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	Fusion Gene Summary
	Fusion Gene Breakpoints
	Tumorigenic MoA (Mechanism of Action) Scenarios of Fusion Geness
	Fusion Genomic Features
	Fusion Gene ORF Annotations
	Fusion Protein Retained/Non-Retained Functional Features
	Fusion Transcript Sequences
	Fusion Protein Sequences
	Personalized Fusion Protein Sequences
	Fusion Gene Expressed Samples
	Related Drugs

Fusion gene:ROCK2_MEIS1 (FusionGDB2 ID:HG9475TG4211)

Fusion Gene Summary for ROCK2_MEIS1

Fusion gene summary

Fusion gene information	Fusion gene name: ROCK2_MEIS1
	Fusion gene ID: hg9475tg4211
		Hgene	Tgene
	Gene symbol	ROCK2	MEIS1
	Gene ID	9475	4211
	Gene name	Rho associated coiled-coil containing protein kinase 2	Meis homeobox 1
	Synonyms	ROCK-II	-
	Cytomap	2p25.1	2p14
	Type of gene	protein-coding	protein-coding
	Description	rho-associated protein kinase 2p164 ROCK-2rho-associated, coiled-coil-containing protein kinase II	homeobox protein Meis1Meis1, myeloid ecotropic viral integration site 1 homologWUGSC:H_NH0444B04.1leukemogenic homolog protein
	Modification date	20240403	20240411
	UniProtAcc	.	O00470
	Ensembl transtripts involved in fusion gene	ENST00000315872, ENST00000401753, ENST00000462366,
Fusion gene scores	* DoF score	* DoF score (Degree of Frequency) = # partners X # break points X # disease types 27 X 18 X 20=9720	* DoF score (Degree of Frequency) = # partners X # break points X # disease types 3 X 7 X 4=84
	# samples	45	7
	** MAII score	** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score10) log2(45/972010)=-4.43295940727611 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score10) log2(7/8410)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: ROCK2 [Title/Abstract] AND MEIS1 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	ROCK2(11484121)-MEIS1(66775074), # samples:1

Fusion gene breakpoints across ROCK2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across MEIS1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Breakpoints for ROCK2_MEIS1

RNA-seq based exon junction arranged fusion gene breakpoints from 8 resources (TCGA, CCLE, cBioPortal, GenBank, ChimerDB, ChimerKB, ChildHoodFusions, and GTEx). For the expressed sample information, go to Fusion Gene Sample section.

Hgene	Hchr	Hbp	Tgene	Tchr	Tbp
ROCK2	chr2	11484121	MEIS1	chr2	11484121
ROCK2	chr2	11484122	MEIS1	chr2	66775075

DNA-seq based exon junction arranged fusion gene breakpoints from dbVar. For the expressed sample information, go to Fusion Gene Sample section.

Hgene

Hchr

Hbp

Tgene

Tchr

Tbp

SV type

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Tumorigenic MoA (Mechanism of Action) Scenarios of Fusion Genes for ROCK2_MEIS1

To generate these tumorigenic scenario annotations, we implemented a deduction-first, retrieval-later computational framework. The pipeline first applies rule-guided reasoning across ten core mechanistic categories (M1–M10) derived from fusion gene biology to infer candidate mechanisms, tumorigenic scenarios, targeting points, and targeting backgrounds. To ensure empirical accountability, a governed Python workflow retrieves literature candidates via NCBI E-utilities and Europe PMC using tiered searches. Using JSON Schema-constrained LLM evidence judges (GPT-5.6 Luna and Terra), retrieved articles are evaluated for specificity and confidence without de novo PMID generation. This produces two distinct versions: a strict version restricted to high- or medium-confidence fusion-specific evidence, and an extended version incorporating broader gene-, pathway-, and contextual evidence.

* We have 10 tumorigenic mechanism categories of fusion genes as shown below.

Constitutively Active Kinases, Catalytic Domain Dysregulation, & Transmembrane Ligand Fusions	Aberrant Chimeric Transcription Factor / Fusion Transcription Factor Activity	Epigenetic Reprogramming / Histone Modifier Dysregulation	Chromatin Remodeling Dysregulation	Condensate-Driven Transcriptional Rewiring / LLP	Promoter / Enhancer Hijacking	Dominant-Negative Antagonism	Cell Cycle / Checkpoint Bypass / RNA Processing Dysregulation	Subcellular Mislocalization / Spatial Dysregulation	Nuclear Body / Sub-organellar Architecture Disruption & Differentiation Blockade

* Strict version: Restricted to high- or medium-confidence fusion-specific evidence.

Fusion Gene Name	Mechanism Category	Mechanism PubMed	Tumorigenic Scenarios	Tumorigenic Scenario PubMed	Targeting Points	Targeting PubMed	Mechanism Background	Mechanism Background PubMed
ROCK2-MEIS1	Constitutively Active Kinases, Catalytic Domain Dysregulation, & Transmembrane Ligand Fusions M1		ROCK2 kinase domain couples to MEIS1 homeobox transcription factor, coordinating Rho-mediated cytoskeletal contraction with aberrant myeloid/growth transactivation.		ROCK inhibitors; transcriptional CDK inhibitors		Acute leukemia and invasive carcinomas

* Extended version: Includes all strict-level fusion evidence plus broader gene-, pathway-, and low-confidence contextual evidence.

Fusion Gene Name	Mechanism Category	Mechanism PubMed	Tumorigenic Scenarios	Tumorigenic Scenario PubMed	Targeting Points	Targeting PubMed	Mechanism Background	Mechanism Background PubMed
ROCK2-MEIS1	Constitutively Active Kinases, Catalytic Domain Dysregulation, & Transmembrane Ligand Fusions M1	Evidence level: Indirect gene evidence; Confidence: Medium; PMID: 41595753; Title: Menin Inhibition in Acute Myeloid Leukemia: Pathobiology, Progress and Promise.	ROCK2 kinase domain couples to MEIS1 homeobox transcription factor, coordinating Rho-mediated cytoskeletal contraction with aberrant myeloid/growth transactivation.	Evidence level: Limited indirect gene evidence; Confidence: Low; PMID: 41595753; Title: Menin Inhibition in Acute Myeloid Leukemia: Pathobiology, Progress and Promise.	ROCK inhibitors; transcriptional CDK inhibitors		Acute leukemia and invasive carcinomas	Evidence level: Limited indirect gene evidence; Confidence: Low; PMID: 41595753; Title: Menin Inhibition in Acute Myeloid Leukemia: Pathobiology, Progress and Promise.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	MEIS1 O00470

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	ROCK2	GO:0006468	protein phosphorylation	18559669

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Fusion Genomic Features for ROCK2_MEIS1

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence) of In-frame fusion genes. FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
ROCK2	chr2	11484121	-	MEIS1	chr2	66775074	+	1.27e-06	1.00e+00

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence) of 5UTR-3CSD fusion genes (N-truncated cases).

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence) of 5CDS-3UTR fusion genes (C-truncated cases).

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of six genomic regulatory feature tracks across a ±5 kb window centered on the fusion breakpoints. We input the breakpoint sequences into AlphaGenome and obtained predicted genome tracks at single-base-pair resolution for each modality by running a single forward pass over the reference sequence. Specifically, for each breakpoint, AlphaGenome processed and returned predicted track data across diverse modalities, which were then averaged across all tracks within each output type and visualized across the ±5 kb window. The left panel shows the 5'-gene breakpoint ±5 kb area, and the right panel shows the 3'-gene breakpoint area, with tracks grouped by category: chromatin accessibility (DNase-seq, ATAC-seq), active transcription (RNA-seq, CAGE), and chromatin binding (ChIP-Histone, ChIP-TF).

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Fusion Gene ORF Annotations for ROCK2_MEIS1

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-3UTR	ENST00000315872	ENST00000409517	ROCK2	chr2	11484121	-	MEIS1	chr2	66775074	+
In-frame	ENST00000315872	ENST00000272369	ROCK2	chr2	11484121	-	MEIS1	chr2	66775074	+
In-frame	ENST00000315872	ENST00000398506	ROCK2	chr2	11484121	-	MEIS1	chr2	66775074	+
In-frame	ENST00000315872	ENST00000407092	ROCK2	chr2	11484121	-	MEIS1	chr2	66775074	+
In-frame	ENST00000315872	ENST00000444274	ROCK2	chr2	11484121	-	MEIS1	chr2	66775074	+
In-frame	ENST00000315872	ENST00000488550	ROCK2	chr2	11484121	-	MEIS1	chr2	66775074	+
In-frame	ENST00000315872	ENST00000495021	ROCK2	chr2	11484121	-	MEIS1	chr2	66775074	+
In-frame	ENST00000315872	ENST00000560281	ROCK2	chr2	11484121	-	MEIS1	chr2	66775074	+

ORFfinder Result Based On The Fusion Transcript Sequences of the In-frame Fusion Genes.

Henst	Tenst	Hgene	Hchr	Hbp	Tgene	Tchr	Tbp	Seq length (transcript)	Seq length (peptide)
ENST00000315872	ENST00000272369	ROCK2	chr2	11484121	MEIS1	chr2	66775074	590	216
ENST00000315872	ENST00000398506	ROCK2	chr2	11484121	MEIS1	chr2	66775074	590	141
ENST00000315872	ENST00000407092	ROCK2	chr2	11484121	MEIS1	chr2	66775074	590	121
ENST00000315872	ENST00000444274	ROCK2	chr2	11484121	MEIS1	chr2	66775074	590	216
ENST00000315872	ENST00000488550	ROCK2	chr2	11484121	MEIS1	chr2	66775074	590	157
ENST00000315872	ENST00000495021	ROCK2	chr2	11484121	MEIS1	chr2	66775074	590	216
ENST00000315872	ENST00000560281	ROCK2	chr2	11484121	MEIS1	chr2	66775074	590	248

ORFfinder Result Based On The Fusion Transcript Sequences of the 5UTR-3CDS Fusion Genes for N-Truncated Protein Search.

Henst

Tenst

Hgene

Hchr

Hbp

Tgene

Tchr

Tbp

Seq length
(transcript)

Seq length
(peptide)

ORFfinder Result Based On The Fusion Transcript Sequences of the 5CDS-3UTR Fusion Genes for C-Truncated Protein Search.

Henst

Tenst

Hgene

Hchr

Hbp

Tgene

Tchr

Tbp

Seq length
(transcript)

Seq length
(peptide)

DeepORF Prediction of The Coding Potential Based on The Fusion Transcript Sequence of In-frame Fusion Genes. DeepORF is a Coding Potential Classifier Based on Convolutional Neural Network by Comparing the Real Ribo-seq Data. If the No-coding Score < 0.5 and Coding Score > 0.5, Then The In-frame Fusion Transcript is Predicted as Being Likely Translated.

Henst	Tenst	Hgene	Hchr	Hbp	Tgene	Tchr	Tbp	No-coding score	Coding score
ENST00000315872	ENST00000272369	ROCK2	chr2	11484121	MEIS1	chr2	66775074	3.66e-01	6.34e-01
ENST00000315872	ENST00000398506	ROCK2	chr2	11484121	MEIS1	chr2	66775074	6.16e-02	9.38e-01
ENST00000315872	ENST00000407092	ROCK2	chr2	11484121	MEIS1	chr2	66775074	6.16e-02	9.38e-01
ENST00000315872	ENST00000444274	ROCK2	chr2	11484121	MEIS1	chr2	66775074	1.15e-02	9.89e-01
ENST00000315872	ENST00000488550	ROCK2	chr2	11484121	MEIS1	chr2	66775074	4.38e-01	5.62e-01
ENST00000315872	ENST00000495021	ROCK2	chr2	11484121	MEIS1	chr2	66775074	2.42e-02	9.76e-01
ENST00000315872	ENST00000560281	ROCK2	chr2	11484121	MEIS1	chr2	66775074	1.92e-01	8.08e-01

DeepORF Prediction of The Coding Potential Based on The Fusion Transcript Sequence of 5UTR-3CDS Fusion Genes (Potential N-Truncated Proteins).

Henst

Tenst

Hgene

Hchr

Hbp

Tgene

Tchr

Tbp

No-coding score

Coding score

DeepORF Prediction of The Coding Potential Based on The Fusion Transcript Sequence of 5CDS-3UTR Fusion Genes (Potential C-Truncated Proteins).

Henst	Tenst	Hgene	Hchr	Hbp	Tgene	Tchr	Tbp	No-coding score	Coding score
ENST00000315872	ENST00000409517	ROCK2	chr2	11484121	MEIS1	chr2	66775074	0.00e+00	1.20e-02

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Fusion Protein Retained/Non-Retained Functional Features for ROCK2_MEIS1

Protein Level Annotation from FGviewer
* Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at download page. Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features (visualization across fusion protein length).

ROCK2_MEIS1_chr2-11484121_chr2-66775074.png

- In-frame and retained protein feature among the 13 regional features (texts).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

ROCK2

chr2:11484121

chr2:66775074

ENST00000315872

O75116

1_27

47.0

1389.0

Region

Disordered

Tgene

MEIS1

chr2:11484121

chr2:66775074

ENST00000272369

O00470

335_390

296.0

1109.3333333333333

Region

Required for transcriptional activation

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

ROCK2

chr2:11484121

chr2:66775074

ENST00000315872

O75116

1053_1131

47.0

1389.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

ROCK2

chr2:11484121

chr2:66775074

ENST00000315872

O75116

429_1024

47.0

1389.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

ROCK2

chr2:11484121

chr2:66775074

ENST00000315872

O75116

1362_1376

47.0

1389.0

Compositional bias

Polar residues

Hgene

ROCK2

chr2:11484121

chr2:66775074

ENST00000315872

O75116

1150_1349

47.0

1389.0

Domain

Hgene

ROCK2

chr2:11484121

chr2:66775074

ENST00000315872

O75116

357_425

47.0

1389.0

Domain

AGC-kinase C-terminal

Hgene

ROCK2

chr2:11484121

chr2:66775074

ENST00000315872

O75116

497_573

47.0

1389.0

Domain

REM-1

Hgene

ROCK2

chr2:11484121

chr2:66775074

ENST00000315872

O75116

92_354

47.0

1389.0

Domain

Protein kinase

Hgene

ROCK2

chr2:11484121

chr2:66775074

ENST00000315872

O75116

1345_1388

47.0

1389.0

Region

Disordered

Hgene

ROCK2

chr2:11484121

chr2:66775074

ENST00000315872

O75116

979_1047

47.0

1389.0

Region

RHOA binding

Hgene

ROCK2

chr2:11484121

chr2:66775074

ENST00000315872

O75116

1260_1315

47.0

1389.0

Zinc finger

Phorbol-ester/DAG-type

Tgene

MEIS1

chr2:11484121

chr2:66775074

ENST00000272369

O00470

190_202

296.0

1109.3333333333333

Compositional bias

Basic and acidic residues

Tgene

MEIS1

chr2:11484121

chr2:66775074

ENST00000272369

O00470

203_213

296.0

1109.3333333333333

Compositional bias

Polar residues

Tgene

MEIS1

chr2:11484121

chr2:66775074

ENST00000272369

O00470

272_334

296.0

1109.3333333333333

DNA binding

Homeobox%3B TALE-type

Tgene

MEIS1

chr2:11484121

chr2:66775074

ENST00000272369

O00470

108_192

296.0

1109.3333333333333

Domain

MEIS N-terminal

Tgene

MEIS1

chr2:11484121

chr2:66775074

ENST00000272369

O00470

190_279

296.0

1109.3333333333333

Region

Disordered

- Retained PPIs in in-frame fusion.

Partner

Hgene

Hbp

Tgene

Tbp

ENST

UniProt

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Hgene

Hbp

Tgene

Tbp

ENST

UniProt

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Hgene

ROCK2

chr2:11484121

MEIS1

chr2:66775074

ENST00000315872

O75116

373_420

47.0

1389.0

Region

NPM1

Hgene

ROCK2

chr2:11484121

MEIS1

chr2:66775074

ENST00000315872

O75116

363_784

47.0

1389.0

Region

PPP1R12A

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Fusion Transcript Sequence for ROCK2_MEIS1

In-frame Fusion Transcript Sequences.

>ROCK2_MEIS1_ENST00000315872_ENST00000272369_11484121_66775074 length=3536nt 
 Breakpoint=590nt
CAAGGCGGCCGGCGGCGACCATGGCAGCGGGCCGGCGGCGGCCGTAGTGGCCCAGGCCTGGGCTTCAGCCTCCCGGGGCCCCAGAGGGCGGGGCGGTCCGGGCCGCGGCGGTGGCGGCGCCACTTCCCTGCTCCCGCCCGAGGACTCCTG
CGGGCACTCGCTGAGGACCAGCGGACCGGCGGCGCGAATCTGACTGAGGGGCGGGGACGCCGTCTGTTCCCCGCCGCTCCCGGCAGGGCCGGGCCGGGCTGGGCCGGGCTGGGCCGGGCGGGCCCCTGGGAGCAGCCCCCAGGCGGGGGA
CCGCCTTGGAGACCCGAAGCCGGAGCTAGAGGCAGGCGGTGGGCCCGGGTGGAGTCCCGGCCGGAGCTGGTGGTTCGGGGGCGGTGCTAGGCCCCGAGGCTGCGGGACCTGAGCGCGAGGAGCCTGAGTGCGGGTCCAGCGGTGGCGGCA
TGAGCCGGCCCCCGCCGACGGGGAAAATGCCCGGCGCCCCCGAGACCGCGCCGGGGGACGGGGCAGGCGCGAGCCGCCAGAGGAAGCTGGAGGCGCTGATCCGAGACCCTCGCTCCCCCATCAACGTGGAGAGCTTGCTGCACCCTTACC
CTTCTGAAGAACAGAAAAAGCAGTTGGCACAAGACACGGGACTCACCATCCTTCAAGTGAACAATTGGTTTATTAATGCCCGGAGAAGAATAGTGCAGCCCATGATAGACCAGTCCAACCGAGCAGTAAGTCAAGGAACACCTTATAATC
CTGATGGACAGCCCATGGGAGGTTTCGTAATGGACGGTCAGCAACATATGGGAATTAGAGCACCAGGACCTATGAGTGGAATGGGCATGAATATGGGCATGGAGGGGCAGTGGCACTACATGTAACCTTCATCTAGTTAACCAATCGCAA
AGCAAGGGGGAAGGCTGCAAAGTATGCCAGGGGAGTATGTAGCCCGGGGTGGTCCAATGGGTGTGAGTATGGGACAGCCAAGTTATACCCAACCCCAGATGCCCCCCCATCCTGCTCAGCTGCGTCATGGGCCCCCCATGCATACGTACA
TTCCTGGACACCCTCACCACCCAACAGTGATGATGCATGGAGGACCGCCCCACCCTGGAATGCCAATGTCAGCATCAAGCCCCACAGTTCTTAATACAGGAGACCCAACAATGAGTGGACAAGTCATGGACATTCATGCTCAGTAGCTTA
AGGGAATATGCATTGTCTGCAATGGTGACTGATTTCAAATCATGTTTTTTCTGCAATGACTGTGGAGTTCCATTCTTGGCATCTACTCTGGACCAAGGAGCATCCCTAATTCTTCATAGGGACCTTTAAAAAGCAGGAAATACCAACTGA
AGTCAATTTGGGGGACATGCTAAATAACTATATAAGACATTAAGAGAACAAAGAGTGAAATATTGTAAATGCTATTATACTGTTATCCATATTACGTTGTTTCTTATAGATTTTTTAAAAAAAATGTGAAATTTTTCCACACTATGTGTG
TTGTTTCCATAGCTCTTCACTTCCTCCAGAAGCCTCCTTACATTAAAAAGCCTTACAGTTATCCTGCAAGGGACAGGAAGGTCTGATTTGCAGGATTTTTAGAGCATTAAAATAACTATCAGGCAGAAGAATCTTTCTTCTCGCCTAGGA
TTTCAGCCATGCGCGCGCTCTCTCTCTTTCTCTCTCTTTTCCTCTCTCTCCCTCTTTCTAGCCTGGGGCTTGAATTTGCATGTCTAATTCATTTACTCACCATATTTGAATTGGCCTGAACAGATGTAAATCGGGAAGGATGGGAAAAAC
TGCAGTCATCAACAATGATTAATCAGCTGTTGCAGGCAGTGTCTTAAGGAGACTGGTAGGAGGAGGCATGGAAACCAAAAGGCCGTGTGTTTAGAAGCCTAATTGTCACATCAAGCATCATTGTCCCCATGCAACAACCACCACCTTATA
CATCACTTCCTGTTTTAAGCAGCTCTAAAACATAGACTGAAGATTTATTTTTAATATGTTGACTTTATTTCTGAGCAAAGCATCGGTCATGTGTGTATTTTTTCATAGTCCCACCTTGGAGCATTTATGTAGACATTGTAAATAAATTTT
GTGCAAAAAGGACTGGAAAAATGAACTGTATTATTGCAATTTTTTTTTGTAAAAGTAGCAGTTTGGTATGAGTTGGCATGCATACAAGATTTACTAAGTGGGATAAGCTAATTATACTTTTTGTTGTGGATAAACAAATGCTTGTTGATA
GCCTTTTTCTATCAAGAAACCAAGGAGCTAATTATTAATAACAATCATTGCACACTGAGTCTTAGCGTTTCTGATGGAAACAGTTTGGATTGTATAATAACGCCAAGCCCAGTTGTAGTCGTTTGAGTGCAGTAATGAAATCTGAATCTA
AAATAAAAACAAGATTATTTTTGTCATGCTGACTCCACTGCTTGAAAAATTTGTTTACTGCCCCCCAGATTTTTAAAGATTAATACAGTAAATATAAAAATTAATTTTGGCTCCCTAAGCCATATATGTATTTGACAATTTTAACCGCAA
AGTAAGTTGTTTAATAATAACCACTGATTTCTTTAAGCTGACTTAATGAACTCCTAATATCAGCAAATTTGAGGCCTAAAGGCACTAAACTAACTCTAGACTCAGAATTACATCCAACAGAATTACTCATCTAATATCAGTGAAATTATT
CTTGCACATAAAGGCAAACCTAAGTACAAAGTTAAGTCTTTTACTAAAGGATGTTACCTAGGATGAGCAGTATATGTTTATTAGGAAATTAACTACATGAATTGAAGAGACCAGACTTCAAAATCTAATTTTTATAAATATGCTCTATGT
TCTCATTGGATAAAACTGGTTATTAACCAATTTTCCAGAACAGCTGTACAAGATTTCTGCATGGCAGCCGGCTAAATGGTAGAAAATAATATGTTTAAGCTGGAATAGCTTATAATTTTATTTAAATAAAATTGCTGCTATAAAAAGTGC
TTCCCAAAGCTAAGGAAAATATACAAATATTTTAATTAAGGCAAATTCGTTTTAAAAAATAAGCCTTTCAGTAGTGATTGCTTTGTAAACAAAGGATGGGTCGGAGGAGAGAGAGCCTTAAACTCAAGTCTGACATTCAGGCCCAAGTCA
CCCTATAAACCGGCCCTTAGCAATTCTATTTTCTATTCGAAAAGAGAAACCAGCTGTGGGTTGGCTTTACTAGGTGATGTGTGATTGACTGACTCACCTGCTGGAGTAGCAATGCATTCTCACCTTTTGCTGATGGGGCCTTGTTTCTAA
ACACGTGGATGCGCAGAGAGCAAGGCTCAGCCTACTGCAGCCATCTCTGGCAGCGCTTCTACCCCTCCCCAGCCCATAGATGGGATTGTTTAAATCTCCCTTGTTGACCTAGTGGCAATTCTTCCTCTACCTAAATAGTCGATGTGAGTG
AAATCATTCTCTTTTGATAGGTGGTTGCTAGCAGTTAACAACCATTTATTTACTTTAACAATTAATAATAAACTTTATAAACTGTC

>ROCK2_MEIS1_ENST00000315872_ENST00000398506_11484121_66775074 length=2029nt 
 Breakpoint=590nt
CAAGGCGGCCGGCGGCGACCATGGCAGCGGGCCGGCGGCGGCCGTAGTGGCCCAGGCCTGGGCTTCAGCCTCCCGGGGCCCCAGAGGGCGGGGCGGTCCGGGCCGCGGCGGTGGCGGCGCCACTTCCCTGCTCCCGCCCGAGGACTCCTG
CGGGCACTCGCTGAGGACCAGCGGACCGGCGGCGCGAATCTGACTGAGGGGCGGGGACGCCGTCTGTTCCCCGCCGCTCCCGGCAGGGCCGGGCCGGGCTGGGCCGGGCTGGGCCGGGCGGGCCCCTGGGAGCAGCCCCCAGGCGGGGGA
CCGCCTTGGAGACCCGAAGCCGGAGCTAGAGGCAGGCGGTGGGCCCGGGTGGAGTCCCGGCCGGAGCTGGTGGTTCGGGGGCGGTGCTAGGCCCCGAGGCTGCGGGACCTGAGCGCGAGGAGCCTGAGTGCGGGTCCAGCGGTGGCGGCA
TGAGCCGGCCCCCGCCGACGGGGAAAATGCCCGGCGCCCCCGAGACCGCGCCGGGGGACGGGGCAGGCGCGAGCCGCCAGAGGAAGCTGGAGGCGCTGATCCGAGACCCTCGCTCCCCCATCAACGTGGAGAGCTTGCTGCACCCTTACC
CTTCTGAAGAACAGAAAAAGCAGTTGGCACAAGACACGGGACTCACCATCCTTCAAGTGAACAATTGGTTTATTAATGCCCGGAGAAGAATAGTGCAGCCCATGATAGACCAGTCCAACCGAGCAGTAAGTCAAGGAACACCTTATAATC
CTGATGGACAGCCCATGGGAGGTTTCGTAATGGACGGTCAGCAACATATGGGAATTAGAGCACCAGGGCTGCAAAGTATGCCAGGGGAGTATGTAGCCCGGGGTGGTCCAATGGGTGTGAGTATGGGACAGCCAAGTTATACCCAACCCC
AGATGCCCCCCCATCCTGCTCAGCTGCGTCATGGGCCCCCCATGCATACGTACATTCCTGGACACCCTCACCACCCAACAGTGATGATGCATGGAGGACCGCCCCACCCTGGAATGCCAATGTCAGCATCAAGCCCCACAGTTCTTAATA
CAGGAGACCCAACAATGAGTGGACAAGTCATGGACATTCATGCTCAGTAGCTTAAGGGAATATGCATTGTCTGCAATGGTGACTGATTTCAAATCATGTTTTTTCTGCAATGACTGTGGAGTTCCATTCTTGGCATCTACTCTGGACCAA
GGAGCATCCCTAATTCTTCATAGGGACCTTTAAAAAGCAGGAAATACCAACTGAAGTCAATTTGGGGGACATGCTAAATAACTATATAAGACATTAAGAGAACAAAGAGTGAAATATTGTAAATGCTATTATACTGTTATCCATATTACG
TTGTTTCTTATAGATTTTTTAAAAAAAATGTGAAATTTTTCCACACTATGTGTGTTGTTTCCATAGCTCTTCACTTCCTCCAGAAGCCTCCTTACATTAAAAAGCCTTACAGTTATCCTGCAAGGGACAGGAAGGTCTGATTTGCAGGAT
TTTTAGAGCATTAAAATAACTATCAGGCAGAAGAATCTTTCTTCTCGCCTAGGATTTCAGCCATGCGCGCGCTCTCTCTCTTTCTCTCTCTTTTCCTCTCTCTCCCTCTTTCTAGCCTGGGGCTTGAATTTGCATGTCTAATTCATTTAC
TCACCATATTTGAATTGGCCTGAACAGATGTAAATCGGGAAGGATGGGAAAAACTGCAGTCATCAACAATGATTAATCAGCTGTTGCAGGCAGTGTCTTAAGGAGACTGGTAGGAGGAGGCATGGAAACCAAAAGGCCGTGTGTTTAGAA
GCCTAATTGTCACATCAAGCATCATTGTCCCCATGCAACAACCACCACCTTATACATCACTTCCTGTTTTAAGCAGCTCTAAAACATAGACTGAAGATTTATTTTTAATATGTTGACTTTATTTCTGAGCAAAGCATCGGTCATGTGTGT
ATTTTTTCATAGTCCCACCTTGGAGCATTTATGTAGACATTGTAAATAAATTTTGTGCAAAAAGGACTGGAAAAATGAA

>ROCK2_MEIS1_ENST00000315872_ENST00000407092_11484121_66775074 length=2329nt 
 Breakpoint=590nt
CAAGGCGGCCGGCGGCGACCATGGCAGCGGGCCGGCGGCGGCCGTAGTGGCCCAGGCCTGGGCTTCAGCCTCCCGGGGCCCCAGAGGGCGGGGCGGTCCGGGCCGCGGCGGTGGCGGCGCCACTTCCCTGCTCCCGCCCGAGGACTCCTG
CGGGCACTCGCTGAGGACCAGCGGACCGGCGGCGCGAATCTGACTGAGGGGCGGGGACGCCGTCTGTTCCCCGCCGCTCCCGGCAGGGCCGGGCCGGGCTGGGCCGGGCTGGGCCGGGCGGGCCCCTGGGAGCAGCCCCCAGGCGGGGGA
CCGCCTTGGAGACCCGAAGCCGGAGCTAGAGGCAGGCGGTGGGCCCGGGTGGAGTCCCGGCCGGAGCTGGTGGTTCGGGGGCGGTGCTAGGCCCCGAGGCTGCGGGACCTGAGCGCGAGGAGCCTGAGTGCGGGTCCAGCGGTGGCGGCA
TGAGCCGGCCCCCGCCGACGGGGAAAATGCCCGGCGCCCCCGAGACCGCGCCGGGGGACGGGGCAGGCGCGAGCCGCCAGAGGAAGCTGGAGGCGCTGATCCGAGACCCTCGCTCCCCCATCAACGTGGAGAGCTTGCTGCACCCTTACC
CTTCTGAAGAACAGAAAAAGCAGTTGGCACAAGACACGGGACTCACCATCCTTCAAGTGAACAATTGGTTTATTAATGCCCGGAGAAGAATAGTGCAGCCCATGATAGACCAGTCCAACCGAGCAGTAAGTCAAGGAACACCTTATAATC
CTGATGGACAGCCCATGGGAGGTTTCGTAATGGACGGTCAGCAACATATGGGAATTAGAGCACCAGGGCTGCAAAGTATGCCAGGGGAGTATGTAGCCCGGGGTGGTCCAATGGGTGTGAGTATGGGACAGCCAAGTTATACCCAACCCC
AGATGCCCCCCCATCCTGCTCAGCTGCGTCATGGGCCCCCCATGCATACGTACATTCCTGGACACCCTCACCACCCAACAGTGATGATGCATGGAGGACCGCCCCACCCTGGAATGCCAATGTCAGCATCAAGCCCCACAGTTCTTAATA
CAGGAGACCCAACAATGAGTGGACAAGTCATGGACATTCATGCTCAGTAGCTTAAGGGAATATGCATTGTCTGCAATGGTGACTGATTTCAAATCATGTTTTTTCTGCAATGACTGTGGAGTTCCATTCTTGGCATCTACTCTGGACCAA
GGAGCATCCCTAATTCTTCATAGGGACCTTTAAAAAGCAGGAAATACCAACTGAAGTCAATTTGGGGGACATGCTAAATAACTATATAAGACATTAAGAGAACAAAGAGTGAAATATTGTAAATGCTATTATACTGTTATCCATATTACG
TTGTTTCTTATAGATTTTTTAAAAAAAATGTGAAATTTTTCCACACTATGTGTGTTGTTTCCATAGCTCTTCACTTCCTCCAGAAGCCTCCTTACATTAAAAAGCCTTACAGTTATCCTGCAAGGGACAGGAAGGTCTGATTTGCAGGAT
TTTTAGAGCATTAAAATAACTATCAGGCAGAAGAATCTTTCTTCTCGCCTAGGATTTCAGCCATGCGCGCGCTCTCTCTCTTTCTCTCTCTTTTCCTCTCTCTCCCTCTTTCTAGCCTGGGGCTTGAATTTGCATGTCTAATTCATTTAC
TCACCATATTTGAATTGGCCTGAACAGATGTAAATCGGGAAGGATGGGAAAAACTGCAGTCATCAACAATGATTAATCAGCTGTTGCAGGCAGTGTCTTAAGGAGACTGGTAGGAGGAGGCATGGAAACCAAAAGGCCGTGTGTTTAGAA
GCCTAATTGTCACATCAAGCATCATTGTCCCCATGCAACAACCACCACCTTATACATCACTTCCTGTTTTAAGCAGCTCTAAAACATAGACTGAAGATTTATTTTTAATATGTTGACTTTATTTCTGAGCAAAGCATCGGTCATGTGTGT
ATTTTTTCATAGTCCCACCTTGGAGCATTTATGTAGACATTGTAAATAAATTTTGTGCAAAAAGGACTGGAAAAATGAACTGTATTATTGCAATTTTTTTTTGTAAAAGTAGCAGTTTGGTATGAGTTGGCATGCATACAAGATTTACTA
AGTGGGATAAGCTAATTATACTTTTTGTTGTGGATAAACAAATGCTTGTTGATAGCCTTTTTCTATCAAGAAACCAAGGAGCTAATTATTAATAACAATCATTGCACACTGAGTCTTAGCGTTTCTGATGGAAACAGTTTGGATTGTATA
ATAACGCCAAGCCCAGTTGTAGTCGTTTGAGTGCAGTAATGAAATCTGAATCTAAAATAAAAACAAGATTATTTTTGTC

>ROCK2_MEIS1_ENST00000315872_ENST00000444274_11484121_66775074 length=1429nt 
 Breakpoint=590nt
CAAGGCGGCCGGCGGCGACCATGGCAGCGGGCCGGCGGCGGCCGTAGTGGCCCAGGCCTGGGCTTCAGCCTCCCGGGGCCCCAGAGGGCGGGGCGGTCCGGGCCGCGGCGGTGGCGGCGCCACTTCCCTGCTCCCGCCCGAGGACTCCTG
CGGGCACTCGCTGAGGACCAGCGGACCGGCGGCGCGAATCTGACTGAGGGGCGGGGACGCCGTCTGTTCCCCGCCGCTCCCGGCAGGGCCGGGCCGGGCTGGGCCGGGCTGGGCCGGGCGGGCCCCTGGGAGCAGCCCCCAGGCGGGGGA
CCGCCTTGGAGACCCGAAGCCGGAGCTAGAGGCAGGCGGTGGGCCCGGGTGGAGTCCCGGCCGGAGCTGGTGGTTCGGGGGCGGTGCTAGGCCCCGAGGCTGCGGGACCTGAGCGCGAGGAGCCTGAGTGCGGGTCCAGCGGTGGCGGCA
TGAGCCGGCCCCCGCCGACGGGGAAAATGCCCGGCGCCCCCGAGACCGCGCCGGGGGACGGGGCAGGCGCGAGCCGCCAGAGGAAGCTGGAGGCGCTGATCCGAGACCCTCGCTCCCCCATCAACGTGGAGAGCTTGCTGCACCCTTACC
CTTCTGAAGAACAGAAAAAGCAGTTGGCACAAGACACGGGACTCACCATCCTTCAAGTGAACAATTGGTTTATTAATGCCCGGAGAAGAATAGTGCAGCCCATGATAGACCAGTCCAACCGAGCAGTAAGTCAAGGAACACCTTATAATC
CTGATGGACAGCCCATGGGAGGTTTCGTAATGGACGGTCAGCAACATATGGGAATTAGAGCACCAGGGCTGCAAAGTATGCCAGGGGAGTATGTAGCCCGGGGTGGTCCAATGGGTGTGAGTATGGGACAGCCAAGTTATACCCAACCCC
AGATGCCCCCCCATCCTGCTCAGCTGCGTCATGGGCCCCCCATGCATACGTACATTCCTGGACACCCTCACCACCCAACAGTGATGATGCATGGAGGACCGCCCCACCCTGGAATGCCAATGTCAGCATCAAGCCCCACAGTTCTTAATA
CAGGAGACCCAACAATGAGTGGACAAGTCATGGACATTCATGCTCAGTAGCTTAAGGGAATATGCATTGTCTGCAATGGTGACTGATTTCAAATCATGTTTTTTCTGCAATGACTGTGGAGTTCCATTCTTGGCATCTACTCTGGACCAA
GGAGCATCCCTAATTCTTCATAGGGACCTTTAAAAAGCAGGAAATACCAACTGAAGTCAATTTGGGGGACATGCTAAATAACTATATAAGACATTAAGAGAACAAAGAGTGAAATATTGTAAATGCTATTATACTGTTATCCATATTACG
TTGTTTCTTATAGATTTTTTAAAAAAAATGTGAAATTTTTCCACACTATGTGTGTTGTTTCCATAGCTCTTCACTTCCT

>ROCK2_MEIS1_ENST00000315872_ENST00000488550_11484121_66775074 length=4514nt 
 Breakpoint=590nt
CAAGGCGGCCGGCGGCGACCATGGCAGCGGGCCGGCGGCGGCCGTAGTGGCCCAGGCCTGGGCTTCAGCCTCCCGGGGCCCCAGAGGGCGGGGCGGTCCGGGCCGCGGCGGTGGCGGCGCCACTTCCCTGCTCCCGCCCGAGGACTCCTG
CGGGCACTCGCTGAGGACCAGCGGACCGGCGGCGCGAATCTGACTGAGGGGCGGGGACGCCGTCTGTTCCCCGCCGCTCCCGGCAGGGCCGGGCCGGGCTGGGCCGGGCTGGGCCGGGCGGGCCCCTGGGAGCAGCCCCCAGGCGGGGGA
CCGCCTTGGAGACCCGAAGCCGGAGCTAGAGGCAGGCGGTGGGCCCGGGTGGAGTCCCGGCCGGAGCTGGTGGTTCGGGGGCGGTGCTAGGCCCCGAGGCTGCGGGACCTGAGCGCGAGGAGCCTGAGTGCGGGTCCAGCGGTGGCGGCA
TGAGCCGGCCCCCGCCGACGGGGAAAATGCCCGGCGCCCCCGAGACCGCGCCGGGGGACGGGGCAGGCGCGAGCCGCCAGAGGAAGCTGGAGGCGCTGATCCGAGACCCTCGCTCCCCCATCAACGTGGAGAGCTTGCTGCACCCTTACC
CTTCTGAAGAACAGAAAAAGCAGTTGGCACAAGACACGGGACTCACCATCCTTCAAGTGAACAATTGGTTTATTAATGCCCGGAGAAGAATAGTGCAGCCCATGATAGACCAGTCCAACCGAGCAGTAAGTCAAGGAACACCTTATAATC
CTGATGGACAGCCCATGGGAGGTTTCGTAATGGACGGTCAGCAACATATGGGAATTAGAGCACCAGGTAAGACTTTGTTTTTGTGGTAGTTCCTCATTTTTGACTCCAAGAGTGTCATCCCCTCATCAACACAGGTAAATCCGCCTCATC
CTTTTCTGTTATCTCAAGCTGGCTGCCTTGCCTTGTCTGCTATCTGTGCATCTAAGATATTGCAGAGGGGAAGCCAGGATCTTTATGCACTGAAGATCTCACTATTTCTCAACCCTCTAGATCCTGTTTTTTTTTTAAGGGTCTTTTGGC
ACTATCTGTTGACTTTGCTCATTTTCTGGCCTCTTCTTGGATTTTTATCTCCCTTCTAGGACCTATGAGTGGAATGGGCATGAATATGGGCATGGAGGGGCAGTGGCACTACATGTAACCTTCATCTAGTTAACCAATCGCAAAGCAAGG
GGGAAGTAAGTACAAATGGGGTCTTTGTTTTCACTTTGTCCTAGGAATATTTTTCCTCTTGCATTTTCTTATGTTCTCCTTGCCCATAGCTTCATGCTTGTTCATTCCTTTCCATTAAACTCCTGGTTTCTTGCTTCCATCATTTTCTTT
TTGGTTGTGATCAAGCTTTTAAGCTTATAAATACTGTGTATGATGTACATTTATCCTGTGTGTTGCTATTGTACAGTACTGACCACATGACAAAACAAGAAGCAGTCAGGAGGTGGGGGAGTGGGTTGTCATAGCAACAGACTGATTTGC
AAAATGTAAGCAGTCTGCAGCAGTGCAAGGAGAGGGAAGAGCATGTCCCCAAAGTGTCATAAATCTGTCTAACCGCAGTTGATGCATGAGTTACATTTCTACACTAACCTGCAAGACACCGAAAAGCTAAACAGAGACTTCTTTTAGGTA
AAATAAACACAAGCTTTACTTAGGGTAAGTAAAGGCATATTTTGAGCTCCAGTCAACTAAACTTTGATTTTTTTTCTTAGTTTATTCCTTTGTCTGTCCATCATAATGGGATTACGTGTGGCAATGGGAAAAGGGAGAATACAAAATAGA
GGTGTGCACAGCAGGCTGCGGGGCTTAGCCCAGGCTAATTGACTATATCCAAATTAAGTATGCCATCACTTGCAGTGTGACAAATGGATTTGACTTATTCAGTATACAAAAATAGAGATCATTAATGCAATCATCAGTGGCAGGCCTAGT
GAAGTGGGCCTAGGAAAACTGTCCCAGATTCTCACTCTTGCATTTTCTCTCCTATAAAGACACTCCAGCAATTCGAGTTCAAACAAGTAAAACTGTTTTGAACACCAAGGCTCTTGTTCACTTCCTAAATTACCCCTAATAGCACTGTTC
TTGCTTTGTTTTTGAAATTAAAAGCAGTTATTTCAGAGTCTTGCTTGTGTCTCTGATTATATTTATGCACTATTTAAAATCACTGCTGAGGCCAGGGGTAATTCGTACTGGTCATCTTCTCTGGGTGTGAGTCAAATATAAGTTTAACAA
TTAGCTCTGAAAACATTCCATTGAGCTGGGGAATGCAACAGTCTTATTACCTCATCATGGAATTCTCTAGCTTAGTTAATTTAAATATTGTTTCTTAGTTTCTGGGTCAATTAAATTTAAATGATGTATTTTATGCTTCGTGACCAATTA
AATTACTAGGTTATTACAAAAAAAATTATCATCTTTTTTGATTAAAGAGCTGTGGGTACAGTATATTTTATAAGCAATTTTCATTAGTTCAAAAATGTTCCTTTAGGCTAGATTAAGCAGCCATTCATTGTTAGAGCCTGGAGACCTTAT
TCGAAGGTGTTCATCGTATTCACAGTGCACTATTACTTAGAACTAAAGCCAATTGAACCTACTTAGCAATAGCGTTATGCCTTTCACCCTTGATGATTATGGAGCTTATAGCTCTCAGAAACAATACACCTGTCAGTTTCCATCAACTAT
AGCAATCCATGCAGAAGACAAGAGGCCCCCTCAAAGCAGGAGGGGTATTGTTTTAGGTCCAATTTTTCTTATTGTTCTCAAAATCATTATAAGGTGGACAGTGTTTTGTGAAGATTTTCTTTTCCCCAGCTCTAAGAAACCATGTGGAAA
GAATTCATTGATAACTGTTTTGATTTTTTTCTTTTTTTAAGTACAGGTTTTGCTAAGTAATCACCCTTAGTGAGCCTGTGTAGTTCAGCTGCCTGTGAGATGTTTGGTGACCAGCTCAGTGTATTCTTGTATTCTTGATAGAGAATATTT
CAGGAGACAAAAGTGCTTCTTCAGACCAGACCTCAAATAACAATTTTATTCTTTTTAATAAATAAGACCTCAGTAGGCGGACCTGATAACAGTGACAATGAAAGGAAAATAGTGGCAAAATGTGAGTTTCCAGCATGATGTTTCTCATTT
TATTTTCTTCTGTATGAATCAAAAGAATGCTTTACAAAACCATGTTCCCTTAATCACAGGGTTCTCTGGCTTTTATAGGATTGTCATAGCCAGGACCACACTATTGCTTTTTCATAACATTTTCTTTTTGTTTCTTTCTTTTGAATTTCT
TACAGGGCTGCAAAGTATGCCAGGGGAGTATGTAGCCCGGGGTGGTCCAATGGGTGTGAGTATGGGACAGCCAAGTTATACCCAACCCCAGATGCCCCCCCATCCTGCTCAGCTGCGTCATGGGCCCCCCATGCATACGTACATTCCTGG
ACACCCTCACCACCCAACAGTGATGATGCATGGAGGACCGCCCCACCCTGGAATGCCAATGTCAGCATCAAGCCCCACAGTTCTTAATACAGGAGACCCAACAATGAGTGGACAAGTCATGGACATTCATGCTCAGTAGCTTAAGGGAAT
ATGCATTGTCTGCAATGGTGACTGATTTCAAATCATGTTTTTTCTGCAATGACTGTGGAGTTCCATTCTTGGCATCTACTCTGGACCAAGGAGCATCCCTAATTCTTCATAGGGACCTTTAAAAAGCAGGAAATACCAACTGAAGTCAAT
TTGGGGGACATGCTAAATAACTATATAAGACATTAAGAGAACAAAGAGTGAAATATTGTAAATGCTATTATACTGTTATCCATATTACGTTGTTTCTTATAGATTTTTTAAAAAAAATGTGAAATTTTTCCACACTATGTGTGTTGTTTC
CATAGCTCTTCACTTCCTCCAGAAGCCTCCTTACATTAAAAAGCCTTACAGTTATCCTGCAAGGGACAGGAAGGTCTGATTTGCAGGATTTTTAGAGCATTAAAATAACTATCAGGCAGAAGAATCTTTCTTCTCGCCTAGGATTTCAGC
CATGCGCGCGCTCTCTCTCTTTCTCTCTCTTTTCCTCTCTCTCCCTCTTTCTAGCCTGGGGCTTGAATTTGCATGTCTAATTCATTTACTCACCATATTTGAATTGGCCTGAACAGATGTAAATCGGGAAGGATGGGAAAAACTGCAGTC
ATCAACAATGATTAATCAGCTGTTGCAGGCAGTGTCTTAAGGAGACTGGTAGGAGGAGGCATGGAAACCAAAAGGCCGTGTGTTTAGAAGCCTAATTGTCACATCAAGCATCATTGTCCCCATGCAACAACCACCACCTTATACATCACT
TCCTGTTTTAAGCAGCTCTAAAACATAGACTGAAGATTTATTTTTAATATGTTGACTTTATTTCTGAGCAAAGCATCGGTCATGTGTGTATTTTTTCATAGTCCCACCTTGGAGCATTTATGTAGACATTGTAAATAAATTTTGTGCAAA
AAGGACTGGAAAAA

>ROCK2_MEIS1_ENST00000315872_ENST00000495021_11484121_66775074 length=1503nt 
 Breakpoint=590nt
CAAGGCGGCCGGCGGCGACCATGGCAGCGGGCCGGCGGCGGCCGTAGTGGCCCAGGCCTGGGCTTCAGCCTCCCGGGGCCCCAGAGGGCGGGGCGGTCCGGGCCGCGGCGGTGGCGGCGCCACTTCCCTGCTCCCGCCCGAGGACTCCTG
CGGGCACTCGCTGAGGACCAGCGGACCGGCGGCGCGAATCTGACTGAGGGGCGGGGACGCCGTCTGTTCCCCGCCGCTCCCGGCAGGGCCGGGCCGGGCTGGGCCGGGCTGGGCCGGGCGGGCCCCTGGGAGCAGCCCCCAGGCGGGGGA
CCGCCTTGGAGACCCGAAGCCGGAGCTAGAGGCAGGCGGTGGGCCCGGGTGGAGTCCCGGCCGGAGCTGGTGGTTCGGGGGCGGTGCTAGGCCCCGAGGCTGCGGGACCTGAGCGCGAGGAGCCTGAGTGCGGGTCCAGCGGTGGCGGCA
TGAGCCGGCCCCCGCCGACGGGGAAAATGCCCGGCGCCCCCGAGACCGCGCCGGGGGACGGGGCAGGCGCGAGCCGCCAGAGGAAGCTGGAGGCGCTGATCCGAGACCCTCGCTCCCCCATCAACGTGGAGAGCTTGCTGCACCCTTACC
CTTCTGAAGAACAGAAAAAGCAGTTGGCACAAGACACGGGACTCACCATCCTTCAAGTGAACAATTGGTTTATTAATGCCCGGAGAAGAATAGTGCAGCCCATGATAGACCAGTCCAACCGAGCAGTAAGTCAAGGAACACCTTATAATC
CTGATGGACAGCCCATGGGAGGTTTCGTAATGGACGGTCAGCAACATATGGGAATTAGAGCACCAGGACCTATGAGTGGAATGGGCATGAATATGGGCATGGAGGGGCAGTGGCACTACATGTAACCTTCATCTAGTTAACCAATCGCAA
AGCAAGGGGGAAGGCTGCAAAGTATGCCAGGGGAGTATGTAGCCCGGGGTGGTCCAATGGGTGTGAGTATGGGACAGCCAAGTTATACCCAACCCCAGATGCCCCCCCATCCTGCTCAGCTGCGTCATGGGCCCCCCATGCATACGTACA
TTCCTGGACACCCTCACCACCCAACAGTGATGATGCATGGAGGACCGCCCCACCCTGGAATGCCAATGTCAGCATCAAGCCCCACAGTTCTTAATACAGGAGACCCAACAATGAGTGGACAAGTCATGGACATTCATGCTCAGTAGCTTA
AGGGAATATGCATTGTCTGCAATGGTGACTGATTTCAAATCATGTTTTTTCTGCAATGACTGTGGAGTTCCATTCTTGGCATCTACTCTGGACCAAGGAGCATCCCTAATTCTTCATAGGGACCTTTAAAAAGCAGGAAATACCAACTGA
AGTCAATTTGGGGGACATGCTAAATAACTATATAAGACATTAAGAGAACAAAGAGTGAAATATTGTAAATGCTATTATACTGTTATCCATATTACGTTGTTTCTTATAGATTTTTTAAAAAAAATGTGAAATTTTTCCACACTATGTGTG
TTG

>ROCK2_MEIS1_ENST00000315872_ENST00000560281_11484121_66775074 length=1751nt 
 Breakpoint=590nt
CAAGGCGGCCGGCGGCGACCATGGCAGCGGGCCGGCGGCGGCCGTAGTGGCCCAGGCCTGGGCTTCAGCCTCCCGGGGCCCCAGAGGGCGGGGCGGTCCGGGCCGCGGCGGTGGCGGCGCCACTTCCCTGCTCCCGCCCGAGGACTCCTG
CGGGCACTCGCTGAGGACCAGCGGACCGGCGGCGCGAATCTGACTGAGGGGCGGGGACGCCGTCTGTTCCCCGCCGCTCCCGGCAGGGCCGGGCCGGGCTGGGCCGGGCTGGGCCGGGCGGGCCCCTGGGAGCAGCCCCCAGGCGGGGGA
CCGCCTTGGAGACCCGAAGCCGGAGCTAGAGGCAGGCGGTGGGCCCGGGTGGAGTCCCGGCCGGAGCTGGTGGTTCGGGGGCGGTGCTAGGCCCCGAGGCTGCGGGACCTGAGCGCGAGGAGCCTGAGTGCGGGTCCAGCGGTGGCGGCA
TGAGCCGGCCCCCGCCGACGGGGAAAATGCCCGGCGCCCCCGAGACCGCGCCGGGGGACGGGGCAGGCGCGAGCCGCCAGAGGAAGCTGGAGGCGCTGATCCGAGACCCTCGCTCCCCCATCAACGTGGAGAGCTTGCTGCACCCTTACC
CTTCTGAAGAACAGAAAAAGCAGTTGGCACAAGACACGGGACTCACCATCCTTCAAGTGAACAATTGGTTTATTAATGCCCGGAGAAGAATAGTGCAGCCCATGATAGACCAGTCCAACCGAGCAGGCAAGTCCCCCATAGTGACTGTAT
TCAAGTCACGCAAGCGAAAACCATCCTCAAGCCATTCACCGGGAGGTCCGCTACCTGGTAAATAAACTGGGAGTGAGTATAGGAACGCCTGGCAATTAAAATTAAACCAGTTTCGTTTCATAACAACACTAATCAATTTAACATCATTAT
AAAACGTTTGGAGAAGGTGGAAAAAAAAAGCCAACAGAGAAAAGTAACTCTTAAATAATATGCTCAGTTACAATATTCTTTGTACACATTCAATATATTAATGTTATTTTTTTTCTGAGTTTGCCTTCCCAGCTCTTTCTGCTACTATGA
CCACTCCCTGGTGCATGGCTTGGTGTGGAATTGCTGTAAACTTTATTACCTGTCAAAAGGGCAAAGGGGTCAGGATTGCTTGTGGGACTCAGTAAAGTTCAAAGACATTCAATGAGGTAGAGCTTTTGTGTGCTTTAATAACCCAAGGCA
GCTTACTTCTGAAGCAGCTTTTCATGTACAGTTAAAACACGGGATTCAGGTAGTGGTATAAATACATGGTTCTTATTTCTCAGACCTTCTCTTGTTAATATCCATCTTCTGGTGTTCGACTTTTTTTTTTTTTAATAACAGTCTTTTTGT
TTTGTTTTTAAATTATGAGCTTAAAATGGCGATACTTCTATGGGATCCTGGCTTGTGGATCTAAAAATCCAAGAAACATCTCTCTAGGATTTGTTTTTGCATTATAATATGCCAGTAAGATAACAAGAGTATTTGCTAGGGGTGATGTGA
GTCTTTACTTTCTTTATGAAATACTCTCTCATCTCTTAGGGAGCACTATGGAAAACTATGTTAGCATCGCATTGAGGCAACACACATTTACTCCTGTAACTTTTTTTCTTCCAACACCCATTATGTGGTCACCAGACAAAACCCAAGCAG
AAAGTTTCCACACCTTAACTGTTCCCTCTTTGAGCTAGATGTTTTAAAAACTCAGTCACAGAGGTGTGTAGATCTAGTCTGAGAGAAATTTCACTTTGAAT

N-Truncated Transcript (5UTR-3CDS) Sequences

C-Truncated Transcript (5CDS-3UTR) Sequences

>ROCK2_MEIS1_ENST00000315872_ENST00000409517_11484121_66775074 length=590nt 
 Breakpoint=590nt
CAAGGCGGCCGGCGGCGACCATGGCAGCGGGCCGGCGGCGGCCGTAGTGGCCCAGGCCTGGGCTTCAGCCTCCCGGGGCCCCAGAGGGCGGGGCGGTCCGGGCCGCGGCGGTGGCGGCGCCACTTCCCTGCTCCCGCCCGAGGACTCCTG
CGGGCACTCGCTGAGGACCAGCGGACCGGCGGCGCGAATCTGACTGAGGGGCGGGGACGCCGTCTGTTCCCCGCCGCTCCCGGCAGGGCCGGGCCGGGCTGGGCCGGGCTGGGCCGGGCGGGCCCCTGGGAGCAGCCCCCAGGCGGGGGA
CCGCCTTGGAGACCCGAAGCCGGAGCTAGAGGCAGGCGGTGGGCCCGGGTGGAGTCCCGGCCGGAGCTGGTGGTTCGGGGGCGGTGCTAGGCCCCGAGGCTGCGGGACCTGAGCGCGAGGAGCCTGAGTGCGGGTCCAGCGGTGGCGGCA
TGAGCCGGCCCCCGCCGACGGGGAAAATGCCCGGCGCCCCCGAGACCGCGCCGGGGGACGGGGCAGGCGCGAGCCGCCAGAGGAAGCTGGAGGCGCTGATCCGAGACCCTCGCTCCCCCATCAACGTGGAGAGCTTGCTG

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Fusion Protein Sequence for ROCK2_MEIS1

In-frame Fusion Protein Sequences.

>ROCK2_MEIS1_ENST00000315872_ENST00000272369_11484121_66775074 length=216nt
MSRPPPTGKMPGAPETAPGDGAGASRQRKLEALIRDPRSPINVESLLHPYPSEEQKKQLAQDTGLTILQVNNWFINARRRIVQPMIDQSNRAVSQGTPYNPDGQPMGGFVMDGQQHMGIRAPGLQSMPGEYVARGGPMGVSMGQPSYTQP
QMPPHPAQLRHGPPMHTYIPGHPHHPTVMMHGGPPHPGMPMSASSPTVLNTGDPTMSGQVMDIHAQ

>ROCK2_MEIS1_ENST00000315872_ENST00000398506_11484121_66775074 length=141nt
MNQKNALQNHVPLITGFSGFYRIVIARTTLLLFHNIFFLFLSFEFLTGLQSMPGEYVARGGPMGVSMGQPSYTQPQMPPHPAQLRHGPPMHTYIPGHPHHPTVMMHGGPPHPGMPMSASSPTVLNTGDPTMSGQVMDIHAQ

>ROCK2_MEIS1_ENST00000315872_ENST00000407092_11484121_66775074 length=121nt
MSRPPPTGKMPGAPETAPGDGAGASRQRKLEALIRDPRSPINVESLLHPYPSEEQKKQLAQDTGLTILQVNNWFINARRRIVQPMIDQSNRAGKSPIVTVFKSRKRKPSSSHSPGGPLPGK

>ROCK2_MEIS1_ENST00000315872_ENST00000444274_11484121_66775074 length=216nt
MSRPPPTGKMPGAPETAPGDGAGASRQRKLEALIRDPRSPINVESLLHPYPSEEQKKQLAQDTGLTILQVNNWFINARRRIVQPMIDQSNRAVSQGTPYNPDGQPMGGFVMDGQQHMGIRAPGLQSMPGEYVARGGPMGVSMGQPSYTQP
QMPPHPAQLRHGPPMHTYIPGHPHHPTVMMHGGPPHPGMPMSASSPTVLNTGDPTMSGQVMDIHAQ

>ROCK2_MEIS1_ENST00000315872_ENST00000488550_11484121_66775074 length=157nt
MPLHAHIHAHSTHRSWCSNSHMLLTVHYETSHGLSIRIIRCSLTYCSVGLVYHGLHYSSPGINKPIVHLKDGESRVLCQLLFLFFRRVRVQQALHVDGGARVSDQRLQLPLAARACPVPRRGLGGAGHFPRRRGPAHAATAGPALRLLAL
RSRSLGA

>ROCK2_MEIS1_ENST00000315872_ENST00000495021_11484121_66775074 length=216nt
MSRPPPTGKMPGAPETAPGDGAGASRQRKLEALIRDPRSPINVESLLHPYPSEEQKKQLAQDTGLTILQVNNWFINARRRIVQPMIDQSNRAVSQGTPYNPDGQPMGGFVMDGQQHMGIRAPGLQSMPGEYVARGGPMGVSMGQPSYTQP
QMPPHPAQLRHGPPMHTYIPGHPHHPTVMMHGGPPHPGMPMSASSPTVLNTGDPTMSGQVMDIHAQ

>ROCK2_MEIS1_ENST00000315872_ENST00000560281_11484121_66775074 length=248nt
MSRPPPTGKMPGAPETAPGDGAGASRQRKLEALIRDPRSPINVESLLTRPPTDLSFNFDANKQQRQLIAELENKNREILQEIQRLRLEHEQASQPTPEKAQQNPTLLAELRLLRQRKDELEQRMSALQESRRELMVQLEELMKLLKAQAT
GSPHTSPTHGGGRPMPMPVRSTSAGSTPTHCPQDSLSGVGGDVQEAFAQGTRRNLRNDLLVAADSITNTMSSLVKELHSAEEGAEEEEEKMQNGKDRG

N-Truncated Protein (5UTR-3CDS) Sequences

C-Truncated Protein (5CDS-3UTR) Sequences

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Personalized Fusion Protein Sequence for ROCK2_MEIS1

TCGA Kinase/DNA-binding Domain Mutated Fusion Protein Sequences

Num

Gene Group

Domain Loci

Fusion Protein ID

Fusion Gene Name

Partner

Mutated Residue in WT Protein

Seq. Length

Mutated Residue in Fusion Protein

CCLE Kinase/DNA-binding Domain Mutated Fusion Protein Sequences

Num

Gene Group

Domain Loci

Fusion Protein ID

Fusion Gene Name

Partner

Mutated Residue in WT Protein

Seq. Length

Mutated Residue in Fusion Protein

TCGA All Mutated Fusion Protein Sequences

>ROCK2_MEIS1_ENST00000315872_ENST00000272369_11484121_66775074_5-gene_p.A17S_216_A17S length=216AA
MSRPPPTGKMPGAPETSPGDGAGASRQRKLEALIRDPRSPINVESLLHPYPSEEQKKQLAQDTGLTILQVNNWFINARRRIVQPMIDQSNRAVSQGTPYNPDGQPMGGFVMDGQQHMGIRAPGLQSMPGEYVARGGPMGVSMGQPSYTQP
QMPPHPAQLRHGPPMHTYIPGHPHHPTVMMHGGPPHPGMPMSASSPTVLNTGDPTMSGQVMDIHAQ

>ROCK2_MEIS1_ENST00000315872_ENST00000272369_11484121_66775074_5-gene_p.V43E_216_V43E length=216AA
MSRPPPTGKMPGAPETAPGDGAGASRQRKLEALIRDPRSPINEESLLHPYPSEEQKKQLAQDTGLTILQVNNWFINARRRIVQPMIDQSNRAVSQGTPYNPDGQPMGGFVMDGQQHMGIRAPGLQSMPGEYVARGGPMGVSMGQPSYTQP
QMPPHPAQLRHGPPMHTYIPGHPHHPTVMMHGGPPHPGMPMSASSPTVLNTGDPTMSGQVMDIHAQ

>ROCK2_MEIS1_ENST00000315872_ENST00000272369_11484121_66775074_5-gene_p.P5S_216_P5S length=216AA
MSRPSPTGKMPGAPETAPGDGAGASRQRKLEALIRDPRSPINVESLLHPYPSEEQKKQLAQDTGLTILQVNNWFINARRRIVQPMIDQSNRAVSQGTPYNPDGQPMGGFVMDGQQHMGIRAPGLQSMPGEYVARGGPMGVSMGQPSYTQP
QMPPHPAQLRHGPPMHTYIPGHPHHPTVMMHGGPPHPGMPMSASSPTVLNTGDPTMSGQVMDIHAQ

>ROCK2_MEIS1_ENST00000315872_ENST00000272369_11484121_66775074_5-gene_p.E15K_216_E15K length=216AA
MSRPPPTGKMPGAPKTAPGDGAGASRQRKLEALIRDPRSPINVESLLHPYPSEEQKKQLAQDTGLTILQVNNWFINARRRIVQPMIDQSNRAVSQGTPYNPDGQPMGGFVMDGQQHMGIRAPGLQSMPGEYVARGGPMGVSMGQPSYTQP
QMPPHPAQLRHGPPMHTYIPGHPHHPTVMMHGGPPHPGMPMSASSPTVLNTGDPTMSGQVMDIHAQ

>ROCK2_MEIS1_ENST00000315872_ENST00000407092_11484121_66775074_5-gene_p.A17S_121_A17S length=121AA
MSRPPPTGKMPGAPETSPGDGAGASRQRKLEALIRDPRSPINVESLLHPYPSEEQKKQLAQDTGLTILQVNNWFINARRRIVQPMIDQSNRAGKSPIVTVFKSRKRKPSSSHSPGGPLPGK

>ROCK2_MEIS1_ENST00000315872_ENST00000407092_11484121_66775074_5-gene_p.V43E_121_V43E length=121AA
MSRPPPTGKMPGAPETAPGDGAGASRQRKLEALIRDPRSPINEESLLHPYPSEEQKKQLAQDTGLTILQVNNWFINARRRIVQPMIDQSNRAGKSPIVTVFKSRKRKPSSSHSPGGPLPGK

>ROCK2_MEIS1_ENST00000315872_ENST00000407092_11484121_66775074_5-gene_p.P5S_121_P5S length=121AA
MSRPSPTGKMPGAPETAPGDGAGASRQRKLEALIRDPRSPINVESLLHPYPSEEQKKQLAQDTGLTILQVNNWFINARRRIVQPMIDQSNRAGKSPIVTVFKSRKRKPSSSHSPGGPLPGK

>ROCK2_MEIS1_ENST00000315872_ENST00000407092_11484121_66775074_5-gene_p.E15K_121_E15K length=121AA
MSRPPPTGKMPGAPKTAPGDGAGASRQRKLEALIRDPRSPINVESLLHPYPSEEQKKQLAQDTGLTILQVNNWFINARRRIVQPMIDQSNRAGKSPIVTVFKSRKRKPSSSHSPGGPLPGK

>ROCK2_MEIS1_ENST00000315872_ENST00000444274_11484121_66775074_5-gene_p.A17S_216_A17S length=216AA
MSRPPPTGKMPGAPETSPGDGAGASRQRKLEALIRDPRSPINVESLLHPYPSEEQKKQLAQDTGLTILQVNNWFINARRRIVQPMIDQSNRAVSQGTPYNPDGQPMGGFVMDGQQHMGIRAPGLQSMPGEYVARGGPMGVSMGQPSYTQP
QMPPHPAQLRHGPPMHTYIPGHPHHPTVMMHGGPPHPGMPMSASSPTVLNTGDPTMSGQVMDIHAQ

>ROCK2_MEIS1_ENST00000315872_ENST00000444274_11484121_66775074_5-gene_p.V43E_216_V43E length=216AA
MSRPPPTGKMPGAPETAPGDGAGASRQRKLEALIRDPRSPINEESLLHPYPSEEQKKQLAQDTGLTILQVNNWFINARRRIVQPMIDQSNRAVSQGTPYNPDGQPMGGFVMDGQQHMGIRAPGLQSMPGEYVARGGPMGVSMGQPSYTQP
QMPPHPAQLRHGPPMHTYIPGHPHHPTVMMHGGPPHPGMPMSASSPTVLNTGDPTMSGQVMDIHAQ

>ROCK2_MEIS1_ENST00000315872_ENST00000444274_11484121_66775074_5-gene_p.P5S_216_P5S length=216AA
MSRPSPTGKMPGAPETAPGDGAGASRQRKLEALIRDPRSPINVESLLHPYPSEEQKKQLAQDTGLTILQVNNWFINARRRIVQPMIDQSNRAVSQGTPYNPDGQPMGGFVMDGQQHMGIRAPGLQSMPGEYVARGGPMGVSMGQPSYTQP
QMPPHPAQLRHGPPMHTYIPGHPHHPTVMMHGGPPHPGMPMSASSPTVLNTGDPTMSGQVMDIHAQ

>ROCK2_MEIS1_ENST00000315872_ENST00000444274_11484121_66775074_5-gene_p.E15K_216_E15K length=216AA
MSRPPPTGKMPGAPKTAPGDGAGASRQRKLEALIRDPRSPINVESLLHPYPSEEQKKQLAQDTGLTILQVNNWFINARRRIVQPMIDQSNRAVSQGTPYNPDGQPMGGFVMDGQQHMGIRAPGLQSMPGEYVARGGPMGVSMGQPSYTQP
QMPPHPAQLRHGPPMHTYIPGHPHHPTVMMHGGPPHPGMPMSASSPTVLNTGDPTMSGQVMDIHAQ

>ROCK2_MEIS1_ENST00000315872_ENST00000495021_11484121_66775074_5-gene_p.A17S_216_A17S length=216AA
MSRPPPTGKMPGAPETSPGDGAGASRQRKLEALIRDPRSPINVESLLHPYPSEEQKKQLAQDTGLTILQVNNWFINARRRIVQPMIDQSNRAVSQGTPYNPDGQPMGGFVMDGQQHMGIRAPGLQSMPGEYVARGGPMGVSMGQPSYTQP
QMPPHPAQLRHGPPMHTYIPGHPHHPTVMMHGGPPHPGMPMSASSPTVLNTGDPTMSGQVMDIHAQ

>ROCK2_MEIS1_ENST00000315872_ENST00000495021_11484121_66775074_5-gene_p.V43E_216_V43E length=216AA
MSRPPPTGKMPGAPETAPGDGAGASRQRKLEALIRDPRSPINEESLLHPYPSEEQKKQLAQDTGLTILQVNNWFINARRRIVQPMIDQSNRAVSQGTPYNPDGQPMGGFVMDGQQHMGIRAPGLQSMPGEYVARGGPMGVSMGQPSYTQP
QMPPHPAQLRHGPPMHTYIPGHPHHPTVMMHGGPPHPGMPMSASSPTVLNTGDPTMSGQVMDIHAQ

>ROCK2_MEIS1_ENST00000315872_ENST00000495021_11484121_66775074_5-gene_p.P5S_216_P5S length=216AA
MSRPSPTGKMPGAPETAPGDGAGASRQRKLEALIRDPRSPINVESLLHPYPSEEQKKQLAQDTGLTILQVNNWFINARRRIVQPMIDQSNRAVSQGTPYNPDGQPMGGFVMDGQQHMGIRAPGLQSMPGEYVARGGPMGVSMGQPSYTQP
QMPPHPAQLRHGPPMHTYIPGHPHHPTVMMHGGPPHPGMPMSASSPTVLNTGDPTMSGQVMDIHAQ

>ROCK2_MEIS1_ENST00000315872_ENST00000495021_11484121_66775074_5-gene_p.E15K_216_E15K length=216AA
MSRPPPTGKMPGAPKTAPGDGAGASRQRKLEALIRDPRSPINVESLLHPYPSEEQKKQLAQDTGLTILQVNNWFINARRRIVQPMIDQSNRAVSQGTPYNPDGQPMGGFVMDGQQHMGIRAPGLQSMPGEYVARGGPMGVSMGQPSYTQP
QMPPHPAQLRHGPPMHTYIPGHPHHPTVMMHGGPPHPGMPMSASSPTVLNTGDPTMSGQVMDIHAQ

Fusion Protein ID	Sample ID	Mutated Partner	AAchange in WT	Seq. Length	AAchange in Fusion
ENST00000315872_ENST00000272369_11484121_66775074	TCGA-05-4397-01A	5-gene	p.A17S	216	A17S
ENST00000315872_ENST00000272369_11484121_66775074	TCGA-49-4507-01A	5-gene	p.V43E	216	V43E
ENST00000315872_ENST00000272369_11484121_66775074	TCGA-49-6767-01A	5-gene	p.P5S	216	P5S
ENST00000315872_ENST00000272369_11484121_66775074	TCGA-D3-A8GP-06A	5-gene	p.E15K	216	E15K
ENST00000315872_ENST00000407092_11484121_66775074	TCGA-05-4397-01A	5-gene	p.A17S	121	A17S
ENST00000315872_ENST00000407092_11484121_66775074	TCGA-49-4507-01A	5-gene	p.V43E	121	V43E
ENST00000315872_ENST00000407092_11484121_66775074	TCGA-49-6767-01A	5-gene	p.P5S	121	P5S
ENST00000315872_ENST00000407092_11484121_66775074	TCGA-D3-A8GP-06A	5-gene	p.E15K	121	E15K
ENST00000315872_ENST00000444274_11484121_66775074	TCGA-05-4397-01A	5-gene	p.A17S	216	A17S
ENST00000315872_ENST00000444274_11484121_66775074	TCGA-49-4507-01A	5-gene	p.V43E	216	V43E
ENST00000315872_ENST00000444274_11484121_66775074	TCGA-49-6767-01A	5-gene	p.P5S	216	P5S
ENST00000315872_ENST00000444274_11484121_66775074	TCGA-D3-A8GP-06A	5-gene	p.E15K	216	E15K
ENST00000315872_ENST00000495021_11484121_66775074	TCGA-05-4397-01A	5-gene	p.A17S	216	A17S
ENST00000315872_ENST00000495021_11484121_66775074	TCGA-49-4507-01A	5-gene	p.V43E	216	V43E
ENST00000315872_ENST00000495021_11484121_66775074	TCGA-49-6767-01A	5-gene	p.P5S	216	P5S
ENST00000315872_ENST00000495021_11484121_66775074	TCGA-D3-A8GP-06A	5-gene	p.E15K	216	E15K

CCLE All Mutated Fusion Protein Sequences

Fusion Protein ID

Sample ID

Mutated Partner

AAchange in WT

Seq. Length

AAchange in Fusion

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Fusion Gene Exprssed Samples for ROCK2_MEIS1

RNA-seq based fusion gene expressed samples.

Source	Study	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB		OV	TCGA-29-1691-01A	ROCK2	chr2	11484121	-	MEIS1	chr2	11484121	+
ChimerDB		OV	TCGA-29-1691	ROCK2	chr2	11484121	-	MEIS1	chr2	11484121	+
WashU		OV	TCGA-29-1691-01A	ROCK2	chr2	11484122	-	MEIS1	chr2	66775075	+

DNA-seq based fusion gene expressed samples.

Source

Study

Disease

Sample

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

SV type

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Related Drugs for ROCK2_MEIS1

PubMed Abstract Search With ['A-B' AND 'drug'], ['A::B' AND 'drug']
* For more details on the Studied, Reported, Approved Drugs targeting this fusion gene, Go to FusionPub.

PMID

Fusion Gene Name

Drug

Study Title

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status