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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene Breakpoints

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Tumorigenic MoA (Mechanism of Action) Scenarios of Fusion Geness

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Fusion Genomic Features

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Fusion Gene ORF Annotations

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Fusion Protein Retained/Non-Retained Functional Features

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Fusion Transcript Sequences

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Fusion Protein Sequences

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Personalized Fusion Protein Sequences

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Fusion Gene Expressed Samples

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Related Drugs

Fusion gene:RABEP1_RNF167 (FusionGDB2 ID:HG9135TG26001)

Fusion Gene Summary for RABEP1_RNF167

check button Fusion gene summary
Fusion gene informationFusion gene name: RABEP1_RNF167
Fusion gene ID: hg9135tg26001
HgeneTgene
Gene symbol

RABEP1

RNF167

Gene ID

9135

26001

Gene namerabaptin, RAB GTPase binding effector protein 1ring finger protein 167
SynonymsRAB5EP|RABPT55730408C10Rik|LP2254|RING105
Cytomap

17p13.2

17p13.2

Type of geneprotein-codingprotein-coding
Descriptionrab GTPase-binding effector protein 1neurocrescinrabaptin-4rabaptin-5rabaptin-5alpharenal carcinoma antigen NY-REN-17E3 ubiquitin-protein ligase RNF167RING-type E3 ubiquitin transferase RNF167
Modification date2024040720240305
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000570487, ENST00000262477, 
ENST00000341923, ENST00000408982, 
ENST00000537505, ENST00000546142, 
Fusion gene scores* DoF score* DoF score (Degree of Frequency) = # partners X # break points X # disease types
20 X 17 X 13=4420		* DoF score (Degree of Frequency) = # partners X # break points X # disease types
2 X 9 X 3=54
# samples 6010
** MAII score** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)
log2(60/4420*10)=-2.88101196378291
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)
log2(10/54*10)=0.888968687611256
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: RABEP1 [Title/Abstract] AND RNF167 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointRABEP1(5235447)-RNF167(4843781), # samples:1


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Fusion Gene Breakpoints for RABEP1_RNF167


check button RNA-seq based exon junction arranged fusion gene breakpoints from 8 resources (TCGA, CCLE, cBioPortal, GenBank, ChimerDB, ChimerKB, ChildHoodFusions, and GTEx). For the expressed sample information, go to Fusion Gene Sample section.
HgeneHchrHbpTgeneTchrTbp
RABEP1chr175235447RNF167chr175235447
RABEP1chr175235447RNF167chr174843782
RABEP1chr175332152RNF167chr174940487


check button DNA-seq based exon junction arranged fusion gene breakpoints from dbVar. For the expressed sample information, go to Fusion Gene Sample section.
HgeneHchrHbpTgeneTchrTbpSV type


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Tumorigenic MoA (Mechanism of Action) Scenarios of Fusion Genes for RABEP1_RNF167


check button To generate these tumorigenic scenario annotations, we implemented a deduction-first, retrieval-later computational framework. The pipeline first applies rule-guided reasoning across ten core mechanistic categories (M1–M10) derived from fusion gene biology to infer candidate mechanisms, tumorigenic scenarios, targeting points, and targeting backgrounds. To ensure empirical accountability, a governed Python workflow retrieves literature candidates via NCBI E-utilities and Europe PMC using tiered searches. Using JSON Schema-constrained LLM evidence judges (GPT-5.6 Luna and Terra), retrieved articles are evaluated for specificity and confidence without de novo PMID generation. This produces two distinct versions: a strict version restricted to high- or medium-confidence fusion-specific evidence, and an extended version incorporating broader gene-, pathway-, and contextual evidence.
* We have 10 tumorigenic mechanism categories of fusion genes as shown below.
Constitutively Active Kinases, Catalytic Domain Dysregulation, & Transmembrane Ligand FusionsAberrant Chimeric Transcription Factor / Fusion Transcription Factor ActivityEpigenetic Reprogramming / Histone Modifier DysregulationChromatin Remodeling DysregulationCondensate-Driven Transcriptional Rewiring / LLPPromoter / Enhancer HijackingDominant-Negative AntagonismCell Cycle / Checkpoint Bypass / RNA Processing DysregulationSubcellular Mislocalization / Spatial DysregulationNuclear Body / Sub-organellar Architecture Disruption & Differentiation Blockade

* Strict version: Restricted to high- or medium-confidence fusion-specific evidence.
Fusion Gene NameMechanism CategoryMechanism PubMedTumorigenic ScenariosTumorigenic Scenario PubMedTargeting PointsTargeting PubMedMechanism BackgroundMechanism Background PubMed

* Extended version: Includes all strict-level fusion evidence plus broader gene-, pathway-, and low-confidence contextual evidence.
Fusion Gene NameMechanism CategoryMechanism PubMedTumorigenic ScenariosTumorigenic Scenario PubMedTargeting PointsTargeting PubMedMechanism BackgroundMechanism Background PubMed

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneRNF167

GO:0000209

protein polyubiquitination

16314844

TgeneRNF167

GO:0006511

ubiquitin-dependent protein catabolic process

27808481|33594058

TgeneRNF167

GO:0032418

lysosome localization

32409562

TgeneRNF167

GO:0032418

lysosome localization

27808481

TgeneRNF167

GO:0035519

protein K29-linked ubiquitination

33594058

TgeneRNF167

GO:0051966

regulation of synaptic transmission, glutamatergic

23129617

TgeneRNF167

GO:0070534

protein K63-linked ubiquitination

35114100

TgeneRNF167

GO:1904262

negative regulation of TORC1 signaling

35114100

TgeneRNF167

GO:1904263

positive regulation of TORC1 signaling

33594058

TgeneRNF167

GO:1990253

cellular response to leucine starvation

35114100


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Fusion Genomic Features for RABEP1_RNF167


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence) of In-frame fusion genes. FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
RABEP1chr175235447+RNF167chr174843781+1.33e-039.99e-01


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence) of 5UTR-3CSD fusion genes (N-truncated cases).
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence) of 5CDS-3UTR fusion genes (C-truncated cases).
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of six genomic regulatory feature tracks across a ±5 kb window centered on the fusion breakpoints. We input the breakpoint sequences into AlphaGenome and obtained predicted genome tracks at single-base-pair resolution for each modality by running a single forward pass over the reference sequence. Specifically, for each breakpoint, AlphaGenome processed and returned predicted track data across diverse modalities, which were then averaged across all tracks within each output type and visualized across the ±5 kb window. The left panel shows the 5'-gene breakpoint ±5 kb area, and the right panel shows the 3'-gene breakpoint area, with tracks grouped by category: chromatin accessibility (DNase-seq, ATAC-seq), active transcription (RNA-seq, CAGE), and chromatin binding (ChIP-Histone, ChIP-TF).
genomic feature

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Fusion Gene ORF Annotations for RABEP1_RNF167

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-5UTRENST00000570487ENST00000262482RABEP1chr17

5235447

+RNF167chr17

4843781

+
3UTR-5UTRENST00000570487ENST00000571816RABEP1chr17

5235447

+RNF167chr17

4843781

+
3UTR-5UTRENST00000570487ENST00000572430RABEP1chr17

5235447

+RNF167chr17

4843781

+
3UTR-5UTRENST00000570487ENST00000575111RABEP1chr17

5235447

+RNF167chr17

4843781

+
3UTR-5UTRENST00000570487ENST00000576229RABEP1chr17

5235447

+RNF167chr17

4843781

+
5CDS-5UTRENST00000262477ENST00000262482RABEP1chr17

5235447

+RNF167chr17

4843781

+
5CDS-5UTRENST00000262477ENST00000571816RABEP1chr17

5235447

+RNF167chr17

4843781

+
5CDS-5UTRENST00000262477ENST00000572430RABEP1chr17

5235447

+RNF167chr17

4843781

+
5CDS-5UTRENST00000262477ENST00000575111RABEP1chr17

5235447

+RNF167chr17

4843781

+
5CDS-5UTRENST00000262477ENST00000576229RABEP1chr17

5235447

+RNF167chr17

4843781

+
5CDS-5UTRENST00000341923ENST00000262482RABEP1chr17

5235447

+RNF167chr17

4843781

+
5CDS-5UTRENST00000341923ENST00000571816RABEP1chr17

5235447

+RNF167chr17

4843781

+
5CDS-5UTRENST00000341923ENST00000572430RABEP1chr17

5235447

+RNF167chr17

4843781

+
5CDS-5UTRENST00000341923ENST00000575111RABEP1chr17

5235447

+RNF167chr17

4843781

+
5CDS-5UTRENST00000341923ENST00000576229RABEP1chr17

5235447

+RNF167chr17

4843781

+
5CDS-5UTRENST00000408982ENST00000262482RABEP1chr17

5235447

+RNF167chr17

4843781

+
5CDS-5UTRENST00000408982ENST00000571816RABEP1chr17

5235447

+RNF167chr17

4843781

+
5CDS-5UTRENST00000408982ENST00000572430RABEP1chr17

5235447

+RNF167chr17

4843781

+
5CDS-5UTRENST00000408982ENST00000575111RABEP1chr17

5235447

+RNF167chr17

4843781

+
5CDS-5UTRENST00000408982ENST00000576229RABEP1chr17

5235447

+RNF167chr17

4843781

+
5CDS-5UTRENST00000537505ENST00000262482RABEP1chr17

5235447

+RNF167chr17

4843781

+
5CDS-5UTRENST00000537505ENST00000571816RABEP1chr17

5235447

+RNF167chr17

4843781

+
5CDS-5UTRENST00000537505ENST00000572430RABEP1chr17

5235447

+RNF167chr17

4843781

+
5CDS-5UTRENST00000537505ENST00000575111RABEP1chr17

5235447

+RNF167chr17

4843781

+
5CDS-5UTRENST00000537505ENST00000576229RABEP1chr17

5235447

+RNF167chr17

4843781

+
5CDS-5UTRENST00000546142ENST00000262482RABEP1chr17

5235447

+RNF167chr17

4843781

+
5CDS-5UTRENST00000546142ENST00000571816RABEP1chr17

5235447

+RNF167chr17

4843781

+
5CDS-5UTRENST00000546142ENST00000572430RABEP1chr17

5235447

+RNF167chr17

4843781

+
5CDS-5UTRENST00000546142ENST00000575111RABEP1chr17

5235447

+RNF167chr17

4843781

+
5CDS-5UTRENST00000546142ENST00000576229RABEP1chr17

5235447

+RNF167chr17

4843781

+

check buttonORFfinder Result Based On The Fusion Transcript Sequences of the In-frame Fusion Genes.
HenstTenstHgeneHchrHbpTgeneTchrTbpSeq length
(transcript)		Seq length
(peptide)

check buttonORFfinder Result Based On The Fusion Transcript Sequences of the 5UTR-3CDS Fusion Genes for N-Truncated Protein Search.
HenstTenstHgeneHchrHbpTgeneTchrTbpSeq length
(transcript)		Seq length
(peptide)

check buttonORFfinder Result Based On The Fusion Transcript Sequences of the 5CDS-3UTR Fusion Genes for C-Truncated Protein Search.
HenstTenstHgeneHchrHbpTgeneTchrTbpSeq length
(transcript)		Seq length
(peptide)

check buttonDeepORF Prediction of The Coding Potential Based on The Fusion Transcript Sequence of In-frame Fusion Genes. DeepORF is a Coding Potential Classifier Based on Convolutional Neural Network by Comparing the Real Ribo-seq Data. If the No-coding Score < 0.5 and Coding Score > 0.5, Then The In-frame Fusion Transcript is Predicted as Being Likely Translated.
HenstTenstHgeneHchrHbpTgeneTchrTbpNo-coding scoreCoding score

check buttonDeepORF Prediction of The Coding Potential Based on The Fusion Transcript Sequence of 5UTR-3CDS Fusion Genes (Potential N-Truncated Proteins).
HenstTenstHgeneHchrHbpTgeneTchrTbpNo-coding scoreCoding score

check buttonDeepORF Prediction of The Coding Potential Based on The Fusion Transcript Sequence of 5CDS-3UTR Fusion Genes (Potential C-Truncated Proteins).
HenstTenstHgeneHchrHbpTgeneTchrTbpNo-coding scoreCoding score

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Fusion Protein Retained/Non-Retained Functional Features for RABEP1_RNF167

check buttonProtein Level Annotation from FGviewer
* Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at download page. Minus value of BPloci means that the break pointn is located before the CDS.
fgviewer annotation
- In-frame and retained protein feature among the 13 regional features (visualization across fusion protein length).
No matching images found for ${hg}_${tg}.

- In-frame and retained protein feature among the 13 regional features (texts).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


check button - Retained PPIs in in-frame fusion.
PartnerHgeneHbpTgeneTbpENSTUniProtStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerHgeneHbpTgeneTbpENSTUniProtStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Fusion Transcript Sequence for RABEP1_RNF167

check button In-frame Fusion Transcript Sequences.

check button N-Truncated Transcript (5UTR-3CDS) Sequences

check button C-Truncated Transcript (5CDS-3UTR) Sequences

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Fusion Protein Sequence for RABEP1_RNF167

check button In-frame Fusion Protein Sequences.

check button N-Truncated Protein (5UTR-3CDS) Sequences

check button C-Truncated Protein (5CDS-3UTR) Sequences

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Personalized Fusion Protein Sequence for RABEP1_RNF167


check button TCGA Kinase/DNA-binding Domain Mutated Fusion Protein Sequences
NumGene GroupDomain LociFusion Protein IDFusion Gene NamePartnerMutated Residue in WT ProteinSeq. LengthMutated Residue in Fusion Protein

check button CCLE Kinase/DNA-binding Domain Mutated Fusion Protein Sequences

NumGene GroupDomain LociFusion Protein IDFusion Gene NamePartnerMutated Residue in WT ProteinSeq. LengthMutated Residue in Fusion Protein

check button TCGA All Mutated Fusion Protein Sequences


Fusion Protein IDSample IDMutated PartnerAAchange in WTSeq. LengthAAchange in Fusion

check button CCLE All Mutated Fusion Protein Sequences


Fusion Protein IDSample IDMutated PartnerAAchange in WTSeq. LengthAAchange in Fusion

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Fusion Gene Exprssed Samples for RABEP1_RNF167


check buttonRNA-seq based fusion gene expressed samples.
SourceStudyDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDBHNSCTCGA-UF-A71A-01ARABEP1

chr17

5235447-RNF167

chr17

0

+
ChimerDBHNSCTCGA-UF-A71A-01ARABEP1

chr17

5235447+RNF167

chr17

5235447

+
ChimerDBHNSCTCGA-UF-A71A-06ARABEP1

chr17

5235447-RNF167

chr17

0

+
ChimerDBHNSCTCGA-UF-A71ARABEP1

chr17

5235447+RNF167

chr17

5235447

+
WashUHNSCTCGA-UF-A71A-01ARABEP1

chr17

5235447+RNF167

chr17

4843782

+
cBioPortalHNSC_TCGA_PAN_CAN_ATLAS_2018HNSCTCGA-UF-A71A-01RABEP1

chr17

5332152RNF167

chr17

4940487


check buttonDNA-seq based fusion gene expressed samples.
SourceStudyDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrandSV type


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Related Drugs for RABEP1_RNF167


check button PubMed Abstract Search With ['A-B' AND 'drug'], ['A::B' AND 'drug']
* For more details on the Studied, Reported, Approved Drugs targeting this fusion gene, Go to FusionPub.
PMIDFusion Gene NameDrugStudy Title

check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status