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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:GNE-RNF38 (FusionGDB2 ID:HG10020TG152006)

Fusion Gene Summary for GNE-RNF38

Fusion gene summary

Fusion gene information	Fusion gene name: GNE-RNF38
	Fusion gene ID: hg10020tg152006
		Hgene	Tgene
	Gene symbol	GNE	RNF38
	Gene ID	10020	152006
	Gene name	glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase	ring finger protein 38
	Synonyms	DMRV\|GLCNE\|IBM2\|NM\|Uae1	-
	Cytomap	('GNE')('RNF38') 9p13.3	9p13.2
	Type of gene	protein-coding	protein-coding
	Description	bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinaseN-acylmannosamine kinaseUDP-GlcNAc-2-epimerase/ManAc kinaseUDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase	E3 ubiquitin-protein ligase RNF38RING-type E3 ubiquitin transferase RNF38
	Modification date	20200328	20200313
	UniProtAcc	.	.
	Ensembl transtripts involved in fusion gene	ENST00000396594, ENST00000543356, ENST00000377902, ENST00000447283, ENST00000539208, ENST00000539815,
Fusion gene scores	* DoF score	7 X 9 X 6=378	4 X 4 X 5=80
	# samples	10	5
	** MAII score	log2(10/378*10)=-1.91838623444635 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(5/80*10)=-0.678071905112638 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: GNE [Title/Abstract] AND RNF38 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	GNE(36276891)-RNF38(36390613), # samples:1 GNE(36241027)-RNF38(36325703), # samples:1
Anticipated loss of major functional domain due to fusion event.	GNE-RNF38 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. GNE-RNF38 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. GNE-RNF38 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. GNE-RNF38 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	RNF38	GO:0016567	protein ubiquitination	23973461

Fusion gene breakpoints across GNE (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across RNF38 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	STAD	TCGA-HU-A4GH-01A	GNE	chr9	36276891	-	RNF38	chr9	36390613	-

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Fusion Gene ORF analysis for GNE-RNF38

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-5UTR	ENST00000396594	ENST00000357058	GNE	chr9	36276891	-	RNF38	chr9	36390613	-
5CDS-5UTR	ENST00000396594	ENST00000377885	GNE	chr9	36276891	-	RNF38	chr9	36390613	-
5CDS-5UTR	ENST00000396594	ENST00000491349	GNE	chr9	36276891	-	RNF38	chr9	36390613	-
5CDS-5UTR	ENST00000543356	ENST00000357058	GNE	chr9	36276891	-	RNF38	chr9	36390613	-
5CDS-5UTR	ENST00000543356	ENST00000377885	GNE	chr9	36276891	-	RNF38	chr9	36390613	-
5CDS-5UTR	ENST00000543356	ENST00000491349	GNE	chr9	36276891	-	RNF38	chr9	36390613	-
5CDS-intron	ENST00000396594	ENST00000350199	GNE	chr9	36276891	-	RNF38	chr9	36390613	-
5CDS-intron	ENST00000396594	ENST00000353739	GNE	chr9	36276891	-	RNF38	chr9	36390613	-
5CDS-intron	ENST00000396594	ENST00000377877	GNE	chr9	36276891	-	RNF38	chr9	36390613	-
5CDS-intron	ENST00000543356	ENST00000350199	GNE	chr9	36276891	-	RNF38	chr9	36390613	-
5CDS-intron	ENST00000543356	ENST00000353739	GNE	chr9	36276891	-	RNF38	chr9	36390613	-
5CDS-intron	ENST00000543356	ENST00000377877	GNE	chr9	36276891	-	RNF38	chr9	36390613	-
In-frame	ENST00000396594	ENST00000259605	GNE	chr9	36276891	-	RNF38	chr9	36390613	-
In-frame	ENST00000543356	ENST00000259605	GNE	chr9	36276891	-	RNF38	chr9	36390613	-
intron-3CDS	ENST00000377902	ENST00000259605	GNE	chr9	36276891	-	RNF38	chr9	36390613	-
intron-3CDS	ENST00000447283	ENST00000259605	GNE	chr9	36276891	-	RNF38	chr9	36390613	-
intron-3CDS	ENST00000539208	ENST00000259605	GNE	chr9	36276891	-	RNF38	chr9	36390613	-
intron-3CDS	ENST00000539815	ENST00000259605	GNE	chr9	36276891	-	RNF38	chr9	36390613	-
intron-5UTR	ENST00000377902	ENST00000357058	GNE	chr9	36276891	-	RNF38	chr9	36390613	-
intron-5UTR	ENST00000377902	ENST00000377885	GNE	chr9	36276891	-	RNF38	chr9	36390613	-
intron-5UTR	ENST00000377902	ENST00000491349	GNE	chr9	36276891	-	RNF38	chr9	36390613	-
intron-5UTR	ENST00000447283	ENST00000357058	GNE	chr9	36276891	-	RNF38	chr9	36390613	-
intron-5UTR	ENST00000447283	ENST00000377885	GNE	chr9	36276891	-	RNF38	chr9	36390613	-
intron-5UTR	ENST00000447283	ENST00000491349	GNE	chr9	36276891	-	RNF38	chr9	36390613	-
intron-5UTR	ENST00000539208	ENST00000357058	GNE	chr9	36276891	-	RNF38	chr9	36390613	-
intron-5UTR	ENST00000539208	ENST00000377885	GNE	chr9	36276891	-	RNF38	chr9	36390613	-
intron-5UTR	ENST00000539208	ENST00000491349	GNE	chr9	36276891	-	RNF38	chr9	36390613	-
intron-5UTR	ENST00000539815	ENST00000357058	GNE	chr9	36276891	-	RNF38	chr9	36390613	-
intron-5UTR	ENST00000539815	ENST00000377885	GNE	chr9	36276891	-	RNF38	chr9	36390613	-
intron-5UTR	ENST00000539815	ENST00000491349	GNE	chr9	36276891	-	RNF38	chr9	36390613	-
intron-intron	ENST00000377902	ENST00000350199	GNE	chr9	36276891	-	RNF38	chr9	36390613	-
intron-intron	ENST00000377902	ENST00000353739	GNE	chr9	36276891	-	RNF38	chr9	36390613	-
intron-intron	ENST00000377902	ENST00000377877	GNE	chr9	36276891	-	RNF38	chr9	36390613	-
intron-intron	ENST00000447283	ENST00000350199	GNE	chr9	36276891	-	RNF38	chr9	36390613	-
intron-intron	ENST00000447283	ENST00000353739	GNE	chr9	36276891	-	RNF38	chr9	36390613	-
intron-intron	ENST00000447283	ENST00000377877	GNE	chr9	36276891	-	RNF38	chr9	36390613	-
intron-intron	ENST00000539208	ENST00000350199	GNE	chr9	36276891	-	RNF38	chr9	36390613	-
intron-intron	ENST00000539208	ENST00000353739	GNE	chr9	36276891	-	RNF38	chr9	36390613	-
intron-intron	ENST00000539208	ENST00000377877	GNE	chr9	36276891	-	RNF38	chr9	36390613	-
intron-intron	ENST00000539815	ENST00000350199	GNE	chr9	36276891	-	RNF38	chr9	36390613	-
intron-intron	ENST00000539815	ENST00000353739	GNE	chr9	36276891	-	RNF38	chr9	36390613	-
intron-intron	ENST00000539815	ENST00000377877	GNE	chr9	36276891	-	RNF38	chr9	36390613	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000396594	GNE	chr9	36276891	-	ENST00000259605	RNF38	chr9	36390613	-	5055	163	64	1698	544
ENST00000543356	GNE	chr9	36276891	-	ENST00000259605	RNF38	chr9	36390613	-	5041	149	50	1684	544

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000396594	ENST00000259605	GNE	chr9	36276891	-	RNF38	chr9	36390613	-	0.004167922	0.99583215
ENST00000543356	ENST00000259605	GNE	chr9	36276891	-	RNF38	chr9	36390613	-	0.004114731	0.9958853

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Fusion Genomic Features for GNE-RNF38

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

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Fusion Protein Features for GNE-RNF38

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr9:36276891/chr9:36390613)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

RNF38

chr9:36276891

chr9:36390613

ENST00000259605

239_404

516.0

Compositional bias

Note=Pro-rich

Tgene

RNF38

chr9:36276891

chr9:36390613

ENST00000350199

239_404

433.0

Compositional bias

Note=Pro-rich

Tgene

RNF38

chr9:36276891

chr9:36390613

ENST00000353739

239_404

466.0

Compositional bias

Note=Pro-rich

Tgene

RNF38

chr9:36276891

chr9:36390613

ENST00000357058

239_404

433.0

Compositional bias

Note=Pro-rich

Tgene

RNF38

chr9:36276891

chr9:36390613

ENST00000377885

239_404

433.0

Compositional bias

Note=Pro-rich

Tgene

RNF38

chr9:36276891

chr9:36390613

ENST00000259605

115_131

516.0

Motif

Note=Bipartite nuclear localization signal 2

Tgene

RNF38

chr9:36276891

chr9:36390613

ENST00000259605

57_71

516.0

Motif

Note=Bipartite nuclear localization signal 1

Tgene

RNF38

chr9:36276891

chr9:36390613

ENST00000350199

115_131

433.0

Motif

Note=Bipartite nuclear localization signal 2

Tgene

RNF38

chr9:36276891

chr9:36390613

ENST00000350199

57_71

433.0

Motif

Note=Bipartite nuclear localization signal 1

Tgene

RNF38

chr9:36276891

chr9:36390613

ENST00000353739

115_131

466.0

Motif

Note=Bipartite nuclear localization signal 2

Tgene

RNF38

chr9:36276891

chr9:36390613

ENST00000353739

57_71

466.0

Motif

Note=Bipartite nuclear localization signal 1

Tgene

RNF38

chr9:36276891

chr9:36390613

ENST00000357058

115_131

433.0

Motif

Note=Bipartite nuclear localization signal 2

Tgene

RNF38

chr9:36276891

chr9:36390613

ENST00000357058

57_71

433.0

Motif

Note=Bipartite nuclear localization signal 1

Tgene

RNF38

chr9:36276891

chr9:36390613

ENST00000377885

115_131

433.0

Motif

Note=Bipartite nuclear localization signal 2

Tgene

RNF38

chr9:36276891

chr9:36390613

ENST00000377885

57_71

433.0

Motif

Note=Bipartite nuclear localization signal 1

Tgene

RNF38

chr9:36276891

chr9:36390613

ENST00000259605

463_504

516.0

Zinc finger

RING-type

Tgene

RNF38

chr9:36276891

chr9:36390613

ENST00000350199

463_504

433.0

Zinc finger

RING-type

Tgene

RNF38

chr9:36276891

chr9:36390613

ENST00000353739

463_504

466.0

Zinc finger

RING-type

Tgene

RNF38

chr9:36276891

chr9:36390613

ENST00000357058

463_504

433.0

Zinc finger

RING-type

Tgene

RNF38

chr9:36276891

chr9:36390613

ENST00000377885

463_504

433.0

Zinc finger

RING-type

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

GNE

chr9:36276891

chr9:36390613

ENST00000377902

411_420

723.0

Nucleotide binding

Note=ATP

Hgene

GNE

chr9:36276891

chr9:36390613

ENST00000377902

543_552

723.0

Nucleotide binding

Note=ATP

Hgene

GNE

chr9:36276891

chr9:36390613

ENST00000396594

411_420

754.0

Nucleotide binding

Note=ATP

Hgene

GNE

chr9:36276891

chr9:36390613

ENST00000396594

543_552

754.0

Nucleotide binding

Note=ATP

Hgene

GNE

chr9:36276891

chr9:36390613

ENST00000447283

411_420

649.0

Nucleotide binding

Note=ATP

Hgene

GNE

chr9:36276891

chr9:36390613

ENST00000447283

543_552

649.0

Nucleotide binding

Note=ATP

Hgene

GNE

chr9:36276891

chr9:36390613

ENST00000539208

411_420

613.0

Nucleotide binding

Note=ATP

Hgene

GNE

chr9:36276891

chr9:36390613

ENST00000539208

543_552

613.0

Nucleotide binding

Note=ATP

Hgene

GNE

chr9:36276891

chr9:36390613

ENST00000539815

411_420

1065.0

Nucleotide binding

Note=ATP

Hgene

GNE

chr9:36276891

chr9:36390613

ENST00000539815

543_552

1065.0

Nucleotide binding

Note=ATP

Hgene

GNE

chr9:36276891

chr9:36390613

ENST00000377902

406_722

723.0

Region

Note=N-acetylmannosamine kinase

Hgene

GNE

chr9:36276891

chr9:36390613

ENST00000396594

406_722

754.0

Region

Note=N-acetylmannosamine kinase

Hgene

GNE

chr9:36276891

chr9:36390613

ENST00000447283

406_722

649.0

Region

Note=N-acetylmannosamine kinase

Hgene

GNE

chr9:36276891

chr9:36390613

ENST00000539208

406_722

613.0

Region

Note=N-acetylmannosamine kinase

Hgene

GNE

chr9:36276891

chr9:36390613

ENST00000539815

406_722

1065.0

Region

Note=N-acetylmannosamine kinase

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Fusion Gene Sequence for GNE-RNF38

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>33728_33728_1_GNE-RNF38_GNE_chr9_36276891_ENST00000396594_RNF38_chr9_36390613_ENST00000259605_length(transcript)=5055nt_BP=163nt
AGTCTGGAATTCAGATGCCTATTGGTGACTGCTCCGTGGCAGCTAAACCAAGAAAACAGCTGCTCTGCTCATTATTTCAAACCACACTAG
GGTACAGAGCTCGTGCTTCGGGATGGAAACCTATGGTTATCTGCAGAGGGAGTCATGCTTTCAAGGACCTCATATATCTCCCGGGGCCAA
TTCAGCATCTCTACCTGGCCATCCTAACAAGGTGATTTGTGAAAGGGTGAGACTTCAGAGCCTGTTCCCTCTCCTCCCAAGTGATCAGAA
CACTACCGTTCAAGAGGATGCTCACTTCAAAGCTTTCTTCCAGAGTGAAGATAGTCCAAGTCCTAAGAGACAGCGCCTCTCTCATTCAGT
CTTTGATTATACATCAGCATCACCAGCTCCCTCACCACCAATGCGACCATGGGAGATGACATCAAATAGGCAGCCCCCTTCAGTTCGACC
AAGCCAACATCACTTCTCAGGGGAACGATGCAACACACCTGCACGCAACAGAAGAAGTCCTCCTGTCAGGCGCCAGAGAGGAAGAAGGGA
TCGTCTGTCTCGACATAATTCCATTAGTCAAGATGAAAACTATCACCATCTCCCTTACGCACAGCAGCAAGCAATAGAGGAGCCTCGAGC
CTTCCACCCTCCGAATGTATCTCCCCGTCTGCTACATCCTGCTGCTCATCCACCCCAGCAGAATGCAGTCATGGTTGACATACATGATCA
GCTCCATCAAGGAACAGTCCCTGTTTCTTACACAGTAACAACAGTGGCACCACATGGGATTCCACTCTGCACAGGCCAGCACATCCCTGC
TTGTAGTACACAGCAGGTCCCAGGATGCTCTGTGGTTTTCAGTGGACAGCACCTCCCTGTCTGTAGTGTGCCTCCTCCAATGCTTCAGGC
ATGTTCAGTTCAGCACTTACCAGTACCATATGCTGCATTCCCACCCCTTATTTCTAGTGATCCATTTCTTATACATCCTCCTCACCTTTC
TCCCCATCATCCTCCTCATTTGCCACCACCAGGCCAGTTTGTCCCTTTCCAAACACAGCAATCACGATCGCCTCTGCAAAGGATAGAAAA
TGAAGTGGAACTCTTAGGAGAACATCTTCCAGTAGGAGGTTTTACTTACCCTCCATCAGCCCACCCCCCAACATTACCTCCATCAGCTCC
CTTGCAGTTCTTAACACATGATCCTTTGCATCAGGAGGTGTCCTTTGGAGTACCTTATCCTCCATTTATGCCTCGGAGGCTTACAGGACG
TAGTAGATACCGATCCCAGCAGCCAATACCACCTCCCCCTTATCATCCCAGCTTACTGCCATATGTGTTATCAATGCTTCCAGTGCCACC
TGCAGTGGGCCCAACTTTCAGCTTTGAATTAGATGTAGAAGATGGAGAAGTAGAAAATTACGAGGCCCTGTTAAACCTGGCAGAGCGACT
GGGAGAGGCAAAGCCTCGTGGACTGACTAAAGCAGATATTGAACAACTTCCTTCTTATCGGTTCAATCCTAACAACCACCAGTCAGAACA
GACTTTGTGTGTAGTATGCATGTGTGATTTTGAGTCAAGGCAGCTACTTAGAGTCTTACCCTGTAACCACGAGTTCCATGCCAAGTGTGT
TGACAAATGGCTTAAGGCAAATCGTACTTGCCCAATTTGCCGAGCTGATGCTTCAGAAGTGCATCGGGATTCAGAATGACCAACCTAAGA
AGCACAAATTTAGTTTGGGTGTTCCTCATCACATGTATATACGGACTATCCATTGAACTTAATCTGTGTGGCTTCCAGCCCTCCCTTTAC
CAAAAGGGTCAATGGACCTTTCTTTGCACTGTGTGACTTAATCAACTATAAAAGCTTACAATTAGTCTTCACAGTTATGGGATTGTTATA
CTAACCGTGTGATTGGAACTCCAAAGACTTTTTCTTTAGCTTAATTTTGTGTGTGCACTAACATTCCCTGGTTTTTGTGTGATCATTCCG
AGTGTTGCTGCAAGATTACAGTGGACGTGATCTTTTAGCATGTGCTTTTATAAAAAGTGGTAGCTACAGATGATATAGCAATCTACCTTA
TATAGAGCCTTCAGAAACTGTGAGTGGAAATGAATGCGCAGCGTATGACTGTTGGTGATAAGTGTATCTGTGTGAGTGTGTGCAACTACT
TGTGTGAGGGCATGGTAGCTAACGTGTGTATGAGATCCTATATACCAGCATGTACCAAGAATGTGTGTGTAGTTTTAATTATGCTGCAAT
GTATAATCTGGTGTGTTATTTAAACAGCACTAGTACTGTACACTGGTTTTTTTCCCTTGTGTTTGCTGTTGCACACTGATTGCTGAGGGT
GCATCAATTACAAGCATTGAATACTCCATCCCCTTCCCTCCCAGTGAATGGAATGAGAAAAGCCTTCTTCCTTTGCTTCAGGCAGCTGTC
ACCTTCTCTTTATTGGTGGTCCTAAGTGGGTCACTTAAGAAAAAAAAGTGTAACAAATTCTCGCTCCATGAACCTGGTTTTTTTTTATTC
TGTTGTGGAAATTTTTAAATCTCCAACTTGCTGTTTCCAAAAAGAAGGTGCAATATCATATATCATCAGTTAGCAATATTAGCATTTCAA
TCAGTGATTTGAATGTTGATACTTTTTTTTCCTTTACATTTCCAGTAAGTTTCTTACAGAAAGTACCTGTGATTTTTTTTAATGTTTAGA
TTTGTAGTCTAGTCTATTCTGAAGATATTTGATTAATATATTTCTAAGAAGACCACTAGTCCCATGAAGTCTCACCTTGTTGACTTCCAC
CAGAACAAAACCTGTTAATTCAGCTTGACTTCTCATATGTGTTCTGTGTTCAAGCTCCTGTGGGCAACTCAATTGTTTTAAGAAAACTCT
ATTTCTGTTCATATTAATTCACTTGCCAGACTCCAATTCTGAAAGTTGTCTAGTTCTTCCTTCATCACACGTGCTTCTCATCGAAACCCT
GGTTTCAGGATGGATCAAGTGCTGTTACAGCTCATGTTCCTTAGACCTGATTTGTTTTGATATTTTACTGCCTTTCCTTTTAATTTTTGT
TTGAATGAGAAAAGTTTAATACAACAGGTGTCCAGAATACTTGCAGTATAAATGAAGATTTGGTTTTTGTATAAAAAAATAATGCTGTTA
AACAGGAGTTGACCTTCATTTAGTTGATGTAATACATAGCTGTATGGGGTTTTTTTTAGTAAGTTCTTTGAGCATAATTCACTTTAAAGT
CATTTTTCCAGCAATGTTTAAATTACTTTCTCATTCTTTTAGTGTATTCAACATTGTCTGCCTCTTCCTGCAGTTGATGTAATTGCTTTG
TTTGCAATAGCACAAGCTGCATTATTCCAGTCAGGACTGTGATAACTTGCTGCCAGCCCCACTCAACTTTCAGTTGGCTCTGTGTCAGTT
TTCCATTCAGTGTTAACTACTTGTTACTGCCATGCTGCTTGCCCTCCCTTGAAGTGTCTATAAGCTCATCACAGCCTAGAGTTAAGTAAA
GTCAATTCACAGAAGCACAATTTTGCCCTTTGCGAGACATTGTTGCCTCTATCTAGTCCTACAAGTAGGGTTTTGCATACTGTGTTTGCC
CCTAGGGTTGTCAGTGCATCAGAAATACTTCTAAATAGTGGTAAAAATGCACATGGTTAATGCACATGTTACTTTTAAATCATTAGGATA
TCCCTCACCTGTTCCTGATGAATAAAAAGTGTGTTAAAGACCAAAATTCTTGGCATAATAATCAGCTACATACAAATCACATATAGTTTA
ATCTTTTTTAATGAAAAAAAATCATGTTTAAAATGGCAAAAGCCCATCTTATACACTTTTATATAGCTGCAAAAAATTTATATCTGTACA
GATCTAACACTACGACACTCAGTATTCATTTTATTGAAGCATGCAAGTAAAGCACTTTTTCTAATTTATATAGAGGTATCTAATTAACAC
AGCACATTGTACTAATGACTAGGAGTAGCAGCTTTTTCTTCTCTCCCTCTATGAATTCTTATAATGTCCCTTTTTCTGTAAGTTTTTGAG
AGGCAATTGGCAATTTAGGAGGCAGCAGGGTCTGTTTTGGTCAAATCTTGAATTTCGTTGTTGCACTCTAGTGACTGATCTTTGGGAATG
TCTTGTCTTTGCATGGGGCTCATAGAGATGTGTGCAGACTTGCTTATTGTGGTTAGTGTGTATCAGGAACACACACACAGGTGTTCTGAC
CAGCTCAGGCTTGCCACAGTGAGCAACTCTGTGGCTAGCAAAAGAGAAGTTTATTTGTGCCCAGCCATTGGTCACCTTGGGTGATGCACC
AGATAGCAGGCAGATGTTGGTTCATTGGCCTTCGTCCTCTTTCCTCCTAAAATAATATTGGCTTTACCATCTTAACTCAGCTGTGGGTTT
TTTGTGGGTTCTTGTTTGTTTTTTGGCATGAATTGTCATCTTTGGTGTTTTTTTAACCCCCAGCCCCTCAAAAAAATAAGGCCTCCAGGT
ATCAAGATCTCATATTAGGATTTTCTGTCCTTAATTTTTTGAGCAAAATCTGGAAAATGTGAAAGCATATTTAGATTTTATATACTATCT
GAAATGTGATTTGTTAAGATTCTTAAATTTGGGCCTCTTAGAATAATTTTGAATGAGATCTACCGACTCACTTGTGAGAATATTTTTCAC
AGATTATCTTTGGGCCTTTTCATTAGAAAGCTGTTTGTTTGTCCCCCTGTTGGTACATTTGGTTACCTCATTTTGCCGTTTCAGATTGTG
AAAGCTCACAGGGGTGTTTTTTGGAATCATTTGCTGAGTCATTTTCTCAAATCATATTCCATTGTATCAGTTAACATATAGTTTTAAATG
TATGTATTATAAATATCTGTAACCAAATCATTTGAAGGCTTGATAAATTTTTAACAAAGTTTGTACATTTTTTATGAAAGTTACTAGTAA
TGCTTTACTAAGTAGTGCAATGAATTTTTATTTTTAATCCCTGTGCCCAATTTTGGAGTTGAGAGGGTTGTTGGTAATAAATGTATGATG

>33728_33728_1_GNE-RNF38_GNE_chr9_36276891_ENST00000396594_RNF38_chr9_36390613_ENST00000259605_length(amino acids)=544AA_BP=33
MLIISNHTRVQSSCFGMETYGYLQRESCFQGPHISPGANSASLPGHPNKVICERVRLQSLFPLLPSDQNTTVQEDAHFKAFFQSEDSPSP
KRQRLSHSVFDYTSASPAPSPPMRPWEMTSNRQPPSVRPSQHHFSGERCNTPARNRRSPPVRRQRGRRDRLSRHNSISQDENYHHLPYAQ
QQAIEEPRAFHPPNVSPRLLHPAAHPPQQNAVMVDIHDQLHQGTVPVSYTVTTVAPHGIPLCTGQHIPACSTQQVPGCSVVFSGQHLPVC
SVPPPMLQACSVQHLPVPYAAFPPLISSDPFLIHPPHLSPHHPPHLPPPGQFVPFQTQQSRSPLQRIENEVELLGEHLPVGGFTYPPSAH
PPTLPPSAPLQFLTHDPLHQEVSFGVPYPPFMPRRLTGRSRYRSQQPIPPPPYHPSLLPYVLSMLPVPPAVGPTFSFELDVEDGEVENYE
ALLNLAERLGEAKPRGLTKADIEQLPSYRFNPNNHQSEQTLCVVCMCDFESRQLLRVLPCNHEFHAKCVDKWLKANRTCPICRADASEVH

--------------------------------------------------------------
>33728_33728_2_GNE-RNF38_GNE_chr9_36276891_ENST00000543356_RNF38_chr9_36390613_ENST00000259605_length(transcript)=5041nt_BP=149nt
ATGCCTATTGGTGACTGCTCCGTGGCAGCTAAACCAAGAAAACAGCTGCTCTGCTCATTATTTCAAACCACACTAGGGTACAGAGCTCGT
GCTTCGGGATGGAAACCTATGGTTATCTGCAGAGGGAGTCATGCTTTCAAGGACCTCATATATCTCCCGGGGCCAATTCAGCATCTCTAC
CTGGCCATCCTAACAAGGTGATTTGTGAAAGGGTGAGACTTCAGAGCCTGTTCCCTCTCCTCCCAAGTGATCAGAACACTACCGTTCAAG
AGGATGCTCACTTCAAAGCTTTCTTCCAGAGTGAAGATAGTCCAAGTCCTAAGAGACAGCGCCTCTCTCATTCAGTCTTTGATTATACAT
CAGCATCACCAGCTCCCTCACCACCAATGCGACCATGGGAGATGACATCAAATAGGCAGCCCCCTTCAGTTCGACCAAGCCAACATCACT
TCTCAGGGGAACGATGCAACACACCTGCACGCAACAGAAGAAGTCCTCCTGTCAGGCGCCAGAGAGGAAGAAGGGATCGTCTGTCTCGAC
ATAATTCCATTAGTCAAGATGAAAACTATCACCATCTCCCTTACGCACAGCAGCAAGCAATAGAGGAGCCTCGAGCCTTCCACCCTCCGA
ATGTATCTCCCCGTCTGCTACATCCTGCTGCTCATCCACCCCAGCAGAATGCAGTCATGGTTGACATACATGATCAGCTCCATCAAGGAA
CAGTCCCTGTTTCTTACACAGTAACAACAGTGGCACCACATGGGATTCCACTCTGCACAGGCCAGCACATCCCTGCTTGTAGTACACAGC
AGGTCCCAGGATGCTCTGTGGTTTTCAGTGGACAGCACCTCCCTGTCTGTAGTGTGCCTCCTCCAATGCTTCAGGCATGTTCAGTTCAGC
ACTTACCAGTACCATATGCTGCATTCCCACCCCTTATTTCTAGTGATCCATTTCTTATACATCCTCCTCACCTTTCTCCCCATCATCCTC
CTCATTTGCCACCACCAGGCCAGTTTGTCCCTTTCCAAACACAGCAATCACGATCGCCTCTGCAAAGGATAGAAAATGAAGTGGAACTCT
TAGGAGAACATCTTCCAGTAGGAGGTTTTACTTACCCTCCATCAGCCCACCCCCCAACATTACCTCCATCAGCTCCCTTGCAGTTCTTAA
CACATGATCCTTTGCATCAGGAGGTGTCCTTTGGAGTACCTTATCCTCCATTTATGCCTCGGAGGCTTACAGGACGTAGTAGATACCGAT
CCCAGCAGCCAATACCACCTCCCCCTTATCATCCCAGCTTACTGCCATATGTGTTATCAATGCTTCCAGTGCCACCTGCAGTGGGCCCAA
CTTTCAGCTTTGAATTAGATGTAGAAGATGGAGAAGTAGAAAATTACGAGGCCCTGTTAAACCTGGCAGAGCGACTGGGAGAGGCAAAGC
CTCGTGGACTGACTAAAGCAGATATTGAACAACTTCCTTCTTATCGGTTCAATCCTAACAACCACCAGTCAGAACAGACTTTGTGTGTAG
TATGCATGTGTGATTTTGAGTCAAGGCAGCTACTTAGAGTCTTACCCTGTAACCACGAGTTCCATGCCAAGTGTGTTGACAAATGGCTTA
AGGCAAATCGTACTTGCCCAATTTGCCGAGCTGATGCTTCAGAAGTGCATCGGGATTCAGAATGACCAACCTAAGAAGCACAAATTTAGT
TTGGGTGTTCCTCATCACATGTATATACGGACTATCCATTGAACTTAATCTGTGTGGCTTCCAGCCCTCCCTTTACCAAAAGGGTCAATG
GACCTTTCTTTGCACTGTGTGACTTAATCAACTATAAAAGCTTACAATTAGTCTTCACAGTTATGGGATTGTTATACTAACCGTGTGATT
GGAACTCCAAAGACTTTTTCTTTAGCTTAATTTTGTGTGTGCACTAACATTCCCTGGTTTTTGTGTGATCATTCCGAGTGTTGCTGCAAG
ATTACAGTGGACGTGATCTTTTAGCATGTGCTTTTATAAAAAGTGGTAGCTACAGATGATATAGCAATCTACCTTATATAGAGCCTTCAG
AAACTGTGAGTGGAAATGAATGCGCAGCGTATGACTGTTGGTGATAAGTGTATCTGTGTGAGTGTGTGCAACTACTTGTGTGAGGGCATG
GTAGCTAACGTGTGTATGAGATCCTATATACCAGCATGTACCAAGAATGTGTGTGTAGTTTTAATTATGCTGCAATGTATAATCTGGTGT
GTTATTTAAACAGCACTAGTACTGTACACTGGTTTTTTTCCCTTGTGTTTGCTGTTGCACACTGATTGCTGAGGGTGCATCAATTACAAG
CATTGAATACTCCATCCCCTTCCCTCCCAGTGAATGGAATGAGAAAAGCCTTCTTCCTTTGCTTCAGGCAGCTGTCACCTTCTCTTTATT
GGTGGTCCTAAGTGGGTCACTTAAGAAAAAAAAGTGTAACAAATTCTCGCTCCATGAACCTGGTTTTTTTTTATTCTGTTGTGGAAATTT
TTAAATCTCCAACTTGCTGTTTCCAAAAAGAAGGTGCAATATCATATATCATCAGTTAGCAATATTAGCATTTCAATCAGTGATTTGAAT
GTTGATACTTTTTTTTCCTTTACATTTCCAGTAAGTTTCTTACAGAAAGTACCTGTGATTTTTTTTAATGTTTAGATTTGTAGTCTAGTC
TATTCTGAAGATATTTGATTAATATATTTCTAAGAAGACCACTAGTCCCATGAAGTCTCACCTTGTTGACTTCCACCAGAACAAAACCTG
TTAATTCAGCTTGACTTCTCATATGTGTTCTGTGTTCAAGCTCCTGTGGGCAACTCAATTGTTTTAAGAAAACTCTATTTCTGTTCATAT
TAATTCACTTGCCAGACTCCAATTCTGAAAGTTGTCTAGTTCTTCCTTCATCACACGTGCTTCTCATCGAAACCCTGGTTTCAGGATGGA
TCAAGTGCTGTTACAGCTCATGTTCCTTAGACCTGATTTGTTTTGATATTTTACTGCCTTTCCTTTTAATTTTTGTTTGAATGAGAAAAG
TTTAATACAACAGGTGTCCAGAATACTTGCAGTATAAATGAAGATTTGGTTTTTGTATAAAAAAATAATGCTGTTAAACAGGAGTTGACC
TTCATTTAGTTGATGTAATACATAGCTGTATGGGGTTTTTTTTAGTAAGTTCTTTGAGCATAATTCACTTTAAAGTCATTTTTCCAGCAA
TGTTTAAATTACTTTCTCATTCTTTTAGTGTATTCAACATTGTCTGCCTCTTCCTGCAGTTGATGTAATTGCTTTGTTTGCAATAGCACA
AGCTGCATTATTCCAGTCAGGACTGTGATAACTTGCTGCCAGCCCCACTCAACTTTCAGTTGGCTCTGTGTCAGTTTTCCATTCAGTGTT
AACTACTTGTTACTGCCATGCTGCTTGCCCTCCCTTGAAGTGTCTATAAGCTCATCACAGCCTAGAGTTAAGTAAAGTCAATTCACAGAA
GCACAATTTTGCCCTTTGCGAGACATTGTTGCCTCTATCTAGTCCTACAAGTAGGGTTTTGCATACTGTGTTTGCCCCTAGGGTTGTCAG
TGCATCAGAAATACTTCTAAATAGTGGTAAAAATGCACATGGTTAATGCACATGTTACTTTTAAATCATTAGGATATCCCTCACCTGTTC
CTGATGAATAAAAAGTGTGTTAAAGACCAAAATTCTTGGCATAATAATCAGCTACATACAAATCACATATAGTTTAATCTTTTTTAATGA
AAAAAAATCATGTTTAAAATGGCAAAAGCCCATCTTATACACTTTTATATAGCTGCAAAAAATTTATATCTGTACAGATCTAACACTACG
ACACTCAGTATTCATTTTATTGAAGCATGCAAGTAAAGCACTTTTTCTAATTTATATAGAGGTATCTAATTAACACAGCACATTGTACTA
ATGACTAGGAGTAGCAGCTTTTTCTTCTCTCCCTCTATGAATTCTTATAATGTCCCTTTTTCTGTAAGTTTTTGAGAGGCAATTGGCAAT
TTAGGAGGCAGCAGGGTCTGTTTTGGTCAAATCTTGAATTTCGTTGTTGCACTCTAGTGACTGATCTTTGGGAATGTCTTGTCTTTGCAT
GGGGCTCATAGAGATGTGTGCAGACTTGCTTATTGTGGTTAGTGTGTATCAGGAACACACACACAGGTGTTCTGACCAGCTCAGGCTTGC
CACAGTGAGCAACTCTGTGGCTAGCAAAAGAGAAGTTTATTTGTGCCCAGCCATTGGTCACCTTGGGTGATGCACCAGATAGCAGGCAGA
TGTTGGTTCATTGGCCTTCGTCCTCTTTCCTCCTAAAATAATATTGGCTTTACCATCTTAACTCAGCTGTGGGTTTTTTGTGGGTTCTTG
TTTGTTTTTTGGCATGAATTGTCATCTTTGGTGTTTTTTTAACCCCCAGCCCCTCAAAAAAATAAGGCCTCCAGGTATCAAGATCTCATA
TTAGGATTTTCTGTCCTTAATTTTTTGAGCAAAATCTGGAAAATGTGAAAGCATATTTAGATTTTATATACTATCTGAAATGTGATTTGT
TAAGATTCTTAAATTTGGGCCTCTTAGAATAATTTTGAATGAGATCTACCGACTCACTTGTGAGAATATTTTTCACAGATTATCTTTGGG
CCTTTTCATTAGAAAGCTGTTTGTTTGTCCCCCTGTTGGTACATTTGGTTACCTCATTTTGCCGTTTCAGATTGTGAAAGCTCACAGGGG
TGTTTTTTGGAATCATTTGCTGAGTCATTTTCTCAAATCATATTCCATTGTATCAGTTAACATATAGTTTTAAATGTATGTATTATAAAT
ATCTGTAACCAAATCATTTGAAGGCTTGATAAATTTTTAACAAAGTTTGTACATTTTTTATGAAAGTTACTAGTAATGCTTTACTAAGTA
GTGCAATGAATTTTTATTTTTAATCCCTGTGCCCAATTTTGGAGTTGAGAGGGTTGTTGGTAATAAATGTATGATGTACACTTAAAACAT

>33728_33728_2_GNE-RNF38_GNE_chr9_36276891_ENST00000543356_RNF38_chr9_36390613_ENST00000259605_length(amino acids)=544AA_BP=33
MLIISNHTRVQSSCFGMETYGYLQRESCFQGPHISPGANSASLPGHPNKVICERVRLQSLFPLLPSDQNTTVQEDAHFKAFFQSEDSPSP
KRQRLSHSVFDYTSASPAPSPPMRPWEMTSNRQPPSVRPSQHHFSGERCNTPARNRRSPPVRRQRGRRDRLSRHNSISQDENYHHLPYAQ
QQAIEEPRAFHPPNVSPRLLHPAAHPPQQNAVMVDIHDQLHQGTVPVSYTVTTVAPHGIPLCTGQHIPACSTQQVPGCSVVFSGQHLPVC
SVPPPMLQACSVQHLPVPYAAFPPLISSDPFLIHPPHLSPHHPPHLPPPGQFVPFQTQQSRSPLQRIENEVELLGEHLPVGGFTYPPSAH
PPTLPPSAPLQFLTHDPLHQEVSFGVPYPPFMPRRLTGRSRYRSQQPIPPPPYHPSLLPYVLSMLPVPPAVGPTFSFELDVEDGEVENYE
ALLNLAERLGEAKPRGLTKADIEQLPSYRFNPNNHQSEQTLCVVCMCDFESRQLLRVLPCNHEFHAKCVDKWLKANRTCPICRADASEVH

--------------------------------------------------------------

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Fusion Gene PPI Analysis for GNE-RNF38

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for GNE-RNF38

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for GNE-RNF38

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Hgene	GNE	C1853926	NONAKA MYOPATHY	16	CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
Hgene	GNE	C0342853	Sialuria	4	CTD_human;GENOMICS_ENGLAND;UNIPROT
Hgene	GNE	C1833373	Inclusion Body Myopathy, Autosomal Recessive	2	CTD_human;ORPHANET
Hgene	GNE	C0238190	Inclusion Body Myositis (disorder)	1	CTD_human
Hgene	GNE	C0686353	Muscular Dystrophies, Limb-Girdle	1	GENOMICS_ENGLAND
Hgene	GNE	C0751336	Distal Muscular Dystrophies	1	GENOMICS_ENGLAND
Hgene	GNE	C0751713	Inclusion Body Myopathy, Sporadic	1	CTD_human

Fusion Gene Studies in Kim Lab

Fusion gene:GNE-RNF38 (FusionGDB2 ID:HG10020TG152006)

Fusion Gene Summary for GNE-RNF38

Fusion Gene ORF analysis for GNE-RNF38

Fusion Genomic Features for GNE-RNF38

Fusion Protein Features for GNE-RNF38

Fusion Gene Sequence for GNE-RNF38

Fusion Gene PPI Analysis for GNE-RNF38

Related Drugs for GNE-RNF38

Related Diseases for GNE-RNF38

Fusion Gene Studies
in Kim Lab