Fusion Gene Studies
in Kim Lab

FusionBase FusionGDB FusionGDB2 FusionPDB FusionNeoAntigen FusionAI FusionNW FGviewer Publication Contact
FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:AKT3-ADSS (FusionGDB2 ID:HG10000TG159)

Fusion Gene Summary for AKT3-ADSS

check button Fusion gene summary
Fusion gene informationFusion gene name: AKT3-ADSS
Fusion gene ID: hg10000tg159
HgeneTgene
Gene symbol

AKT3

ADSS

Gene ID

10000

159

Gene nameAKT serine/threonine kinase 3adenylosuccinate synthase 2
SynonymsMPPH|MPPH2|PKB-GAMMA|PKBG|PRKBG|RAC-PK-gamma|RAC-gamma|STK-2ADEH|ADSS|ADSS 2
Cytomap('AKT3')('ADSS')

1q43-q44

1q44

Type of geneprotein-codingprotein-coding
DescriptionRAC-gamma serine/threonine-protein kinasePKB gammaRAC-gamma serine/threonine protein kinasev-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma)adenylosuccinate synthetase isozyme 2AMPSase 2IMP--aspartate ligase 2L-type adenylosuccinate synthetaseadSS 2adenylosuccinate synthetase (Ade(-)H-complementing)adenylosuccinate synthetase, acidic isozymeadenylosuccinate synthetase, liver isozymeep
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000263826, ENST00000336199, 
ENST00000366539, ENST00000366540, 
ENST00000492957, 
Fusion gene scores* DoF score18 X 15 X 7=189010 X 5 X 6=300
# samples 2112
** MAII scorelog2(21/1890*10)=-3.16992500144231
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(12/300*10)=-1.32192809488736
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: AKT3 [Title/Abstract] AND ADSS [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointAKT3(244006427)-ADSS(244601070), # samples:3
Anticipated loss of major functional domain due to fusion event.AKT3-ADSS seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
AKT3-ADSS seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
AKT3-ADSS seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
AKT3-ADSS seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
AKT3-ADSS seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
AKT3-ADSS seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
AKT3-ADSS seems lost the major protein functional domain in Hgene partner, which is a kinase due to the frame-shifted ORF.
AKT3-ADSS seems lost the major protein functional domain in Tgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
AKT3-ADSS seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneAKT3

GO:0043536

positive regulation of blood vessel endothelial cell migration

28254819

HgeneAKT3

GO:1905564

positive regulation of vascular endothelial cell proliferation

28254819

TgeneADSS

GO:0006167

AMP biosynthetic process

2004783


check buttonFusion gene breakpoints across AKT3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across ADSS (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4PRADTCGA-ZG-A9KY-01AAKT3chr1

244006427

-ADSSchr1

244601070

-
ChimerDB4PRADTCGA-ZG-A9KYAKT3chr1

244006426

-ADSSchr1

244601070

-
ChimerDB4PRADTCGA-ZG-A9KYAKT3chr1

244006427

-ADSSchr1

244601070

-


Top

Fusion Gene ORF analysis for AKT3-ADSS

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000263826ENST00000462358AKT3chr1

244006427

-ADSSchr1

244601070

-
5CDS-intronENST00000263826ENST00000462358AKT3chr1

244006426

-ADSSchr1

244601070

-
5CDS-intronENST00000336199ENST00000462358AKT3chr1

244006427

-ADSSchr1

244601070

-
5CDS-intronENST00000336199ENST00000462358AKT3chr1

244006426

-ADSSchr1

244601070

-
5CDS-intronENST00000366539ENST00000462358AKT3chr1

244006427

-ADSSchr1

244601070

-
5CDS-intronENST00000366539ENST00000462358AKT3chr1

244006426

-ADSSchr1

244601070

-
5CDS-intronENST00000366540ENST00000462358AKT3chr1

244006427

-ADSSchr1

244601070

-
5CDS-intronENST00000366540ENST00000462358AKT3chr1

244006426

-ADSSchr1

244601070

-
Frame-shiftENST00000366540ENST00000366535AKT3chr1

244006427

-ADSSchr1

244601070

-
Frame-shiftENST00000366540ENST00000366535AKT3chr1

244006426

-ADSSchr1

244601070

-
In-frameENST00000263826ENST00000366535AKT3chr1

244006427

-ADSSchr1

244601070

-
In-frameENST00000263826ENST00000366535AKT3chr1

244006426

-ADSSchr1

244601070

-
In-frameENST00000336199ENST00000366535AKT3chr1

244006427

-ADSSchr1

244601070

-
In-frameENST00000336199ENST00000366535AKT3chr1

244006426

-ADSSchr1

244601070

-
In-frameENST00000366539ENST00000366535AKT3chr1

244006427

-ADSSchr1

244601070

-
In-frameENST00000366539ENST00000366535AKT3chr1

244006426

-ADSSchr1

244601070

-
intron-3CDSENST00000492957ENST00000366535AKT3chr1

244006427

-ADSSchr1

244601070

-
intron-3CDSENST00000492957ENST00000366535AKT3chr1

244006426

-ADSSchr1

244601070

-
intron-intronENST00000492957ENST00000462358AKT3chr1

244006427

-ADSSchr1

244601070

-
intron-intronENST00000492957ENST00000462358AKT3chr1

244006426

-ADSSchr1

244601070

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000336199AKT3chr1244006427-ENST00000366535ADSSchr1244601070-23921122441299351
ENST00000366539AKT3chr1244006427-ENST00000366535ADSSchr1244601070-25272473791434351
ENST00000263826AKT3chr1244006427-ENST00000366535ADSSchr1244601070-24071272591314351
ENST00000336199AKT3chr1244006426-ENST00000366535ADSSchr1244601070-23921122441299351
ENST00000366539AKT3chr1244006426-ENST00000366535ADSSchr1244601070-25272473791434351
ENST00000263826AKT3chr1244006426-ENST00000366535ADSSchr1244601070-24071272591314351

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000336199ENST00000366535AKT3chr1244006427-ADSSchr1244601070-0.0003972450.99960274
ENST00000366539ENST00000366535AKT3chr1244006427-ADSSchr1244601070-0.0004926130.9995074
ENST00000263826ENST00000366535AKT3chr1244006427-ADSSchr1244601070-0.0004647670.9995352
ENST00000336199ENST00000366535AKT3chr1244006426-ADSSchr1244601070-0.0003972450.99960274
ENST00000366539ENST00000366535AKT3chr1244006426-ADSSchr1244601070-0.0004926130.9995074
ENST00000263826ENST00000366535AKT3chr1244006426-ADSSchr1244601070-0.0004647670.9995352

Top

Fusion Genomic Features for AKT3-ADSS


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

Top

Fusion Protein Features for AKT3-ADSS


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:244006427/chr1:244601070)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneADSSchr1:244006426chr1:244601070ENST00000366535013362_36461457.0Nucleotide bindingNote=GTP
TgeneADSSchr1:244006426chr1:244601070ENST00000366535013444_44761457.0Nucleotide bindingNote=GTP
TgeneADSSchr1:244006426chr1:244601070ENST0000036653501367_6961457.0Nucleotide bindingNote=GTP
TgeneADSSchr1:244006427chr1:244601070ENST00000366535013362_36461457.0Nucleotide bindingNote=GTP
TgeneADSSchr1:244006427chr1:244601070ENST00000366535013444_44761457.0Nucleotide bindingNote=GTP
TgeneADSSchr1:244006427chr1:244601070ENST0000036653501367_6961457.0Nucleotide bindingNote=GTP
TgeneADSSchr1:244006426chr1:244601070ENST00000366535013330_33661457.0RegionSubstrate binding
TgeneADSSchr1:244006426chr1:244601070ENST0000036653501365_6861457.0RegionIMP binding
TgeneADSSchr1:244006427chr1:244601070ENST00000366535013330_33661457.0RegionSubstrate binding
TgeneADSSchr1:244006427chr1:244601070ENST0000036653501365_6861457.0RegionIMP binding

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneAKT3chr1:244006426chr1:244601070ENST00000263826-113148_40515480.0DomainProtein kinase
HgeneAKT3chr1:244006426chr1:244601070ENST00000263826-113406_47915480.0DomainAGC-kinase C-terminal
HgeneAKT3chr1:244006426chr1:244601070ENST00000263826-1135_10715480.0DomainPH
HgeneAKT3chr1:244006426chr1:244601070ENST00000336199-114148_40515476.0DomainProtein kinase
HgeneAKT3chr1:244006426chr1:244601070ENST00000336199-114406_47915476.0DomainAGC-kinase C-terminal
HgeneAKT3chr1:244006426chr1:244601070ENST00000336199-1145_10715476.0DomainPH
HgeneAKT3chr1:244006426chr1:244601070ENST00000366539-214148_40515480.0DomainProtein kinase
HgeneAKT3chr1:244006426chr1:244601070ENST00000366539-214406_47915480.0DomainAGC-kinase C-terminal
HgeneAKT3chr1:244006426chr1:244601070ENST00000366539-2145_10715480.0DomainPH
HgeneAKT3chr1:244006426chr1:244601070ENST00000366540-214148_40515466.0DomainProtein kinase
HgeneAKT3chr1:244006426chr1:244601070ENST00000366540-214406_47915466.0DomainAGC-kinase C-terminal
HgeneAKT3chr1:244006426chr1:244601070ENST00000366540-2145_10715466.0DomainPH
HgeneAKT3chr1:244006427chr1:244601070ENST00000263826-113148_40515480.0DomainProtein kinase
HgeneAKT3chr1:244006427chr1:244601070ENST00000263826-113406_47915480.0DomainAGC-kinase C-terminal
HgeneAKT3chr1:244006427chr1:244601070ENST00000263826-1135_10715480.0DomainPH
HgeneAKT3chr1:244006427chr1:244601070ENST00000336199-114148_40515476.0DomainProtein kinase
HgeneAKT3chr1:244006427chr1:244601070ENST00000336199-114406_47915476.0DomainAGC-kinase C-terminal
HgeneAKT3chr1:244006427chr1:244601070ENST00000336199-1145_10715476.0DomainPH
HgeneAKT3chr1:244006427chr1:244601070ENST00000366539-214148_40515480.0DomainProtein kinase
HgeneAKT3chr1:244006427chr1:244601070ENST00000366539-214406_47915480.0DomainAGC-kinase C-terminal
HgeneAKT3chr1:244006427chr1:244601070ENST00000366539-2145_10715480.0DomainPH
HgeneAKT3chr1:244006427chr1:244601070ENST00000366540-214148_40515466.0DomainProtein kinase
HgeneAKT3chr1:244006427chr1:244601070ENST00000366540-214406_47915466.0DomainAGC-kinase C-terminal
HgeneAKT3chr1:244006427chr1:244601070ENST00000366540-2145_10715466.0DomainPH
HgeneAKT3chr1:244006426chr1:244601070ENST00000263826-113154_16215480.0Nucleotide bindingATP
HgeneAKT3chr1:244006426chr1:244601070ENST00000336199-114154_16215476.0Nucleotide bindingATP
HgeneAKT3chr1:244006426chr1:244601070ENST00000366539-214154_16215480.0Nucleotide bindingATP
HgeneAKT3chr1:244006426chr1:244601070ENST00000366540-214154_16215466.0Nucleotide bindingATP
HgeneAKT3chr1:244006427chr1:244601070ENST00000263826-113154_16215480.0Nucleotide bindingATP
HgeneAKT3chr1:244006427chr1:244601070ENST00000336199-114154_16215476.0Nucleotide bindingATP
HgeneAKT3chr1:244006427chr1:244601070ENST00000366539-214154_16215480.0Nucleotide bindingATP
HgeneAKT3chr1:244006427chr1:244601070ENST00000366540-214154_16215466.0Nucleotide bindingATP
TgeneADSSchr1:244006426chr1:244601070ENST0000036653501339_4561457.0Nucleotide bindingNote=GTP
TgeneADSSchr1:244006427chr1:244601070ENST0000036653501339_4561457.0Nucleotide bindingNote=GTP
TgeneADSSchr1:244006426chr1:244601070ENST0000036653501340_4361457.0RegionIMP binding
TgeneADSSchr1:244006427chr1:244601070ENST0000036653501340_4361457.0RegionIMP binding


Top

Fusion Gene Sequence for AKT3-ADSS


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>3490_3490_1_AKT3-ADSS_AKT3_chr1_244006426_ENST00000263826_ADSS_chr1_244601070_ENST00000366535_length(transcript)=2407nt_BP=127nt
GCAGCAGCAGAGAATCCAAACCCTAAAGCTGATATCACAAAGTACCATTTCTCCAAGTTGGGGGCTCAGAGGGGAGTCATCATGAGCGAT
GTTACCATTGTGAAAGAAGGTTGGGTTCAGAAGAGGGGGAGGAAATAATGCTGGCCATACAGTTGTTGTGGATTCTGTGGAATATGATTT
TCATCTCTTACCCAGTGGAATAATTAATCCAAATGTCACTGCATTCATTGGAAATGGTGTGGTAATTCATCTACCTGGATTGTTTGAAGA
AGCAGAGAAAAATGTTCAAAAAGGAAAAGGACTAGAAGGCTGGGAAAAAAGGCTTATTATATCTGACAGAGCTCATATTGTATTTGATTT
TCATCAAGCAGCTGATGGTATCCAGGAACAACAGAGACAAGAACAAGCAGGAAAAAATTTGGGTACAACAAAAAAGGGCATTGGCCCAGT
TTATTCGTCCAAAGCTGCTCGGAGTGGACTCAGGATGTGCGACCTTGTTTCTGACTTTGATGGCTTCTCTGAGAGGTTTAAAGTTCTAGC
TAACCAATACAAATCTATATACCCCACTTTGGAAATAGACATTGAAGGTGAATTACAAAAACTCAAGGGTTATATGGAAAAGATTAAACC
AATGGTGAGAGATGGAGTTTATTTTCTATATGAGGCCCTACATGGACCACCAAAGAAAATCTTGGTAGAAGGTGCAAATGCAGCACTATT
AGATATTGATTTTGGGACTTACCCTTTTGTAACCTCTTCAAATTGTACTGTTGGAGGTGTTTGTACTGGTTTGGGTATGCCACCTCAAAA
TGTTGGAGAAGTGTATGGAGTTGTGAAAGCTTATACAACTAGAGTTGGTATTGGTGCCTTTCCTACAGAGCAAGACAATGAAATTGGAGA
ATTATTACAAACAAGGGGTAGAGAGTTTGGTGTAACTACTGGAAGGAAAAGAAGATGTGGCTGGTTGGACCTCGTTTTGCTCAAATATGC
TCATATGATCAATGGATTTACTGCGTTGGCACTTACCAAGTTGGATATTTTGGACATGTTTACGGAAATCAAAGTTGGAGTTGCTTACAA
GTTAGATGGTGAAATCATACCTCATATCCCAGCAAACCAAGAAGTCTTAAATAAAGTTGAAGTTCAATATAAGACTCTCCCAGGATGGAA
CACAGACATATCAAATGCAAGGGCGTTTAAAGAACTACCTGTTAATGCACAAAACTATGTTCGATTTATTGAAGATGAGCTTCAAATTCC
AGTTAAGTGGATTGGTGTTGGTAAATCCAGAGAATCTATGATTCAACTCTTTTAATGATTGCCAGTAATGCAAGAAACACTCCTTGAGAG
GGAGGGGAAAAGACTTTCTTAAATATTTCATTTATGACCTGCAAATTCAAGAATAAAGACACTGAAGTAAGTTTGAAGCCCTACAGTTGT
TTCCAGTCTTTTCAGATGGATGCCTACTGTGGAGATTAACTTTGGCATATTCCAGTGTCAGCTTTCTTTAGCTGGAATTGCCAAATCATT
TGTTGCTCCTGCTGCTCTCATGGTGCCACGTTTTTTTTTTCAATGTTTAGTAATAGTATAATCCATGTTGTTTGATATCAAAAGTAGAAT
TACTTTTAATGTAGTTTTTCTTCATTATTGTCATTGCGTGTTCTTAAGTTTTACCCCTATTAGATGGTAAGAACAATTAATGCAGTTTTG
CACAAATATTTTTACATTCTGATCATTCAGTTCTGTCATTGTAATCTTTGTTGTTAGAAACAAATGATGAAAACATAGGGGTTCTGTAAA
CTTTTGTAATGCTATGAATTCTGTTTAAATTTTGGGCTGTCTATTTTCTGCTGAAACCATGCAAAATTGAGCTTTGGTGGGGCTGGGAGG
GGGTTATGTATTCATGGGACCTTTAATTTGTACAGAACACAGAACTTATTTCTGTCAGTTATTTAATACATTGAAAATTTAGTGAAATGT
TCAAAGAGAATAGATGTTTCCCAAAACAACAATCTTTATGTTAAAAATAGTCATTAAAAGATCTGTTGTAATATATGGTGGATATTTTTC
TTTAATTTCAAACATTACCTCTGAAATGTGTATCTTTTCTTTTTTATCTTACCATTAATTTTAAATCTAGTGGATTGGTTTTCAACATCG
TGCCTGCCGATATGCCTACAGAATCATCTGTAAGTGTCAAAATGAACCCACGTTGTTAGCCATAATTTTGATTATGCCTTTATTTCTCCT
TTCTTGAAAAAAAAAAGGTGTTATTTTGACAATTAGGCATAACATTGTTTTGTAGATTATCTTTTAATGAACTATTTTAAATGTTAAATT

>3490_3490_1_AKT3-ADSS_AKT3_chr1_244006426_ENST00000263826_ADSS_chr1_244601070_ENST00000366535_length(amino acids)=351AA_BP=
MFEEAEKNVQKGKGLEGWEKRLIISDRAHIVFDFHQAADGIQEQQRQEQAGKNLGTTKKGIGPVYSSKAARSGLRMCDLVSDFDGFSERF
KVLANQYKSIYPTLEIDIEGELQKLKGYMEKIKPMVRDGVYFLYEALHGPPKKILVEGANAALLDIDFGTYPFVTSSNCTVGGVCTGLGM
PPQNVGEVYGVVKAYTTRVGIGAFPTEQDNEIGELLQTRGREFGVTTGRKRRCGWLDLVLLKYAHMINGFTALALTKLDILDMFTEIKVG

--------------------------------------------------------------
>3490_3490_2_AKT3-ADSS_AKT3_chr1_244006426_ENST00000336199_ADSS_chr1_244601070_ENST00000366535_length(transcript)=2392nt_BP=112nt
CCAAACCCTAAAGCTGATATCACAAAGTACCATTTCTCCAAGTTGGGGGCTCAGAGGGGAGTCATCATGAGCGATGTTACCATTGTGAAA
GAAGGTTGGGTTCAGAAGAGGGGGAGGAAATAATGCTGGCCATACAGTTGTTGTGGATTCTGTGGAATATGATTTTCATCTCTTACCCAG
TGGAATAATTAATCCAAATGTCACTGCATTCATTGGAAATGGTGTGGTAATTCATCTACCTGGATTGTTTGAAGAAGCAGAGAAAAATGT
TCAAAAAGGAAAAGGACTAGAAGGCTGGGAAAAAAGGCTTATTATATCTGACAGAGCTCATATTGTATTTGATTTTCATCAAGCAGCTGA
TGGTATCCAGGAACAACAGAGACAAGAACAAGCAGGAAAAAATTTGGGTACAACAAAAAAGGGCATTGGCCCAGTTTATTCGTCCAAAGC
TGCTCGGAGTGGACTCAGGATGTGCGACCTTGTTTCTGACTTTGATGGCTTCTCTGAGAGGTTTAAAGTTCTAGCTAACCAATACAAATC
TATATACCCCACTTTGGAAATAGACATTGAAGGTGAATTACAAAAACTCAAGGGTTATATGGAAAAGATTAAACCAATGGTGAGAGATGG
AGTTTATTTTCTATATGAGGCCCTACATGGACCACCAAAGAAAATCTTGGTAGAAGGTGCAAATGCAGCACTATTAGATATTGATTTTGG
GACTTACCCTTTTGTAACCTCTTCAAATTGTACTGTTGGAGGTGTTTGTACTGGTTTGGGTATGCCACCTCAAAATGTTGGAGAAGTGTA
TGGAGTTGTGAAAGCTTATACAACTAGAGTTGGTATTGGTGCCTTTCCTACAGAGCAAGACAATGAAATTGGAGAATTATTACAAACAAG
GGGTAGAGAGTTTGGTGTAACTACTGGAAGGAAAAGAAGATGTGGCTGGTTGGACCTCGTTTTGCTCAAATATGCTCATATGATCAATGG
ATTTACTGCGTTGGCACTTACCAAGTTGGATATTTTGGACATGTTTACGGAAATCAAAGTTGGAGTTGCTTACAAGTTAGATGGTGAAAT
CATACCTCATATCCCAGCAAACCAAGAAGTCTTAAATAAAGTTGAAGTTCAATATAAGACTCTCCCAGGATGGAACACAGACATATCAAA
TGCAAGGGCGTTTAAAGAACTACCTGTTAATGCACAAAACTATGTTCGATTTATTGAAGATGAGCTTCAAATTCCAGTTAAGTGGATTGG
TGTTGGTAAATCCAGAGAATCTATGATTCAACTCTTTTAATGATTGCCAGTAATGCAAGAAACACTCCTTGAGAGGGAGGGGAAAAGACT
TTCTTAAATATTTCATTTATGACCTGCAAATTCAAGAATAAAGACACTGAAGTAAGTTTGAAGCCCTACAGTTGTTTCCAGTCTTTTCAG
ATGGATGCCTACTGTGGAGATTAACTTTGGCATATTCCAGTGTCAGCTTTCTTTAGCTGGAATTGCCAAATCATTTGTTGCTCCTGCTGC
TCTCATGGTGCCACGTTTTTTTTTTCAATGTTTAGTAATAGTATAATCCATGTTGTTTGATATCAAAAGTAGAATTACTTTTAATGTAGT
TTTTCTTCATTATTGTCATTGCGTGTTCTTAAGTTTTACCCCTATTAGATGGTAAGAACAATTAATGCAGTTTTGCACAAATATTTTTAC
ATTCTGATCATTCAGTTCTGTCATTGTAATCTTTGTTGTTAGAAACAAATGATGAAAACATAGGGGTTCTGTAAACTTTTGTAATGCTAT
GAATTCTGTTTAAATTTTGGGCTGTCTATTTTCTGCTGAAACCATGCAAAATTGAGCTTTGGTGGGGCTGGGAGGGGGTTATGTATTCAT
GGGACCTTTAATTTGTACAGAACACAGAACTTATTTCTGTCAGTTATTTAATACATTGAAAATTTAGTGAAATGTTCAAAGAGAATAGAT
GTTTCCCAAAACAACAATCTTTATGTTAAAAATAGTCATTAAAAGATCTGTTGTAATATATGGTGGATATTTTTCTTTAATTTCAAACAT
TACCTCTGAAATGTGTATCTTTTCTTTTTTATCTTACCATTAATTTTAAATCTAGTGGATTGGTTTTCAACATCGTGCCTGCCGATATGC
CTACAGAATCATCTGTAAGTGTCAAAATGAACCCACGTTGTTAGCCATAATTTTGATTATGCCTTTATTTCTCCTTTCTTGAAAAAAAAA
AGGTGTTATTTTGACAATTAGGCATAACATTGTTTTGTAGATTATCTTTTAATGAACTATTTTAAATGTTAAATTAGGTGCCACTTAAAT

>3490_3490_2_AKT3-ADSS_AKT3_chr1_244006426_ENST00000336199_ADSS_chr1_244601070_ENST00000366535_length(amino acids)=351AA_BP=
MFEEAEKNVQKGKGLEGWEKRLIISDRAHIVFDFHQAADGIQEQQRQEQAGKNLGTTKKGIGPVYSSKAARSGLRMCDLVSDFDGFSERF
KVLANQYKSIYPTLEIDIEGELQKLKGYMEKIKPMVRDGVYFLYEALHGPPKKILVEGANAALLDIDFGTYPFVTSSNCTVGGVCTGLGM
PPQNVGEVYGVVKAYTTRVGIGAFPTEQDNEIGELLQTRGREFGVTTGRKRRCGWLDLVLLKYAHMINGFTALALTKLDILDMFTEIKVG

--------------------------------------------------------------
>3490_3490_3_AKT3-ADSS_AKT3_chr1_244006426_ENST00000366539_ADSS_chr1_244601070_ENST00000366535_length(transcript)=2527nt_BP=247nt
CCCTCTCCTCCCCCCGCCCCCCCCCGGCTCCATCCTCCGCCGCCGCCCGAGCAGCTGCGGGGCCGCCACCGCCGCCGCCGCCGTTGCAGG
CTGAGTCATCACTAGAGAGTGGGAAGGGCAGCAGCAGCAGAGAATCCAAACCCTAAAGCTGATATCACAAAGTACCATTTCTCCAAGTTG
GGGGCTCAGAGGGGAGTCATCATGAGCGATGTTACCATTGTGAAAGAAGGTTGGGTTCAGAAGAGGGGGAGGAAATAATGCTGGCCATAC
AGTTGTTGTGGATTCTGTGGAATATGATTTTCATCTCTTACCCAGTGGAATAATTAATCCAAATGTCACTGCATTCATTGGAAATGGTGT
GGTAATTCATCTACCTGGATTGTTTGAAGAAGCAGAGAAAAATGTTCAAAAAGGAAAAGGACTAGAAGGCTGGGAAAAAAGGCTTATTAT
ATCTGACAGAGCTCATATTGTATTTGATTTTCATCAAGCAGCTGATGGTATCCAGGAACAACAGAGACAAGAACAAGCAGGAAAAAATTT
GGGTACAACAAAAAAGGGCATTGGCCCAGTTTATTCGTCCAAAGCTGCTCGGAGTGGACTCAGGATGTGCGACCTTGTTTCTGACTTTGA
TGGCTTCTCTGAGAGGTTTAAAGTTCTAGCTAACCAATACAAATCTATATACCCCACTTTGGAAATAGACATTGAAGGTGAATTACAAAA
ACTCAAGGGTTATATGGAAAAGATTAAACCAATGGTGAGAGATGGAGTTTATTTTCTATATGAGGCCCTACATGGACCACCAAAGAAAAT
CTTGGTAGAAGGTGCAAATGCAGCACTATTAGATATTGATTTTGGGACTTACCCTTTTGTAACCTCTTCAAATTGTACTGTTGGAGGTGT
TTGTACTGGTTTGGGTATGCCACCTCAAAATGTTGGAGAAGTGTATGGAGTTGTGAAAGCTTATACAACTAGAGTTGGTATTGGTGCCTT
TCCTACAGAGCAAGACAATGAAATTGGAGAATTATTACAAACAAGGGGTAGAGAGTTTGGTGTAACTACTGGAAGGAAAAGAAGATGTGG
CTGGTTGGACCTCGTTTTGCTCAAATATGCTCATATGATCAATGGATTTACTGCGTTGGCACTTACCAAGTTGGATATTTTGGACATGTT
TACGGAAATCAAAGTTGGAGTTGCTTACAAGTTAGATGGTGAAATCATACCTCATATCCCAGCAAACCAAGAAGTCTTAAATAAAGTTGA
AGTTCAATATAAGACTCTCCCAGGATGGAACACAGACATATCAAATGCAAGGGCGTTTAAAGAACTACCTGTTAATGCACAAAACTATGT
TCGATTTATTGAAGATGAGCTTCAAATTCCAGTTAAGTGGATTGGTGTTGGTAAATCCAGAGAATCTATGATTCAACTCTTTTAATGATT
GCCAGTAATGCAAGAAACACTCCTTGAGAGGGAGGGGAAAAGACTTTCTTAAATATTTCATTTATGACCTGCAAATTCAAGAATAAAGAC
ACTGAAGTAAGTTTGAAGCCCTACAGTTGTTTCCAGTCTTTTCAGATGGATGCCTACTGTGGAGATTAACTTTGGCATATTCCAGTGTCA
GCTTTCTTTAGCTGGAATTGCCAAATCATTTGTTGCTCCTGCTGCTCTCATGGTGCCACGTTTTTTTTTTCAATGTTTAGTAATAGTATA
ATCCATGTTGTTTGATATCAAAAGTAGAATTACTTTTAATGTAGTTTTTCTTCATTATTGTCATTGCGTGTTCTTAAGTTTTACCCCTAT
TAGATGGTAAGAACAATTAATGCAGTTTTGCACAAATATTTTTACATTCTGATCATTCAGTTCTGTCATTGTAATCTTTGTTGTTAGAAA
CAAATGATGAAAACATAGGGGTTCTGTAAACTTTTGTAATGCTATGAATTCTGTTTAAATTTTGGGCTGTCTATTTTCTGCTGAAACCAT
GCAAAATTGAGCTTTGGTGGGGCTGGGAGGGGGTTATGTATTCATGGGACCTTTAATTTGTACAGAACACAGAACTTATTTCTGTCAGTT
ATTTAATACATTGAAAATTTAGTGAAATGTTCAAAGAGAATAGATGTTTCCCAAAACAACAATCTTTATGTTAAAAATAGTCATTAAAAG
ATCTGTTGTAATATATGGTGGATATTTTTCTTTAATTTCAAACATTACCTCTGAAATGTGTATCTTTTCTTTTTTATCTTACCATTAATT
TTAAATCTAGTGGATTGGTTTTCAACATCGTGCCTGCCGATATGCCTACAGAATCATCTGTAAGTGTCAAAATGAACCCACGTTGTTAGC
CATAATTTTGATTATGCCTTTATTTCTCCTTTCTTGAAAAAAAAAAGGTGTTATTTTGACAATTAGGCATAACATTGTTTTGTAGATTAT
CTTTTAATGAACTATTTTAAATGTTAAATTAGGTGCCACTTAAATTTATTTTATTACACCATGAATAGCTGATTAAAAGAACCAAATATT

>3490_3490_3_AKT3-ADSS_AKT3_chr1_244006426_ENST00000366539_ADSS_chr1_244601070_ENST00000366535_length(amino acids)=351AA_BP=
MFEEAEKNVQKGKGLEGWEKRLIISDRAHIVFDFHQAADGIQEQQRQEQAGKNLGTTKKGIGPVYSSKAARSGLRMCDLVSDFDGFSERF
KVLANQYKSIYPTLEIDIEGELQKLKGYMEKIKPMVRDGVYFLYEALHGPPKKILVEGANAALLDIDFGTYPFVTSSNCTVGGVCTGLGM
PPQNVGEVYGVVKAYTTRVGIGAFPTEQDNEIGELLQTRGREFGVTTGRKRRCGWLDLVLLKYAHMINGFTALALTKLDILDMFTEIKVG

--------------------------------------------------------------
>3490_3490_4_AKT3-ADSS_AKT3_chr1_244006427_ENST00000263826_ADSS_chr1_244601070_ENST00000366535_length(transcript)=2407nt_BP=127nt
GCAGCAGCAGAGAATCCAAACCCTAAAGCTGATATCACAAAGTACCATTTCTCCAAGTTGGGGGCTCAGAGGGGAGTCATCATGAGCGAT
GTTACCATTGTGAAAGAAGGTTGGGTTCAGAAGAGGGGGAGGAAATAATGCTGGCCATACAGTTGTTGTGGATTCTGTGGAATATGATTT
TCATCTCTTACCCAGTGGAATAATTAATCCAAATGTCACTGCATTCATTGGAAATGGTGTGGTAATTCATCTACCTGGATTGTTTGAAGA
AGCAGAGAAAAATGTTCAAAAAGGAAAAGGACTAGAAGGCTGGGAAAAAAGGCTTATTATATCTGACAGAGCTCATATTGTATTTGATTT
TCATCAAGCAGCTGATGGTATCCAGGAACAACAGAGACAAGAACAAGCAGGAAAAAATTTGGGTACAACAAAAAAGGGCATTGGCCCAGT
TTATTCGTCCAAAGCTGCTCGGAGTGGACTCAGGATGTGCGACCTTGTTTCTGACTTTGATGGCTTCTCTGAGAGGTTTAAAGTTCTAGC
TAACCAATACAAATCTATATACCCCACTTTGGAAATAGACATTGAAGGTGAATTACAAAAACTCAAGGGTTATATGGAAAAGATTAAACC
AATGGTGAGAGATGGAGTTTATTTTCTATATGAGGCCCTACATGGACCACCAAAGAAAATCTTGGTAGAAGGTGCAAATGCAGCACTATT
AGATATTGATTTTGGGACTTACCCTTTTGTAACCTCTTCAAATTGTACTGTTGGAGGTGTTTGTACTGGTTTGGGTATGCCACCTCAAAA
TGTTGGAGAAGTGTATGGAGTTGTGAAAGCTTATACAACTAGAGTTGGTATTGGTGCCTTTCCTACAGAGCAAGACAATGAAATTGGAGA
ATTATTACAAACAAGGGGTAGAGAGTTTGGTGTAACTACTGGAAGGAAAAGAAGATGTGGCTGGTTGGACCTCGTTTTGCTCAAATATGC
TCATATGATCAATGGATTTACTGCGTTGGCACTTACCAAGTTGGATATTTTGGACATGTTTACGGAAATCAAAGTTGGAGTTGCTTACAA
GTTAGATGGTGAAATCATACCTCATATCCCAGCAAACCAAGAAGTCTTAAATAAAGTTGAAGTTCAATATAAGACTCTCCCAGGATGGAA
CACAGACATATCAAATGCAAGGGCGTTTAAAGAACTACCTGTTAATGCACAAAACTATGTTCGATTTATTGAAGATGAGCTTCAAATTCC
AGTTAAGTGGATTGGTGTTGGTAAATCCAGAGAATCTATGATTCAACTCTTTTAATGATTGCCAGTAATGCAAGAAACACTCCTTGAGAG
GGAGGGGAAAAGACTTTCTTAAATATTTCATTTATGACCTGCAAATTCAAGAATAAAGACACTGAAGTAAGTTTGAAGCCCTACAGTTGT
TTCCAGTCTTTTCAGATGGATGCCTACTGTGGAGATTAACTTTGGCATATTCCAGTGTCAGCTTTCTTTAGCTGGAATTGCCAAATCATT
TGTTGCTCCTGCTGCTCTCATGGTGCCACGTTTTTTTTTTCAATGTTTAGTAATAGTATAATCCATGTTGTTTGATATCAAAAGTAGAAT
TACTTTTAATGTAGTTTTTCTTCATTATTGTCATTGCGTGTTCTTAAGTTTTACCCCTATTAGATGGTAAGAACAATTAATGCAGTTTTG
CACAAATATTTTTACATTCTGATCATTCAGTTCTGTCATTGTAATCTTTGTTGTTAGAAACAAATGATGAAAACATAGGGGTTCTGTAAA
CTTTTGTAATGCTATGAATTCTGTTTAAATTTTGGGCTGTCTATTTTCTGCTGAAACCATGCAAAATTGAGCTTTGGTGGGGCTGGGAGG
GGGTTATGTATTCATGGGACCTTTAATTTGTACAGAACACAGAACTTATTTCTGTCAGTTATTTAATACATTGAAAATTTAGTGAAATGT
TCAAAGAGAATAGATGTTTCCCAAAACAACAATCTTTATGTTAAAAATAGTCATTAAAAGATCTGTTGTAATATATGGTGGATATTTTTC
TTTAATTTCAAACATTACCTCTGAAATGTGTATCTTTTCTTTTTTATCTTACCATTAATTTTAAATCTAGTGGATTGGTTTTCAACATCG
TGCCTGCCGATATGCCTACAGAATCATCTGTAAGTGTCAAAATGAACCCACGTTGTTAGCCATAATTTTGATTATGCCTTTATTTCTCCT
TTCTTGAAAAAAAAAAGGTGTTATTTTGACAATTAGGCATAACATTGTTTTGTAGATTATCTTTTAATGAACTATTTTAAATGTTAAATT

>3490_3490_4_AKT3-ADSS_AKT3_chr1_244006427_ENST00000263826_ADSS_chr1_244601070_ENST00000366535_length(amino acids)=351AA_BP=
MFEEAEKNVQKGKGLEGWEKRLIISDRAHIVFDFHQAADGIQEQQRQEQAGKNLGTTKKGIGPVYSSKAARSGLRMCDLVSDFDGFSERF
KVLANQYKSIYPTLEIDIEGELQKLKGYMEKIKPMVRDGVYFLYEALHGPPKKILVEGANAALLDIDFGTYPFVTSSNCTVGGVCTGLGM
PPQNVGEVYGVVKAYTTRVGIGAFPTEQDNEIGELLQTRGREFGVTTGRKRRCGWLDLVLLKYAHMINGFTALALTKLDILDMFTEIKVG

--------------------------------------------------------------
>3490_3490_5_AKT3-ADSS_AKT3_chr1_244006427_ENST00000336199_ADSS_chr1_244601070_ENST00000366535_length(transcript)=2392nt_BP=112nt
CCAAACCCTAAAGCTGATATCACAAAGTACCATTTCTCCAAGTTGGGGGCTCAGAGGGGAGTCATCATGAGCGATGTTACCATTGTGAAA
GAAGGTTGGGTTCAGAAGAGGGGGAGGAAATAATGCTGGCCATACAGTTGTTGTGGATTCTGTGGAATATGATTTTCATCTCTTACCCAG
TGGAATAATTAATCCAAATGTCACTGCATTCATTGGAAATGGTGTGGTAATTCATCTACCTGGATTGTTTGAAGAAGCAGAGAAAAATGT
TCAAAAAGGAAAAGGACTAGAAGGCTGGGAAAAAAGGCTTATTATATCTGACAGAGCTCATATTGTATTTGATTTTCATCAAGCAGCTGA
TGGTATCCAGGAACAACAGAGACAAGAACAAGCAGGAAAAAATTTGGGTACAACAAAAAAGGGCATTGGCCCAGTTTATTCGTCCAAAGC
TGCTCGGAGTGGACTCAGGATGTGCGACCTTGTTTCTGACTTTGATGGCTTCTCTGAGAGGTTTAAAGTTCTAGCTAACCAATACAAATC
TATATACCCCACTTTGGAAATAGACATTGAAGGTGAATTACAAAAACTCAAGGGTTATATGGAAAAGATTAAACCAATGGTGAGAGATGG
AGTTTATTTTCTATATGAGGCCCTACATGGACCACCAAAGAAAATCTTGGTAGAAGGTGCAAATGCAGCACTATTAGATATTGATTTTGG
GACTTACCCTTTTGTAACCTCTTCAAATTGTACTGTTGGAGGTGTTTGTACTGGTTTGGGTATGCCACCTCAAAATGTTGGAGAAGTGTA
TGGAGTTGTGAAAGCTTATACAACTAGAGTTGGTATTGGTGCCTTTCCTACAGAGCAAGACAATGAAATTGGAGAATTATTACAAACAAG
GGGTAGAGAGTTTGGTGTAACTACTGGAAGGAAAAGAAGATGTGGCTGGTTGGACCTCGTTTTGCTCAAATATGCTCATATGATCAATGG
ATTTACTGCGTTGGCACTTACCAAGTTGGATATTTTGGACATGTTTACGGAAATCAAAGTTGGAGTTGCTTACAAGTTAGATGGTGAAAT
CATACCTCATATCCCAGCAAACCAAGAAGTCTTAAATAAAGTTGAAGTTCAATATAAGACTCTCCCAGGATGGAACACAGACATATCAAA
TGCAAGGGCGTTTAAAGAACTACCTGTTAATGCACAAAACTATGTTCGATTTATTGAAGATGAGCTTCAAATTCCAGTTAAGTGGATTGG
TGTTGGTAAATCCAGAGAATCTATGATTCAACTCTTTTAATGATTGCCAGTAATGCAAGAAACACTCCTTGAGAGGGAGGGGAAAAGACT
TTCTTAAATATTTCATTTATGACCTGCAAATTCAAGAATAAAGACACTGAAGTAAGTTTGAAGCCCTACAGTTGTTTCCAGTCTTTTCAG
ATGGATGCCTACTGTGGAGATTAACTTTGGCATATTCCAGTGTCAGCTTTCTTTAGCTGGAATTGCCAAATCATTTGTTGCTCCTGCTGC
TCTCATGGTGCCACGTTTTTTTTTTCAATGTTTAGTAATAGTATAATCCATGTTGTTTGATATCAAAAGTAGAATTACTTTTAATGTAGT
TTTTCTTCATTATTGTCATTGCGTGTTCTTAAGTTTTACCCCTATTAGATGGTAAGAACAATTAATGCAGTTTTGCACAAATATTTTTAC
ATTCTGATCATTCAGTTCTGTCATTGTAATCTTTGTTGTTAGAAACAAATGATGAAAACATAGGGGTTCTGTAAACTTTTGTAATGCTAT
GAATTCTGTTTAAATTTTGGGCTGTCTATTTTCTGCTGAAACCATGCAAAATTGAGCTTTGGTGGGGCTGGGAGGGGGTTATGTATTCAT
GGGACCTTTAATTTGTACAGAACACAGAACTTATTTCTGTCAGTTATTTAATACATTGAAAATTTAGTGAAATGTTCAAAGAGAATAGAT
GTTTCCCAAAACAACAATCTTTATGTTAAAAATAGTCATTAAAAGATCTGTTGTAATATATGGTGGATATTTTTCTTTAATTTCAAACAT
TACCTCTGAAATGTGTATCTTTTCTTTTTTATCTTACCATTAATTTTAAATCTAGTGGATTGGTTTTCAACATCGTGCCTGCCGATATGC
CTACAGAATCATCTGTAAGTGTCAAAATGAACCCACGTTGTTAGCCATAATTTTGATTATGCCTTTATTTCTCCTTTCTTGAAAAAAAAA
AGGTGTTATTTTGACAATTAGGCATAACATTGTTTTGTAGATTATCTTTTAATGAACTATTTTAAATGTTAAATTAGGTGCCACTTAAAT

>3490_3490_5_AKT3-ADSS_AKT3_chr1_244006427_ENST00000336199_ADSS_chr1_244601070_ENST00000366535_length(amino acids)=351AA_BP=
MFEEAEKNVQKGKGLEGWEKRLIISDRAHIVFDFHQAADGIQEQQRQEQAGKNLGTTKKGIGPVYSSKAARSGLRMCDLVSDFDGFSERF
KVLANQYKSIYPTLEIDIEGELQKLKGYMEKIKPMVRDGVYFLYEALHGPPKKILVEGANAALLDIDFGTYPFVTSSNCTVGGVCTGLGM
PPQNVGEVYGVVKAYTTRVGIGAFPTEQDNEIGELLQTRGREFGVTTGRKRRCGWLDLVLLKYAHMINGFTALALTKLDILDMFTEIKVG

--------------------------------------------------------------
>3490_3490_6_AKT3-ADSS_AKT3_chr1_244006427_ENST00000366539_ADSS_chr1_244601070_ENST00000366535_length(transcript)=2527nt_BP=247nt
CCCTCTCCTCCCCCCGCCCCCCCCCGGCTCCATCCTCCGCCGCCGCCCGAGCAGCTGCGGGGCCGCCACCGCCGCCGCCGCCGTTGCAGG
CTGAGTCATCACTAGAGAGTGGGAAGGGCAGCAGCAGCAGAGAATCCAAACCCTAAAGCTGATATCACAAAGTACCATTTCTCCAAGTTG
GGGGCTCAGAGGGGAGTCATCATGAGCGATGTTACCATTGTGAAAGAAGGTTGGGTTCAGAAGAGGGGGAGGAAATAATGCTGGCCATAC
AGTTGTTGTGGATTCTGTGGAATATGATTTTCATCTCTTACCCAGTGGAATAATTAATCCAAATGTCACTGCATTCATTGGAAATGGTGT
GGTAATTCATCTACCTGGATTGTTTGAAGAAGCAGAGAAAAATGTTCAAAAAGGAAAAGGACTAGAAGGCTGGGAAAAAAGGCTTATTAT
ATCTGACAGAGCTCATATTGTATTTGATTTTCATCAAGCAGCTGATGGTATCCAGGAACAACAGAGACAAGAACAAGCAGGAAAAAATTT
GGGTACAACAAAAAAGGGCATTGGCCCAGTTTATTCGTCCAAAGCTGCTCGGAGTGGACTCAGGATGTGCGACCTTGTTTCTGACTTTGA
TGGCTTCTCTGAGAGGTTTAAAGTTCTAGCTAACCAATACAAATCTATATACCCCACTTTGGAAATAGACATTGAAGGTGAATTACAAAA
ACTCAAGGGTTATATGGAAAAGATTAAACCAATGGTGAGAGATGGAGTTTATTTTCTATATGAGGCCCTACATGGACCACCAAAGAAAAT
CTTGGTAGAAGGTGCAAATGCAGCACTATTAGATATTGATTTTGGGACTTACCCTTTTGTAACCTCTTCAAATTGTACTGTTGGAGGTGT
TTGTACTGGTTTGGGTATGCCACCTCAAAATGTTGGAGAAGTGTATGGAGTTGTGAAAGCTTATACAACTAGAGTTGGTATTGGTGCCTT
TCCTACAGAGCAAGACAATGAAATTGGAGAATTATTACAAACAAGGGGTAGAGAGTTTGGTGTAACTACTGGAAGGAAAAGAAGATGTGG
CTGGTTGGACCTCGTTTTGCTCAAATATGCTCATATGATCAATGGATTTACTGCGTTGGCACTTACCAAGTTGGATATTTTGGACATGTT
TACGGAAATCAAAGTTGGAGTTGCTTACAAGTTAGATGGTGAAATCATACCTCATATCCCAGCAAACCAAGAAGTCTTAAATAAAGTTGA
AGTTCAATATAAGACTCTCCCAGGATGGAACACAGACATATCAAATGCAAGGGCGTTTAAAGAACTACCTGTTAATGCACAAAACTATGT
TCGATTTATTGAAGATGAGCTTCAAATTCCAGTTAAGTGGATTGGTGTTGGTAAATCCAGAGAATCTATGATTCAACTCTTTTAATGATT
GCCAGTAATGCAAGAAACACTCCTTGAGAGGGAGGGGAAAAGACTTTCTTAAATATTTCATTTATGACCTGCAAATTCAAGAATAAAGAC
ACTGAAGTAAGTTTGAAGCCCTACAGTTGTTTCCAGTCTTTTCAGATGGATGCCTACTGTGGAGATTAACTTTGGCATATTCCAGTGTCA
GCTTTCTTTAGCTGGAATTGCCAAATCATTTGTTGCTCCTGCTGCTCTCATGGTGCCACGTTTTTTTTTTCAATGTTTAGTAATAGTATA
ATCCATGTTGTTTGATATCAAAAGTAGAATTACTTTTAATGTAGTTTTTCTTCATTATTGTCATTGCGTGTTCTTAAGTTTTACCCCTAT
TAGATGGTAAGAACAATTAATGCAGTTTTGCACAAATATTTTTACATTCTGATCATTCAGTTCTGTCATTGTAATCTTTGTTGTTAGAAA
CAAATGATGAAAACATAGGGGTTCTGTAAACTTTTGTAATGCTATGAATTCTGTTTAAATTTTGGGCTGTCTATTTTCTGCTGAAACCAT
GCAAAATTGAGCTTTGGTGGGGCTGGGAGGGGGTTATGTATTCATGGGACCTTTAATTTGTACAGAACACAGAACTTATTTCTGTCAGTT
ATTTAATACATTGAAAATTTAGTGAAATGTTCAAAGAGAATAGATGTTTCCCAAAACAACAATCTTTATGTTAAAAATAGTCATTAAAAG
ATCTGTTGTAATATATGGTGGATATTTTTCTTTAATTTCAAACATTACCTCTGAAATGTGTATCTTTTCTTTTTTATCTTACCATTAATT
TTAAATCTAGTGGATTGGTTTTCAACATCGTGCCTGCCGATATGCCTACAGAATCATCTGTAAGTGTCAAAATGAACCCACGTTGTTAGC
CATAATTTTGATTATGCCTTTATTTCTCCTTTCTTGAAAAAAAAAAGGTGTTATTTTGACAATTAGGCATAACATTGTTTTGTAGATTAT
CTTTTAATGAACTATTTTAAATGTTAAATTAGGTGCCACTTAAATTTATTTTATTACACCATGAATAGCTGATTAAAAGAACCAAATATT

>3490_3490_6_AKT3-ADSS_AKT3_chr1_244006427_ENST00000366539_ADSS_chr1_244601070_ENST00000366535_length(amino acids)=351AA_BP=
MFEEAEKNVQKGKGLEGWEKRLIISDRAHIVFDFHQAADGIQEQQRQEQAGKNLGTTKKGIGPVYSSKAARSGLRMCDLVSDFDGFSERF
KVLANQYKSIYPTLEIDIEGELQKLKGYMEKIKPMVRDGVYFLYEALHGPPKKILVEGANAALLDIDFGTYPFVTSSNCTVGGVCTGLGM
PPQNVGEVYGVVKAYTTRVGIGAFPTEQDNEIGELLQTRGREFGVTTGRKRRCGWLDLVLLKYAHMINGFTALALTKLDILDMFTEIKVG

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for AKT3-ADSS


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for AKT3-ADSS


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for AKT3-ADSS


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneAKT3C4014738MEGALENCEPHALY-POLYMICROGYRIA-POLYDACTYLY-HYDROCEPHALUS SYNDROME 24GENOMICS_ENGLAND;UNIPROT
HgeneAKT3C4012727MEGALENCEPHALY-POLYMICROGYRIA-POLYDACTYLY-HYDROCEPHALUS SYNDROME 12GENOMICS_ENGLAND
HgeneAKT3C0152427Polydactyly1GENOMICS_ENGLAND
HgeneAKT3C0431380Cortical Dysplasia1CTD_human
HgeneAKT3C0431391Hemimegalencephaly1ORPHANET
HgeneAKT3C1863924Megalanecephaly Polymicrogyria-Polydactyly Hydrocephalus Syndrome1CTD_human;ORPHANET
HgeneAKT3C1955869Malformations of Cortical Development1CTD_human