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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Fusion gene:ABCC5-GCN1L1 (FusionGDB2 ID:HG10057TG10985)

Fusion Gene Summary for ABCC5-GCN1L1

check button Fusion gene summary
Fusion gene informationFusion gene name: ABCC5-GCN1L1
Fusion gene ID: hg10057tg10985
HgeneTgene
Gene symbol

ABCC5

GCN1L1

Gene ID

10057

10985

Gene nameATP binding cassette subfamily C member 5GCN1 activator of EIF2AK4
SynonymsABC33|EST277145|MOAT-C|MOATC|MRP5|SMRP|pABC11GCN1L|GCN1L1|PRIC295
Cytomap('ABCC5')('GCN1L1')

3q27.1

12q24.23

Type of geneprotein-codingprotein-coding
Descriptionmultidrug resistance-associated protein 5ATP-binding cassette, sub-family C (CFTR/MRP), member 5canalicular multispecific organic anion transporter Cmulti-specific organic anion transporter CeIF-2-alpha kinase activator GCN1GCN1 (general control of amino-acid synthesis 1, yeast)-like 1GCN1 eIF-2-alpha kinase activator homologGCN1 general control of amino-acid synthesis 1-like 1GCN1, eIF2 alpha kinase activator homologGCN1-like protein 1
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000334444, ENST00000382494, 
ENST00000392579, ENST00000265586, 
ENST00000427120, ENST00000446941, 
ENST00000492216, 
Fusion gene scores* DoF score16 X 12 X 9=17283 X 3 X 2=18
# samples 153
** MAII scorelog2(15/1728*10)=-3.52606881166759
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: ABCC5 [Title/Abstract] AND GCN1L1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointABCC5(183705558)-GCN1L1(120599862), # samples:1
Anticipated loss of major functional domain due to fusion event.ABCC5-GCN1L1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ABCC5-GCN1L1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ABCC5-GCN1L1 seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
ABCC5-GCN1L1 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneABCC5

GO:0042908

xenobiotic transport

10840050

HgeneABCC5

GO:0140115

export across plasma membrane

10840050


check buttonFusion gene breakpoints across ABCC5 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across GCN1L1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-BR-8284-01AABCC5chr3

183705558

-GCN1L1chr12

120599862

-


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Fusion Gene ORF analysis for ABCC5-GCN1L1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000334444ENST00000300648ABCC5chr3

183705558

-GCN1L1chr12

120599862

-
Frame-shiftENST00000382494ENST00000300648ABCC5chr3

183705558

-GCN1L1chr12

120599862

-
Frame-shiftENST00000392579ENST00000300648ABCC5chr3

183705558

-GCN1L1chr12

120599862

-
In-frameENST00000265586ENST00000300648ABCC5chr3

183705558

-GCN1L1chr12

120599862

-
intron-3CDSENST00000427120ENST00000300648ABCC5chr3

183705558

-GCN1L1chr12

120599862

-
intron-3CDSENST00000446941ENST00000300648ABCC5chr3

183705558

-GCN1L1chr12

120599862

-
intron-3CDSENST00000492216ENST00000300648ABCC5chr3

183705558

-GCN1L1chr12

120599862

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000265586ABCC5chr3183705558-ENST00000300648GCN1L1chr12120599862-71026031264552147

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000265586ENST00000300648ABCC5chr3183705558-GCN1L1chr12120599862-0.0054541850.9945458

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Fusion Genomic Features for ABCC5-GCN1L1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

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Fusion Protein Features for ABCC5-GCN1L1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr3:183705558/chr12:120599862)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneABCC5chr3:183705558chr12:120599862ENST00000334444-530179_1991971438.0TransmembraneHelical
HgeneABCC5chr3:183705558chr12:120599862ENST00000382494-57179_199197533.3333333333334TransmembraneHelical
HgeneABCC5chr3:183705558chr12:120599862ENST00000392579-56179_199197226.0TransmembraneHelical
TgeneGCN1L1chr3:183705558chr12:120599862ENST000003006481958804_8637212672.0Coiled coilOntology_term=ECO:0000255
TgeneGCN1L1chr3:183705558chr12:120599862ENST0000030064819581035_10727212672.0RepeatHEAT 13
TgeneGCN1L1chr3:183705558chr12:120599862ENST0000030064819581078_11157212672.0RepeatHEAT 14
TgeneGCN1L1chr3:183705558chr12:120599862ENST0000030064819581155_11927212672.0RepeatHEAT 15
TgeneGCN1L1chr3:183705558chr12:120599862ENST0000030064819581210_12507212672.0RepeatHEAT 16
TgeneGCN1L1chr3:183705558chr12:120599862ENST0000030064819581251_12897212672.0RepeatHEAT 17
TgeneGCN1L1chr3:183705558chr12:120599862ENST0000030064819581290_13327212672.0RepeatHEAT 18
TgeneGCN1L1chr3:183705558chr12:120599862ENST0000030064819581335_13727212672.0RepeatHEAT 19
TgeneGCN1L1chr3:183705558chr12:120599862ENST0000030064819581374_14107212672.0RepeatHEAT 20
TgeneGCN1L1chr3:183705558chr12:120599862ENST0000030064819581413_14517212672.0RepeatHEAT 21
TgeneGCN1L1chr3:183705558chr12:120599862ENST0000030064819581455_14927212672.0RepeatHEAT 22
TgeneGCN1L1chr3:183705558chr12:120599862ENST0000030064819581493_15307212672.0RepeatHEAT 23
TgeneGCN1L1chr3:183705558chr12:120599862ENST0000030064819581534_15717212672.0RepeatHEAT 24
TgeneGCN1L1chr3:183705558chr12:120599862ENST0000030064819581573_16097212672.0RepeatHEAT 25
TgeneGCN1L1chr3:183705558chr12:120599862ENST0000030064819581611_16487212672.0RepeatHEAT 26
TgeneGCN1L1chr3:183705558chr12:120599862ENST0000030064819581653_16907212672.0RepeatHEAT 27
TgeneGCN1L1chr3:183705558chr12:120599862ENST0000030064819581692_17297212672.0RepeatHEAT 28
TgeneGCN1L1chr3:183705558chr12:120599862ENST0000030064819581731_17697212672.0RepeatHEAT 29
TgeneGCN1L1chr3:183705558chr12:120599862ENST0000030064819581773_18107212672.0RepeatHEAT 30
TgeneGCN1L1chr3:183705558chr12:120599862ENST0000030064819581812_18487212672.0RepeatHEAT 31
TgeneGCN1L1chr3:183705558chr12:120599862ENST0000030064819581921_19587212672.0RepeatHEAT 32
TgeneGCN1L1chr3:183705558chr12:120599862ENST0000030064819581959_19967212672.0RepeatHEAT 33
TgeneGCN1L1chr3:183705558chr12:120599862ENST0000030064819582001_20387212672.0RepeatHEAT 34
TgeneGCN1L1chr3:183705558chr12:120599862ENST0000030064819582039_20767212672.0RepeatHEAT 35
TgeneGCN1L1chr3:183705558chr12:120599862ENST0000030064819582078_21067212672.0RepeatHEAT 36
TgeneGCN1L1chr3:183705558chr12:120599862ENST0000030064819582107_21467212672.0RepeatHEAT 37
TgeneGCN1L1chr3:183705558chr12:120599862ENST0000030064819582147_21847212672.0RepeatHEAT 38
TgeneGCN1L1chr3:183705558chr12:120599862ENST0000030064819582188_22257212672.0RepeatHEAT 39
TgeneGCN1L1chr3:183705558chr12:120599862ENST0000030064819582259_22967212672.0RepeatHEAT 40
TgeneGCN1L1chr3:183705558chr12:120599862ENST0000030064819582301_23387212672.0RepeatHEAT 41
TgeneGCN1L1chr3:183705558chr12:120599862ENST0000030064819582339_23807212672.0RepeatHEAT 42
TgeneGCN1L1chr3:183705558chr12:120599862ENST0000030064819582382_24177212672.0RepeatHEAT 43
TgeneGCN1L1chr3:183705558chr12:120599862ENST0000030064819582422_24597212672.0RepeatHEAT 44
TgeneGCN1L1chr3:183705558chr12:120599862ENST0000030064819582546_25837212672.0RepeatHEAT 45
TgeneGCN1L1chr3:183705558chr12:120599862ENST0000030064819582588_26257212672.0RepeatHEAT 46
TgeneGCN1L1chr3:183705558chr12:120599862ENST0000030064819582627_26617212672.0RepeatHEAT 47%3B degenerate
TgeneGCN1L1chr3:183705558chr12:120599862ENST000003006481958733_7707212672.0RepeatHEAT 10
TgeneGCN1L1chr3:183705558chr12:120599862ENST000003006481958879_9257212672.0RepeatHEAT 11
TgeneGCN1L1chr3:183705558chr12:120599862ENST000003006481958979_10167212672.0RepeatHEAT 12

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneABCC5chr3:183705558chr12:120599862ENST00000334444-5301193_14271971438.0DomainABC transporter 2
HgeneABCC5chr3:183705558chr12:120599862ENST00000334444-530179_4591971438.0DomainABC transmembrane type-1 1
HgeneABCC5chr3:183705558chr12:120599862ENST00000334444-530562_7831971438.0DomainABC transporter 1
HgeneABCC5chr3:183705558chr12:120599862ENST00000334444-530859_11551971438.0DomainABC transmembrane type-1 2
HgeneABCC5chr3:183705558chr12:120599862ENST00000382494-571193_1427197533.3333333333334DomainABC transporter 2
HgeneABCC5chr3:183705558chr12:120599862ENST00000382494-57179_459197533.3333333333334DomainABC transmembrane type-1 1
HgeneABCC5chr3:183705558chr12:120599862ENST00000382494-57562_783197533.3333333333334DomainABC transporter 1
HgeneABCC5chr3:183705558chr12:120599862ENST00000382494-57859_1155197533.3333333333334DomainABC transmembrane type-1 2
HgeneABCC5chr3:183705558chr12:120599862ENST00000392579-561193_1427197226.0DomainABC transporter 2
HgeneABCC5chr3:183705558chr12:120599862ENST00000392579-56179_459197226.0DomainABC transmembrane type-1 1
HgeneABCC5chr3:183705558chr12:120599862ENST00000392579-56562_783197226.0DomainABC transporter 1
HgeneABCC5chr3:183705558chr12:120599862ENST00000392579-56859_1155197226.0DomainABC transmembrane type-1 2
HgeneABCC5chr3:183705558chr12:120599862ENST00000334444-5301227_12341971438.0Nucleotide bindingATP 2
HgeneABCC5chr3:183705558chr12:120599862ENST00000334444-530595_6021971438.0Nucleotide bindingATP 1
HgeneABCC5chr3:183705558chr12:120599862ENST00000382494-571227_1234197533.3333333333334Nucleotide bindingATP 2
HgeneABCC5chr3:183705558chr12:120599862ENST00000382494-57595_602197533.3333333333334Nucleotide bindingATP 1
HgeneABCC5chr3:183705558chr12:120599862ENST00000392579-561227_1234197226.0Nucleotide bindingATP 2
HgeneABCC5chr3:183705558chr12:120599862ENST00000392579-56595_602197226.0Nucleotide bindingATP 1
HgeneABCC5chr3:183705558chr12:120599862ENST00000334444-5301018_10381971438.0TransmembraneHelical
HgeneABCC5chr3:183705558chr12:120599862ENST00000334444-5301104_11241971438.0TransmembraneHelical
HgeneABCC5chr3:183705558chr12:120599862ENST00000334444-5301127_11471971438.0TransmembraneHelical
HgeneABCC5chr3:183705558chr12:120599862ENST00000334444-530219_2391971438.0TransmembraneHelical
HgeneABCC5chr3:183705558chr12:120599862ENST00000334444-530296_3161971438.0TransmembraneHelical
HgeneABCC5chr3:183705558chr12:120599862ENST00000334444-530317_3371971438.0TransmembraneHelical
HgeneABCC5chr3:183705558chr12:120599862ENST00000334444-530400_4201971438.0TransmembraneHelical
HgeneABCC5chr3:183705558chr12:120599862ENST00000334444-530434_4541971438.0TransmembraneHelical
HgeneABCC5chr3:183705558chr12:120599862ENST00000334444-530608_6281971438.0TransmembraneHelical
HgeneABCC5chr3:183705558chr12:120599862ENST00000334444-530848_8681971438.0TransmembraneHelical
HgeneABCC5chr3:183705558chr12:120599862ENST00000334444-530917_9371971438.0TransmembraneHelical
HgeneABCC5chr3:183705558chr12:120599862ENST00000334444-530997_10171971438.0TransmembraneHelical
HgeneABCC5chr3:183705558chr12:120599862ENST00000382494-571018_1038197533.3333333333334TransmembraneHelical
HgeneABCC5chr3:183705558chr12:120599862ENST00000382494-571104_1124197533.3333333333334TransmembraneHelical
HgeneABCC5chr3:183705558chr12:120599862ENST00000382494-571127_1147197533.3333333333334TransmembraneHelical
HgeneABCC5chr3:183705558chr12:120599862ENST00000382494-57219_239197533.3333333333334TransmembraneHelical
HgeneABCC5chr3:183705558chr12:120599862ENST00000382494-57296_316197533.3333333333334TransmembraneHelical
HgeneABCC5chr3:183705558chr12:120599862ENST00000382494-57317_337197533.3333333333334TransmembraneHelical
HgeneABCC5chr3:183705558chr12:120599862ENST00000382494-57400_420197533.3333333333334TransmembraneHelical
HgeneABCC5chr3:183705558chr12:120599862ENST00000382494-57434_454197533.3333333333334TransmembraneHelical
HgeneABCC5chr3:183705558chr12:120599862ENST00000382494-57608_628197533.3333333333334TransmembraneHelical
HgeneABCC5chr3:183705558chr12:120599862ENST00000382494-57848_868197533.3333333333334TransmembraneHelical
HgeneABCC5chr3:183705558chr12:120599862ENST00000382494-57917_937197533.3333333333334TransmembraneHelical
HgeneABCC5chr3:183705558chr12:120599862ENST00000382494-57997_1017197533.3333333333334TransmembraneHelical
HgeneABCC5chr3:183705558chr12:120599862ENST00000392579-561018_1038197226.0TransmembraneHelical
HgeneABCC5chr3:183705558chr12:120599862ENST00000392579-561104_1124197226.0TransmembraneHelical
HgeneABCC5chr3:183705558chr12:120599862ENST00000392579-561127_1147197226.0TransmembraneHelical
HgeneABCC5chr3:183705558chr12:120599862ENST00000392579-56219_239197226.0TransmembraneHelical
HgeneABCC5chr3:183705558chr12:120599862ENST00000392579-56296_316197226.0TransmembraneHelical
HgeneABCC5chr3:183705558chr12:120599862ENST00000392579-56317_337197226.0TransmembraneHelical
HgeneABCC5chr3:183705558chr12:120599862ENST00000392579-56400_420197226.0TransmembraneHelical
HgeneABCC5chr3:183705558chr12:120599862ENST00000392579-56434_454197226.0TransmembraneHelical
HgeneABCC5chr3:183705558chr12:120599862ENST00000392579-56608_628197226.0TransmembraneHelical
HgeneABCC5chr3:183705558chr12:120599862ENST00000392579-56848_868197226.0TransmembraneHelical
HgeneABCC5chr3:183705558chr12:120599862ENST00000392579-56917_937197226.0TransmembraneHelical
HgeneABCC5chr3:183705558chr12:120599862ENST00000392579-56997_1017197226.0TransmembraneHelical
TgeneGCN1L1chr3:183705558chr12:120599862ENST000003006481958140_1787212672.0RepeatHEAT 1
TgeneGCN1L1chr3:183705558chr12:120599862ENST000003006481958257_2937212672.0RepeatHEAT 2
TgeneGCN1L1chr3:183705558chr12:120599862ENST000003006481958294_3317212672.0RepeatHEAT 3
TgeneGCN1L1chr3:183705558chr12:120599862ENST000003006481958385_4237212672.0RepeatHEAT 4
TgeneGCN1L1chr3:183705558chr12:120599862ENST000003006481958425_4597212672.0RepeatHEAT 5
TgeneGCN1L1chr3:183705558chr12:120599862ENST000003006481958460_5037212672.0RepeatHEAT 6
TgeneGCN1L1chr3:183705558chr12:120599862ENST000003006481958560_5977212672.0RepeatHEAT 7
TgeneGCN1L1chr3:183705558chr12:120599862ENST000003006481958599_6367212672.0RepeatHEAT 8
TgeneGCN1L1chr3:183705558chr12:120599862ENST000003006481958697_7327212672.0RepeatHEAT 9


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Fusion Gene Sequence for ABCC5-GCN1L1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>299_299_1_ABCC5-GCN1L1_ABCC5_chr3_183705558_ENST00000265586_GCN1L1_chr12_120599862_ENST00000300648_length(transcript)=7102nt_BP=603nt
CACTCAGAGAAGATGAAGGATATCGACATAGGAAAAGAGTATATCATCCCCAGTCCTGGGTATAGAAGTGTGAGGGAGAGAACCAGCACT
TCTGGGACGCACAGAGACCGTGAAGATTCCAAGTTCAGGAGAACTCGACCGTTGGAATGCCAAGATGCCTTGGAAACAGCAGCCCGAGCC
GAGGGCCTCTCTCTTGATGCCTCCATGCATTCTCAGCTCAGAATCCTGGATGAGGAGCATCCCAAGGGAAAGTACCATCATGGCTTGAGT
GCTCTGAAGCCCATCCGGACTACTTCCAAACACCAGCACCCAGTGGACAATGCTGGGCTTTTTTCCTGTATGACTTTTTCGTGGCTTTCT
TCTCTGGCCCGTGTGGCCCACAAGAAGGGGGAGCTCTCAATGGAAGACGTGTGGTCTCTGTCCAAGCACGAGTCTTCTGACGTGAACTGC
AGAAGACTAGAGAGACTGTGGCAAGAAGAGCTGAATGAAGTTGGGCCAGACGCTGCTTCCCTGCGAAGGGTTGTGTGGATCTTCTGCCGC
ACCAGGCTCATCCTGTCCATCGTGTGCCTGATGATCACGCAGCTGGCTGGCTTCAGTGGACCATCCTCCATGAATGCCATGGGCTCCCTT
TCCGTCCTGTCGCCGGACCGGGTCCTCCCACAGCTCATCAGCACCATCACTGCCTCCGTGCAGAACCCTGCACTGCGCCTGGTGACGCGG
GAGGAGTTTGCCATTATGCAGACCCCTGCTGGGGAGCTGTATGACAAATCCATCATTCAGAGTGCCCAGCAGGACAGCATAAAAAAGGCC
AACATGAAGCGAGAGAACAAAGCTTATTCCTTCAAAGAGCAGATCATCGAGCTGGAGCTGAAGGAGGAGATAAAGAAGAAGAAAGGCATC
AAAGAGGAGGTGCAGCTGACCAGCAAGCAGAAGGAGATGCTGCAGGCCCAGCTAGACAGGGAGGCGCAGGTCCGGAGGCGGCTGCAGGAG
CTGGATGGGGAGCTGGAGGCGGCGCTTGGACTGCTGGACATCATCCTGGCCAAGAACCCGTCCGGCCTGACCCAGTACATCCCTGTTTTG
GTCGACTCTTTTCTGCCCTTGCTGAAGTCTCCCCTGGCTGCTCCCAGGATCAAGAACCCCTTCTTGTCCTTGGCTGCCTGTGTCATGCCC
TCTAGGCTCAAGGCTTTGGGCACTTTGGTGAGCCACGTGACCCTGCGCCTGCTGAAGCCAGAGTGTGTCCTGGATAAGTCCTGGTGCCAG
GAAGAGCTGTCGGTGGCTGTGAAGAGGGCGGTGATGCTGCTGCACACCCACACCATCACCAGCAGGGTGGGCAAGGGGGAGCCAGGTGCT
GCGCCCTTGTCCGCGCCAGCCTTCTCCTTAGTCTTCCCGTTTCTGAAGATGGTGCTGACGGAGATGCCCCACCACAGTGAGGAGGAGGAG
GAGTGGATGGCCCAGATTCTTCAGATCCTCACTGTCCAAGCCCAGCTGAGGGCCTCCCCCAACACCCCACCCGGGCGGGTGGACGAGAAT
GGCCCGGAGTTGCTGCCTCGCGTGGCCATGCTGCGTCTTCTGACTTGGGTGATCGGGACGGGCTCGCCTCGCTTACAGGTTCTGGCTTCA
GACACCCTGACCACCCTGTGTGCCAGCAGCAGTGGTGATGATGGCTGTGCCTTTGCAGAGCAGGAGGAGGTGGACGTGCTGCTCTGTGCC
TTGCAGTCCCCGTGTGCCAGCGTGCGGGAAACCGTGCTCCGGGGGCTGATGGAACTCCACATGGTATTGCCAGCACCTGATACTGATGAG
AAGAATGGCCTGAACCTTCTGCGGAGACTCTGGGTGGTCAAGTTTGACAAGGAGGAGGAGATCCGGAAGCTGGCTGAGAGGCTCTGGTCA
ATGATGGGCCTAGACCTGCAGCCAGACCTCTGCTCCTTGCTGATTGACGACGTGATCTATCATGAGGCGGCTGTAAGGCAGGCAGGGGCC
GAAGCCCTCTCCCAAGCAGTGGCACGTTACCAGCGGCAGGCGGCGGAGGTTATGGGCAGGCTCATGGAGATTTACCAGGAAAAGCTCTAC
CGGCCGCCCCCAGTGCTGGATGCTTTGGGACGAGTTATTTCAGAATCTCCTCCAGATCAGTGGGAAGCCAGGTGTGGCTTGGCGTTGGCC
CTCAACAAGCTCTCCCAGTATTTGGACAGCTCTCAGGTGAAGCCACTCTTTCAGTTTTTTGTCCCTGATGCCCTCAATGACCGACACCCA
GATGTCCGGAAGTGCATGTTGGATGCAGCCCTCGCAACGCTCAACACTCATGGGAAGGAGAACGTCAACTCGCTGTTGCCAGTATTCGAG
GAGTTCCTGAAGAACGCGCCCAATGATGCCAGCTATGATGCTGTGCGACAGAGTGTGGTGGTCCTGATGGGCTCTCTGGCCAAGCACCTG
GACAAGAGTGACCCCAAAGTGAAGCCCATTGTTGCCAAGCTCATCGCTGCCCTCTCCACCCCCTCCCAGCAGGTCCAGGAGTCCGTAGCC
AGCTGCTTGCCACCCCTTGTGCCAGCCATCAAGGAGGATGCTGGAGGGATGATCCAGAGGCTTATGCAGCAGCTGCTGGAGTCAGACAAG
TACGCAGAGCGCAAAGGGGCCGCCTATGGCCTGGCGGGCCTGGTGAAGGGCCTGGGCATCCTCTCGCTGAAGCAACAGGAGATGATGGCG
GCACTGACTGATGCCATCCAAGATAAGAAGAACTTCCGCCGGCGAGAGGGAGCCCTCTTTGCCTTCGAGATGCTCTGCACCATGCTGGGG
AAACTTTTTGAGCCGTATGTGGTTCACGTGCTGCCCCATCTGCTCCTGTGCTTTGGGGATGGAAACCAGTATGTGCGTGAGGCTGCAGAT
GACTGTGCCAAGGCTGTGATGAGCAACTTGAGTGCTCACGGGGTGAAGCTGGTGCTCCCCTCCTTACTGGCTGCCCTGGAGGAGGAATCG
TGGCGGACCAAAGCTGGGTCAGTGGAGCTTCTTGGGGCAATGGCGTACTGTGCTCCTAAGCAGCTGTCATCCTGTCTACCCAACATTGTG
CCCAAGCTTACGGAGGTGCTGACCGACTCCCATGTCAAAGTCCAGAAGGCTGGACAGCAGGCGCTCAGGCAGATCGGCTCCGTTATCAGG
AACCCGGAGATCCTGGCCATTGCTCCAGTCCTCCTGGATGCCCTGACGGATCCCTCCAGGAAGACCCAGAAGTGCTTGCAGACCCTGCTG
GACACCAAGTTTGTCCACTTCATTGATGCCCCATCCCTGGCCCTCATCATGCCCATTGTCCAGAGAGCCTTCCAGGACCGTTCCACGGAC
ACGCGGAAGATGGCAGCCCAGATTATTGGCAACATGTACTCCCTGACAGACCAGAAGGACTTGGCTCCGTACCTGCCCAGCGTGACGCCT
GGCCTGAAAGCATCGCTTTTGGACCCTGTGCCTGAGGTGCGGACCGTATCTGCAAAGGCCCTTGGGGCCATGGTGAAGGGCATGGGGGAG
TCGTGCTTTGAGGACTTGCTGCCGTGGCTGATGGAGACACTGACCTATGAGCAGAGCTCTGTGGATCGCTCAGGCGCTGCACAGGGGTTG
GCTGAGGTCATGGCCGGTTTGGGGGTGGAGAAGTTGGAGAAGTTGATGCCAGAAATCGTGGCTACAGCCAGCAAAGTGGACATTGCACCC
CATGTCCGAGATGGCTACATTATGATGTTTAACTACCTGCCCATCACCTTTGGAGACAAGTTTACTCCTTATGTGGGGCCCATCATCCCC
TGTATCCTCAAAGCTCTTGCTGATGAGAATGAGTTTGTGCGTGACACCGCCCTGCGCGCGGGCCAGCGGGTTATCTCCATGTACGCTGAG
ACAGCCATCGCCCTGCTGCTGCCCCAGCTAGAGCAAGGCCTCTTTGATGACCTTTGGAGAATCAGGTTCAGCTCTGTTCAGCTCCTTGGG
GATCTCCTGTTTCACATCTCAGGAGTCACTGGGAAGATGACCACAGAAACTGCCTCTGAGGATGATAACTTTGGAACTGCCCAGTCCAAC
AAGGCGATCATCACTGCCCTGGGGGTAGAGCGGCGGAACCGGGTGTTGGCAGGGCTGTACATGGGCCGCTCAGACACCCAGCTGGTGGTG
CGGCAGGCGTCCCTGCATGTCTGGAAGATTGTTGTCTCCAATACCCCCCGCACCTTGCGTGAGATCCTACCCACTCTCTTTGGGCTCCTG
CTGGGTTTCCTGGCCAGCACGTGTGCAGATAAGAGAACGATTGCAGCGAGAACATTGGGAGATCTTGTGCGGAAGTTAGGGGAGAAAATC
CTCCCCGAGATCATCCCCATCCTTGAGGAAGGCCTGAGGTCTCAGAAGAGCGATGAGAGGCAGGGTGTGTGCATTGGCCTAAGTGAGATC
ATGAAGTCCACCAGCCGGGATGCCGTGCTGTATTTCTCTGAATCCCTCGTGCCCACGGCAAGGAAGGCTTTGTGTGACCCACTGGAGGAG
GTCAGAGAGGCGGCAGCCAAGACTTTCGAGCAGCTGCATTCCACCATCGGCCACCAGGCTCTGGAGGACATTCTCCCATTTTTACTAAAG
CAGCTGGATGACGAGGAGGTGTCAGAGTTTGCCTTGGATGGTCTGAAGCAAGTCATGGCTATTAAGAGTCGTGTGGTGCTGCCCTACCTT
GTGCCCAAGCTGACAACGCCACCTGTCAACACCCGGGTGCTGGCTTTCCTTTCGTCAGTGGCTGGTGATGCCCTCACCCGTCATCTTGGC
GTGATCCTCCCAGCGGTCATGCTGGCCCTGAAGGAAAAGCTTGGGACCCCAGATGAGCAGCTGGAGATGGCCAATTGTCAGGCTGTGATC
CTCTCCGTAGAGGATGACACAGGGCACCGGATCATCATCGAGTATCTGCTGGAGGCCACCCGCAGCCCTGAGGTGGGCATGAGGCAAGCT
GCTGCCATCATCCTCAACATCTACTGTTCCCGCTCAAAGGCTGACTACACCAGCCACCTGCGGAGCCTGGTCTCGGGCCTGATCCGCCTC
TTCAATGACTCCAGCCCTGTGGTTCTGGAGGAGAGCTGGGATGCCCTAAATGCCATCACTAAGAAGCTGGATGCTGGCAACCAGTTGGCA
CTCATTGAAGAGCTGCACAAGGAAATCCGGCTCATAGGGAACGAGAGCAAAGGCGAGCATGTGCCAGGATTCTGCCTCCCGAAGAAGGGA
GTGACCTCCATCCTTCCAGTGTTGCGGGAAGGAGTCCTGACTGGCAGCCCTGAGCAGAAGGAGGAGGCAGCCAAAGCCTTAGGCTTGGTA
ATCCGCCTGACCTCGGCTGACGCCCTGAGGCCCTCCGTGGTCAGCATCACTGGCCCTCTGATCCGCATCCTGGGGGACAGGTTCAGCTGG
AATGTGAAGGCGGCTCTGCTCGAGACACTCAGCCTCTTGTTGGCTAAGGTTGGGATTGCCCTGAAGCCCTTCCTGCCCCAGCTGCAGACC
ACTTTCACCAAAGCCCTGCAGGACTCCAACCGGGGGGTGCGCCTGAAGGCCGCAGATGCTCTGGGGAAGCTCATTTCCATCCACATTAAG
GTGGACCCCCTCTTCACAGAGCTGCTCAATGGCATCCGCGCCATGGAGGACCCAGGTGTCAGGGACACCATGCTGCAGGCCCTGAGGTTT
GTGATTCAGGGAGCAGGGGCCAAAGTGGATGCCGTCATCCGGAAAAACATCGTCTCACTCCTGCTGAGCATGCTGGGACACGATGAGGAC
AACACTCGCATCTCCTCAGCCGGGTGCCTAGGGGAACTGTGTGCCTTTTTGACTGAAGAGGAGCTTAGTGCCGTTCTACAGCAGTGCTTG
CTGGCGGACGTGTCCGGCATTGACTGGATGGTTCGGCACGGGCGGAGCCTGGCACTTTCCGTGGCTGTGAATGTGGCTCCTGGCAGACTT
TGTGCCGGCAGATATAGCAGTGATGTTCAGGAAATGATCCTGAGCAGTGCCACGGCGGACAGGATCCCCATTGCGGTGAGCGGGGTCCGG
GGCATGGGCTTTCTCATGAGACACCACATCGAGACAGGCGGAGGGCAGTTGCCGGCCAAACTTTCCAGCCTGTTCGTTAAGTGTCTGCAG
AACCCATCCAGCGACATCAGGCTGGTGGCTGAGAAGATGATCTGGTGGGCAAATAAGGACCCACTGCCTCCCCTGGACCCCCAGGCCATC
AAGCCCATCCTGAAGGCTCTTCTTGACAACACCAAGGATAAGAACACCGTGGTCAGGGCCTACAGCGACCAGGCAATTGTCAACCTCCTC
AAGATGCGGCAGGGTGAAGAGGTGTTTCAGTCCCTCTCCAAGATCCTGGATGTGGCCAGTTTGGAGGTGCTGAACGAGGTTAACCGAAGG
TCCCTGAAGAAGCTGGCCAGCCAGGCCGACTCCACGGAGCAGGTGGACGACACCATCCTGACATGAGAGGCCTGGGCCAGCAGCAGCATT
GCCGCTCCACATCTTTGCTCAATGTTTTCATTTTTGAAAATACATTTGTTCCAATGGGGAGCTTGGAAGATGGCGTTCCCAGAAAGTATT
TTAATATCAATAGACCACAGCCAAAGCCTTAAATCAAACCCACACACAACTGAAAATTGCCTCCTCCATCTCTCACCTTTTCCTGTGGAG
AAGAGAAGGAAAAGCACACGCATGCGCCTCAGCAAATGGCAGCCCAGGAGCTGTTTGTCCAGTTTAGCATGGCTAGGTCTGGAACTATAA
TAGCAGGGTCAGACTGTGGGTTCCTCTTCTCCTGTGCTTGAGCTCTGGTTTGAGAGCTGGCGCTACCAACCTTTTTCCTATATCCCGAGT
GGGGCACAGACGGTGGATCTCTGCCCAGTGTGGTGTGTCTGGCTTGGCTTTTCAATATTGTGAGGTCTGAATGGATCTGACCCCTGTCAG
ATGAAAATGATTCACAGCTCTGGCAGTTCCCAAGTCTGGGGAGGGGTATAGGTTTGAAAGGCTGTTTGAAAGAGGAATGTTTAATAAAGG

>299_299_1_ABCC5-GCN1L1_ABCC5_chr3_183705558_ENST00000265586_GCN1L1_chr12_120599862_ENST00000300648_length(amino acids)=2147AA_BP=197
MKDIDIGKEYIIPSPGYRSVRERTSTSGTHRDREDSKFRRTRPLECQDALETAARAEGLSLDASMHSQLRILDEEHPKGKYHHGLSALKP
IRTTSKHQHPVDNAGLFSCMTFSWLSSLARVAHKKGELSMEDVWSLSKHESSDVNCRRLERLWQEELNEVGPDAASLRRVVWIFCRTRLI
LSIVCLMITQLAGFSGPSSMNAMGSLSVLSPDRVLPQLISTITASVQNPALRLVTREEFAIMQTPAGELYDKSIIQSAQQDSIKKANMKR
ENKAYSFKEQIIELELKEEIKKKKGIKEEVQLTSKQKEMLQAQLDREAQVRRRLQELDGELEAALGLLDIILAKNPSGLTQYIPVLVDSF
LPLLKSPLAAPRIKNPFLSLAACVMPSRLKALGTLVSHVTLRLLKPECVLDKSWCQEELSVAVKRAVMLLHTHTITSRVGKGEPGAAPLS
APAFSLVFPFLKMVLTEMPHHSEEEEEWMAQILQILTVQAQLRASPNTPPGRVDENGPELLPRVAMLRLLTWVIGTGSPRLQVLASDTLT
TLCASSSGDDGCAFAEQEEVDVLLCALQSPCASVRETVLRGLMELHMVLPAPDTDEKNGLNLLRRLWVVKFDKEEEIRKLAERLWSMMGL
DLQPDLCSLLIDDVIYHEAAVRQAGAEALSQAVARYQRQAAEVMGRLMEIYQEKLYRPPPVLDALGRVISESPPDQWEARCGLALALNKL
SQYLDSSQVKPLFQFFVPDALNDRHPDVRKCMLDAALATLNTHGKENVNSLLPVFEEFLKNAPNDASYDAVRQSVVVLMGSLAKHLDKSD
PKVKPIVAKLIAALSTPSQQVQESVASCLPPLVPAIKEDAGGMIQRLMQQLLESDKYAERKGAAYGLAGLVKGLGILSLKQQEMMAALTD
AIQDKKNFRRREGALFAFEMLCTMLGKLFEPYVVHVLPHLLLCFGDGNQYVREAADDCAKAVMSNLSAHGVKLVLPSLLAALEEESWRTK
AGSVELLGAMAYCAPKQLSSCLPNIVPKLTEVLTDSHVKVQKAGQQALRQIGSVIRNPEILAIAPVLLDALTDPSRKTQKCLQTLLDTKF
VHFIDAPSLALIMPIVQRAFQDRSTDTRKMAAQIIGNMYSLTDQKDLAPYLPSVTPGLKASLLDPVPEVRTVSAKALGAMVKGMGESCFE
DLLPWLMETLTYEQSSVDRSGAAQGLAEVMAGLGVEKLEKLMPEIVATASKVDIAPHVRDGYIMMFNYLPITFGDKFTPYVGPIIPCILK
ALADENEFVRDTALRAGQRVISMYAETAIALLLPQLEQGLFDDLWRIRFSSVQLLGDLLFHISGVTGKMTTETASEDDNFGTAQSNKAII
TALGVERRNRVLAGLYMGRSDTQLVVRQASLHVWKIVVSNTPRTLREILPTLFGLLLGFLASTCADKRTIAARTLGDLVRKLGEKILPEI
IPILEEGLRSQKSDERQGVCIGLSEIMKSTSRDAVLYFSESLVPTARKALCDPLEEVREAAAKTFEQLHSTIGHQALEDILPFLLKQLDD
EEVSEFALDGLKQVMAIKSRVVLPYLVPKLTTPPVNTRVLAFLSSVAGDALTRHLGVILPAVMLALKEKLGTPDEQLEMANCQAVILSVE
DDTGHRIIIEYLLEATRSPEVGMRQAAAIILNIYCSRSKADYTSHLRSLVSGLIRLFNDSSPVVLEESWDALNAITKKLDAGNQLALIEE
LHKEIRLIGNESKGEHVPGFCLPKKGVTSILPVLREGVLTGSPEQKEEAAKALGLVIRLTSADALRPSVVSITGPLIRILGDRFSWNVKA
ALLETLSLLLAKVGIALKPFLPQLQTTFTKALQDSNRGVRLKAADALGKLISIHIKVDPLFTELLNGIRAMEDPGVRDTMLQALRFVIQG
AGAKVDAVIRKNIVSLLLSMLGHDEDNTRISSAGCLGELCAFLTEEELSAVLQQCLLADVSGIDWMVRHGRSLALSVAVNVAPGRLCAGR
YSSDVQEMILSSATADRIPIAVSGVRGMGFLMRHHIETGGGQLPAKLSSLFVKCLQNPSSDIRLVAEKMIWWANKDPLPPLDPQAIKPIL

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Fusion Gene PPI Analysis for ABCC5-GCN1L1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ABCC5-GCN1L1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ABCC5-GCN1L1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneABCC5C0003873Rheumatoid Arthritis1CTD_human
HgeneABCC5C0009402Colorectal Carcinoma1CTD_human
HgeneABCC5C0009404Colorectal Neoplasms1CTD_human
HgeneABCC5C0023893Liver Cirrhosis, Experimental1CTD_human