Home

Download

Statistics

Examples

About

Contact

	Fusion Gene Summary
	Fusion Gene Breakpoints
	Tumorigenic MoA (Mechanism of Action) Scenarios of Fusion Geness
	Fusion Genomic Features
	Fusion Gene ORF Annotations
	Fusion Protein Retained/Non-Retained Functional Features
	Fusion Transcript Sequences
	Fusion Protein Sequences
	Personalized Fusion Protein Sequences
	Fusion Gene Expressed Samples
	Related Drugs

Fusion gene:BCAR3_ODF3L2 (FusionGDB2 ID:HG8412TG284451)

Fusion Gene Summary for BCAR3_ODF3L2

Fusion gene summary

Fusion gene information	Fusion gene name: BCAR3_ODF3L2
	Fusion gene ID: hg8412tg284451
		Hgene	Tgene
	Gene symbol	BCAR3	ODF3L2
	Gene ID	8412	284451
	Gene name	BCAR3 adaptor protein, NSP family member	CIMAP1 family member D
	Synonyms	AND-34\|MIG7\|NSP2\|SH2D3B	C19orf19\|ODF3L2
	Cytomap	1p22.1	19p13.3
	Type of gene	protein-coding	protein-coding
	Description	breast cancer anti-estrogen resistance protein 3BCAR3, NSP family adaptor proteinSH2 domain-containing protein 3Bbreast cancer anti-estrogen resistance 3breast cancer antiestrogen resistance 3 proteindJ1033H22.2 (breast cancer anti-estrogen resistanc	protein CIMAP1Douter dense fiber of sperm tails 3 like 2outer dense fiber protein 3-like protein 2
	Modification date	20240403	20240305
	UniProtAcc	.	.
	Ensembl transtripts involved in fusion gene	ENST00000370243, ENST00000370244, ENST00000260502, ENST00000370247, ENST00000466632, ENST00000539242,
Fusion gene scores	* DoF score	* DoF score (Degree of Frequency) = # partners X # break points X # disease types 20 X 23 X 17=7820	* DoF score (Degree of Frequency) = # partners X # break points X # disease types 3 X 4 X 1=12
	# samples	36	6
	** MAII score	** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score10) log2(36/782010)=-4.44109979586504 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score10) log2(6/1210)=2.32192809488736 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0
Context	PubMed: BCAR3 [Title/Abstract] AND ODF3L2 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	BCAR3(94107859)-ODF3L2(467762), # samples:1

Fusion gene breakpoints across BCAR3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across ODF3L2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Top

Fusion Gene Breakpoints for BCAR3_ODF3L2

RNA-seq based exon junction arranged fusion gene breakpoints from 8 resources (TCGA, CCLE, cBioPortal, GenBank, ChimerDB, ChimerKB, ChildHoodFusions, and GTEx). For the expressed sample information, go to Fusion Gene Sample section.

Hgene	Hchr	Hbp	Tgene	Tchr	Tbp
BCAR3	chr1	94107859	ODF3L2	chr19	467762
BCAR3	chr1	94107860	ODF3L2	chr19	467762

DNA-seq based exon junction arranged fusion gene breakpoints from dbVar. For the expressed sample information, go to Fusion Gene Sample section.

Hgene

Hchr

Hbp

Tgene

Tchr

Tbp

SV type

Top

Tumorigenic MoA (Mechanism of Action) Scenarios of Fusion Genes for BCAR3_ODF3L2

To generate these tumorigenic scenario annotations, we implemented a deduction-first, retrieval-later computational framework. The pipeline first applies rule-guided reasoning across ten core mechanistic categories (M1–M10) derived from fusion gene biology to infer candidate mechanisms, tumorigenic scenarios, targeting points, and targeting backgrounds. To ensure empirical accountability, a governed Python workflow retrieves literature candidates via NCBI E-utilities and Europe PMC using tiered searches. Using JSON Schema-constrained LLM evidence judges (GPT-5.6 Luna and Terra), retrieved articles are evaluated for specificity and confidence without de novo PMID generation. This produces two distinct versions: a strict version restricted to high- or medium-confidence fusion-specific evidence, and an extended version incorporating broader gene-, pathway-, and contextual evidence.

* We have 10 tumorigenic mechanism categories of fusion genes as shown below.

Constitutively Active Kinases, Catalytic Domain Dysregulation, & Transmembrane Ligand Fusions	Aberrant Chimeric Transcription Factor / Fusion Transcription Factor Activity	Epigenetic Reprogramming / Histone Modifier Dysregulation	Chromatin Remodeling Dysregulation	Condensate-Driven Transcriptional Rewiring / LLP	Promoter / Enhancer Hijacking	Dominant-Negative Antagonism	Cell Cycle / Checkpoint Bypass / RNA Processing Dysregulation	Subcellular Mislocalization / Spatial Dysregulation	Nuclear Body / Sub-organellar Architecture Disruption & Differentiation Blockade

* Strict version: Restricted to high- or medium-confidence fusion-specific evidence.

Fusion Gene Name	Mechanism Category	Mechanism PubMed	Tumorigenic Scenarios	Tumorigenic Scenario PubMed	Targeting Points	Targeting PubMed	Mechanism Background	Mechanism Background PubMed
BCAR3-ODF3L2	Promoter / Enhancer Hijacking M6		Promoter swap alters outer dense fiber protein 3-like 2 expression.		Standard chemotherapy regimens		Solid tumors

* Extended version: Includes all strict-level fusion evidence plus broader gene-, pathway-, and low-confidence contextual evidence.

Fusion Gene Name	Mechanism Category	Mechanism PubMed	Tumorigenic Scenarios	Tumorigenic Scenario PubMed	Targeting Points	Targeting PubMed	Mechanism Background	Mechanism Background PubMed
BCAR3-ODF3L2	Promoter / Enhancer Hijacking		Promoter swap alters outer dense fiber protein 3-like 2 expression.		Standard chemotherapy regimens		Solid tumors

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Top

Fusion Genomic Features for BCAR3_ODF3L2

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence) of In-frame fusion genes. FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
BCAR3	chr1	94107859	-	ODF3L2	chr19	467762	-	2.75e-05	1.00e+00

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence) of 5UTR-3CSD fusion genes (N-truncated cases).

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence) of 5CDS-3UTR fusion genes (C-truncated cases).

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of six genomic regulatory feature tracks across a ±5 kb window centered on the fusion breakpoints. We input the breakpoint sequences into AlphaGenome and obtained predicted genome tracks at single-base-pair resolution for each modality by running a single forward pass over the reference sequence. Specifically, for each breakpoint, AlphaGenome processed and returned predicted track data across diverse modalities, which were then averaged across all tracks within each output type and visualized across the ±5 kb window. The left panel shows the 5'-gene breakpoint ±5 kb area, and the right panel shows the 3'-gene breakpoint area, with tracks grouped by category: chromatin accessibility (DNase-seq, ATAC-seq), active transcription (RNA-seq, CAGE), and chromatin binding (ChIP-Histone, ChIP-TF).

Top

Fusion Gene ORF Annotations for BCAR3_ODF3L2

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
Frame-shift	ENST00000370243	ENST00000315489	BCAR3	chr1	94107859	-	ODF3L2	chr19	467762	-
Frame-shift	ENST00000370243	ENST00000382696	BCAR3	chr1	94107859	-	ODF3L2	chr19	467762	-
Frame-shift	ENST00000370244	ENST00000315489	BCAR3	chr1	94107859	-	ODF3L2	chr19	467762	-
Frame-shift	ENST00000370244	ENST00000382696	BCAR3	chr1	94107859	-	ODF3L2	chr19	467762	-
In-frame	ENST00000260502	ENST00000315489	BCAR3	chr1	94107859	-	ODF3L2	chr19	467762	-
In-frame	ENST00000260502	ENST00000382696	BCAR3	chr1	94107859	-	ODF3L2	chr19	467762	-

ORFfinder Result Based On The Fusion Transcript Sequences of the In-frame Fusion Genes.

Henst	Tenst	Hgene	Hchr	Hbp	Tgene	Tchr	Tbp	Seq length (transcript)	Seq length (peptide)
ENST00000260502	ENST00000315489	BCAR3	chr1	94107859	ODF3L2	chr19	467762	600	1127
ENST00000260502	ENST00000382696	BCAR3	chr1	94107859	ODF3L2	chr19	467762	600	236

ORFfinder Result Based On The Fusion Transcript Sequences of the 5UTR-3CDS Fusion Genes for N-Truncated Protein Search.

Henst

Tenst

Hgene

Hchr

Hbp

Tgene

Tchr

Tbp

Seq length
(transcript)

Seq length
(peptide)

ORFfinder Result Based On The Fusion Transcript Sequences of the 5CDS-3UTR Fusion Genes for C-Truncated Protein Search.

Henst

Tenst

Hgene

Hchr

Hbp

Tgene

Tchr

Tbp

Seq length
(transcript)

Seq length
(peptide)

DeepORF Prediction of The Coding Potential Based on The Fusion Transcript Sequence of In-frame Fusion Genes. DeepORF is a Coding Potential Classifier Based on Convolutional Neural Network by Comparing the Real Ribo-seq Data. If the No-coding Score < 0.5 and Coding Score > 0.5, Then The In-frame Fusion Transcript is Predicted as Being Likely Translated.

Henst	Tenst	Hgene	Hchr	Hbp	Tgene	Tchr	Tbp	No-coding score	Coding score
ENST00000260502	ENST00000315489	BCAR3	chr1	94107859	ODF3L2	chr19	467762	1.85e-02	9.81e-01
ENST00000260502	ENST00000382696	BCAR3	chr1	94107859	ODF3L2	chr19	467762	1.58e-02	9.84e-01

DeepORF Prediction of The Coding Potential Based on The Fusion Transcript Sequence of 5UTR-3CDS Fusion Genes (Potential N-Truncated Proteins).

Henst

Tenst

Hgene

Hchr

Hbp

Tgene

Tchr

Tbp

No-coding score

Coding score

DeepORF Prediction of The Coding Potential Based on The Fusion Transcript Sequence of 5CDS-3UTR Fusion Genes (Potential C-Truncated Proteins).

Henst

Tenst

Hgene

Hchr

Hbp

Tgene

Tchr

Tbp

No-coding score

Coding score

Top

Fusion Protein Retained/Non-Retained Functional Features for BCAR3_ODF3L2

Protein Level Annotation from FGviewer
* Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at download page. Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features (visualization across fusion protein length).

BCAR3_ODF3L2_chr1-94107859_chr19-467762.png

- In-frame and retained protein feature among the 13 regional features (texts).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

BCAR3

chr1:94107859

chr19:467762

ENST00000260502

O75815

79_94

119.0

826.0

Compositional bias

Polar residues

Hgene

BCAR3

chr1:94107859

chr19:467762

ENST00000260502

O75815

95_106

119.0

826.0

Compositional bias

Basic and acidic residues

Hgene

BCAR3

chr1:94107859

chr19:467762

ENST00000260502

O75815

40_106

119.0

826.0

Region

Disordered

Tgene

ODF3L2

chr1:94107859

chr19:467762

ENST00000315489

Q3SX64

280_289

78.33333333333333

290.0

Compositional bias

Basic residues

Tgene

ODF3L2

chr1:94107859

chr19:467762

ENST00000315489

Q3SX64

108_136

78.33333333333333

290.0

Region

Disordered

Tgene

ODF3L2

chr1:94107859

chr19:467762

ENST00000315489

Q3SX64

181_211

78.33333333333333

290.0

Region

Disordered

Tgene

ODF3L2

chr1:94107859

chr19:467762

ENST00000315489

Q3SX64

265_289

78.33333333333333

290.0

Region

Disordered

Tgene

ODF3L2

chr1:94107859

chr19:467762

ENST00000315489

Q3SX64

122_148

78.33333333333333

290.0

Repeat

Note=STPGR 1

Tgene

ODF3L2

chr1:94107859

chr19:467762

ENST00000315489

Q3SX64

202_227

78.33333333333333

290.0

Repeat

Note=STPGR 2

Tgene

ODF3L2

chr1:94107859

chr19:467762

ENST00000315489

Q3SX64

238_263

78.33333333333333

290.0

Repeat

Note=STPGR 3

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

BCAR3

chr1:94107859

chr19:467762

ENST00000260502

O75815

154_253

119.0

826.0

Domain

SH2

Hgene

BCAR3

chr1:94107859

chr19:467762

ENST00000260502

O75815

548_818

119.0

826.0

Domain

Ras-GEF

- Retained PPIs in in-frame fusion.

Partner

Hgene

Hbp

Tgene

Tbp

ENST

UniProt

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Hgene

Hbp

Tgene

Tbp

ENST

UniProt

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Fusion Transcript Sequence for BCAR3_ODF3L2

In-frame Fusion Transcript Sequences.

>BCAR3_ODF3L2_ENST00000260502_ENST00000315489_94107859_467762 length=1733nt 
 Breakpoint=600nt
GCCTGCTGCTGGCCGGGCGGGGGACGGGGCCGGGACCGGAGCCGGAGCTGCGGGGCGCACCGGCTAGACGCGCGCGGGATTCTCGGCGGGCACGCCCCGCGGACCATGAGCGTCCCCAGCTCCGGGAGCAGCCGCGGCGCGGGCGGTGCG
AGGCCGGCCGCGCGGCGCCTTTGAGCCCCAGCCGGAGGTCCAGAGATCCTGAGAGCCCGAGCGCCCAGCGCCGCGCCGGGAGAGTTGAGAATTATGGCTGCAGGAAAATTTGCAAGCCTTCCCAGAAACATGCCGGTGAATCACCAGTTC
CCCCTGGCCTCATCCATGGACCTTCTGAGCAGCAGGTCCCCTCTCGCTGAGCATCGCCCAGATGCCTATCAAGATGTGTCTATACATGGCACCCTTCCACGGAAGAAAAAAGGTCCTCCTCCCATAAGGTCCTGTGATGACTTCAGTCAC
ATGGGCACCCTCCCCCACTCCAAATCCCCACGGCAGAACTCGCCTGTGACCCAGGATGGCATCCAGGAGAGCCCATGGCAGGACCGGCACGGCGAAACCTTCACCTTCAGGGATCCACATCTTCTGGACCCAACTGTGGAATATGTGAAG
CACCACCTCAGGACACCAGCCCGGGCCCCATCTACTTCTTGGACCCCAAAGTCACACGCTTTGGCCGCAGCTGCACCCCTGCCTACTCCATGCAGGGCCGGGCCAAGTCTCGGGGTCCGGAGGTGACGCCAGGCCCTGGGGCCTACAGCC
CAGAGAAGGTGCCCCCTGTGCGCCATCGGACACCGCCGGCTTTCACCCTGGGCTGCCGCCTCCCCCTGAAGCCCCTGGACACCTCAGCCCCTGCCCCTAATGCCTACACCATGCCCCCTCTGTGGGGCTCACAGATCTTCACCAAGCCCA
GCAGCCCCAGCTACACGGTGGTGGGCCGCACCCCCCCCGCCCGCCCCCCGCAGGATCCTGCTGAGATACCAGGCCCGGGCCAGTACGACAGCCCGGACGCAAACACCTACCGCCAGCGCCTGCCTGCCTTCACCATGCTGGGGCGGCCCC
GGGCCCCGCGACCCCTGGAGGAGACCCCCGGCCCTGGCGCCCACTGCCCAGAGCAGGTCACCGTGAACAAAGCCAGGGCTCCAGCGTTCTCTATGGGCATCCGCCACTCGAAACGGGCCAGCACCATGGCCGCCACCACGCCCTCCCGGC
CTGCGGGGCACAGGCTGCCCGGCCGCTGCTGCTAGGCCAGGCCTGTTTCCCACACAGTGAACGGGGGGCTGGCGGGCCTCTCCTGGGGCCTGGCTTTGGCTGGAGGGGCTAGAAGGCGAGAGGGGCTGGGAAAGGAGTCTTCCCTCCCCT
TTCCTGAACTGTCCAGGTCCTTCTAGGACACCTGATCCTTCCAGTCCCTGGGGGCTGTGACCCATGGCCCTGTGCAGGGTGCAGGGTGAGTCTCCTTCCAGTGCCCCAGTTTCTTCCAGGTCACGCCAGGCCAGGCCAGGCCAGGTGGGG
AAAGGGACACCTTCCGGCCCTCCCCAGTAGCTGGCTGGAGATGGAGCTTCCTGTGTCCCAGAACTCGGCGTCCAGCTCCACTAGGGCCTGGATCCCCATCACAGCTTGGGTTAGCCCCGGTCCCAGCCCAAACTCAGGCTGGAGGCAGCC
CCGAGGCCTGTGCCTTTCCCACTCCACCTTCTACAGTTGCTTAGCCAATAAACCTTTCCTGGGCTGGAGAGCTGTCAGCATCA

>BCAR3_ODF3L2_ENST00000260502_ENST00000382696_94107859_467762 length=1612nt 
 Breakpoint=600nt
GCCTGCTGCTGGCCGGGCGGGGGACGGGGCCGGGACCGGAGCCGGAGCTGCGGGGCGCACCGGCTAGACGCGCGCGGGATTCTCGGCGGGCACGCCCCGCGGACCATGAGCGTCCCCAGCTCCGGGAGCAGCCGCGGCGCGGGCGGTGCG
AGGCCGGCCGCGCGGCGCCTTTGAGCCCCAGCCGGAGGTCCAGAGATCCTGAGAGCCCGAGCGCCCAGCGCCGCGCCGGGAGAGTTGAGAATTATGGCTGCAGGAAAATTTGCAAGCCTTCCCAGAAACATGCCGGTGAATCACCAGTTC
CCCCTGGCCTCATCCATGGACCTTCTGAGCAGCAGGTCCCCTCTCGCTGAGCATCGCCCAGATGCCTATCAAGATGTGTCTATACATGGCACCCTTCCACGGAAGAAAAAAGGTCCTCCTCCCATAAGGTCCTGTGATGACTTCAGTCAC
ATGGGCACCCTCCCCCACTCCAAATCCCCACGGCAGAACTCGCCTGTGACCCAGGATGGCATCCAGGAGAGCCCATGGCAGGACCGGCACGGCGAAACCTTCACCTTCAGGGATCCACATCTTCTGGACCCAACTGTGGAATATGTGAAG
CACCACCTCAGGACACCAGCCCGGGCCCCATCTACTTCTTGGACCCCAAAGTCACACGCTTTGGCCGCAGCTGCACCCCTGCCTACTCCATGCAGGGCCGGGCCAAGTCTCGGGGTCCGGAGGTGACGCCAGGCCCTGGGGCCTACAGCC
CAGAGAAGGTGCCCCCTGTGCGCCATCGGACACCGCCGGCTTTCACCCTGGGCTGCCGCCTCCCCCTGAAGCCCCTGGACACCTCAGCCCCTGCCCCTAATGCCTACACCATGCCCCCTCTGTGGGGCTCACAGATCTTCACCAAGCCCA
GCAGCCCCAGCTACACGGTGGTGGGCCGCACCCCCCCCGCCCGCCCCCCGCAGGATCCTGCTGAGATACCAGGCCCGGGCCAGTACGACAGCCCGGACGCAAACACCTACCGCCAGCGCCTGCCTGCCTTCACCATGCTGGGGCGGCCCC
GGGCCCCGCGACCCCTGGAGGAGACCCCCGGCCCTGGCGCCCACTGCCCAGAGCAGGTCACCGTGAACAAAGCCAGGGCTCCAGCGTTCTCTATGGGCATCCGCCACTCGAAACGGGCCAGCACCATGGCCGCCACCACGCCCTCCCGGC
CTGCGGGGCACAGGCTGCCCGGCCGCTGCTGCTAGGCCAGGCCTGTTTCCCACACAGTGAACGGGGGGCTGGCGGGCCTCTCCTGGGGCCTGGCTTTGGCTGGAGGGGCTAGAAGGCGAGAGGGGCTGGGAAAGGAGTCTTCCCTCCCCT
TTCCTGAACTGTCCAGGTCCTTCTAGGACACCTGATCCTTCCAGTCCCTGGGGGCTGTGACCCATGGCCCTGTGCAGGGTGCAGGGTGAGTCTCCTTCCAGTGCCCCAGTTTCTTCCAGGTCACGCCAGGCCAGGCCAGGCCAGGTGGGG
AAAGGGACACCTTCCGGCCCTCCCCAGTAGCTGGCTGGAGATGGAGCTTCCTGTGTCCCAGAACTCGGCGTCCAGCTCCACTAGGGCCTGGATCCCCATCACAGCTTGGGTT

N-Truncated Transcript (5UTR-3CDS) Sequences

C-Truncated Transcript (5CDS-3UTR) Sequences

Top

Fusion Protein Sequence for BCAR3_ODF3L2

In-frame Fusion Protein Sequences.

>BCAR3_ODF3L2_ENST00000260502_ENST00000315489_94107859_467762 length=1127nt
MPKECSAFHALSAALCCFYHRKSFIGVKGTCSCSSKGFSTTCPAHVDDLTPEQVLDGDVNELMDVVLHHVPEAKLVECIGQELIFLLPNKNFKHRAYASLFRELEETLADLGLSSFGISDTPLEEIFLKVTEDSDSGPLFAGGAQQKREN
VNPRHPCLGPREKAGQTPQDSNVCSPGAPAAHPEGQPPPEPECPGPQLNTGTQLVLQHVQALLVKRFQHTIRSHKDFLAQIVLPATFVFLALMLSIVIPPFGEYPALTLHPWIYGQQYTFFSMDEPGSEQFTVLADVLLNKPGFGNRCLK
EGWLPEYPCGNSTPWKTPSVSPNITQLFQKQKWTQVNPSPSCRCSTREKLTMLPECPEGAGGLPPPQRTQRSTEILQDLTDRNISDFLVKTYPALIRSSLKSKFWVNEQRYGGISIGGKLPVVPITGEALVGFLSDLGRIMNVSGGPITR
EASKEIPDFLKHLETEDNIKVWFNNKGWHALVSFLNVAHNAILRASLPKDRSPEEYGITVISQPLNLTKEQLSEITVLTTSVDAVVAICVIFSMSFVPASFVLYLIQERVNKSKHLQFISGVSPTTYWVTNFLWDIMNYSVSAGLVVGIF
IGFQKKAYTSPENLPALVALLLLYGWAVIPMMYPASFLFDVPSTAYVALSCANLFIGINSSAITFILELFENNRTLLRFNAVLRKLLIVFPHFCLGRGLIDLALSQAVTDVYARFGEEHSANPFHWDLIGKNLFAMVVEGVVYFLLTLLV
QRHFFLSQWIAEPTKEPIVDEDDDVAEERQRIITGGNKTDILRLHELTKIYPGTSSPAVDRLCVGVRPGECFGLLGVNGAGKTTTFKMLTGDTTVTSGDATVAGKSILTNISEVHQNMGYCPQFDAIDELLTGREHLYLYARLRGVPAEE
IEKVANWSIKSLGLTVYADCLAGTYSGGNKRKLSTAIALIGCPPLVLLDEPTTGMDPQARRMLWNVIVSIIREGRAVVLTSHSMEECEALCTRLAIMVKGAFRCMGTIQHLKSKFGDGYIVTMKIKSPKDDLLPDLNPVEQFFQGNFPGS
VQRERHYNMLQFQVSSSSLARIFQLLLSHKDSLLIEEYSVTQTTLDQVFVNFAKQQTESHDLPLHPRAAGASRQAQD

>BCAR3_ODF3L2_ENST00000260502_ENST00000382696_94107859_467762 length=236nt
MAGPARRNLHLQGSTSSGPNCGICEAPPQDTSPGPIYFLDPKVTRFGRSCTPAYSMQGRAKSRGPEVTPGPGAYSPEKVPPVRHRTPPAFTLGCRLPLKPLDTSAPAPNAYTMPPLWGSQIFTKPSSPSYTVVGRTPPARPPQDPAEIPG
PGQYDSPDANTYRQRLPAFTMLGRPRAPRPLEETPGPGAHCPEQVTVNKARAPAFSMGIRHSKRASTMAATTPSRPAGHRLPGRCC

N-Truncated Protein (5UTR-3CDS) Sequences

C-Truncated Protein (5CDS-3UTR) Sequences

Top

Personalized Fusion Protein Sequence for BCAR3_ODF3L2

TCGA Kinase/DNA-binding Domain Mutated Fusion Protein Sequences

Num

Gene Group

Domain Loci

Fusion Protein ID

Fusion Gene Name

Partner

Mutated Residue in WT Protein

Seq. Length

Mutated Residue in Fusion Protein

CCLE Kinase/DNA-binding Domain Mutated Fusion Protein Sequences

Num

Gene Group

Domain Loci

Fusion Protein ID

Fusion Gene Name

Partner

Mutated Residue in WT Protein

Seq. Length

Mutated Residue in Fusion Protein

TCGA All Mutated Fusion Protein Sequences

Fusion Protein ID

Sample ID

Mutated Partner

AAchange in WT

Seq. Length

AAchange in Fusion

CCLE All Mutated Fusion Protein Sequences

Fusion Protein ID

Sample ID

Mutated Partner

AAchange in WT

Seq. Length

AAchange in Fusion

Top

Fusion Gene Exprssed Samples for BCAR3_ODF3L2

RNA-seq based fusion gene expressed samples.

Source	Study	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB		BRCA	TCGA-A7-A5ZV-01A	BCAR3	chr1	94107859	-	ODF3L2	chr19	467762	-
TCGAfusionPortal		BRCA	TCGA-A7-A5ZV-01A	BCAR3	chr1	94107860	-	ODF3L2	chr19	467762	-

DNA-seq based fusion gene expressed samples.

Source

Study

Disease

Sample

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

SV type

Top

Related Drugs for BCAR3_ODF3L2

PubMed Abstract Search With ['A-B' AND 'drug'], ['A::B' AND 'drug']
* For more details on the Studied, Reported, Approved Drugs targeting this fusion gene, Go to FusionPub.

PMID

Fusion Gene Name

Drug

Study Title

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status