Fusion Gene Studies
in Kim Lab

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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:GNE-BICC1 (FusionGDB2 ID:HG10020TG80114)

Fusion Gene Summary for GNE-BICC1

check button Fusion gene summary
Fusion gene informationFusion gene name: GNE-BICC1
Fusion gene ID: hg10020tg80114
HgeneTgene
Gene symbol

GNE

BICC1

Gene ID

10020

80114

Gene nameglucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinaseBicC family RNA binding protein 1
SynonymsDMRV|GLCNE|IBM2|NM|Uae1BICC|CYSRD
Cytomap('GNE')('BICC1')

9p13.3

10q21.1

Type of geneprotein-codingprotein-coding
Descriptionbifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinaseN-acylmannosamine kinaseUDP-GlcNAc-2-epimerase/ManAc kinaseUDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinaseprotein bicaudal C homolog 1FGFR2-BICC1 fusion kinase proteinbicaudal C homolog 1
Modification date2020032820200313
UniProtAcc.

Q9H694

Ensembl transtripts involved in fusion geneENST00000377902, ENST00000396594, 
ENST00000447283, ENST00000539208, 
ENST00000539815, ENST00000543356, 
Fusion gene scores* DoF score7 X 9 X 6=3789 X 12 X 6=648
# samples 1013
** MAII scorelog2(10/378*10)=-1.91838623444635
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(13/648*10)=-2.31748218985617
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: GNE [Title/Abstract] AND BICC1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointGNE(36246028)-BICC1(60380615), # samples:2
Anticipated loss of major functional domain due to fusion event.GNE-BICC1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
GNE-BICC1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
GNE-BICC1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
GNE-BICC1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
GNE-BICC1 seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
GNE-BICC1 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneBICC1

GO:0090090

negative regulation of canonical Wnt signaling pathway

21922595


check buttonFusion gene breakpoints across GNE (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across BICC1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SKCMTCGA-BF-AAP1-01AGNEchr9

36246028

-BICC1chr10

60380615

+


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Fusion Gene ORF analysis for GNE-BICC1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000377902ENST00000476684GNEchr9

36246028

-BICC1chr10

60380615

+
5CDS-3UTRENST00000396594ENST00000476684GNEchr9

36246028

-BICC1chr10

60380615

+
5CDS-3UTRENST00000447283ENST00000476684GNEchr9

36246028

-BICC1chr10

60380615

+
5CDS-3UTRENST00000539208ENST00000476684GNEchr9

36246028

-BICC1chr10

60380615

+
5CDS-3UTRENST00000539815ENST00000476684GNEchr9

36246028

-BICC1chr10

60380615

+
5CDS-3UTRENST00000543356ENST00000476684GNEchr9

36246028

-BICC1chr10

60380615

+
5CDS-intronENST00000377902ENST00000263103GNEchr9

36246028

-BICC1chr10

60380615

+
5CDS-intronENST00000396594ENST00000263103GNEchr9

36246028

-BICC1chr10

60380615

+
5CDS-intronENST00000447283ENST00000263103GNEchr9

36246028

-BICC1chr10

60380615

+
5CDS-intronENST00000539208ENST00000263103GNEchr9

36246028

-BICC1chr10

60380615

+
5CDS-intronENST00000539815ENST00000263103GNEchr9

36246028

-BICC1chr10

60380615

+
5CDS-intronENST00000543356ENST00000263103GNEchr9

36246028

-BICC1chr10

60380615

+
Frame-shiftENST00000377902ENST00000373886GNEchr9

36246028

-BICC1chr10

60380615

+
Frame-shiftENST00000447283ENST00000373886GNEchr9

36246028

-BICC1chr10

60380615

+
Frame-shiftENST00000539815ENST00000373886GNEchr9

36246028

-BICC1chr10

60380615

+
In-frameENST00000396594ENST00000373886GNEchr9

36246028

-BICC1chr10

60380615

+
In-frameENST00000539208ENST00000373886GNEchr9

36246028

-BICC1chr10

60380615

+
In-frameENST00000543356ENST00000373886GNEchr9

36246028

-BICC1chr10

60380615

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000396594GNEchr936246028-ENST00000373886BICC1chr1060380615+61008216435551163
ENST00000543356GNEchr936246028-ENST00000373886BICC1chr1060380615+5880601033351111
ENST00000539208GNEchr936246028-ENST00000373886BICC1chr1060380615+585657713833111057

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000396594ENST00000373886GNEchr936246028-BICC1chr1060380615+0.0004699940.9995301
ENST00000543356ENST00000373886GNEchr936246028-BICC1chr1060380615+0.0004432120.9995567
ENST00000539208ENST00000373886GNEchr936246028-BICC1chr1060380615+0.0004432120.9995567

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Fusion Genomic Features for GNE-BICC1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
GNEchr936246027-BICC1chr1060380614+1.52E-050.99998474
GNEchr936246027-BICC1chr1060380614+1.52E-050.99998474

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for GNE-BICC1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr9:36246028/chr10:60380615)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.BICC1

Q9H694

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Putative RNA-binding protein. Acts as a negative regulator of Wnt signaling. May be involved in regulating gene expression during embryonic development. {ECO:0000269|PubMed:21922595}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneBICC1chr9:36246028chr10:60380615ENST00000373886021132_19963975.0DomainKH 1
TgeneBICC1chr9:36246028chr10:60380615ENST00000373886021284_34863975.0DomainKH 2
TgeneBICC1chr9:36246028chr10:60380615ENST00000373886021873_93663975.0DomainSAM

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneGNEchr9:36246028chr10:60380615ENST00000377902-312411_420205723.0Nucleotide bindingNote=ATP
HgeneGNEchr9:36246028chr10:60380615ENST00000377902-312543_552205723.0Nucleotide bindingNote=ATP
HgeneGNEchr9:36246028chr10:60380615ENST00000396594-312411_420236754.0Nucleotide bindingNote=ATP
HgeneGNEchr9:36246028chr10:60380615ENST00000396594-312543_552236754.0Nucleotide bindingNote=ATP
HgeneGNEchr9:36246028chr10:60380615ENST00000447283-311411_420205649.0Nucleotide bindingNote=ATP
HgeneGNEchr9:36246028chr10:60380615ENST00000447283-311543_552205649.0Nucleotide bindingNote=ATP
HgeneGNEchr9:36246028chr10:60380615ENST00000539208-210411_420146613.0Nucleotide bindingNote=ATP
HgeneGNEchr9:36246028chr10:60380615ENST00000539208-210543_552146613.0Nucleotide bindingNote=ATP
HgeneGNEchr9:36246028chr10:60380615ENST00000539815-212411_4202051065.0Nucleotide bindingNote=ATP
HgeneGNEchr9:36246028chr10:60380615ENST00000539815-212543_5522051065.0Nucleotide bindingNote=ATP
HgeneGNEchr9:36246028chr10:60380615ENST00000377902-312406_722205723.0RegionNote=N-acetylmannosamine kinase
HgeneGNEchr9:36246028chr10:60380615ENST00000396594-312406_722236754.0RegionNote=N-acetylmannosamine kinase
HgeneGNEchr9:36246028chr10:60380615ENST00000447283-311406_722205649.0RegionNote=N-acetylmannosamine kinase
HgeneGNEchr9:36246028chr10:60380615ENST00000539208-210406_722146613.0RegionNote=N-acetylmannosamine kinase
HgeneGNEchr9:36246028chr10:60380615ENST00000539815-212406_7222051065.0RegionNote=N-acetylmannosamine kinase


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Fusion Gene Sequence for GNE-BICC1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>33723_33723_1_GNE-BICC1_GNE_chr9_36246028_ENST00000396594_BICC1_chr10_60380615_ENST00000373886_length(transcript)=6100nt_BP=821nt
AGTCTGGAATTCAGATGCCTATTGGTGACTGCTCCGTGGCAGCTAAACCAAGAAAACAGCTGCTCTGCTCATTATTTCAAACCACACTAG
GGTACAGAGCTCGTGCTTCGGGATGGAAACCTATGGTTATCTGCAGAGGGAGTCATGCTTTCAAGGACCTCATGAACTCTATTTTAAGAA
CCTCTCAAAACGAAACAAGCAAATCATGGAGAAGAATGGAAATAACCGAAAGCTGCGGGTTTGTGTTGCTACTTGTAACCGTGCAGATTA
TTCTAAACTTGCCCCGATCATGTTTGGCATTAAAACCGAACCTGAGTTCTTTGAACTTGATGTTGTGGTACTTGGCTCTCACCTGATAGA
TGACTATGGAAATACATATCGAATGATTGAACAAGATGACTTTGACATTAACACCAGGCTACACACAATTGTGAGGGGAGAAGATGAGGC
AGCCATGGTGGAGTCAGTAGGCCTGGCCCTAGTGAAGCTGCCAGATGTCCTTAATCGCCTGAAGCCTGATATCATGATTGTTCATGGAGA
CAGGTTTGATGCCCTGGCTCTGGCCACATCTGCTGCCTTGATGAACATCCGAATCCTTCACATTGAAGGTGGGGAAGTCAGTGGGACCAT
TGATGACTCTATCAGACATGCCATAACAAAACTGGCTCATTATCATGTGTGCTGCACCCGCAGTGCAGAGCAGCACCTGATATCCATGTG
TGAGGACCATGATCGCATCCTTTTGGCAGGCTGCCCTTCCTATGACAAACTTCTCTCAGCCAAGAACAAAGACTACATGAGCATCATTCG
CATGTGGCTAGCTGCTGCTGAAGGGAAAGGCAGAAGTGGGGAAGACTTTTTTCAAAAGATCATGGAGGAAACAAATACGCAGATTGCTTG
GCCATCAAAACTGAAGATCGGAGCCAAATCCAAGAAAGATCCCCATATTAAGGTTTCTGGAAAGAAAGAAGATGTTAAAGAAGCCAAGGA
AATGATCATGTCTGTCTTAGACACAAAAAGCAATCGAGTCACACTGAAGATGGATGTTTCACATACAGAACATTCACATGTAATCGGCAA
AGGTGGCAACAATATTAAAAAAGTGATGGAAGAAACCGGATGCCATATCCACTTTCCAGATTCCAACAGGAATAACCAAGCAGAAAAAAG
CAACCAGGTATCTATAGCGGGACAACCAGCAGGAGTAGAATCTGCCCGAGTTAGAATTCGGGAGCTGCTTCCTTTGGTGCTGATGTTTGA
GCTACCAATTGCTGGAATTCTTCAACCGGTTCCTGATCCTAATTCCCCCTCTATTCAGCATATATCACAAACGTACAATATTTCAGTATC
ATTTAAACAGCGTTCCCGAATGTATGGTGCTACTGTCATAGTACGAGGGTCTCAGAATAACACTAGTGCTGTGAAGGAAGGAACTGCCAT
GCTGTTAGAACATCTTGCTGGGAGCTTAGCATCAGCTATTCCTGTGAGCACACAACTAGATATTGCAGCTCAACATCATCTCTTTATGAT
GGGTCGAAATGGGAGCAACATCAAACATATCATGCAGAGAACAGGTGCTCAGATCCACTTTCCTGATCCCAGTAATCCACAAAAGAAATC
TACCGTCTACCTCCAGGGCACCATTGAGTCTGTCTGTCTTGCAAGGCAATATCTCATGGGTTGTCTTCCTCTTGTGTTGATGTTTGATAT
GAAGGAAGAAATTGAAGTAGATCCACAATTCATTGCGCAGTTGATGGAACAGCTTGATGTCTTCATCAGTATTAAACCAAAGCCCAAACA
GCCAAGCAAGTCTGTGATTGTGAAAAGTGTTGAGCGAAATGCCTTAAATATGTATGAAGCAAGGAAATGTCTCCTCGGACTTGAAAGCAG
TGGGGTTACCATAGCAACCAGTCCATCCCCAGCATCCTGCCCTGCCGGCCTGGCATGTCCCAGCCTGGATATCTTAGCTTCAGCAGGCCT
TGGACTCACTGGACTAGGTCTTTTGGGACCCACCACCTTATCTCTGAACACTTCAACAACCCCAAACTCACTCTTGAATGCTCTTAATAG
CTCAGTCAGTCCTTTGCAAAGTCCAAGTTCTGGTACACCCAGCCCCACATTATGGGCACCCCCACTTGCTAATACTTCAAGTGCCACAGG
TTTTTCTGCTATACCACACCTTATGATTCCATCTACTGCCCAAGCCACATTAACTAATATTTTGTTGTCTGGAGTGCCCACCTATGGGCA
CACAGCTCCATCTCCCCCTCCTGGCTTGACTCCTGTTGATGTCCATATCAACAGTATGCAGACCGAAGGCAAAAAAATCTCTGCTGCTTT
AAATGGACATGCACAGTCTCCAGATATAAAATATGGTGCAATATCCACTTCATCACTTGGAGAAAAAGTGCTGAGTGCAAATCACGGGGA
TCCGTCCATCCAGACAAGTGGGTCTGAGCAGACATCTCCCAAATCAAGCCCCACTGAAGGTTGTAATGATGCTTTTGTTGAAGTAGGCAT
GCCTCGAAGTCCTTCCCATTCTGGGAATGCTGGTGACTTGAAACAGATGATGTGTCCCTCCAAGGTTTCCTGTGCCAAAAGGCAGACAGT
GGAACTATTGCAAGGCACGAAAAACTCACACTTACACAGCACTGACAGGTTGCTCTCAGACCCTGAACTGAGTGCTACCGAAAGCCCTTT
GGCTGACAAGAAGGCTCCAGGGAGTGAGCGCGCTGCAGAGAGGGCAGCAGCTGCCCAGCAAAACTCCGAAAGGGCCCACCTTGCTCCACG
GTCATCATATGTCAACATGCAGGCATTTGACTATGAACAGAAGAAGCTATTAGCCACCAAAGCTATGTTAAAGAAACCAGTGGTGACGGA
GGTCAGAACGCCCACAAATACCTGGAGTGGCCTGGGTTTTTCTAAATCCATGCCAGCTGAAACTATCAAGGAGTTGAGAAGGGCCAATCA
TGTGTCCTATAAGCCCACAATGACAACCACTTATGAGGGCTCATCCATGTCCCTTTCACGGTCCAACAGTCGTGAGCACTTGGGAGGTGG
AAGCGAATCTGATAACTGGAGAGACCGAAATGGAATTGGACCTGGAAGTCATAGTGAATTTGCAGCTTCTATTGGCAGCCCTAAGCGTAA
ACAAAACAAATCAACGGAACACTATCTCAGCAGTAGCAATTACATGGACTGCATTTCCTCGCTGACAGGAAGCAATGGCTGTAACTTAAA
TAGCTCTTTCAAAGGTTCTGACCTCCCTGAGCTCTTCAGCAAACTGGGCCTGGGCAAATACACAGATGTTTTCCAGCAACAAGAGATCGA
TCTTCAGACATTCCTCACTCTCACAGATCAGGATCTGAAGGAGCTGGGAATAACTACTTTTGGTGCCAGGAGGAAAATGCTGCTTGCAAT
TTCAGAACTAAATAAAAACCGAAGAAAGCTTTTTGAATCGCCAAATGCACGCACCTCTTTCCTGGAAGGTGGAGCGAGTGGAAGGCTACC
CCGTCAGTATCACTCAGACATTGCTAGTGTCAGTGGCCGCTGGTAGCAGCACCCTCTTGGCACATGCCCGCTGACTAACTGTAAAGTGGA
CACAGGAGATGTATGAACAGCCTTCACAGCACACCATCCTTAGCACTCTGGGTGTCTGGTATCAGGACCAAAGCATTTTATTCGCACCTG
TACTTTATGGCAAAAAGGAAGAAGAGAGAGAAGATGTTCTTATGATGTCATACAGAACACCAAATATGGATTACTTTTTTAAAATGGCAG
TTGGACAGAATTTGCAATATAAGGATAGGGCTTTATTTCCTGTTTTTATTTACCTATATAACATATGCACTGATGATTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTACTTAAAATGAAGGATGAATTGACATCTGGGATGCCAGAAGACTTAGAAGTTATTTTGTTTGCTTGTTTTGTT
TGGGTATTTGGGGATTTTTAAAAAATAATCAAAGTGGAATTTTCTGGTACTGCTTTAAAATAATTATTGTGGTCTTTCAGCACTTTACAC
GTTCTAATTTCTTGTCCTATGGAAGTTCTCGCTGTCTCCATCTCTCTCATTTTTGTGTCACCTAATATGTTGGTACAGATAAGAGTTAGT
CACATTTTTCTGACTGCATCAAACTTTTATTTGAAATGGTACTGGATCTTAGTTTCTGTGCAGAATATTCTGTGATTTTGGGAAATGTAA
GTGAGTCCACTTGCTTCTGGACCAATTCTGTTTCATGTATGTTAGCATCCTAGAAACACCTAGCAATGGACCTAGTTCACAGTAATAGGT
GCAAAGAAAGACCAAATGGACTTTGCAGTATTAACCCTTTGCAGTCGTCATACTTAGCTGCTGCCTGTAATGCTAAAATGATTTTAATGG
TTGTCTGGAGGCAAAGGGCTGTTTTTTAGTATATTGCCACTAAAGGACATTTATTTATATCAAACTTTTATTTTTAGATATTATAAGCAT
ACAGTACATAATTGATGAAATTGATATTTACTAGAGATTTATGGTAGAGAATGGACGACATTCAATAACTGGAGCCCGAGATTGTCACTT
TATTTAAAAAGACAAATAATCATCTGACAAGACAGCACTGTTGCCATTATAAGGAGAAATAGATTACAATCCTTATCATGTACACGTTAG
CTATGTTCCGTATGGCCACAGGACTTTCCTGAAACCGTATCTGTCTGCTTGAAGTAGACTTATGTTTGTTGAGAATGAACAGGCTTATTT
GAGCCTCCAGGGTGGCAGTTCATAAAGACAGCTAAGTTCTGAAGGAAAAAAAAAATATATCTTTTTAAGTGGCTAGAGTCATTATTACAA
TCTTATACTGTGAAAGTCCAAGAAATCAGGCAACATTGTTTCCTGGGTCTTTTCAGAGATCTTATAGATTTATGAAGTGTTTTTAATCCA
TGAAGAAACACTAAAGTGCCTTTCTTTCTTCAAAGCAATATTATTTCCAAGTATATTAATTTGTTAGAAAACTTTCCCATAGGAAATGTT
GTCAAGTTACCTGTACTGTAAAGAGTTATTTATGTTCAGTAGTCAAGATTTTCTACATGGACATAAACCACTCTCACGTGCTCTCAGCAG
AAGGCATTAGATAAGCATATACAAGAATTGGGTACTTTTATACAAATATGGGATAAGAAATACTTGCCTGACACTTTTCCATGGCTGAGT
CTGACCATTACAGTAAGAACAAGAATTGAAGAGGCATTTTGCACACAGAAACATTCTCACTTTAAAAAATGGTATTGGTTACCTTGAAGG
CATAGATAATGGGCCTGTCATAAAATTATCAATTATAACTGGCACCGAGGGACTGCCCTTTTTAAGCTAAACTAAGCCTTATCTGCTTAA
GGATGTTGAACTGAATCACTCCCTTTACTCATCCTGTGCATATGTGTACAAATGGTCATGTGGATCATGTGATGATCATCCATCTTATTT
GATTGTATTAATGCATCATGCTAAACATGTAGTACAGGTTAACAATACCAGATTTATGTCCTGTTCAACAACTCAGTACTCTAAATGTTG
TTATGCTTTTAATAAGACCTTCCCAGATAATAATCTTGGAGCTCTTTTCCCAGCTGTCTACCATGCATTTGCAACAGGAGGAAGATGTAA
TGAATATGCAGTATTAAGTTGATTTATGAACAGTGCTTTGATATGCCAAAGGGAAAACTGTCCCACTTAAATTAGATTAAGTAGGGTGGC
TAAAAATAAATAAAAACACTGGAAATTCTTTCTCTCACTTTCTCTTGATGCAATGAAGGGAATATGACACTACAGTATACAGAGTTGTTG
TTATATGATGCACAAAATATTTTGATGATTTGAATAAATGTTAACTTTTAATCTGCGCCTTAATAATGACTGGTTATCTGTAAATATAGA
ACAGATACAGATTGTATTTTTCTGTGGGTTTTTGTCCTTTTAGTGATTTTTTTCCAAAAACGAGAGATGGAATTAACATTGAAAATGGGA
AATTTTTCTAACTGAATCAATTGTTACATGAAAAATAAATTTATATAACCCCTTTGTATTGCTCTTGCTA

>33723_33723_1_GNE-BICC1_GNE_chr9_36246028_ENST00000396594_BICC1_chr10_60380615_ENST00000373886_length(amino acids)=1163AA_BP=252
MLIISNHTRVQSSCFGMETYGYLQRESCFQGPHELYFKNLSKRNKQIMEKNGNNRKLRVCVATCNRADYSKLAPIMFGIKTEPEFFELDV
VVLGSHLIDDYGNTYRMIEQDDFDINTRLHTIVRGEDEAAMVESVGLALVKLPDVLNRLKPDIMIVHGDRFDALALATSAALMNIRILHI
EGGEVSGTIDDSIRHAITKLAHYHVCCTRSAEQHLISMCEDHDRILLAGCPSYDKLLSAKNKDYMSIIRMWLAAAEGKGRSGEDFFQKIM
EETNTQIAWPSKLKIGAKSKKDPHIKVSGKKEDVKEAKEMIMSVLDTKSNRVTLKMDVSHTEHSHVIGKGGNNIKKVMEETGCHIHFPDS
NRNNQAEKSNQVSIAGQPAGVESARVRIRELLPLVLMFELPIAGILQPVPDPNSPSIQHISQTYNISVSFKQRSRMYGATVIVRGSQNNT
SAVKEGTAMLLEHLAGSLASAIPVSTQLDIAAQHHLFMMGRNGSNIKHIMQRTGAQIHFPDPSNPQKKSTVYLQGTIESVCLARQYLMGC
LPLVLMFDMKEEIEVDPQFIAQLMEQLDVFISIKPKPKQPSKSVIVKSVERNALNMYEARKCLLGLESSGVTIATSPSPASCPAGLACPS
LDILASAGLGLTGLGLLGPTTLSLNTSTTPNSLLNALNSSVSPLQSPSSGTPSPTLWAPPLANTSSATGFSAIPHLMIPSTAQATLTNIL
LSGVPTYGHTAPSPPPGLTPVDVHINSMQTEGKKISAALNGHAQSPDIKYGAISTSSLGEKVLSANHGDPSIQTSGSEQTSPKSSPTEGC
NDAFVEVGMPRSPSHSGNAGDLKQMMCPSKVSCAKRQTVELLQGTKNSHLHSTDRLLSDPELSATESPLADKKAPGSERAAERAAAAQQN
SERAHLAPRSSYVNMQAFDYEQKKLLATKAMLKKPVVTEVRTPTNTWSGLGFSKSMPAETIKELRRANHVSYKPTMTTTYEGSSMSLSRS
NSREHLGGGSESDNWRDRNGIGPGSHSEFAASIGSPKRKQNKSTEHYLSSSNYMDCISSLTGSNGCNLNSSFKGSDLPELFSKLGLGKYT
DVFQQQEIDLQTFLTLTDQDLKELGITTFGARRKMLLAISELNKNRRKLFESPNARTSFLEGGASGRLPRQYHSDIASVSGRW

--------------------------------------------------------------
>33723_33723_2_GNE-BICC1_GNE_chr9_36246028_ENST00000539208_BICC1_chr10_60380615_ENST00000373886_length(transcript)=5856nt_BP=577nt
TACCCGCGCGCCCGAGCGCGGAAACCGAGGGGCAGGCTCGCGCTCTGCCTGCTTCGTGGCGCTTGGTTCGTCCCTCGCCCGAGGAGCGCG
GTGGCGGCGTGGGAGGGAGCCTCTGACGGCGTCTGAAATACATATCGAATGATTGAACAAGATGACTTTGACATTAACACCAGGCTACAC
ACAATTGTGAGGGGAGAAGATGAGGCAGCCATGGTGGAGTCAGTAGGCCTGGCCCTAGTGAAGCTGCCAGATGTCCTTAATCGCCTGAAG
CCTGATATCATGATTGTTCATGGAGACAGGTTTGATGCCCTGGCTCTGGCCACATCTGCTGCCTTGATGAACATCCGAATCCTTCACATT
GAAGGTGGGGAAGTCAGTGGGACCATTGATGACTCTATCAGACATGCCATAACAAAACTGGCTCATTATCATGTGTGCTGCACCCGCAGT
GCAGAGCAGCACCTGATATCCATGTGTGAGGACCATGATCGCATCCTTTTGGCAGGCTGCCCTTCCTATGACAAACTTCTCTCAGCCAAG
AACAAAGACTACATGAGCATCATTCGCATGTGGCTAGCTGCTGCTGAAGGGAAAGGCAGAAGTGGGGAAGACTTTTTTCAAAAGATCATG
GAGGAAACAAATACGCAGATTGCTTGGCCATCAAAACTGAAGATCGGAGCCAAATCCAAGAAAGATCCCCATATTAAGGTTTCTGGAAAG
AAAGAAGATGTTAAAGAAGCCAAGGAAATGATCATGTCTGTCTTAGACACAAAAAGCAATCGAGTCACACTGAAGATGGATGTTTCACAT
ACAGAACATTCACATGTAATCGGCAAAGGTGGCAACAATATTAAAAAAGTGATGGAAGAAACCGGATGCCATATCCACTTTCCAGATTCC
AACAGGAATAACCAAGCAGAAAAAAGCAACCAGGTATCTATAGCGGGACAACCAGCAGGAGTAGAATCTGCCCGAGTTAGAATTCGGGAG
CTGCTTCCTTTGGTGCTGATGTTTGAGCTACCAATTGCTGGAATTCTTCAACCGGTTCCTGATCCTAATTCCCCCTCTATTCAGCATATA
TCACAAACGTACAATATTTCAGTATCATTTAAACAGCGTTCCCGAATGTATGGTGCTACTGTCATAGTACGAGGGTCTCAGAATAACACT
AGTGCTGTGAAGGAAGGAACTGCCATGCTGTTAGAACATCTTGCTGGGAGCTTAGCATCAGCTATTCCTGTGAGCACACAACTAGATATT
GCAGCTCAACATCATCTCTTTATGATGGGTCGAAATGGGAGCAACATCAAACATATCATGCAGAGAACAGGTGCTCAGATCCACTTTCCT
GATCCCAGTAATCCACAAAAGAAATCTACCGTCTACCTCCAGGGCACCATTGAGTCTGTCTGTCTTGCAAGGCAATATCTCATGGGTTGT
CTTCCTCTTGTGTTGATGTTTGATATGAAGGAAGAAATTGAAGTAGATCCACAATTCATTGCGCAGTTGATGGAACAGCTTGATGTCTTC
ATCAGTATTAAACCAAAGCCCAAACAGCCAAGCAAGTCTGTGATTGTGAAAAGTGTTGAGCGAAATGCCTTAAATATGTATGAAGCAAGG
AAATGTCTCCTCGGACTTGAAAGCAGTGGGGTTACCATAGCAACCAGTCCATCCCCAGCATCCTGCCCTGCCGGCCTGGCATGTCCCAGC
CTGGATATCTTAGCTTCAGCAGGCCTTGGACTCACTGGACTAGGTCTTTTGGGACCCACCACCTTATCTCTGAACACTTCAACAACCCCA
AACTCACTCTTGAATGCTCTTAATAGCTCAGTCAGTCCTTTGCAAAGTCCAAGTTCTGGTACACCCAGCCCCACATTATGGGCACCCCCA
CTTGCTAATACTTCAAGTGCCACAGGTTTTTCTGCTATACCACACCTTATGATTCCATCTACTGCCCAAGCCACATTAACTAATATTTTG
TTGTCTGGAGTGCCCACCTATGGGCACACAGCTCCATCTCCCCCTCCTGGCTTGACTCCTGTTGATGTCCATATCAACAGTATGCAGACC
GAAGGCAAAAAAATCTCTGCTGCTTTAAATGGACATGCACAGTCTCCAGATATAAAATATGGTGCAATATCCACTTCATCACTTGGAGAA
AAAGTGCTGAGTGCAAATCACGGGGATCCGTCCATCCAGACAAGTGGGTCTGAGCAGACATCTCCCAAATCAAGCCCCACTGAAGGTTGT
AATGATGCTTTTGTTGAAGTAGGCATGCCTCGAAGTCCTTCCCATTCTGGGAATGCTGGTGACTTGAAACAGATGATGTGTCCCTCCAAG
GTTTCCTGTGCCAAAAGGCAGACAGTGGAACTATTGCAAGGCACGAAAAACTCACACTTACACAGCACTGACAGGTTGCTCTCAGACCCT
GAACTGAGTGCTACCGAAAGCCCTTTGGCTGACAAGAAGGCTCCAGGGAGTGAGCGCGCTGCAGAGAGGGCAGCAGCTGCCCAGCAAAAC
TCCGAAAGGGCCCACCTTGCTCCACGGTCATCATATGTCAACATGCAGGCATTTGACTATGAACAGAAGAAGCTATTAGCCACCAAAGCT
ATGTTAAAGAAACCAGTGGTGACGGAGGTCAGAACGCCCACAAATACCTGGAGTGGCCTGGGTTTTTCTAAATCCATGCCAGCTGAAACT
ATCAAGGAGTTGAGAAGGGCCAATCATGTGTCCTATAAGCCCACAATGACAACCACTTATGAGGGCTCATCCATGTCCCTTTCACGGTCC
AACAGTCGTGAGCACTTGGGAGGTGGAAGCGAATCTGATAACTGGAGAGACCGAAATGGAATTGGACCTGGAAGTCATAGTGAATTTGCA
GCTTCTATTGGCAGCCCTAAGCGTAAACAAAACAAATCAACGGAACACTATCTCAGCAGTAGCAATTACATGGACTGCATTTCCTCGCTG
ACAGGAAGCAATGGCTGTAACTTAAATAGCTCTTTCAAAGGTTCTGACCTCCCTGAGCTCTTCAGCAAACTGGGCCTGGGCAAATACACA
GATGTTTTCCAGCAACAAGAGATCGATCTTCAGACATTCCTCACTCTCACAGATCAGGATCTGAAGGAGCTGGGAATAACTACTTTTGGT
GCCAGGAGGAAAATGCTGCTTGCAATTTCAGAACTAAATAAAAACCGAAGAAAGCTTTTTGAATCGCCAAATGCACGCACCTCTTTCCTG
GAAGGTGGAGCGAGTGGAAGGCTACCCCGTCAGTATCACTCAGACATTGCTAGTGTCAGTGGCCGCTGGTAGCAGCACCCTCTTGGCACA
TGCCCGCTGACTAACTGTAAAGTGGACACAGGAGATGTATGAACAGCCTTCACAGCACACCATCCTTAGCACTCTGGGTGTCTGGTATCA
GGACCAAAGCATTTTATTCGCACCTGTACTTTATGGCAAAAAGGAAGAAGAGAGAGAAGATGTTCTTATGATGTCATACAGAACACCAAA
TATGGATTACTTTTTTAAAATGGCAGTTGGACAGAATTTGCAATATAAGGATAGGGCTTTATTTCCTGTTTTTATTTACCTATATAACAT
ATGCACTGATGATTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTACTTAAAATGAAGGATGAATTGACATCTGGGATGCCAGAAGACTTAG
AAGTTATTTTGTTTGCTTGTTTTGTTTGGGTATTTGGGGATTTTTAAAAAATAATCAAAGTGGAATTTTCTGGTACTGCTTTAAAATAAT
TATTGTGGTCTTTCAGCACTTTACACGTTCTAATTTCTTGTCCTATGGAAGTTCTCGCTGTCTCCATCTCTCTCATTTTTGTGTCACCTA
ATATGTTGGTACAGATAAGAGTTAGTCACATTTTTCTGACTGCATCAAACTTTTATTTGAAATGGTACTGGATCTTAGTTTCTGTGCAGA
ATATTCTGTGATTTTGGGAAATGTAAGTGAGTCCACTTGCTTCTGGACCAATTCTGTTTCATGTATGTTAGCATCCTAGAAACACCTAGC
AATGGACCTAGTTCACAGTAATAGGTGCAAAGAAAGACCAAATGGACTTTGCAGTATTAACCCTTTGCAGTCGTCATACTTAGCTGCTGC
CTGTAATGCTAAAATGATTTTAATGGTTGTCTGGAGGCAAAGGGCTGTTTTTTAGTATATTGCCACTAAAGGACATTTATTTATATCAAA
CTTTTATTTTTAGATATTATAAGCATACAGTACATAATTGATGAAATTGATATTTACTAGAGATTTATGGTAGAGAATGGACGACATTCA
ATAACTGGAGCCCGAGATTGTCACTTTATTTAAAAAGACAAATAATCATCTGACAAGACAGCACTGTTGCCATTATAAGGAGAAATAGAT
TACAATCCTTATCATGTACACGTTAGCTATGTTCCGTATGGCCACAGGACTTTCCTGAAACCGTATCTGTCTGCTTGAAGTAGACTTATG
TTTGTTGAGAATGAACAGGCTTATTTGAGCCTCCAGGGTGGCAGTTCATAAAGACAGCTAAGTTCTGAAGGAAAAAAAAAATATATCTTT
TTAAGTGGCTAGAGTCATTATTACAATCTTATACTGTGAAAGTCCAAGAAATCAGGCAACATTGTTTCCTGGGTCTTTTCAGAGATCTTA
TAGATTTATGAAGTGTTTTTAATCCATGAAGAAACACTAAAGTGCCTTTCTTTCTTCAAAGCAATATTATTTCCAAGTATATTAATTTGT
TAGAAAACTTTCCCATAGGAAATGTTGTCAAGTTACCTGTACTGTAAAGAGTTATTTATGTTCAGTAGTCAAGATTTTCTACATGGACAT
AAACCACTCTCACGTGCTCTCAGCAGAAGGCATTAGATAAGCATATACAAGAATTGGGTACTTTTATACAAATATGGGATAAGAAATACT
TGCCTGACACTTTTCCATGGCTGAGTCTGACCATTACAGTAAGAACAAGAATTGAAGAGGCATTTTGCACACAGAAACATTCTCACTTTA
AAAAATGGTATTGGTTACCTTGAAGGCATAGATAATGGGCCTGTCATAAAATTATCAATTATAACTGGCACCGAGGGACTGCCCTTTTTA
AGCTAAACTAAGCCTTATCTGCTTAAGGATGTTGAACTGAATCACTCCCTTTACTCATCCTGTGCATATGTGTACAAATGGTCATGTGGA
TCATGTGATGATCATCCATCTTATTTGATTGTATTAATGCATCATGCTAAACATGTAGTACAGGTTAACAATACCAGATTTATGTCCTGT
TCAACAACTCAGTACTCTAAATGTTGTTATGCTTTTAATAAGACCTTCCCAGATAATAATCTTGGAGCTCTTTTCCCAGCTGTCTACCAT
GCATTTGCAACAGGAGGAAGATGTAATGAATATGCAGTATTAAGTTGATTTATGAACAGTGCTTTGATATGCCAAAGGGAAAACTGTCCC
ACTTAAATTAGATTAAGTAGGGTGGCTAAAAATAAATAAAAACACTGGAAATTCTTTCTCTCACTTTCTCTTGATGCAATGAAGGGAATA
TGACACTACAGTATACAGAGTTGTTGTTATATGATGCACAAAATATTTTGATGATTTGAATAAATGTTAACTTTTAATCTGCGCCTTAAT
AATGACTGGTTATCTGTAAATATAGAACAGATACAGATTGTATTTTTCTGTGGGTTTTTGTCCTTTTAGTGATTTTTTTCCAAAAACGAG
AGATGGAATTAACATTGAAAATGGGAAATTTTTCTAACTGAATCAATTGTTACATGAAAAATAAATTTATATAACCCCTTTGTATTGCTC
TTGCTA

>33723_33723_2_GNE-BICC1_GNE_chr9_36246028_ENST00000539208_BICC1_chr10_60380615_ENST00000373886_length(amino acids)=1057AA_BP=146
MIEQDDFDINTRLHTIVRGEDEAAMVESVGLALVKLPDVLNRLKPDIMIVHGDRFDALALATSAALMNIRILHIEGGEVSGTIDDSIRHA
ITKLAHYHVCCTRSAEQHLISMCEDHDRILLAGCPSYDKLLSAKNKDYMSIIRMWLAAAEGKGRSGEDFFQKIMEETNTQIAWPSKLKIG
AKSKKDPHIKVSGKKEDVKEAKEMIMSVLDTKSNRVTLKMDVSHTEHSHVIGKGGNNIKKVMEETGCHIHFPDSNRNNQAEKSNQVSIAG
QPAGVESARVRIRELLPLVLMFELPIAGILQPVPDPNSPSIQHISQTYNISVSFKQRSRMYGATVIVRGSQNNTSAVKEGTAMLLEHLAG
SLASAIPVSTQLDIAAQHHLFMMGRNGSNIKHIMQRTGAQIHFPDPSNPQKKSTVYLQGTIESVCLARQYLMGCLPLVLMFDMKEEIEVD
PQFIAQLMEQLDVFISIKPKPKQPSKSVIVKSVERNALNMYEARKCLLGLESSGVTIATSPSPASCPAGLACPSLDILASAGLGLTGLGL
LGPTTLSLNTSTTPNSLLNALNSSVSPLQSPSSGTPSPTLWAPPLANTSSATGFSAIPHLMIPSTAQATLTNILLSGVPTYGHTAPSPPP
GLTPVDVHINSMQTEGKKISAALNGHAQSPDIKYGAISTSSLGEKVLSANHGDPSIQTSGSEQTSPKSSPTEGCNDAFVEVGMPRSPSHS
GNAGDLKQMMCPSKVSCAKRQTVELLQGTKNSHLHSTDRLLSDPELSATESPLADKKAPGSERAAERAAAAQQNSERAHLAPRSSYVNMQ
AFDYEQKKLLATKAMLKKPVVTEVRTPTNTWSGLGFSKSMPAETIKELRRANHVSYKPTMTTTYEGSSMSLSRSNSREHLGGGSESDNWR
DRNGIGPGSHSEFAASIGSPKRKQNKSTEHYLSSSNYMDCISSLTGSNGCNLNSSFKGSDLPELFSKLGLGKYTDVFQQQEIDLQTFLTL
TDQDLKELGITTFGARRKMLLAISELNKNRRKLFESPNARTSFLEGGASGRLPRQYHSDIASVSGRW

--------------------------------------------------------------
>33723_33723_3_GNE-BICC1_GNE_chr9_36246028_ENST00000543356_BICC1_chr10_60380615_ENST00000373886_length(transcript)=5880nt_BP=601nt
ATGCCTATTGGTGACTGCTCCGTGGCAGCTAAACCAAGAAAACAGCTGCTCTGCTCATTATTTCAAACCACACTAGGGTACAGAGCTCGT
GCTTCGGGATGGAAACCTATGGTTATCTGCAGAGGGAGTCATGCTTTCAAGGACCTCATAAATACATATCGAATGATTGAACAAGATGAC
TTTGACATTAACACCAGGCTACACACAATTGTGAGGGGAGAAGATGAGGCAGCCATGGTGGAGTCAGTAGGCCTGGCCCTAGTGAAGCTG
CCAGATGTCCTTAATCGCCTGAAGCCTGATATCATGATTGTTCATGGAGACAGGTTTGATGCCCTGGCTCTGGCCACATCTGCTGCCTTG
ATGAACATCCGAATCCTTCACATTGAAGGTGGGGAAGTCAGTGGGACCATTGATGACTCTATCAGACATGCCATAACAAAACTGGCTCAT
TATCATGTGTGCTGCACCCGCAGTGCAGAGCAGCACCTGATATCCATGTGTGAGGACCATGATCGCATCCTTTTGGCAGGCTGCCCTTCC
TATGACAAACTTCTCTCAGCCAAGAACAAAGACTACATGAGCATCATTCGCATGTGGCTAGCTGCTGCTGAAGGGAAAGGCAGAAGTGGG
GAAGACTTTTTTCAAAAGATCATGGAGGAAACAAATACGCAGATTGCTTGGCCATCAAAACTGAAGATCGGAGCCAAATCCAAGAAAGAT
CCCCATATTAAGGTTTCTGGAAAGAAAGAAGATGTTAAAGAAGCCAAGGAAATGATCATGTCTGTCTTAGACACAAAAAGCAATCGAGTC
ACACTGAAGATGGATGTTTCACATACAGAACATTCACATGTAATCGGCAAAGGTGGCAACAATATTAAAAAAGTGATGGAAGAAACCGGA
TGCCATATCCACTTTCCAGATTCCAACAGGAATAACCAAGCAGAAAAAAGCAACCAGGTATCTATAGCGGGACAACCAGCAGGAGTAGAA
TCTGCCCGAGTTAGAATTCGGGAGCTGCTTCCTTTGGTGCTGATGTTTGAGCTACCAATTGCTGGAATTCTTCAACCGGTTCCTGATCCT
AATTCCCCCTCTATTCAGCATATATCACAAACGTACAATATTTCAGTATCATTTAAACAGCGTTCCCGAATGTATGGTGCTACTGTCATA
GTACGAGGGTCTCAGAATAACACTAGTGCTGTGAAGGAAGGAACTGCCATGCTGTTAGAACATCTTGCTGGGAGCTTAGCATCAGCTATT
CCTGTGAGCACACAACTAGATATTGCAGCTCAACATCATCTCTTTATGATGGGTCGAAATGGGAGCAACATCAAACATATCATGCAGAGA
ACAGGTGCTCAGATCCACTTTCCTGATCCCAGTAATCCACAAAAGAAATCTACCGTCTACCTCCAGGGCACCATTGAGTCTGTCTGTCTT
GCAAGGCAATATCTCATGGGTTGTCTTCCTCTTGTGTTGATGTTTGATATGAAGGAAGAAATTGAAGTAGATCCACAATTCATTGCGCAG
TTGATGGAACAGCTTGATGTCTTCATCAGTATTAAACCAAAGCCCAAACAGCCAAGCAAGTCTGTGATTGTGAAAAGTGTTGAGCGAAAT
GCCTTAAATATGTATGAAGCAAGGAAATGTCTCCTCGGACTTGAAAGCAGTGGGGTTACCATAGCAACCAGTCCATCCCCAGCATCCTGC
CCTGCCGGCCTGGCATGTCCCAGCCTGGATATCTTAGCTTCAGCAGGCCTTGGACTCACTGGACTAGGTCTTTTGGGACCCACCACCTTA
TCTCTGAACACTTCAACAACCCCAAACTCACTCTTGAATGCTCTTAATAGCTCAGTCAGTCCTTTGCAAAGTCCAAGTTCTGGTACACCC
AGCCCCACATTATGGGCACCCCCACTTGCTAATACTTCAAGTGCCACAGGTTTTTCTGCTATACCACACCTTATGATTCCATCTACTGCC
CAAGCCACATTAACTAATATTTTGTTGTCTGGAGTGCCCACCTATGGGCACACAGCTCCATCTCCCCCTCCTGGCTTGACTCCTGTTGAT
GTCCATATCAACAGTATGCAGACCGAAGGCAAAAAAATCTCTGCTGCTTTAAATGGACATGCACAGTCTCCAGATATAAAATATGGTGCA
ATATCCACTTCATCACTTGGAGAAAAAGTGCTGAGTGCAAATCACGGGGATCCGTCCATCCAGACAAGTGGGTCTGAGCAGACATCTCCC
AAATCAAGCCCCACTGAAGGTTGTAATGATGCTTTTGTTGAAGTAGGCATGCCTCGAAGTCCTTCCCATTCTGGGAATGCTGGTGACTTG
AAACAGATGATGTGTCCCTCCAAGGTTTCCTGTGCCAAAAGGCAGACAGTGGAACTATTGCAAGGCACGAAAAACTCACACTTACACAGC
ACTGACAGGTTGCTCTCAGACCCTGAACTGAGTGCTACCGAAAGCCCTTTGGCTGACAAGAAGGCTCCAGGGAGTGAGCGCGCTGCAGAG
AGGGCAGCAGCTGCCCAGCAAAACTCCGAAAGGGCCCACCTTGCTCCACGGTCATCATATGTCAACATGCAGGCATTTGACTATGAACAG
AAGAAGCTATTAGCCACCAAAGCTATGTTAAAGAAACCAGTGGTGACGGAGGTCAGAACGCCCACAAATACCTGGAGTGGCCTGGGTTTT
TCTAAATCCATGCCAGCTGAAACTATCAAGGAGTTGAGAAGGGCCAATCATGTGTCCTATAAGCCCACAATGACAACCACTTATGAGGGC
TCATCCATGTCCCTTTCACGGTCCAACAGTCGTGAGCACTTGGGAGGTGGAAGCGAATCTGATAACTGGAGAGACCGAAATGGAATTGGA
CCTGGAAGTCATAGTGAATTTGCAGCTTCTATTGGCAGCCCTAAGCGTAAACAAAACAAATCAACGGAACACTATCTCAGCAGTAGCAAT
TACATGGACTGCATTTCCTCGCTGACAGGAAGCAATGGCTGTAACTTAAATAGCTCTTTCAAAGGTTCTGACCTCCCTGAGCTCTTCAGC
AAACTGGGCCTGGGCAAATACACAGATGTTTTCCAGCAACAAGAGATCGATCTTCAGACATTCCTCACTCTCACAGATCAGGATCTGAAG
GAGCTGGGAATAACTACTTTTGGTGCCAGGAGGAAAATGCTGCTTGCAATTTCAGAACTAAATAAAAACCGAAGAAAGCTTTTTGAATCG
CCAAATGCACGCACCTCTTTCCTGGAAGGTGGAGCGAGTGGAAGGCTACCCCGTCAGTATCACTCAGACATTGCTAGTGTCAGTGGCCGC
TGGTAGCAGCACCCTCTTGGCACATGCCCGCTGACTAACTGTAAAGTGGACACAGGAGATGTATGAACAGCCTTCACAGCACACCATCCT
TAGCACTCTGGGTGTCTGGTATCAGGACCAAAGCATTTTATTCGCACCTGTACTTTATGGCAAAAAGGAAGAAGAGAGAGAAGATGTTCT
TATGATGTCATACAGAACACCAAATATGGATTACTTTTTTAAAATGGCAGTTGGACAGAATTTGCAATATAAGGATAGGGCTTTATTTCC
TGTTTTTATTTACCTATATAACATATGCACTGATGATTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTACTTAAAATGAAGGATGAATTGA
CATCTGGGATGCCAGAAGACTTAGAAGTTATTTTGTTTGCTTGTTTTGTTTGGGTATTTGGGGATTTTTAAAAAATAATCAAAGTGGAAT
TTTCTGGTACTGCTTTAAAATAATTATTGTGGTCTTTCAGCACTTTACACGTTCTAATTTCTTGTCCTATGGAAGTTCTCGCTGTCTCCA
TCTCTCTCATTTTTGTGTCACCTAATATGTTGGTACAGATAAGAGTTAGTCACATTTTTCTGACTGCATCAAACTTTTATTTGAAATGGT
ACTGGATCTTAGTTTCTGTGCAGAATATTCTGTGATTTTGGGAAATGTAAGTGAGTCCACTTGCTTCTGGACCAATTCTGTTTCATGTAT
GTTAGCATCCTAGAAACACCTAGCAATGGACCTAGTTCACAGTAATAGGTGCAAAGAAAGACCAAATGGACTTTGCAGTATTAACCCTTT
GCAGTCGTCATACTTAGCTGCTGCCTGTAATGCTAAAATGATTTTAATGGTTGTCTGGAGGCAAAGGGCTGTTTTTTAGTATATTGCCAC
TAAAGGACATTTATTTATATCAAACTTTTATTTTTAGATATTATAAGCATACAGTACATAATTGATGAAATTGATATTTACTAGAGATTT
ATGGTAGAGAATGGACGACATTCAATAACTGGAGCCCGAGATTGTCACTTTATTTAAAAAGACAAATAATCATCTGACAAGACAGCACTG
TTGCCATTATAAGGAGAAATAGATTACAATCCTTATCATGTACACGTTAGCTATGTTCCGTATGGCCACAGGACTTTCCTGAAACCGTAT
CTGTCTGCTTGAAGTAGACTTATGTTTGTTGAGAATGAACAGGCTTATTTGAGCCTCCAGGGTGGCAGTTCATAAAGACAGCTAAGTTCT
GAAGGAAAAAAAAAATATATCTTTTTAAGTGGCTAGAGTCATTATTACAATCTTATACTGTGAAAGTCCAAGAAATCAGGCAACATTGTT
TCCTGGGTCTTTTCAGAGATCTTATAGATTTATGAAGTGTTTTTAATCCATGAAGAAACACTAAAGTGCCTTTCTTTCTTCAAAGCAATA
TTATTTCCAAGTATATTAATTTGTTAGAAAACTTTCCCATAGGAAATGTTGTCAAGTTACCTGTACTGTAAAGAGTTATTTATGTTCAGT
AGTCAAGATTTTCTACATGGACATAAACCACTCTCACGTGCTCTCAGCAGAAGGCATTAGATAAGCATATACAAGAATTGGGTACTTTTA
TACAAATATGGGATAAGAAATACTTGCCTGACACTTTTCCATGGCTGAGTCTGACCATTACAGTAAGAACAAGAATTGAAGAGGCATTTT
GCACACAGAAACATTCTCACTTTAAAAAATGGTATTGGTTACCTTGAAGGCATAGATAATGGGCCTGTCATAAAATTATCAATTATAACT
GGCACCGAGGGACTGCCCTTTTTAAGCTAAACTAAGCCTTATCTGCTTAAGGATGTTGAACTGAATCACTCCCTTTACTCATCCTGTGCA
TATGTGTACAAATGGTCATGTGGATCATGTGATGATCATCCATCTTATTTGATTGTATTAATGCATCATGCTAAACATGTAGTACAGGTT
AACAATACCAGATTTATGTCCTGTTCAACAACTCAGTACTCTAAATGTTGTTATGCTTTTAATAAGACCTTCCCAGATAATAATCTTGGA
GCTCTTTTCCCAGCTGTCTACCATGCATTTGCAACAGGAGGAAGATGTAATGAATATGCAGTATTAAGTTGATTTATGAACAGTGCTTTG
ATATGCCAAAGGGAAAACTGTCCCACTTAAATTAGATTAAGTAGGGTGGCTAAAAATAAATAAAAACACTGGAAATTCTTTCTCTCACTT
TCTCTTGATGCAATGAAGGGAATATGACACTACAGTATACAGAGTTGTTGTTATATGATGCACAAAATATTTTGATGATTTGAATAAATG
TTAACTTTTAATCTGCGCCTTAATAATGACTGGTTATCTGTAAATATAGAACAGATACAGATTGTATTTTTCTGTGGGTTTTTGTCCTTT
TAGTGATTTTTTTCCAAAAACGAGAGATGGAATTAACATTGAAAATGGGAAATTTTTCTAACTGAATCAATTGTTACATGAAAAATAAAT
TTATATAACCCCTTTGTATTGCTCTTGCTA

>33723_33723_3_GNE-BICC1_GNE_chr9_36246028_ENST00000543356_BICC1_chr10_60380615_ENST00000373886_length(amino acids)=1111AA_BP=200
MPIGDCSVAAKPRKQLLCSLFQTTLGYRARASGWKPMVICRGSHAFKDLINTYRMIEQDDFDINTRLHTIVRGEDEAAMVESVGLALVKL
PDVLNRLKPDIMIVHGDRFDALALATSAALMNIRILHIEGGEVSGTIDDSIRHAITKLAHYHVCCTRSAEQHLISMCEDHDRILLAGCPS
YDKLLSAKNKDYMSIIRMWLAAAEGKGRSGEDFFQKIMEETNTQIAWPSKLKIGAKSKKDPHIKVSGKKEDVKEAKEMIMSVLDTKSNRV
TLKMDVSHTEHSHVIGKGGNNIKKVMEETGCHIHFPDSNRNNQAEKSNQVSIAGQPAGVESARVRIRELLPLVLMFELPIAGILQPVPDP
NSPSIQHISQTYNISVSFKQRSRMYGATVIVRGSQNNTSAVKEGTAMLLEHLAGSLASAIPVSTQLDIAAQHHLFMMGRNGSNIKHIMQR
TGAQIHFPDPSNPQKKSTVYLQGTIESVCLARQYLMGCLPLVLMFDMKEEIEVDPQFIAQLMEQLDVFISIKPKPKQPSKSVIVKSVERN
ALNMYEARKCLLGLESSGVTIATSPSPASCPAGLACPSLDILASAGLGLTGLGLLGPTTLSLNTSTTPNSLLNALNSSVSPLQSPSSGTP
SPTLWAPPLANTSSATGFSAIPHLMIPSTAQATLTNILLSGVPTYGHTAPSPPPGLTPVDVHINSMQTEGKKISAALNGHAQSPDIKYGA
ISTSSLGEKVLSANHGDPSIQTSGSEQTSPKSSPTEGCNDAFVEVGMPRSPSHSGNAGDLKQMMCPSKVSCAKRQTVELLQGTKNSHLHS
TDRLLSDPELSATESPLADKKAPGSERAAERAAAAQQNSERAHLAPRSSYVNMQAFDYEQKKLLATKAMLKKPVVTEVRTPTNTWSGLGF
SKSMPAETIKELRRANHVSYKPTMTTTYEGSSMSLSRSNSREHLGGGSESDNWRDRNGIGPGSHSEFAASIGSPKRKQNKSTEHYLSSSN
YMDCISSLTGSNGCNLNSSFKGSDLPELFSKLGLGKYTDVFQQQEIDLQTFLTLTDQDLKELGITTFGARRKMLLAISELNKNRRKLFES
PNARTSFLEGGASGRLPRQYHSDIASVSGRW

--------------------------------------------------------------

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Fusion Gene PPI Analysis for GNE-BICC1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for GNE-BICC1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for GNE-BICC1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneGNEC1853926NONAKA MYOPATHY16CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
HgeneGNEC0342853Sialuria4CTD_human;GENOMICS_ENGLAND;UNIPROT
HgeneGNEC1833373Inclusion Body Myopathy, Autosomal Recessive2CTD_human;ORPHANET
HgeneGNEC0238190Inclusion Body Myositis (disorder)1CTD_human
HgeneGNEC0686353Muscular Dystrophies, Limb-Girdle1GENOMICS_ENGLAND
HgeneGNEC0751336Distal Muscular Dystrophies1GENOMICS_ENGLAND
HgeneGNEC0751713Inclusion Body Myopathy, Sporadic1CTD_human
TgeneC0011570Mental Depression2PSYGENET
TgeneC0011581Depressive disorder2PSYGENET
TgeneC0085413Polycystic Kidney, Autosomal Dominant1ORPHANET
TgeneC3275898RENAL DYSPLASIA, CYSTIC, SUSCEPTIBILITY TO1GENOMICS_ENGLAND;UNIPROT