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![]() | Fusion Gene Summary |
![]() | Fusion Gene ORF analysis |
![]() | Fusion Genomic Features |
![]() | Fusion Protein Features |
![]() | Fusion Gene Sequence |
![]() | Fusion Gene PPI analysis |
![]() | Related Drugs |
![]() | Related Diseases |
Fusion gene:CDH13-LIPF (FusionGDB2 ID:HG1012TG8513) |
Fusion Gene Summary for CDH13-LIPF |
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Fusion gene information | Fusion gene name: CDH13-LIPF | Fusion gene ID: hg1012tg8513 | Hgene | Tgene | Gene symbol | CDH13 | LIPF | Gene ID | 1012 | 8513 |
Gene name | cadherin 13 | lipase F, gastric type | |
Synonyms | CDHH|P105 | GL|HGL|HLAL | |
Cytomap | ('CDH13')('LIPF') 16q23.3 | 10q23.31 | |
Type of gene | protein-coding | protein-coding | |
Description | cadherin-13H-cadherin (heart)T-cadT-cadherincadherin 13, H-cadherin (heart)heart cadherin | gastric triacylglycerol lipasegastric lipaselipase, gastric | |
Modification date | 20200315 | 20200313 | |
UniProtAcc | . | P07098 | |
Ensembl transtripts involved in fusion gene | ENST00000268613, ENST00000428848, ENST00000431540, ENST00000446376, ENST00000565636, ENST00000566620, ENST00000567445, ENST00000569454, | ||
Fusion gene scores | * DoF score | 15 X 15 X 4=900 | 17 X 18 X 7=2142 |
# samples | 17 | 18 | |
** MAII score | log2(17/900*10)=-2.40439025507934 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(18/2142*10)=-3.57288966842058 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: CDH13 [Title/Abstract] AND LIPF [Title/Abstract] AND fusion [Title/Abstract] | ||
Most frequent breakpoint | CDH13(83121276)-LIPF(90438563), # samples:1 | ||
Anticipated loss of major functional domain due to fusion event. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | CDH13 | GO:0002040 | sprouting angiogenesis | 16873731 |
Hgene | CDH13 | GO:0007156 | homophilic cell adhesion via plasma membrane adhesion molecules | 10601632 |
Hgene | CDH13 | GO:0007162 | negative regulation of cell adhesion | 14729458 |
Hgene | CDH13 | GO:0008285 | negative regulation of cell proliferation | 10737605 |
Hgene | CDH13 | GO:0016339 | calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules | 10601632 |
Hgene | CDH13 | GO:0030032 | lamellipodium assembly | 15703273 |
Hgene | CDH13 | GO:0030335 | positive regulation of cell migration | 14729458 |
Hgene | CDH13 | GO:0043542 | endothelial cell migration | 14729458 |
Hgene | CDH13 | GO:0043616 | keratinocyte proliferation | 15816843 |
Hgene | CDH13 | GO:0050850 | positive regulation of calcium-mediated signaling | 16013438 |
Hgene | CDH13 | GO:0050927 | positive regulation of positive chemotaxis | 16013438 |
Hgene | CDH13 | GO:0055096 | low-density lipoprotein particle mediated signaling | 16013438 |
![]() * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
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Fusion Gene ORF analysis for CDH13-LIPF |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
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Fusion Genomic Features for CDH13-LIPF |
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Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
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Fusion Protein Features for CDH13-LIPF |
![]() Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:83121276/:90438563) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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Hgene | Tgene |
. | LIPF |
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. | FUNCTION: Catalyzes the hydrolysis of triacylglycerols to yield free fatty acids, diacylglycerol, monoacylglycerol, and glycerol (PubMed:2243091, PubMed:10358049). Shows a preferential hydrolysis at the sn-3 position of triacylglycerol (PubMed:2243091). {ECO:0000269|PubMed:10358049, ECO:0000269|PubMed:2243091}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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Fusion Gene Sequence for CDH13-LIPF |
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Fusion Gene PPI Analysis for CDH13-LIPF |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for CDH13-LIPF |
![]() (DrugBank Version 5.1.8 2021-05-08) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Tgene | LIPF | P07098 | DB01083 | Orlistat | Inhibitor | Small molecule | Approved|Investigational |
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Related Diseases for CDH13-LIPF |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | CDH13 | C0001973 | Alcoholic Intoxication, Chronic | 3 | PSYGENET |
Hgene | CDH13 | C2239176 | Liver carcinoma | 3 | CTD_human |
Hgene | CDH13 | C0033578 | Prostatic Neoplasms | 2 | CTD_human |
Hgene | CDH13 | C0376358 | Malignant neoplasm of prostate | 2 | CTD_human |
Hgene | CDH13 | C0004763 | Barrett Esophagus | 1 | CTD_human |
Hgene | CDH13 | C0007131 | Non-Small Cell Lung Carcinoma | 1 | CTD_human |
Hgene | CDH13 | C0011570 | Mental Depression | 1 | PSYGENET |
Hgene | CDH13 | C0011581 | Depressive disorder | 1 | PSYGENET |
Hgene | CDH13 | C0013146 | Drug abuse | 1 | CTD_human |
Hgene | CDH13 | C0013170 | Drug habituation | 1 | CTD_human |
Hgene | CDH13 | C0013222 | Drug Use Disorders | 1 | CTD_human |
Hgene | CDH13 | C0014859 | Esophageal Neoplasms | 1 | CTD_human |
Hgene | CDH13 | C0024121 | Lung Neoplasms | 1 | CTD_human |
Hgene | CDH13 | C0029231 | Organic Mental Disorders, Substance-Induced | 1 | CTD_human |
Hgene | CDH13 | C0038580 | Substance Dependence | 1 | CTD_human |
Hgene | CDH13 | C0038586 | Substance Use Disorders | 1 | CTD_human |
Hgene | CDH13 | C0236733 | Amphetamine-Related Disorders | 1 | CTD_human |
Hgene | CDH13 | C0236804 | Amphetamine Addiction | 1 | CTD_human |
Hgene | CDH13 | C0236807 | Amphetamine Abuse | 1 | CTD_human |
Hgene | CDH13 | C0236969 | Substance-Related Disorders | 1 | CTD_human |
Hgene | CDH13 | C0242379 | Malignant neoplasm of lung | 1 | CTD_human |
Hgene | CDH13 | C0546837 | Malignant neoplasm of esophagus | 1 | CTD_human |
Hgene | CDH13 | C0740858 | Substance abuse problem | 1 | CTD_human |
Hgene | CDH13 | C1258085 | Barrett Epithelium | 1 | CTD_human |
Hgene | CDH13 | C1510472 | Drug Dependence | 1 | CTD_human |
Hgene | CDH13 | C4316881 | Prescription Drug Abuse | 1 | CTD_human |