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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:BCAP31-SYNJ2BP (FusionGDB2 ID:HG10134TG55333)

Fusion Gene Summary for BCAP31-SYNJ2BP

check button Fusion gene summary
Fusion gene informationFusion gene name: BCAP31-SYNJ2BP
Fusion gene ID: hg10134tg55333
HgeneTgene
Gene symbol

BCAP31

SYNJ2BP

Gene ID

10134

55333

Gene nameB cell receptor associated protein 31synaptojanin 2 binding protein
Synonyms6C6-AG|BAP31|CDM|DDCH|DXS1357EARIP2|OMP25
Cytomap('BCAP31')('SYNJ2BP')

Xq28

14q24.2

Type of geneprotein-codingprotein-coding
DescriptionB-cell receptor-associated protein 316C6-AG tumor-associated antigenBCR-associated protein Bap31p28 Bap31synaptojanin-2-binding proteinactivin receptor interacting protein 5mitochondrial outer membrane protein 25
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000345046, ENST00000441714, 
ENST00000458587, ENST00000468947, 
Fusion gene scores* DoF score6 X 8 X 4=1922 X 2 X 2=8
# samples 92
** MAII scorelog2(9/192*10)=-1.09310940439148
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(2/8*10)=1.32192809488736
Context

PubMed: BCAP31 [Title/Abstract] AND SYNJ2BP [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointBCAP31(152969414)-SYNJ2BP(70842488), # samples:1
Anticipated loss of major functional domain due to fusion event.BCAP31-SYNJ2BP seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
BCAP31-SYNJ2BP seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneBCAP31

GO:1904154

positive regulation of retrograde protein transport, ER to cytosol

18555783

TgeneSYNJ2BP

GO:0070373

negative regulation of ERK1 and ERK2 cascade

24025447


check buttonFusion gene breakpoints across BCAP31 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across SYNJ2BP (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-OL-A97C-01ABCAP31chrX

152969414

-SYNJ2BPchr14

70842488

-


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Fusion Gene ORF analysis for BCAP31-SYNJ2BP

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000345046ENST00000554216BCAP31chrX

152969414

-SYNJ2BPchr14

70842488

-
5CDS-5UTRENST00000441714ENST00000554216BCAP31chrX

152969414

-SYNJ2BPchr14

70842488

-
5CDS-5UTRENST00000458587ENST00000554216BCAP31chrX

152969414

-SYNJ2BPchr14

70842488

-
Frame-shiftENST00000345046ENST00000256366BCAP31chrX

152969414

-SYNJ2BPchr14

70842488

-
In-frameENST00000441714ENST00000256366BCAP31chrX

152969414

-SYNJ2BPchr14

70842488

-
In-frameENST00000458587ENST00000256366BCAP31chrX

152969414

-SYNJ2BPchr14

70842488

-
intron-3CDSENST00000468947ENST00000256366BCAP31chrX

152969414

-SYNJ2BPchr14

70842488

-
intron-5UTRENST00000468947ENST00000554216BCAP31chrX

152969414

-SYNJ2BPchr14

70842488

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000441714BCAP31chrX152969414-ENST00000256366SYNJ2BPchr1470842488-2501704227940237
ENST00000458587BCAP31chrX152969414-ENST00000256366SYNJ2BPchr1470842488-290511083911344317

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000441714ENST00000256366BCAP31chrX152969414-SYNJ2BPchr1470842488-0.0035494610.99645054
ENST00000458587ENST00000256366BCAP31chrX152969414-SYNJ2BPchr1470842488-0.0027107850.9972892

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Fusion Genomic Features for BCAP31-SYNJ2BP


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

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Fusion Protein Features for BCAP31-SYNJ2BP


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chrX:152969414/chr14:70842488)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneBCAP31chrX:152969414chr14:70842488ENST00000345046-5828_43159247.0Topological domainCytoplasmic
HgeneBCAP31chrX:152969414chr14:70842488ENST00000345046-582_6159247.0Topological domainLumenal
HgeneBCAP31chrX:152969414chr14:70842488ENST00000345046-5865_102159247.0Topological domainLumenal
HgeneBCAP31chrX:152969414chr14:70842488ENST00000441714-5828_43159247.0Topological domainCytoplasmic
HgeneBCAP31chrX:152969414chr14:70842488ENST00000441714-582_6159247.0Topological domainLumenal
HgeneBCAP31chrX:152969414chr14:70842488ENST00000441714-5865_102159247.0Topological domainLumenal
HgeneBCAP31chrX:152969414chr14:70842488ENST00000458587-5828_43226314.0Topological domainCytoplasmic
HgeneBCAP31chrX:152969414chr14:70842488ENST00000458587-582_6226314.0Topological domainLumenal
HgeneBCAP31chrX:152969414chr14:70842488ENST00000458587-5865_102226314.0Topological domainLumenal
HgeneBCAP31chrX:152969414chr14:70842488ENST00000345046-58103_123159247.0TransmembraneHelical
HgeneBCAP31chrX:152969414chr14:70842488ENST00000345046-5844_64159247.0TransmembraneHelical
HgeneBCAP31chrX:152969414chr14:70842488ENST00000345046-587_27159247.0TransmembraneHelical
HgeneBCAP31chrX:152969414chr14:70842488ENST00000441714-58103_123159247.0TransmembraneHelical
HgeneBCAP31chrX:152969414chr14:70842488ENST00000441714-5844_64159247.0TransmembraneHelical
HgeneBCAP31chrX:152969414chr14:70842488ENST00000441714-587_27159247.0TransmembraneHelical
HgeneBCAP31chrX:152969414chr14:70842488ENST00000458587-58103_123226314.0TransmembraneHelical
HgeneBCAP31chrX:152969414chr14:70842488ENST00000458587-5844_64226314.0TransmembraneHelical
HgeneBCAP31chrX:152969414chr14:70842488ENST00000458587-587_27226314.0TransmembraneHelical
TgeneSYNJ2BPchrX:152969414chr14:70842488ENST0000025636614139_14567146.0Topological domainMitochondrial intermembrane
TgeneSYNJ2BPchrX:152969414chr14:70842488ENST0000025636614118_13867146.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneBCAP31chrX:152969414chr14:70842488ENST00000345046-58165_237159247.0Coiled coilOntology_term=ECO:0000269
HgeneBCAP31chrX:152969414chr14:70842488ENST00000441714-58165_237159247.0Coiled coilOntology_term=ECO:0000269
HgeneBCAP31chrX:152969414chr14:70842488ENST00000458587-58165_237226314.0Coiled coilOntology_term=ECO:0000269
HgeneBCAP31chrX:152969414chr14:70842488ENST00000345046-58243_246159247.0MotifNote=Di-lysine motif
HgeneBCAP31chrX:152969414chr14:70842488ENST00000441714-58243_246159247.0MotifNote=Di-lysine motif
HgeneBCAP31chrX:152969414chr14:70842488ENST00000458587-58243_246226314.0MotifNote=Di-lysine motif
HgeneBCAP31chrX:152969414chr14:70842488ENST00000345046-58124_246159247.0Topological domainCytoplasmic
HgeneBCAP31chrX:152969414chr14:70842488ENST00000441714-58124_246159247.0Topological domainCytoplasmic
HgeneBCAP31chrX:152969414chr14:70842488ENST00000458587-58124_246226314.0Topological domainCytoplasmic
TgeneSYNJ2BPchrX:152969414chr14:70842488ENST000002563661413_10067146.0DomainPDZ
TgeneSYNJ2BPchrX:152969414chr14:70842488ENST00000256366141_11767146.0Topological domainCytoplasmic


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Fusion Gene Sequence for BCAP31-SYNJ2BP


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>9157_9157_1_BCAP31-SYNJ2BP_BCAP31_chrX_152969414_ENST00000441714_SYNJ2BP_chr14_70842488_ENST00000256366_length(transcript)=2501nt_BP=704nt
GAGAGTTCTGTTGCTGCGGCGGGGCCTGCACGTTGACTGTGGGAAACTCGGTGAGCGGGCTCCGCGCGCCGGGCTGGGCTCCGGGACCGC
GGAGGCTCCCCGGCCCATCGACGAGGGAGAGAGGCGAGCGGCGCGGGGAGGCCCGGGGGCCGGGGAATCTCGGGGCCCGCAGCCTACCTG
CGTGAAACAAGCTCACATCTTCCTGTGGGAAACCTTCTAGCAACAGGATGAGTCTGCAGTGGACTGCAGTTGCCACCTTCCTCTATGCGG
AGGTCTTTGTTGTGTTGCTTCTCTGCATTCCCTTCATTTCTCCTAAAAGATGGCAGAAGATTTTCAAGTCCCGGCTGGTGGAGTTGTTAG
TGTCCTATGGCAACACCTTCTTTGTGGTTCTCATTGTCATCCTTGTGCTGTTGGTCATCGATGCCGTGCGCGAAATTCGGAAGTATGATG
ATGTGACGGAAAAGGTGAACCTCCAGAACAATCCCGGGGCCATGGAGCACTTCCACATGAAGCTTTTCCGTGCCCAGAGGAATCTCTACA
TTGCTGGCTTTTCCTTGCTGCTGTCCTTCCTGCTTAGACGCCTGGTGACTCTCATTTCGCAGCAGGCCACGCTGCTGGCCTCCAATGAAG
CCTTTAAAAAGCAGGCGGAGAGTGCTAGTGAGGCGGCCAAGAAGTACATGGAGGAGAATGACCAGCTCAAGAAGGTAAATGGCCAAGACC
TAAAGAACCTGCTGCACCAGGATGCTGTAGACCTCTTTCGTAATGCAGGCTATGCTGTGTCTCTGAGAGTGCAGCACAGGTTACAGGTGC
AGAATGGACCTATAGGACATCGAGGTGAAGGGGACCCAAGTGGTATTCCCATATTTATGGTGCTGGTGCCAGTGTTTGCCCTCACCATGG
TAGCAGCCTGGGCTTTCATGAGATACCGGCAACAACTTTGAAAAACTTGCTCTCTTTCAATACTCCCAATGAAGATACATTTCACTCACC
CTCCACCCCTGCTATTCTGCCATGTCTTTCCCTCTCTCTGCATAGCCAGATTTGAAGTGACTGATACCCACCCCAAACCTTGCTGTTCAC
AGTCTCCAATTCTTCATATTCTAATGGGAAAGTAAAGGTATTGTTTGAAGGAAAACTGAAGAAAAGACTTGGCTTAGAACAAATGAGGAG
TTATATATTTTACTAGGACTTTTGATAGAAATTCAGCTACAACCCAAAGAGAGAAAGATTGAGTCTTCCTGTCACCATAGGCAATACCTT
TTTTCTTAGCTGGCATGCCATAAAGGCCAGCTATGTGATATTAGAGGAAGAAAGGATTTTTCTTTTTAATGATCTTCCTTGGGAAATTAT
TGTGGCCTTTATTTAATTTCTAACTACGTACCTGGGTGCCTATATCGACAAAGAGTGAGAAGAGCATTTTTACTTTTTTAAAAAAGCAAA
TACATATATACACATACGTATGCAAATATTATAGTATAATAGTGATCCCTATGGAGAATTAAAGGTGAGAAAGCTACTTTGTGGTGTCTA
GGTTTCTGATAAAAGGGATGATCTTAACTGAAGAATTTAAAGAGATACTTAAACAGAGCAAATGTAGTAGGAACAAGGGAGTGAGCCTTA
TAAGAGGACGTTCAGTCTCATTTATTAAAATAATAACTGAGACTGGGAGAGGTGGCTCATGCCTGTAAATCCCAGCACTTTGGTAGCCTG
AAGTGGGAGATTGCTTGAGTCCAGGAGACCAGCCTGGGCAACATAGCAAAACCTCATCTCTATTTAAAAAAAAAATAGAAAAAAATGTAA
TAACTGAAGCAACTAATTAAAAATCTTAGAAGAACAATATTTATTCTTATAACAGCCAACTATGGTGAGTTATTATAAGGTAAATTGCCA
TAATCCAGCGCTGCTCACATCTAAAAAACTTTGAGGTGTAAAGGTAAATCGTACCAATCTCTGGGCTGCCCTAGTGACTTTTTTGATACC
TCAGAGTCCTATTGAAGAACCAGGTGGAATGATTGTGGTAAGGGCTATAGTGCTGGAGCCAAACACCCCAGCAAGAAAACTCTAAAAGGA
CAAAAGATAAGGTAGTGCCTCCAAGGTGGCACCTGAACCCTCTCAGGCTACTTTTTGGTTTCTACTAACAAACCTGAGGGAAGGAACTGC
CTCCCTGGCAGGATGGGCATCAAATCAACTCTGGCTTCAGATTTAGTTAAAATGAGGCCGGGTGCAGCGGCTCACACCTGTCATCTCAGC
ACTTTGGGAGGCCGAGGCAGGCAGATCACAAGGTCAGGAGTTCAAGACCAGCCTGGCCAACATGGTGAAACCCCATGTCTACTGAAAATA
CAAAAATTACCTGGACATGGTGGCGCGTTCCTGTAATTCCAGCTACTCAGGAGGCTGAGGCAGGAGAACTGTTTGAACCAGGACCTGGGA
GACGGAGGTTGCAGTGAGCCAAGATCACGCCACTGCACTCCAGCCTGGGCTACAGAGCAAGACTCCATCTC

>9157_9157_1_BCAP31-SYNJ2BP_BCAP31_chrX_152969414_ENST00000441714_SYNJ2BP_chr14_70842488_ENST00000256366_length(amino acids)=237AA_BP=159
MSLQWTAVATFLYAEVFVVLLLCIPFISPKRWQKIFKSRLVELLVSYGNTFFVVLIVILVLLVIDAVREIRKYDDVTEKVNLQNNPGAME
HFHMKLFRAQRNLYIAGFSLLLSFLLRRLVTLISQQATLLASNEAFKKQAESASEAAKKYMEENDQLKKVNGQDLKNLLHQDAVDLFRNA
GYAVSLRVQHRLQVQNGPIGHRGEGDPSGIPIFMVLVPVFALTMVAAWAFMRYRQQL

--------------------------------------------------------------
>9157_9157_2_BCAP31-SYNJ2BP_BCAP31_chrX_152969414_ENST00000458587_SYNJ2BP_chr14_70842488_ENST00000256366_length(transcript)=2905nt_BP=1108nt
CTCCGGGACGGTGTGCCAGGCCGGGGCCAAGTCGGAGGCCCCTCGCTCTGGGTGGGCGCTGGGGCCCGCGAGGGCTACTGTAAGGACCCC
TGGCTTCTGAGGATACTGCGTCTAGAACTTTCTCCGTATGGGGCCTTGAGGTGCTTGGTCGAGACCTGCCTTTGCGCTTGGTCCCGAATC
CTGCCCTCTAGGAGTCGCTCTTGCGGGCCTCCAGCCCACCGGAGGCGAAGCGGCCCCGGGCGGAAGGCCGCTGGATCCTCGAGGGAGGTG
CCGGTTTCTCTCCGCGGGCGCCGTGGGGACGGTGGGAGGCGGGGGCGTCGGCAGCGCTTGGACTAGGTGCGGCCTTGGGCCTGCCTGGTA
GCGGGGATTTGGGCCCGCAGAGCGCCCGCCTCTGCGGCTGAGTTCTGCCTGGCGGGGAAGGGAGCGCCCGATGGGTGCCGAGGCGTCCTC
CTCTTGGTGCCCTGGCACTGCTCTTCCCGAAGAACGCCTTTCAGTTAAACGGGCGTCGGAAATCTCGGGCTTCCTGGGGCAGGGATCGTC
GGGAGAGGCCGCTCTGGACGTGTTGACACACGTGCTGGAGGGGGCAGGAAACAAGCTCACATCTTCCTGTGGGAAACCTTCTAGCAACAG
GATGAGTCTGCAGTGGACTGCAGTTGCCACCTTCCTCTATGCGGAGGTCTTTGTTGTGTTGCTTCTCTGCATTCCCTTCATTTCTCCTAA
AAGATGGCAGAAGATTTTCAAGTCCCGGCTGGTGGAGTTGTTAGTGTCCTATGGCAACACCTTCTTTGTGGTTCTCATTGTCATCCTTGT
GCTGTTGGTCATCGATGCCGTGCGCGAAATTCGGAAGTATGATGATGTGACGGAAAAGGTGAACCTCCAGAACAATCCCGGGGCCATGGA
GCACTTCCACATGAAGCTTTTCCGTGCCCAGAGGAATCTCTACATTGCTGGCTTTTCCTTGCTGCTGTCCTTCCTGCTTAGACGCCTGGT
GACTCTCATTTCGCAGCAGGCCACGCTGCTGGCCTCCAATGAAGCCTTTAAAAAGCAGGCGGAGAGTGCTAGTGAGGCGGCCAAGAAGTA
CATGGAGGAGAATGACCAGCTCAAGAAGGTAAATGGCCAAGACCTAAAGAACCTGCTGCACCAGGATGCTGTAGACCTCTTTCGTAATGC
AGGCTATGCTGTGTCTCTGAGAGTGCAGCACAGGTTACAGGTGCAGAATGGACCTATAGGACATCGAGGTGAAGGGGACCCAAGTGGTAT
TCCCATATTTATGGTGCTGGTGCCAGTGTTTGCCCTCACCATGGTAGCAGCCTGGGCTTTCATGAGATACCGGCAACAACTTTGAAAAAC
TTGCTCTCTTTCAATACTCCCAATGAAGATACATTTCACTCACCCTCCACCCCTGCTATTCTGCCATGTCTTTCCCTCTCTCTGCATAGC
CAGATTTGAAGTGACTGATACCCACCCCAAACCTTGCTGTTCACAGTCTCCAATTCTTCATATTCTAATGGGAAAGTAAAGGTATTGTTT
GAAGGAAAACTGAAGAAAAGACTTGGCTTAGAACAAATGAGGAGTTATATATTTTACTAGGACTTTTGATAGAAATTCAGCTACAACCCA
AAGAGAGAAAGATTGAGTCTTCCTGTCACCATAGGCAATACCTTTTTTCTTAGCTGGCATGCCATAAAGGCCAGCTATGTGATATTAGAG
GAAGAAAGGATTTTTCTTTTTAATGATCTTCCTTGGGAAATTATTGTGGCCTTTATTTAATTTCTAACTACGTACCTGGGTGCCTATATC
GACAAAGAGTGAGAAGAGCATTTTTACTTTTTTAAAAAAGCAAATACATATATACACATACGTATGCAAATATTATAGTATAATAGTGAT
CCCTATGGAGAATTAAAGGTGAGAAAGCTACTTTGTGGTGTCTAGGTTTCTGATAAAAGGGATGATCTTAACTGAAGAATTTAAAGAGAT
ACTTAAACAGAGCAAATGTAGTAGGAACAAGGGAGTGAGCCTTATAAGAGGACGTTCAGTCTCATTTATTAAAATAATAACTGAGACTGG
GAGAGGTGGCTCATGCCTGTAAATCCCAGCACTTTGGTAGCCTGAAGTGGGAGATTGCTTGAGTCCAGGAGACCAGCCTGGGCAACATAG
CAAAACCTCATCTCTATTTAAAAAAAAAATAGAAAAAAATGTAATAACTGAAGCAACTAATTAAAAATCTTAGAAGAACAATATTTATTC
TTATAACAGCCAACTATGGTGAGTTATTATAAGGTAAATTGCCATAATCCAGCGCTGCTCACATCTAAAAAACTTTGAGGTGTAAAGGTA
AATCGTACCAATCTCTGGGCTGCCCTAGTGACTTTTTTGATACCTCAGAGTCCTATTGAAGAACCAGGTGGAATGATTGTGGTAAGGGCT
ATAGTGCTGGAGCCAAACACCCCAGCAAGAAAACTCTAAAAGGACAAAAGATAAGGTAGTGCCTCCAAGGTGGCACCTGAACCCTCTCAG
GCTACTTTTTGGTTTCTACTAACAAACCTGAGGGAAGGAACTGCCTCCCTGGCAGGATGGGCATCAAATCAACTCTGGCTTCAGATTTAG
TTAAAATGAGGCCGGGTGCAGCGGCTCACACCTGTCATCTCAGCACTTTGGGAGGCCGAGGCAGGCAGATCACAAGGTCAGGAGTTCAAG
ACCAGCCTGGCCAACATGGTGAAACCCCATGTCTACTGAAAATACAAAAATTACCTGGACATGGTGGCGCGTTCCTGTAATTCCAGCTAC
TCAGGAGGCTGAGGCAGGAGAACTGTTTGAACCAGGACCTGGGAGACGGAGGTTGCAGTGAGCCAAGATCACGCCACTGCACTCCAGCCT
GGGCTACAGAGCAAGACTCCATCTC

>9157_9157_2_BCAP31-SYNJ2BP_BCAP31_chrX_152969414_ENST00000458587_SYNJ2BP_chr14_70842488_ENST00000256366_length(amino acids)=317AA_BP=239
MRLSSAWRGRERPMGAEASSSWCPGTALPEERLSVKRASEISGFLGQGSSGEAALDVLTHVLEGAGNKLTSSCGKPSSNRMSLQWTAVAT
FLYAEVFVVLLLCIPFISPKRWQKIFKSRLVELLVSYGNTFFVVLIVILVLLVIDAVREIRKYDDVTEKVNLQNNPGAMEHFHMKLFRAQ
RNLYIAGFSLLLSFLLRRLVTLISQQATLLASNEAFKKQAESASEAAKKYMEENDQLKKVNGQDLKNLLHQDAVDLFRNAGYAVSLRVQH
RLQVQNGPIGHRGEGDPSGIPIFMVLVPVFALTMVAAWAFMRYRQQL

--------------------------------------------------------------

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Fusion Gene PPI Analysis for BCAP31-SYNJ2BP


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for BCAP31-SYNJ2BP


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for BCAP31-SYNJ2BP


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneBCAP31C1845408Contiguous Abcd1-Dxs1375e Deletion Syndrome2CTD_human;ORPHANET
HgeneBCAP31C3806634DEAFNESS, DYSTONIA, AND CEREBRAL HYPOMYELINATION1GENOMICS_ENGLAND;ORPHANET