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![]() | Fusion Gene Summary |
![]() | Fusion Gene ORF analysis |
![]() | Fusion Genomic Features |
![]() | Fusion Protein Features |
![]() | Fusion Gene Sequence |
![]() | Fusion Gene PPI analysis |
![]() | Related Drugs |
![]() | Related Diseases |
Fusion gene:CDH4-DPPA3 (FusionGDB2 ID:HG1002TG359787) |
Fusion Gene Summary for CDH4-DPPA3 |
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Fusion gene information | Fusion gene name: CDH4-DPPA3 | Fusion gene ID: hg1002tg359787 | Hgene | Tgene | Gene symbol | CDH4 | DPPA3 | Gene ID | 1002 | 359787 |
Gene name | cadherin 4 | developmental pluripotency associated 3 | |
Synonyms | CAD4|R-CAD|RCAD | Pgc7|STELLA | |
Cytomap | ('CDH4')('DPPA3') 20q13.33 | 12p13.31 | |
Type of gene | protein-coding | protein-coding | |
Description | cadherin-4R-cadherincadherin 4, type 1, R-cadherin (retinal)cadherin 4, type 1, preproproteinretinal cadherin | developmental pluripotency-associated protein 3stella-related protein | |
Modification date | 20200313 | 20200313 | |
UniProtAcc | P55283 | . | |
Ensembl transtripts involved in fusion gene | ENST00000360469, ENST00000543233, | ||
Fusion gene scores | * DoF score | 7 X 6 X 4=168 | 1 X 2 X 1=2 |
# samples | 9 | 2 | |
** MAII score | log2(9/168*10)=-0.900464326449086 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(2/2*10)=3.32192809488736 | |
Context | PubMed: CDH4 [Title/Abstract] AND DPPA3 [Title/Abstract] AND fusion [Title/Abstract] | ||
Most frequent breakpoint | CDH4(60448956)-DPPA3(7867779), # samples:2 | ||
Anticipated loss of major functional domain due to fusion event. | CDH4-DPPA3 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. CDH4-DPPA3 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. CDH4-DPPA3 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. CDH4-DPPA3 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. CDH4-DPPA3 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF. CDH4-DPPA3 seems lost the major protein functional domain in Hgene partner, which is a tumor suppressor due to the frame-shifted ORF. CDH4-DPPA3 seems lost the major protein functional domain in Tgene partner, which is a epigenetic factor due to the frame-shifted ORF. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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![]() * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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![]() * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChimerDB4 | SARC | TCGA-DX-A1KZ-01A | CDH4 | chr20 | 60448956 | + | DPPA3 | chr12 | 7867779 | + |
ChimerDB4 | SARC | TCGA-RN-AAAQ-01A | CDH4 | chr20 | 60448956 | + | DPPA3 | chr12 | 7867779 | + |
ChimerDB4 | SARC | TCGA-RN-AAAQ-01A | CDH4 | chr20 | 60448956 | + | DPPA3 | chr12 | 7868794 | + |
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Fusion Gene ORF analysis for CDH4-DPPA3 |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
Frame-shift | ENST00000360469 | ENST00000345088 | CDH4 | chr20 | 60448956 | + | DPPA3 | chr12 | 7867779 | + |
Frame-shift | ENST00000543233 | ENST00000345088 | CDH4 | chr20 | 60448956 | + | DPPA3 | chr12 | 7867779 | + |
In-frame | ENST00000360469 | ENST00000345088 | CDH4 | chr20 | 60448956 | + | DPPA3 | chr12 | 7868794 | + |
In-frame | ENST00000543233 | ENST00000345088 | CDH4 | chr20 | 60448956 | + | DPPA3 | chr12 | 7868794 | + |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
ENST00000360469 | CDH4 | chr20 | 60448956 | + | ENST00000345088 | DPPA3 | chr12 | 7868794 | + | 1773 | 1138 | 88 | 1290 | 400 |
ENST00000543233 | CDH4 | chr20 | 60448956 | + | ENST00000345088 | DPPA3 | chr12 | 7868794 | + | 1728 | 1093 | 265 | 1245 | 326 |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
ENST00000360469 | ENST00000345088 | CDH4 | chr20 | 60448956 | + | DPPA3 | chr12 | 7868794 | + | 0.000772029 | 0.999228 |
ENST00000543233 | ENST00000345088 | CDH4 | chr20 | 60448956 | + | DPPA3 | chr12 | 7868794 | + | 0.002011766 | 0.9979882 |
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Fusion Genomic Features for CDH4-DPPA3 |
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Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
CDH4 | chr20 | 60448956 | + | DPPA3 | chr12 | 7867778 | + | 0.000576383 | 0.9994236 |
CDH4 | chr20 | 60448956 | + | DPPA3 | chr12 | 7867778 | + | 0.000576383 | 0.9994236 |
CDH4 | chr20 | 60448956 | + | DPPA3 | chr12 | 7868793 | + | 1.65E-05 | 0.99998355 |
CDH4 | chr20 | 60448956 | + | DPPA3 | chr12 | 7867778 | + | 0.000576383 | 0.9994236 |
CDH4 | chr20 | 60448956 | + | DPPA3 | chr12 | 7867778 | + | 0.000576383 | 0.9994236 |
CDH4 | chr20 | 60448956 | + | DPPA3 | chr12 | 7868793 | + | 1.65E-05 | 0.99998355 |
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Fusion Protein Features for CDH4-DPPA3 |
![]() Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr20:60448956/chr12:7867779) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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Hgene | Tgene |
CDH4 | . |
FUNCTION: Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. May play an important role in retinal development. | FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | CDH4 | chr20:60448956 | chr12:7868794 | ENST00000360469 | + | 7 | 16 | 170_277 | 350 | 917.0 | Domain | Cadherin 1 |
Hgene | CDH4 | chr20:60448956 | chr12:7868794 | ENST00000543233 | + | 6 | 15 | 170_277 | 276 | 843.0 | Domain | Cadherin 1 |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | CDH4 | chr20:60448956 | chr12:7868794 | ENST00000360469 | + | 7 | 16 | 873_888 | 350 | 917.0 | Compositional bias | Note=Ser-rich |
Hgene | CDH4 | chr20:60448956 | chr12:7868794 | ENST00000543233 | + | 6 | 15 | 873_888 | 276 | 843.0 | Compositional bias | Note=Ser-rich |
Hgene | CDH4 | chr20:60448956 | chr12:7868794 | ENST00000360469 | + | 7 | 16 | 278_392 | 350 | 917.0 | Domain | Cadherin 2 |
Hgene | CDH4 | chr20:60448956 | chr12:7868794 | ENST00000360469 | + | 7 | 16 | 393_507 | 350 | 917.0 | Domain | Cadherin 3 |
Hgene | CDH4 | chr20:60448956 | chr12:7868794 | ENST00000360469 | + | 7 | 16 | 508_613 | 350 | 917.0 | Domain | Cadherin 4 |
Hgene | CDH4 | chr20:60448956 | chr12:7868794 | ENST00000360469 | + | 7 | 16 | 614_724 | 350 | 917.0 | Domain | Cadherin 5 |
Hgene | CDH4 | chr20:60448956 | chr12:7868794 | ENST00000543233 | + | 6 | 15 | 278_392 | 276 | 843.0 | Domain | Cadherin 2 |
Hgene | CDH4 | chr20:60448956 | chr12:7868794 | ENST00000543233 | + | 6 | 15 | 393_507 | 276 | 843.0 | Domain | Cadherin 3 |
Hgene | CDH4 | chr20:60448956 | chr12:7868794 | ENST00000543233 | + | 6 | 15 | 508_613 | 276 | 843.0 | Domain | Cadherin 4 |
Hgene | CDH4 | chr20:60448956 | chr12:7868794 | ENST00000543233 | + | 6 | 15 | 614_724 | 276 | 843.0 | Domain | Cadherin 5 |
Hgene | CDH4 | chr20:60448956 | chr12:7868794 | ENST00000360469 | + | 7 | 16 | 170_734 | 350 | 917.0 | Topological domain | Extracellular |
Hgene | CDH4 | chr20:60448956 | chr12:7868794 | ENST00000360469 | + | 7 | 16 | 757_916 | 350 | 917.0 | Topological domain | Cytoplasmic |
Hgene | CDH4 | chr20:60448956 | chr12:7868794 | ENST00000543233 | + | 6 | 15 | 170_734 | 276 | 843.0 | Topological domain | Extracellular |
Hgene | CDH4 | chr20:60448956 | chr12:7868794 | ENST00000543233 | + | 6 | 15 | 757_916 | 276 | 843.0 | Topological domain | Cytoplasmic |
Hgene | CDH4 | chr20:60448956 | chr12:7868794 | ENST00000360469 | + | 7 | 16 | 735_756 | 350 | 917.0 | Transmembrane | Helical |
Hgene | CDH4 | chr20:60448956 | chr12:7868794 | ENST00000543233 | + | 6 | 15 | 735_756 | 276 | 843.0 | Transmembrane | Helical |
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Fusion Gene Sequence for CDH4-DPPA3 |
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>15083_15083_1_CDH4-DPPA3_CDH4_chr20_60448956_ENST00000360469_DPPA3_chr12_7868794_ENST00000345088_length(transcript)=1773nt_BP=1138nt AGCGGCGGCGGTGGTCTCGGCGGCGGCGGCGGCGGCGGCGGCAGGGAGCGGGCTCCCGGTGCCGGGCACCGGGCGGGCGGCGGGGAAGAT GACCGCGGGCGCCGGCGTGCTCCTTCTGCTGCTCTCGCTCTCCGGCGCGCTCCGGGCCCATAATGAGGATCTTACAACTAGAGAGACCTG CAAGGCTGGGTTCTCTGAAGATGATTACACGGCATTAATCTCCCAAAATATTCTAGAAGGGGAAAAGCTACTTCAAGTCAAGTTCAGCAG CTGTGTGGGGACCAAGGGGACACAATATGAGACCAACAGCATGGACTTCAAAGTTGGGGCAGATGGGACAGTCTTCGCCACCCGGGAGCT GCAGGTCCCCTCCGAGCAGGTGGCGTTCACGGTGACTGCATGGGACAGCCAGACAGCAGAGAAATGGGACGCCGTGGTGCGGTTGCTGGT GGCCCAGACCTCGTCCCCGCACTCTGGACACAAGCCGCAGAAAGGAAAGAAGGTCGTGGCTCTGGACCCCTCTCCGCCTCCGAAGGACAC CCTGCTGCCGTGGCCCCAGCACCAGAACGCCAACGGGCTGAGGCGGCGCAAACGGGACTGGGTCATCCCGCCCATCAACGTGCCCGAGAA CTCGCGCGGGCCCTTCCCGCAGCAGCTCGTGAGGATCCGGTCCGACAAAGACAATGACATCCCCATCCGGTACAGCATCACGGGAGTGGG CGCCGACCAGCCCCCCATGGAGGTCTTCAGCATTGACTCCATGTCCGGCCGGATGTACGTCACAAGGCCCATGGACCGGGAGGAGCACGC CTCTTACCACCTCCGAGCCCACGCTGTGGACATGAATGGCAACAAGGTGGAGAACCCCATCGACCTGTACATCTACGTCATCGACATGAA TGACAACCGCCCTGAGTTCATCAACCAGGTCTACAACGGCTCCGTGGACGAGGGCTCCAAGCCAGGCACCTACGTGATGACCGTCACGGC CAACGATGCTGACGACAGCACCACGGCCAACGGGATGGTGCGGTACCGGATCGTGACCCAGACCCCACAGAGCCCGTCCCAGAATATGTT CACCATCAACAGCGAGACTGGAGATATCGTCACAGTGGCGGCTGGCCTGGACCGAGAGCATGAAAGAAGACCAACAAACAAGGAGCCTAA GGGAGTTAAGAAGGAATCAAGACCATTCAAATGTCCCTGCAGTTTCTGCGTGTCTAATGGATGGGATCCTTCTGAGAATGCTAGAATAGG GAATCAAGACACCAAGCCACTTCAGCCATAAATCTTATTCTTGCACCTTTTTTTCTTGGTAGTAATTTTATATAGCAGGTTGAGAAAGCT ACTCTATGCTAGTATAGACTATACACCAATAATTTTGATAATGAGTTCTAGGATGTATTTTTCTTGTATCTTTTTCTTCCTACTATGATA CTAGTAATTCATAAGGGATCTGTGTAATCTGAATGTATTTGAATAACTTTAGCTCTACTGTTTGATTTGACCCAAAGAAGCCAAGATGAT ATAAGTATTCCCATGTGTCTTAGAAGCCCAAAGTCAGTGAGATGAAACCCAACATCAAGAAATTGAAGCAAAGTTACTTATGGATAAAGA AAGCATTAGGTAGTTGGGCTATAGCATAATTAGATTTTCTGGCTTTCAAAAATTTGGATTGCAATCACAGCAAACTTTGTTATTTTTACA >15083_15083_1_CDH4-DPPA3_CDH4_chr20_60448956_ENST00000360469_DPPA3_chr12_7868794_ENST00000345088_length(amino acids)=400AA_BP=350 MTAGAGVLLLLLSLSGALRAHNEDLTTRETCKAGFSEDDYTALISQNILEGEKLLQVKFSSCVGTKGTQYETNSMDFKVGADGTVFATRE LQVPSEQVAFTVTAWDSQTAEKWDAVVRLLVAQTSSPHSGHKPQKGKKVVALDPSPPPKDTLLPWPQHQNANGLRRRKRDWVIPPINVPE NSRGPFPQQLVRIRSDKDNDIPIRYSITGVGADQPPMEVFSIDSMSGRMYVTRPMDREEHASYHLRAHAVDMNGNKVENPIDLYIYVIDM NDNRPEFINQVYNGSVDEGSKPGTYVMTVTANDADDSTTANGMVRYRIVTQTPQSPSQNMFTINSETGDIVTVAAGLDREHERRPTNKEP -------------------------------------------------------------- >15083_15083_2_CDH4-DPPA3_CDH4_chr20_60448956_ENST00000543233_DPPA3_chr12_7868794_ENST00000345088_length(transcript)=1728nt_BP=1093nt TTCTTCTTTCTCCCTCTGCCTTAATGATGCTGCCCCTTTCCTGTTCCTGGTTGAAGCTGAAGCCCGCTTCCCTTCGCCGCACACAACACA GGAGCAATCTTCTCAGCCGTGCACTCACAGCTTGGAAAATAAAGGGAGGAAGGAGTCCCAGCCACAGGGTAGAGGAACGGCCTCTCCACA GAGAAGCTGCTGCTGCTGAGCTGAAGTGACAGTCAAGTTCAGCAGCTGTGTGGGGACCAAGGGGACACAATATGAGACCAACAGCATGGA CTTCAAAGTTGGGGCAGATGGGACAGTCTTCGCCACCCGGGAGCTGCAGGTCCCCTCCGAGCAGGTGGCGTTCACGGTGACTGCATGGGA CAGCCAGACAGCAGAGAAATGGGACGCCGTGGTGCGGTTGCTGGTGGCCCAGACCTCGTCCCCGCACTCTGGACACAAGCCGCAGAAAGG AAAGAAGGTCGTGGCTCTGGACCCCTCTCCGCCTCCGAAGGACACCCTGCTGCCGTGGCCCCAGCACCAGAACGCCAACGGGCTGAGGCG GCGCAAACGGGACTGGGTCATCCCGCCCATCAACGTGCCCGAGAACTCGCGCGGGCCCTTCCCGCAGCAGCTCGTGAGGATCCGGTCCGA CAAAGACAATGACATCCCCATCCGGTACAGCATCACGGGAGTGGGCGCCGACCAGCCCCCCATGGAGGTCTTCAGCATTGACTCCATGTC CGGCCGGATGTACGTCACAAGGCCCATGGACCGGGAGGAGCACGCCTCTTACCACCTCCGAGCCCACGCTGTGGACATGAATGGCAACAA GGTGGAGAACCCCATCGACCTGTACATCTACGTCATCGACATGAATGACAACCGCCCTGAGTTCATCAACCAGGTCTACAACGGCTCCGT GGACGAGGGCTCCAAGCCAGGCACCTACGTGATGACCGTCACGGCCAACGATGCTGACGACAGCACCACGGCCAACGGGATGGTGCGGTA CCGGATCGTGACCCAGACCCCACAGAGCCCGTCCCAGAATATGTTCACCATCAACAGCGAGACTGGAGATATCGTCACAGTGGCGGCTGG CCTGGACCGAGAGCATGAAAGAAGACCAACAAACAAGGAGCCTAAGGGAGTTAAGAAGGAATCAAGACCATTCAAATGTCCCTGCAGTTT CTGCGTGTCTAATGGATGGGATCCTTCTGAGAATGCTAGAATAGGGAATCAAGACACCAAGCCACTTCAGCCATAAATCTTATTCTTGCA CCTTTTTTTCTTGGTAGTAATTTTATATAGCAGGTTGAGAAAGCTACTCTATGCTAGTATAGACTATACACCAATAATTTTGATAATGAG TTCTAGGATGTATTTTTCTTGTATCTTTTTCTTCCTACTATGATACTAGTAATTCATAAGGGATCTGTGTAATCTGAATGTATTTGAATA ACTTTAGCTCTACTGTTTGATTTGACCCAAAGAAGCCAAGATGATATAAGTATTCCCATGTGTCTTAGAAGCCCAAAGTCAGTGAGATGA AACCCAACATCAAGAAATTGAAGCAAAGTTACTTATGGATAAAGAAAGCATTAGGTAGTTGGGCTATAGCATAATTAGATTTTCTGGCTT TCAAAAATTTGGATTGCAATCACAGCAAACTTTGTTATTTTTACAGTTTTCAGTACAAAAGTGTTTATATAGAAACAATAAAGTTGACAT >15083_15083_2_CDH4-DPPA3_CDH4_chr20_60448956_ENST00000543233_DPPA3_chr12_7868794_ENST00000345088_length(amino acids)=326AA_BP=276 MDFKVGADGTVFATRELQVPSEQVAFTVTAWDSQTAEKWDAVVRLLVAQTSSPHSGHKPQKGKKVVALDPSPPPKDTLLPWPQHQNANGL RRRKRDWVIPPINVPENSRGPFPQQLVRIRSDKDNDIPIRYSITGVGADQPPMEVFSIDSMSGRMYVTRPMDREEHASYHLRAHAVDMNG NKVENPIDLYIYVIDMNDNRPEFINQVYNGSVDEGSKPGTYVMTVTANDADDSTTANGMVRYRIVTQTPQSPSQNMFTINSETGDIVTVA -------------------------------------------------------------- |
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Fusion Gene PPI Analysis for CDH4-DPPA3 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for CDH4-DPPA3 |
![]() (DrugBank Version 5.1.8 2021-05-08) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for CDH4-DPPA3 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | C0027654 | Embryonal Neoplasm | 1 | CTD_human | |
Tgene | C0027658 | Neoplasms, Germ Cell and Embryonal | 1 | CTD_human | |
Tgene | C0205851 | Germ cell tumor | 1 | CTD_human | |
Tgene | C0205852 | Neoplasms, Embryonal and Mixed | 1 | CTD_human | |
Tgene | C0740345 | Germ Cell Cancer | 1 | CTD_human | |
Tgene | C0751364 | Cancer, Embryonal | 1 | CTD_human | |
Tgene | C0751365 | Cancer, Embryonal and Mixed | 1 | CTD_human |