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![]() | Fusion Gene Summary |
![]() | Fusion Gene ORF analysis |
![]() | Fusion Genomic Features |
![]() | Fusion Protein Features |
![]() | Fusion Gene Sequence |
![]() | Fusion Gene PPI analysis |
![]() | Related Drugs |
![]() | Related Diseases |
Fusion gene:HMGXB4-MGMT (FusionGDB2 ID:HG10042TG4255) |
Fusion Gene Summary for HMGXB4-MGMT |
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Fusion gene information | Fusion gene name: HMGXB4-MGMT | Fusion gene ID: hg10042tg4255 | Hgene | Tgene | Gene symbol | HMGXB4 | MGMT | Gene ID | 10042 | 4255 |
Gene name | HMG-box containing 4 | O-6-methylguanine-DNA methyltransferase | |
Synonyms | HMG2L1|HMGBCG|THC211630 | - | |
Cytomap | ('HMGXB4')('MGMT') 22q12.3 | 10q26.3 | |
Type of gene | protein-coding | protein-coding | |
Description | HMG domain-containing protein 4HMG box domain containing 4HMG box-containing protein 4high mobility group protein 2-like 1 | methylated-DNA--protein-cysteine methyltransferase6-O-methylguanine-DNA methyltransferaseO-6-methylguanine-DNA-alkyltransferaseO6-methylguanine-DNA methyltransferasemethylguanine-DNA methyltransferase | |
Modification date | 20200313 | 20200315 | |
UniProtAcc | . | P16455 | |
Ensembl transtripts involved in fusion gene | ENST00000466438, ENST00000216106, ENST00000444518, | ||
Fusion gene scores | * DoF score | 2 X 2 X 2=8 | 19 X 11 X 7=1463 |
# samples | 2 | 18 | |
** MAII score | log2(2/8*10)=1.32192809488736 | log2(18/1463*10)=-3.02286095780881 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: HMGXB4 [Title/Abstract] AND MGMT [Title/Abstract] AND fusion [Title/Abstract] | ||
Most frequent breakpoint | HMGXB4(35653550)-MGMT(131506159), # samples:3 | ||
Anticipated loss of major functional domain due to fusion event. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | MGMT | GO:0043066 | negative regulation of apoptotic process | 24147153 |
Tgene | MGMT | GO:2000781 | positive regulation of double-strand break repair | 24147153 |
![]() * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChimerDB4 | SKCM | TCGA-W3-AA1R-06A | HMGXB4 | chr22 | 35653550 | + | MGMT | chr10 | 131445026 | + |
ChimerDB4 | SKCM | TCGA-W3-AA1R-06A | HMGXB4 | chr22 | 35653550 | - | MGMT | chr10 | 131506159 | + |
ChimerDB4 | SKCM | TCGA-W3-AA1R-06A | HMGXB4 | chr22 | 35653550 | + | MGMT | chr10 | 131506159 | + |
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Fusion Gene ORF analysis for HMGXB4-MGMT |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
3UTR-3CDS | ENST00000466438 | ENST00000306010 | HMGXB4 | chr22 | 35653550 | + | MGMT | chr10 | 131506159 | + |
3UTR-3UTR | ENST00000466438 | ENST00000462672 | HMGXB4 | chr22 | 35653550 | + | MGMT | chr10 | 131506159 | + |
3UTR-intron | ENST00000466438 | ENST00000306010 | HMGXB4 | chr22 | 35653550 | + | MGMT | chr10 | 131445026 | + |
3UTR-intron | ENST00000466438 | ENST00000462672 | HMGXB4 | chr22 | 35653550 | + | MGMT | chr10 | 131445026 | + |
5UTR-3CDS | ENST00000216106 | ENST00000306010 | HMGXB4 | chr22 | 35653550 | + | MGMT | chr10 | 131506159 | + |
5UTR-3CDS | ENST00000444518 | ENST00000306010 | HMGXB4 | chr22 | 35653550 | + | MGMT | chr10 | 131506159 | + |
5UTR-3UTR | ENST00000216106 | ENST00000462672 | HMGXB4 | chr22 | 35653550 | + | MGMT | chr10 | 131506159 | + |
5UTR-3UTR | ENST00000444518 | ENST00000462672 | HMGXB4 | chr22 | 35653550 | + | MGMT | chr10 | 131506159 | + |
5UTR-intron | ENST00000216106 | ENST00000306010 | HMGXB4 | chr22 | 35653550 | + | MGMT | chr10 | 131445026 | + |
5UTR-intron | ENST00000216106 | ENST00000462672 | HMGXB4 | chr22 | 35653550 | + | MGMT | chr10 | 131445026 | + |
5UTR-intron | ENST00000444518 | ENST00000306010 | HMGXB4 | chr22 | 35653550 | + | MGMT | chr10 | 131445026 | + |
5UTR-intron | ENST00000444518 | ENST00000462672 | HMGXB4 | chr22 | 35653550 | + | MGMT | chr10 | 131445026 | + |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
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Fusion Genomic Features for HMGXB4-MGMT |
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Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
HMGXB4 | chr22 | 35653550 | + | MGMT | chr10 | 131506158 | + | 6.35E-07 | 0.9999994 |
HMGXB4 | chr22 | 35653550 | + | MGMT | chr10 | 131506158 | + | 6.35E-07 | 0.9999994 |
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Fusion Protein Features for HMGXB4-MGMT |
![]() Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:35653550/:131506159) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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Hgene | Tgene |
. | MGMT |
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. | FUNCTION: Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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Fusion Gene Sequence for HMGXB4-MGMT |
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Fusion Gene PPI Analysis for HMGXB4-MGMT |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for HMGXB4-MGMT |
![]() (DrugBank Version 5.1.8 2021-05-08) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Tgene | MGMT | P16455 | DB14548 | Zinc sulfate, unspecified form | Stabilization | Small molecule | Approved|Experimental |
Tgene | MGMT | P16455 | DB01593 | Zinc | Small molecule | Approved|Investigational | |
Tgene | MGMT | P16455 | DB14487 | Zinc acetate | Small molecule | Approved|Investigational | |
Tgene | MGMT | P16455 | DB14533 | Zinc chloride | Stabilization | Small molecule | Approved|Investigational |
Tgene | MGMT | P16455 | DB00151 | Cysteine | Small molecule | Approved|Nutraceutical |
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Related Diseases for HMGXB4-MGMT |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | HMGXB4 | C0005586 | Bipolar Disorder | 1 | PSYGENET |
Hgene | HMGXB4 | C1839839 | MAJOR AFFECTIVE DISORDER 2 | 1 | PSYGENET |
Tgene | C0334588 | Giant Cell Glioblastoma | 4 | CTD_human;ORPHANET | |
Tgene | C0017638 | Glioma | 3 | CTD_human | |
Tgene | C0259783 | mixed gliomas | 3 | CTD_human | |
Tgene | C0555198 | Malignant Glioma | 3 | CTD_human | |
Tgene | C0017636 | Glioblastoma | 2 | CTD_human | |
Tgene | C0206726 | gliosarcoma | 2 | ORPHANET | |
Tgene | C1621958 | Glioblastoma Multiforme | 2 | CTD_human | |
Tgene | C0006118 | Brain Neoplasms | 1 | CTD_human | |
Tgene | C0023418 | leukemia | 1 | CTD_human | |
Tgene | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human | |
Tgene | C0026640 | Mouth Neoplasms | 1 | CTD_human | |
Tgene | C0027540 | Necrosis | 1 | CTD_human | |
Tgene | C0032927 | Precancerous Conditions | 1 | CTD_human | |
Tgene | C0153381 | Malignant neoplasm of mouth | 1 | CTD_human | |
Tgene | C0153633 | Malignant neoplasm of brain | 1 | CTD_human | |
Tgene | C0279626 | Squamous cell carcinoma of esophagus | 1 | CTD_human | |
Tgene | C0282313 | Condition, Preneoplastic | 1 | CTD_human | |
Tgene | C0496899 | Benign neoplasm of brain, unspecified | 1 | CTD_human | |
Tgene | C0750974 | Brain Tumor, Primary | 1 | CTD_human | |
Tgene | C0750977 | Recurrent Brain Neoplasm | 1 | CTD_human | |
Tgene | C0750979 | Primary malignant neoplasm of brain | 1 | CTD_human | |
Tgene | C1168401 | Squamous cell carcinoma of the head and neck | 1 | CTD_human | |
Tgene | C1449861 | Micronuclei, Chromosome-Defective | 1 | CTD_human | |
Tgene | C1449862 | Micronuclei, Genotoxicant-Induced | 1 | CTD_human | |
Tgene | C1527390 | Neoplasms, Intracranial | 1 | CTD_human | |
Tgene | C2314896 | Familial Atypical Mole Melanoma Syndrome | 1 | ORPHANET |