Specifically, for each breakpoint, AlphaGenome processed and returned predicted track data across diverse modalities, which were then averaged across all tracks within each output type and visualized across the ±5 kb window. The left panel shows the 5'-gene breakpoint ±5 kb area, and the right panel shows the 3'-gene breakpoint area, with tracks grouped by category: chromatin accessibility (DNase-seq, ATAC-seq), active transcription (RNA-seq, CAGE), and chromatin binding (ChIP-Histone, ChIP-TF).

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Fusion Gene ORF Annotations for ITCH_MANBAL

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-3UTR	ENST00000262650	ENST00000373605	ITCH	chr20	32996598	+	MANBAL	chr20	35944710	+
5CDS-3UTR	ENST00000262650	ENST00000397150	ITCH	chr20	32996598	+	MANBAL	chr20	35944710	+
5CDS-3UTR	ENST00000262650	ENST00000397151	ITCH	chr20	32996598	+	MANBAL	chr20	35944710	+
5CDS-3UTR	ENST00000262650	ENST00000397152	ITCH	chr20	32996598	+	MANBAL	chr20	35944710	+
5CDS-3UTR	ENST00000374864	ENST00000373605	ITCH	chr20	32996598	+	MANBAL	chr20	35944710	+
5CDS-3UTR	ENST00000374864	ENST00000397150	ITCH	chr20	32996598	+	MANBAL	chr20	35944710	+
5CDS-3UTR	ENST00000374864	ENST00000397151	ITCH	chr20	32996598	+	MANBAL	chr20	35944710	+
5CDS-3UTR	ENST00000374864	ENST00000397152	ITCH	chr20	32996598	+	MANBAL	chr20	35944710	+
Frame-shift	ENST00000262650	ENST00000373606	ITCH	chr20	32996598	+	MANBAL	chr20	35944710	+
Frame-shift	ENST00000374864	ENST00000373606	ITCH	chr20	32996598	+	MANBAL	chr20	35944710	+
In-frame	ENST00000262650	ENST00000397156	ITCH	chr20	32996598	+	MANBAL	chr20	35944710	+
In-frame	ENST00000374864	ENST00000397156	ITCH	chr20	32996598	+	MANBAL	chr20	35944710	+

ORFfinder Result Based On The Fusion Transcript Sequences of the In-frame Fusion Genes.

Henst	Tenst	Hgene	Hchr	Hbp	Tgene	Tchr	Tbp	Seq length (transcript)	Seq length (peptide)
ENST00000262650	ENST00000397156	ITCH	chr20	32996598	MANBAL	chr20	35944710	348	118
ENST00000374864	ENST00000397156	ITCH	chr20	32996598	MANBAL	chr20	35944710	425	214

ORFfinder Result Based On The Fusion Transcript Sequences of the 5UTR-3CDS Fusion Genes for N-Truncated Protein Search.

Henst

Tenst

Hgene

Hchr

Hbp

Tgene

Tchr

Tbp

Seq length
(transcript)

Seq length
(peptide)

ORFfinder Result Based On The Fusion Transcript Sequences of the 5CDS-3UTR Fusion Genes for C-Truncated Protein Search.

Henst

Tenst

Hgene

Hchr

Hbp

Tgene

Tchr

Tbp

Seq length
(transcript)

Seq length
(peptide)

DeepORF Prediction of The Coding Potential Based on The Fusion Transcript Sequence of In-frame Fusion Genes. DeepORF is a Coding Potential Classifier Based on Convolutional Neural Network by Comparing the Real Ribo-seq Data. If the No-coding Score < 0.5 and Coding Score > 0.5, Then The In-frame Fusion Transcript is Predicted as Being Likely Translated.

Henst	Tenst	Hgene	Hchr	Hbp	Tgene	Tchr	Tbp	No-coding score	Coding score
ENST00000262650	ENST00000397156	ITCH	chr20	32996598	MANBAL	chr20	35944710	9.49e-01	5.10e-02
ENST00000374864	ENST00000397156	ITCH	chr20	32996598	MANBAL	chr20	35944710	8.98e-01	1.02e-01

DeepORF Prediction of The Coding Potential Based on The Fusion Transcript Sequence of 5UTR-3CDS Fusion Genes (Potential N-Truncated Proteins).

Henst

Tenst

Hgene

Hchr

Hbp

Tgene

Tchr

Tbp

No-coding score

Coding score

DeepORF Prediction of The Coding Potential Based on The Fusion Transcript Sequence of 5CDS-3UTR Fusion Genes (Potential C-Truncated Proteins).

Henst	Tenst	Hgene	Hchr	Hbp	Tgene	Tchr	Tbp	No-coding score	Coding score
ENST00000262650	ENST00000373605	ITCH	chr20	32996598	MANBAL	chr20	35944710	0.00e+00	9.47e-01
ENST00000262650	ENST00000397150	ITCH	chr20	32996598	MANBAL	chr20	35944710	0.00e+00	5.61e-01
ENST00000262650	ENST00000397151	ITCH	chr20	32996598	MANBAL	chr20	35944710	0.00e+00	9.47e-01
ENST00000262650	ENST00000397152	ITCH	chr20	32996598	MANBAL	chr20	35944710	0.00e+00	9.47e-01
ENST00000374864	ENST00000373605	ITCH	chr20	32996598	MANBAL	chr20	35944710	0.00e+00	8.95e-01
ENST00000374864	ENST00000397150	ITCH	chr20	32996598	MANBAL	chr20	35944710	0.00e+00	2.07e-01
ENST00000374864	ENST00000397151	ITCH	chr20	32996598	MANBAL	chr20	35944710	0.00e+00	8.95e-01
ENST00000374864	ENST00000397152	ITCH	chr20	32996598	MANBAL	chr20	35944710	0.00e+00	8.95e-01

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Fusion Protein Retained/Non-Retained Functional Features for ITCH_MANBAL

Protein Level Annotation from FGviewer
* Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at download page. Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features (visualization across fusion protein length).

ITCH_MANBAL_chr20-32996598_chr20-35944710.png

- In-frame and retained protein feature among the 13 regional features (texts).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

MANBAL

chr20:32996598

chr20:35944710

ENST00000397156

Q9NQG1

48_64

50.0

86.0

Compositional bias

Basic and acidic residues

Tgene

MANBAL

chr20:32996598

chr20:35944710

ENST00000397156

Q9NQG1

75_85

50.0

86.0

Compositional bias

Basic residues

Tgene

MANBAL

chr20:32996598

chr20:35944710

ENST00000397156

Q9NQG1

48_85

50.0

86.0

Region

Disordered

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

ITCH

chr20:32996598

chr20:35944710

ENST00000262650

Q96J02

206_215

70.66666666666667

904.0

Compositional bias

Basic and acidic residues

Hgene

ITCH

chr20:32996598

chr20:35944710

ENST00000262650

Q96J02

236_247

70.66666666666667

904.0

Compositional bias

Low complexity

Hgene

ITCH

chr20:32996598

chr20:35944710

ENST00000262650

Q96J02

251_265

70.66666666666667

904.0

Compositional bias

Pro residues

Hgene

ITCH

chr20:32996598

chr20:35944710

ENST00000262650

Q96J02

270_281

70.66666666666667

904.0

Compositional bias

Polar residues

Hgene

ITCH

chr20:32996598

chr20:35944710

ENST00000262650

Q96J02

282_298

70.66666666666667

904.0

Compositional bias

Low complexity

Hgene

ITCH

chr20:32996598

chr20:35944710

ENST00000262650

Q96J02

1_115

70.66666666666667

904.0

Domain

Hgene

ITCH

chr20:32996598

chr20:35944710

ENST00000262650

Q96J02

326_359

70.66666666666667

904.0

Domain

WW 1

Hgene

ITCH

chr20:32996598

chr20:35944710

ENST00000262650

Q96J02

358_391

70.66666666666667

904.0

Domain

WW 2

Hgene

ITCH

chr20:32996598

chr20:35944710

ENST00000262650

Q96J02

438_471

70.66666666666667

904.0

Domain

WW 3

Hgene

ITCH

chr20:32996598

chr20:35944710

ENST00000262650

Q96J02

478_511

70.66666666666667

904.0

Domain

WW 4

Hgene

ITCH

chr20:32996598

chr20:35944710

ENST00000262650

Q96J02

569_903

70.66666666666667

904.0

Domain

HECT

Hgene

ITCH

chr20:32996598

chr20:35944710

ENST00000262650

Q96J02

197_301

70.66666666666667

904.0

Region

Disordered

Hgene

ITCH

chr20:32996598

chr20:35944710

ENST00000262650

Q96J02

574_583

70.66666666666667

904.0

Region

MAP kinase docking site

Tgene

MANBAL

chr20:32996598

chr20:35944710

ENST00000397156

Q9NQG1

24_44

50.0

86.0

Transmembrane

Helical

- Retained PPIs in in-frame fusion.

Partner

Hgene

Hbp

Tgene

Tbp

ENST

UniProt

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Hgene

Hbp

Tgene

Tbp

ENST

UniProt

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Fusion Transcript Sequence for ITCH_MANBAL

In-frame Fusion Transcript Sequences.

>ITCH_MANBAL_ENST00000262650_ENST00000397156_32996598_35944710 length=1297nt 
 Breakpoint=348nt
GTCTAGGGACTGAGGAGTCGCCGCCGCCCCGAGTCCCGGTACCATGCATTTCACGGTGGCCTTGTGGAGACAACGCCTTAACCCAAGGAAGTGACTCAAACTGTGAGAACTTCAGGTTTTCCAACCTATTGGTGGTATGTCTGACAGTGG
ATCACAACTTGGTTCAATGGGTAGCCTCACCATGAAATCACAGCTTCAGATCACTGTCATCTCAGCAAAACTTAAGGAAAATAAGAAGAATTGGTTTGGACCAAGTCCTTACGTAGAGGTCACAGTAGATGGACAGTCAAAGAAGACAGA
AAAATGCAACAACACAAACAGTCCCAAGTGGAAGCAACCCCTTACAGTGAGGCTGAACCGTCTGAGCCCAGAAGTGCTGAGGTGACGAGGAAGCCCAAGGCTGCTGTTCCTTCTGTGAACAAGAGGCCCAAGAAAGAGACTAAGAAGAAG
CGGTAGAAGAGGAGGCCTGAGGAGCTGGGCGGGCAGGGAGAGGGTCTTGGGGACAGCCCTCCTGGGAATCTACATTGTGTTCCCCCGCATTCCAGGCTCAGGGTCTGAGGAGGCTGTGACGCCCTATGACCGCAGAGATCTAGACAGTCG
TAACAGTCCCCAGGCTCCAGCTGGGCAATCCACCACTTCCTCTTCCTTCTGCTTCTGTGACGGTTTAGAGTCAAGGGGGCTGAAACACACTGTGAGCATAGACTGTATTAGGTTTGTTCAGAAGCCGGGTCAGCTCACAGAGTCACATTT
TCTTGCTTAGTCATGTGTCCCTCCTTGAGTTGCCCCCTCCTTGTGGGTTTACACTACATTTGGGAGTCATTGTCTAATGCTGACAAGCACACCCTCTCCCATTATTTGTGCACTACAGATCTCCTCCTGATCAGTCACCTTTGTTGCTGC
TGTGTAGACAGAGCCAGGCCTCACCTGTTTGTTTAGGCCAAGATGCCATGGACATGCAGCGTTAGTGATCCCACTAGCTGTGACAGCCAGGCCCAGAAAATGCCTGGCGTGAGAGCCAGCAGACAGCCAGGCCAGGGTAGGCAGTGCCTG
CTTCTGCTCCATCAGGTGCAGGGGATTTGGCTGAAGGCGTGCATATTTCCTGGGCACAAACTTCCTGAGCCTCTGAAATGGGAGGCTCGTCAATTTCAGACCAACCTCTTTTCAACCCATCATAGCACGTTCAAGGTGTGCCTTTTACTT
CTACCTGTACATCCCCCATCCCTTCAATTCTTTCATTCCCTGACCAGTGAGAGGGTTCCTGGGGGAAGTATGGTGAATAAACTGACATGCATGCTTC

>ITCH_MANBAL_ENST00000374864_ENST00000397156_32996598_35944710 length=1374nt 
 Breakpoint=425nt
GCGCTCAGGCGCCTGCGCTTTAGCTGCTAACTCGCTCTAGTAGCTGTGGTCGGGGCTCGGGACCGGCTGCCATCTTAGTCTAGGGACTGAGGAGTCGCCGCCGCCCCGAGTCCCGGTACCATGCATTTCACGGTGGCCTTGTGGAGACAA
CGCCTTAACCCAAGGAAGTGACTCAAACTGTGAGAACTTCAGGTTTTCCAACCTATTGGTGGTATGTCTGACAGTGGATCACAACTTGGTTCAATGGGTAGCCTCACCATGAAATCACAGCTTCAGATCACTGTCATCTCAGCAAAACTT
AAGGAAAATAAGAAGAATTGGTTTGGACCAAGTCCTTACGTAGAGGTCACAGTAGATGGACAGTCAAAGAAGACAGAAAAATGCAACAACACAAACAGTCCCAAGTGGAAGCAACCCCTTACAGTGAGGCTGAACCGTCTGAGCCCAGAA
GTGCTGAGGTGACGAGGAAGCCCAAGGCTGCTGTTCCTTCTGTGAACAAGAGGCCCAAGAAAGAGACTAAGAAGAAGCGGTAGAAGAGGAGGCCTGAGGAGCTGGGCGGGCAGGGAGAGGGTCTTGGGGACAGCCCTCCTGGGAATCTAC
ATTGTGTTCCCCCGCATTCCAGGCTCAGGGTCTGAGGAGGCTGTGACGCCCTATGACCGCAGAGATCTAGACAGTCGTAACAGTCCCCAGGCTCCAGCTGGGCAATCCACCACTTCCTCTTCCTTCTGCTTCTGTGACGGTTTAGAGTCA
AGGGGGCTGAAACACACTGTGAGCATAGACTGTATTAGGTTTGTTCAGAAGCCGGGTCAGCTCACAGAGTCACATTTTCTTGCTTAGTCATGTGTCCCTCCTTGAGTTGCCCCCTCCTTGTGGGTTTACACTACATTTGGGAGTCATTGT
CTAATGCTGACAAGCACACCCTCTCCCATTATTTGTGCACTACAGATCTCCTCCTGATCAGTCACCTTTGTTGCTGCTGTGTAGACAGAGCCAGGCCTCACCTGTTTGTTTAGGCCAAGATGCCATGGACATGCAGCGTTAGTGATCCCA
CTAGCTGTGACAGCCAGGCCCAGAAAATGCCTGGCGTGAGAGCCAGCAGACAGCCAGGCCAGGGTAGGCAGTGCCTGCTTCTGCTCCATCAGGTGCAGGGGATTTGGCTGAAGGCGTGCATATTTCCTGGGCACAAACTTCCTGAGCCTC
TGAAATGGGAGGCTCGTCAATTTCAGACCAACCTCTTTTCAACCCATCATAGCACGTTCAAGGTGTGCCTTTTACTTCTACCTGTACATCCCCCATCCCTTCAATTCTTTCATTCCCTGACCAGTGAGAGGGTTCCTGGGGGAAGTATGG
TGAATAAACTGACATGCATGCTTC

N-Truncated Transcript (5UTR-3CDS) Sequences

C-Truncated Transcript (5CDS-3UTR) Sequences

>ITCH_MANBAL_ENST00000262650_ENST00000373605_32996598_35944710 length=1301nt 
 Breakpoint=348nt
GTCTAGGGACTGAGGAGTCGCCGCCGCCCCGAGTCCCGGTACCATGCATTTCACGGTGGCCTTGTGGAGACAACGCCTTAACCCAAGGAAGTGACTCAAACTGTGAGAACTTCAGGTTTTCCAACCTATTGGTGGTATGTCTGACAGTGG
ATCACAACTTGGTTCAATGGGTAGCCTCACCATGAAATCACAGCTTCAGATCACTGTCATCTCAGCAAAACTTAAGGAAAATAAGAAGAATTGGTTTGGACCAAGTCCTTACGTAGAGGTCACAGTAGATGGACAGTCAAAGAAGACAGA
AAAATGCAACAACACAAACAGTCCCAAGTGGAAGCAACCCCTTACAGTGAGGCTGAACCGTCTGAGCCCAGAAGTGCTGAGGTGACGAGGAAGCCCAAGGCTGCTGTTCCTTCTGTGAACAAGAGGCCCAAGAAAGAGACTAAGAAGAAG
CGGTAGAAGAGGAGGCCTGAGGAGCTGGGCGGGCAGGGAGAGGGTCTTGGGGACAGCCCTCCTGGGAATCTACATTGTGTTCCCCCGCATTCCAGGCTCAGGGTCTGAGGAGGCTGTGACGCCCTATGACCGCAGAGATCTAGACAGTCG
TAACAGTCCCCAGGCTCCAGCTGGGCAATCCACCACTTCCTCTTCCTTCTGCTTCTGTGACGGTTTAGAGTCAAGGGGGCTGAAACACACTGTGAGCATAGACTGTATTAGGTTTGTTCAGAAGCCGGGTCAGCTCACAGAGTCACATTT
TCTTGCTTAGTCATGTGTCCCTCCTTGAGTTGCCCCCTCCTTGTGGGTTTACACTACATTTGGGAGTCATTGTCTAATGCTGACAAGCACACCCTCTCCCATTATTTGTGCACTACAGATCTCCTCCTGATCAGTCACCTTTGTTGCTGC
TGTGTAGACAGAGCCAGGCCTCACCTGTTTGTTTAGGCCAAGATGCCATGGACATGCAGCGTTAGTGATCCCACTAGCTGTGACAGCCAGGCCCAGAAAATGCCTGGCGTGAGAGCCAGCAGACAGCCAGGCCAGGGTAGGCAGTGCCTG
CTTCTGCTCCATCAGGTGCAGGGGATTTGGCTGAAGGCGTGCATATTTCCTGGGCACAAACTTCCTGAGCCTCTGAAATGGGAGGCTCGTCAATTTCAGACCAACCTCTTTTCAACCCATCATAGCACGTTCAAGGTGTGCCTTTTACTT
CTACCTGTACATCCCCCATCCCTTCAATTCTTTCATTCCCTGACCAGTGAGAGGGTTCCTGGGGGAAGTATGGTGAATAAACTGACATGCATGCTTCAGAA

>ITCH_MANBAL_ENST00000262650_ENST00000397150_32996598_35944710 length=348nt 
 Breakpoint=348nt
GTCTAGGGACTGAGGAGTCGCCGCCGCCCCGAGTCCCGGTACCATGCATTTCACGGTGGCCTTGTGGAGACAACGCCTTAACCCAAGGAAGTGACTCAAACTGTGAGAACTTCAGGTTTTCCAACCTATTGGTGGTATGTCTGACAGTGG
ATCACAACTTGGTTCAATGGGTAGCCTCACCATGAAATCACAGCTTCAGATCACTGTCATCTCAGCAAAACTTAAGGAAAATAAGAAGAATTGGTTTGGACCAAGTCCTTACGTAGAGGTCACAGTAGATGGACAGTCAAAGAAGACAGA
AAAATGCAACAACACAAACAGTCCCAAGTGGAAGCAACCCCTTACAGT

>ITCH_MANBAL_ENST00000262650_ENST00000397151_32996598_35944710 length=1301nt 
 Breakpoint=348nt
GTCTAGGGACTGAGGAGTCGCCGCCGCCCCGAGTCCCGGTACCATGCATTTCACGGTGGCCTTGTGGAGACAACGCCTTAACCCAAGGAAGTGACTCAAACTGTGAGAACTTCAGGTTTTCCAACCTATTGGTGGTATGTCTGACAGTGG
ATCACAACTTGGTTCAATGGGTAGCCTCACCATGAAATCACAGCTTCAGATCACTGTCATCTCAGCAAAACTTAAGGAAAATAAGAAGAATTGGTTTGGACCAAGTCCTTACGTAGAGGTCACAGTAGATGGACAGTCAAAGAAGACAGA
AAAATGCAACAACACAAACAGTCCCAAGTGGAAGCAACCCCTTACAGTGAGGCTGAACCGTCTGAGCCCAGAAGTGCTGAGGTGACGAGGAAGCCCAAGGCTGCTGTTCCTTCTGTGAACAAGAGGCCCAAGAAAGAGACTAAGAAGAAG
CGGTAGAAGAGGAGGCCTGAGGAGCTGGGCGGGCAGGGAGAGGGTCTTGGGGACAGCCCTCCTGGGAATCTACATTGTGTTCCCCCGCATTCCAGGCTCAGGGTCTGAGGAGGCTGTGACGCCCTATGACCGCAGAGATCTAGACAGTCG
TAACAGTCCCCAGGCTCCAGCTGGGCAATCCACCACTTCCTCTTCCTTCTGCTTCTGTGACGGTTTAGAGTCAAGGGGGCTGAAACACACTGTGAGCATAGACTGTATTAGGTTTGTTCAGAAGCCGGGTCAGCTCACAGAGTCACATTT
TCTTGCTTAGTCATGTGTCCCTCCTTGAGTTGCCCCCTCCTTGTGGGTTTACACTACATTTGGGAGTCATTGTCTAATGCTGACAAGCACACCCTCTCCCATTATTTGTGCACTACAGATCTCCTCCTGATCAGTCACCTTTGTTGCTGC
TGTGTAGACAGAGCCAGGCCTCACCTGTTTGTTTAGGCCAAGATGCCATGGACATGCAGCGTTAGTGATCCCACTAGCTGTGACAGCCAGGCCCAGAAAATGCCTGGCGTGAGAGCCAGCAGACAGCCAGGCCAGGGTAGGCAGTGCCTG
CTTCTGCTCCATCAGGTGCAGGGGATTTGGCTGAAGGCGTGCATATTTCCTGGGCACAAACTTCCTGAGCCTCTGAAATGGGAGGCTCGTCAATTTCAGACCAACCTCTTTTCAACCCATCATAGCACGTTCAAGGTGTGCCTTTTACTT
CTACCTGTACATCCCCCATCCCTTCAATTCTTTCATTCCCTGACCAGTGAGAGGGTTCCTGGGGGAAGTATGGTGAATAAACTGACATGCATGCTTCAGAA

>ITCH_MANBAL_ENST00000262650_ENST00000397152_32996598_35944710 length=1301nt 
 Breakpoint=348nt
GTCTAGGGACTGAGGAGTCGCCGCCGCCCCGAGTCCCGGTACCATGCATTTCACGGTGGCCTTGTGGAGACAACGCCTTAACCCAAGGAAGTGACTCAAACTGTGAGAACTTCAGGTTTTCCAACCTATTGGTGGTATGTCTGACAGTGG
ATCACAACTTGGTTCAATGGGTAGCCTCACCATGAAATCACAGCTTCAGATCACTGTCATCTCAGCAAAACTTAAGGAAAATAAGAAGAATTGGTTTGGACCAAGTCCTTACGTAGAGGTCACAGTAGATGGACAGTCAAAGAAGACAGA
AAAATGCAACAACACAAACAGTCCCAAGTGGAAGCAACCCCTTACAGTGAGGCTGAACCGTCTGAGCCCAGAAGTGCTGAGGTGACGAGGAAGCCCAAGGCTGCTGTTCCTTCTGTGAACAAGAGGCCCAAGAAAGAGACTAAGAAGAAG
CGGTAGAAGAGGAGGCCTGAGGAGCTGGGCGGGCAGGGAGAGGGTCTTGGGGACAGCCCTCCTGGGAATCTACATTGTGTTCCCCCGCATTCCAGGCTCAGGGTCTGAGGAGGCTGTGACGCCCTATGACCGCAGAGATCTAGACAGTCG
TAACAGTCCCCAGGCTCCAGCTGGGCAATCCACCACTTCCTCTTCCTTCTGCTTCTGTGACGGTTTAGAGTCAAGGGGGCTGAAACACACTGTGAGCATAGACTGTATTAGGTTTGTTCAGAAGCCGGGTCAGCTCACAGAGTCACATTT
TCTTGCTTAGTCATGTGTCCCTCCTTGAGTTGCCCCCTCCTTGTGGGTTTACACTACATTTGGGAGTCATTGTCTAATGCTGACAAGCACACCCTCTCCCATTATTTGTGCACTACAGATCTCCTCCTGATCAGTCACCTTTGTTGCTGC
TGTGTAGACAGAGCCAGGCCTCACCTGTTTGTTTAGGCCAAGATGCCATGGACATGCAGCGTTAGTGATCCCACTAGCTGTGACAGCCAGGCCCAGAAAATGCCTGGCGTGAGAGCCAGCAGACAGCCAGGCCAGGGTAGGCAGTGCCTG
CTTCTGCTCCATCAGGTGCAGGGGATTTGGCTGAAGGCGTGCATATTTCCTGGGCACAAACTTCCTGAGCCTCTGAAATGGGAGGCTCGTCAATTTCAGACCAACCTCTTTTCAACCCATCATAGCACGTTCAAGGTGTGCCTTTTACTT
CTACCTGTACATCCCCCATCCCTTCAATTCTTTCATTCCCTGACCAGTGAGAGGGTTCCTGGGGGAAGTATGGTGAATAAACTGACATGCATGCTTCAGAA

>ITCH_MANBAL_ENST00000374864_ENST00000373605_32996598_35944710 length=1378nt 
 Breakpoint=425nt
GCGCTCAGGCGCCTGCGCTTTAGCTGCTAACTCGCTCTAGTAGCTGTGGTCGGGGCTCGGGACCGGCTGCCATCTTAGTCTAGGGACTGAGGAGTCGCCGCCGCCCCGAGTCCCGGTACCATGCATTTCACGGTGGCCTTGTGGAGACAA
CGCCTTAACCCAAGGAAGTGACTCAAACTGTGAGAACTTCAGGTTTTCCAACCTATTGGTGGTATGTCTGACAGTGGATCACAACTTGGTTCAATGGGTAGCCTCACCATGAAATCACAGCTTCAGATCACTGTCATCTCAGCAAAACTT
AAGGAAAATAAGAAGAATTGGTTTGGACCAAGTCCTTACGTAGAGGTCACAGTAGATGGACAGTCAAAGAAGACAGAAAAATGCAACAACACAAACAGTCCCAAGTGGAAGCAACCCCTTACAGTGAGGCTGAACCGTCTGAGCCCAGAA
GTGCTGAGGTGACGAGGAAGCCCAAGGCTGCTGTTCCTTCTGTGAACAAGAGGCCCAAGAAAGAGACTAAGAAGAAGCGGTAGAAGAGGAGGCCTGAGGAGCTGGGCGGGCAGGGAGAGGGTCTTGGGGACAGCCCTCCTGGGAATCTAC
ATTGTGTTCCCCCGCATTCCAGGCTCAGGGTCTGAGGAGGCTGTGACGCCCTATGACCGCAGAGATCTAGACAGTCGTAACAGTCCCCAGGCTCCAGCTGGGCAATCCACCACTTCCTCTTCCTTCTGCTTCTGTGACGGTTTAGAGTCA
AGGGGGCTGAAACACACTGTGAGCATAGACTGTATTAGGTTTGTTCAGAAGCCGGGTCAGCTCACAGAGTCACATTTTCTTGCTTAGTCATGTGTCCCTCCTTGAGTTGCCCCCTCCTTGTGGGTTTACACTACATTTGGGAGTCATTGT
CTAATGCTGACAAGCACACCCTCTCCCATTATTTGTGCACTACAGATCTCCTCCTGATCAGTCACCTTTGTTGCTGCTGTGTAGACAGAGCCAGGCCTCACCTGTTTGTTTAGGCCAAGATGCCATGGACATGCAGCGTTAGTGATCCCA
CTAGCTGTGACAGCCAGGCCCAGAAAATGCCTGGCGTGAGAGCCAGCAGACAGCCAGGCCAGGGTAGGCAGTGCCTGCTTCTGCTCCATCAGGTGCAGGGGATTTGGCTGAAGGCGTGCATATTTCCTGGGCACAAACTTCCTGAGCCTC
TGAAATGGGAGGCTCGTCAATTTCAGACCAACCTCTTTTCAACCCATCATAGCACGTTCAAGGTGTGCCTTTTACTTCTACCTGTACATCCCCCATCCCTTCAATTCTTTCATTCCCTGACCAGTGAGAGGGTTCCTGGGGGAAGTATGG
TGAATAAACTGACATGCATGCTTCAGAA

>ITCH_MANBAL_ENST00000374864_ENST00000397150_32996598_35944710 length=425nt 
 Breakpoint=425nt
GCGCTCAGGCGCCTGCGCTTTAGCTGCTAACTCGCTCTAGTAGCTGTGGTCGGGGCTCGGGACCGGCTGCCATCTTAGTCTAGGGACTGAGGAGTCGCCGCCGCCCCGAGTCCCGGTACCATGCATTTCACGGTGGCCTTGTGGAGACAA
CGCCTTAACCCAAGGAAGTGACTCAAACTGTGAGAACTTCAGGTTTTCCAACCTATTGGTGGTATGTCTGACAGTGGATCACAACTTGGTTCAATGGGTAGCCTCACCATGAAATCACAGCTTCAGATCACTGTCATCTCAGCAAAACTT
AAGGAAAATAAGAAGAATTGGTTTGGACCAAGTCCTTACGTAGAGGTCACAGTAGATGGACAGTCAAAGAAGACAGAAAAATGCAACAACACAAACAGTCCCAAGTGGAAGCAACCCCTTACAGT

>ITCH_MANBAL_ENST00000374864_ENST00000397151_32996598_35944710 length=1378nt 
 Breakpoint=425nt
GCGCTCAGGCGCCTGCGCTTTAGCTGCTAACTCGCTCTAGTAGCTGTGGTCGGGGCTCGGGACCGGCTGCCATCTTAGTCTAGGGACTGAGGAGTCGCCGCCGCCCCGAGTCCCGGTACCATGCATTTCACGGTGGCCTTGTGGAGACAA
CGCCTTAACCCAAGGAAGTGACTCAAACTGTGAGAACTTCAGGTTTTCCAACCTATTGGTGGTATGTCTGACAGTGGATCACAACTTGGTTCAATGGGTAGCCTCACCATGAAATCACAGCTTCAGATCACTGTCATCTCAGCAAAACTT
AAGGAAAATAAGAAGAATTGGTTTGGACCAAGTCCTTACGTAGAGGTCACAGTAGATGGACAGTCAAAGAAGACAGAAAAATGCAACAACACAAACAGTCCCAAGTGGAAGCAACCCCTTACAGTGAGGCTGAACCGTCTGAGCCCAGAA
GTGCTGAGGTGACGAGGAAGCCCAAGGCTGCTGTTCCTTCTGTGAACAAGAGGCCCAAGAAAGAGACTAAGAAGAAGCGGTAGAAGAGGAGGCCTGAGGAGCTGGGCGGGCAGGGAGAGGGTCTTGGGGACAGCCCTCCTGGGAATCTAC
ATTGTGTTCCCCCGCATTCCAGGCTCAGGGTCTGAGGAGGCTGTGACGCCCTATGACCGCAGAGATCTAGACAGTCGTAACAGTCCCCAGGCTCCAGCTGGGCAATCCACCACTTCCTCTTCCTTCTGCTTCTGTGACGGTTTAGAGTCA
AGGGGGCTGAAACACACTGTGAGCATAGACTGTATTAGGTTTGTTCAGAAGCCGGGTCAGCTCACAGAGTCACATTTTCTTGCTTAGTCATGTGTCCCTCCTTGAGTTGCCCCCTCCTTGTGGGTTTACACTACATTTGGGAGTCATTGT
CTAATGCTGACAAGCACACCCTCTCCCATTATTTGTGCACTACAGATCTCCTCCTGATCAGTCACCTTTGTTGCTGCTGTGTAGACAGAGCCAGGCCTCACCTGTTTGTTTAGGCCAAGATGCCATGGACATGCAGCGTTAGTGATCCCA
CTAGCTGTGACAGCCAGGCCCAGAAAATGCCTGGCGTGAGAGCCAGCAGACAGCCAGGCCAGGGTAGGCAGTGCCTGCTTCTGCTCCATCAGGTGCAGGGGATTTGGCTGAAGGCGTGCATATTTCCTGGGCACAAACTTCCTGAGCCTC
TGAAATGGGAGGCTCGTCAATTTCAGACCAACCTCTTTTCAACCCATCATAGCACGTTCAAGGTGTGCCTTTTACTTCTACCTGTACATCCCCCATCCCTTCAATTCTTTCATTCCCTGACCAGTGAGAGGGTTCCTGGGGGAAGTATGG
TGAATAAACTGACATGCATGCTTCAGAA

>ITCH_MANBAL_ENST00000374864_ENST00000397152_32996598_35944710 length=1378nt 
 Breakpoint=425nt
GCGCTCAGGCGCCTGCGCTTTAGCTGCTAACTCGCTCTAGTAGCTGTGGTCGGGGCTCGGGACCGGCTGCCATCTTAGTCTAGGGACTGAGGAGTCGCCGCCGCCCCGAGTCCCGGTACCATGCATTTCACGGTGGCCTTGTGGAGACAA
CGCCTTAACCCAAGGAAGTGACTCAAACTGTGAGAACTTCAGGTTTTCCAACCTATTGGTGGTATGTCTGACAGTGGATCACAACTTGGTTCAATGGGTAGCCTCACCATGAAATCACAGCTTCAGATCACTGTCATCTCAGCAAAACTT
AAGGAAAATAAGAAGAATTGGTTTGGACCAAGTCCTTACGTAGAGGTCACAGTAGATGGACAGTCAAAGAAGACAGAAAAATGCAACAACACAAACAGTCCCAAGTGGAAGCAACCCCTTACAGTGAGGCTGAACCGTCTGAGCCCAGAA
GTGCTGAGGTGACGAGGAAGCCCAAGGCTGCTGTTCCTTCTGTGAACAAGAGGCCCAAGAAAGAGACTAAGAAGAAGCGGTAGAAGAGGAGGCCTGAGGAGCTGGGCGGGCAGGGAGAGGGTCTTGGGGACAGCCCTCCTGGGAATCTAC
ATTGTGTTCCCCCGCATTCCAGGCTCAGGGTCTGAGGAGGCTGTGACGCCCTATGACCGCAGAGATCTAGACAGTCGTAACAGTCCCCAGGCTCCAGCTGGGCAATCCACCACTTCCTCTTCCTTCTGCTTCTGTGACGGTTTAGAGTCA
AGGGGGCTGAAACACACTGTGAGCATAGACTGTATTAGGTTTGTTCAGAAGCCGGGTCAGCTCACAGAGTCACATTTTCTTGCTTAGTCATGTGTCCCTCCTTGAGTTGCCCCCTCCTTGTGGGTTTACACTACATTTGGGAGTCATTGT
CTAATGCTGACAAGCACACCCTCTCCCATTATTTGTGCACTACAGATCTCCTCCTGATCAGTCACCTTTGTTGCTGCTGTGTAGACAGAGCCAGGCCTCACCTGTTTGTTTAGGCCAAGATGCCATGGACATGCAGCGTTAGTGATCCCA
CTAGCTGTGACAGCCAGGCCCAGAAAATGCCTGGCGTGAGAGCCAGCAGACAGCCAGGCCAGGGTAGGCAGTGCCTGCTTCTGCTCCATCAGGTGCAGGGGATTTGGCTGAAGGCGTGCATATTTCCTGGGCACAAACTTCCTGAGCCTC
TGAAATGGGAGGCTCGTCAATTTCAGACCAACCTCTTTTCAACCCATCATAGCACGTTCAAGGTGTGCCTTTTACTTCTACCTGTACATCCCCCATCCCTTCAATTCTTTCATTCCCTGACCAGTGAGAGGGTTCCTGGGGGAAGTATGG
TGAATAAACTGACATGCATGCTTCAGAA

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Fusion Protein Sequence for ITCH_MANBAL

In-frame Fusion Protein Sequences.

>ITCH_MANBAL_ENST00000262650_ENST00000397156_32996598_35944710 length=118nt
MPWTCSVSDPTSCDSQAQKMPGVRASRQPGQGRQCLLLLHQVQGIWLKACIFPGHKLPEPLKWEARQFQTNLFSTHHSTFKVCLLLLPVHPPSLQFFHSLTSERVPGGSMVNKLTCML

>ITCH_MANBAL_ENST00000374864_ENST00000397156_32996598_35944710 length=214nt
MSDSGSQLGSMGSLTMKSQLQITEPPKMNPVVEPLSWMLGTWLSDPPGAGTYPTLQPFQYLEEVHISHVGQPMLNFSFNSFHPDTRKPMHRECGFIRLKPDTNKVAFVSAQNTGVVEVEEGEVNGQELCIASHSIARISFAKEPHVEQVS
PALLPARSCLLFAAVCGVSLFLFREITRKFRLNSEGKLEQTVSMATTTQPMTQHLHVTYKKVTP

N-Truncated Protein (5UTR-3CDS) Sequences

C-Truncated Protein (5CDS-3UTR) Sequences

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Personalized Fusion Protein Sequence for ITCH_MANBAL

TCGA Kinase/DNA-binding Domain Mutated Fusion Protein Sequences

Num

Gene Group

Domain Loci

Fusion Protein ID

Fusion Gene Name

Partner

Mutated Residue in WT Protein

Seq. Length

Mutated Residue in Fusion Protein

CCLE Kinase/DNA-binding Domain Mutated Fusion Protein Sequences

Num

Gene Group

Domain Loci

Fusion Protein ID

Fusion Gene Name

Partner

Mutated Residue in WT Protein

Seq. Length

Mutated Residue in Fusion Protein

TCGA All Mutated Fusion Protein Sequences

Fusion Protein ID

Sample ID

Mutated Partner

AAchange in WT

Seq. Length

AAchange in Fusion

CCLE All Mutated Fusion Protein Sequences

Fusion Protein ID

Sample ID

Mutated Partner

AAchange in WT

Seq. Length

AAchange in Fusion

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Fusion Gene Exprssed Samples for ITCH_MANBAL

RNA-seq based fusion gene expressed samples.

Source	Study	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB		COAD	TCGA-CM-6170-01A	ITCH	chr20	32996598	-	MANBAL	chr20	0	+
ChimerDB		COAD	TCGA-CM-6170-01A	ITCH	chr20	32996598	+	MANBAL	chr20	32996598	+
WashU		COAD	TCGA-CM-6170-01A	ITCH	chr20	32996598	+	MANBAL	chr20	35944711	+

DNA-seq based fusion gene expressed samples.

Source

Study

Disease

Sample

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

SV type

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Related Drugs for ITCH_MANBAL

PubMed Abstract Search With ['A-B' AND 'drug'], ['A::B' AND 'drug']
* For more details on the Studied, Reported, Approved Drugs targeting this fusion gene, Go to FusionPub.

PMID

Fusion Gene Name

Drug

Study Title

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status