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	Fusion Gene Summary
	Fusion Gene Breakpoints
	Tumorigenic MoA (Mechanism of Action) Scenarios of Fusion Geness
	Fusion Genomic Features
	Fusion Gene ORF Annotations
	Fusion Protein Retained/Non-Retained Functional Features
	Fusion Transcript Sequences
	Fusion Protein Sequences
	Personalized Fusion Protein Sequences
	Fusion Gene Expressed Samples
	Related Drugs

Fusion gene:CERS5_SAMD11 (FusionGDB2 ID:HG91012TG148398)

Fusion Gene Summary for CERS5_SAMD11

Fusion gene summary

Fusion gene information	Fusion gene name: CERS5_SAMD11
	Fusion gene ID: hg91012tg148398
		Hgene	Tgene
	Gene symbol	CERS5	SAMD11
	Gene ID	91012	148398
	Gene name	ceramide synthase 5	sterile alpha motif domain containing 11
	Synonyms	LASS5\|Trh4	MRS
	Cytomap	12q13.12	1p36.33
	Type of gene	protein-coding	protein-coding
	Description	ceramide synthase 5LAG1 homolog, ceramide synthase 5LAG1 longevity assurance homolog 5TRAM homolog 4sphingoid base N-palmitoyltransferase CERS5sphingosine N-acyltransferase CERS5	sterile alpha motif domain-containing protein 11SAM domain-containing protein 11
	Modification date	20240403	20240305
	UniProtAcc	.	.
	Ensembl transtripts involved in fusion gene	ENST00000317551, ENST00000422340, ENST00000547852,
Fusion gene scores	* DoF score	* DoF score (Degree of Frequency) = # partners X # break points X # disease types 11 X 12 X 9=1188	* DoF score (Degree of Frequency) = # partners X # break points X # disease types 1 X 6 X 4=24
	# samples	110	5
	** MAII score	** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score10) log2(110/118810)=-0.111031312388744 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score10) log2(5/2410)=1.05889368905357 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0
Context	PubMed: CERS5 [Title/Abstract] AND SAMD11 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	CERS5(50560883)-SAMD11(874419), # samples:1

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Fusion Gene Breakpoints for CERS5_SAMD11

RNA-seq based exon junction arranged fusion gene breakpoints from 8 resources (TCGA, CCLE, cBioPortal, GenBank, ChimerDB, ChimerKB, ChildHoodFusions, and GTEx). For the expressed sample information, go to Fusion Gene Sample section.

Hgene	Hchr	Hbp	Tgene	Tchr	Tbp
CERS5	chr12	50560883	SAMD11	chr1	50560883
CERS5	chr12	50560883	SAMD11	chr1	874420
CERS5	chr12	50560884	SAMD11	chr1	874420
CERS5	chr12	50167101	SAMD11	chr1	939040

DNA-seq based exon junction arranged fusion gene breakpoints from dbVar. For the expressed sample information, go to Fusion Gene Sample section.

Hgene

Hchr

Hbp

Tgene

Tchr

Tbp

SV type

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Tumorigenic MoA (Mechanism of Action) Scenarios of Fusion Genes for CERS5_SAMD11

To generate these tumorigenic scenario annotations, we implemented a deduction-first, retrieval-later computational framework. The pipeline first applies rule-guided reasoning across ten core mechanistic categories (M1–M10) derived from fusion gene biology to infer candidate mechanisms, tumorigenic scenarios, targeting points, and targeting backgrounds. To ensure empirical accountability, a governed Python workflow retrieves literature candidates via NCBI E-utilities and Europe PMC using tiered searches. Using JSON Schema-constrained LLM evidence judges (GPT-5.6 Luna and Terra), retrieved articles are evaluated for specificity and confidence without de novo PMID generation. This produces two distinct versions: a strict version restricted to high- or medium-confidence fusion-specific evidence, and an extended version incorporating broader gene-, pathway-, and contextual evidence.

* We have 10 tumorigenic mechanism categories of fusion genes as shown below.

Constitutively Active Kinases, Catalytic Domain Dysregulation, & Transmembrane Ligand Fusions	Aberrant Chimeric Transcription Factor / Fusion Transcription Factor Activity	Epigenetic Reprogramming / Histone Modifier Dysregulation	Chromatin Remodeling Dysregulation	Condensate-Driven Transcriptional Rewiring / LLP	Promoter / Enhancer Hijacking	Dominant-Negative Antagonism	Cell Cycle / Checkpoint Bypass / RNA Processing Dysregulation	Subcellular Mislocalization / Spatial Dysregulation	Nuclear Body / Sub-organellar Architecture Disruption & Differentiation Blockade

* Strict version: Restricted to high- or medium-confidence fusion-specific evidence.

Fusion Gene Name	Mechanism Category	Mechanism PubMed	Tumorigenic Scenarios	Tumorigenic Scenario PubMed	Targeting Points	Targeting PubMed	Mechanism Background	Mechanism Background PubMed
CERS5-SAMD11	Promoter / Enhancer Hijacking M6		Promoter swap alters sterile alpha motif domain-containing 11 expression, modifying protein-protein scaffolding complexes.		Standard chemotherapy regimens		Solid tumors

* Extended version: Includes all strict-level fusion evidence plus broader gene-, pathway-, and low-confidence contextual evidence.

Fusion Gene Name	Mechanism Category	Mechanism PubMed	Tumorigenic Scenarios	Tumorigenic Scenario PubMed	Targeting Points	Targeting PubMed	Mechanism Background	Mechanism Background PubMed
CERS5-SAMD11	Promoter / Enhancer Hijacking M6		Promoter swap alters sterile alpha motif domain-containing 11 expression, modifying protein-protein scaffolding complexes.	Evidence level: Limited indirect gene evidence; Confidence: Low; PMID: 39362437; Title: Investigating the mechanism of METTL16-dependent m6A modification regulating the SAMD11 protein signaling pathway to inhibit thyroid cancer phenotypes.	Standard chemotherapy regimens		Solid tumors	Evidence level: Indirect gene evidence; Confidence: Medium; PMID: 28912426; Title: Deconvolution of DNA methylation identifies differentially methylated gene regions on 1p36 across breast cancer subtypes.; PMID: 39362437; Title: Investigating the mechanism of METTL16-dependent m6A modification regulating the SAMD11 protein signaling pathway to inhibit thyroid cancer phenotypes.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	CERS5	GO:0046513	ceramide biosynthetic process	16951403\|29632068

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Fusion Genomic Features for CERS5_SAMD11

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence) of In-frame fusion genes. FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
CERS5	chr12	50560883	-	SAMD11	chr1	874419	+	2.15e-09	1.00e+00

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence) of 5UTR-3CSD fusion genes (N-truncated cases).

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
CERS5	chr12	50560883	-	SAMD11	chr1	874419	+	2.15e-09	1.00e+00

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence) of 5CDS-3UTR fusion genes (C-truncated cases).

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of six genomic regulatory feature tracks across a ±5 kb window centered on the fusion breakpoints. We input the breakpoint sequences into AlphaGenome and obtained predicted genome tracks at single-base-pair resolution for each modality by running a single forward pass over the reference sequence. Specifically, for each breakpoint, AlphaGenome processed and returned predicted track data across diverse modalities, which were then averaged across all tracks within each output type and visualized across the ±5 kb window. The left panel shows the 5'-gene breakpoint ±5 kb area, and the right panel shows the 3'-gene breakpoint area, with tracks grouped by category: chromatin accessibility (DNase-seq, ATAC-seq), active transcription (RNA-seq, CAGE), and chromatin binding (ChIP-Histone, ChIP-TF).

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Fusion Gene ORF Annotations for CERS5_SAMD11

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5UTR-3CDS	ENST00000422340	ENST00000342066	CERS5	chr12	50560883	-	SAMD11	chr1	874419	+
5UTR-3CDS	ENST00000547852	ENST00000342066	CERS5	chr12	50560883	-	SAMD11	chr1	874419	+
Frame-shift	ENST00000317551	ENST00000342066	CERS5	chr12	50560883	-	SAMD11	chr1	874419	+

ORFfinder Result Based On The Fusion Transcript Sequences of the In-frame Fusion Genes.

Henst

Tenst

Hgene

Hchr

Hbp

Tgene

Tchr

Tbp

Seq length
(transcript)

Seq length
(peptide)

ORFfinder Result Based On The Fusion Transcript Sequences of the 5UTR-3CDS Fusion Genes for N-Truncated Protein Search.

Henst	Tenst	Hgene	Hchr	Hbp	Tgene	Tchr	Tbp	Seq length (transcript)	Seq length (peptide)
ENST00000422340	ENST00000342066	CERS5	chr12	50560883	SAMD11	chr1	874419	0	137
ENST00000547852	ENST00000342066	CERS5	chr12	50560883	SAMD11	chr1	874419	0	137

ORFfinder Result Based On The Fusion Transcript Sequences of the 5CDS-3UTR Fusion Genes for C-Truncated Protein Search.

Henst

Tenst

Hgene

Hchr

Hbp

Tgene

Tchr

Tbp

Seq length
(transcript)

Seq length
(peptide)

DeepORF Prediction of The Coding Potential Based on The Fusion Transcript Sequence of In-frame Fusion Genes. DeepORF is a Coding Potential Classifier Based on Convolutional Neural Network by Comparing the Real Ribo-seq Data. If the No-coding Score < 0.5 and Coding Score > 0.5, Then The In-frame Fusion Transcript is Predicted as Being Likely Translated.

Henst

Tenst

Hgene

Hchr

Hbp

Tgene

Tchr

Tbp

No-coding score

Coding score

DeepORF Prediction of The Coding Potential Based on The Fusion Transcript Sequence of 5UTR-3CDS Fusion Genes (Potential N-Truncated Proteins).

Henst	Tenst	Hgene	Hchr	Hbp	Tgene	Tchr	Tbp	No-coding score	Coding score
ENST00000422340	ENST00000342066	CERS5	chr12	50560883	SAMD11	chr1	874419	0.00e+00	2.04e-03
ENST00000547852	ENST00000342066	CERS5	chr12	50560883	SAMD11	chr1	874419	0.00e+00	2.04e-03

DeepORF Prediction of The Coding Potential Based on The Fusion Transcript Sequence of 5CDS-3UTR Fusion Genes (Potential C-Truncated Proteins).

Henst

Tenst

Hgene

Hchr

Hbp

Tgene

Tchr

Tbp

No-coding score

Coding score

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Fusion Protein Retained/Non-Retained Functional Features for CERS5_SAMD11

Protein Level Annotation from FGviewer
* Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at download page. Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features (visualization across fusion protein length).

No matching images found for ${hg}_${tg}.

- In-frame and retained protein feature among the 13 regional features (texts).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- Retained PPIs in in-frame fusion.

Partner

Hgene

Hbp

Tgene

Tbp

ENST

UniProt

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Hgene

Hbp

Tgene

Tbp

ENST

UniProt

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Fusion Transcript Sequence for CERS5_SAMD11

In-frame Fusion Transcript Sequences.

N-Truncated Transcript (5UTR-3CDS) Sequences

>CERS5_SAMD11_ENST00000422340_ENST00000342066_50560883_874419 length=2038nt 
 Breakpoint=0nt
GTGACCTGTTGGGCAAGAGGCTGGGCCGCTCCCCCCGTATCAGCAGCGACTGCTTTTCAGAGAAGAGGGCACGAAGCGAATCGCCTCAAGAGGCGCTGCTGCTGCCGCGGGAGCTGGGGCCCAGCATGGCCCCGGAGGACCATTACCGCC
GGCTTGTGTCAGCACTGAGCGAGGCCAGCACCTTTGAGGACCCTCAGCGCCTCTACCACCTGGGCCTCCCCAGCCACGGTGAGGACCCACCCTGGCATGATCCCCCTCATCACCTCCCCAGCCACGATCTCCTGAGGGTCCGGCAGGAGG
TGGCGGCTGCAGCTCTGAGGGGCCCCAGTGGCCTGGAAGCCCACCTGCCCTCCTCCACGGCAGGTCAGCGTCGGAAGCAGGGCCTGGCTCAGCACCGGGAGGGCGCCGCCCCAGCTGCCGCCCCGTCCTTCTCGGAGAGGGAGCTGCCTC
AGCCGCCCCCCTTGCTGTCGCCGCAGAATGCCCCTCACGTCGCCCTGGGCCCCCATCTCAGGCCCCCCTTCCTGGGGGTGCCCTCGGCTCTGTGCCAGACCCCAGGCTACGGCTTCCTGCCCCCCGCGCAGGCGGAGATGTTCGCCTGGC
AGCAGGAGCTCCTGCGGAAGCAGAACCTGGCCCGGCTGGAGCTGCCCGCCGACCTCCTGCGGCAGAAGGAGCTGGAGAGCGCGCGCCCACAGCTGCTGGCGCCCGAGACCGCCCTGCGCCCCAACGACGGCGCCGAGGAGCTGCAGCGGC
GCGGGGCCCTGCTGGTGCTGAACCACGGCGCGGCGCCACTGCTGGCCCTGCCCCCCCAGGGGCCCCCGGGCTCCGGACCCCCCACCCCGTCCCGGGACTCTGCCCGGCGAGCCCCCCGGAAGGGGGGTCCCGGCCCTGCCTCAGCGCGGC
CCAGCGAGTCCAAGGAGATGACGGGGGCTAGGCTCTGGGCACAAGATGGCTCGGAAGACGAGCCCCCCAAAGACTCGGACGGAGAGGACCCCGAGACGGCAGCTGTTGGGTGCAGGGGGCCCACTCCGGGCCAAGCTCCAGCTGGAGGGG
CCGGCGCCGAGGGGAAGGGGCTTTTCCCAGGGTCCACACTGCCCCTGGGCTTCCCTTATGCCGTCAGCCCCTACTTCCACACAGGCGCGGTAGGGGGACTCTCCATGGATGGGGAGGAGGCCCCAGCCCCTGAGGACGTCACCAAGTGGA
CCGTGGATGACGTCTGCAGCTTCGTGGGGGGCCTGTCTGGCTGTGGAGAGTACACTCGGGTCTTCAGGGAGCAGGGGATCGACGGGGAGACCCTGCCACTGCTGACGGAGGAGCACCTGCTGACCAACATGGGGCTGAAGCTGGGGCCCG
CCCTCAAGATCCGGGCCCAGGTGGCCAGGCGCCTGGGCCGAGTTTTCTACGTGGCCAGCTTCCCCGTGGCTCTGCCACTGCAGCCACCAACCCTGCGGGCCCCGGAGCGAGAACTCGGCACAGGAGAGCAGCCCTTGTCCCCCACGACGG
CCACGTCCCCCTATGGAGGGGGCCACGCCCTTGCCGGTCAAACTTCACCCAAGCAGGAGAATGGGACCTTGGCTCTACTTCCAGGGGCCCCCGACCCTTCCCAGCCTCTGTGTTGAGGTTGCCGGGGGTAGGGGTGGGGCCACACAAATC
TCCAGGAGCCACCACTCAACACAATGGCCCTGCCTCCCACCGCTTTATTTCTTTCGGTTTCGGATGCAAAACAAAAAATTTTAAAAGAAAATGTGACTTCAAAGGAAAGGAACAAATTTTCAAAGACTTGGGGGAGTGAAGGCAGAGCCT
GGTGCAGATGGACGAGGTCTGCAGACGGAGGGCAGAGGTGGTGGAAGGGGCCAGGGGCCTGCAGGCCTCCCCCTGGAACTGGGACTGGTCTCGGTCTGCTGACGTCAGGGTCAGCTCCCCCGCGGAGCTGACTTCAGCAGCCCACAGCTG
TGGGGCTTCAGCAGCCACACCAGCCCAGCCCAGCCCAGCTCTCGATACGTTTGGTCTTTCATGCTGAAAAATAAATAATAAAGCCTGT

>CERS5_SAMD11_ENST00000547852_ENST00000342066_50560883_874419 length=2038nt 
 Breakpoint=0nt
GTGACCTGTTGGGCAAGAGGCTGGGCCGCTCCCCCCGTATCAGCAGCGACTGCTTTTCAGAGAAGAGGGCACGAAGCGAATCGCCTCAAGAGGCGCTGCTGCTGCCGCGGGAGCTGGGGCCCAGCATGGCCCCGGAGGACCATTACCGCC
GGCTTGTGTCAGCACTGAGCGAGGCCAGCACCTTTGAGGACCCTCAGCGCCTCTACCACCTGGGCCTCCCCAGCCACGGTGAGGACCCACCCTGGCATGATCCCCCTCATCACCTCCCCAGCCACGATCTCCTGAGGGTCCGGCAGGAGG
TGGCGGCTGCAGCTCTGAGGGGCCCCAGTGGCCTGGAAGCCCACCTGCCCTCCTCCACGGCAGGTCAGCGTCGGAAGCAGGGCCTGGCTCAGCACCGGGAGGGCGCCGCCCCAGCTGCCGCCCCGTCCTTCTCGGAGAGGGAGCTGCCTC
AGCCGCCCCCCTTGCTGTCGCCGCAGAATGCCCCTCACGTCGCCCTGGGCCCCCATCTCAGGCCCCCCTTCCTGGGGGTGCCCTCGGCTCTGTGCCAGACCCCAGGCTACGGCTTCCTGCCCCCCGCGCAGGCGGAGATGTTCGCCTGGC
AGCAGGAGCTCCTGCGGAAGCAGAACCTGGCCCGGCTGGAGCTGCCCGCCGACCTCCTGCGGCAGAAGGAGCTGGAGAGCGCGCGCCCACAGCTGCTGGCGCCCGAGACCGCCCTGCGCCCCAACGACGGCGCCGAGGAGCTGCAGCGGC
GCGGGGCCCTGCTGGTGCTGAACCACGGCGCGGCGCCACTGCTGGCCCTGCCCCCCCAGGGGCCCCCGGGCTCCGGACCCCCCACCCCGTCCCGGGACTCTGCCCGGCGAGCCCCCCGGAAGGGGGGTCCCGGCCCTGCCTCAGCGCGGC
CCAGCGAGTCCAAGGAGATGACGGGGGCTAGGCTCTGGGCACAAGATGGCTCGGAAGACGAGCCCCCCAAAGACTCGGACGGAGAGGACCCCGAGACGGCAGCTGTTGGGTGCAGGGGGCCCACTCCGGGCCAAGCTCCAGCTGGAGGGG
CCGGCGCCGAGGGGAAGGGGCTTTTCCCAGGGTCCACACTGCCCCTGGGCTTCCCTTATGCCGTCAGCCCCTACTTCCACACAGGCGCGGTAGGGGGACTCTCCATGGATGGGGAGGAGGCCCCAGCCCCTGAGGACGTCACCAAGTGGA
CCGTGGATGACGTCTGCAGCTTCGTGGGGGGCCTGTCTGGCTGTGGAGAGTACACTCGGGTCTTCAGGGAGCAGGGGATCGACGGGGAGACCCTGCCACTGCTGACGGAGGAGCACCTGCTGACCAACATGGGGCTGAAGCTGGGGCCCG
CCCTCAAGATCCGGGCCCAGGTGGCCAGGCGCCTGGGCCGAGTTTTCTACGTGGCCAGCTTCCCCGTGGCTCTGCCACTGCAGCCACCAACCCTGCGGGCCCCGGAGCGAGAACTCGGCACAGGAGAGCAGCCCTTGTCCCCCACGACGG
CCACGTCCCCCTATGGAGGGGGCCACGCCCTTGCCGGTCAAACTTCACCCAAGCAGGAGAATGGGACCTTGGCTCTACTTCCAGGGGCCCCCGACCCTTCCCAGCCTCTGTGTTGAGGTTGCCGGGGGTAGGGGTGGGGCCACACAAATC
TCCAGGAGCCACCACTCAACACAATGGCCCTGCCTCCCACCGCTTTATTTCTTTCGGTTTCGGATGCAAAACAAAAAATTTTAAAAGAAAATGTGACTTCAAAGGAAAGGAACAAATTTTCAAAGACTTGGGGGAGTGAAGGCAGAGCCT
GGTGCAGATGGACGAGGTCTGCAGACGGAGGGCAGAGGTGGTGGAAGGGGCCAGGGGCCTGCAGGCCTCCCCCTGGAACTGGGACTGGTCTCGGTCTGCTGACGTCAGGGTCAGCTCCCCCGCGGAGCTGACTTCAGCAGCCCACAGCTG
TGGGGCTTCAGCAGCCACACCAGCCCAGCCCAGCCCAGCTCTCGATACGTTTGGTCTTTCATGCTGAAAAATAAATAATAAAGCCTGT

C-Truncated Transcript (5CDS-3UTR) Sequences

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Fusion Protein Sequence for CERS5_SAMD11

In-frame Fusion Protein Sequences.

N-Truncated Protein (5UTR-3CDS) Sequences

>CERS5_SAMD11_ENST00000422340_ENST00000342066_50560883_874419 length=137nt
MEAMSENKMVPSEFSTGPVEKAAKPLPFKDPNFVHSGHGGAVAGKKNRTWKNLKQILASERALPWQLNDPNYFSIDAPPSFKPAKKYSDVSGLLANYTDPQSKLRFSTIEEFSYIRRLPSDVVTGYLALRKATSIVP

>CERS5_SAMD11_ENST00000547852_ENST00000342066_50560883_874419 length=137nt
MEAMSENKMVPSEFSTGPVEKAAKPLPFKDPNFVHSGHGGAVAGKKNRTWKNLKQILASERALPWQLNDPNYFSIDAPPSFKPAKKYSDVSGLLANYTDPQSKLRFSTIEEFSYIRRLPSDVVTGYLALRKATSIVP

C-Truncated Protein (5CDS-3UTR) Sequences

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Personalized Fusion Protein Sequence for CERS5_SAMD11

TCGA Kinase/DNA-binding Domain Mutated Fusion Protein Sequences

Num

Gene Group

Domain Loci

Fusion Protein ID

Fusion Gene Name

Partner

Mutated Residue in WT Protein

Seq. Length

Mutated Residue in Fusion Protein

CCLE Kinase/DNA-binding Domain Mutated Fusion Protein Sequences

Num

Gene Group

Domain Loci

Fusion Protein ID

Fusion Gene Name

Partner

Mutated Residue in WT Protein

Seq. Length

Mutated Residue in Fusion Protein

TCGA All Mutated Fusion Protein Sequences

Fusion Protein ID

Sample ID

Mutated Partner

AAchange in WT

Seq. Length

AAchange in Fusion

CCLE All Mutated Fusion Protein Sequences

Fusion Protein ID

Sample ID

Mutated Partner

AAchange in WT

Seq. Length

AAchange in Fusion

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Fusion Gene Exprssed Samples for CERS5_SAMD11

RNA-seq based fusion gene expressed samples.

Source	Study	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB		BRCA	TCGA-E2-A1LL-01A	CERS5	chr12	50560883	-	SAMD11	chr1	50560883	+
TCGAfusionPortal		BRCA	TCGA-E2-A1LL-01A	CERS5	chr12	50560883	-	SAMD11	chr1	874420	+
WashU		BRCA	TCGA-E2-A1LL-01A	CERS5	chr12	50560884	-	SAMD11	chr1	874420	+
cBioPortal	BRCA_TCGA_PAN_CAN_ATLAS_2018	BRCA	TCGA-E2-A1LL-01	CERS5	chr12	50167101		SAMD11	chr1	939040

DNA-seq based fusion gene expressed samples.

Source

Study

Disease

Sample

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

SV type

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Related Drugs for CERS5_SAMD11

PubMed Abstract Search With ['A-B' AND 'drug'], ['A::B' AND 'drug']
* For more details on the Studied, Reported, Approved Drugs targeting this fusion gene, Go to FusionPub.

PMID

Fusion Gene Name

Drug

Study Title

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status