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	Fusion Gene Summary
	Fusion Gene Breakpoints
	Tumorigenic MoA (Mechanism of Action) Scenarios of Fusion Geness
	Fusion Genomic Features
	Fusion Gene ORF Annotations
	Fusion Protein Retained/Non-Retained Functional Features
	Fusion Transcript Sequences
	Fusion Protein Sequences
	Personalized Fusion Protein Sequences
	Fusion Gene Expressed Samples
	Related Drugs

Fusion gene:CADPS2_XRCC6BP1 (FusionGDB2 ID:HG93664TG91419)

Fusion Gene Summary for CADPS2_XRCC6BP1

Fusion gene summary

Fusion gene information	Fusion gene name: CADPS2_XRCC6BP1
	Fusion gene ID: hg93664tg91419
		Hgene	Tgene
	Gene symbol	CADPS2	XRCC6BP1
	Gene ID	93664	91419
	Gene name	calcium dependent secretion activator 2	ATP23 metallopeptidase and ATP synthase assembly factor homolog
	Synonyms	CAPS2	KUB3\|XRCC6BP1
	Cytomap	7q31.32	12q14.1
	Type of gene	protein-coding	protein-coding
	Description	calcium-dependent secretion activator 2CAPS-2Ca++-dependent secretion activator 2Ca2+ dependent secretion activator 2Ca2+-dependent activator protein for secretion 2calcium-dependent activator protein for secretion 2	mitochondrial inner membrane protease ATP23 homologKu70-binding protein 3XRCC6-binding protein 1
	Modification date	20240403	20240305
	UniProtAcc	.	.
	Ensembl transtripts involved in fusion gene	ENST00000313070, ENST00000334010, ENST00000412584, ENST00000449022, ENST00000476131,
Fusion gene scores	* DoF score	* DoF score (Degree of Frequency) = # partners X # break points X # disease types 15 X 18 X 10=2700	* DoF score (Degree of Frequency) = # partners X # break points X # disease types 3 X 26 X 11=858
	# samples	83	44
	** MAII score	** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score10) log2(83/270010)=-1.70177616570391 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score10) log2(44/85810)=-0.963474123974886 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: CADPS2 [Title/Abstract] AND XRCC6BP1 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	CADPS2(122526052)-XRCC6BP1(58345544), # samples:1

Fusion gene breakpoints across CADPS2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across XRCC6BP1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Breakpoints for CADPS2_XRCC6BP1

RNA-seq based exon junction arranged fusion gene breakpoints from 8 resources (TCGA, CCLE, cBioPortal, GenBank, ChimerDB, ChimerKB, ChildHoodFusions, and GTEx). For the expressed sample information, go to Fusion Gene Sample section.

Hgene	Hchr	Hbp	Tgene	Tchr	Tbp
CADPS2	chr7	122526053	ATP23	chr12	58345541
CADPS2	chr7	122885999	ATP23	chr12	57951758
CADPS2	chr7	122526052	XRCC6BP1	chr12	122526052
CADPS2	chr7	122526052	XRCC6BP1	chr12	58345540

DNA-seq based exon junction arranged fusion gene breakpoints from dbVar. For the expressed sample information, go to Fusion Gene Sample section.

Hgene

Hchr

Hbp

Tgene

Tchr

Tbp

SV type

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Tumorigenic MoA (Mechanism of Action) Scenarios of Fusion Genes for CADPS2_XRCC6BP1

To generate these tumorigenic scenario annotations, we implemented a deduction-first, retrieval-later computational framework. The pipeline first applies rule-guided reasoning across ten core mechanistic categories (M1–M10) derived from fusion gene biology to infer candidate mechanisms, tumorigenic scenarios, targeting points, and targeting backgrounds. To ensure empirical accountability, a governed Python workflow retrieves literature candidates via NCBI E-utilities and Europe PMC using tiered searches. Using JSON Schema-constrained LLM evidence judges (GPT-5.6 Luna and Terra), retrieved articles are evaluated for specificity and confidence without de novo PMID generation. This produces two distinct versions: a strict version restricted to high- or medium-confidence fusion-specific evidence, and an extended version incorporating broader gene-, pathway-, and contextual evidence.

* We have 10 tumorigenic mechanism categories of fusion genes as shown below.

Constitutively Active Kinases, Catalytic Domain Dysregulation, & Transmembrane Ligand Fusions	Aberrant Chimeric Transcription Factor / Fusion Transcription Factor Activity	Epigenetic Reprogramming / Histone Modifier Dysregulation	Chromatin Remodeling Dysregulation	Condensate-Driven Transcriptional Rewiring / LLP	Promoter / Enhancer Hijacking	Dominant-Negative Antagonism	Cell Cycle / Checkpoint Bypass / RNA Processing Dysregulation	Subcellular Mislocalization / Spatial Dysregulation	Nuclear Body / Sub-organellar Architecture Disruption & Differentiation Blockade

* Strict version: Restricted to high- or medium-confidence fusion-specific evidence.

Fusion Gene Name

Mechanism Category

Mechanism PubMed

Tumorigenic Scenarios

Tumorigenic Scenario PubMed

Targeting Points

Targeting PubMed

Mechanism Background

Mechanism Background PubMed

* Extended version: Includes all strict-level fusion evidence plus broader gene-, pathway-, and low-confidence contextual evidence.

Fusion Gene Name

Mechanism Category

Mechanism PubMed

Tumorigenic Scenarios

Tumorigenic Scenario PubMed

Targeting Points

Targeting PubMed

Mechanism Background

Mechanism Background PubMed

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

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Fusion Genomic Features for CADPS2_XRCC6BP1

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence) of In-frame fusion genes. FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
CADPS2	chr7	122526052	-	XRCC6BP1	chr12	58345544	+	2.24e-09	1.00e+00

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence) of 5UTR-3CSD fusion genes (N-truncated cases).

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence) of 5CDS-3UTR fusion genes (C-truncated cases).

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of six genomic regulatory feature tracks across a ±5 kb window centered on the fusion breakpoints. We input the breakpoint sequences into AlphaGenome and obtained predicted genome tracks at single-base-pair resolution for each modality by running a single forward pass over the reference sequence. Specifically, for each breakpoint, AlphaGenome processed and returned predicted track data across diverse modalities, which were then averaged across all tracks within each output type and visualized across the ±5 kb window. The left panel shows the 5'-gene breakpoint ±5 kb area, and the right panel shows the 3'-gene breakpoint area, with tracks grouped by category: chromatin accessibility (DNase-seq, ATAC-seq), active transcription (RNA-seq, CAGE), and chromatin binding (ChIP-Histone, ChIP-TF).

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Fusion Gene ORF Annotations for CADPS2_XRCC6BP1

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-3UTR	ENST00000313070	ENST00000546709	CADPS2	chr7	122526052	-	XRCC6BP1	chr12	58345544	+
5CDS-3UTR	ENST00000334010	ENST00000546709	CADPS2	chr7	122526052	-	XRCC6BP1	chr12	58345544	+
5CDS-3UTR	ENST00000412584	ENST00000546709	CADPS2	chr7	122526052	-	XRCC6BP1	chr12	58345544	+
5CDS-3UTR	ENST00000449022	ENST00000546709	CADPS2	chr7	122526052	-	XRCC6BP1	chr12	58345544	+
In-frame	ENST00000313070	ENST00000300145	CADPS2	chr7	122526052	-	XRCC6BP1	chr12	58345544	+
In-frame	ENST00000334010	ENST00000300145	CADPS2	chr7	122526052	-	XRCC6BP1	chr12	58345544	+
In-frame	ENST00000412584	ENST00000300145	CADPS2	chr7	122526052	-	XRCC6BP1	chr12	58345544	+
In-frame	ENST00000449022	ENST00000300145	CADPS2	chr7	122526052	-	XRCC6BP1	chr12	58345544	+

ORFfinder Result Based On The Fusion Transcript Sequences of the In-frame Fusion Genes.

Henst	Tenst	Hgene	Hchr	Hbp	Tgene	Tchr	Tbp	Seq length (transcript)	Seq length (peptide)
ENST00000313070	ENST00000300145	CADPS2	chr7	122526052	XRCC6BP1	chr12	58345544	761	569
ENST00000334010	ENST00000300145	CADPS2	chr7	122526052	XRCC6BP1	chr12	58345544	761	254
ENST00000412584	ENST00000300145	CADPS2	chr7	122526052	XRCC6BP1	chr12	58345544	460	254
ENST00000449022	ENST00000300145	CADPS2	chr7	122526052	XRCC6BP1	chr12	58345544	359	254

ORFfinder Result Based On The Fusion Transcript Sequences of the 5UTR-3CDS Fusion Genes for N-Truncated Protein Search.

Henst

Tenst

Hgene

Hchr

Hbp

Tgene

Tchr

Tbp

Seq length
(transcript)

Seq length
(peptide)

ORFfinder Result Based On The Fusion Transcript Sequences of the 5CDS-3UTR Fusion Genes for C-Truncated Protein Search.

Henst

Tenst

Hgene

Hchr

Hbp

Tgene

Tchr

Tbp

Seq length
(transcript)

Seq length
(peptide)

DeepORF Prediction of The Coding Potential Based on The Fusion Transcript Sequence of In-frame Fusion Genes. DeepORF is a Coding Potential Classifier Based on Convolutional Neural Network by Comparing the Real Ribo-seq Data. If the No-coding Score < 0.5 and Coding Score > 0.5, Then The In-frame Fusion Transcript is Predicted as Being Likely Translated.

Henst	Tenst	Hgene	Hchr	Hbp	Tgene	Tchr	Tbp	No-coding score	Coding score
ENST00000313070	ENST00000300145	CADPS2	chr7	122526052	XRCC6BP1	chr12	58345544	3.28e-03	9.97e-01
ENST00000334010	ENST00000300145	CADPS2	chr7	122526052	XRCC6BP1	chr12	58345544	3.28e-03	9.97e-01
ENST00000412584	ENST00000300145	CADPS2	chr7	122526052	XRCC6BP1	chr12	58345544	1.28e-03	9.99e-01
ENST00000449022	ENST00000300145	CADPS2	chr7	122526052	XRCC6BP1	chr12	58345544	1.28e-03	9.99e-01

DeepORF Prediction of The Coding Potential Based on The Fusion Transcript Sequence of 5UTR-3CDS Fusion Genes (Potential N-Truncated Proteins).

Henst

Tenst

Hgene

Hchr

Hbp

Tgene

Tchr

Tbp

No-coding score

Coding score

DeepORF Prediction of The Coding Potential Based on The Fusion Transcript Sequence of 5CDS-3UTR Fusion Genes (Potential C-Truncated Proteins).

Henst	Tenst	Hgene	Hchr	Hbp	Tgene	Tchr	Tbp	No-coding score	Coding score
ENST00000313070	ENST00000546709	CADPS2	chr7	122526052	XRCC6BP1	chr12	58345544	0.00e+00	4.18e-02
ENST00000334010	ENST00000546709	CADPS2	chr7	122526052	XRCC6BP1	chr12	58345544	0.00e+00	4.18e-02
ENST00000412584	ENST00000546709	CADPS2	chr7	122526052	XRCC6BP1	chr12	58345544	0.00e+00	1.53e-02
ENST00000449022	ENST00000546709	CADPS2	chr7	122526052	XRCC6BP1	chr12	58345544	0.00e+00	1.24e-02

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Fusion Protein Retained/Non-Retained Functional Features for CADPS2_XRCC6BP1

Protein Level Annotation from FGviewer
* Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at download page. Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features (visualization across fusion protein length).

No matching images found for ${hg}_${tg}.

- In-frame and retained protein feature among the 13 regional features (texts).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- Retained PPIs in in-frame fusion.

Partner

Hgene

Hbp

Tgene

Tbp

ENST

UniProt

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Hgene

Hbp

Tgene

Tbp

ENST

UniProt

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Fusion Transcript Sequence for CADPS2_XRCC6BP1

In-frame Fusion Transcript Sequences.

>CADPS2_XRCC6BP1_ENST00000313070_ENST00000300145_122526052_58345544 length=1566nt 
 Breakpoint=761nt
ATTCAATTCCACGTGTTGCTTGTTGTAGGCGCCACAGGTTCCCCACCTGCGTCCGGGCGCTCGGGCGGCTCCGCCTCTGCCGGCGGGCTCTGGGGAACCGCTGGGTCGGCGCGCCCGGGGCTGGCGGAGCAATTCCTGAGGCGCCCAAGC
TCACCCCCAACGCTAACTCCGCCTATTCAGTCCCGGCGGCTCCCCCTCTCCCCCCTCCCAATCCTCCTCCCGGCTCCTGCCCGCCCCTTTCGCCCTGGTGGTAGGAAACACTCCTGAATCTAACTCGACGTGTCCGGAAAGCCCTGGCCA
GTTTTCCTTTCGTTCTGCGGCCGCTGCAGCCAGCCCCGCGGCTCCCTCAGACCCGCGGGCGCAGCCGCCGGGGGTGAGGCGCTTGGGGACCGCGGGCCGAGCGGCGGGGATCCCCGAGCACCATGCTGGACCCGTCTTCCAGCGAAGAGG
AGTCGGACGAGGGGCTGGAAGAGGAAAGCCGCGATGTGCTGGTGGCAGCCGGCAGCTCGCAGCGAGCTCCTCCAGCCCCGACTCGGGAAGGGCGGCGGGACGCGCCGGGGCGCGCGGGCGGCGGCGGCGCGGCCAGATCTGTGAGCCCGA
GCCCCTCTGTGCTCAGCGAGGGGCGAGACGAGCCCCAGCGGCAGCTGGACGATGAGCAGGAGCGGAGGATCCGCCTGCAGCTCTACGTCTTCGTCGTGAGGTGCATCGCGTACCCCTTCAACGCCAAGCAGCCCACCGACATGGCCCGGA
GGCAGCAGAAGATAGTTTTGTGCCAGAATAATATCCATAATCAGGCCCATATGAACAGAGTGGTCACACACGAGCTTATTCATGCATTTGATCATTGTCGTGCCCATGTCGACTGGTTCACCAACATCAGACATTTGGCGTGCTCAGAGG
TTCGAGCTGCTAACCTTAGTGGAGACTGCTCACTTGTCAATGAAATATTCAGGTTACATTTTGGATTAAAACAACACCACCAGACTTGTGTGCGAGACAGAGCCACTCTTTCTATCCTGGCTGTTAGGAATATCAGCAAAGAAGTAGCTA
AAAAGGCTGTTGATGAAGTTTTTGAATCTTGTTTCAATGACCATGAACCTTTTGGAAGGATCCCACATAACAAGACTTATGCAAGATATGCTCACAGAGACTTTGAAAACCGTGATCGGTATTATTCAAATATATGAGCACAATGACATT
TTTATATTACAGAGCTTCCATCATCATGAAGAAAAAAAAATTTGGTTCTCAAGTGAACAAACATATAAAATGTAAACAATCCCTACAATCCAGATAAAACAGAGAAGACTGTGATTCTAGCATATTATCAGAAAAAGTAACTATGGCAAA
AAATGAAACTGCTTTAAACTCCAAGGCAGAAATTGTATCTTTATAGCTAACCATTTAGTAAATAAATACATTACATTTTTGTATTTTAGTCATTTGTTTTTATTACATGTGATTATTTTAAAATTTGATTATGAAACCTGTGAAGTGTGC
TCTTCCATGATGTTGATAGGTGACCACTGTTGGTATTTACATTAAATGTAAAGAAATGTGTACTGA

>CADPS2_XRCC6BP1_ENST00000334010_ENST00000300145_122526052_58345544 length=1566nt 
 Breakpoint=761nt
ATTCAATTCCACGTGTTGCTTGTTGTAGGCGCCACAGGTTCCCCACCTGCGTCCGGGCGCTCGGGCGGCTCCGCCTCTGCCGGCGGGCTCTGGGGAACCGCTGGGTCGGCGCGCCCGGGGCTGGCGGAGCAATTCCTGAGGCGCCCAAGC
TCACCCCCAACGCTAACTCCGCCTATTCAGTCCCGGCGGCTCCCCCTCTCCCCCCTCCCAATCCTCCTCCCGGCTCCTGCCCGCCCCTTTCGCCCTGGTGGTAGGAAACACTCCTGAATCTAACTCGACGTGTCCGGAAAGCCCTGGCCA
GTTTTCCTTTCGTTCTGCGGCCGCTGCAGCCAGCCCCGCGGCTCCCTCAGACCCGCGGGCGCAGCCGCCGGGGGTGAGGCGCTTGGGGACCGCGGGCCGAGCGGCGGGGATCCCCGAGCACCATGCTGGACCCGTCTTCCAGCGAAGAGG
AGTCGGACGAGGGGCTGGAAGAGGAAAGCCGCGATGTGCTGGTGGCAGCCGGCAGCTCGCAGCGAGCTCCTCCAGCCCCGACTCGGGAAGGGCGGCGGGACGCGCCGGGGCGCGCGGGCGGCGGCGGCGCGGCCAGATCTGTGAGCCCGA
GCCCCTCTGTGCTCAGCGAGGGGCGAGACGAGCCCCAGCGGCAGCTGGACGATGAGCAGGAGCGGAGGATCCGCCTGCAGCTCTACGTCTTCGTCGTGAGGTGCATCGCGTACCCCTTCAACGCCAAGCAGCCCACCGACATGGCCCGGA
GGCAGCAGAAGATAGTTTTGTGCCAGAATAATATCCATAATCAGGCCCATATGAACAGAGTGGTCACACACGAGCTTATTCATGCATTTGATCATTGTCGTGCCCATGTCGACTGGTTCACCAACATCAGACATTTGGCGTGCTCAGAGG
TTCGAGCTGCTAACCTTAGTGGAGACTGCTCACTTGTCAATGAAATATTCAGGTTACATTTTGGATTAAAACAACACCACCAGACTTGTGTGCGAGACAGAGCCACTCTTTCTATCCTGGCTGTTAGGAATATCAGCAAAGAAGTAGCTA
AAAAGGCTGTTGATGAAGTTTTTGAATCTTGTTTCAATGACCATGAACCTTTTGGAAGGATCCCACATAACAAGACTTATGCAAGATATGCTCACAGAGACTTTGAAAACCGTGATCGGTATTATTCAAATATATGAGCACAATGACATT
TTTATATTACAGAGCTTCCATCATCATGAAGAAAAAAAAATTTGGTTCTCAAGTGAACAAACATATAAAATGTAAACAATCCCTACAATCCAGATAAAACAGAGAAGACTGTGATTCTAGCATATTATCAGAAAAAGTAACTATGGCAAA
AAATGAAACTGCTTTAAACTCCAAGGCAGAAATTGTATCTTTATAGCTAACCATTTAGTAAATAAATACATTACATTTTTGTATTTTAGTCATTTGTTTTTATTACATGTGATTATTTTAAAATTTGATTATGAAACCTGTGAAGTGTGC
TCTTCCATGATGTTGATAGGTGACCACTGTTGGTATTTACATTAAATGTAAAGAAATGTGTACTGA

>CADPS2_XRCC6BP1_ENST00000412584_ENST00000300145_122526052_58345544 length=1265nt 
 Breakpoint=460nt
TTTTCCTTTCGTTCTGCGGCCGCTGCAGCCAGCCCCGCGGCTCCCTCAGACCCGCGGGCGCAGCCGCCGGGGGTGAGGCGCTTGGGGACCGCGGGCCGAGCGGCGGGGATCCCCGAGCACCATGCTGGACCCGTCTTCCAGCGAAGAGGA
GTCGGACGAGGGGCTGGAAGAGGAAAGCCGCGATGTGCTGGTGGCAGCCGGCAGCTCGCAGCGAGCTCCTCCAGCCCCGACTCGGGAAGGGCGGCGGGACGCGCCGGGGCGCGCGGGCGGCGGCGGCGCGGCCAGATCTGTGAGCCCGAG
CCCCTCTGTGCTCAGCGAGGGGCGAGACGAGCCCCAGCGGCAGCTGGACGATGAGCAGGAGCGGAGGATCCGCCTGCAGCTCTACGTCTTCGTCGTGAGGTGCATCGCGTACCCCTTCAACGCCAAGCAGCCCACCGACATGGCCCGGAG
GCAGCAGAAGATAGTTTTGTGCCAGAATAATATCCATAATCAGGCCCATATGAACAGAGTGGTCACACACGAGCTTATTCATGCATTTGATCATTGTCGTGCCCATGTCGACTGGTTCACCAACATCAGACATTTGGCGTGCTCAGAGGT
TCGAGCTGCTAACCTTAGTGGAGACTGCTCACTTGTCAATGAAATATTCAGGTTACATTTTGGATTAAAACAACACCACCAGACTTGTGTGCGAGACAGAGCCACTCTTTCTATCCTGGCTGTTAGGAATATCAGCAAAGAAGTAGCTAA
AAAGGCTGTTGATGAAGTTTTTGAATCTTGTTTCAATGACCATGAACCTTTTGGAAGGATCCCACATAACAAGACTTATGCAAGATATGCTCACAGAGACTTTGAAAACCGTGATCGGTATTATTCAAATATATGAGCACAATGACATTT
TTATATTACAGAGCTTCCATCATCATGAAGAAAAAAAAATTTGGTTCTCAAGTGAACAAACATATAAAATGTAAACAATCCCTACAATCCAGATAAAACAGAGAAGACTGTGATTCTAGCATATTATCAGAAAAAGTAACTATGGCAAAA
AATGAAACTGCTTTAAACTCCAAGGCAGAAATTGTATCTTTATAGCTAACCATTTAGTAAATAAATACATTACATTTTTGTATTTTAGTCATTTGTTTTTATTACATGTGATTATTTTAAAATTTGATTATGAAACCTGTGAAGTGTGCT
CTTCCATGATGTTGATAGGTGACCACTGTTGGTATTTACATTAAATGTAAAGAAATGTGTACTGA

>CADPS2_XRCC6BP1_ENST00000449022_ENST00000300145_122526052_58345544 length=1164nt 
 Breakpoint=359nt
GGCGGGGATCCCCGAGCACCATGCTGGACCCGTCTTCCAGCGAAGAGGAGTCGGACGAGGGGCTGGAAGAGGAAAGCCGCGATGTGCTGGTGGCAGCCGGCAGCTCGCAGCGAGCTCCTCCAGCCCCGACTCGGGAAGGGCGGCGGGACG
CGCCGGGGCGCGCGGGCGGCGGCGGCGCGGCCAGATCTGTGAGCCCGAGCCCCTCTGTGCTCAGCGAGGGGCGAGACGAGCCCCAGCGGCAGCTGGACGATGAGCAGGAGCGGAGGATCCGCCTGCAGCTCTACGTCTTCGTCGTGAGGT
GCATCGCGTACCCCTTCAACGCCAAGCAGCCCACCGACATGGCCCGGAGGCAGCAGAAGATAGTTTTGTGCCAGAATAATATCCATAATCAGGCCCATATGAACAGAGTGGTCACACACGAGCTTATTCATGCATTTGATCATTGTCGTG
CCCATGTCGACTGGTTCACCAACATCAGACATTTGGCGTGCTCAGAGGTTCGAGCTGCTAACCTTAGTGGAGACTGCTCACTTGTCAATGAAATATTCAGGTTACATTTTGGATTAAAACAACACCACCAGACTTGTGTGCGAGACAGAG
CCACTCTTTCTATCCTGGCTGTTAGGAATATCAGCAAAGAAGTAGCTAAAAAGGCTGTTGATGAAGTTTTTGAATCTTGTTTCAATGACCATGAACCTTTTGGAAGGATCCCACATAACAAGACTTATGCAAGATATGCTCACAGAGACT
TTGAAAACCGTGATCGGTATTATTCAAATATATGAGCACAATGACATTTTTATATTACAGAGCTTCCATCATCATGAAGAAAAAAAAATTTGGTTCTCAAGTGAACAAACATATAAAATGTAAACAATCCCTACAATCCAGATAAAACAG
AGAAGACTGTGATTCTAGCATATTATCAGAAAAAGTAACTATGGCAAAAAATGAAACTGCTTTAAACTCCAAGGCAGAAATTGTATCTTTATAGCTAACCATTTAGTAAATAAATACATTACATTTTTGTATTTTAGTCATTTGTTTTTA
TTACATGTGATTATTTTAAAATTTGATTATGAAACCTGTGAAGTGTGCTCTTCCATGATGTTGATAGGTGACCACTGTTGGTATTTACATTAAATGTAAAGAAATGTGTACTGA

N-Truncated Transcript (5UTR-3CDS) Sequences

C-Truncated Transcript (5CDS-3UTR) Sequences

>CADPS2_XRCC6BP1_ENST00000313070_ENST00000546709_122526052_58345544 length=761nt 
 Breakpoint=761nt
ATTCAATTCCACGTGTTGCTTGTTGTAGGCGCCACAGGTTCCCCACCTGCGTCCGGGCGCTCGGGCGGCTCCGCCTCTGCCGGCGGGCTCTGGGGAACCGCTGGGTCGGCGCGCCCGGGGCTGGCGGAGCAATTCCTGAGGCGCCCAAGC
TCACCCCCAACGCTAACTCCGCCTATTCAGTCCCGGCGGCTCCCCCTCTCCCCCCTCCCAATCCTCCTCCCGGCTCCTGCCCGCCCCTTTCGCCCTGGTGGTAGGAAACACTCCTGAATCTAACTCGACGTGTCCGGAAAGCCCTGGCCA
GTTTTCCTTTCGTTCTGCGGCCGCTGCAGCCAGCCCCGCGGCTCCCTCAGACCCGCGGGCGCAGCCGCCGGGGGTGAGGCGCTTGGGGACCGCGGGCCGAGCGGCGGGGATCCCCGAGCACCATGCTGGACCCGTCTTCCAGCGAAGAGG
AGTCGGACGAGGGGCTGGAAGAGGAAAGCCGCGATGTGCTGGTGGCAGCCGGCAGCTCGCAGCGAGCTCCTCCAGCCCCGACTCGGGAAGGGCGGCGGGACGCGCCGGGGCGCGCGGGCGGCGGCGGCGCGGCCAGATCTGTGAGCCCGA
GCCCCTCTGTGCTCAGCGAGGGGCGAGACGAGCCCCAGCGGCAGCTGGACGATGAGCAGGAGCGGAGGATCCGCCTGCAGCTCTACGTCTTCGTCGTGAGGTGCATCGCGTACCCCTTCAACGCCAAGCAGCCCACCGACATGGCCCGGA
GGCAGCAGAAG

>CADPS2_XRCC6BP1_ENST00000334010_ENST00000546709_122526052_58345544 length=761nt 
 Breakpoint=761nt
ATTCAATTCCACGTGTTGCTTGTTGTAGGCGCCACAGGTTCCCCACCTGCGTCCGGGCGCTCGGGCGGCTCCGCCTCTGCCGGCGGGCTCTGGGGAACCGCTGGGTCGGCGCGCCCGGGGCTGGCGGAGCAATTCCTGAGGCGCCCAAGC
TCACCCCCAACGCTAACTCCGCCTATTCAGTCCCGGCGGCTCCCCCTCTCCCCCCTCCCAATCCTCCTCCCGGCTCCTGCCCGCCCCTTTCGCCCTGGTGGTAGGAAACACTCCTGAATCTAACTCGACGTGTCCGGAAAGCCCTGGCCA
GTTTTCCTTTCGTTCTGCGGCCGCTGCAGCCAGCCCCGCGGCTCCCTCAGACCCGCGGGCGCAGCCGCCGGGGGTGAGGCGCTTGGGGACCGCGGGCCGAGCGGCGGGGATCCCCGAGCACCATGCTGGACCCGTCTTCCAGCGAAGAGG
AGTCGGACGAGGGGCTGGAAGAGGAAAGCCGCGATGTGCTGGTGGCAGCCGGCAGCTCGCAGCGAGCTCCTCCAGCCCCGACTCGGGAAGGGCGGCGGGACGCGCCGGGGCGCGCGGGCGGCGGCGGCGCGGCCAGATCTGTGAGCCCGA
GCCCCTCTGTGCTCAGCGAGGGGCGAGACGAGCCCCAGCGGCAGCTGGACGATGAGCAGGAGCGGAGGATCCGCCTGCAGCTCTACGTCTTCGTCGTGAGGTGCATCGCGTACCCCTTCAACGCCAAGCAGCCCACCGACATGGCCCGGA
GGCAGCAGAAG

>CADPS2_XRCC6BP1_ENST00000412584_ENST00000546709_122526052_58345544 length=460nt 
 Breakpoint=460nt
TTTTCCTTTCGTTCTGCGGCCGCTGCAGCCAGCCCCGCGGCTCCCTCAGACCCGCGGGCGCAGCCGCCGGGGGTGAGGCGCTTGGGGACCGCGGGCCGAGCGGCGGGGATCCCCGAGCACCATGCTGGACCCGTCTTCCAGCGAAGAGGA
GTCGGACGAGGGGCTGGAAGAGGAAAGCCGCGATGTGCTGGTGGCAGCCGGCAGCTCGCAGCGAGCTCCTCCAGCCCCGACTCGGGAAGGGCGGCGGGACGCGCCGGGGCGCGCGGGCGGCGGCGGCGCGGCCAGATCTGTGAGCCCGAG
CCCCTCTGTGCTCAGCGAGGGGCGAGACGAGCCCCAGCGGCAGCTGGACGATGAGCAGGAGCGGAGGATCCGCCTGCAGCTCTACGTCTTCGTCGTGAGGTGCATCGCGTACCCCTTCAACGCCAAGCAGCCCACCGACATGGCCCGGAG
GCAGCAGAAG

>CADPS2_XRCC6BP1_ENST00000449022_ENST00000546709_122526052_58345544 length=359nt 
 Breakpoint=359nt
GGCGGGGATCCCCGAGCACCATGCTGGACCCGTCTTCCAGCGAAGAGGAGTCGGACGAGGGGCTGGAAGAGGAAAGCCGCGATGTGCTGGTGGCAGCCGGCAGCTCGCAGCGAGCTCCTCCAGCCCCGACTCGGGAAGGGCGGCGGGACG
CGCCGGGGCGCGCGGGCGGCGGCGGCGCGGCCAGATCTGTGAGCCCGAGCCCCTCTGTGCTCAGCGAGGGGCGAGACGAGCCCCAGCGGCAGCTGGACGATGAGCAGGAGCGGAGGATCCGCCTGCAGCTCTACGTCTTCGTCGTGAGGT
GCATCGCGTACCCCTTCAACGCCAAGCAGCCCACCGACATGGCCCGGAGGCAGCAGAAG

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Fusion Protein Sequence for CADPS2_XRCC6BP1

In-frame Fusion Protein Sequences.

>CADPS2_XRCC6BP1_ENST00000313070_ENST00000300145_122526052_58345544 length=569nt
MLDPSSSEEESDEGLEEESRDVLVAAGSSQRAPPAPTREGRRDAPGRAGGGGAARSVSPSPSVLSEGRDEPQRQLDDEQERRIRLQLYVFVVRCIAYPFNAKQPTDMARRQQKVAEDKEESEEELIFTESNSEVSEEVYTEEEEEESQEE
EEEEDSDEEERTIETAKGINGTVNYDSVNSDNSKPKIFKSQIENINLTNGSNGRNTESPAAIHPCGNPTVIEDALDKIKSNDPDTTEVNLNNIENITTQTLTRFAEALKDNTVVKTFSLANTHADDSAAMAIAEMLKVNEHITNVNVESN
FITGKGILAIMRALQHNTVLTELRFHNQRHIMGSQVEMEIVKLLKENTTLLRLGYHFELPGPRMSMTSILTRNMDKQRQKRLQEQKQQEGYDGGPNLRTKVWQRGTPSSSPYVSPRHSPWSSPKLPKKVQTVRSRPLSPVATPPPPPPPP
PPPPPSSQRLPPPPPPPPPPLPEKKLITRNIAEVIKQQESAQRALQNGQKKKKGKKVKKQPNSILKEIKNSLRSVQEKKMEDSSRPSTPQRSAHENLMEAIRGSSIKQLKRVEVPEALR

>CADPS2_XRCC6BP1_ENST00000334010_ENST00000300145_122526052_58345544 length=254nt
MLDPSSSEEESDEGLEEESRDVLVAAGSSQRAPPAPTREGRRDAPGRAGGGGAARSVSPSPSVLSEGRDEPQRQLDDEQERRIRLQLYVFVVRCIAYPFNAKQPTDMARRQQKIVLCQNNIHNQAHMNRVVTHELIHAFDHCRAHVDWFT
NIRHLACSEVRAANLSGDCSLVNEIFRLHFGLKQHHQTCVRDRATLSILAVRNISKEVAKKAVDEVFESCFNDHEPFGRIPHNKTYARYAHRDFENRDRYYSNI

>CADPS2_XRCC6BP1_ENST00000412584_ENST00000300145_122526052_58345544 length=254nt
MLDPSSSEEESDEGLEEESRDVLVAAGSSQRAPPAPTREGRRDAPGRAGGGGAARSVSPSPSVLSEGRDEPQRQLDDEQERRIRLQLYVFVVRCIAYPFNAKQPTDMARRQQKIVLCQNNIHNQAHMNRVVTHELIHAFDHCRAHVDWFT
NIRHLACSEVRAANLSGDCSLVNEIFRLHFGLKQHHQTCVRDRATLSILAVRNISKEVAKKAVDEVFESCFNDHEPFGRIPHNKTYARYAHRDFENRDRYYSNI

>CADPS2_XRCC6BP1_ENST00000449022_ENST00000300145_122526052_58345544 length=254nt
MLDPSSSEEESDEGLEEESRDVLVAAGSSQRAPPAPTREGRRDAPGRAGGGGAARSVSPSPSVLSEGRDEPQRQLDDEQERRIRLQLYVFVVRCIAYPFNAKQPTDMARRQQKIVLCQNNIHNQAHMNRVVTHELIHAFDHCRAHVDWFT
NIRHLACSEVRAANLSGDCSLVNEIFRLHFGLKQHHQTCVRDRATLSILAVRNISKEVAKKAVDEVFESCFNDHEPFGRIPHNKTYARYAHRDFENRDRYYSNI

N-Truncated Protein (5UTR-3CDS) Sequences

C-Truncated Protein (5CDS-3UTR) Sequences

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Personalized Fusion Protein Sequence for CADPS2_XRCC6BP1

TCGA Kinase/DNA-binding Domain Mutated Fusion Protein Sequences

Num

Gene Group

Domain Loci

Fusion Protein ID

Fusion Gene Name

Partner

Mutated Residue in WT Protein

Seq. Length

Mutated Residue in Fusion Protein

CCLE Kinase/DNA-binding Domain Mutated Fusion Protein Sequences

Num

Gene Group

Domain Loci

Fusion Protein ID

Fusion Gene Name

Partner

Mutated Residue in WT Protein

Seq. Length

Mutated Residue in Fusion Protein

TCGA All Mutated Fusion Protein Sequences

>CADPS2_XRCC6BP1_ENST00000313070_ENST00000300145_122526052_58345544_5-gene_p.E80Q_569_E80Q length=569AA
MLDPSSSEEESDEGLEEESRDVLVAAGSSQRAPPAPTREGRRDAPGRAGGGGAARSVSPSPSVLSEGRDEPQRQLDDEQQRRIRLQLYVFVVRCIAYPFNAKQPTDMARRQQKVAEDKEESEEELIFTESNSEVSEEVYTEEEEEESQEE
EEEEDSDEEERTIETAKGINGTVNYDSVNSDNSKPKIFKSQIENINLTNGSNGRNTESPAAIHPCGNPTVIEDALDKIKSNDPDTTEVNLNNIENITTQTLTRFAEALKDNTVVKTFSLANTHADDSAAMAIAEMLKVNEHITNVNVESN
FITGKGILAIMRALQHNTVLTELRFHNQRHIMGSQVEMEIVKLLKENTTLLRLGYHFELPGPRMSMTSILTRNMDKQRQKRLQEQKQQEGYDGGPNLRTKVWQRGTPSSSPYVSPRHSPWSSPKLPKKVQTVRSRPLSPVATPPPPPPPP
PPPPPSSQRLPPPPPPPPPPLPEKKLITRNIAEVIKQQESAQRALQNGQKKKKGKKVKKQPNSILKEIKNSLRSVQEKKMEDSSRPSTPQRSAHENLMEAIRGSSIKQLKRVEVPEALR

>CADPS2_XRCC6BP1_ENST00000313070_ENST00000300145_122526052_58345544_5-gene_p.F99S_569_F99S length=569AA
MLDPSSSEEESDEGLEEESRDVLVAAGSSQRAPPAPTREGRRDAPGRAGGGGAARSVSPSPSVLSEGRDEPQRQLDDEQERRIRLQLYVFVVRCIAYPSNAKQPTDMARRQQKVAEDKEESEEELIFTESNSEVSEEVYTEEEEEESQEE
EEEEDSDEEERTIETAKGINGTVNYDSVNSDNSKPKIFKSQIENINLTNGSNGRNTESPAAIHPCGNPTVIEDALDKIKSNDPDTTEVNLNNIENITTQTLTRFAEALKDNTVVKTFSLANTHADDSAAMAIAEMLKVNEHITNVNVESN
FITGKGILAIMRALQHNTVLTELRFHNQRHIMGSQVEMEIVKLLKENTTLLRLGYHFELPGPRMSMTSILTRNMDKQRQKRLQEQKQQEGYDGGPNLRTKVWQRGTPSSSPYVSPRHSPWSSPKLPKKVQTVRSRPLSPVATPPPPPPPP
PPPPPSSQRLPPPPPPPPPPLPEKKLITRNIAEVIKQQESAQRALQNGQKKKKGKKVKKQPNSILKEIKNSLRSVQEKKMEDSSRPSTPQRSAHENLMEAIRGSSIKQLKRVEVPEALR

>CADPS2_XRCC6BP1_ENST00000313070_ENST00000300145_122526052_58345544_5-gene_p.R47S_569_R47S length=569AA
MLDPSSSEEESDEGLEEESRDVLVAAGSSQRAPPAPTREGRRDAPGSAGGGGAARSVSPSPSVLSEGRDEPQRQLDDEQERRIRLQLYVFVVRCIAYPFNAKQPTDMARRQQKVAEDKEESEEELIFTESNSEVSEEVYTEEEEEESQEE
EEEEDSDEEERTIETAKGINGTVNYDSVNSDNSKPKIFKSQIENINLTNGSNGRNTESPAAIHPCGNPTVIEDALDKIKSNDPDTTEVNLNNIENITTQTLTRFAEALKDNTVVKTFSLANTHADDSAAMAIAEMLKVNEHITNVNVESN
FITGKGILAIMRALQHNTVLTELRFHNQRHIMGSQVEMEIVKLLKENTTLLRLGYHFELPGPRMSMTSILTRNMDKQRQKRLQEQKQQEGYDGGPNLRTKVWQRGTPSSSPYVSPRHSPWSSPKLPKKVQTVRSRPLSPVATPPPPPPPP
PPPPPSSQRLPPPPPPPPPPLPEKKLITRNIAEVIKQQESAQRALQNGQKKKKGKKVKKQPNSILKEIKNSLRSVQEKKMEDSSRPSTPQRSAHENLMEAIRGSSIKQLKRVEVPEALR

>CADPS2_XRCC6BP1_ENST00000313070_ENST00000300145_122526052_58345544_5-gene_p.P104T_569_P104T length=569AA
MLDPSSSEEESDEGLEEESRDVLVAAGSSQRAPPAPTREGRRDAPGRAGGGGAARSVSPSPSVLSEGRDEPQRQLDDEQERRIRLQLYVFVVRCIAYPFNAKQTTDMARRQQKVAEDKEESEEELIFTESNSEVSEEVYTEEEEEESQEE
EEEEDSDEEERTIETAKGINGTVNYDSVNSDNSKPKIFKSQIENINLTNGSNGRNTESPAAIHPCGNPTVIEDALDKIKSNDPDTTEVNLNNIENITTQTLTRFAEALKDNTVVKTFSLANTHADDSAAMAIAEMLKVNEHITNVNVESN
FITGKGILAIMRALQHNTVLTELRFHNQRHIMGSQVEMEIVKLLKENTTLLRLGYHFELPGPRMSMTSILTRNMDKQRQKRLQEQKQQEGYDGGPNLRTKVWQRGTPSSSPYVSPRHSPWSSPKLPKKVQTVRSRPLSPVATPPPPPPPP
PPPPPSSQRLPPPPPPPPPPLPEKKLITRNIAEVIKQQESAQRALQNGQKKKKGKKVKKQPNSILKEIKNSLRSVQEKKMEDSSRPSTPQRSAHENLMEAIRGSSIKQLKRVEVPEALR

>CADPS2_XRCC6BP1_ENST00000313070_ENST00000300145_122526052_58345544_5-gene_p.G51C_569_G51C length=569AA
MLDPSSSEEESDEGLEEESRDVLVAAGSSQRAPPAPTREGRRDAPGRAGGCGAARSVSPSPSVLSEGRDEPQRQLDDEQERRIRLQLYVFVVRCIAYPFNAKQPTDMARRQQKVAEDKEESEEELIFTESNSEVSEEVYTEEEEEESQEE
EEEEDSDEEERTIETAKGINGTVNYDSVNSDNSKPKIFKSQIENINLTNGSNGRNTESPAAIHPCGNPTVIEDALDKIKSNDPDTTEVNLNNIENITTQTLTRFAEALKDNTVVKTFSLANTHADDSAAMAIAEMLKVNEHITNVNVESN
FITGKGILAIMRALQHNTVLTELRFHNQRHIMGSQVEMEIVKLLKENTTLLRLGYHFELPGPRMSMTSILTRNMDKQRQKRLQEQKQQEGYDGGPNLRTKVWQRGTPSSSPYVSPRHSPWSSPKLPKKVQTVRSRPLSPVATPPPPPPPP
PPPPPSSQRLPPPPPPPPPPLPEKKLITRNIAEVIKQQESAQRALQNGQKKKKGKKVKKQPNSILKEIKNSLRSVQEKKMEDSSRPSTPQRSAHENLMEAIRGSSIKQLKRVEVPEALR

>CADPS2_XRCC6BP1_ENST00000334010_ENST00000300145_122526052_58345544_5-gene_p.K113N_254_K113N length=254AA
MLDPSSSEEESDEGLEEESRDVLVAAGSSQRAPPAPTREGRRDAPGRAGGGGAARSVSPSPSVLSEGRDEPQRQLDDEQERRIRLQLYVFVVRCIAYPFNAKQPTDMARRQQNIVLCQNNIHNQAHMNRVVTHELIHAFDHCRAHVDWFT
NIRHLACSEVRAANLSGDCSLVNEIFRLHFGLKQHHQTCVRDRATLSILAVRNISKEVAKKAVDEVFESCFNDHEPFGRIPHNKTYARYAHRDFENRDRYYSNI

>CADPS2_XRCC6BP1_ENST00000334010_ENST00000300145_122526052_58345544_5-gene_p.E80Q_254_E80Q length=254AA
MLDPSSSEEESDEGLEEESRDVLVAAGSSQRAPPAPTREGRRDAPGRAGGGGAARSVSPSPSVLSEGRDEPQRQLDDEQQRRIRLQLYVFVVRCIAYPFNAKQPTDMARRQQKIVLCQNNIHNQAHMNRVVTHELIHAFDHCRAHVDWFT
NIRHLACSEVRAANLSGDCSLVNEIFRLHFGLKQHHQTCVRDRATLSILAVRNISKEVAKKAVDEVFESCFNDHEPFGRIPHNKTYARYAHRDFENRDRYYSNI

>CADPS2_XRCC6BP1_ENST00000334010_ENST00000300145_122526052_58345544_5-gene_p.F99S_254_F99S length=254AA
MLDPSSSEEESDEGLEEESRDVLVAAGSSQRAPPAPTREGRRDAPGRAGGGGAARSVSPSPSVLSEGRDEPQRQLDDEQERRIRLQLYVFVVRCIAYPSNAKQPTDMARRQQKIVLCQNNIHNQAHMNRVVTHELIHAFDHCRAHVDWFT
NIRHLACSEVRAANLSGDCSLVNEIFRLHFGLKQHHQTCVRDRATLSILAVRNISKEVAKKAVDEVFESCFNDHEPFGRIPHNKTYARYAHRDFENRDRYYSNI

>CADPS2_XRCC6BP1_ENST00000334010_ENST00000300145_122526052_58345544_5-gene_p.R47S_254_R47S length=254AA
MLDPSSSEEESDEGLEEESRDVLVAAGSSQRAPPAPTREGRRDAPGSAGGGGAARSVSPSPSVLSEGRDEPQRQLDDEQERRIRLQLYVFVVRCIAYPFNAKQPTDMARRQQKIVLCQNNIHNQAHMNRVVTHELIHAFDHCRAHVDWFT
NIRHLACSEVRAANLSGDCSLVNEIFRLHFGLKQHHQTCVRDRATLSILAVRNISKEVAKKAVDEVFESCFNDHEPFGRIPHNKTYARYAHRDFENRDRYYSNI

>CADPS2_XRCC6BP1_ENST00000334010_ENST00000300145_122526052_58345544_5-gene_p.P104T_254_P104T length=254AA
MLDPSSSEEESDEGLEEESRDVLVAAGSSQRAPPAPTREGRRDAPGRAGGGGAARSVSPSPSVLSEGRDEPQRQLDDEQERRIRLQLYVFVVRCIAYPFNAKQTTDMARRQQKIVLCQNNIHNQAHMNRVVTHELIHAFDHCRAHVDWFT
NIRHLACSEVRAANLSGDCSLVNEIFRLHFGLKQHHQTCVRDRATLSILAVRNISKEVAKKAVDEVFESCFNDHEPFGRIPHNKTYARYAHRDFENRDRYYSNI

>CADPS2_XRCC6BP1_ENST00000334010_ENST00000300145_122526052_58345544_5-gene_p.G51C_254_G51C length=254AA
MLDPSSSEEESDEGLEEESRDVLVAAGSSQRAPPAPTREGRRDAPGRAGGCGAARSVSPSPSVLSEGRDEPQRQLDDEQERRIRLQLYVFVVRCIAYPFNAKQPTDMARRQQKIVLCQNNIHNQAHMNRVVTHELIHAFDHCRAHVDWFT
NIRHLACSEVRAANLSGDCSLVNEIFRLHFGLKQHHQTCVRDRATLSILAVRNISKEVAKKAVDEVFESCFNDHEPFGRIPHNKTYARYAHRDFENRDRYYSNI

>CADPS2_XRCC6BP1_ENST00000412584_ENST00000300145_122526052_58345544_5-gene_p.K113N_254_K113N length=254AA
MLDPSSSEEESDEGLEEESRDVLVAAGSSQRAPPAPTREGRRDAPGRAGGGGAARSVSPSPSVLSEGRDEPQRQLDDEQERRIRLQLYVFVVRCIAYPFNAKQPTDMARRQQNIVLCQNNIHNQAHMNRVVTHELIHAFDHCRAHVDWFT
NIRHLACSEVRAANLSGDCSLVNEIFRLHFGLKQHHQTCVRDRATLSILAVRNISKEVAKKAVDEVFESCFNDHEPFGRIPHNKTYARYAHRDFENRDRYYSNI

>CADPS2_XRCC6BP1_ENST00000412584_ENST00000300145_122526052_58345544_5-gene_p.E80Q_254_E80Q length=254AA
MLDPSSSEEESDEGLEEESRDVLVAAGSSQRAPPAPTREGRRDAPGRAGGGGAARSVSPSPSVLSEGRDEPQRQLDDEQQRRIRLQLYVFVVRCIAYPFNAKQPTDMARRQQKIVLCQNNIHNQAHMNRVVTHELIHAFDHCRAHVDWFT
NIRHLACSEVRAANLSGDCSLVNEIFRLHFGLKQHHQTCVRDRATLSILAVRNISKEVAKKAVDEVFESCFNDHEPFGRIPHNKTYARYAHRDFENRDRYYSNI

>CADPS2_XRCC6BP1_ENST00000412584_ENST00000300145_122526052_58345544_5-gene_p.F99S_254_F99S length=254AA
MLDPSSSEEESDEGLEEESRDVLVAAGSSQRAPPAPTREGRRDAPGRAGGGGAARSVSPSPSVLSEGRDEPQRQLDDEQERRIRLQLYVFVVRCIAYPSNAKQPTDMARRQQKIVLCQNNIHNQAHMNRVVTHELIHAFDHCRAHVDWFT
NIRHLACSEVRAANLSGDCSLVNEIFRLHFGLKQHHQTCVRDRATLSILAVRNISKEVAKKAVDEVFESCFNDHEPFGRIPHNKTYARYAHRDFENRDRYYSNI

>CADPS2_XRCC6BP1_ENST00000412584_ENST00000300145_122526052_58345544_5-gene_p.R47S_254_R47S length=254AA
MLDPSSSEEESDEGLEEESRDVLVAAGSSQRAPPAPTREGRRDAPGSAGGGGAARSVSPSPSVLSEGRDEPQRQLDDEQERRIRLQLYVFVVRCIAYPFNAKQPTDMARRQQKIVLCQNNIHNQAHMNRVVTHELIHAFDHCRAHVDWFT
NIRHLACSEVRAANLSGDCSLVNEIFRLHFGLKQHHQTCVRDRATLSILAVRNISKEVAKKAVDEVFESCFNDHEPFGRIPHNKTYARYAHRDFENRDRYYSNI

>CADPS2_XRCC6BP1_ENST00000412584_ENST00000300145_122526052_58345544_5-gene_p.P104T_254_P104T length=254AA
MLDPSSSEEESDEGLEEESRDVLVAAGSSQRAPPAPTREGRRDAPGRAGGGGAARSVSPSPSVLSEGRDEPQRQLDDEQERRIRLQLYVFVVRCIAYPFNAKQTTDMARRQQKIVLCQNNIHNQAHMNRVVTHELIHAFDHCRAHVDWFT
NIRHLACSEVRAANLSGDCSLVNEIFRLHFGLKQHHQTCVRDRATLSILAVRNISKEVAKKAVDEVFESCFNDHEPFGRIPHNKTYARYAHRDFENRDRYYSNI

>CADPS2_XRCC6BP1_ENST00000412584_ENST00000300145_122526052_58345544_5-gene_p.G51C_254_G51C length=254AA
MLDPSSSEEESDEGLEEESRDVLVAAGSSQRAPPAPTREGRRDAPGRAGGCGAARSVSPSPSVLSEGRDEPQRQLDDEQERRIRLQLYVFVVRCIAYPFNAKQPTDMARRQQKIVLCQNNIHNQAHMNRVVTHELIHAFDHCRAHVDWFT
NIRHLACSEVRAANLSGDCSLVNEIFRLHFGLKQHHQTCVRDRATLSILAVRNISKEVAKKAVDEVFESCFNDHEPFGRIPHNKTYARYAHRDFENRDRYYSNI

>CADPS2_XRCC6BP1_ENST00000449022_ENST00000300145_122526052_58345544_5-gene_p.K113N_254_K113N length=254AA
MLDPSSSEEESDEGLEEESRDVLVAAGSSQRAPPAPTREGRRDAPGRAGGGGAARSVSPSPSVLSEGRDEPQRQLDDEQERRIRLQLYVFVVRCIAYPFNAKQPTDMARRQQNIVLCQNNIHNQAHMNRVVTHELIHAFDHCRAHVDWFT
NIRHLACSEVRAANLSGDCSLVNEIFRLHFGLKQHHQTCVRDRATLSILAVRNISKEVAKKAVDEVFESCFNDHEPFGRIPHNKTYARYAHRDFENRDRYYSNI

>CADPS2_XRCC6BP1_ENST00000449022_ENST00000300145_122526052_58345544_5-gene_p.E80Q_254_E80Q length=254AA
MLDPSSSEEESDEGLEEESRDVLVAAGSSQRAPPAPTREGRRDAPGRAGGGGAARSVSPSPSVLSEGRDEPQRQLDDEQQRRIRLQLYVFVVRCIAYPFNAKQPTDMARRQQKIVLCQNNIHNQAHMNRVVTHELIHAFDHCRAHVDWFT
NIRHLACSEVRAANLSGDCSLVNEIFRLHFGLKQHHQTCVRDRATLSILAVRNISKEVAKKAVDEVFESCFNDHEPFGRIPHNKTYARYAHRDFENRDRYYSNI

>CADPS2_XRCC6BP1_ENST00000449022_ENST00000300145_122526052_58345544_5-gene_p.F99S_254_F99S length=254AA
MLDPSSSEEESDEGLEEESRDVLVAAGSSQRAPPAPTREGRRDAPGRAGGGGAARSVSPSPSVLSEGRDEPQRQLDDEQERRIRLQLYVFVVRCIAYPSNAKQPTDMARRQQKIVLCQNNIHNQAHMNRVVTHELIHAFDHCRAHVDWFT
NIRHLACSEVRAANLSGDCSLVNEIFRLHFGLKQHHQTCVRDRATLSILAVRNISKEVAKKAVDEVFESCFNDHEPFGRIPHNKTYARYAHRDFENRDRYYSNI

>CADPS2_XRCC6BP1_ENST00000449022_ENST00000300145_122526052_58345544_5-gene_p.R47S_254_R47S length=254AA
MLDPSSSEEESDEGLEEESRDVLVAAGSSQRAPPAPTREGRRDAPGSAGGGGAARSVSPSPSVLSEGRDEPQRQLDDEQERRIRLQLYVFVVRCIAYPFNAKQPTDMARRQQKIVLCQNNIHNQAHMNRVVTHELIHAFDHCRAHVDWFT
NIRHLACSEVRAANLSGDCSLVNEIFRLHFGLKQHHQTCVRDRATLSILAVRNISKEVAKKAVDEVFESCFNDHEPFGRIPHNKTYARYAHRDFENRDRYYSNI

>CADPS2_XRCC6BP1_ENST00000449022_ENST00000300145_122526052_58345544_5-gene_p.P104T_254_P104T length=254AA
MLDPSSSEEESDEGLEEESRDVLVAAGSSQRAPPAPTREGRRDAPGRAGGGGAARSVSPSPSVLSEGRDEPQRQLDDEQERRIRLQLYVFVVRCIAYPFNAKQTTDMARRQQKIVLCQNNIHNQAHMNRVVTHELIHAFDHCRAHVDWFT
NIRHLACSEVRAANLSGDCSLVNEIFRLHFGLKQHHQTCVRDRATLSILAVRNISKEVAKKAVDEVFESCFNDHEPFGRIPHNKTYARYAHRDFENRDRYYSNI

>CADPS2_XRCC6BP1_ENST00000449022_ENST00000300145_122526052_58345544_5-gene_p.G51C_254_G51C length=254AA
MLDPSSSEEESDEGLEEESRDVLVAAGSSQRAPPAPTREGRRDAPGRAGGCGAARSVSPSPSVLSEGRDEPQRQLDDEQERRIRLQLYVFVVRCIAYPFNAKQPTDMARRQQKIVLCQNNIHNQAHMNRVVTHELIHAFDHCRAHVDWFT
NIRHLACSEVRAANLSGDCSLVNEIFRLHFGLKQHHQTCVRDRATLSILAVRNISKEVAKKAVDEVFESCFNDHEPFGRIPHNKTYARYAHRDFENRDRYYSNI

Fusion Protein ID	Sample ID	Mutated Partner	AAchange in WT	Seq. Length	AAchange in Fusion
ENST00000313070_ENST00000300145_122526052_58345544	TCGA-DD-A4NI-01A	5-gene	p.E80Q	569	E80Q
ENST00000313070_ENST00000300145_122526052_58345544	TCGA-DU-6392-01A	5-gene	p.F99S	569	F99S
ENST00000313070_ENST00000300145_122526052_58345544	TCGA-DX-A6BF-01A	5-gene	p.R47S	569	R47S
ENST00000313070_ENST00000300145_122526052_58345544	TCGA-G4-6304-01A	5-gene	p.P104T	569	P104T
ENST00000313070_ENST00000300145_122526052_58345544	TCGA-MI-A75G-01A	5-gene	p.G51C	569	G51C
ENST00000334010_ENST00000300145_122526052_58345544	TCGA-AA-3984-01A	5-gene	p.K113N	254	K113N
ENST00000334010_ENST00000300145_122526052_58345544	TCGA-DD-A4NI-01A	5-gene	p.E80Q	254	E80Q
ENST00000334010_ENST00000300145_122526052_58345544	TCGA-DU-6392-01A	5-gene	p.F99S	254	F99S
ENST00000334010_ENST00000300145_122526052_58345544	TCGA-DX-A6BF-01A	5-gene	p.R47S	254	R47S
ENST00000334010_ENST00000300145_122526052_58345544	TCGA-G4-6304-01A	5-gene	p.P104T	254	P104T
ENST00000334010_ENST00000300145_122526052_58345544	TCGA-MI-A75G-01A	5-gene	p.G51C	254	G51C
ENST00000412584_ENST00000300145_122526052_58345544	TCGA-AA-3984-01A	5-gene	p.K113N	254	K113N
ENST00000412584_ENST00000300145_122526052_58345544	TCGA-DD-A4NI-01A	5-gene	p.E80Q	254	E80Q
ENST00000412584_ENST00000300145_122526052_58345544	TCGA-DU-6392-01A	5-gene	p.F99S	254	F99S
ENST00000412584_ENST00000300145_122526052_58345544	TCGA-DX-A6BF-01A	5-gene	p.R47S	254	R47S
ENST00000412584_ENST00000300145_122526052_58345544	TCGA-G4-6304-01A	5-gene	p.P104T	254	P104T
ENST00000412584_ENST00000300145_122526052_58345544	TCGA-MI-A75G-01A	5-gene	p.G51C	254	G51C
ENST00000449022_ENST00000300145_122526052_58345544	TCGA-AA-3984-01A	5-gene	p.K113N	254	K113N
ENST00000449022_ENST00000300145_122526052_58345544	TCGA-DD-A4NI-01A	5-gene	p.E80Q	254	E80Q
ENST00000449022_ENST00000300145_122526052_58345544	TCGA-DU-6392-01A	5-gene	p.F99S	254	F99S
ENST00000449022_ENST00000300145_122526052_58345544	TCGA-DX-A6BF-01A	5-gene	p.R47S	254	R47S
ENST00000449022_ENST00000300145_122526052_58345544	TCGA-G4-6304-01A	5-gene	p.P104T	254	P104T
ENST00000449022_ENST00000300145_122526052_58345544	TCGA-MI-A75G-01A	5-gene	p.G51C	254	G51C

CCLE All Mutated Fusion Protein Sequences

Fusion Protein ID

Sample ID

Mutated Partner

AAchange in WT

Seq. Length

AAchange in Fusion

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Fusion Gene Exprssed Samples for CADPS2_XRCC6BP1

RNA-seq based fusion gene expressed samples.

Source	Study	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB		SARC	TCGA-DX-A6BH-01A	CADPS2	chr7	122526053	-	ATP23	chr12	58345541	+
WashU		SARC	TCGA-DX-A6BH-01A	CADPS2	chr7	122526053	-	ATP23	chr12	58345541	+
cBioPortal	SARC_TCGA_PAN_CAN_ATLAS_2018	SOFT_TISSUE	TCGA-DX-A6BH-01	CADPS2	chr7	122885999		ATP23	chr12	57951758
ChimerDB		SARC	TCGA-DX-A6BH-01A	CADPS2	chr7	122525447	-	XRCC6BP1	chr12	0	+
ChimerDB		SARC	TCGA-DX-A6BH-01A	CADPS2	chr7	122526052	-	XRCC6BP1	chr12	122526052	+
ChimerDB		SARC	TCGA-DX-A6BH-01A	CADPS2	chr7	122526052	-	XRCC6BP1	chr12	58345540	+
ChimerDB		SARC	TCGA-DX-A6BH	CADPS2	chr7	122526052	-	XRCC6BP1	chr12	122526052	+

DNA-seq based fusion gene expressed samples.

Source

Study

Disease

Sample

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

SV type

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Related Drugs for CADPS2_XRCC6BP1

PubMed Abstract Search With ['A-B' AND 'drug'], ['A::B' AND 'drug']
* For more details on the Studied, Reported, Approved Drugs targeting this fusion gene, Go to FusionPub.

PMID

Fusion Gene Name

Drug

Study Title

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status