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in Kim Lab

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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ATP9A-WFDC8 (FusionGDB2 ID:HG10079TG90199)

Fusion Gene Summary for ATP9A-WFDC8

check button Fusion gene summary
Fusion gene informationFusion gene name: ATP9A-WFDC8
Fusion gene ID: hg10079tg90199
HgeneTgene
Gene symbol

ATP9A

WFDC8

Gene ID

10079

90199

Gene nameATPase phospholipid transporting 9A (putative)WAP four-disulfide core domain 8
SynonymsATPIIAC20orf170|HEL-S-292|WAP8|dJ461P17.1
Cytomap('ATP9A')('WFDC8')

20q13.2

20q13.12

Type of geneprotein-codingprotein-coding
Descriptionprobable phospholipid-transporting ATPase IIAATPase type IV, phospholipid-transporting (P-type),(putative)ATPase, class II, type 9Aphospholipid-transporting ATPase IIAWAP four-disulfide core domain protein 8WAP motif protein 1epididymis secretory protein Li 292epididymis secretory sperm binding proteinprotease inhibitor WAP8putative protease inhibitor WAP8testicular secretory protein Li 68
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000311637, ENST00000338821, 
ENST00000402822, ENST00000477492, 
Fusion gene scores* DoF score15 X 13 X 10=19503 X 2 X 3=18
# samples 163
** MAII scorelog2(16/1950*10)=-3.60733031374961
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: ATP9A [Title/Abstract] AND WFDC8 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointATP9A(50286536)-WFDC8(44190858), # samples:1
Anticipated loss of major functional domain due to fusion event.ATP9A-WFDC8 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ATP9A-WFDC8 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ATP9A-WFDC8 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
ATP9A-WFDC8 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across ATP9A (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across WFDC8 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4COADTCGA-AD-6965-01AATP9Achr20

50286536

-WFDC8chr20

44190858

-


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Fusion Gene ORF analysis for ATP9A-WFDC8

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000311637ENST00000289953ATP9Achr20

50286536

-WFDC8chr20

44190858

-
Frame-shiftENST00000338821ENST00000289953ATP9Achr20

50286536

-WFDC8chr20

44190858

-
Frame-shiftENST00000402822ENST00000289953ATP9Achr20

50286536

-WFDC8chr20

44190858

-
In-frameENST00000311637ENST00000357199ATP9Achr20

50286536

-WFDC8chr20

44190858

-
In-frameENST00000338821ENST00000357199ATP9Achr20

50286536

-WFDC8chr20

44190858

-
In-frameENST00000402822ENST00000357199ATP9Achr20

50286536

-WFDC8chr20

44190858

-
intron-3CDSENST00000477492ENST00000289953ATP9Achr20

50286536

-WFDC8chr20

44190858

-
intron-3CDSENST00000477492ENST00000357199ATP9Achr20

50286536

-WFDC8chr20

44190858

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000311637ATP9Achr2050286536-ENST00000357199WFDC8chr2044190858-20528894906300
ENST00000338821ATP9Achr2050286536-ENST00000357199WFDC8chr2044190858-272115581241575483
ENST00000402822ATP9Achr2050286536-ENST00000357199WFDC8chr2044190858-20939300947315

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000311637ENST00000357199ATP9Achr2050286536-WFDC8chr2044190858-0.0015943110.99840575
ENST00000338821ENST00000357199ATP9Achr2050286536-WFDC8chr2044190858-0.0034401090.9965599
ENST00000402822ENST00000357199ATP9Achr2050286536-WFDC8chr2044190858-0.002091780.99790823

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Fusion Genomic Features for ATP9A-WFDC8


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

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Fusion Protein Features for ATP9A-WFDC8


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr20:50286536/chr20:44190858)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneATP9Achr20:50286536chr20:44190858ENST00000338821-1328120_3034311048.0Topological domainCytoplasmic
HgeneATP9Achr20:50286536chr20:44190858ENST00000338821-13282_694311048.0Topological domainCytoplasmic
HgeneATP9Achr20:50286536chr20:44190858ENST00000338821-1328326_3324311048.0Topological domainExtracellular
HgeneATP9Achr20:50286536chr20:44190858ENST00000338821-132892_964311048.0Topological domainExtracellular
HgeneATP9Achr20:50286536chr20:44190858ENST00000402822-823120_303310927.0Topological domainCytoplasmic
HgeneATP9Achr20:50286536chr20:44190858ENST00000402822-8232_69310927.0Topological domainCytoplasmic
HgeneATP9Achr20:50286536chr20:44190858ENST00000402822-82392_96310927.0Topological domainExtracellular
HgeneATP9Achr20:50286536chr20:44190858ENST00000338821-1328304_3254311048.0TransmembraneHelical
HgeneATP9Achr20:50286536chr20:44190858ENST00000338821-1328333_3544311048.0TransmembraneHelical
HgeneATP9Achr20:50286536chr20:44190858ENST00000338821-132870_914311048.0TransmembraneHelical
HgeneATP9Achr20:50286536chr20:44190858ENST00000338821-132897_1194311048.0TransmembraneHelical
HgeneATP9Achr20:50286536chr20:44190858ENST00000402822-82370_91310927.0TransmembraneHelical
HgeneATP9Achr20:50286536chr20:44190858ENST00000402822-82397_119310927.0TransmembraneHelical
TgeneWFDC8chr20:50286536chr20:44190858ENST0000028995306147_1948242.0DomainWAP 2
TgeneWFDC8chr20:50286536chr20:44190858ENST0000028995306195_2408242.0DomainWAP 3
TgeneWFDC8chr20:50286536chr20:44190858ENST000002899530644_918242.0DomainWAP 1
TgeneWFDC8chr20:50286536chr20:44190858ENST0000035719907147_1948371.3333333333333DomainWAP 2
TgeneWFDC8chr20:50286536chr20:44190858ENST0000035719907195_2408371.3333333333333DomainWAP 3
TgeneWFDC8chr20:50286536chr20:44190858ENST000003571990744_918371.3333333333333DomainWAP 1

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneATP9Achr20:50286536chr20:44190858ENST00000338821-13281000_10064311048.0Topological domainExtracellular
HgeneATP9Achr20:50286536chr20:44190858ENST00000338821-13281031_10474311048.0Topological domainCytoplasmic
HgeneATP9Achr20:50286536chr20:44190858ENST00000338821-1328355_8414311048.0Topological domainCytoplasmic
HgeneATP9Achr20:50286536chr20:44190858ENST00000338821-1328863_8744311048.0Topological domainExtracellular
HgeneATP9Achr20:50286536chr20:44190858ENST00000338821-1328894_9234311048.0Topological domainCytoplasmic
HgeneATP9Achr20:50286536chr20:44190858ENST00000338821-1328943_9494311048.0Topological domainExtracellular
HgeneATP9Achr20:50286536chr20:44190858ENST00000338821-1328973_9784311048.0Topological domainCytoplasmic
HgeneATP9Achr20:50286536chr20:44190858ENST00000402822-8231000_1006310927.0Topological domainExtracellular
HgeneATP9Achr20:50286536chr20:44190858ENST00000402822-8231031_1047310927.0Topological domainCytoplasmic
HgeneATP9Achr20:50286536chr20:44190858ENST00000402822-823326_332310927.0Topological domainExtracellular
HgeneATP9Achr20:50286536chr20:44190858ENST00000402822-823355_841310927.0Topological domainCytoplasmic
HgeneATP9Achr20:50286536chr20:44190858ENST00000402822-823863_874310927.0Topological domainExtracellular
HgeneATP9Achr20:50286536chr20:44190858ENST00000402822-823894_923310927.0Topological domainCytoplasmic
HgeneATP9Achr20:50286536chr20:44190858ENST00000402822-823943_949310927.0Topological domainExtracellular
HgeneATP9Achr20:50286536chr20:44190858ENST00000402822-823973_978310927.0Topological domainCytoplasmic
HgeneATP9Achr20:50286536chr20:44190858ENST00000338821-13281007_10304311048.0TransmembraneHelical
HgeneATP9Achr20:50286536chr20:44190858ENST00000338821-1328842_8624311048.0TransmembraneHelical
HgeneATP9Achr20:50286536chr20:44190858ENST00000338821-1328875_8934311048.0TransmembraneHelical
HgeneATP9Achr20:50286536chr20:44190858ENST00000338821-1328924_9424311048.0TransmembraneHelical
HgeneATP9Achr20:50286536chr20:44190858ENST00000338821-1328950_9724311048.0TransmembraneHelical
HgeneATP9Achr20:50286536chr20:44190858ENST00000338821-1328979_9994311048.0TransmembraneHelical
HgeneATP9Achr20:50286536chr20:44190858ENST00000402822-8231007_1030310927.0TransmembraneHelical
HgeneATP9Achr20:50286536chr20:44190858ENST00000402822-823304_325310927.0TransmembraneHelical
HgeneATP9Achr20:50286536chr20:44190858ENST00000402822-823333_354310927.0TransmembraneHelical
HgeneATP9Achr20:50286536chr20:44190858ENST00000402822-823842_862310927.0TransmembraneHelical
HgeneATP9Achr20:50286536chr20:44190858ENST00000402822-823875_893310927.0TransmembraneHelical
HgeneATP9Achr20:50286536chr20:44190858ENST00000402822-823924_942310927.0TransmembraneHelical
HgeneATP9Achr20:50286536chr20:44190858ENST00000402822-823950_972310927.0TransmembraneHelical
HgeneATP9Achr20:50286536chr20:44190858ENST00000402822-823979_999310927.0TransmembraneHelical


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Fusion Gene Sequence for ATP9A-WFDC8


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>8291_8291_1_ATP9A-WFDC8_ATP9A_chr20_50286536_ENST00000311637_WFDC8_chr20_44190858_ENST00000357199_length(transcript)=2052nt_BP=889nt
GCGGATGGACAGCAGGCCCCGCGCCGGGTGCTGCGAGTGGCTGAGATGCTGCGGTGGAGGGGAGGCCAGGCCCCGCACTGTCTGGCTGGG
GCACCCCGAGAAGAGAGACCAGAGGTATCCTCGGAATGTCATCAACAATCAGAAGTACAATTTCTTCACCTTTCTTCCTGGGGTGCTGTT
CAACCAGTTCAAATACTTTTTCAACCTCTATTTCTTACTTCTTGCCTGCTCTCAGTTTGTTCCCGAAATGAGACTTGGTGCACTCTATAC
CTACTGGGTTCCCCTGGGCTTCGTGCTGGCCGTCACTGTCATCCGTGAGGCGGTGGAGGAGATCCGATGCTACGTGCGGGACAAGGAAGT
CAACTCCCAGGTCTACAGCCGGCTCACAGCACGAGGTACTGTTGTGGGTGTTGTTCTTTACACTGGCAGAGAACTCCGGAGTGTCATGAA
TACCTCAAATCCCCGAAGTAAGATCGGCCTGTTCGACTTGGAAGTGAACTGCCTCACCAAGATCCTCTTTGGTGCCCTGGTGGTGGTCTC
GCTGGTCATGGTTGCCCTTCAGCACTTTGCAGGCCGTTGGTACCTGCAGATCATCCGCTTCCTCCTCTTGTTTTCCAACATCATCCCCAT
TAGTTTGCGTGTGAACCTGGACATGGGCAAGATCGTGTACAGCTGGGTGATTCGAAGGGACTCGAAAATCCCCGGGACCGTGGTTCGCTC
CAGCACGATTCCTGAGCAGCTGGGCAGGATTTCGTACTTACTCACAGACAAGACAGGCACTCTTACCCAGAACGAGATGATTTTCAAACG
GCTCCATCTCGGAACAGTAGCCTACGGCCTCGACTCAATGGACGAAGTACAAAGCCACATTTTCAGCATTTACACCCAGGCACTTTCCTC
TCCATAGCCCCACCTTCTCCTGGAGGAATGTAGCTTTCCTGCTGCTTCTCTCCCTTGCTTTGGAGTGGACTTCTGCAATGCTGACCAAGA
AGATCAAACACAAACCAGGGTTATGTCCCAAAGAGAGGCTCACCTGTACCACTGAACTTCCGGACTCATGTAACACAGATTTTGACTGCA
AGGAATACCAGAAGTGCTGCTTTTTTGCCTGTCAGAAGAAGTGCATGGATCCCTTTCAAGAACCCTGCATGCTACCTGTGAGGCATGGAA
ACTGTAATCATGAGGCACAGCGCTGGCATTTTGACTTTAAAAATTACCGCTGCACACCCTTCAAATACAGGGGCTGCGAAGGGAATGCCA
ACAACTTCTTAAATGAGGATGCCTGCAGAACGGCCTGCATGTTAATTGTTAAGGATGGACAATGCCCACTCTTCCCTTTCACTGAACGTA
AGGAGTGTCCACCTTCATGTCACAGTGACATCGATTGTCCCCAGACAGACAAATGTTGTGAATCCAGGTGTGGCTTTGTTTGTGCCAGGG
CCTGGACAGTCAAAAAAGGTTTCTGCCCACGCAAGCCCTTGCTATGTACCAAGATTGATAAACCCAAGTGCCTGCAGGATGAGGAGTGCC
CATTGGTGGAAAAGTGCTGCTCACATTGTGGACTGAAATGTATGGACCCCAGACGTTGAATAACGGAGTTTTGCTCTTATTGCCCAGGCG
CAATCTCGGCTCACTGCAACCTCTGCTTCCCGGGTTCAAGTGATTCTCCTGCCTCAGCCTCCCAAGTAGCTGGGATTACAGGTGCCCACC
ATCATGCCCAGCTAATTTTTTGTATTTTTAGTAGAGATGGGGTTTTACCATGTTGGCCAAGCTGGTCACAAACTCCTGACCTCAGGTGAT
CCACCCACCTCAGCCTCCGAAAGTGCTGGGATCACAGGTGGGAGCCACTGTGCCTGGCCAGTTATTTCCTTTTTAAGCCTATTTCCTATC
CATTTATAGCTACTACTGAAAATGACTACTGAATTTTATCAAATACCTTTTAAGCATACAGTCACATAATGATTTTTCTCTTCTAATTTG

>8291_8291_1_ATP9A-WFDC8_ATP9A_chr20_50286536_ENST00000311637_WFDC8_chr20_44190858_ENST00000357199_length(amino acids)=300AA_BP=
MDSRPRAGCCEWLRCCGGGEARPRTVWLGHPEKRDQRYPRNVINNQKYNFFTFLPGVLFNQFKYFFNLYFLLLACSQFVPEMRLGALYTY
WVPLGFVLAVTVIREAVEEIRCYVRDKEVNSQVYSRLTARGTVVGVVLYTGRELRSVMNTSNPRSKIGLFDLEVNCLTKILFGALVVVSL
VMVALQHFAGRWYLQIIRFLLLFSNIIPISLRVNLDMGKIVYSWVIRRDSKIPGTVVRSSTIPEQLGRISYLLTDKTGTLTQNEMIFKRL

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>8291_8291_2_ATP9A-WFDC8_ATP9A_chr20_50286536_ENST00000338821_WFDC8_chr20_44190858_ENST00000357199_length(transcript)=2721nt_BP=1558nt
GCGCGGCGCGGCGCGGAGCGAGCGGGCGCAGCGCGGAGCTCGGGCCCATGGTGCGCCCGTGTCCGTCGGTCGGGCCGCGCGGGCGCTCCG
CGCGTGGCCCGGCGCTCGCGAGCTCGCCCCCTCGCTGCGGGCCCGGCCCGCCCGCTGCCGCCGCCTCCTCCCCCGGGGCGGCGCGGCGCC
GGCGGGCGGCGGCGCGGAGGCCGGACCGGGCGGCGGCCCAGGCGGCGCGGGGGGCGCGGCGGCCAAGGCGGGCGGCGCCGCCGACATGAC
GGACAACATCCCGCTGCAGCCGGTGCGCCAGAAGAAGCGGATGGACAGCAGGCCCCGCGCCGGGTGCTGCGAGTGGCTGAGATGCTGCGG
TGGAGGGGAGGCCAGGCCCCGCACTGTCTGGCTGGGGCACCCCGAGAAGAGAGACCAGAGGTATCCTCGGAATGTCATCAACAATCAGAA
GTACAATTTCTTCACCTTTCTTCCTGGGGTGCTGTTCAACCAGTTCAAATACTTTTTCAACCTCTATTTCTTACTTCTTGCCTGCTCTCA
GTTTGTTCCCGAAATGAGACTTGGTGCACTCTATACCTACTGGGTTCCCCTGGGCTTCGTGCTGGCCGTCACTGTCATCCGTGAGGCGGT
GGAGGAGATCCGATGCTACGTGCGGGACAAGGAAGTCAACTCCCAGGTCTACAGCCGGCTCACAGCACGAGGCACAGTGAAGGTGAAGAG
TTCTAACATCCAAGTTGGAGACCTTATCATCGTTGAAAAGAACCAGCGGGTCCCTGCCGACATGATCTTCCTGAGGACATCAGAAAAAAA
CGGGTCATGCTTCTTGCGGACGGATCAGCTGGATGGGGAGACGGACTGGAAGCTGCGGCTTCCCGTGGCCTGCACGCAGAGGCTCCCCAC
GGCCGCCGACCTTCTTCAGATTCGATCGTATGTGTACGCAGAAGAGCCAAATATTGACATTCACAACTTCGTGGGAACTTTTACCCGAGA
AGACAGCGACCCCCCGATCAGCGAGAGCCTGAGCATAGAGAACACGCTGTGGGCTGGCACTGTGGTCGCATCAGGTACTGTTGTGGGTGT
TGTTCTTTACACTGGCAGAGAACTCCGGAGTGTCATGAATACCTCAAATCCCCGAAGTAAGATCGGCCTGTTCGACTTGGAAGTGAACTG
CCTCACCAAGATCCTCTTTGGTGCCCTGGTGGTGGTCTCGCTGGTCATGGTTGCCCTTCAGCACTTTGCAGGCCGTTGGTACCTGCAGAT
CATCCGCTTCCTCCTCTTGTTTTCCAACATCATCCCCATTAGTTTGCGTGTGAACCTGGACATGGGCAAGATCGTGTACAGCTGGGTGAT
TCGAAGGGACTCGAAAATCCCCGGGACCGTGGTTCGCTCCAGCACGATTCCTGAGCAGCTGGGCAGGATTTCGTACTTACTCACAGACAA
GACAGGCACTCTTACCCAGAACGAGATGATTTTCAAACGGCTCCATCTCGGAACAGTAGCCTACGGCCTCGACTCAATGGACGAAGTACA
AAGCCACATTTTCAGCATTTACACCCAGGCACTTTCCTCTCCATAGCCCCACCTTCTCCTGGAGGAATGTAGCTTTCCTGCTGCTTCTCT
CCCTTGCTTTGGAGTGGACTTCTGCAATGCTGACCAAGAAGATCAAACACAAACCAGGGTTATGTCCCAAAGAGAGGCTCACCTGTACCA
CTGAACTTCCGGACTCATGTAACACAGATTTTGACTGCAAGGAATACCAGAAGTGCTGCTTTTTTGCCTGTCAGAAGAAGTGCATGGATC
CCTTTCAAGAACCCTGCATGCTACCTGTGAGGCATGGAAACTGTAATCATGAGGCACAGCGCTGGCATTTTGACTTTAAAAATTACCGCT
GCACACCCTTCAAATACAGGGGCTGCGAAGGGAATGCCAACAACTTCTTAAATGAGGATGCCTGCAGAACGGCCTGCATGTTAATTGTTA
AGGATGGACAATGCCCACTCTTCCCTTTCACTGAACGTAAGGAGTGTCCACCTTCATGTCACAGTGACATCGATTGTCCCCAGACAGACA
AATGTTGTGAATCCAGGTGTGGCTTTGTTTGTGCCAGGGCCTGGACAGTCAAAAAAGGTTTCTGCCCACGCAAGCCCTTGCTATGTACCA
AGATTGATAAACCCAAGTGCCTGCAGGATGAGGAGTGCCCATTGGTGGAAAAGTGCTGCTCACATTGTGGACTGAAATGTATGGACCCCA
GACGTTGAATAACGGAGTTTTGCTCTTATTGCCCAGGCGCAATCTCGGCTCACTGCAACCTCTGCTTCCCGGGTTCAAGTGATTCTCCTG
CCTCAGCCTCCCAAGTAGCTGGGATTACAGGTGCCCACCATCATGCCCAGCTAATTTTTTGTATTTTTAGTAGAGATGGGGTTTTACCAT
GTTGGCCAAGCTGGTCACAAACTCCTGACCTCAGGTGATCCACCCACCTCAGCCTCCGAAAGTGCTGGGATCACAGGTGGGAGCCACTGT
GCCTGGCCAGTTATTTCCTTTTTAAGCCTATTTCCTATCCATTTATAGCTACTACTGAAAATGACTACTGAATTTTATCAAATACCTTTT
AAGCATACAGTCACATAATGATTTTTCTCTTCTAATTTGTTGGCATAATAAATTACTAAATTTTCTTGAGCCATCCTTGCATTCTTAATA

>8291_8291_2_ATP9A-WFDC8_ATP9A_chr20_50286536_ENST00000338821_WFDC8_chr20_44190858_ENST00000357199_length(amino acids)=483AA_BP=
MRARPARCRRLLPRGGAAPAGGGAEAGPGGGPGGAGGAAAKAGGAADMTDNIPLQPVRQKKRMDSRPRAGCCEWLRCCGGGEARPRTVWL
GHPEKRDQRYPRNVINNQKYNFFTFLPGVLFNQFKYFFNLYFLLLACSQFVPEMRLGALYTYWVPLGFVLAVTVIREAVEEIRCYVRDKE
VNSQVYSRLTARGTVKVKSSNIQVGDLIIVEKNQRVPADMIFLRTSEKNGSCFLRTDQLDGETDWKLRLPVACTQRLPTAADLLQIRSYV
YAEEPNIDIHNFVGTFTREDSDPPISESLSIENTLWAGTVVASGTVVGVVLYTGRELRSVMNTSNPRSKIGLFDLEVNCLTKILFGALVV
VSLVMVALQHFAGRWYLQIIRFLLLFSNIIPISLRVNLDMGKIVYSWVIRRDSKIPGTVVRSSTIPEQLGRISYLLTDKTGTLTQNEMIF

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>8291_8291_3_ATP9A-WFDC8_ATP9A_chr20_50286536_ENST00000402822_WFDC8_chr20_44190858_ENST00000357199_length(transcript)=2093nt_BP=930nt
ATGACGGACAACATCCCGCTGCAGCCGGTGCGCCAGAAGAAGCGGATGGACAGCAGGCCCCGCGCCGGGTGCTGCGAGTGGCTGAGATGC
TGCGGTGGAGGGGAGGCCAGGCCCCGCACTGTCTGGCTGGGGCACCCCGAGAAGAGAGACCAGAGGTATCCTCGGAATGTCATCAACAAT
CAGAAGTACAATTTCTTCACCTTTCTTCCTGGGGTGCTGTTCAACCAGTTCAAATACTTTTTCAACCTCTATTTCTTACTTCTTGCCTGC
TCTCAGTTTGTTCCCGAAATGAGACTTGGTGCACTCTATACCTACTGGGTTCCCCTGGGCTTCGTGCTGGCCGTCACTGTCATCCGTGAG
GCGGTGGAGGAGATCCGATGCTACGTGCGGGACAAGGAAGTCAACTCCCAGGTCTACAGCCGGCTCACAGCACGAGGTACTGTTGTGGGT
GTTGTTCTTTACACTGGCAGAGAACTCCGGAGTGTCATGAATACCTCAAATCCCCGAAGTAAGATCGGCCTGTTCGACTTGGAAGTGAAC
TGCCTCACCAAGATCCTCTTTGGTGCCCTGGTGGTGGTCTCGCTGGTCATGGTTGCCCTTCAGCACTTTGCAGGCCGTTGGTACCTGCAG
ATCATCCGCTTCCTCCTCTTGTTTTCCAACATCATCCCCATTAGTTTGCGTGTGAACCTGGACATGGGCAAGATCGTGTACAGCTGGGTG
ATTCGAAGGGACTCGAAAATCCCCGGGACCGTGGTTCGCTCCAGCACGATTCCTGAGCAGCTGGGCAGGATTTCGTACTTACTCACAGAC
AAGACAGGCACTCTTACCCAGAACGAGATGATTTTCAAACGGCTCCATCTCGGAACAGTAGCCTACGGCCTCGACTCAATGGACGAAGTA
CAAAGCCACATTTTCAGCATTTACACCCAGGCACTTTCCTCTCCATAGCCCCACCTTCTCCTGGAGGAATGTAGCTTTCCTGCTGCTTCT
CTCCCTTGCTTTGGAGTGGACTTCTGCAATGCTGACCAAGAAGATCAAACACAAACCAGGGTTATGTCCCAAAGAGAGGCTCACCTGTAC
CACTGAACTTCCGGACTCATGTAACACAGATTTTGACTGCAAGGAATACCAGAAGTGCTGCTTTTTTGCCTGTCAGAAGAAGTGCATGGA
TCCCTTTCAAGAACCCTGCATGCTACCTGTGAGGCATGGAAACTGTAATCATGAGGCACAGCGCTGGCATTTTGACTTTAAAAATTACCG
CTGCACACCCTTCAAATACAGGGGCTGCGAAGGGAATGCCAACAACTTCTTAAATGAGGATGCCTGCAGAACGGCCTGCATGTTAATTGT
TAAGGATGGACAATGCCCACTCTTCCCTTTCACTGAACGTAAGGAGTGTCCACCTTCATGTCACAGTGACATCGATTGTCCCCAGACAGA
CAAATGTTGTGAATCCAGGTGTGGCTTTGTTTGTGCCAGGGCCTGGACAGTCAAAAAAGGTTTCTGCCCACGCAAGCCCTTGCTATGTAC
CAAGATTGATAAACCCAAGTGCCTGCAGGATGAGGAGTGCCCATTGGTGGAAAAGTGCTGCTCACATTGTGGACTGAAATGTATGGACCC
CAGACGTTGAATAACGGAGTTTTGCTCTTATTGCCCAGGCGCAATCTCGGCTCACTGCAACCTCTGCTTCCCGGGTTCAAGTGATTCTCC
TGCCTCAGCCTCCCAAGTAGCTGGGATTACAGGTGCCCACCATCATGCCCAGCTAATTTTTTGTATTTTTAGTAGAGATGGGGTTTTACC
ATGTTGGCCAAGCTGGTCACAAACTCCTGACCTCAGGTGATCCACCCACCTCAGCCTCCGAAAGTGCTGGGATCACAGGTGGGAGCCACT
GTGCCTGGCCAGTTATTTCCTTTTTAAGCCTATTTCCTATCCATTTATAGCTACTACTGAAAATGACTACTGAATTTTATCAAATACCTT
TTAAGCATACAGTCACATAATGATTTTTCTCTTCTAATTTGTTGGCATAATAAATTACTAAATTTTCTTGAGCCATCCTTGCATTCTTAA

>8291_8291_3_ATP9A-WFDC8_ATP9A_chr20_50286536_ENST00000402822_WFDC8_chr20_44190858_ENST00000357199_length(amino acids)=315AA_BP=
MTDNIPLQPVRQKKRMDSRPRAGCCEWLRCCGGGEARPRTVWLGHPEKRDQRYPRNVINNQKYNFFTFLPGVLFNQFKYFFNLYFLLLAC
SQFVPEMRLGALYTYWVPLGFVLAVTVIREAVEEIRCYVRDKEVNSQVYSRLTARGTVVGVVLYTGRELRSVMNTSNPRSKIGLFDLEVN
CLTKILFGALVVVSLVMVALQHFAGRWYLQIIRFLLLFSNIIPISLRVNLDMGKIVYSWVIRRDSKIPGTVVRSSTIPEQLGRISYLLTD

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Fusion Gene PPI Analysis for ATP9A-WFDC8


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ATP9A-WFDC8


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ATP9A-WFDC8


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource