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	Fusion Gene Summary
	Fusion Gene Breakpoints
	Tumorigenic MoA (Mechanism of Action) Scenarios of Fusion Geness
	Fusion Genomic Features
	Fusion Gene ORF Annotations
	Fusion Protein Retained/Non-Retained Functional Features
	Fusion Transcript Sequences
	Fusion Protein Sequences
	Personalized Fusion Protein Sequences
	Fusion Gene Expressed Samples
	Related Drugs

Fusion gene:ASAP2_ERI3 (FusionGDB2 ID:HG8853TG79033)

Fusion Gene Summary for ASAP2_ERI3

Fusion gene summary

Fusion gene information	Fusion gene name: ASAP2_ERI3
	Fusion gene ID: hg8853tg79033
		Hgene	Tgene
	Gene symbol	ASAP2	ERI3
	Gene ID	8853	79033
	Gene name	ArfGAP with SH3 domain, ankyrin repeat and PH domain 2	ERI1 exoribonuclease family member 3
	Synonyms	AMAP2\|CENTB3\|DDEF2\|PAG3\|PAP\|Pap-alpha\|SHAG1	PINT1\|PRNPIP
	Cytomap	2p25.1\|2p24	1p34.1
	Type of gene	protein-coding	protein-coding
	Description	arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2PYK2 C terminus-associated proteincentaurin, beta 3development and differentiation-enhancing factor 2paxillin-associated protein with ARF GAP activity 3pyk2 C-terminus-associated p	ERI1 exoribonuclease 3enhanced RNAi three prime mRNA exonuclease homolog 3prion interactor 1prion protein-interacting protein
	Modification date	20240305	20240403
	UniProtAcc	.	.
	Ensembl transtripts involved in fusion gene	ENST00000281419, ENST00000315273, ENST00000491413,
Fusion gene scores	* DoF score	* DoF score (Degree of Frequency) = # partners X # break points X # disease types 18 X 17 X 15=4590	* DoF score (Degree of Frequency) = # partners X # break points X # disease types 10 X 12 X 9=1080
	# samples	30	20
	** MAII score	** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score10) log2(30/459010)=-3.93545974780529 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score10) log2(20/108010)=-2.43295940727611 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: ASAP2 [Title/Abstract] AND ERI3 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	ASAP2(9460466)-ERI3(44687312), # samples:1

Fusion gene breakpoints across ASAP2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across ERI3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Breakpoints for ASAP2_ERI3

RNA-seq based exon junction arranged fusion gene breakpoints from 8 resources (TCGA, CCLE, cBioPortal, GenBank, ChimerDB, ChimerKB, ChildHoodFusions, and GTEx). For the expressed sample information, go to Fusion Gene Sample section.

Hgene	Hchr	Hbp	Tgene	Tchr	Tbp
ASAP2	chr2	9460466	ERI3	chr1	44687312

DNA-seq based exon junction arranged fusion gene breakpoints from dbVar. For the expressed sample information, go to Fusion Gene Sample section.

Hgene

Hchr

Hbp

Tgene

Tchr

Tbp

SV type

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Tumorigenic MoA (Mechanism of Action) Scenarios of Fusion Genes for ASAP2_ERI3

To generate these tumorigenic scenario annotations, we implemented a deduction-first, retrieval-later computational framework. The pipeline first applies rule-guided reasoning across ten core mechanistic categories (M1–M10) derived from fusion gene biology to infer candidate mechanisms, tumorigenic scenarios, targeting points, and targeting backgrounds. To ensure empirical accountability, a governed Python workflow retrieves literature candidates via NCBI E-utilities and Europe PMC using tiered searches. Using JSON Schema-constrained LLM evidence judges (GPT-5.6 Luna and Terra), retrieved articles are evaluated for specificity and confidence without de novo PMID generation. This produces two distinct versions: a strict version restricted to high- or medium-confidence fusion-specific evidence, and an extended version incorporating broader gene-, pathway-, and contextual evidence.

* We have 10 tumorigenic mechanism categories of fusion genes as shown below.

Constitutively Active Kinases, Catalytic Domain Dysregulation, & Transmembrane Ligand Fusions	Aberrant Chimeric Transcription Factor / Fusion Transcription Factor Activity	Epigenetic Reprogramming / Histone Modifier Dysregulation	Chromatin Remodeling Dysregulation	Condensate-Driven Transcriptional Rewiring / LLP	Promoter / Enhancer Hijacking	Dominant-Negative Antagonism	Cell Cycle / Checkpoint Bypass / RNA Processing Dysregulation	Subcellular Mislocalization / Spatial Dysregulation	Nuclear Body / Sub-organellar Architecture Disruption & Differentiation Blockade

* Strict version: Restricted to high- or medium-confidence fusion-specific evidence.

Fusion Gene Name	Mechanism Category	Mechanism PubMed	Tumorigenic Scenarios	Tumorigenic Scenario PubMed	Targeting Points	Targeting PubMed	Mechanism Background	Mechanism Background PubMed
ASAP2-ERI3	Cell Cycle / Checkpoint Bypass / RNA Processing Dysregulation M8		Promoter swap alters ERI3 exoribonuclease expression, modifying non-coding RNA maturation and viral RNA-sensing thresholds.		RNA metabolism modulators; standard chemotherapy		Solid tumors

* Extended version: Includes all strict-level fusion evidence plus broader gene-, pathway-, and low-confidence contextual evidence.

Fusion Gene Name	Mechanism Category	Mechanism PubMed	Tumorigenic Scenarios	Tumorigenic Scenario PubMed	Targeting Points	Targeting PubMed	Mechanism Background	Mechanism Background PubMed
ASAP2-ERI3	Cell Cycle / Checkpoint Bypass / RNA Processing Dysregulation M8		Promoter swap alters ERI3 exoribonuclease expression, modifying non-coding RNA maturation and viral RNA-sensing thresholds.		RNA metabolism modulators; standard chemotherapy		Solid tumors	Evidence level: Indirect gene evidence; Confidence: Medium; PMID: 41540704; Title: [ERI3 expression is elevated in hepatocellular carcinoma and correlates with poor patient prognosis].; PMID: 34760691; Title: Bioinformatics Analysis Using ATAC-seq and RNA-seq for the Identification of 15 Gene Signatures Associated With the Prediction of Prognosis in Hepatocellular Carcinoma.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

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Fusion Genomic Features for ASAP2_ERI3

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence) of In-frame fusion genes. FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
ASAP2	chr2	9460466	+	ERI3	chr1	44687312	-	9.60e-02	9.04e-01

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence) of 5UTR-3CSD fusion genes (N-truncated cases).

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence) of 5CDS-3UTR fusion genes (C-truncated cases).

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of six genomic regulatory feature tracks across a ±5 kb window centered on the fusion breakpoints. We input the breakpoint sequences into AlphaGenome and obtained predicted genome tracks at single-base-pair resolution for each modality by running a single forward pass over the reference sequence. Specifically, for each breakpoint, AlphaGenome processed and returned predicted track data across diverse modalities, which were then averaged across all tracks within each output type and visualized across the ±5 kb window. The left panel shows the 5'-gene breakpoint ±5 kb area, and the right panel shows the 3'-gene breakpoint area, with tracks grouped by category: chromatin accessibility (DNase-seq, ATAC-seq), active transcription (RNA-seq, CAGE), and chromatin binding (ChIP-Histone, ChIP-TF).

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Fusion Gene ORF Annotations for ASAP2_ERI3

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
Frame-shift	ENST00000281419	ENST00000372259	ASAP2	chr2	9460466	+	ERI3	chr1	44687312	-
Frame-shift	ENST00000281419	ENST00000537474	ASAP2	chr2	9460466	+	ERI3	chr1	44687312	-
Frame-shift	ENST00000315273	ENST00000372259	ASAP2	chr2	9460466	+	ERI3	chr1	44687312	-
Frame-shift	ENST00000315273	ENST00000537474	ASAP2	chr2	9460466	+	ERI3	chr1	44687312	-
In-frame	ENST00000281419	ENST00000372257	ASAP2	chr2	9460466	+	ERI3	chr1	44687312	-
In-frame	ENST00000315273	ENST00000372257	ASAP2	chr2	9460466	+	ERI3	chr1	44687312	-

ORFfinder Result Based On The Fusion Transcript Sequences of the In-frame Fusion Genes.

Henst	Tenst	Hgene	Hchr	Hbp	Tgene	Tchr	Tbp	Seq length (transcript)	Seq length (peptide)
ENST00000281419	ENST00000372257	ASAP2	chr2	9460466	ERI3	chr1	44687312	810	635
ENST00000315273	ENST00000372257	ASAP2	chr2	9460466	ERI3	chr1	44687312	810	333

ORFfinder Result Based On The Fusion Transcript Sequences of the 5UTR-3CDS Fusion Genes for N-Truncated Protein Search.

Henst

Tenst

Hgene

Hchr

Hbp

Tgene

Tchr

Tbp

Seq length
(transcript)

Seq length
(peptide)

ORFfinder Result Based On The Fusion Transcript Sequences of the 5CDS-3UTR Fusion Genes for C-Truncated Protein Search.

Henst

Tenst

Hgene

Hchr

Hbp

Tgene

Tchr

Tbp

Seq length
(transcript)

Seq length
(peptide)

DeepORF Prediction of The Coding Potential Based on The Fusion Transcript Sequence of In-frame Fusion Genes. DeepORF is a Coding Potential Classifier Based on Convolutional Neural Network by Comparing the Real Ribo-seq Data. If the No-coding Score < 0.5 and Coding Score > 0.5, Then The In-frame Fusion Transcript is Predicted as Being Likely Translated.

Henst	Tenst	Hgene	Hchr	Hbp	Tgene	Tchr	Tbp	No-coding score	Coding score
ENST00000281419	ENST00000372257	ASAP2	chr2	9460466	ERI3	chr1	44687312	2.70e-03	9.97e-01
ENST00000315273	ENST00000372257	ASAP2	chr2	9460466	ERI3	chr1	44687312	2.70e-03	9.97e-01

DeepORF Prediction of The Coding Potential Based on The Fusion Transcript Sequence of 5UTR-3CDS Fusion Genes (Potential N-Truncated Proteins).

Henst

Tenst

Hgene

Hchr

Hbp

Tgene

Tchr

Tbp

No-coding score

Coding score

DeepORF Prediction of The Coding Potential Based on The Fusion Transcript Sequence of 5CDS-3UTR Fusion Genes (Potential C-Truncated Proteins).

Henst

Tenst

Hgene

Hchr

Hbp

Tgene

Tchr

Tbp

No-coding score

Coding score

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Fusion Protein Retained/Non-Retained Functional Features for ASAP2_ERI3

Protein Level Annotation from FGviewer
* Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at download page. Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features (visualization across fusion protein length).

ASAP2_ERI3_chr2-9460466_chr1-44687312.png

- In-frame and retained protein feature among the 13 regional features (texts).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

ASAP2

chr2:9460466

chr1:44687312

ENST00000281419

O43150

256_283

156.66666666666666

1007.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

ASAP2

chr2:9460466

chr1:44687312

ENST00000281419

O43150

729_752

156.66666666666666

1007.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

ASAP2

chr2:9460466

chr1:44687312

ENST00000281419

O43150

288_300

156.66666666666666

1007.0

Compositional bias

Polar residues

Hgene

ASAP2

chr2:9460466

chr1:44687312

ENST00000281419

O43150

794_823

156.66666666666666

1007.0

Compositional bias

Polar residues

Hgene

ASAP2

chr2:9460466

chr1:44687312

ENST00000281419

O43150

865_886

156.66666666666666

1007.0

Compositional bias

Pro residues

Hgene

ASAP2

chr2:9460466

chr1:44687312

ENST00000281419

O43150

305_397

156.66666666666666

1007.0

Domain

Hgene

ASAP2

chr2:9460466

chr1:44687312

ENST00000281419

O43150

421_543

156.66666666666666

1007.0

Domain

Arf-GAP

Hgene

ASAP2

chr2:9460466

chr1:44687312

ENST00000281419

O43150

944_1006

156.66666666666666

1007.0

Domain

SH3

Hgene

ASAP2

chr2:9460466

chr1:44687312

ENST00000281419

O43150

288_312

156.66666666666666

1007.0

Region

Disordered

Hgene

ASAP2

chr2:9460466

chr1:44687312

ENST00000281419

O43150

701_720

156.66666666666666

1007.0

Region

Disordered

Hgene

ASAP2

chr2:9460466

chr1:44687312

ENST00000281419

O43150

764_916

156.66666666666666

1007.0

Region

Disordered

Hgene

ASAP2

chr2:9460466

chr1:44687312

ENST00000281419

O43150

584_616

156.66666666666666

1007.0

Repeat

Note=ANK 1

Hgene

ASAP2

chr2:9460466

chr1:44687312

ENST00000281419

O43150

620_649

156.66666666666666

1007.0

Repeat

Note=ANK 2

Tgene

ERI3

chr2:9460466

chr1:44687312

ENST00000372257

O43414

146_320

310.3333333333333

338.0

Domain

Note=Exonuclease

- Retained PPIs in in-frame fusion.

Partner

Hgene

Hbp

Tgene

Tbp

ENST

UniProt

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Hgene

Hbp

Tgene

Tbp

ENST

UniProt

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Fusion Transcript Sequence for ASAP2_ERI3

In-frame Fusion Transcript Sequences.

>ASAP2_ERI3_ENST00000281419_ENST00000372257_9460466_44687312 length=1381nt 
 Breakpoint=810nt
CGCCCCTCTCCGCGGGAGGCGTCGGGGCCCGCGGCTGGGTGGCGGGTAGTTCCCGCCGGCTGTGCGCGCCCGCCTCGGGGCTCGCTCTGAGAGGACGCGGCGGCAGCGGACTCGGAGCCCTCGGCGCGCAGGCGGGCGGACCGGCCGAGC
TGCGCGGGGCTGCGCGCCGCCCCTGCTCCGCCGCCAGGCCCCGCGCGGCTCCCGCGCCCGGCGCTCCCCTTTGTCCGCGGGCCGGAGCGGCGGCGGCAGCGGCGGTGTCCGAGCGGCGGTCGGAGCCTGCTGCGGCAGTTGAGGCGGCGG
CGCCCCTGCGGCTGTGCGCCAGCGCCCTCGCGCCGAGGCGATGCCGGACCAGATCTCCGTGTCGGAATTCGTGGCCGAGACCCATGAGGACTACAAGGCGCCCACGGCCTCCAGCTTCACCACCCGCACGGCGCAGTGCCGGAACACTGT
GGCGGCCATCGAGGAGGCTTTGGACGTGGACCGGATGGTTCTTTACAAAATGAAGAAATCCGTGAAAGCAATCAACAGCTCTGGGCTGGCTCACGTGGAAAATGAAGAGCAGTACACCCAGGCTCTGGAGAAGTTTGGCGGCAACTGTGT
ATGCAGAGATGACCCAGATTTAGGAAGTGCGTTCCTGAAGTTCTCAGTGTTTACAAAGGAGTTGACAGCACTTTTCAAAAACCTGATTCAGAATATGAACAACATAATCTCCTTCCCTTTGGACAGTTTGCTGAAGGGGGACCTGAAAGG
AGTGAAAGGGGATCTGAAAAAGCCTTTTGATAAAGCTTGGAAGGACTATGAAACAAAAATACGACTGCAAGAACATTGCCAACATCATGAAGACACTCGCCTATCGAGGCTTCATCTTCAAGCAGACATCGAAGCCGTTCTGATTGGCCG
AGGACAGGATGGGGCAGGACAGGGTAGCTGTTTGGCCCAGCCCAGAATCCTCCTCTCCCTCACCAGAGGGGAAGAGGGAGAGTGGCATAGCTCTGTGTCCAGAGTGTCCCCAGCTGCCCTGTGGGCTCATGCCCTTGGCGTGGGCTTGTG
CCCTTGCAAGGGCTTGGCCACTTGGCCCTTCTGGAGCAGACACTTTGTGCCCCCCATCCCCACCCCTCAATCTCAGCCCAGTATCAGCCCCTCCCATTGCGGGCCTGGGCTAGGGGGACCCAGGCACTCACCGCCTCCTCCCTGGTACAC
AGGCTTCTGTGGGGCCACCAAGCCCCTCCTGTGCCCCCTCCCATCCATAGTGCATGGTGTGTGGTGCCCCCAGGGCTCCAGGACAGATCAGGCCCCACCTTGTGTCTACCCCCATCCCCGCTGTGAACGTGCCACTGAATAAAGTCGGGG
AAACGAGGCACTGGGTGTGTGTGCAAAGCCA

>ASAP2_ERI3_ENST00000315273_ENST00000372257_9460466_44687312 length=1381nt 
 Breakpoint=810nt
CGCCCCTCTCCGCGGGAGGCGTCGGGGCCCGCGGCTGGGTGGCGGGTAGTTCCCGCCGGCTGTGCGCGCCCGCCTCGGGGCTCGCTCTGAGAGGACGCGGCGGCAGCGGACTCGGAGCCCTCGGCGCGCAGGCGGGCGGACCGGCCGAGC
TGCGCGGGGCTGCGCGCCGCCCCTGCTCCGCCGCCAGGCCCCGCGCGGCTCCCGCGCCCGGCGCTCCCCTTTGTCCGCGGGCCGGAGCGGCGGCGGCAGCGGCGGTGTCCGAGCGGCGGTCGGAGCCTGCTGCGGCAGTTGAGGCGGCGG
CGCCCCTGCGGCTGTGCGCCAGCGCCCTCGCGCCGAGGCGATGCCGGACCAGATCTCCGTGTCGGAATTCGTGGCCGAGACCCATGAGGACTACAAGGCGCCCACGGCCTCCAGCTTCACCACCCGCACGGCGCAGTGCCGGAACACTGT
GGCGGCCATCGAGGAGGCTTTGGACGTGGACCGGATGGTTCTTTACAAAATGAAGAAATCCGTGAAAGCAATCAACAGCTCTGGGCTGGCTCACGTGGAAAATGAAGAGCAGTACACCCAGGCTCTGGAGAAGTTTGGCGGCAACTGTGT
ATGCAGAGATGACCCAGATTTAGGAAGTGCGTTCCTGAAGTTCTCAGTGTTTACAAAGGAGTTGACAGCACTTTTCAAAAACCTGATTCAGAATATGAACAACATAATCTCCTTCCCTTTGGACAGTTTGCTGAAGGGGGACCTGAAAGG
AGTGAAAGGGGATCTGAAAAAGCCTTTTGATAAAGCTTGGAAGGACTATGAAACAAAAATACGACTGCAAGAACATTGCCAACATCATGAAGACACTCGCCTATCGAGGCTTCATCTTCAAGCAGACATCGAAGCCGTTCTGATTGGCCG
AGGACAGGATGGGGCAGGACAGGGTAGCTGTTTGGCCCAGCCCAGAATCCTCCTCTCCCTCACCAGAGGGGAAGAGGGAGAGTGGCATAGCTCTGTGTCCAGAGTGTCCCCAGCTGCCCTGTGGGCTCATGCCCTTGGCGTGGGCTTGTG
CCCTTGCAAGGGCTTGGCCACTTGGCCCTTCTGGAGCAGACACTTTGTGCCCCCCATCCCCACCCCTCAATCTCAGCCCAGTATCAGCCCCTCCCATTGCGGGCCTGGGCTAGGGGGACCCAGGCACTCACCGCCTCCTCCCTGGTACAC
AGGCTTCTGTGGGGCCACCAAGCCCCTCCTGTGCCCCCTCCCATCCATAGTGCATGGTGTGTGGTGCCCCCAGGGCTCCAGGACAGATCAGGCCCCACCTTGTGTCTACCCCCATCCCCGCTGTGAACGTGCCACTGAATAAAGTCGGGG
AAACGAGGCACTGGGTGTGTGTGCAAAGCCA

N-Truncated Transcript (5UTR-3CDS) Sequences

C-Truncated Transcript (5CDS-3UTR) Sequences

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Fusion Protein Sequence for ASAP2_ERI3

In-frame Fusion Protein Sequences.

>ASAP2_ERI3_ENST00000281419_ENST00000372257_9460466_44687312 length=635nt
MPDQISVSEFVAETHEDYKAPTASSFTTRTAQCRNTVAAIEEALDVDRMVLYKMKKSVKAINSSGLAHVENEEQYTQALEKFGGNCVCRDDPDLGSAFLKFSVFTKELTALFKNLIQNMNNIISFPLDSLLKGDLKGVKGVNFVVCQLFA
LLAAIWFRTYLHSSKTSSFIRHVVATLLGLYLALFCFGWYALHFLVQSGISYCIMIIIGVENMHNYCFVFALGYLTVCQVTRVYIFDYGQYSADFSGPMMIITQKITSLACEIHDGMFRKDEELTSSQRDLAVRRMPSLLEYLSYNCNFM
GILAGPLCSYKDYITFIEGRSYHITQSGENGKEETQYERTEPSPNTAVVQKLLVCGLSLLFHLTICTTLPVEYNIDEHFQATASWPTKIIYLYISLLAARPKYYFAWTLADAINNAAGFGFRGYDENGAARWDLISNLRIQQIEMSTSFK
MFLDNWNIQTALWLKRVCYERTSFSPTIQTFILSAIWHGVYPGYYLTFLTGVLMTLAARAMRNNFRHYFIEPSQLKLFYDVITWIVTQVAISYTVVPFVLLSIKPSLTFYSSWYYCLHILGILVLLLLPVKKTQRRKNTHENIQLSQSKK
FDEGENSLGQNSFSTTNNVCNQNQEIASRHSSLKQ

>ASAP2_ERI3_ENST00000315273_ENST00000372257_9460466_44687312 length=333nt
MPDQISVSEFVAETHEDYKAPTASSFTTRTAQCRNTVAAIEEALDVDRMVLYKMKKSVKAINSSGLAHVENEEQYTQALEKFGGNCVCRDDPDLGSAFLKFSVFTKELTALFKNLIQNMNNIISFPLDSLLKGDLKGVKGDLKKPFDKAW
KDYETKIRLQEHCQHHEDTRLSRLHLQADIEAVLIGRGQDGAGQGSCLAQPRILLSLTRGEEGEWHSSVSRVSPAALWAHALGVGLCPCKGLATWPFWSRHFVPPIPTPQSQPSISPSHCGPGLGGPRHSPPPPWYTGFCGATKPLLCPL
PSIVHGVWCPQGSRTDQAPPCVYPHPRCERATE

N-Truncated Protein (5UTR-3CDS) Sequences

C-Truncated Protein (5CDS-3UTR) Sequences

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Personalized Fusion Protein Sequence for ASAP2_ERI3

TCGA Kinase/DNA-binding Domain Mutated Fusion Protein Sequences

Num

Gene Group

Domain Loci

Fusion Protein ID

Fusion Gene Name

Partner

Mutated Residue in WT Protein

Seq. Length

Mutated Residue in Fusion Protein

CCLE Kinase/DNA-binding Domain Mutated Fusion Protein Sequences

Num

Gene Group

Domain Loci

Fusion Protein ID

Fusion Gene Name

Partner

Mutated Residue in WT Protein

Seq. Length

Mutated Residue in Fusion Protein

TCGA All Mutated Fusion Protein Sequences

>ASAP2_ERI3_ENST00000281419_ENST00000372257_9460466_44687312_5-gene_p.A110T_635_A110T length=635AA
MPDQISVSEFVAETHEDYKAPTASSFTTRTAQCRNTVAAIEEALDVDRMVLYKMKKSVKAINSSGLAHVENEEQYTQALEKFGGNCVCRDDPDLGSAFLKFSVFTKELTTLFKNLIQNMNNIISFPLDSLLKGDLKGVKGVNFVVCQLFA
LLAAIWFRTYLHSSKTSSFIRHVVATLLGLYLALFCFGWYALHFLVQSGISYCIMIIIGVENMHNYCFVFALGYLTVCQVTRVYIFDYGQYSADFSGPMMIITQKITSLACEIHDGMFRKDEELTSSQRDLAVRRMPSLLEYLSYNCNFM
GILAGPLCSYKDYITFIEGRSYHITQSGENGKEETQYERTEPSPNTAVVQKLLVCGLSLLFHLTICTTLPVEYNIDEHFQATASWPTKIIYLYISLLAARPKYYFAWTLADAINNAAGFGFRGYDENGAARWDLISNLRIQQIEMSTSFK
MFLDNWNIQTALWLKRVCYERTSFSPTIQTFILSAIWHGVYPGYYLTFLTGVLMTLAARAMRNNFRHYFIEPSQLKLFYDVITWIVTQVAISYTVVPFVLLSIKPSLTFYSSWYYCLHILGILVLLLLPVKKTQRRKNTHENIQLSQSKK
FDEGENSLGQNSFSTTNNVCNQNQEIASRHSSLKQ

>ASAP2_ERI3_ENST00000281419_ENST00000372257_9460466_44687312_5-gene_p.R48L_635_R48L length=635AA
MPDQISVSEFVAETHEDYKAPTASSFTTRTAQCRNTVAAIEEALDVDLMVLYKMKKSVKAINSSGLAHVENEEQYTQALEKFGGNCVCRDDPDLGSAFLKFSVFTKELTALFKNLIQNMNNIISFPLDSLLKGDLKGVKGVNFVVCQLFA
LLAAIWFRTYLHSSKTSSFIRHVVATLLGLYLALFCFGWYALHFLVQSGISYCIMIIIGVENMHNYCFVFALGYLTVCQVTRVYIFDYGQYSADFSGPMMIITQKITSLACEIHDGMFRKDEELTSSQRDLAVRRMPSLLEYLSYNCNFM
GILAGPLCSYKDYITFIEGRSYHITQSGENGKEETQYERTEPSPNTAVVQKLLVCGLSLLFHLTICTTLPVEYNIDEHFQATASWPTKIIYLYISLLAARPKYYFAWTLADAINNAAGFGFRGYDENGAARWDLISNLRIQQIEMSTSFK
MFLDNWNIQTALWLKRVCYERTSFSPTIQTFILSAIWHGVYPGYYLTFLTGVLMTLAARAMRNNFRHYFIEPSQLKLFYDVITWIVTQVAISYTVVPFVLLSIKPSLTFYSSWYYCLHILGILVLLLLPVKKTQRRKNTHENIQLSQSKK
FDEGENSLGQNSFSTTNNVCNQNQEIASRHSSLKQ

>ASAP2_ERI3_ENST00000281419_ENST00000372257_9460466_44687312_5-gene_p.G133V_635_G133V length=635AA
MPDQISVSEFVAETHEDYKAPTASSFTTRTAQCRNTVAAIEEALDVDRMVLYKMKKSVKAINSSGLAHVENEEQYTQALEKFGGNCVCRDDPDLGSAFLKFSVFTKELTALFKNLIQNMNNIISFPLDSLLKVDLKGVKGVNFVVCQLFA
LLAAIWFRTYLHSSKTSSFIRHVVATLLGLYLALFCFGWYALHFLVQSGISYCIMIIIGVENMHNYCFVFALGYLTVCQVTRVYIFDYGQYSADFSGPMMIITQKITSLACEIHDGMFRKDEELTSSQRDLAVRRMPSLLEYLSYNCNFM
GILAGPLCSYKDYITFIEGRSYHITQSGENGKEETQYERTEPSPNTAVVQKLLVCGLSLLFHLTICTTLPVEYNIDEHFQATASWPTKIIYLYISLLAARPKYYFAWTLADAINNAAGFGFRGYDENGAARWDLISNLRIQQIEMSTSFK
MFLDNWNIQTALWLKRVCYERTSFSPTIQTFILSAIWHGVYPGYYLTFLTGVLMTLAARAMRNNFRHYFIEPSQLKLFYDVITWIVTQVAISYTVVPFVLLSIKPSLTFYSSWYYCLHILGILVLLLLPVKKTQRRKNTHENIQLSQSKK
FDEGENSLGQNSFSTTNNVCNQNQEIASRHSSLKQ

>ASAP2_ERI3_ENST00000281419_ENST00000372257_9460466_44687312_5-gene_p.F101L_635_F101L length=635AA
MPDQISVSEFVAETHEDYKAPTASSFTTRTAQCRNTVAAIEEALDVDRMVLYKMKKSVKAINSSGLAHVENEEQYTQALEKFGGNCVCRDDPDLGSAFLKLSVFTKELTALFKNLIQNMNNIISFPLDSLLKGDLKGVKGVNFVVCQLFA
LLAAIWFRTYLHSSKTSSFIRHVVATLLGLYLALFCFGWYALHFLVQSGISYCIMIIIGVENMHNYCFVFALGYLTVCQVTRVYIFDYGQYSADFSGPMMIITQKITSLACEIHDGMFRKDEELTSSQRDLAVRRMPSLLEYLSYNCNFM
GILAGPLCSYKDYITFIEGRSYHITQSGENGKEETQYERTEPSPNTAVVQKLLVCGLSLLFHLTICTTLPVEYNIDEHFQATASWPTKIIYLYISLLAARPKYYFAWTLADAINNAAGFGFRGYDENGAARWDLISNLRIQQIEMSTSFK
MFLDNWNIQTALWLKRVCYERTSFSPTIQTFILSAIWHGVYPGYYLTFLTGVLMTLAARAMRNNFRHYFIEPSQLKLFYDVITWIVTQVAISYTVVPFVLLSIKPSLTFYSSWYYCLHILGILVLLLLPVKKTQRRKNTHENIQLSQSKK
FDEGENSLGQNSFSTTNNVCNQNQEIASRHSSLKQ

>ASAP2_ERI3_ENST00000281419_ENST00000372257_9460466_44687312_5-gene_p.G133R_635_G133R length=635AA
MPDQISVSEFVAETHEDYKAPTASSFTTRTAQCRNTVAAIEEALDVDRMVLYKMKKSVKAINSSGLAHVENEEQYTQALEKFGGNCVCRDDPDLGSAFLKFSVFTKELTALFKNLIQNMNNIISFPLDSLLKRDLKGVKGVNFVVCQLFA
LLAAIWFRTYLHSSKTSSFIRHVVATLLGLYLALFCFGWYALHFLVQSGISYCIMIIIGVENMHNYCFVFALGYLTVCQVTRVYIFDYGQYSADFSGPMMIITQKITSLACEIHDGMFRKDEELTSSQRDLAVRRMPSLLEYLSYNCNFM
GILAGPLCSYKDYITFIEGRSYHITQSGENGKEETQYERTEPSPNTAVVQKLLVCGLSLLFHLTICTTLPVEYNIDEHFQATASWPTKIIYLYISLLAARPKYYFAWTLADAINNAAGFGFRGYDENGAARWDLISNLRIQQIEMSTSFK
MFLDNWNIQTALWLKRVCYERTSFSPTIQTFILSAIWHGVYPGYYLTFLTGVLMTLAARAMRNNFRHYFIEPSQLKLFYDVITWIVTQVAISYTVVPFVLLSIKPSLTFYSSWYYCLHILGILVLLLLPVKKTQRRKNTHENIQLSQSKK
FDEGENSLGQNSFSTTNNVCNQNQEIASRHSSLKQ

>ASAP2_ERI3_ENST00000281419_ENST00000372257_9460466_44687312_5-gene_p.D47G_635_D47G length=635AA
MPDQISVSEFVAETHEDYKAPTASSFTTRTAQCRNTVAAIEEALDVGRMVLYKMKKSVKAINSSGLAHVENEEQYTQALEKFGGNCVCRDDPDLGSAFLKFSVFTKELTALFKNLIQNMNNIISFPLDSLLKGDLKGVKGVNFVVCQLFA
LLAAIWFRTYLHSSKTSSFIRHVVATLLGLYLALFCFGWYALHFLVQSGISYCIMIIIGVENMHNYCFVFALGYLTVCQVTRVYIFDYGQYSADFSGPMMIITQKITSLACEIHDGMFRKDEELTSSQRDLAVRRMPSLLEYLSYNCNFM
GILAGPLCSYKDYITFIEGRSYHITQSGENGKEETQYERTEPSPNTAVVQKLLVCGLSLLFHLTICTTLPVEYNIDEHFQATASWPTKIIYLYISLLAARPKYYFAWTLADAINNAAGFGFRGYDENGAARWDLISNLRIQQIEMSTSFK
MFLDNWNIQTALWLKRVCYERTSFSPTIQTFILSAIWHGVYPGYYLTFLTGVLMTLAARAMRNNFRHYFIEPSQLKLFYDVITWIVTQVAISYTVVPFVLLSIKPSLTFYSSWYYCLHILGILVLLLLPVKKTQRRKNTHENIQLSQSKK
FDEGENSLGQNSFSTTNNVCNQNQEIASRHSSLKQ

>ASAP2_ERI3_ENST00000281419_ENST00000372257_9460466_44687312_5-gene_p.I61M_635_I61M length=635AA
MPDQISVSEFVAETHEDYKAPTASSFTTRTAQCRNTVAAIEEALDVDRMVLYKMKKSVKAMNSSGLAHVENEEQYTQALEKFGGNCVCRDDPDLGSAFLKFSVFTKELTALFKNLIQNMNNIISFPLDSLLKGDLKGVKGVNFVVCQLFA
LLAAIWFRTYLHSSKTSSFIRHVVATLLGLYLALFCFGWYALHFLVQSGISYCIMIIIGVENMHNYCFVFALGYLTVCQVTRVYIFDYGQYSADFSGPMMIITQKITSLACEIHDGMFRKDEELTSSQRDLAVRRMPSLLEYLSYNCNFM
GILAGPLCSYKDYITFIEGRSYHITQSGENGKEETQYERTEPSPNTAVVQKLLVCGLSLLFHLTICTTLPVEYNIDEHFQATASWPTKIIYLYISLLAARPKYYFAWTLADAINNAAGFGFRGYDENGAARWDLISNLRIQQIEMSTSFK
MFLDNWNIQTALWLKRVCYERTSFSPTIQTFILSAIWHGVYPGYYLTFLTGVLMTLAARAMRNNFRHYFIEPSQLKLFYDVITWIVTQVAISYTVVPFVLLSIKPSLTFYSSWYYCLHILGILVLLLLPVKKTQRRKNTHENIQLSQSKK
FDEGENSLGQNSFSTTNNVCNQNQEIASRHSSLKQ

>ASAP2_ERI3_ENST00000281419_ENST00000372257_9460466_44687312_5-gene_p.Q117E_635_Q117E length=635AA
MPDQISVSEFVAETHEDYKAPTASSFTTRTAQCRNTVAAIEEALDVDRMVLYKMKKSVKAINSSGLAHVENEEQYTQALEKFGGNCVCRDDPDLGSAFLKFSVFTKELTALFKNLIENMNNIISFPLDSLLKGDLKGVKGVNFVVCQLFA
LLAAIWFRTYLHSSKTSSFIRHVVATLLGLYLALFCFGWYALHFLVQSGISYCIMIIIGVENMHNYCFVFALGYLTVCQVTRVYIFDYGQYSADFSGPMMIITQKITSLACEIHDGMFRKDEELTSSQRDLAVRRMPSLLEYLSYNCNFM
GILAGPLCSYKDYITFIEGRSYHITQSGENGKEETQYERTEPSPNTAVVQKLLVCGLSLLFHLTICTTLPVEYNIDEHFQATASWPTKIIYLYISLLAARPKYYFAWTLADAINNAAGFGFRGYDENGAARWDLISNLRIQQIEMSTSFK
MFLDNWNIQTALWLKRVCYERTSFSPTIQTFILSAIWHGVYPGYYLTFLTGVLMTLAARAMRNNFRHYFIEPSQLKLFYDVITWIVTQVAISYTVVPFVLLSIKPSLTFYSSWYYCLHILGILVLLLLPVKKTQRRKNTHENIQLSQSKK
FDEGENSLGQNSFSTTNNVCNQNQEIASRHSSLKQ

>ASAP2_ERI3_ENST00000281419_ENST00000372257_9460466_44687312_5-gene_p.A23T_635_A23T length=635AA
MPDQISVSEFVAETHEDYKAPTTSSFTTRTAQCRNTVAAIEEALDVDRMVLYKMKKSVKAINSSGLAHVENEEQYTQALEKFGGNCVCRDDPDLGSAFLKFSVFTKELTALFKNLIQNMNNIISFPLDSLLKGDLKGVKGVNFVVCQLFA
LLAAIWFRTYLHSSKTSSFIRHVVATLLGLYLALFCFGWYALHFLVQSGISYCIMIIIGVENMHNYCFVFALGYLTVCQVTRVYIFDYGQYSADFSGPMMIITQKITSLACEIHDGMFRKDEELTSSQRDLAVRRMPSLLEYLSYNCNFM
GILAGPLCSYKDYITFIEGRSYHITQSGENGKEETQYERTEPSPNTAVVQKLLVCGLSLLFHLTICTTLPVEYNIDEHFQATASWPTKIIYLYISLLAARPKYYFAWTLADAINNAAGFGFRGYDENGAARWDLISNLRIQQIEMSTSFK
MFLDNWNIQTALWLKRVCYERTSFSPTIQTFILSAIWHGVYPGYYLTFLTGVLMTLAARAMRNNFRHYFIEPSQLKLFYDVITWIVTQVAISYTVVPFVLLSIKPSLTFYSSWYYCLHILGILVLLLLPVKKTQRRKNTHENIQLSQSKK
FDEGENSLGQNSFSTTNNVCNQNQEIASRHSSLKQ

>ASAP2_ERI3_ENST00000281419_ENST00000372257_9460466_44687312_5-gene_p.P126H_635_P126H length=635AA
MPDQISVSEFVAETHEDYKAPTASSFTTRTAQCRNTVAAIEEALDVDRMVLYKMKKSVKAINSSGLAHVENEEQYTQALEKFGGNCVCRDDPDLGSAFLKFSVFTKELTALFKNLIQNMNNIISFHLDSLLKGDLKGVKGVNFVVCQLFA
LLAAIWFRTYLHSSKTSSFIRHVVATLLGLYLALFCFGWYALHFLVQSGISYCIMIIIGVENMHNYCFVFALGYLTVCQVTRVYIFDYGQYSADFSGPMMIITQKITSLACEIHDGMFRKDEELTSSQRDLAVRRMPSLLEYLSYNCNFM
GILAGPLCSYKDYITFIEGRSYHITQSGENGKEETQYERTEPSPNTAVVQKLLVCGLSLLFHLTICTTLPVEYNIDEHFQATASWPTKIIYLYISLLAARPKYYFAWTLADAINNAAGFGFRGYDENGAARWDLISNLRIQQIEMSTSFK
MFLDNWNIQTALWLKRVCYERTSFSPTIQTFILSAIWHGVYPGYYLTFLTGVLMTLAARAMRNNFRHYFIEPSQLKLFYDVITWIVTQVAISYTVVPFVLLSIKPSLTFYSSWYYCLHILGILVLLLLPVKKTQRRKNTHENIQLSQSKK
FDEGENSLGQNSFSTTNNVCNQNQEIASRHSSLKQ

>ASAP2_ERI3_ENST00000281419_ENST00000372257_9460466_44687312_5-gene_p.P126T_635_P126T length=635AA
MPDQISVSEFVAETHEDYKAPTASSFTTRTAQCRNTVAAIEEALDVDRMVLYKMKKSVKAINSSGLAHVENEEQYTQALEKFGGNCVCRDDPDLGSAFLKFSVFTKELTALFKNLIQNMNNIISFTLDSLLKGDLKGVKGVNFVVCQLFA
LLAAIWFRTYLHSSKTSSFIRHVVATLLGLYLALFCFGWYALHFLVQSGISYCIMIIIGVENMHNYCFVFALGYLTVCQVTRVYIFDYGQYSADFSGPMMIITQKITSLACEIHDGMFRKDEELTSSQRDLAVRRMPSLLEYLSYNCNFM
GILAGPLCSYKDYITFIEGRSYHITQSGENGKEETQYERTEPSPNTAVVQKLLVCGLSLLFHLTICTTLPVEYNIDEHFQATASWPTKIIYLYISLLAARPKYYFAWTLADAINNAAGFGFRGYDENGAARWDLISNLRIQQIEMSTSFK
MFLDNWNIQTALWLKRVCYERTSFSPTIQTFILSAIWHGVYPGYYLTFLTGVLMTLAARAMRNNFRHYFIEPSQLKLFYDVITWIVTQVAISYTVVPFVLLSIKPSLTFYSSWYYCLHILGILVLLLLPVKKTQRRKNTHENIQLSQSKK
FDEGENSLGQNSFSTTNNVCNQNQEIASRHSSLKQ

>ASAP2_ERI3_ENST00000281419_ENST00000372257_9460466_44687312_5-gene_p.R29S_635_R29S length=635AA
MPDQISVSEFVAETHEDYKAPTASSFTTSTAQCRNTVAAIEEALDVDRMVLYKMKKSVKAINSSGLAHVENEEQYTQALEKFGGNCVCRDDPDLGSAFLKFSVFTKELTALFKNLIQNMNNIISFPLDSLLKGDLKGVKGVNFVVCQLFA
LLAAIWFRTYLHSSKTSSFIRHVVATLLGLYLALFCFGWYALHFLVQSGISYCIMIIIGVENMHNYCFVFALGYLTVCQVTRVYIFDYGQYSADFSGPMMIITQKITSLACEIHDGMFRKDEELTSSQRDLAVRRMPSLLEYLSYNCNFM
GILAGPLCSYKDYITFIEGRSYHITQSGENGKEETQYERTEPSPNTAVVQKLLVCGLSLLFHLTICTTLPVEYNIDEHFQATASWPTKIIYLYISLLAARPKYYFAWTLADAINNAAGFGFRGYDENGAARWDLISNLRIQQIEMSTSFK
MFLDNWNIQTALWLKRVCYERTSFSPTIQTFILSAIWHGVYPGYYLTFLTGVLMTLAARAMRNNFRHYFIEPSQLKLFYDVITWIVTQVAISYTVVPFVLLSIKPSLTFYSSWYYCLHILGILVLLLLPVKKTQRRKNTHENIQLSQSKK
FDEGENSLGQNSFSTTNNVCNQNQEIASRHSSLKQ

>ASAP2_ERI3_ENST00000281419_ENST00000372257_9460466_44687312_5-gene_p.A97V_635_A97V length=635AA
MPDQISVSEFVAETHEDYKAPTASSFTTRTAQCRNTVAAIEEALDVDRMVLYKMKKSVKAINSSGLAHVENEEQYTQALEKFGGNCVCRDDPDLGSVFLKFSVFTKELTALFKNLIQNMNNIISFPLDSLLKGDLKGVKGVNFVVCQLFA
LLAAIWFRTYLHSSKTSSFIRHVVATLLGLYLALFCFGWYALHFLVQSGISYCIMIIIGVENMHNYCFVFALGYLTVCQVTRVYIFDYGQYSADFSGPMMIITQKITSLACEIHDGMFRKDEELTSSQRDLAVRRMPSLLEYLSYNCNFM
GILAGPLCSYKDYITFIEGRSYHITQSGENGKEETQYERTEPSPNTAVVQKLLVCGLSLLFHLTICTTLPVEYNIDEHFQATASWPTKIIYLYISLLAARPKYYFAWTLADAINNAAGFGFRGYDENGAARWDLISNLRIQQIEMSTSFK
MFLDNWNIQTALWLKRVCYERTSFSPTIQTFILSAIWHGVYPGYYLTFLTGVLMTLAARAMRNNFRHYFIEPSQLKLFYDVITWIVTQVAISYTVVPFVLLSIKPSLTFYSSWYYCLHILGILVLLLLPVKKTQRRKNTHENIQLSQSKK
FDEGENSLGQNSFSTTNNVCNQNQEIASRHSSLKQ

>ASAP2_ERI3_ENST00000281419_ENST00000372257_9460466_44687312_5-gene_p.E41V_635_E41V length=635AA
MPDQISVSEFVAETHEDYKAPTASSFTTRTAQCRNTVAAIVEALDVDRMVLYKMKKSVKAINSSGLAHVENEEQYTQALEKFGGNCVCRDDPDLGSAFLKFSVFTKELTALFKNLIQNMNNIISFPLDSLLKGDLKGVKGVNFVVCQLFA
LLAAIWFRTYLHSSKTSSFIRHVVATLLGLYLALFCFGWYALHFLVQSGISYCIMIIIGVENMHNYCFVFALGYLTVCQVTRVYIFDYGQYSADFSGPMMIITQKITSLACEIHDGMFRKDEELTSSQRDLAVRRMPSLLEYLSYNCNFM
GILAGPLCSYKDYITFIEGRSYHITQSGENGKEETQYERTEPSPNTAVVQKLLVCGLSLLFHLTICTTLPVEYNIDEHFQATASWPTKIIYLYISLLAARPKYYFAWTLADAINNAAGFGFRGYDENGAARWDLISNLRIQQIEMSTSFK
MFLDNWNIQTALWLKRVCYERTSFSPTIQTFILSAIWHGVYPGYYLTFLTGVLMTLAARAMRNNFRHYFIEPSQLKLFYDVITWIVTQVAISYTVVPFVLLSIKPSLTFYSSWYYCLHILGILVLLLLPVKKTQRRKNTHENIQLSQSKK
FDEGENSLGQNSFSTTNNVCNQNQEIASRHSSLKQ

>ASAP2_ERI3_ENST00000281419_ENST00000372257_9460466_44687312_5-gene_p.L79M_635_L79M length=635AA
MPDQISVSEFVAETHEDYKAPTASSFTTRTAQCRNTVAAIEEALDVDRMVLYKMKKSVKAINSSGLAHVENEEQYTQAMEKFGGNCVCRDDPDLGSAFLKFSVFTKELTALFKNLIQNMNNIISFPLDSLLKGDLKGVKGVNFVVCQLFA
LLAAIWFRTYLHSSKTSSFIRHVVATLLGLYLALFCFGWYALHFLVQSGISYCIMIIIGVENMHNYCFVFALGYLTVCQVTRVYIFDYGQYSADFSGPMMIITQKITSLACEIHDGMFRKDEELTSSQRDLAVRRMPSLLEYLSYNCNFM
GILAGPLCSYKDYITFIEGRSYHITQSGENGKEETQYERTEPSPNTAVVQKLLVCGLSLLFHLTICTTLPVEYNIDEHFQATASWPTKIIYLYISLLAARPKYYFAWTLADAINNAAGFGFRGYDENGAARWDLISNLRIQQIEMSTSFK
MFLDNWNIQTALWLKRVCYERTSFSPTIQTFILSAIWHGVYPGYYLTFLTGVLMTLAARAMRNNFRHYFIEPSQLKLFYDVITWIVTQVAISYTVVPFVLLSIKPSLTFYSSWYYCLHILGILVLLLLPVKKTQRRKNTHENIQLSQSKK
FDEGENSLGQNSFSTTNNVCNQNQEIASRHSSLKQ

>ASAP2_ERI3_ENST00000315273_ENST00000372257_9460466_44687312_5-gene_p.A110T_333_A110T length=333AA
MPDQISVSEFVAETHEDYKAPTASSFTTRTAQCRNTVAAIEEALDVDRMVLYKMKKSVKAINSSGLAHVENEEQYTQALEKFGGNCVCRDDPDLGSAFLKFSVFTKELTTLFKNLIQNMNNIISFPLDSLLKGDLKGVKGDLKKPFDKAW
KDYETKIRLQEHCQHHEDTRLSRLHLQADIEAVLIGRGQDGAGQGSCLAQPRILLSLTRGEEGEWHSSVSRVSPAALWAHALGVGLCPCKGLATWPFWSRHFVPPIPTPQSQPSISPSHCGPGLGGPRHSPPPPWYTGFCGATKPLLCPL
PSIVHGVWCPQGSRTDQAPPCVYPHPRCERATE

>ASAP2_ERI3_ENST00000315273_ENST00000372257_9460466_44687312_5-gene_p.R48L_333_R48L length=333AA
MPDQISVSEFVAETHEDYKAPTASSFTTRTAQCRNTVAAIEEALDVDLMVLYKMKKSVKAINSSGLAHVENEEQYTQALEKFGGNCVCRDDPDLGSAFLKFSVFTKELTALFKNLIQNMNNIISFPLDSLLKGDLKGVKGDLKKPFDKAW
KDYETKIRLQEHCQHHEDTRLSRLHLQADIEAVLIGRGQDGAGQGSCLAQPRILLSLTRGEEGEWHSSVSRVSPAALWAHALGVGLCPCKGLATWPFWSRHFVPPIPTPQSQPSISPSHCGPGLGGPRHSPPPPWYTGFCGATKPLLCPL
PSIVHGVWCPQGSRTDQAPPCVYPHPRCERATE

>ASAP2_ERI3_ENST00000315273_ENST00000372257_9460466_44687312_5-gene_p.G133V_333_G133V length=333AA
MPDQISVSEFVAETHEDYKAPTASSFTTRTAQCRNTVAAIEEALDVDRMVLYKMKKSVKAINSSGLAHVENEEQYTQALEKFGGNCVCRDDPDLGSAFLKFSVFTKELTALFKNLIQNMNNIISFPLDSLLKVDLKGVKGDLKKPFDKAW
KDYETKIRLQEHCQHHEDTRLSRLHLQADIEAVLIGRGQDGAGQGSCLAQPRILLSLTRGEEGEWHSSVSRVSPAALWAHALGVGLCPCKGLATWPFWSRHFVPPIPTPQSQPSISPSHCGPGLGGPRHSPPPPWYTGFCGATKPLLCPL
PSIVHGVWCPQGSRTDQAPPCVYPHPRCERATE

>ASAP2_ERI3_ENST00000315273_ENST00000372257_9460466_44687312_5-gene_p.F101L_333_F101L length=333AA
MPDQISVSEFVAETHEDYKAPTASSFTTRTAQCRNTVAAIEEALDVDRMVLYKMKKSVKAINSSGLAHVENEEQYTQALEKFGGNCVCRDDPDLGSAFLKLSVFTKELTALFKNLIQNMNNIISFPLDSLLKGDLKGVKGDLKKPFDKAW
KDYETKIRLQEHCQHHEDTRLSRLHLQADIEAVLIGRGQDGAGQGSCLAQPRILLSLTRGEEGEWHSSVSRVSPAALWAHALGVGLCPCKGLATWPFWSRHFVPPIPTPQSQPSISPSHCGPGLGGPRHSPPPPWYTGFCGATKPLLCPL
PSIVHGVWCPQGSRTDQAPPCVYPHPRCERATE

>ASAP2_ERI3_ENST00000315273_ENST00000372257_9460466_44687312_5-gene_p.G133R_333_G133R length=333AA
MPDQISVSEFVAETHEDYKAPTASSFTTRTAQCRNTVAAIEEALDVDRMVLYKMKKSVKAINSSGLAHVENEEQYTQALEKFGGNCVCRDDPDLGSAFLKFSVFTKELTALFKNLIQNMNNIISFPLDSLLKRDLKGVKGDLKKPFDKAW
KDYETKIRLQEHCQHHEDTRLSRLHLQADIEAVLIGRGQDGAGQGSCLAQPRILLSLTRGEEGEWHSSVSRVSPAALWAHALGVGLCPCKGLATWPFWSRHFVPPIPTPQSQPSISPSHCGPGLGGPRHSPPPPWYTGFCGATKPLLCPL
PSIVHGVWCPQGSRTDQAPPCVYPHPRCERATE

>ASAP2_ERI3_ENST00000315273_ENST00000372257_9460466_44687312_5-gene_p.D47G_333_D47G length=333AA
MPDQISVSEFVAETHEDYKAPTASSFTTRTAQCRNTVAAIEEALDVGRMVLYKMKKSVKAINSSGLAHVENEEQYTQALEKFGGNCVCRDDPDLGSAFLKFSVFTKELTALFKNLIQNMNNIISFPLDSLLKGDLKGVKGDLKKPFDKAW
KDYETKIRLQEHCQHHEDTRLSRLHLQADIEAVLIGRGQDGAGQGSCLAQPRILLSLTRGEEGEWHSSVSRVSPAALWAHALGVGLCPCKGLATWPFWSRHFVPPIPTPQSQPSISPSHCGPGLGGPRHSPPPPWYTGFCGATKPLLCPL
PSIVHGVWCPQGSRTDQAPPCVYPHPRCERATE

>ASAP2_ERI3_ENST00000315273_ENST00000372257_9460466_44687312_5-gene_p.I61M_333_I61M length=333AA
MPDQISVSEFVAETHEDYKAPTASSFTTRTAQCRNTVAAIEEALDVDRMVLYKMKKSVKAMNSSGLAHVENEEQYTQALEKFGGNCVCRDDPDLGSAFLKFSVFTKELTALFKNLIQNMNNIISFPLDSLLKGDLKGVKGDLKKPFDKAW
KDYETKIRLQEHCQHHEDTRLSRLHLQADIEAVLIGRGQDGAGQGSCLAQPRILLSLTRGEEGEWHSSVSRVSPAALWAHALGVGLCPCKGLATWPFWSRHFVPPIPTPQSQPSISPSHCGPGLGGPRHSPPPPWYTGFCGATKPLLCPL
PSIVHGVWCPQGSRTDQAPPCVYPHPRCERATE

>ASAP2_ERI3_ENST00000315273_ENST00000372257_9460466_44687312_5-gene_p.Q117E_333_Q117E length=333AA
MPDQISVSEFVAETHEDYKAPTASSFTTRTAQCRNTVAAIEEALDVDRMVLYKMKKSVKAINSSGLAHVENEEQYTQALEKFGGNCVCRDDPDLGSAFLKFSVFTKELTALFKNLIENMNNIISFPLDSLLKGDLKGVKGDLKKPFDKAW
KDYETKIRLQEHCQHHEDTRLSRLHLQADIEAVLIGRGQDGAGQGSCLAQPRILLSLTRGEEGEWHSSVSRVSPAALWAHALGVGLCPCKGLATWPFWSRHFVPPIPTPQSQPSISPSHCGPGLGGPRHSPPPPWYTGFCGATKPLLCPL
PSIVHGVWCPQGSRTDQAPPCVYPHPRCERATE

>ASAP2_ERI3_ENST00000315273_ENST00000372257_9460466_44687312_5-gene_p.F146S_333_F146S length=333AA
MPDQISVSEFVAETHEDYKAPTASSFTTRTAQCRNTVAAIEEALDVDRMVLYKMKKSVKAINSSGLAHVENEEQYTQALEKFGGNCVCRDDPDLGSAFLKFSVFTKELTALFKNLIQNMNNIISFPLDSLLKGDLKGVKGDLKKPSDKAW
KDYETKIRLQEHCQHHEDTRLSRLHLQADIEAVLIGRGQDGAGQGSCLAQPRILLSLTRGEEGEWHSSVSRVSPAALWAHALGVGLCPCKGLATWPFWSRHFVPPIPTPQSQPSISPSHCGPGLGGPRHSPPPPWYTGFCGATKPLLCPL
PSIVHGVWCPQGSRTDQAPPCVYPHPRCERATE

>ASAP2_ERI3_ENST00000315273_ENST00000372257_9460466_44687312_5-gene_p.A23T_333_A23T length=333AA
MPDQISVSEFVAETHEDYKAPTTSSFTTRTAQCRNTVAAIEEALDVDRMVLYKMKKSVKAINSSGLAHVENEEQYTQALEKFGGNCVCRDDPDLGSAFLKFSVFTKELTALFKNLIQNMNNIISFPLDSLLKGDLKGVKGDLKKPFDKAW
KDYETKIRLQEHCQHHEDTRLSRLHLQADIEAVLIGRGQDGAGQGSCLAQPRILLSLTRGEEGEWHSSVSRVSPAALWAHALGVGLCPCKGLATWPFWSRHFVPPIPTPQSQPSISPSHCGPGLGGPRHSPPPPWYTGFCGATKPLLCPL
PSIVHGVWCPQGSRTDQAPPCVYPHPRCERATE

>ASAP2_ERI3_ENST00000315273_ENST00000372257_9460466_44687312_5-gene_p.P126H_333_P126H length=333AA
MPDQISVSEFVAETHEDYKAPTASSFTTRTAQCRNTVAAIEEALDVDRMVLYKMKKSVKAINSSGLAHVENEEQYTQALEKFGGNCVCRDDPDLGSAFLKFSVFTKELTALFKNLIQNMNNIISFHLDSLLKGDLKGVKGDLKKPFDKAW
KDYETKIRLQEHCQHHEDTRLSRLHLQADIEAVLIGRGQDGAGQGSCLAQPRILLSLTRGEEGEWHSSVSRVSPAALWAHALGVGLCPCKGLATWPFWSRHFVPPIPTPQSQPSISPSHCGPGLGGPRHSPPPPWYTGFCGATKPLLCPL
PSIVHGVWCPQGSRTDQAPPCVYPHPRCERATE

>ASAP2_ERI3_ENST00000315273_ENST00000372257_9460466_44687312_5-gene_p.P126T_333_P126T length=333AA
MPDQISVSEFVAETHEDYKAPTASSFTTRTAQCRNTVAAIEEALDVDRMVLYKMKKSVKAINSSGLAHVENEEQYTQALEKFGGNCVCRDDPDLGSAFLKFSVFTKELTALFKNLIQNMNNIISFTLDSLLKGDLKGVKGDLKKPFDKAW
KDYETKIRLQEHCQHHEDTRLSRLHLQADIEAVLIGRGQDGAGQGSCLAQPRILLSLTRGEEGEWHSSVSRVSPAALWAHALGVGLCPCKGLATWPFWSRHFVPPIPTPQSQPSISPSHCGPGLGGPRHSPPPPWYTGFCGATKPLLCPL
PSIVHGVWCPQGSRTDQAPPCVYPHPRCERATE

>ASAP2_ERI3_ENST00000315273_ENST00000372257_9460466_44687312_5-gene_p.R29S_333_R29S length=333AA
MPDQISVSEFVAETHEDYKAPTASSFTTSTAQCRNTVAAIEEALDVDRMVLYKMKKSVKAINSSGLAHVENEEQYTQALEKFGGNCVCRDDPDLGSAFLKFSVFTKELTALFKNLIQNMNNIISFPLDSLLKGDLKGVKGDLKKPFDKAW
KDYETKIRLQEHCQHHEDTRLSRLHLQADIEAVLIGRGQDGAGQGSCLAQPRILLSLTRGEEGEWHSSVSRVSPAALWAHALGVGLCPCKGLATWPFWSRHFVPPIPTPQSQPSISPSHCGPGLGGPRHSPPPPWYTGFCGATKPLLCPL
PSIVHGVWCPQGSRTDQAPPCVYPHPRCERATE

>ASAP2_ERI3_ENST00000315273_ENST00000372257_9460466_44687312_5-gene_p.A97V_333_A97V length=333AA
MPDQISVSEFVAETHEDYKAPTASSFTTRTAQCRNTVAAIEEALDVDRMVLYKMKKSVKAINSSGLAHVENEEQYTQALEKFGGNCVCRDDPDLGSVFLKFSVFTKELTALFKNLIQNMNNIISFPLDSLLKGDLKGVKGDLKKPFDKAW
KDYETKIRLQEHCQHHEDTRLSRLHLQADIEAVLIGRGQDGAGQGSCLAQPRILLSLTRGEEGEWHSSVSRVSPAALWAHALGVGLCPCKGLATWPFWSRHFVPPIPTPQSQPSISPSHCGPGLGGPRHSPPPPWYTGFCGATKPLLCPL
PSIVHGVWCPQGSRTDQAPPCVYPHPRCERATE

>ASAP2_ERI3_ENST00000315273_ENST00000372257_9460466_44687312_5-gene_p.E41V_333_E41V length=333AA
MPDQISVSEFVAETHEDYKAPTASSFTTRTAQCRNTVAAIVEALDVDRMVLYKMKKSVKAINSSGLAHVENEEQYTQALEKFGGNCVCRDDPDLGSAFLKFSVFTKELTALFKNLIQNMNNIISFPLDSLLKGDLKGVKGDLKKPFDKAW
KDYETKIRLQEHCQHHEDTRLSRLHLQADIEAVLIGRGQDGAGQGSCLAQPRILLSLTRGEEGEWHSSVSRVSPAALWAHALGVGLCPCKGLATWPFWSRHFVPPIPTPQSQPSISPSHCGPGLGGPRHSPPPPWYTGFCGATKPLLCPL
PSIVHGVWCPQGSRTDQAPPCVYPHPRCERATE

>ASAP2_ERI3_ENST00000315273_ENST00000372257_9460466_44687312_5-gene_p.L79M_333_L79M length=333AA
MPDQISVSEFVAETHEDYKAPTASSFTTRTAQCRNTVAAIEEALDVDRMVLYKMKKSVKAINSSGLAHVENEEQYTQAMEKFGGNCVCRDDPDLGSAFLKFSVFTKELTALFKNLIQNMNNIISFPLDSLLKGDLKGVKGDLKKPFDKAW
KDYETKIRLQEHCQHHEDTRLSRLHLQADIEAVLIGRGQDGAGQGSCLAQPRILLSLTRGEEGEWHSSVSRVSPAALWAHALGVGLCPCKGLATWPFWSRHFVPPIPTPQSQPSISPSHCGPGLGGPRHSPPPPWYTGFCGATKPLLCPL
PSIVHGVWCPQGSRTDQAPPCVYPHPRCERATE

Fusion Protein ID	Sample ID	Mutated Partner	AAchange in WT	Seq. Length	AAchange in Fusion
ENST00000281419_ENST00000372257_9460466_44687312	TCGA-2W-A8YY-01A	5-gene	p.A110T	635	A110T
ENST00000281419_ENST00000372257_9460466_44687312	TCGA-33-AASD-01A	5-gene	p.R48L	635	R48L
ENST00000281419_ENST00000372257_9460466_44687312	TCGA-78-7146-01A	5-gene	p.G133V	635	G133V
ENST00000281419_ENST00000372257_9460466_44687312	TCGA-A5-A2K5-01A	5-gene	p.F101L	635	F101L
ENST00000281419_ENST00000372257_9460466_44687312	TCGA-AA-3492-01A	5-gene	p.G133R	635	G133R
ENST00000281419_ENST00000372257_9460466_44687312	TCGA-AP-A056-01A	5-gene	p.D47G	635	D47G
ENST00000281419_ENST00000372257_9460466_44687312	TCGA-BT-A20R-01A	5-gene	p.I61M	635	I61M
ENST00000281419_ENST00000372257_9460466_44687312	TCGA-EB-A57M-01A	5-gene	p.Q117E	635	Q117E
ENST00000281419_ENST00000372257_9460466_44687312	TCGA-F7-A624-01A	5-gene	p.A23T	635	A23T
ENST00000281419_ENST00000372257_9460466_44687312	TCGA-FS-A1ZC-06A	5-gene	p.P126H	635	P126H
ENST00000281419_ENST00000372257_9460466_44687312	TCGA-GN-A26D-06A	5-gene	p.P126T	635	P126T
ENST00000281419_ENST00000372257_9460466_44687312	TCGA-HE-7128-01A	5-gene	p.R29S	635	R29S
ENST00000281419_ENST00000372257_9460466_44687312	TCGA-HU-A4H4-01A	5-gene	p.A97V	635	A97V
ENST00000281419_ENST00000372257_9460466_44687312	TCGA-K7-A5RG-01A	5-gene	p.E41V	635	E41V
ENST00000281419_ENST00000372257_9460466_44687312	TCGA-ZJ-AAXU-01A	5-gene	p.L79M	635	L79M
ENST00000315273_ENST00000372257_9460466_44687312	TCGA-2W-A8YY-01A	5-gene	p.A110T	333	A110T
ENST00000315273_ENST00000372257_9460466_44687312	TCGA-33-AASD-01A	5-gene	p.R48L	333	R48L
ENST00000315273_ENST00000372257_9460466_44687312	TCGA-78-7146-01A	5-gene	p.G133V	333	G133V
ENST00000315273_ENST00000372257_9460466_44687312	TCGA-A5-A2K5-01A	5-gene	p.F101L	333	F101L
ENST00000315273_ENST00000372257_9460466_44687312	TCGA-AA-3492-01A	5-gene	p.G133R	333	G133R
ENST00000315273_ENST00000372257_9460466_44687312	TCGA-AP-A056-01A	5-gene	p.D47G	333	D47G
ENST00000315273_ENST00000372257_9460466_44687312	TCGA-BT-A20R-01A	5-gene	p.I61M	333	I61M
ENST00000315273_ENST00000372257_9460466_44687312	TCGA-EB-A57M-01A	5-gene	p.Q117E	333	Q117E
ENST00000315273_ENST00000372257_9460466_44687312	TCGA-EO-A22R-01A	5-gene	p.F146S	333	F146S
ENST00000315273_ENST00000372257_9460466_44687312	TCGA-F7-A624-01A	5-gene	p.A23T	333	A23T
ENST00000315273_ENST00000372257_9460466_44687312	TCGA-FS-A1ZC-06A	5-gene	p.P126H	333	P126H
ENST00000315273_ENST00000372257_9460466_44687312	TCGA-GN-A26D-06A	5-gene	p.P126T	333	P126T
ENST00000315273_ENST00000372257_9460466_44687312	TCGA-HE-7128-01A	5-gene	p.R29S	333	R29S
ENST00000315273_ENST00000372257_9460466_44687312	TCGA-HU-A4H4-01A	5-gene	p.A97V	333	A97V
ENST00000315273_ENST00000372257_9460466_44687312	TCGA-K7-A5RG-01A	5-gene	p.E41V	333	E41V
ENST00000315273_ENST00000372257_9460466_44687312	TCGA-ZJ-AAXU-01A	5-gene	p.L79M	333	L79M

CCLE All Mutated Fusion Protein Sequences

Fusion Protein ID

Sample ID

Mutated Partner

AAchange in WT

Seq. Length

AAchange in Fusion

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Fusion Gene Exprssed Samples for ASAP2_ERI3

RNA-seq based fusion gene expressed samples.

Source	Study	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB		UCEC	TCGA-B5-A0K3	ASAP2	chr2	9460466	+	ERI3	chr1	44687312	-

DNA-seq based fusion gene expressed samples.

Source

Study

Disease

Sample

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

SV type

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Related Drugs for ASAP2_ERI3

PubMed Abstract Search With ['A-B' AND 'drug'], ['A::B' AND 'drug']
* For more details on the Studied, Reported, Approved Drugs targeting this fusion gene, Go to FusionPub.

PMID

Fusion Gene Name

Drug

Study Title

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status