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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:RAD50-BCLAF1 (FusionGDB2 ID:HG10111TG9774)

Fusion Gene Summary for RAD50-BCLAF1

check button Fusion gene summary
Fusion gene informationFusion gene name: RAD50-BCLAF1
Fusion gene ID: hg10111tg9774
HgeneTgene
Gene symbol

RAD50

BCLAF1

Gene ID

10111

9774

Gene nameRAD50 double strand break repair proteinBCL2 associated transcription factor 1
SynonymsNBSLD|RAD502|hRad50BTF|bK211L9.1
Cytomap('RAD50')('BCLAF1')

5q31.1

6q23.3

Type of geneprotein-codingprotein-coding
DescriptionDNA repair protein RAD50RAD50 homolog, double strand break repair proteinbcl-2-associated transcription factor 1BCLAF1 and THRAP3 family member 1
Modification date2020032020200315
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000265335, ENST00000378823, 
ENST00000487596, 
Fusion gene scores* DoF score9 X 7 X 7=4418 X 6 X 2=96
# samples 108
** MAII scorelog2(10/441*10)=-2.1407786557828
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(8/96*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: RAD50 [Title/Abstract] AND BCLAF1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointRAD50(131895059)-BCLAF1(136582615), # samples:1
Anticipated loss of major functional domain due to fusion event.RAD50-BCLAF1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
RAD50-BCLAF1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
RAD50-BCLAF1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
RAD50-BCLAF1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneRAD50

GO:0000019

regulation of mitotic recombination

8756642

HgeneRAD50

GO:0006281

DNA repair

9705271

HgeneRAD50

GO:0006310

DNA recombination

9705271

HgeneRAD50

GO:0006974

cellular response to DNA damage stimulus

17500065

HgeneRAD50

GO:0007004

telomere maintenance via telomerase

9705271

HgeneRAD50

GO:0031954

positive regulation of protein autophosphorylation

15790808

HgeneRAD50

GO:0033674

positive regulation of kinase activity

15790808

HgeneRAD50

GO:1904354

negative regulation of telomere capping

17694070

TgeneBCLAF1

GO:0043065

positive regulation of apoptotic process

10330179

TgeneBCLAF1

GO:0045892

negative regulation of transcription, DNA-templated

10330179


check buttonFusion gene breakpoints across RAD50 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across BCLAF1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-EQ-8122RAD50chr5

131895059

+BCLAF1chr6

136582615

-


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Fusion Gene ORF analysis for RAD50-BCLAF1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000265335ENST00000392348RAD50chr5

131895059

+BCLAF1chr6

136582615

-
5CDS-5UTRENST00000265335ENST00000529917RAD50chr5

131895059

+BCLAF1chr6

136582615

-
5UTR-3CDSENST00000378823ENST00000031135RAD50chr5

131895059

+BCLAF1chr6

136582615

-
5UTR-3CDSENST00000378823ENST00000353331RAD50chr5

131895059

+BCLAF1chr6

136582615

-
5UTR-3CDSENST00000378823ENST00000527536RAD50chr5

131895059

+BCLAF1chr6

136582615

-
5UTR-3CDSENST00000378823ENST00000527759RAD50chr5

131895059

+BCLAF1chr6

136582615

-
5UTR-3CDSENST00000378823ENST00000530767RAD50chr5

131895059

+BCLAF1chr6

136582615

-
5UTR-3CDSENST00000378823ENST00000531224RAD50chr5

131895059

+BCLAF1chr6

136582615

-
5UTR-5UTRENST00000378823ENST00000392348RAD50chr5

131895059

+BCLAF1chr6

136582615

-
5UTR-5UTRENST00000378823ENST00000529917RAD50chr5

131895059

+BCLAF1chr6

136582615

-
In-frameENST00000265335ENST00000031135RAD50chr5

131895059

+BCLAF1chr6

136582615

-
In-frameENST00000265335ENST00000353331RAD50chr5

131895059

+BCLAF1chr6

136582615

-
In-frameENST00000265335ENST00000527536RAD50chr5

131895059

+BCLAF1chr6

136582615

-
In-frameENST00000265335ENST00000527759RAD50chr5

131895059

+BCLAF1chr6

136582615

-
In-frameENST00000265335ENST00000530767RAD50chr5

131895059

+BCLAF1chr6

136582615

-
In-frameENST00000265335ENST00000531224RAD50chr5

131895059

+BCLAF1chr6

136582615

-
intron-3CDSENST00000487596ENST00000031135RAD50chr5

131895059

+BCLAF1chr6

136582615

-
intron-3CDSENST00000487596ENST00000353331RAD50chr5

131895059

+BCLAF1chr6

136582615

-
intron-3CDSENST00000487596ENST00000527536RAD50chr5

131895059

+BCLAF1chr6

136582615

-
intron-3CDSENST00000487596ENST00000527759RAD50chr5

131895059

+BCLAF1chr6

136582615

-
intron-3CDSENST00000487596ENST00000530767RAD50chr5

131895059

+BCLAF1chr6

136582615

-
intron-3CDSENST00000487596ENST00000531224RAD50chr5

131895059

+BCLAF1chr6

136582615

-
intron-5UTRENST00000487596ENST00000392348RAD50chr5

131895059

+BCLAF1chr6

136582615

-
intron-5UTRENST00000487596ENST00000529917RAD50chr5

131895059

+BCLAF1chr6

136582615

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000265335RAD50chr5131895059+ENST00000353331BCLAF1chr6136582615-5066600360818152
ENST00000265335RAD50chr5131895059+ENST00000531224BCLAF1chr6136582615-5066600360818152
ENST00000265335RAD50chr5131895059+ENST00000527536BCLAF1chr6136582615-3343600360818152
ENST00000265335RAD50chr5131895059+ENST00000530767BCLAF1chr6136582615-2578600360818152
ENST00000265335RAD50chr5131895059+ENST00000527759BCLAF1chr6136582615-2238600360818152
ENST00000265335RAD50chr5131895059+ENST00000031135BCLAF1chr6136582615-1449600360818152

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000265335ENST00000353331RAD50chr5131895059+BCLAF1chr6136582615-0.0083367320.9916632
ENST00000265335ENST00000531224RAD50chr5131895059+BCLAF1chr6136582615-0.0083367320.9916632
ENST00000265335ENST00000527536RAD50chr5131895059+BCLAF1chr6136582615-0.0031082670.9968918
ENST00000265335ENST00000530767RAD50chr5131895059+BCLAF1chr6136582615-0.0068130760.99318695
ENST00000265335ENST00000527759RAD50chr5131895059+BCLAF1chr6136582615-0.0077018370.9922982
ENST00000265335ENST00000031135RAD50chr5131895059+BCLAF1chr6136582615-0.0090215210.9909785

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Fusion Genomic Features for RAD50-BCLAF1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

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Fusion Protein Features for RAD50-BCLAF1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr5:131895059/chr6:136582615)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneRAD50chr5:131895059chr6:136582615ENST00000265335+22536_43711313.0Nucleotide bindingATP
TgeneBCLAF1chr5:131895059chr6:136582615ENST000005307671013749_763675748.0Compositional biasNote=Poly-Ser

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneRAD50chr5:131895059chr6:136582615ENST00000265335+225228_359711313.0Coiled coilOntology_term=ECO:0000255
HgeneRAD50chr5:131895059chr6:136582615ENST00000265335+225401_598711313.0Coiled coilOntology_term=ECO:0000255
HgeneRAD50chr5:131895059chr6:136582615ENST00000265335+225635_673711313.0Coiled coilOntology_term=ECO:0000255
HgeneRAD50chr5:131895059chr6:136582615ENST00000265335+225706_734711313.0Coiled coilOntology_term=ECO:0000255
HgeneRAD50chr5:131895059chr6:136582615ENST00000265335+225789_1079711313.0Coiled coilOntology_term=ECO:0000255
HgeneRAD50chr5:131895059chr6:136582615ENST00000378823+225228_35901174.0Coiled coilOntology_term=ECO:0000255
HgeneRAD50chr5:131895059chr6:136582615ENST00000378823+225401_59801174.0Coiled coilOntology_term=ECO:0000255
HgeneRAD50chr5:131895059chr6:136582615ENST00000378823+225635_67301174.0Coiled coilOntology_term=ECO:0000255
HgeneRAD50chr5:131895059chr6:136582615ENST00000378823+225706_73401174.0Coiled coilOntology_term=ECO:0000255
HgeneRAD50chr5:131895059chr6:136582615ENST00000378823+225789_107901174.0Coiled coilOntology_term=ECO:0000255
HgeneRAD50chr5:131895059chr6:136582615ENST00000265335+2251201_1238711313.0Compositional biasNote=Ala/Asp-rich (DA-box)
HgeneRAD50chr5:131895059chr6:136582615ENST00000378823+2251201_123801174.0Compositional biasNote=Ala/Asp-rich (DA-box)
HgeneRAD50chr5:131895059chr6:136582615ENST00000265335+225635_734711313.0DomainZinc-hook
HgeneRAD50chr5:131895059chr6:136582615ENST00000378823+225635_73401174.0DomainZinc-hook
HgeneRAD50chr5:131895059chr6:136582615ENST00000378823+22536_4301174.0Nucleotide bindingATP
TgeneBCLAF1chr5:131895059chr6:136582615ENST00000353331912141_148797870.0Compositional biasNote=Poly-Ser
TgeneBCLAF1chr5:131895059chr6:136582615ENST00000353331912749_763797870.0Compositional biasNote=Poly-Ser
TgeneBCLAF1chr5:131895059chr6:136582615ENST00000392348710141_148797870.0Compositional biasNote=Poly-Ser
TgeneBCLAF1chr5:131895059chr6:136582615ENST00000392348710749_763797870.0Compositional biasNote=Poly-Ser
TgeneBCLAF1chr5:131895059chr6:136582615ENST000005277591013141_148846919.0Compositional biasNote=Poly-Ser
TgeneBCLAF1chr5:131895059chr6:136582615ENST000005277591013749_763846919.0Compositional biasNote=Poly-Ser
TgeneBCLAF1chr5:131895059chr6:136582615ENST000005307671013141_148675748.0Compositional biasNote=Poly-Ser
TgeneBCLAF1chr5:131895059chr6:136582615ENST000005312241013141_148848921.0Compositional biasNote=Poly-Ser
TgeneBCLAF1chr5:131895059chr6:136582615ENST000005312241013749_763848921.0Compositional biasNote=Poly-Ser


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Fusion Gene Sequence for RAD50-BCLAF1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>71721_71721_1_RAD50-BCLAF1_RAD50_chr5_131895059_ENST00000265335_BCLAF1_chr6_136582615_ENST00000031135_length(transcript)=1449nt_BP=600nt
CCAGGAGAGCGGCGTGGACGCGTGCGGGCCTAGAGGCCCACGTGATCCGCAGGGCGGCCGAGGCAGGAAGCTGTGAGTGCGCGGTTGCGG
GGTCGCATTGTGGCTACGGCTTTGCGTCCCCGGCGGGCAGCCCCAGGCTGGTCCCCGCCTCCGCTCTCCCCACCGGCGGGGAAAGCAGCT
GGTGTGGGAGGAAAGGCTCCATCCCCCGCCCCCTCTCTCCCGCTGTTGGCTGGCAGGATCTTTTGGCAGTCCTGTGGCCTCGCTCCCCGC
CCGGATCCTCCTGACCCTGAGATTCGCGGGTCTCACGTCCCGTGCACGCCTTGCTTCGGCCTCAGTTAAGCCTTTGTGGGCTCCAGGTCC
CTGGTGAGATTAGAAACGTTTGCAAACATGTCCCGGATCGAAAAGATGAGCATTCTGGGCGTGCGGAGTTTTGGAATAGAGGACAAAGAT
AAGCAAATTATCACTTTCTTCAGCCCCCTTACAATTTTGGTTGGACCCAATGGGGCGGGAAAGACGACCATCATTGAATGTCTAAAATAT
ATTTGTACTGGAGATTTCCCTCCTGGAACCAAAGGAAATACATTTGTACACGATCCCAAGCATGACGACAGAGATGATGGTGTGGATTAT
TGGGCCAAAAGAGGAAGAGGTCGTGGTACTTTTCAACGTGGCAGAGGGCGCTTTAACTTCAAAAAATCAGGTAGCAGTCCTAAATGGACT
CATGACAAATACCAAGGGGATGGGATTGTTGAAGATGAAGAAGAGACCATGGAAAATAATGAAGAAAAGAAGGACAGACGCAAGGAAGAA
AAGGAATAATAAATATGAAGTAAGATTACAACAGAGCAGAACTTGCACCCACCATTTTTTTTACCTGATTTTTGTTTTCAAATAAGAATG
TAAGCATTTTACTTAAATTTTACTGTTTGCAAGTAGTCTATAGAAATTTTGTTTTAAGTCTTCAAATATCTTGAGAAATAGTAGACTGTA
TGTTGAAAATTGTACTGAAATAAAGTAGAAAATTGTTACGTACCATATTTGTAACTATCAACTTTTAAAACTTTTAACGTTTTTGTTACA
TGCATTGTAATTCTGCTTTGTCTATAAGATATGGTCAAGTACAGCTCTGTGAAAGTTCTGATTCTCTTCCTTCCCTGTTTGTCAATGTTT
TATTCTGAAGTAAACGTTAGCTCTACATATAAATCCTGGAACAGAAATTGTTTATAGAGACTACACTAATTATTTTAACTGTATACATCT
GTTTAATTTGAACACACTACATCGTAGGGTGACTGATTTTTGAAGTATACCACAGACAAAAAGTTGTTACTATGGTAAACTAAGCTAGTT
TAACACTTGAGCAAATGCTTAAGAAGGAATTAAAAAAAAAAAGCTTTGCCAATAGCTAAAAAGTACAAGCTATTAAAAATCAGATTGAAA

>71721_71721_1_RAD50-BCLAF1_RAD50_chr5_131895059_ENST00000265335_BCLAF1_chr6_136582615_ENST00000031135_length(amino acids)=152AA_BP=80
MVRLETFANMSRIEKMSILGVRSFGIEDKDKQIITFFSPLTILVGPNGAGKTTIIECLKYICTGDFPPGTKGNTFVHDPKHDDRDDGVDY

--------------------------------------------------------------
>71721_71721_2_RAD50-BCLAF1_RAD50_chr5_131895059_ENST00000265335_BCLAF1_chr6_136582615_ENST00000353331_length(transcript)=5066nt_BP=600nt
CCAGGAGAGCGGCGTGGACGCGTGCGGGCCTAGAGGCCCACGTGATCCGCAGGGCGGCCGAGGCAGGAAGCTGTGAGTGCGCGGTTGCGG
GGTCGCATTGTGGCTACGGCTTTGCGTCCCCGGCGGGCAGCCCCAGGCTGGTCCCCGCCTCCGCTCTCCCCACCGGCGGGGAAAGCAGCT
GGTGTGGGAGGAAAGGCTCCATCCCCCGCCCCCTCTCTCCCGCTGTTGGCTGGCAGGATCTTTTGGCAGTCCTGTGGCCTCGCTCCCCGC
CCGGATCCTCCTGACCCTGAGATTCGCGGGTCTCACGTCCCGTGCACGCCTTGCTTCGGCCTCAGTTAAGCCTTTGTGGGCTCCAGGTCC
CTGGTGAGATTAGAAACGTTTGCAAACATGTCCCGGATCGAAAAGATGAGCATTCTGGGCGTGCGGAGTTTTGGAATAGAGGACAAAGAT
AAGCAAATTATCACTTTCTTCAGCCCCCTTACAATTTTGGTTGGACCCAATGGGGCGGGAAAGACGACCATCATTGAATGTCTAAAATAT
ATTTGTACTGGAGATTTCCCTCCTGGAACCAAAGGAAATACATTTGTACACGATCCCAAGCATGACGACAGAGATGATGGTGTGGATTAT
TGGGCCAAAAGAGGAAGAGGTCGTGGTACTTTTCAACGTGGCAGAGGGCGCTTTAACTTCAAAAAATCAGGTAGCAGTCCTAAATGGACT
CATGACAAATACCAAGGGGATGGGATTGTTGAAGATGAAGAAGAGACCATGGAAAATAATGAAGAAAAGAAGGACAGACGCAAGGAAGAA
AAGGAATAATAAATATGAAGTAAGATTACAACAGAGCAGAACTTGCACCCACCATTTTTTTTACCTGATTTTTGTTTTCAAATAAGAATG
TAAGCATTTTACTTAAATTTTACTGTTTGCAAGTAGTCTATAGAAATTTTGTTTTAAGTCTTCAAATATCTTGAGAAATAGTAGACTGTA
TGTTGAAAATTGTACTGAAATAAAGTAGAAAATTGTTACGTACCATATTTGTAACTATCAACTTTTAAAACTTTTAACGTTTTTGTTACA
TGCATTGTAATTCTGCTTTGTCTATAAGATATGGTCAAGTACAGCTCTGTGAAAGTTCTGATTCTCTTCCTTCCCTGTTTGTCAATGTTT
TATTCTGAAGTAAACGTTAGCTCTACATATAAATCCTGGAACAGAAATTGTTTATAGAGACTACACTAATTATTTTAACTGTATACATCT
GTTTAATTTGAACACACTACATCGTAGGGTGACTGATTTTTGAAGTATACCACAGACAAAAAGTTGTTACTATGGTAAACTAAGCTAGTT
TAACACTTGAGCAAATGCTTAAGAAGGAATTAAAAAAAAAAAGCTTTGCCAATAGCTAAAAAGTACAAGCTATTAAAAATCAGATTGAAA
AGTTTTGAGAAAATGTTATTTTTACTGAAAGCAAGCAGTGGCCTATAAAGAACATTCTTAGGAGCCTTTTCTATTTGCGTTCAAAACTGT
GTGTTCTCTTTCTATTCCTATTTGATAGTTTGAGTCATGGTCTTAGATATTAGCTATTTGTGAGAGGAAACTGGTTTGTAACAATACTGC
AAATAGAAACCCCATTTCTACTGAACATCCTAGTTTTAAACAGAAGAAAAACTGTAATCCTGGGGTTGGTATGTAGGAGGTCTATCCTGC
AGAATAAGTTGATACATTAGTACCTGATTTCATATCTTACATATTTATTTGAGCTGAACATTAGTTTGTAGTGTAACTATTAGTAAAAAT
AGAGAAACACAGCATACTGTTCATTAATAGTATTTTAAAAAAATTGTTTTTCAAATGTCACCAATAAAAGTTTTGGCAGGAAGCTTGTTG
CGGCATTGATCTAACCTTTTTCCCCCCCATTTCAGTTGCAGTTTTTGTAGAATGGCTTTTTCTTTTTCCTCTTAAGAGTTCTATTCTTCA
GGTAGATAATTTTTCAAATGTGAATTATCTTTTGTGTCTATATTGATAGCTCTTAAAGGAGTGAAAATCTAAAATAGTAAATTTCAATGT
TAAGTGTCTGCTTTATGGGCATATATAAAAGTAGACACATTTCATTTGTTAATTTAGTTGTGTGTGTGTGTTAAAAGGAGCTAATGCTTA
TTCTGTTAATGTAAACTTTTGAAGATCTTAAGTGTATTGCTCTTTCATCTTAAACACTTTCGAGGATTTGCAGTGCGTCTAGCACCTAGA
TTACAGCCAGGAACATTGGTTAAGAACTGTTGGAAACAAAACTAAAAGCAAACTCAACATATGTGATGTTTATGGCCCTCAGATCCTTAG
TATTGTGTGATTTTCCCCCGTTAACATGTCTTTCTAAAATTGTCTATTAAAGCAGAGGAAATACCTGCCAAAGGAAGTATGTATTGCATT
AATCAGGGCATAACTAATATTCTCCTGTTCAGAATAATACTTATTTACGTGTGAAAGCAACATGGATGTGATTCCCAACACAGAATTTTC
ATGACCCTTTTATTGTATACAAATAAATACCATAACAGTTACTTGGTTAGACATCAAATCTGTGTGCATGACTATGTGCTTATCCACTTA
AGACAATAGGTAAAAGGGGATCTGAGAAATTATGTAATAGGGAGTGGGAATAAAACTACTTAATTCCTGTGGGCAGGTTATATTTTAAGT
TCAAATGCATTGCTTTAACCTTTGGTTACTTTTATTCTGTTAAACAGAATTGAAGAAAGAGTATTATACCAGAGTGTAGTAGGCTAGGGT
GATTGTAAGAACTCTGTAATAGAATGTCATTGTGGATGTTACCTTTTTCAGATCCAAGCATATAAAAAGCCTGTATATTTTTTAAAAACA
CATCTTAACTCCACGCTTTACGATATTATAAAAGTTGAATGGTTCCTCTTGGTAAGGATATTTGCTTACAAGTGCTAGGAAATAACTCAC
TGATACCTGCGTTAACATACTTTGTTTTGCCTAGAGAGGGGCAATAAAAATGAACCAAAGGATATTTCCAGAAAGGATTAAGAAAGCTGT
TTAAGAAGGCCATGACTCTTTAGGTGTGTATGTGTACCTTTCAGCATCCTAGGAATTTTTATACTAAAAGCAAAATGTTTTTTCCAGTTA
GTCTTCTTCAAGGAATTACTATTGTTCCTTTTGTCACAGGTAAAATCAGTGTTGGGAATTATAATTTGAGAAAAATATTACCCAGTAACA
TTGAATGTAGATGGCTAAACGATTCTTACTCAGTGTGATGTATAATGATGCAACAGGGACCCTTGTAAATTGTCATACGCCAATAAAATG
TCACAAGTAATAACTGCTGTTGTTTGTTTACCTGTGTCTATTTCACACATCTTATTTCTGTGGCCTATTTTAGAATATCAGCGCATCTGT
TAGGAAGATTACTGGTGTGGTAAGGCTTGATAAATGCTTTATAAACTCCCTCAAACCTTTCTTTACTGTTTTTTTGTTTTGTCTTGTTTT
TGTTTTTGTTTTTGTTTTTGTTTTTGTTTTTGTTTTTCCCTTGTCTCCCCTGGGAAAATGGGAAATTTTACAGTTGGTAAATCTAAGCCA
AAATTATTTTGAAATAAAGGAATTCTGGATGTCCAGTTTAGTCCTCGTTTTCTTACGTTAATCTGGGACCTTATCACCCATAATATGGTG
ATTACTTCTCTTTCTAAAAACATAGTAGCTAGTAAATAAGTAAAAAGAATTGTCTTTTCATTCACTTTAAGTAAGATGTGGTATAATTCT
TACCATGTGCCATCCTGTCAGTTTTAACAAAGCATTTTCACAGAAATTTGTGTACTAAGACAAACTGACACATTTTGACTCATACAAATG
GCAAATTAGTCCTTAAAAATTCTGTGAGAGAAATAACTCTGTGTGTACATACATATGCATGTAAAGTGTTGTGTAAGATCATTGGTAGCT
TAATTATACTGGATAATTGTAATGTTATATACAAATTTCTTATATAAAAGTATGCTGCATTATTAACATTTGTTTAACTTTTCTTATTTT
TCTTTTTCTGGGTTTCAACTGGAATCCCATTGGTGGGGATGTACCTTAAGTTTCCTTGTGGAATAATAGACTTTCACATCCAGAAAGAGA
AGTTCAGAGGCCTTTCTCAATTTACAGAGTTGAAGAGGAAAGGCAAATGGAGGAATAAACTTCATTGTCATTGGGATTAATTTGGCTAGA
CTCAATCTCTTGAGCCTTAAAATGAGAAAGTAATATCCATTACATGTTTAGAGTTCTCAAATAGTTGATACTATTATTAAATGTTTCAAA
TTTTATTGGGGTAGATACTAAAAATTAGTACACTGTCCTAATGAAGTTTAAATGAACAAGTTTTACATTTCTTAGGATTCAGGAATATAT
GGAATCTAGTTGTATTTAATTGACTTGAGAGCCACAGAGATTGTGTTGATTTATGAGCTGGACTCCTATTGTTTTAGAAACATGCAGTAA
TGATTAACTTGTGTCAATGATGGTAATGAGACCAAACTTGTACATTTAATTAAGGGTACCAGTTCTTTTTATGTTACTAGACTATACCTT
GGCCTTTAAAAATGAATCTCACTGATTAAAGAGAACAGGCATTATTAGGATAGCATTCCACCACAACTAGAAACATTCAAATAATGTGTC
TTAATTGTAATCTGTATATAGGAAAATTTTTCCTATGGATATTTTTGGTGTTTTACCACAGTGAACTGATTTGTAGCACTTATGAAGTGC
AGAAGGTAATATTCTTGAAAATAGAAAAAGGTTGGGTGAGCAGGCTTTAATGCCTTTCCCCCAAGAATATACATCGAATTTTTCTTAATC
TTTTGGGGTTGGCCAGCTTCCAGATTTCATTAATAATGAGCTCTGCCTTTAATAAAAGTACATGATCATAGCTACACTGTATGTTTAGGT
GGTGTGAAATGATTTATAATCACAGCTTGAACTGTGTTTGCTTGGTACTGTCATAGTGATTACAAATTTCATGGAATGCGAAGAGCAACA

>71721_71721_2_RAD50-BCLAF1_RAD50_chr5_131895059_ENST00000265335_BCLAF1_chr6_136582615_ENST00000353331_length(amino acids)=152AA_BP=80
MVRLETFANMSRIEKMSILGVRSFGIEDKDKQIITFFSPLTILVGPNGAGKTTIIECLKYICTGDFPPGTKGNTFVHDPKHDDRDDGVDY

--------------------------------------------------------------
>71721_71721_3_RAD50-BCLAF1_RAD50_chr5_131895059_ENST00000265335_BCLAF1_chr6_136582615_ENST00000527536_length(transcript)=3343nt_BP=600nt
CCAGGAGAGCGGCGTGGACGCGTGCGGGCCTAGAGGCCCACGTGATCCGCAGGGCGGCCGAGGCAGGAAGCTGTGAGTGCGCGGTTGCGG
GGTCGCATTGTGGCTACGGCTTTGCGTCCCCGGCGGGCAGCCCCAGGCTGGTCCCCGCCTCCGCTCTCCCCACCGGCGGGGAAAGCAGCT
GGTGTGGGAGGAAAGGCTCCATCCCCCGCCCCCTCTCTCCCGCTGTTGGCTGGCAGGATCTTTTGGCAGTCCTGTGGCCTCGCTCCCCGC
CCGGATCCTCCTGACCCTGAGATTCGCGGGTCTCACGTCCCGTGCACGCCTTGCTTCGGCCTCAGTTAAGCCTTTGTGGGCTCCAGGTCC
CTGGTGAGATTAGAAACGTTTGCAAACATGTCCCGGATCGAAAAGATGAGCATTCTGGGCGTGCGGAGTTTTGGAATAGAGGACAAAGAT
AAGCAAATTATCACTTTCTTCAGCCCCCTTACAATTTTGGTTGGACCCAATGGGGCGGGAAAGACGACCATCATTGAATGTCTAAAATAT
ATTTGTACTGGAGATTTCCCTCCTGGAACCAAAGGAAATACATTTGTACACGATCCCAAGCATGACGACAGAGATGATGGTGTGGATTAT
TGGGCCAAAAGAGGAAGAGGTCGTGGTACTTTTCAACGTGGCAGAGGGCGCTTTAACTTCAAAAAATCAGGTAGCAGTCCTAAATGGACT
CATGACAAATACCAAGGGGATGGGATTGTTGAAGATGAAGAAGAGACCATGGAAAATAATGAAGAAAAGAAGGACAGACGCAAGGAAGAA
AAGGAATAATAAATATGAAGTAAGATTACAACAGAGCAGAACTTGCACCCACCATTTTTTTTACCTGATTTTTGTTTTCAAATAAGAATG
TAAGCATTTTACTTAAATTTTACTGTTTGCAAGTAGTCTATAGAAATTTTGTTTTAAGTCTTCAAATATCTTGAGAAATAGTAGACTGTA
TGTTGAAAATTGTACTGAAATAAAGTAGAAAATTGTTACGTACCATATTTGTAACTATCAACTTTTAAAACTTTTAACGTTTTTGTTACA
TGCATTGTAATTCTGCTTTGTCTATAAGATATGGTCAAGTACAGCTCTGTGAAAGTTCTGATTCTCTTCCTTCCCTGTTTGTCAATGTTT
TATTCTGAAGTAAACGTTAGCTCTACATATAAATCCTGGAACAGAAATTGTTTATAGAGACTACACTAATTATTTTAACTGTATACATCT
GTTTAATTTGAACACACTACATCGTAGGGTGACTGATTTTTGAAGTATACCACAGACAAAAAGTTGTTACTATGGTAAACTAAGCTAGTT
TAACACTTGAGCAAATGCTTAAGAAGGAATTAAAAAAAAAAAGCTTTGCCAATAGCTAAAAAGTACAAGCTATTAAAAATCAGATTGAAA
AGTTTTGAGAAAATGTTATTTTTACTGAAAGCAAGCAGTGGCCTATAAAGAACATTCTTAGGAGCCTTTTCTATTTGCGTTCAAAACTGT
GTGTTCTCTTTCTATTCCTATTTGATAGTTTGAGTCATGGTCTTAGATATTAGCTATTTGTGAGAGGAAACTGGTTTGTAACAATACTGC
AAATAGAAACCCCATTTCTACTGAACATCCTAGTTTTAAACAGAAGAAAAACTGTAATCCTGGGGTTGGTATGTAGGAGGTCTATCCTGC
AGAATAAGTTGATACATTAGTACCTGATTTCATATCTTACATATTTATTTGAGCTGAACATTAGTTTGTAGTGTAACTATTAGTAAAAAT
AGAGAAACACAGCATACTGTTCATTAATAGTATTTTAAAAAAATTGTTTTTCAAATGTCACCAATAAAAGTTTTGGCAGGAAGCTTGTTG
CGGCATTGATCTAACCTTTTTCCCCCCCATTTCAGTTGCAGTTTTTGTAGAATGGCTTTTTCTTTTTCCTCTTAAGAGTTCTATTCTTCA
GGTAGATAATTTTTCAAATGTGAATTATCTTTTGTGTCTATATTGATAGCTCTTAAAGGAGTGAAAATCTAAAATAGTAAATTTCAATGT
TAAGTGTCTGCTTTATGGGCATATATAAAAGTAGACACATTTCATTTGTTAATTTAGTTGTGTGTGTGTGTTAAAAGGAGCTAATGCTTA
TTCTGTTAATGTAAACTTTTGAAGATCTTAAGTGTATTGCTCTTTCATCTTAAACACTTTCGAGGATTTGCAGTGCGTCTAGCACCTAGA
TTACAGCCAGGAACATTGGTTAAGAACTGTTGGAAACAAAACTAAAAGCAAACTCAACATATGTGATGTTTATGGCCCTCAGATCCTTAG
TATTGTGTGATTTTCCCCCGTTAACATGTCTTTCTAAAATTGTCTATTAAAGCAGAGGAAATACCTGCCAAAGGAAGTATGTATTGCATT
AATCAGGGCATAACTAATATTCTCCTGTTCAGAATAATACTTATTTACGTGTGAAAGCAACATGGATGTGATTCCCAACACAGAATTTTC
ATGACCCTTTTATTGTATACAAATAAATACCATAACAGTTACTTGGTTAGACATCAAATCTGTGTGCATGACTATGTGCTTATCCACTTA
AGACAATAGGTAAAAGGGGATCTGAGAAATTATGTAATAGGGAGTGGGAATAAAACTACTTAATTCCTGTGGGCAGGTTATATTTTAAGT
TCAAATGCATTGCTTTAACCTTTGGTTACTTTTATTCTGTTAAACAGAATTGAAGAAAGAGTATTATACCAGAGTGTAGTAGGCTAGGGT
GATTGTAAGAACTCTGTAATAGAATGTCATTGTGGATGTTACCTTTTTCAGATCCAAGCATATAAAAAGCCTGTATATTTTTTAAAAACA
CATCTTAACTCCACGCTTTACGATATTATAAAAGTTGAATGGTTCCTCTTGGTAAGGATATTTGCTTACAAGTGCTAGGAAATAACTCAC
TGATACCTGCGTTAACATACTTTGTTTTGCCTAGAGAGGGGCAATAAAAATGAACCAAAGGATATTTCCAGAAAGGATTAAGAAAGCTGT
TTAAGAAGGCCATGACTCTTTAGGTGTGTATGTGTACCTTTCAGCATCCTAGGAATTTTTATACTAAAAGCAAAATGTTTTTTCCAGTTA
GTCTTCTTCAAGGAATTACTATTGTTCCTTTTGTCACAGGTAAAATCAGTGTTGGGAATTATAATTTGAGAAAAATATTACCCAGTAACA
TTGAATGTAGATGGCTAAACGATTCTTACTCAGTGTGATGTATAATGATGCAACAGGGACCCTTGTAAATTGTCATACGCCAATAAAATG

>71721_71721_3_RAD50-BCLAF1_RAD50_chr5_131895059_ENST00000265335_BCLAF1_chr6_136582615_ENST00000527536_length(amino acids)=152AA_BP=80
MVRLETFANMSRIEKMSILGVRSFGIEDKDKQIITFFSPLTILVGPNGAGKTTIIECLKYICTGDFPPGTKGNTFVHDPKHDDRDDGVDY

--------------------------------------------------------------
>71721_71721_4_RAD50-BCLAF1_RAD50_chr5_131895059_ENST00000265335_BCLAF1_chr6_136582615_ENST00000527759_length(transcript)=2238nt_BP=600nt
CCAGGAGAGCGGCGTGGACGCGTGCGGGCCTAGAGGCCCACGTGATCCGCAGGGCGGCCGAGGCAGGAAGCTGTGAGTGCGCGGTTGCGG
GGTCGCATTGTGGCTACGGCTTTGCGTCCCCGGCGGGCAGCCCCAGGCTGGTCCCCGCCTCCGCTCTCCCCACCGGCGGGGAAAGCAGCT
GGTGTGGGAGGAAAGGCTCCATCCCCCGCCCCCTCTCTCCCGCTGTTGGCTGGCAGGATCTTTTGGCAGTCCTGTGGCCTCGCTCCCCGC
CCGGATCCTCCTGACCCTGAGATTCGCGGGTCTCACGTCCCGTGCACGCCTTGCTTCGGCCTCAGTTAAGCCTTTGTGGGCTCCAGGTCC
CTGGTGAGATTAGAAACGTTTGCAAACATGTCCCGGATCGAAAAGATGAGCATTCTGGGCGTGCGGAGTTTTGGAATAGAGGACAAAGAT
AAGCAAATTATCACTTTCTTCAGCCCCCTTACAATTTTGGTTGGACCCAATGGGGCGGGAAAGACGACCATCATTGAATGTCTAAAATAT
ATTTGTACTGGAGATTTCCCTCCTGGAACCAAAGGAAATACATTTGTACACGATCCCAAGCATGACGACAGAGATGATGGTGTGGATTAT
TGGGCCAAAAGAGGAAGAGGTCGTGGTACTTTTCAACGTGGCAGAGGGCGCTTTAACTTCAAAAAATCAGGTAGCAGTCCTAAATGGACT
CATGACAAATACCAAGGGGATGGGATTGTTGAAGATGAAGAAGAGACCATGGAAAATAATGAAGAAAAGAAGGACAGACGCAAGGAAGAA
AAGGAATAATAAATATGAAGTAAGATTACAACAGAGCAGAACTTGCACCCACCATTTTTTTTACCTGATTTTTGTTTTCAAATAAGAATG
TAAGCATTTTACTTAAATTTTACTGTTTGCAAGTAGTCTATAGAAATTTTGTTTTAAGTCTTCAAATATCTTGAGAAATAGTAGACTGTA
TGTTGAAAATTGTACTGAAATAAAGTAGAAAATTGTTACGTACCATATTTGTAACTATCAACTTTTAAAACTTTTAACGTTTTTGTTACA
TGCATTGTAATTCTGCTTTGTCTATAAGATATGGTCAAGTACAGCTCTGTGAAAGTTCTGATTCTCTTCCTTCCCTGTTTGTCAATGTTT
TATTCTGAAGTAAACGTTAGCTCTACATATAAATCCTGGAACAGAAATTGTTTATAGAGACTACACTAATTATTTTAACTGTATACATCT
GTTTAATTTGAACACACTACATCGTAGGGTGACTGATTTTTGAAGTATACCACAGACAAAAAGTTGTTACTATGGTAAACTAAGCTAGTT
TAACACTTGAGCAAATGCTTAAGAAGGAATTAAAAAAAAAAAGCTTTGCCAATAGCTAAAAAGTACAAGCTATTAAAAATCAGATTGAAA
AGTTTTGAGAAAATGTTATTTTTACTGAAAGCAAGCAGTGGCCTATAAAGAACATTCTTAGGAGCCTTTTCTATTTGCGTTCAAAACTGT
GTGTTCTCTTTCTATTCCTATTTGATAGTTTGAGTCATGGTCTTAGATATTAGCTATTTGTGAGAGGAAACTGGTTTGTAACAATACTGC
AAATAGAAACCCCATTTCTACTGAACATCCTAGTTTTAAACAGAAGAAAAACTGTAATCCTGGGGTTGGTATGTAGGAGGTCTATCCTGC
AGAATAAGTTGATACATTAGTACCTGATTTCATATCTTACATATTTATTTGAGCTGAACATTAGTTTGTAGTGTAACTATTAGTAAAAAT
AGAGAAACACAGCATACTGTTCATTAATAGTATTTTAAAAAAATTGTTTTTCAAATGTCACCAATAAAAGTTTTGGCAGGAAGCTTGTTG
CGGCATTGATCTAACCTTTTTCCCCCCCATTTCAGTTGCAGTTTTTGTAGAATGGCTTTTTCTTTTTCCTCTTAAGAGTTCTATTCTTCA
GGTAGATAATTTTTCAAATGTGAATTATCTTTTGTGTCTATATTGATAGCTCTTAAAGGAGTGAAAATCTAAAATAGTAAATTTCAATGT
TAAGTGTCTGCTTTATGGGCATATATAAAAGTAGACACATTTCATTTGTTAATTTAGTTGTGTGTGTGTGTTAAAAGGAGCTAATGCTTA

>71721_71721_4_RAD50-BCLAF1_RAD50_chr5_131895059_ENST00000265335_BCLAF1_chr6_136582615_ENST00000527759_length(amino acids)=152AA_BP=80
MVRLETFANMSRIEKMSILGVRSFGIEDKDKQIITFFSPLTILVGPNGAGKTTIIECLKYICTGDFPPGTKGNTFVHDPKHDDRDDGVDY

--------------------------------------------------------------
>71721_71721_5_RAD50-BCLAF1_RAD50_chr5_131895059_ENST00000265335_BCLAF1_chr6_136582615_ENST00000530767_length(transcript)=2578nt_BP=600nt
CCAGGAGAGCGGCGTGGACGCGTGCGGGCCTAGAGGCCCACGTGATCCGCAGGGCGGCCGAGGCAGGAAGCTGTGAGTGCGCGGTTGCGG
GGTCGCATTGTGGCTACGGCTTTGCGTCCCCGGCGGGCAGCCCCAGGCTGGTCCCCGCCTCCGCTCTCCCCACCGGCGGGGAAAGCAGCT
GGTGTGGGAGGAAAGGCTCCATCCCCCGCCCCCTCTCTCCCGCTGTTGGCTGGCAGGATCTTTTGGCAGTCCTGTGGCCTCGCTCCCCGC
CCGGATCCTCCTGACCCTGAGATTCGCGGGTCTCACGTCCCGTGCACGCCTTGCTTCGGCCTCAGTTAAGCCTTTGTGGGCTCCAGGTCC
CTGGTGAGATTAGAAACGTTTGCAAACATGTCCCGGATCGAAAAGATGAGCATTCTGGGCGTGCGGAGTTTTGGAATAGAGGACAAAGAT
AAGCAAATTATCACTTTCTTCAGCCCCCTTACAATTTTGGTTGGACCCAATGGGGCGGGAAAGACGACCATCATTGAATGTCTAAAATAT
ATTTGTACTGGAGATTTCCCTCCTGGAACCAAAGGAAATACATTTGTACACGATCCCAAGCATGACGACAGAGATGATGGTGTGGATTAT
TGGGCCAAAAGAGGAAGAGGTCGTGGTACTTTTCAACGTGGCAGAGGGCGCTTTAACTTCAAAAAATCAGGTAGCAGTCCTAAATGGACT
CATGACAAATACCAAGGGGATGGGATTGTTGAAGATGAAGAAGAGACCATGGAAAATAATGAAGAAAAGAAGGACAGACGCAAGGAAGAA
AAGGAATAATAAATATGAAGTAAGATTACAACAGAGCAGAACTTGCACCCACCATTTTTTTTACCTGATTTTTGTTTTCAAATAAGAATG
TAAGCATTTTACTTAAATTTTACTGTTTGCAAGTAGTCTATAGAAATTTTGTTTTAAGTCTTCAAATATCTTGAGAAATAGTAGACTGTA
TGTTGAAAATTGTACTGAAATAAAGTAGAAAATTGTTACGTACCATATTTGTAACTATCAACTTTTAAAACTTTTAACGTTTTTGTTACA
TGCATTGTAATTCTGCTTTGTCTATAAGATATGGTCAAGTACAGCTCTGTGAAAGTTCTGATTCTCTTCCTTCCCTGTTTGTCAATGTTT
TATTCTGAAGTAAACGTTAGCTCTACATATAAATCCTGGAACAGAAATTGTTTATAGAGACTACACTAATTATTTTAACTGTATACATCT
GTTTAATTTGAACACACTACATCGTAGGGTGACTGATTTTTGAAGTATACCACAGACAAAAAGTTGTTACTATGGTAAACTAAGCTAGTT
TAACACTTGAGCAAATGCTTAAGAAGGAATTAAAAAAAAAAAGCTTTGCCAATAGCTAAAAAGTACAAGCTATTAAAAATCAGATTGAAA
AGTTTTGAGAAAATGTTATTTTTACTGAAAGCAAGCAGTGGCCTATAAAGAACATTCTTAGGAGCCTTTTCTATTTGCGTTCAAAACTGT
GTGTTCTCTTTCTATTCCTATTTGATAGTTTGAGTCATGGTCTTAGATATTAGCTATTTGTGAGAGGAAACTGGTTTGTAACAATACTGC
AAATAGAAACCCCATTTCTACTGAACATCCTAGTTTTAAACAGAAGAAAAACTGTAATCCTGGGGTTGGTATGTAGGAGGTCTATCCTGC
AGAATAAGTTGATACATTAGTACCTGATTTCATATCTTACATATTTATTTGAGCTGAACATTAGTTTGTAGTGTAACTATTAGTAAAAAT
AGAGAAACACAGCATACTGTTCATTAATAGTATTTTAAAAAAATTGTTTTTCAAATGTCACCAATAAAAGTTTTGGCAGGAAGCTTGTTG
CGGCATTGATCTAACCTTTTTCCCCCCCATTTCAGTTGCAGTTTTTGTAGAATGGCTTTTTCTTTTTCCTCTTAAGAGTTCTATTCTTCA
GGTAGATAATTTTTCAAATGTGAATTATCTTTTGTGTCTATATTGATAGCTCTTAAAGGAGTGAAAATCTAAAATAGTAAATTTCAATGT
TAAGTGTCTGCTTTATGGGCATATATAAAAGTAGACACATTTCATTTGTTAATTTAGTTGTGTGTGTGTGTTAAAAGGAGCTAATGCTTA
TTCTGTTAATGTAAACTTTTGAAGATCTTAAGTGTATTGCTCTTTCATCTTAAACACTTTCGAGGATTTGCAGTGCGTCTAGCACCTAGA
TTACAGCCAGGAACATTGGTTAAGAACTGTTGGAAACAAAACTAAAAGCAAACTCAACATATGTGATGTTTATGGCCCTCAGATCCTTAG
TATTGTGTGATTTTCCCCCGTTAACATGTCTTTCTAAAATTGTCTATTAAAGCAGAGGAAATACCTGCCAAAGGAAGTATGTATTGCATT
AATCAGGGCATAACTAATATTCTCCTGTTCAGAATAATACTTATTTACGTGTGAAAGCAACATGGATGTGATTCCCAACACAGAATTTTC

>71721_71721_5_RAD50-BCLAF1_RAD50_chr5_131895059_ENST00000265335_BCLAF1_chr6_136582615_ENST00000530767_length(amino acids)=152AA_BP=80
MVRLETFANMSRIEKMSILGVRSFGIEDKDKQIITFFSPLTILVGPNGAGKTTIIECLKYICTGDFPPGTKGNTFVHDPKHDDRDDGVDY

--------------------------------------------------------------
>71721_71721_6_RAD50-BCLAF1_RAD50_chr5_131895059_ENST00000265335_BCLAF1_chr6_136582615_ENST00000531224_length(transcript)=5066nt_BP=600nt
CCAGGAGAGCGGCGTGGACGCGTGCGGGCCTAGAGGCCCACGTGATCCGCAGGGCGGCCGAGGCAGGAAGCTGTGAGTGCGCGGTTGCGG
GGTCGCATTGTGGCTACGGCTTTGCGTCCCCGGCGGGCAGCCCCAGGCTGGTCCCCGCCTCCGCTCTCCCCACCGGCGGGGAAAGCAGCT
GGTGTGGGAGGAAAGGCTCCATCCCCCGCCCCCTCTCTCCCGCTGTTGGCTGGCAGGATCTTTTGGCAGTCCTGTGGCCTCGCTCCCCGC
CCGGATCCTCCTGACCCTGAGATTCGCGGGTCTCACGTCCCGTGCACGCCTTGCTTCGGCCTCAGTTAAGCCTTTGTGGGCTCCAGGTCC
CTGGTGAGATTAGAAACGTTTGCAAACATGTCCCGGATCGAAAAGATGAGCATTCTGGGCGTGCGGAGTTTTGGAATAGAGGACAAAGAT
AAGCAAATTATCACTTTCTTCAGCCCCCTTACAATTTTGGTTGGACCCAATGGGGCGGGAAAGACGACCATCATTGAATGTCTAAAATAT
ATTTGTACTGGAGATTTCCCTCCTGGAACCAAAGGAAATACATTTGTACACGATCCCAAGCATGACGACAGAGATGATGGTGTGGATTAT
TGGGCCAAAAGAGGAAGAGGTCGTGGTACTTTTCAACGTGGCAGAGGGCGCTTTAACTTCAAAAAATCAGGTAGCAGTCCTAAATGGACT
CATGACAAATACCAAGGGGATGGGATTGTTGAAGATGAAGAAGAGACCATGGAAAATAATGAAGAAAAGAAGGACAGACGCAAGGAAGAA
AAGGAATAATAAATATGAAGTAAGATTACAACAGAGCAGAACTTGCACCCACCATTTTTTTTACCTGATTTTTGTTTTCAAATAAGAATG
TAAGCATTTTACTTAAATTTTACTGTTTGCAAGTAGTCTATAGAAATTTTGTTTTAAGTCTTCAAATATCTTGAGAAATAGTAGACTGTA
TGTTGAAAATTGTACTGAAATAAAGTAGAAAATTGTTACGTACCATATTTGTAACTATCAACTTTTAAAACTTTTAACGTTTTTGTTACA
TGCATTGTAATTCTGCTTTGTCTATAAGATATGGTCAAGTACAGCTCTGTGAAAGTTCTGATTCTCTTCCTTCCCTGTTTGTCAATGTTT
TATTCTGAAGTAAACGTTAGCTCTACATATAAATCCTGGAACAGAAATTGTTTATAGAGACTACACTAATTATTTTAACTGTATACATCT
GTTTAATTTGAACACACTACATCGTAGGGTGACTGATTTTTGAAGTATACCACAGACAAAAAGTTGTTACTATGGTAAACTAAGCTAGTT
TAACACTTGAGCAAATGCTTAAGAAGGAATTAAAAAAAAAAAGCTTTGCCAATAGCTAAAAAGTACAAGCTATTAAAAATCAGATTGAAA
AGTTTTGAGAAAATGTTATTTTTACTGAAAGCAAGCAGTGGCCTATAAAGAACATTCTTAGGAGCCTTTTCTATTTGCGTTCAAAACTGT
GTGTTCTCTTTCTATTCCTATTTGATAGTTTGAGTCATGGTCTTAGATATTAGCTATTTGTGAGAGGAAACTGGTTTGTAACAATACTGC
AAATAGAAACCCCATTTCTACTGAACATCCTAGTTTTAAACAGAAGAAAAACTGTAATCCTGGGGTTGGTATGTAGGAGGTCTATCCTGC
AGAATAAGTTGATACATTAGTACCTGATTTCATATCTTACATATTTATTTGAGCTGAACATTAGTTTGTAGTGTAACTATTAGTAAAAAT
AGAGAAACACAGCATACTGTTCATTAATAGTATTTTAAAAAAATTGTTTTTCAAATGTCACCAATAAAAGTTTTGGCAGGAAGCTTGTTG
CGGCATTGATCTAACCTTTTTCCCCCCCATTTCAGTTGCAGTTTTTGTAGAATGGCTTTTTCTTTTTCCTCTTAAGAGTTCTATTCTTCA
GGTAGATAATTTTTCAAATGTGAATTATCTTTTGTGTCTATATTGATAGCTCTTAAAGGAGTGAAAATCTAAAATAGTAAATTTCAATGT
TAAGTGTCTGCTTTATGGGCATATATAAAAGTAGACACATTTCATTTGTTAATTTAGTTGTGTGTGTGTGTTAAAAGGAGCTAATGCTTA
TTCTGTTAATGTAAACTTTTGAAGATCTTAAGTGTATTGCTCTTTCATCTTAAACACTTTCGAGGATTTGCAGTGCGTCTAGCACCTAGA
TTACAGCCAGGAACATTGGTTAAGAACTGTTGGAAACAAAACTAAAAGCAAACTCAACATATGTGATGTTTATGGCCCTCAGATCCTTAG
TATTGTGTGATTTTCCCCCGTTAACATGTCTTTCTAAAATTGTCTATTAAAGCAGAGGAAATACCTGCCAAAGGAAGTATGTATTGCATT
AATCAGGGCATAACTAATATTCTCCTGTTCAGAATAATACTTATTTACGTGTGAAAGCAACATGGATGTGATTCCCAACACAGAATTTTC
ATGACCCTTTTATTGTATACAAATAAATACCATAACAGTTACTTGGTTAGACATCAAATCTGTGTGCATGACTATGTGCTTATCCACTTA
AGACAATAGGTAAAAGGGGATCTGAGAAATTATGTAATAGGGAGTGGGAATAAAACTACTTAATTCCTGTGGGCAGGTTATATTTTAAGT
TCAAATGCATTGCTTTAACCTTTGGTTACTTTTATTCTGTTAAACAGAATTGAAGAAAGAGTATTATACCAGAGTGTAGTAGGCTAGGGT
GATTGTAAGAACTCTGTAATAGAATGTCATTGTGGATGTTACCTTTTTCAGATCCAAGCATATAAAAAGCCTGTATATTTTTTAAAAACA
CATCTTAACTCCACGCTTTACGATATTATAAAAGTTGAATGGTTCCTCTTGGTAAGGATATTTGCTTACAAGTGCTAGGAAATAACTCAC
TGATACCTGCGTTAACATACTTTGTTTTGCCTAGAGAGGGGCAATAAAAATGAACCAAAGGATATTTCCAGAAAGGATTAAGAAAGCTGT
TTAAGAAGGCCATGACTCTTTAGGTGTGTATGTGTACCTTTCAGCATCCTAGGAATTTTTATACTAAAAGCAAAATGTTTTTTCCAGTTA
GTCTTCTTCAAGGAATTACTATTGTTCCTTTTGTCACAGGTAAAATCAGTGTTGGGAATTATAATTTGAGAAAAATATTACCCAGTAACA
TTGAATGTAGATGGCTAAACGATTCTTACTCAGTGTGATGTATAATGATGCAACAGGGACCCTTGTAAATTGTCATACGCCAATAAAATG
TCACAAGTAATAACTGCTGTTGTTTGTTTACCTGTGTCTATTTCACACATCTTATTTCTGTGGCCTATTTTAGAATATCAGCGCATCTGT
TAGGAAGATTACTGGTGTGGTAAGGCTTGATAAATGCTTTATAAACTCCCTCAAACCTTTCTTTACTGTTTTTTTGTTTTGTCTTGTTTT
TGTTTTTGTTTTTGTTTTTGTTTTTGTTTTTGTTTTTCCCTTGTCTCCCCTGGGAAAATGGGAAATTTTACAGTTGGTAAATCTAAGCCA
AAATTATTTTGAAATAAAGGAATTCTGGATGTCCAGTTTAGTCCTCGTTTTCTTACGTTAATCTGGGACCTTATCACCCATAATATGGTG
ATTACTTCTCTTTCTAAAAACATAGTAGCTAGTAAATAAGTAAAAAGAATTGTCTTTTCATTCACTTTAAGTAAGATGTGGTATAATTCT
TACCATGTGCCATCCTGTCAGTTTTAACAAAGCATTTTCACAGAAATTTGTGTACTAAGACAAACTGACACATTTTGACTCATACAAATG
GCAAATTAGTCCTTAAAAATTCTGTGAGAGAAATAACTCTGTGTGTACATACATATGCATGTAAAGTGTTGTGTAAGATCATTGGTAGCT
TAATTATACTGGATAATTGTAATGTTATATACAAATTTCTTATATAAAAGTATGCTGCATTATTAACATTTGTTTAACTTTTCTTATTTT
TCTTTTTCTGGGTTTCAACTGGAATCCCATTGGTGGGGATGTACCTTAAGTTTCCTTGTGGAATAATAGACTTTCACATCCAGAAAGAGA
AGTTCAGAGGCCTTTCTCAATTTACAGAGTTGAAGAGGAAAGGCAAATGGAGGAATAAACTTCATTGTCATTGGGATTAATTTGGCTAGA
CTCAATCTCTTGAGCCTTAAAATGAGAAAGTAATATCCATTACATGTTTAGAGTTCTCAAATAGTTGATACTATTATTAAATGTTTCAAA
TTTTATTGGGGTAGATACTAAAAATTAGTACACTGTCCTAATGAAGTTTAAATGAACAAGTTTTACATTTCTTAGGATTCAGGAATATAT
GGAATCTAGTTGTATTTAATTGACTTGAGAGCCACAGAGATTGTGTTGATTTATGAGCTGGACTCCTATTGTTTTAGAAACATGCAGTAA
TGATTAACTTGTGTCAATGATGGTAATGAGACCAAACTTGTACATTTAATTAAGGGTACCAGTTCTTTTTATGTTACTAGACTATACCTT
GGCCTTTAAAAATGAATCTCACTGATTAAAGAGAACAGGCATTATTAGGATAGCATTCCACCACAACTAGAAACATTCAAATAATGTGTC
TTAATTGTAATCTGTATATAGGAAAATTTTTCCTATGGATATTTTTGGTGTTTTACCACAGTGAACTGATTTGTAGCACTTATGAAGTGC
AGAAGGTAATATTCTTGAAAATAGAAAAAGGTTGGGTGAGCAGGCTTTAATGCCTTTCCCCCAAGAATATACATCGAATTTTTCTTAATC
TTTTGGGGTTGGCCAGCTTCCAGATTTCATTAATAATGAGCTCTGCCTTTAATAAAAGTACATGATCATAGCTACACTGTATGTTTAGGT
GGTGTGAAATGATTTATAATCACAGCTTGAACTGTGTTTGCTTGGTACTGTCATAGTGATTACAAATTTCATGGAATGCGAAGAGCAACA

>71721_71721_6_RAD50-BCLAF1_RAD50_chr5_131895059_ENST00000265335_BCLAF1_chr6_136582615_ENST00000531224_length(amino acids)=152AA_BP=80
MVRLETFANMSRIEKMSILGVRSFGIEDKDKQIITFFSPLTILVGPNGAGKTTIIECLKYICTGDFPPGTKGNTFVHDPKHDDRDDGVDY

--------------------------------------------------------------

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Fusion Gene PPI Analysis for RAD50-BCLAF1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for RAD50-BCLAF1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for RAD50-BCLAF1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneRAD50C0346153Breast Cancer, Familial4CLINGEN
HgeneRAD50C0677776Hereditary Breast and Ovarian Cancer Syndrome2ORPHANET
HgeneRAD50C0004096Asthma1CTD_human
HgeneRAD50C2751318Nijmegen Breakage Syndrome-Like Disorder1CTD_human;GENOMICS_ENGLAND;ORPHANET
TgeneC0149925Small cell carcinoma of lung1CTD_human