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	Fusion Gene Summary
	Fusion Gene Breakpoints
	Tumorigenic MoA (Mechanism of Action) Scenarios of Fusion Geness
	Fusion Genomic Features
	Fusion Gene ORF Annotations
	Fusion Protein Retained/Non-Retained Functional Features
	Fusion Transcript Sequences
	Fusion Protein Sequences
	Personalized Fusion Protein Sequences
	Fusion Gene Expressed Samples
	Related Drugs

Fusion gene:DNER_TRIP12 (FusionGDB2 ID:HG92737TG9320)

Fusion Gene Summary for DNER_TRIP12

Fusion gene summary

Fusion gene information	Fusion gene name: DNER_TRIP12
	Fusion gene ID: hg92737tg9320
		Hgene	Tgene
	Gene symbol	DNER	TRIP12
	Gene ID	92737	9320
	Gene name	delta/notch like EGF repeat containing	thyroid hormone receptor interactor 12
	Synonyms	UNQ26\|bet	MRD49\|TRIP-12\|TRIPC\|ULF
	Cytomap	2q36.3	2q36.3
	Type of gene	protein-coding	protein-coding
	Description	delta and Notch-like epidermal growth factor-related receptorH_NH0150O02.1WUGSC:H_NH0150O02.1delta-notch-like EGF repeat-containing transmembrane	E3 ubiquitin-protein ligase TRIP12E3 ubiquitin-protein ligase for ArfHECT-type E3 ubiquitin transferase TRIP12TR-interacting protein 12probable E3 ubiquitin-protein ligase TRIP12thyroid receptor interacting protein 12
	Modification date	20240305	20240407
	UniProtAcc	.	.
	Ensembl transtripts involved in fusion gene	ENST00000341772, ENST00000482831,	ENST00000482831, ENST00000341772,
Fusion gene scores	* DoF score	* DoF score (Degree of Frequency) = # partners X # break points X # disease types 5 X 10 X 3=150	* DoF score (Degree of Frequency) = # partners X # break points X # disease types 13 X 16 X 12=2496
	# samples	8	28
	** MAII score	** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score10) log2(8/15010)=-0.906890595608519 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score10) log2(28/249610)=-3.15611920191728 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: DNER [Title/Abstract] AND TRIP12 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	DNER(230411662)-TRIP12(230650571), # samples:1

Fusion gene breakpoints across DNER (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across TRIP12 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Breakpoints for DNER_TRIP12

RNA-seq based exon junction arranged fusion gene breakpoints from 8 resources (TCGA, CCLE, cBioPortal, GenBank, ChimerDB, ChimerKB, ChildHoodFusions, and GTEx). For the expressed sample information, go to Fusion Gene Sample section.

Hgene	Hchr	Hbp	Tgene	Tchr	Tbp
DNER	chr2	230411662	TRIP12	chr2	230650571
DNER	chr2	230411663	TRIP12	chr2	230650571
DNER	chr2	230406526	TRIP12	chr2	230765558
DNER	chr2	229546947	TRIP12	chr2	229785855

DNA-seq based exon junction arranged fusion gene breakpoints from dbVar. For the expressed sample information, go to Fusion Gene Sample section.

Hgene	Hchr	Hbp	Tgene	Tchr	Tbp	SV type
DNER	chr2	230450571	TRIP12	chr2	230634046	DUP
DNER	chr2	230559885	TRIP12	chr2	230667876	DUP
DNER	chr2	230530130	TRIP12	chr2	230634690	DUP
DNER	chr2	230508806	TRIP12	chr2	230727479	DUP
DNER	chr2	230449281	TRIP12	chr2	230635367	DUP
DNER	chr2	230418762	TRIP12	chr2	230628922	DUP
DNER	chr2	230493935	TRIP12	chr2	230657194	DUP
DNER	chr2	230304284	TRIP12	chr2	230721273	DUP
DNER	chr2	230493935	TRIP12	chr2	230657197	DUP
DNER	chr2	230575494	TRIP12	chr2	230752964	DUP
DNER	chr2	230517256	TRIP12	chr2	230642134	DUP
DNER	chr2	230573487	TRIP12	chr2	230764226	DUP
DNER	chr2	230566834	TRIP12	chr2	230689317	DUP
DNER	chr2	230491545	TRIP12	chr2	230657293	DUP
DNER	chr2	230491430	TRIP12	chr2	230775587	DUP
DNER	chr2	230487853	TRIP12	chr2	230709082	DUP
DNER	chr2	230421155	TRIP12	chr2	230632643	DUP
DNER	chr2	230304861	TRIP12	chr2	230718969	DUP

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Tumorigenic MoA (Mechanism of Action) Scenarios of Fusion Genes for DNER_TRIP12

To generate these tumorigenic scenario annotations, we implemented a deduction-first, retrieval-later computational framework. The pipeline first applies rule-guided reasoning across ten core mechanistic categories (M1–M10) derived from fusion gene biology to infer candidate mechanisms, tumorigenic scenarios, targeting points, and targeting backgrounds. To ensure empirical accountability, a governed Python workflow retrieves literature candidates via NCBI E-utilities and Europe PMC using tiered searches. Using JSON Schema-constrained LLM evidence judges (GPT-5.6 Luna and Terra), retrieved articles are evaluated for specificity and confidence without de novo PMID generation. This produces two distinct versions: a strict version restricted to high- or medium-confidence fusion-specific evidence, and an extended version incorporating broader gene-, pathway-, and contextual evidence.

* We have 10 tumorigenic mechanism categories of fusion genes as shown below.

Constitutively Active Kinases, Catalytic Domain Dysregulation, & Transmembrane Ligand Fusions	Aberrant Chimeric Transcription Factor / Fusion Transcription Factor Activity	Epigenetic Reprogramming / Histone Modifier Dysregulation	Chromatin Remodeling Dysregulation	Condensate-Driven Transcriptional Rewiring / LLP	Promoter / Enhancer Hijacking	Dominant-Negative Antagonism	Cell Cycle / Checkpoint Bypass / RNA Processing Dysregulation	Subcellular Mislocalization / Spatial Dysregulation	Nuclear Body / Sub-organellar Architecture Disruption & Differentiation Blockade

* Strict version: Restricted to high- or medium-confidence fusion-specific evidence.

Fusion Gene Name

Mechanism Category

Mechanism PubMed

Tumorigenic Scenarios

Tumorigenic Scenario PubMed

Targeting Points

Targeting PubMed

Mechanism Background

Mechanism Background PubMed

* Extended version: Includes all strict-level fusion evidence plus broader gene-, pathway-, and low-confidence contextual evidence.

Fusion Gene Name

Mechanism Category

Mechanism PubMed

Tumorigenic Scenarios

Tumorigenic Scenario PubMed

Targeting Points

Targeting PubMed

Mechanism Background

Mechanism Background PubMed

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	TRIP12	GO:0000209	protein polyubiquitination	30982744
Tgene	TRIP12	GO:0006511	ubiquitin-dependent protein catabolic process	18627766\|20208519\|30982744

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Fusion Genomic Features for DNER_TRIP12

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence) of In-frame fusion genes. FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
DNER	chr2	230411662	-	TRIP12	chr2	230650571	-	5.61e-07	1.00e+00

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence) of 5UTR-3CSD fusion genes (N-truncated cases).

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence) of 5CDS-3UTR fusion genes (C-truncated cases).

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of six genomic regulatory feature tracks across a ±5 kb window centered on the fusion breakpoints. We input the breakpoint sequences into AlphaGenome and obtained predicted genome tracks at single-base-pair resolution for each modality by running a single forward pass over the reference sequence. Specifically, for each breakpoint, AlphaGenome processed and returned predicted track data across diverse modalities, which were then averaged across all tracks within each output type and visualized across the ±5 kb window. The left panel shows the 5'-gene breakpoint ±5 kb area, and the right panel shows the 3'-gene breakpoint area, with tracks grouped by category: chromatin accessibility (DNase-seq, ATAC-seq), active transcription (RNA-seq, CAGE), and chromatin binding (ChIP-Histone, ChIP-TF).

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Fusion Gene ORF Annotations for DNER_TRIP12

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
In-frame	ENST00000341772	ENST00000283943	DNER	chr2	230411662	-	TRIP12	chr2	230650571	-
In-frame	ENST00000341772	ENST00000389044	DNER	chr2	230411662	-	TRIP12	chr2	230650571	-
In-frame	ENST00000341772	ENST00000389045	DNER	chr2	230411662	-	TRIP12	chr2	230650571	-

ORFfinder Result Based On The Fusion Transcript Sequences of the In-frame Fusion Genes.

Henst

Tenst

Hgene

Hchr

Hbp

Tgene

Tchr

Tbp

Seq length
(transcript)

Seq length
(peptide)

ORFfinder Result Based On The Fusion Transcript Sequences of the 5UTR-3CDS Fusion Genes for N-Truncated Protein Search.

Henst

Tenst

Hgene

Hchr

Hbp

Tgene

Tchr

Tbp

Seq length
(transcript)

Seq length
(peptide)

ORFfinder Result Based On The Fusion Transcript Sequences of the 5CDS-3UTR Fusion Genes for C-Truncated Protein Search.

Henst

Tenst

Hgene

Hchr

Hbp

Tgene

Tchr

Tbp

Seq length
(transcript)

Seq length
(peptide)

DeepORF Prediction of The Coding Potential Based on The Fusion Transcript Sequence of In-frame Fusion Genes. DeepORF is a Coding Potential Classifier Based on Convolutional Neural Network by Comparing the Real Ribo-seq Data. If the No-coding Score < 0.5 and Coding Score > 0.5, Then The In-frame Fusion Transcript is Predicted as Being Likely Translated.

Henst	Tenst	Hgene	Hchr	Hbp	Tgene	Tchr	Tbp	No-coding score	Coding score
ENST00000341772	ENST00000283943	DNER	chr2	230411662	TRIP12	chr2	230650571	1.20e-04	1.00e+00
ENST00000341772	ENST00000389044	DNER	chr2	230411662	TRIP12	chr2	230650571	7.68e-05	1.00e+00
ENST00000341772	ENST00000389045	DNER	chr2	230411662	TRIP12	chr2	230650571	7.68e-05	1.00e+00

DeepORF Prediction of The Coding Potential Based on The Fusion Transcript Sequence of 5UTR-3CDS Fusion Genes (Potential N-Truncated Proteins).

Henst

Tenst

Hgene

Hchr

Hbp

Tgene

Tchr

Tbp

No-coding score

Coding score

DeepORF Prediction of The Coding Potential Based on The Fusion Transcript Sequence of 5CDS-3UTR Fusion Genes (Potential C-Truncated Proteins).

Henst

Tenst

Hgene

Hchr

Hbp

Tgene

Tchr

Tbp

No-coding score

Coding score

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Fusion Protein Retained/Non-Retained Functional Features for DNER_TRIP12

Protein Level Annotation from FGviewer
* Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at download page. Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features (visualization across fusion protein length).

DNER_TRIP12_chr2-230411662_chr2-230650571.png

- In-frame and retained protein feature among the 13 regional features (texts).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

DNER

chr2:230411662

chr2:230650571

ENST00000341772

Q8NFT8

44_92

331.0

738.0

Domain

EGF-like 1

Hgene

DNER

chr2:230411662

chr2:230650571

ENST00000341772

Q8NFT8

94_133

331.0

738.0

Domain

EGF-like 2

Tgene

TRIP12

chr2:230411662

chr2:230650571

ENST00000283943

Q14669

1960_2067

1590.0

1993.0

Domain

HECT

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

DNER

chr2:230411662

chr2:230650571

ENST00000341772

Q8NFT8

309_348

331.0

738.0

Domain

EGF-like 3

Hgene

DNER

chr2:230411662

chr2:230650571

ENST00000341772

Q8NFT8

349_390

331.0

738.0

Domain

EGF-like 4

Hgene

DNER

chr2:230411662

chr2:230650571

ENST00000341772

Q8NFT8

392_428

331.0

738.0

Domain

EGF-like 5

Hgene

DNER

chr2:230411662

chr2:230650571

ENST00000341772

Q8NFT8

430_466

331.0

738.0

Domain

EGF-like 6

Hgene

DNER

chr2:230411662

chr2:230650571

ENST00000341772

Q8NFT8

468_503

331.0

738.0

Domain

EGF-like 7

Hgene

DNER

chr2:230411662

chr2:230650571

ENST00000341772

Q8NFT8

505_541

331.0

738.0

Domain

EGF-like 8%3B calcium-binding

Hgene

DNER

chr2:230411662

chr2:230650571

ENST00000341772

Q8NFT8

543_579

331.0

738.0

Domain

EGF-like 9

Hgene

DNER

chr2:230411662

chr2:230650571

ENST00000341772

Q8NFT8

546_568

331.0

738.0

Domain

Note=Follistatin-like

Hgene

DNER

chr2:230411662

chr2:230650571

ENST00000341772

Q8NFT8

581_617

331.0

738.0

Domain

EGF-like 10%3B calcium-binding

Hgene

DNER

chr2:230411662

chr2:230650571

ENST00000341772

Q8NFT8

35_640

331.0

738.0

Topological domain

Extracellular

Hgene

DNER

chr2:230411662

chr2:230650571

ENST00000341772

Q8NFT8

662_737

331.0

738.0

Topological domain

Cytoplasmic

Hgene

DNER

chr2:230411662

chr2:230650571

ENST00000341772

Q8NFT8

641_661

331.0

738.0

Transmembrane

Helical

Tgene

TRIP12

chr2:230411662

chr2:230650571

ENST00000283943

Q14669

1001_1014

1590.0

1993.0

Compositional bias

Basic residues

Tgene

TRIP12

chr2:230411662

chr2:230650571

ENST00000283943

Q14669

1017_1026

1590.0

1993.0

Compositional bias

Basic and acidic residues

Tgene

TRIP12

chr2:230411662

chr2:230650571

ENST00000283943

Q14669

1029_1040

1590.0

1993.0

Compositional bias

Low complexity

Tgene

TRIP12

chr2:230411662

chr2:230650571

ENST00000283943

Q14669

1041_1062

1590.0

1993.0

Compositional bias

Polar residues

Tgene

TRIP12

chr2:230411662

chr2:230650571

ENST00000283943

Q14669

119_132

1590.0

1993.0

Compositional bias

Polar residues

Tgene

TRIP12

chr2:230411662

chr2:230650571

ENST00000283943

Q14669

154_166

1590.0

1993.0

Compositional bias

Low complexity

Tgene

TRIP12

chr2:230411662

chr2:230650571

ENST00000283943

Q14669

175_216

1590.0

1993.0

Compositional bias

Low complexity

Tgene

TRIP12

chr2:230411662

chr2:230650571

ENST00000283943

Q14669

18_27

1590.0

1993.0

Compositional bias

Polar residues

Tgene

TRIP12

chr2:230411662

chr2:230650571

ENST00000283943

Q14669

1_10

1590.0

1993.0

Compositional bias

Polar residues

Tgene

TRIP12

chr2:230411662

chr2:230650571

ENST00000283943

Q14669

280_290

1590.0

1993.0

Compositional bias

Polar residues

Tgene

TRIP12

chr2:230411662

chr2:230650571

ENST00000283943

Q14669

326_338

1590.0

1993.0

Compositional bias

Polar residues

Tgene

TRIP12

chr2:230411662

chr2:230650571

ENST00000283943

Q14669

346_358

1590.0

1993.0

Compositional bias

Basic and acidic residues

Tgene

TRIP12

chr2:230411662

chr2:230650571

ENST00000283943

Q14669

360_371

1590.0

1993.0

Compositional bias

Polar residues

Tgene

TRIP12

chr2:230411662

chr2:230650571

ENST00000283943

Q14669

48_70

1590.0

1993.0

Compositional bias

Basic and acidic residues

Tgene

TRIP12

chr2:230411662

chr2:230650571

ENST00000283943

Q14669

78_88

1590.0

1993.0

Compositional bias

Polar residues

Tgene

TRIP12

chr2:230411662

chr2:230650571

ENST00000283943

Q14669

803_812

1590.0

1993.0

Compositional bias

Polar residues

Tgene

TRIP12

chr2:230411662

chr2:230650571

ENST00000283943

Q14669

948_973

1590.0

1993.0

Compositional bias

Low complexity

Tgene

TRIP12

chr2:230411662

chr2:230650571

ENST00000283943

Q14669

797_911

1590.0

1993.0

Domain

WWE

Tgene

TRIP12

chr2:230411662

chr2:230650571

ENST00000283943

Q14669

1407_1433

1590.0

1993.0

Region

Disordered

Tgene

TRIP12

chr2:230411662

chr2:230650571

ENST00000283943

Q14669

1568_1587

1590.0

1993.0

Region

Disordered

Tgene

TRIP12

chr2:230411662

chr2:230650571

ENST00000283943

Q14669

1571_1645

1590.0

1993.0

Region

Note=K-box

Tgene

TRIP12

chr2:230411662

chr2:230650571

ENST00000283943

Q14669

1_398

1590.0

1993.0

Region

Disordered

Tgene

TRIP12

chr2:230411662

chr2:230650571

ENST00000283943

Q14669

797_817

1590.0

1993.0

Region

Disordered

Tgene

TRIP12

chr2:230411662

chr2:230650571

ENST00000283943

Q14669

938_1080

1590.0

1993.0

Region

Disordered

Tgene

TRIP12

chr2:230411662

chr2:230650571

ENST00000283943

Q14669

532_563

1590.0

1993.0

Repeat

ARM 1

Tgene

TRIP12

chr2:230411662

chr2:230650571

ENST00000283943

Q14669

564_609

1590.0

1993.0

Repeat

ARM 2

Tgene

TRIP12

chr2:230411662

chr2:230650571

ENST00000283943

Q14669

610_648

1590.0

1993.0

Repeat

ARM 3

Tgene

TRIP12

chr2:230411662

chr2:230650571

ENST00000283943

Q14669

649_687

1590.0

1993.0

Repeat

ARM 4

Tgene

TRIP12

chr2:230411662

chr2:230650571

ENST00000283943

Q14669

688_729

1590.0

1993.0

Repeat

ARM 5

Tgene

TRIP12

chr2:230411662

chr2:230650571

ENST00000283943

Q14669

730_779

1590.0

1993.0

Repeat

ARM 6

- Retained PPIs in in-frame fusion.

Partner

Hgene

Hbp

Tgene

Tbp

ENST

UniProt

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Hgene

Hbp

Tgene

Tbp

ENST

UniProt

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Hgene

DNER

chr2:230411662

TRIP12

chr2:230650571

ENST00000341772

Q8NFT8

677_680

331.0

738.0

Region

AP1G1 and somatodendritic targeting

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Fusion Transcript Sequence for DNER_TRIP12

In-frame Fusion Transcript Sequences.

>DNER_TRIP12_ENST00000341772_ENST00000283943_230411662_230650571 length=6053nt 
 Breakpoint=1128nt
CGCAGCTGCAGGAGGCGCCCGGCCCGGCGGAGCAGCCCTAGCCGCCACCGTCGCTCTCGCAGCTCTCGTCGCCACTGCCACCGCCGCCGCCGTCACTGCGTCCTGGCTCCGGCTCCCGCGCCCTCCCGGCCGGCCATGCAGCCCCGCCGC
GCCCAGGCGCCCGGTGCGCAGCTGCTGCCCGCGCTGGCCCTGCTGCTGCTGCTGCTCGGAGCGGGGCCCCGAGGCAGCTCCCTGGCCAACCCGGTGCCCGCCGCGCCCCTGTCTGCGCCCGGGCCGTGCGCCGCGCAGCCCTGCCGGAAT
GGGGGTGTGTGCACCTCGCGCCCTGAGCCGGACCCGCAGCACCCGGCCCCCGCCGGCGAGCCTGGCTACAGCTGCACCTGCCCCGCCGGGATCTCCGGCGCCAACTGCCAGCTTGTTGCAGATCCTTGTGCCAGCAACCCTTGTCACCAT
GGCAACTGCAGCAGCAGCAGCAGCAGCAGCAGCGATGGCTACCTCTGCATTTGCAATGAAGGCTATGAAGGTCCCAACTGTGAACAGGCACTTCCCAGTCTCCCAGCCACTGGCTGGACCGAATCCATGGCACCCCGACAGCTTCAGCCT
GTTCCTGCTACTCAGGAGCCTGACAAAATCCTGCCTCGCTCTCAGGCAACGGTGACACTGCCTACCTGGCAGCCGAAAACAGGGCAGAAAGTTGTAGAAATGAAATGGGATCAAGTGGAGGTGATCCCAGATATTGCCTGTGGGAATGCC
AGTTCTAACAGCTCTGCGGGTGGCCGCCTGGTATCCTTTGAAGTGCCACAGAACACCTCAGTCAAGATTCGGCAAGATGCCACTGCCTCACTGATTTTGCTCTGGAAGGTCACGGCCACAGGATTCCAACAGTGCTCCCTCATAGATGGA
CGAAGTGTGACCCCCCTTCAGGCTTCAGGGGGACTGGTCCTCCTGGAGGAGATGCTCGCCTTGGGGAATAATCACTTTATTGGTTTTGTGAATGATTCTGTGACTAAGTCTATTGTGGCTTTGCGCTTAACTCTGGTGGTGAAGGTCAGC
ACCTGTGTGCCGGGGGAGAGTCACGCAAATGACTTGGAGTGTTCAGGAAAAGGAAAATGCACCACGAAGCCGTCAGAGCGTACTGTGAACCGAGAGGAGCTGCTGAAACAGGCGGAGTCTGTGATGCAGGACCTCGGCAGCTCACGGGCC
ATGTTAGAAATCCAGTATGAAAATGAGGTTGGTACAGGTCTTGGGCCTACACTGGAGTTTTATGCGCTTGTATCTCAGGAACTACAGAGAGCTGACTTGGGTCTTTGGAGAGGTGAAGAAGTAACTCTTAGCAATCCAAAAGGGAGCCAA
GAAGGGACCAAGTATATTCAAAACCTCCAGGGCCTGTTTGCGCTTCCCTTTGGTAGGACAGCAAAGCCAGCTCATATCGCAAAGGTTAAGATGAAGTTTCGCTTCTTAGGAAAATTAATGGCCAAGGCTATCATGGATTTCAGATTGGTG
GACCTTCCCCTTGGCTTACCCTTTTATAAATGGATGCTACGGCAAGAAACTTCACTGACATCACACGATTTGTTTGACATCGACCCAGTTGTAGCCAGATCAGTTTATCACCTAGAAGACATTGTCAGACAGAAGAAAAGACTTGAACAA
GATAAATCCCAGACCAAAGAGAGTCTACAGTATGCATTAGAAACCTTGACTATGAATGGCTGCTCAGTTGAAGATCTAGGACTGGATTTCACTCTGCCAGGGTTTCCCAATATCGAACTGAAGAAAGGAGGGAAGGATATACCAGTCACT
ATCCACAATTTAGAGGAGTATCTAAGACTGGTTATATTCTGGGCACTAAATGAAGGCGTTTCTAGGCAATTTGATTCGTTCAGAGATGGATTTGAATCAGTCTTCCCACTCAGTCATCTTCAGTACTTCTACCCGGAGGAACTGGATCAG
CTCCTTTGTGGCAGTAAAGCAGACACTTGGGATGCAAAGACACTGATGGAATGCTGTAGGCCTGATCATGGTTATACTCATGACAGTCGGGCTGTGAAGTTTTTGTTTGAGATTCTCAGTAGTTTTGATAATGAGCAGCAGAGGTTATTT
CTCCAGTTTGTGACTGGTAGCCCAAGATTGCCTGTTGGAGGATTCCGGAGTTTGAATCCACCTTTGACAATTGTCCGAAAGACGTTTGAATCAACAGAAAACCCAGATGACTTCTTGCCCTCTGTAATGACTTGTGTGAACTATCTTAAG
TTGCCGGACTATTCAAGCATTGAGATAATGCGTGAAAAACTGTTGATAGCAGCAAGAGAAGGGCAGCAGTCGTTCCATCTTTCCTGATCATAGCAAGAAATGCAGTGTCTGCCTGTTACAGCAAAAGAAACAAATCATGATTTCTTTTCT
AATGTTATCACCTGAGTCAAGGAAACATGTTACGCCTTCTTGTTGTAGGAAAAACGGCTTGCAGATTATAAAGAGACATTTGGTTGATATTCATTAATGGCCCCATGGACTTAAAGTGATCAGGCCCTAAAACGTTGTTGTGATGAGGTT
TCTTTAGCAAGTTCTTGTTTAAATTATCATTTATTTGATGAGTGAAGTTTTTAACATGCTTTGCTGTGTGAAATTTAAAAAAGGGATGTTTTTCCAGGCTGGAACAATAAATGTGGCTGTGCAGTTTAATTCTGGGCTGTGTGTATCCAT
CTAGCTAAGTCTGCAGTTTTCTTTCCTCCAAAGACAACTCTTGTACATAAGTACAGAAATTTAAGCTCACATGTATTTGACAAATATAGTTTAGTAGACTAGCTCTATGTGCTTTTCACTTTCCTCTGATTTTCTCTCCCTGATTCATTA
TTATCTGTGCAGCTCACAGTTTTTTTTTTGTATACAACTCACAGTTCTCAAATTTTCGTTACCCATGGGCTTCTGTTGTCCCATGTTCTCTCCAGTTAAGATCTAATTTAAAATTCATTGGATTGAAATTTATTGAATATAATTCAGCTT
TTGTAACTAGGTAGACTTTTCTTATAGTTTAGTTTTAATATAGTTTAGGGTATTACTGGCTTTTTCCCAGGTGACACACTAAGGACTGTTTACATGGCAATTCCAGCAGCAACAGCCTCTGGAATGAGACAAGGAAAGCTCATTTGTTTC
TTTTATGAAGGTTAAGAAGTCTACAGCTTGGGCTGGCCGGTATTTATTATTCTGTGGCCAGAGGATTTTAAATTAATGTAAATTTTTTAAACAAAATAAGCAGTTTTCCTTCCCTGTTGGAGTAAAAAAATTTTTTTCCCTTTGTTGTTT
TACGTTTTTGTTCATAGTCTTCTTTATTCCACGCTCCTCTTCCCCTTCTCCCAGTGCTGACTTGGGACAAAACAGTTCAGCCTTTGTCTCGACGCAGATAAAAGCACCTGTAAGCAATGCTGTCCAGTCATTTTATGTGCTGATTTCTCA
AATCTGCAATAATCCATCAGGTTAATGTTTTTACCTGAAAATAAAGAAAGTTTGCTTCACCTTTTTGTTTATAGTTTTGTGCTGTATGCATAACTTTCAATTGTATAGATGTATTTCAATGCAAGGAAATCCACATATCTCCATGATTCG
GGTCATGGCTGATTTTGCTATTCAAACAATTTATAATAGCAACTTGAAGAAACTAAAATGTGAAGAGAAAATGGGAGGAGATTCCTTCCTAAGGTCCAAAACTAGGCCTGTGGCATAAATTTGAAGGAATTTTCCATAATTCATCTCCTT
GAAAATAAGAGATGAGCTAGTTTTTTTTTTTAATTGAACTTTGAGAAATCAATTTTTTTGACTGTTCTGTAAGTTTTAATTAATTGACACAAAAGCCCTTTTCCCTATCCCACCACCCAAAAGAAACTCAGTGGCTTGTTTGACATAGAT
TGCTGTGTCAATTTACACTTAAATGGCCTTATATGGAAATGTCCCCTCCTGAGAGTTCACTTGGGCAGTGACCCCATTAAGTGGAAGGGAACTGTCAGAGGAGTTGGGGGCAGAGAATTCTCTCCCTGTCTCTGCAGAGACTGACAAGTG
AATGGCTTTTCCCTGAAATCCAAGAAGGGAATTGTGTTTCTGCAGTTTTCACCACTAACAGCACAGTTGCTGAGCAGCTTCATCAAGTGAAGTTAAAGACTGAAACAATTTGTTTTCAACTGTTCTGATATCTTCCTGCAAATTAAGCAC
AAGGATTTTTGTGTGAACATAGCATTTTGTTCCTGATTTTTAAAGGGTTCTGTTAAAATTTAGACATGTATAAACAAAATAATGTTTCATCTGTACTTGACATTTTATCCATGTTGCAGCCCTGGCAAATTTGGCCTCATTGATTCCAGC
ATCTAATAAGTATATATGATGATTTTGACTCAAACTCTAAAGTCTTGAGTGTTTCAAAGTCAGTCGTTACCTGTTTAAAAGCCTCAGCCTTTAGCTTATTCCTCCTTCAATACACGGGACCTTTGGTTAATTTGGGGCAGGAAAACTCTT
AAAGTAATCTCTCTTGGCAGAGGCCTTATTGCACCAGAGGGAAAAAGTATATACTTCATTTGCTGTTACTCCAGTTATGCCTTAAATTCATTTGCTTGGTAATCCTATCAACGAGCACTAACTTCTTAGTATACTTTAAACACTTAGTTG
GGTAACAACTGAGATTTTGTTGTCCTTTATTTTTTGCTGAGATGGAGTCAGTCAGATGTTAGTCATAGCTAACACCGAATTTGTGTTGTCATTTAGACAGTTACTGATTCGATCTGCTTTATATATGAGAACGTATTTTTAACTATTCCA
AGAAGGAAGAGGTAGCTAAATGTAATCCCCTCTTCCTATCCCCCCAGAAAACTGAACTGTAAGTTCTAGGTAGACTAATTGGGAGCAGACACGGAGTTTTAGATGCCTTAGCCAAACCCAGCAGAAACCTTTCACACAGCCACTCATCGT
AAGAAACGCAGATTTTTCTCTTCTCATGCTTGTCTCTGGTTCCCTGCATTTGTAGTGACAGAACTTTCACTAGCAGGATATAAAGAAAGTAATTATGCTTGGAGTCCCTCTTTACTGGGTTTGAGTTAGGTGCATAACATGGAAAGGAGT
GGTGCCTTCAAATGAATGTGACCACTCCGTATTGTGGAGTGACTTCCCTAGGGCATCCTATACATCCTACCACAGAAGGCCAAGGGACAGAGCACCAACTTCAGTATCCAAGAAATTAGATCCACAACTCTTGATTTTCCACACTGAGGA
CTGTCGCGAGTAAGTTGTAAGTTTGCCGTCTTCCTTCTGGCTTAGCAGGTGCTGCAGCTGTACTCTCGACTCCTGTCTGTGAGCGTGAGCTCAGGAAATGAGAGTGGAGTCTATTCCAAAAAAAAAATGTGATGAAGTTTTTCATAAAAG
TGCATTCATATGCCAAATCCTTTTTGGAGGATTCTGGATGCTATTGTTCATTTCTCTACTAGTAAAATGATCAAGCCTTCATTTATTTTAGGCTTTGTTTTTTGATCCATTTTGTTTTCCCTGCTGTAATGAGAATAATTGTTTGGAAAT
GTCATATTCTGTATTTATGATTCTCTGAGAAATGCTTTTGTATAAGTCTTAGGTTTGACATTGCAGTAGTTGACATACACGGTAAAGGATAACCTAGTGACAAATCACTGAAGATGCTTCCTTTGTTACCTCAAAAAAAAAAATCCAGAC
AAAATAGCATTTATAAATATAGAAAACAGGATTGGCTGTTTTCCAAGAACTTCAAGTTAACAATTCTTATGCAAGGAAAAGTTCTTAATGCTAAAGACTTGTTCTGCATGAAGGAGACATTCTTTAATAATGGAAGAGGTGGTTTTATTT
TTACTACAAGCCGACTCATATTTCCAAACCTATAACCAATTGCTGATCTCCTGTGTAAAGCATTTTTTTCCTTTTATCTGAAACAGTGATTTATATGAACTGTTGGAATAATGGAACCTCAAACTACAGATGTGTATGTAAAATTGCATA
AATGCACTGACTTCCTTCTCCCTGACTATATTTTTAATAAACAGCATTATCCT

>DNER_TRIP12_ENST00000341772_ENST00000389044_230411662_230650571 length=2450nt 
 Breakpoint=1128nt
CGCAGCTGCAGGAGGCGCCCGGCCCGGCGGAGCAGCCCTAGCCGCCACCGTCGCTCTCGCAGCTCTCGTCGCCACTGCCACCGCCGCCGCCGTCACTGCGTCCTGGCTCCGGCTCCCGCGCCCTCCCGGCCGGCCATGCAGCCCCGCCGC
GCCCAGGCGCCCGGTGCGCAGCTGCTGCCCGCGCTGGCCCTGCTGCTGCTGCTGCTCGGAGCGGGGCCCCGAGGCAGCTCCCTGGCCAACCCGGTGCCCGCCGCGCCCCTGTCTGCGCCCGGGCCGTGCGCCGCGCAGCCCTGCCGGAAT
GGGGGTGTGTGCACCTCGCGCCCTGAGCCGGACCCGCAGCACCCGGCCCCCGCCGGCGAGCCTGGCTACAGCTGCACCTGCCCCGCCGGGATCTCCGGCGCCAACTGCCAGCTTGTTGCAGATCCTTGTGCCAGCAACCCTTGTCACCAT
GGCAACTGCAGCAGCAGCAGCAGCAGCAGCAGCGATGGCTACCTCTGCATTTGCAATGAAGGCTATGAAGGTCCCAACTGTGAACAGGCACTTCCCAGTCTCCCAGCCACTGGCTGGACCGAATCCATGGCACCCCGACAGCTTCAGCCT
GTTCCTGCTACTCAGGAGCCTGACAAAATCCTGCCTCGCTCTCAGGCAACGGTGACACTGCCTACCTGGCAGCCGAAAACAGGGCAGAAAGTTGTAGAAATGAAATGGGATCAAGTGGAGGTGATCCCAGATATTGCCTGTGGGAATGCC
AGTTCTAACAGCTCTGCGGGTGGCCGCCTGGTATCCTTTGAAGTGCCACAGAACACCTCAGTCAAGATTCGGCAAGATGCCACTGCCTCACTGATTTTGCTCTGGAAGGTCACGGCCACAGGATTCCAACAGTGCTCCCTCATAGATGGA
CGAAGTGTGACCCCCCTTCAGGCTTCAGGGGGACTGGTCCTCCTGGAGGAGATGCTCGCCTTGGGGAATAATCACTTTATTGGTTTTGTGAATGATTCTGTGACTAAGTCTATTGTGGCTTTGCGCTTAACTCTGGTGGTGAAGGTCAGC
ACCTGTGTGCCGGGGGAGAGTCACGCAAATGACTTGGAGTGTTCAGGAAAAGGAAAATGCACCACGAAGCCGTCAGAGCGTACTGTGAACCGAGAGGAGCTGCTGAAACAGGCGGAGTCTGTGATGCAGGACCTCGGCAGCTCACGGGCC
ATGTTAGAAATCCAGTATGAAAATGAGGTTGGTACAGGTCTTGGGCCTACACTGGAGTTTTATGCGCTTGTATCTCAGGAACTACAGAGAGCTGACTTGGGTCTTTGGAGAGGTGAAGAAGTAACTCTTAGCAATCCAAAAGGGAGCCAA
GAAGGGACCAAGTATATTCAAAACCTCCAGGGCCTGTTTGCGCTTCCCTTTGGTAGGACAGCAAAGCCAGCTCATATCGCAAAGGTTAAGATGAAGTTTCGCTTCTTAGGAAAATTAATGGCCAAGGCTATCATGGATTTCAGATTGGTG
GACCTTCCCCTTGGCTTACCCTTTTATAAATGGATGCTACGGCAAGAAACTTCACTGACATCACACGATTTGTTTGACATCGACCCAGTTGTAGCCAGATCAGTTTATCACCTAGAAGACATTGTCAGACAGAAGAAAAGACTTGAACAA
GATAAATCCCAGACCAAAGAGAGTCTACAGTATGCATTAGAAACCTTGACTATGAATGGCTGCTCAGTTGAAGATCTAGGACTGGATTTCACTCTGCCAGGGTTTCCCAATATCGAACTGAAGAAAGGAGGGAAGGATATACCAGTCACT
ATCCACAATTTAGAGGAGTATCTAAGACTGGTTATATTCTGGGCACTAAATGAAGGCGTTTCTAGGCAATTTGATTCGTTCAGAGATGGATTTGAATCAGTCTTCCCACTCAGTCATCTTCAGTACTTCTACCCGGAGGAACTGGATCAG
CTCCTTTGTGGCAGTAAAGCAGACACTTGGGATGCAAAGACACTGATGGAATGCTGTAGGCCTGATCATGGTTATACTCATGACAGTCGGGCTGTGAAGTTTTTGTTTGAGATTCTCAGTAGTTTTGATAATGAGCAGCAGAGGTTATTT
CTCCAGTTTGTGACTGGTAGCCCAAGATTGCCTGTTGGAGGATTCCGGAGTTTGAATCCACCTTTGACAATTGTCCGAAAGACGTTTGAATCAACAGAAAACCCAGATGACTTCTTGCCCTCTGTAATGACTTGTGTGAACTATCTTAAG
TTGCCGGACTATTCAAGCATTGAGATAATGCGTGAAAAACTGTTGATAGCAGCAAGAGAAGGGCAGCAGTCGTTCCATCTTTCCTGATCATAGCAAGAAATGCAGTGTCTGCCTGTTACAGCAAAAGAAACAAATCATGATTTCTTTTCT
AATGTTATCACCTGAGTCAAGGAAACATGTTACGCCTTCTTGTTGTAGGA

>DNER_TRIP12_ENST00000341772_ENST00000389045_230411662_230650571 length=2450nt 
 Breakpoint=1128nt
CGCAGCTGCAGGAGGCGCCCGGCCCGGCGGAGCAGCCCTAGCCGCCACCGTCGCTCTCGCAGCTCTCGTCGCCACTGCCACCGCCGCCGCCGTCACTGCGTCCTGGCTCCGGCTCCCGCGCCCTCCCGGCCGGCCATGCAGCCCCGCCGC
GCCCAGGCGCCCGGTGCGCAGCTGCTGCCCGCGCTGGCCCTGCTGCTGCTGCTGCTCGGAGCGGGGCCCCGAGGCAGCTCCCTGGCCAACCCGGTGCCCGCCGCGCCCCTGTCTGCGCCCGGGCCGTGCGCCGCGCAGCCCTGCCGGAAT
GGGGGTGTGTGCACCTCGCGCCCTGAGCCGGACCCGCAGCACCCGGCCCCCGCCGGCGAGCCTGGCTACAGCTGCACCTGCCCCGCCGGGATCTCCGGCGCCAACTGCCAGCTTGTTGCAGATCCTTGTGCCAGCAACCCTTGTCACCAT
GGCAACTGCAGCAGCAGCAGCAGCAGCAGCAGCGATGGCTACCTCTGCATTTGCAATGAAGGCTATGAAGGTCCCAACTGTGAACAGGCACTTCCCAGTCTCCCAGCCACTGGCTGGACCGAATCCATGGCACCCCGACAGCTTCAGCCT
GTTCCTGCTACTCAGGAGCCTGACAAAATCCTGCCTCGCTCTCAGGCAACGGTGACACTGCCTACCTGGCAGCCGAAAACAGGGCAGAAAGTTGTAGAAATGAAATGGGATCAAGTGGAGGTGATCCCAGATATTGCCTGTGGGAATGCC
AGTTCTAACAGCTCTGCGGGTGGCCGCCTGGTATCCTTTGAAGTGCCACAGAACACCTCAGTCAAGATTCGGCAAGATGCCACTGCCTCACTGATTTTGCTCTGGAAGGTCACGGCCACAGGATTCCAACAGTGCTCCCTCATAGATGGA
CGAAGTGTGACCCCCCTTCAGGCTTCAGGGGGACTGGTCCTCCTGGAGGAGATGCTCGCCTTGGGGAATAATCACTTTATTGGTTTTGTGAATGATTCTGTGACTAAGTCTATTGTGGCTTTGCGCTTAACTCTGGTGGTGAAGGTCAGC
ACCTGTGTGCCGGGGGAGAGTCACGCAAATGACTTGGAGTGTTCAGGAAAAGGAAAATGCACCACGAAGCCGTCAGAGCGTACTGTGAACCGAGAGGAGCTGCTGAAACAGGCGGAGTCTGTGATGCAGGACCTCGGCAGCTCACGGGCC
ATGTTAGAAATCCAGTATGAAAATGAGGTTGGTACAGGTCTTGGGCCTACACTGGAGTTTTATGCGCTTGTATCTCAGGAACTACAGAGAGCTGACTTGGGTCTTTGGAGAGGTGAAGAAGTAACTCTTAGCAATCCAAAAGGGAGCCAA
GAAGGGACCAAGTATATTCAAAACCTCCAGGGCCTGTTTGCGCTTCCCTTTGGTAGGACAGCAAAGCCAGCTCATATCGCAAAGGTTAAGATGAAGTTTCGCTTCTTAGGAAAATTAATGGCCAAGGCTATCATGGATTTCAGATTGGTG
GACCTTCCCCTTGGCTTACCCTTTTATAAATGGATGCTACGGCAAGAAACTTCACTGACATCACACGATTTGTTTGACATCGACCCAGTTGTAGCCAGATCAGTTTATCACCTAGAAGACATTGTCAGACAGAAGAAAAGACTTGAACAA
GATAAATCCCAGACCAAAGAGAGTCTACAGTATGCATTAGAAACCTTGACTATGAATGGCTGCTCAGTTGAAGATCTAGGACTGGATTTCACTCTGCCAGGGTTTCCCAATATCGAACTGAAGAAAGGAGGGAAGGATATACCAGTCACT
ATCCACAATTTAGAGGAGTATCTAAGACTGGTTATATTCTGGGCACTAAATGAAGGCGTTTCTAGGCAATTTGATTCGTTCAGAGATGGATTTGAATCAGTCTTCCCACTCAGTCATCTTCAGTACTTCTACCCGGAGGAACTGGATCAG
CTCCTTTGTGGCAGTAAAGCAGACACTTGGGATGCAAAGACACTGATGGAATGCTGTAGGCCTGATCATGGTTATACTCATGACAGTCGGGCTGTGAAGTTTTTGTTTGAGATTCTCAGTAGTTTTGATAATGAGCAGCAGAGGTTATTT
CTCCAGTTTGTGACTGGTAGCCCAAGATTGCCTGTTGGAGGATTCCGGAGTTTGAATCCACCTTTGACAATTGTCCGAAAGACGTTTGAATCAACAGAAAACCCAGATGACTTCTTGCCCTCTGTAATGACTTGTGTGAACTATCTTAAG
TTGCCGGACTATTCAAGCATTGAGATAATGCGTGAAAAACTGTTGATAGCAGCAAGAGAAGGGCAGCAGTCGTTCCATCTTTCCTGATCATAGCAAGAAATGCAGTGTCTGCCTGTTACAGCAAAAGAAACAAATCATGATTTCTTTTCT
AATGTTATCACCTGAGTCAAGGAAACATGTTACGCCTTCTTGTTGTAGGA

N-Truncated Transcript (5UTR-3CDS) Sequences

C-Truncated Transcript (5CDS-3UTR) Sequences

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Fusion Protein Sequence for DNER_TRIP12

In-frame Fusion Protein Sequences.

N-Truncated Protein (5UTR-3CDS) Sequences

C-Truncated Protein (5CDS-3UTR) Sequences

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Personalized Fusion Protein Sequence for DNER_TRIP12

TCGA Kinase/DNA-binding Domain Mutated Fusion Protein Sequences

Num

Gene Group

Domain Loci

Fusion Protein ID

Fusion Gene Name

Partner

Mutated Residue in WT Protein

Seq. Length

Mutated Residue in Fusion Protein

CCLE Kinase/DNA-binding Domain Mutated Fusion Protein Sequences

Num

Gene Group

Domain Loci

Fusion Protein ID

Fusion Gene Name

Partner

Mutated Residue in WT Protein

Seq. Length

Mutated Residue in Fusion Protein

TCGA All Mutated Fusion Protein Sequences

Fusion Protein ID

Sample ID

Mutated Partner

AAchange in WT

Seq. Length

AAchange in Fusion

CCLE All Mutated Fusion Protein Sequences

Fusion Protein ID

Sample ID

Mutated Partner

AAchange in WT

Seq. Length

AAchange in Fusion

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Fusion Gene Exprssed Samples for DNER_TRIP12

RNA-seq based fusion gene expressed samples.

Source	Study	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB		BRCA	TCGA-AN-A0FJ-01A	DNER	chr2	230411662	-	TRIP12	chr2	230650571	-
TCGAfusionPortal		BRCA	TCGA-AN-A0FJ-01A	DNER	chr2	230411663	-	TRIP12	chr2	230650571	-
cBioPortal	POG570_BCGSC_2020	MIXED	28126	DNER	chr2	230406526		TRIP12	chr2	230765558
cBioPortal	BRCA_TCGA_PAN_CAN_ATLAS_2018	BRCA	TCGA-AN-A0FJ-01	DNER	chr2	229546947		TRIP12	chr2	229785855

DNA-seq based fusion gene expressed samples.

Source

Study

Disease

Sample

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

SV type

dbVar

estd55

Blood

SPC_138

DNER

chr2

230575494

TRIP12

chr2

230752964

DUP

dbVar

nstd100

Unknown_Cell

DNER

chr2

230304861

TRIP12

chr2

230718969

DUP

dbVar

nstd102

Unknown_Cell

DNER

chr2

230421155

TRIP12

chr2

230632643

DUP

dbVar

nstd102

Unknown_Cell

DNER

chr2

230487853

TRIP12

chr2

230709082

DUP

dbVar

nstd102

Unknown_Cell

DNER

chr2

230491430

TRIP12

chr2

230775587

DUP

dbVar

nstd102

Unknown_Cell

DNER

chr2

230491545

TRIP12

chr2

230657293

DUP

dbVar

nstd102

Unknown_Cell

DNER

chr2

230566834

TRIP12

chr2

230689317

DUP

dbVar

nstd102

Unknown_Cell

DNER

chr2

230573487

TRIP12

chr2

230764226

DUP

dbVar

nstd113

Unknown_Cell

Unknown_Set_72805

DNER

chr2

230517256

TRIP12

chr2

230642134

DUP

dbVar

nstd151

Unknown_Cell

DNER

chr2

230450571

TRIP12

chr2

230634046

DUP

dbVar

nstd200

Unknown_Cell

DNER

chr2

230493935

TRIP12

chr2

230657197

DUP

dbVar

nstd223

Unknown_Cell

DNER

chr2

230304284

TRIP12

chr2

230721273

DUP

dbVar

nstd223

Unknown_Cell

DNER

chr2

230493935

TRIP12

chr2

230657194

DUP

dbVar

nstd229

Unknown_Cell

DNER

chr2

230304284

TRIP12

chr2

230721273

DUP

dbVar

nstd229

Unknown_Cell

DNER

chr2

230418762

TRIP12

chr2

230628922

DUP

dbVar

nstd229

Unknown_Cell

DNER

chr2

230449281

TRIP12

chr2

230635367

DUP

dbVar

nstd229

Unknown_Cell

DNER

chr2

230493935

TRIP12

chr2

230657197

DUP

dbVar

nstd229

Unknown_Cell

DNER

chr2

230508806

TRIP12

chr2

230727479

DUP

dbVar

nstd229

Unknown_Cell

DNER

chr2

230530130

TRIP12

chr2

230634690

DUP

dbVar

nstd229

Unknown_Cell

DNER

chr2

230559885

TRIP12

chr2

230667876

DUP

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Related Drugs for DNER_TRIP12

PubMed Abstract Search With ['A-B' AND 'drug'], ['A::B' AND 'drug']
* For more details on the Studied, Reported, Approved Drugs targeting this fusion gene, Go to FusionPub.

PMID

Fusion Gene Name

Drug

Study Title

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status