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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ARPC2-RNASEH2B (FusionGDB2 ID:HG10109TG79621)

Fusion Gene Summary for ARPC2-RNASEH2B

check button Fusion gene summary
Fusion gene informationFusion gene name: ARPC2-RNASEH2B
Fusion gene ID: hg10109tg79621
HgeneTgene
Gene symbol

ARPC2

RNASEH2B

Gene ID

10109

79621

Gene nameactin related protein 2/3 complex subunit 2ribonuclease H2 subunit B
SynonymsARC34|PNAS-139|PRO2446|p34-ArcAGS2|DLEU8
Cytomap('ARPC2')('RNASEH2B')

2q35

13q14.3

Type of geneprotein-codingprotein-coding
Descriptionactin-related protein 2/3 complex subunit 2ARP2/3 protein complex subunit 34actin related protein 2/3 complex, subunit 2, 34kDaarp2/3 complex 34 kDa subunittestis tissue sperm-binding protein Li 53eribonuclease H2 subunit BAicardi-Goutieres syndrome 2 proteinRNase H2 subunit Bdeleted in lymphocytic leukemia 8ribonuclease HI subunit B
Modification date2020031320200320
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000477992, ENST00000295685, 
ENST00000315717, 
Fusion gene scores* DoF score14 X 13 X 5=91011 X 8 X 8=704
# samples 1612
** MAII scorelog2(16/910*10)=-2.5077946401987
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(12/704*10)=-2.55254102302878
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ARPC2 [Title/Abstract] AND RNASEH2B [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointARPC2(219114644)-RNASEH2B(51519563), # samples:2
Anticipated loss of major functional domain due to fusion event.ARPC2-RNASEH2B seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
ARPC2-RNASEH2B seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneARPC2

GO:0034314

Arp2/3 complex-mediated actin nucleation

11741539

TgeneRNASEH2B

GO:0006401

RNA catabolic process

21177858



check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4MESOTCGA-TS-A8AV-01AARPC2chr2

219114644

+RNASEH2Bchr13

51519563

+
ChimerDB4MESOTCGA-TS-A8AVARPC2chr2

219114644

+RNASEH2Bchr13

51519563

+


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Fusion Gene ORF analysis for ARPC2-RNASEH2B

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000477992ENST00000336617ARPC2chr2

219114644

+RNASEH2Bchr13

51519563

+
3UTR-3CDSENST00000477992ENST00000422660ARPC2chr2

219114644

+RNASEH2Bchr13

51519563

+
3UTR-3UTRENST00000477992ENST00000495244ARPC2chr2

219114644

+RNASEH2Bchr13

51519563

+
5CDS-3UTRENST00000295685ENST00000495244ARPC2chr2

219114644

+RNASEH2Bchr13

51519563

+
5CDS-3UTRENST00000315717ENST00000495244ARPC2chr2

219114644

+RNASEH2Bchr13

51519563

+
Frame-shiftENST00000295685ENST00000336617ARPC2chr2

219114644

+RNASEH2Bchr13

51519563

+
Frame-shiftENST00000295685ENST00000422660ARPC2chr2

219114644

+RNASEH2Bchr13

51519563

+
Frame-shiftENST00000315717ENST00000336617ARPC2chr2

219114644

+RNASEH2Bchr13

51519563

+
Frame-shiftENST00000315717ENST00000422660ARPC2chr2

219114644

+RNASEH2Bchr13

51519563

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for ARPC2-RNASEH2B


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
ARPC2chr2219114644+RNASEH2Bchr1351519562+2.85E-081
ARPC2chr2219114644+RNASEH2Bchr1351519562+2.85E-081
ARPC2chr2219114644+RNASEH2Bchr1351519562+2.85E-081
ARPC2chr2219114644+RNASEH2Bchr1351519562+2.85E-081


check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for ARPC2-RNASEH2B


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:219114644/:51519563)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for ARPC2-RNASEH2B


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for ARPC2-RNASEH2B


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ARPC2-RNASEH2B


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ARPC2-RNASEH2B


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneARPC2C0009324Ulcerative Colitis1CTD_human
TgeneC3489724Aicardi-Goutieres Syndrome 28CTD_human;GENOMICS_ENGLAND;UNIPROT
TgeneC0013421Dystonia1GENOMICS_ENGLAND
TgeneC0037771Paraparesis, Spastic1GENOMICS_ENGLAND
TgeneC0393591AICARDI-GOUTIERES SYNDROME1CTD_human;GENOMICS_ENGLAND
TgeneC3714756Intellectual Disability1GENOMICS_ENGLAND