Fusion Gene Studies
in Kim Lab

FusionBase FusionGDB FusionGDB2 FusionPDB FusionNeoAntigen FusionAI FusionNW FGviewer Publication Contact
FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:ABCC9-DMKN (FusionGDB2 ID:HG10060TG93099)

Fusion Gene Summary for ABCC9-DMKN

check button Fusion gene summary
Fusion gene informationFusion gene name: ABCC9-DMKN
Fusion gene ID: hg10060tg93099
HgeneTgene
Gene symbol

ABCC9

DMKN

Gene ID

10060

93099

Gene nameATP binding cassette subfamily C member 9dermokine
SynonymsABC37|ATFB12|CANTU|CMD1O|SUR2UNQ729|ZD52F10
Cytomap('ABCC9')('DMKN')

12p12.1

19q13.12

Type of geneprotein-codingprotein-coding
DescriptionATP-binding cassette sub-family C member 9ATP-binding cassette transporter sub-family C member 9ATP-binding cassette, sub-family C (CFTR/MRP), member 9sulfonylurea receptor 2dermokineepidermis-specific secreted protein SK30/SK89
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000261200, ENST00000261201, 
ENST00000345162, ENST00000326684, 
ENST00000538350, 
Fusion gene scores* DoF score3 X 4 X 3=367 X 9 X 6=378
# samples 49
** MAII scorelog2(4/36*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(9/378*10)=-2.0703893278914
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ABCC9 [Title/Abstract] AND DMKN [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointABCC9(22028588)-DMKN(35996888), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID


check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4OVTCGA-25-1870-01AABCC9chr12

22028588

-DMKNchr19

35996888

-
ChimerDB4OVTCGA-25-1870ABCC9chr12

22028587

-DMKNchr19

35996888

-


Top

Fusion Gene ORF analysis for ABCC9-DMKN

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000261200ENST00000392206ABCC9chr12

22028588

-DMKNchr19

35996888

-
5CDS-5UTRENST00000261200ENST00000392206ABCC9chr12

22028587

-DMKNchr19

35996888

-
5CDS-5UTRENST00000261200ENST00000418261ABCC9chr12

22028588

-DMKNchr19

35996888

-
5CDS-5UTRENST00000261200ENST00000418261ABCC9chr12

22028587

-DMKNchr19

35996888

-
5CDS-5UTRENST00000261200ENST00000424570ABCC9chr12

22028588

-DMKNchr19

35996888

-
5CDS-5UTRENST00000261200ENST00000424570ABCC9chr12

22028587

-DMKNchr19

35996888

-
5CDS-5UTRENST00000261200ENST00000440396ABCC9chr12

22028588

-DMKNchr19

35996888

-
5CDS-5UTRENST00000261200ENST00000440396ABCC9chr12

22028587

-DMKNchr19

35996888

-
5CDS-5UTRENST00000261200ENST00000443640ABCC9chr12

22028588

-DMKNchr19

35996888

-
5CDS-5UTRENST00000261200ENST00000443640ABCC9chr12

22028587

-DMKNchr19

35996888

-
5CDS-5UTRENST00000261200ENST00000447113ABCC9chr12

22028588

-DMKNchr19

35996888

-
5CDS-5UTRENST00000261200ENST00000447113ABCC9chr12

22028587

-DMKNchr19

35996888

-
5CDS-5UTRENST00000261200ENST00000451297ABCC9chr12

22028588

-DMKNchr19

35996888

-
5CDS-5UTRENST00000261200ENST00000451297ABCC9chr12

22028587

-DMKNchr19

35996888

-
5CDS-5UTRENST00000261200ENST00000458071ABCC9chr12

22028588

-DMKNchr19

35996888

-
5CDS-5UTRENST00000261200ENST00000458071ABCC9chr12

22028587

-DMKNchr19

35996888

-
5CDS-5UTRENST00000261200ENST00000461300ABCC9chr12

22028588

-DMKNchr19

35996888

-
5CDS-5UTRENST00000261200ENST00000461300ABCC9chr12

22028587

-DMKNchr19

35996888

-
5CDS-5UTRENST00000261200ENST00000462126ABCC9chr12

22028588

-DMKNchr19

35996888

-
5CDS-5UTRENST00000261200ENST00000462126ABCC9chr12

22028587

-DMKNchr19

35996888

-
5CDS-5UTRENST00000261200ENST00000472252ABCC9chr12

22028588

-DMKNchr19

35996888

-
5CDS-5UTRENST00000261200ENST00000472252ABCC9chr12

22028587

-DMKNchr19

35996888

-
5CDS-5UTRENST00000261200ENST00000474928ABCC9chr12

22028588

-DMKNchr19

35996888

-
5CDS-5UTRENST00000261200ENST00000474928ABCC9chr12

22028587

-DMKNchr19

35996888

-
5CDS-5UTRENST00000261200ENST00000488892ABCC9chr12

22028588

-DMKNchr19

35996888

-
5CDS-5UTRENST00000261200ENST00000488892ABCC9chr12

22028587

-DMKNchr19

35996888

-
5CDS-5UTRENST00000261200ENST00000492341ABCC9chr12

22028588

-DMKNchr19

35996888

-
5CDS-5UTRENST00000261200ENST00000492341ABCC9chr12

22028587

-DMKNchr19

35996888

-
5CDS-5UTRENST00000261200ENST00000602781ABCC9chr12

22028588

-DMKNchr19

35996888

-
5CDS-5UTRENST00000261200ENST00000602781ABCC9chr12

22028587

-DMKNchr19

35996888

-
5CDS-5UTRENST00000261201ENST00000392206ABCC9chr12

22028588

-DMKNchr19

35996888

-
5CDS-5UTRENST00000261201ENST00000392206ABCC9chr12

22028587

-DMKNchr19

35996888

-
5CDS-5UTRENST00000261201ENST00000418261ABCC9chr12

22028588

-DMKNchr19

35996888

-
5CDS-5UTRENST00000261201ENST00000418261ABCC9chr12

22028587

-DMKNchr19

35996888

-
5CDS-5UTRENST00000261201ENST00000424570ABCC9chr12

22028588

-DMKNchr19

35996888

-
5CDS-5UTRENST00000261201ENST00000424570ABCC9chr12

22028587

-DMKNchr19

35996888

-
5CDS-5UTRENST00000261201ENST00000440396ABCC9chr12

22028588

-DMKNchr19

35996888

-
5CDS-5UTRENST00000261201ENST00000440396ABCC9chr12

22028587

-DMKNchr19

35996888

-
5CDS-5UTRENST00000261201ENST00000443640ABCC9chr12

22028588

-DMKNchr19

35996888

-
5CDS-5UTRENST00000261201ENST00000443640ABCC9chr12

22028587

-DMKNchr19

35996888

-
5CDS-5UTRENST00000261201ENST00000447113ABCC9chr12

22028588

-DMKNchr19

35996888

-
5CDS-5UTRENST00000261201ENST00000447113ABCC9chr12

22028587

-DMKNchr19

35996888

-
5CDS-5UTRENST00000261201ENST00000451297ABCC9chr12

22028588

-DMKNchr19

35996888

-
5CDS-5UTRENST00000261201ENST00000451297ABCC9chr12

22028587

-DMKNchr19

35996888

-
5CDS-5UTRENST00000261201ENST00000458071ABCC9chr12

22028588

-DMKNchr19

35996888

-
5CDS-5UTRENST00000261201ENST00000458071ABCC9chr12

22028587

-DMKNchr19

35996888

-
5CDS-5UTRENST00000261201ENST00000461300ABCC9chr12

22028588

-DMKNchr19

35996888

-
5CDS-5UTRENST00000261201ENST00000461300ABCC9chr12

22028587

-DMKNchr19

35996888

-
5CDS-5UTRENST00000261201ENST00000462126ABCC9chr12

22028588

-DMKNchr19

35996888

-
5CDS-5UTRENST00000261201ENST00000462126ABCC9chr12

22028587

-DMKNchr19

35996888

-
5CDS-5UTRENST00000261201ENST00000472252ABCC9chr12

22028588

-DMKNchr19

35996888

-
5CDS-5UTRENST00000261201ENST00000472252ABCC9chr12

22028587

-DMKNchr19

35996888

-
5CDS-5UTRENST00000261201ENST00000474928ABCC9chr12

22028588

-DMKNchr19

35996888

-
5CDS-5UTRENST00000261201ENST00000474928ABCC9chr12

22028587

-DMKNchr19

35996888

-
5CDS-5UTRENST00000261201ENST00000488892ABCC9chr12

22028588

-DMKNchr19

35996888

-
5CDS-5UTRENST00000261201ENST00000488892ABCC9chr12

22028587

-DMKNchr19

35996888

-
5CDS-5UTRENST00000261201ENST00000492341ABCC9chr12

22028588

-DMKNchr19

35996888

-
5CDS-5UTRENST00000261201ENST00000492341ABCC9chr12

22028587

-DMKNchr19

35996888

-
5CDS-5UTRENST00000261201ENST00000602781ABCC9chr12

22028588

-DMKNchr19

35996888

-
5CDS-5UTRENST00000261201ENST00000602781ABCC9chr12

22028587

-DMKNchr19

35996888

-
5CDS-5UTRENST00000345162ENST00000392206ABCC9chr12

22028588

-DMKNchr19

35996888

-
5CDS-5UTRENST00000345162ENST00000392206ABCC9chr12

22028587

-DMKNchr19

35996888

-
5CDS-5UTRENST00000345162ENST00000418261ABCC9chr12

22028588

-DMKNchr19

35996888

-
5CDS-5UTRENST00000345162ENST00000418261ABCC9chr12

22028587

-DMKNchr19

35996888

-
5CDS-5UTRENST00000345162ENST00000424570ABCC9chr12

22028588

-DMKNchr19

35996888

-
5CDS-5UTRENST00000345162ENST00000424570ABCC9chr12

22028587

-DMKNchr19

35996888

-
5CDS-5UTRENST00000345162ENST00000440396ABCC9chr12

22028588

-DMKNchr19

35996888

-
5CDS-5UTRENST00000345162ENST00000440396ABCC9chr12

22028587

-DMKNchr19

35996888

-
5CDS-5UTRENST00000345162ENST00000443640ABCC9chr12

22028588

-DMKNchr19

35996888

-
5CDS-5UTRENST00000345162ENST00000443640ABCC9chr12

22028587

-DMKNchr19

35996888

-
5CDS-5UTRENST00000345162ENST00000447113ABCC9chr12

22028588

-DMKNchr19

35996888

-
5CDS-5UTRENST00000345162ENST00000447113ABCC9chr12

22028587

-DMKNchr19

35996888

-
5CDS-5UTRENST00000345162ENST00000451297ABCC9chr12

22028588

-DMKNchr19

35996888

-
5CDS-5UTRENST00000345162ENST00000451297ABCC9chr12

22028587

-DMKNchr19

35996888

-
5CDS-5UTRENST00000345162ENST00000458071ABCC9chr12

22028588

-DMKNchr19

35996888

-
5CDS-5UTRENST00000345162ENST00000458071ABCC9chr12

22028587

-DMKNchr19

35996888

-
5CDS-5UTRENST00000345162ENST00000461300ABCC9chr12

22028588

-DMKNchr19

35996888

-
5CDS-5UTRENST00000345162ENST00000461300ABCC9chr12

22028587

-DMKNchr19

35996888

-
5CDS-5UTRENST00000345162ENST00000462126ABCC9chr12

22028588

-DMKNchr19

35996888

-
5CDS-5UTRENST00000345162ENST00000462126ABCC9chr12

22028587

-DMKNchr19

35996888

-
5CDS-5UTRENST00000345162ENST00000472252ABCC9chr12

22028588

-DMKNchr19

35996888

-
5CDS-5UTRENST00000345162ENST00000472252ABCC9chr12

22028587

-DMKNchr19

35996888

-
5CDS-5UTRENST00000345162ENST00000474928ABCC9chr12

22028588

-DMKNchr19

35996888

-
5CDS-5UTRENST00000345162ENST00000474928ABCC9chr12

22028587

-DMKNchr19

35996888

-
5CDS-5UTRENST00000345162ENST00000488892ABCC9chr12

22028588

-DMKNchr19

35996888

-
5CDS-5UTRENST00000345162ENST00000488892ABCC9chr12

22028587

-DMKNchr19

35996888

-
5CDS-5UTRENST00000345162ENST00000492341ABCC9chr12

22028588

-DMKNchr19

35996888

-
5CDS-5UTRENST00000345162ENST00000492341ABCC9chr12

22028587

-DMKNchr19

35996888

-
5CDS-5UTRENST00000345162ENST00000602781ABCC9chr12

22028588

-DMKNchr19

35996888

-
5CDS-5UTRENST00000345162ENST00000602781ABCC9chr12

22028587

-DMKNchr19

35996888

-
5CDS-intronENST00000261200ENST00000339686ABCC9chr12

22028588

-DMKNchr19

35996888

-
5CDS-intronENST00000261200ENST00000339686ABCC9chr12

22028587

-DMKNchr19

35996888

-
5CDS-intronENST00000261200ENST00000402589ABCC9chr12

22028588

-DMKNchr19

35996888

-
5CDS-intronENST00000261200ENST00000402589ABCC9chr12

22028587

-DMKNchr19

35996888

-
5CDS-intronENST00000261200ENST00000408915ABCC9chr12

22028588

-DMKNchr19

35996888

-
5CDS-intronENST00000261200ENST00000408915ABCC9chr12

22028587

-DMKNchr19

35996888

-
5CDS-intronENST00000261200ENST00000414866ABCC9chr12

22028588

-DMKNchr19

35996888

-
5CDS-intronENST00000261200ENST00000414866ABCC9chr12

22028587

-DMKNchr19

35996888

-
5CDS-intronENST00000261200ENST00000419602ABCC9chr12

22028588

-DMKNchr19

35996888

-
5CDS-intronENST00000261200ENST00000419602ABCC9chr12

22028587

-DMKNchr19

35996888

-
5CDS-intronENST00000261200ENST00000429837ABCC9chr12

22028588

-DMKNchr19

35996888

-
5CDS-intronENST00000261200ENST00000429837ABCC9chr12

22028587

-DMKNchr19

35996888

-
5CDS-intronENST00000261200ENST00000436012ABCC9chr12

22028588

-DMKNchr19

35996888

-
5CDS-intronENST00000261200ENST00000436012ABCC9chr12

22028587

-DMKNchr19

35996888

-
5CDS-intronENST00000261200ENST00000467637ABCC9chr12

22028588

-DMKNchr19

35996888

-
5CDS-intronENST00000261200ENST00000467637ABCC9chr12

22028587

-DMKNchr19

35996888

-
5CDS-intronENST00000261200ENST00000480502ABCC9chr12

22028588

-DMKNchr19

35996888

-
5CDS-intronENST00000261200ENST00000480502ABCC9chr12

22028587

-DMKNchr19

35996888

-
5CDS-intronENST00000261201ENST00000339686ABCC9chr12

22028588

-DMKNchr19

35996888

-
5CDS-intronENST00000261201ENST00000339686ABCC9chr12

22028587

-DMKNchr19

35996888

-
5CDS-intronENST00000261201ENST00000402589ABCC9chr12

22028588

-DMKNchr19

35996888

-
5CDS-intronENST00000261201ENST00000402589ABCC9chr12

22028587

-DMKNchr19

35996888

-
5CDS-intronENST00000261201ENST00000408915ABCC9chr12

22028588

-DMKNchr19

35996888

-
5CDS-intronENST00000261201ENST00000408915ABCC9chr12

22028587

-DMKNchr19

35996888

-
5CDS-intronENST00000261201ENST00000414866ABCC9chr12

22028588

-DMKNchr19

35996888

-
5CDS-intronENST00000261201ENST00000414866ABCC9chr12

22028587

-DMKNchr19

35996888

-
5CDS-intronENST00000261201ENST00000419602ABCC9chr12

22028588

-DMKNchr19

35996888

-
5CDS-intronENST00000261201ENST00000419602ABCC9chr12

22028587

-DMKNchr19

35996888

-
5CDS-intronENST00000261201ENST00000429837ABCC9chr12

22028588

-DMKNchr19

35996888

-
5CDS-intronENST00000261201ENST00000429837ABCC9chr12

22028587

-DMKNchr19

35996888

-
5CDS-intronENST00000261201ENST00000436012ABCC9chr12

22028588

-DMKNchr19

35996888

-
5CDS-intronENST00000261201ENST00000436012ABCC9chr12

22028587

-DMKNchr19

35996888

-
5CDS-intronENST00000261201ENST00000467637ABCC9chr12

22028588

-DMKNchr19

35996888

-
5CDS-intronENST00000261201ENST00000467637ABCC9chr12

22028587

-DMKNchr19

35996888

-
5CDS-intronENST00000261201ENST00000480502ABCC9chr12

22028588

-DMKNchr19

35996888

-
5CDS-intronENST00000261201ENST00000480502ABCC9chr12

22028587

-DMKNchr19

35996888

-
5CDS-intronENST00000345162ENST00000339686ABCC9chr12

22028588

-DMKNchr19

35996888

-
5CDS-intronENST00000345162ENST00000339686ABCC9chr12

22028587

-DMKNchr19

35996888

-
5CDS-intronENST00000345162ENST00000402589ABCC9chr12

22028588

-DMKNchr19

35996888

-
5CDS-intronENST00000345162ENST00000402589ABCC9chr12

22028587

-DMKNchr19

35996888

-
5CDS-intronENST00000345162ENST00000408915ABCC9chr12

22028588

-DMKNchr19

35996888

-
5CDS-intronENST00000345162ENST00000408915ABCC9chr12

22028587

-DMKNchr19

35996888

-
5CDS-intronENST00000345162ENST00000414866ABCC9chr12

22028588

-DMKNchr19

35996888

-
5CDS-intronENST00000345162ENST00000414866ABCC9chr12

22028587

-DMKNchr19

35996888

-
5CDS-intronENST00000345162ENST00000419602ABCC9chr12

22028588

-DMKNchr19

35996888

-
5CDS-intronENST00000345162ENST00000419602ABCC9chr12

22028587

-DMKNchr19

35996888

-
5CDS-intronENST00000345162ENST00000429837ABCC9chr12

22028588

-DMKNchr19

35996888

-
5CDS-intronENST00000345162ENST00000429837ABCC9chr12

22028587

-DMKNchr19

35996888

-
5CDS-intronENST00000345162ENST00000436012ABCC9chr12

22028588

-DMKNchr19

35996888

-
5CDS-intronENST00000345162ENST00000436012ABCC9chr12

22028587

-DMKNchr19

35996888

-
5CDS-intronENST00000345162ENST00000467637ABCC9chr12

22028588

-DMKNchr19

35996888

-
5CDS-intronENST00000345162ENST00000467637ABCC9chr12

22028587

-DMKNchr19

35996888

-
5CDS-intronENST00000345162ENST00000480502ABCC9chr12

22028588

-DMKNchr19

35996888

-
5CDS-intronENST00000345162ENST00000480502ABCC9chr12

22028587

-DMKNchr19

35996888

-
intron-5UTRENST00000326684ENST00000392206ABCC9chr12

22028588

-DMKNchr19

35996888

-
intron-5UTRENST00000326684ENST00000392206ABCC9chr12

22028587

-DMKNchr19

35996888

-
intron-5UTRENST00000326684ENST00000418261ABCC9chr12

22028588

-DMKNchr19

35996888

-
intron-5UTRENST00000326684ENST00000418261ABCC9chr12

22028587

-DMKNchr19

35996888

-
intron-5UTRENST00000326684ENST00000424570ABCC9chr12

22028588

-DMKNchr19

35996888

-
intron-5UTRENST00000326684ENST00000424570ABCC9chr12

22028587

-DMKNchr19

35996888

-
intron-5UTRENST00000326684ENST00000440396ABCC9chr12

22028588

-DMKNchr19

35996888

-
intron-5UTRENST00000326684ENST00000440396ABCC9chr12

22028587

-DMKNchr19

35996888

-
intron-5UTRENST00000326684ENST00000443640ABCC9chr12

22028588

-DMKNchr19

35996888

-
intron-5UTRENST00000326684ENST00000443640ABCC9chr12

22028587

-DMKNchr19

35996888

-
intron-5UTRENST00000326684ENST00000447113ABCC9chr12

22028588

-DMKNchr19

35996888

-
intron-5UTRENST00000326684ENST00000447113ABCC9chr12

22028587

-DMKNchr19

35996888

-
intron-5UTRENST00000326684ENST00000451297ABCC9chr12

22028588

-DMKNchr19

35996888

-
intron-5UTRENST00000326684ENST00000451297ABCC9chr12

22028587

-DMKNchr19

35996888

-
intron-5UTRENST00000326684ENST00000458071ABCC9chr12

22028588

-DMKNchr19

35996888

-
intron-5UTRENST00000326684ENST00000458071ABCC9chr12

22028587

-DMKNchr19

35996888

-
intron-5UTRENST00000326684ENST00000461300ABCC9chr12

22028588

-DMKNchr19

35996888

-
intron-5UTRENST00000326684ENST00000461300ABCC9chr12

22028587

-DMKNchr19

35996888

-
intron-5UTRENST00000326684ENST00000462126ABCC9chr12

22028588

-DMKNchr19

35996888

-
intron-5UTRENST00000326684ENST00000462126ABCC9chr12

22028587

-DMKNchr19

35996888

-
intron-5UTRENST00000326684ENST00000472252ABCC9chr12

22028588

-DMKNchr19

35996888

-
intron-5UTRENST00000326684ENST00000472252ABCC9chr12

22028587

-DMKNchr19

35996888

-
intron-5UTRENST00000326684ENST00000474928ABCC9chr12

22028588

-DMKNchr19

35996888

-
intron-5UTRENST00000326684ENST00000474928ABCC9chr12

22028587

-DMKNchr19

35996888

-
intron-5UTRENST00000326684ENST00000488892ABCC9chr12

22028588

-DMKNchr19

35996888

-
intron-5UTRENST00000326684ENST00000488892ABCC9chr12

22028587

-DMKNchr19

35996888

-
intron-5UTRENST00000326684ENST00000492341ABCC9chr12

22028588

-DMKNchr19

35996888

-
intron-5UTRENST00000326684ENST00000492341ABCC9chr12

22028587

-DMKNchr19

35996888

-
intron-5UTRENST00000326684ENST00000602781ABCC9chr12

22028588

-DMKNchr19

35996888

-
intron-5UTRENST00000326684ENST00000602781ABCC9chr12

22028587

-DMKNchr19

35996888

-
intron-5UTRENST00000538350ENST00000392206ABCC9chr12

22028588

-DMKNchr19

35996888

-
intron-5UTRENST00000538350ENST00000392206ABCC9chr12

22028587

-DMKNchr19

35996888

-
intron-5UTRENST00000538350ENST00000418261ABCC9chr12

22028588

-DMKNchr19

35996888

-
intron-5UTRENST00000538350ENST00000418261ABCC9chr12

22028587

-DMKNchr19

35996888

-
intron-5UTRENST00000538350ENST00000424570ABCC9chr12

22028588

-DMKNchr19

35996888

-
intron-5UTRENST00000538350ENST00000424570ABCC9chr12

22028587

-DMKNchr19

35996888

-
intron-5UTRENST00000538350ENST00000440396ABCC9chr12

22028588

-DMKNchr19

35996888

-
intron-5UTRENST00000538350ENST00000440396ABCC9chr12

22028587

-DMKNchr19

35996888

-
intron-5UTRENST00000538350ENST00000443640ABCC9chr12

22028588

-DMKNchr19

35996888

-
intron-5UTRENST00000538350ENST00000443640ABCC9chr12

22028587

-DMKNchr19

35996888

-
intron-5UTRENST00000538350ENST00000447113ABCC9chr12

22028588

-DMKNchr19

35996888

-
intron-5UTRENST00000538350ENST00000447113ABCC9chr12

22028587

-DMKNchr19

35996888

-
intron-5UTRENST00000538350ENST00000451297ABCC9chr12

22028588

-DMKNchr19

35996888

-
intron-5UTRENST00000538350ENST00000451297ABCC9chr12

22028587

-DMKNchr19

35996888

-
intron-5UTRENST00000538350ENST00000458071ABCC9chr12

22028588

-DMKNchr19

35996888

-
intron-5UTRENST00000538350ENST00000458071ABCC9chr12

22028587

-DMKNchr19

35996888

-
intron-5UTRENST00000538350ENST00000461300ABCC9chr12

22028588

-DMKNchr19

35996888

-
intron-5UTRENST00000538350ENST00000461300ABCC9chr12

22028587

-DMKNchr19

35996888

-
intron-5UTRENST00000538350ENST00000462126ABCC9chr12

22028588

-DMKNchr19

35996888

-
intron-5UTRENST00000538350ENST00000462126ABCC9chr12

22028587

-DMKNchr19

35996888

-
intron-5UTRENST00000538350ENST00000472252ABCC9chr12

22028588

-DMKNchr19

35996888

-
intron-5UTRENST00000538350ENST00000472252ABCC9chr12

22028587

-DMKNchr19

35996888

-
intron-5UTRENST00000538350ENST00000474928ABCC9chr12

22028588

-DMKNchr19

35996888

-
intron-5UTRENST00000538350ENST00000474928ABCC9chr12

22028587

-DMKNchr19

35996888

-
intron-5UTRENST00000538350ENST00000488892ABCC9chr12

22028588

-DMKNchr19

35996888

-
intron-5UTRENST00000538350ENST00000488892ABCC9chr12

22028587

-DMKNchr19

35996888

-
intron-5UTRENST00000538350ENST00000492341ABCC9chr12

22028588

-DMKNchr19

35996888

-
intron-5UTRENST00000538350ENST00000492341ABCC9chr12

22028587

-DMKNchr19

35996888

-
intron-5UTRENST00000538350ENST00000602781ABCC9chr12

22028588

-DMKNchr19

35996888

-
intron-5UTRENST00000538350ENST00000602781ABCC9chr12

22028587

-DMKNchr19

35996888

-
intron-intronENST00000326684ENST00000339686ABCC9chr12

22028588

-DMKNchr19

35996888

-
intron-intronENST00000326684ENST00000339686ABCC9chr12

22028587

-DMKNchr19

35996888

-
intron-intronENST00000326684ENST00000402589ABCC9chr12

22028588

-DMKNchr19

35996888

-
intron-intronENST00000326684ENST00000402589ABCC9chr12

22028587

-DMKNchr19

35996888

-
intron-intronENST00000326684ENST00000408915ABCC9chr12

22028588

-DMKNchr19

35996888

-
intron-intronENST00000326684ENST00000408915ABCC9chr12

22028587

-DMKNchr19

35996888

-
intron-intronENST00000326684ENST00000414866ABCC9chr12

22028588

-DMKNchr19

35996888

-
intron-intronENST00000326684ENST00000414866ABCC9chr12

22028587

-DMKNchr19

35996888

-
intron-intronENST00000326684ENST00000419602ABCC9chr12

22028588

-DMKNchr19

35996888

-
intron-intronENST00000326684ENST00000419602ABCC9chr12

22028587

-DMKNchr19

35996888

-
intron-intronENST00000326684ENST00000429837ABCC9chr12

22028588

-DMKNchr19

35996888

-
intron-intronENST00000326684ENST00000429837ABCC9chr12

22028587

-DMKNchr19

35996888

-
intron-intronENST00000326684ENST00000436012ABCC9chr12

22028588

-DMKNchr19

35996888

-
intron-intronENST00000326684ENST00000436012ABCC9chr12

22028587

-DMKNchr19

35996888

-
intron-intronENST00000326684ENST00000467637ABCC9chr12

22028588

-DMKNchr19

35996888

-
intron-intronENST00000326684ENST00000467637ABCC9chr12

22028587

-DMKNchr19

35996888

-
intron-intronENST00000326684ENST00000480502ABCC9chr12

22028588

-DMKNchr19

35996888

-
intron-intronENST00000326684ENST00000480502ABCC9chr12

22028587

-DMKNchr19

35996888

-
intron-intronENST00000538350ENST00000339686ABCC9chr12

22028588

-DMKNchr19

35996888

-
intron-intronENST00000538350ENST00000339686ABCC9chr12

22028587

-DMKNchr19

35996888

-
intron-intronENST00000538350ENST00000402589ABCC9chr12

22028588

-DMKNchr19

35996888

-
intron-intronENST00000538350ENST00000402589ABCC9chr12

22028587

-DMKNchr19

35996888

-
intron-intronENST00000538350ENST00000408915ABCC9chr12

22028588

-DMKNchr19

35996888

-
intron-intronENST00000538350ENST00000408915ABCC9chr12

22028587

-DMKNchr19

35996888

-
intron-intronENST00000538350ENST00000414866ABCC9chr12

22028588

-DMKNchr19

35996888

-
intron-intronENST00000538350ENST00000414866ABCC9chr12

22028587

-DMKNchr19

35996888

-
intron-intronENST00000538350ENST00000419602ABCC9chr12

22028588

-DMKNchr19

35996888

-
intron-intronENST00000538350ENST00000419602ABCC9chr12

22028587

-DMKNchr19

35996888

-
intron-intronENST00000538350ENST00000429837ABCC9chr12

22028588

-DMKNchr19

35996888

-
intron-intronENST00000538350ENST00000429837ABCC9chr12

22028587

-DMKNchr19

35996888

-
intron-intronENST00000538350ENST00000436012ABCC9chr12

22028588

-DMKNchr19

35996888

-
intron-intronENST00000538350ENST00000436012ABCC9chr12

22028587

-DMKNchr19

35996888

-
intron-intronENST00000538350ENST00000467637ABCC9chr12

22028588

-DMKNchr19

35996888

-
intron-intronENST00000538350ENST00000467637ABCC9chr12

22028587

-DMKNchr19

35996888

-
intron-intronENST00000538350ENST00000480502ABCC9chr12

22028588

-DMKNchr19

35996888

-
intron-intronENST00000538350ENST00000480502ABCC9chr12

22028587

-DMKNchr19

35996888

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

Top

Fusion Genomic Features for ABCC9-DMKN


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)


Top

Fusion Protein Features for ABCC9-DMKN


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:22028588/:35996888)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

Fusion Gene Sequence for ABCC9-DMKN


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

Top

Fusion Gene PPI Analysis for ABCC9-DMKN


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for ABCC9-DMKN


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for ABCC9-DMKN


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneABCC9C0795905Cantu syndrome7CLINGEN;CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
HgeneABCC9C3279695ATRIAL FIBRILLATION, FAMILIAL, 125CTD_human;GENOMICS_ENGLAND;UNIPROT
HgeneABCC9C1837839CARDIOMYOPATHY, DILATED, 1O4CTD_human;GENOMICS_ENGLAND;UNIPROT
HgeneABCC9C0004238Atrial Fibrillation1GENOMICS_ENGLAND
HgeneABCC9C0007193Cardiomyopathy, Dilated1GENOMICS_ENGLAND
HgeneABCC9C0014170Endometrial Neoplasms1CTD_human
HgeneABCC9C0014175Endometriosis1CTD_human
HgeneABCC9C0042514Tachycardia, Ventricular1GENOMICS_ENGLAND
HgeneABCC9C0086132Depressive Symptoms1PSYGENET
HgeneABCC9C0151879Shortened QT interval1GENOMICS_ENGLAND
HgeneABCC9C0269102Endometrioma1CTD_human
HgeneABCC9C0340427Familial dilated cardiomyopathy1ORPHANET
HgeneABCC9C0476089Endometrial Carcinoma1CTD_human
HgeneABCC9C0796280Acromegaloid facial appearance syndrome1ORPHANET
HgeneABCC9C1142166Brugada Syndrome (disorder)1GENOMICS_ENGLAND;ORPHANET
HgeneABCC9C1843687ATRIAL FIBRILLATION, FAMILIAL, 1 (disorder)1ORPHANET