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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:C1orf132-CD34 (FusionGDB2 ID:HG100128537TG947)

Fusion Gene Summary for C1orf132-CD34

check button Fusion gene summary
Fusion gene informationFusion gene name: C1orf132-CD34
Fusion gene ID: hg100128537tg947
HgeneTgene
Gene symbol

C1orf132

CD34

Gene ID

100128537

947

Gene nameMIR29B2 and MIR29C host geneCD34 molecule
SynonymsC1orf132-
Cytomap('C1orf132')('CD34')

1q32.2

1q32.2

Type of genencRNAprotein-coding
Description-hematopoietic progenitor cell antigen CD34CD34 antigen
Modification date2020031320200313
UniProtAcc.

P28906

Ensembl transtripts involved in fusion geneENST00000385055, ENST00000385231, 
Fusion gene scores* DoF score14 X 8 X 6=6725 X 5 X 4=100
# samples 165
** MAII scorelog2(16/672*10)=-2.0703893278914
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(5/100*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: C1orf132 [Title/Abstract] AND CD34 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointC1orf132(207979350)-CD34(208062966), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneCD34

GO:0001894

tissue homeostasis

12939361

TgeneCD34

GO:0001935

endothelial cell proliferation

21835908

TgeneCD34

GO:0008217

regulation of blood pressure

17505307

TgeneCD34

GO:0030195

negative regulation of blood coagulation

17505307

TgeneCD34

GO:0032720

negative regulation of tumor necrosis factor production

17505307

TgeneCD34

GO:0032733

positive regulation of interleukin-10 production

17505307

TgeneCD34

GO:0038001

paracrine signaling

21835908

TgeneCD34

GO:0042482

positive regulation of odontogenesis

12939361

TgeneCD34

GO:0045019

negative regulation of nitric oxide biosynthetic process

17505307

TgeneCD34

GO:0045766

positive regulation of angiogenesis

12939361|21835908

TgeneCD34

GO:0071636

positive regulation of transforming growth factor beta production

17505307

TgeneCD34

GO:0071657

positive regulation of granulocyte colony-stimulating factor production

9815891

TgeneCD34

GO:0071971

extracellular exosome assembly

21835908

TgeneCD34

GO:0098609

cell-cell adhesion

15249540

TgeneCD34

GO:1900035

negative regulation of cellular response to heat

17505307

TgeneCD34

GO:1900038

negative regulation of cellular response to hypoxia

17505307

TgeneCD34

GO:1900168

positive regulation of glial cell-derived neurotrophic factor secretion

17505307

TgeneCD34

GO:1901215

negative regulation of neuron death

17505307

TgeneCD34

GO:2001214

positive regulation of vasculogenesis

12939361



check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SARCTCGA-IF-A4AK-01AC1orf132chr1

207979350

-CD34chr1

208062966

-


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Fusion Gene ORF analysis for C1orf132-CD34

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-5UTRENST00000385055ENST00000310833C1orf132chr1

207979350

-CD34chr1

208062966

-
intron-5UTRENST00000385055ENST00000356522C1orf132chr1

207979350

-CD34chr1

208062966

-
intron-5UTRENST00000385055ENST00000367036C1orf132chr1

207979350

-CD34chr1

208062966

-
intron-5UTRENST00000385055ENST00000485761C1orf132chr1

207979350

-CD34chr1

208062966

-
intron-5UTRENST00000385055ENST00000537704C1orf132chr1

207979350

-CD34chr1

208062966

-
intron-5UTRENST00000385231ENST00000310833C1orf132chr1

207979350

-CD34chr1

208062966

-
intron-5UTRENST00000385231ENST00000356522C1orf132chr1

207979350

-CD34chr1

208062966

-
intron-5UTRENST00000385231ENST00000367036C1orf132chr1

207979350

-CD34chr1

208062966

-
intron-5UTRENST00000385231ENST00000485761C1orf132chr1

207979350

-CD34chr1

208062966

-
intron-5UTRENST00000385231ENST00000537704C1orf132chr1

207979350

-CD34chr1

208062966

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for C1orf132-CD34


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)


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Fusion Protein Features for C1orf132-CD34


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:207979350/:208062966)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.CD34

P28906

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Possible adhesion molecule with a role in early hematopoiesis by mediating the attachment of stem cells to the bone marrow extracellular matrix or directly to stromal cells. Could act as a scaffold for the attachment of lineage specific glycans, allowing stem cells to bind to lectins expressed by stromal cells or other marrow components. Presents carbohydrate ligands to selectins.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for C1orf132-CD34


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for C1orf132-CD34


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for C1orf132-CD34


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for C1orf132-CD34


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneC0007621Neoplastic Cell Transformation1CTD_human
TgeneC0033975Psychotic Disorders1PSYGENET
TgeneC0041696Unipolar Depression1PSYGENET
TgeneC0349204Nonorganic psychosis1PSYGENET
TgeneC1269683Major Depressive Disorder1PSYGENET
TgeneC2239176Liver carcinoma1CTD_human