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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ARFRP1-ADRM1 (FusionGDB2 ID:HG10139TG11047)

Fusion Gene Summary for ARFRP1-ADRM1

check button Fusion gene summary
Fusion gene informationFusion gene name: ARFRP1-ADRM1
Fusion gene ID: hg10139tg11047
HgeneTgene
Gene symbol

ARFRP1

ADRM1

Gene ID

10139

11047

Gene nameADP ribosylation factor related protein 1adhesion regulating molecule 1
SynonymsARL18|ARP|Arp1ARM-1|ARM1|GP110
Cytomap('ARFRP1')('ADRM1')

20q13.33

20q13.33

Type of geneprotein-codingprotein-coding
DescriptionADP-ribosylation factor-related protein 1ARF-related protein 1SCG10 like-proteinepididymis secretory sperm binding proteinhelicase-like protein NHLproteasomal ubiquitin receptor ADRM1110 kDa cell membrane glycoproteinM(r) 110,000 surface antigenproteasome regulatory particle non-ATPase 13proteasome ubiquitin receptorrpn13 homolog
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000324228, ENST00000359715, 
ENST00000440854, ENST00000607873, 
ENST00000609142, ENST00000485858, 
Fusion gene scores* DoF score4 X 4 X 2=328 X 6 X 5=240
# samples 48
** MAII scorelog2(4/32*10)=0.321928094887362
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(8/240*10)=-1.58496250072116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ARFRP1 [Title/Abstract] AND ADRM1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointARFRP1(62337708)-ADRM1(60881252), # samples:1
Anticipated loss of major functional domain due to fusion event.ARFRP1-ADRM1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ARFRP1-ADRM1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ARFRP1-ADRM1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ARFRP1-ADRM1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ARFRP1-ADRM1 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneADRM1

GO:0043248

proteasome assembly

16990800


check buttonFusion gene breakpoints across ARFRP1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across ADRM1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4COADTCGA-A6-5656ARFRP1chr20

62337708

-ADRM1chr20

60881252

+


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Fusion Gene ORF analysis for ARFRP1-ADRM1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000324228ENST00000462554ARFRP1chr20

62337708

-ADRM1chr20

60881252

+
5CDS-3UTRENST00000359715ENST00000462554ARFRP1chr20

62337708

-ADRM1chr20

60881252

+
5CDS-3UTRENST00000440854ENST00000462554ARFRP1chr20

62337708

-ADRM1chr20

60881252

+
5CDS-3UTRENST00000607873ENST00000462554ARFRP1chr20

62337708

-ADRM1chr20

60881252

+
5CDS-3UTRENST00000609142ENST00000462554ARFRP1chr20

62337708

-ADRM1chr20

60881252

+
Frame-shiftENST00000609142ENST00000253003ARFRP1chr20

62337708

-ADRM1chr20

60881252

+
In-frameENST00000324228ENST00000253003ARFRP1chr20

62337708

-ADRM1chr20

60881252

+
In-frameENST00000359715ENST00000253003ARFRP1chr20

62337708

-ADRM1chr20

60881252

+
In-frameENST00000440854ENST00000253003ARFRP1chr20

62337708

-ADRM1chr20

60881252

+
In-frameENST00000607873ENST00000253003ARFRP1chr20

62337708

-ADRM1chr20

60881252

+
intron-3CDSENST00000485858ENST00000253003ARFRP1chr20

62337708

-ADRM1chr20

60881252

+
intron-3UTRENST00000485858ENST00000462554ARFRP1chr20

62337708

-ADRM1chr20

60881252

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000440854ARFRP1chr2062337708-ENST00000253003ADRM1chr2060881252+13974021381295385
ENST00000359715ARFRP1chr2062337708-ENST00000253003ADRM1chr2060881252+18268315311724397
ENST00000324228ARFRP1chr2062337708-ENST00000253003ADRM1chr2060881252+1289294301187385
ENST00000607873ARFRP1chr2062337708-ENST00000253003ADRM1chr2060881252+13253301651223352

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000440854ENST00000253003ARFRP1chr2062337708-ADRM1chr2060881252+0.0110524580.9889475
ENST00000359715ENST00000253003ARFRP1chr2062337708-ADRM1chr2060881252+0.0179472830.98205274
ENST00000324228ENST00000253003ARFRP1chr2062337708-ADRM1chr2060881252+0.0108764890.9891235
ENST00000607873ENST00000253003ARFRP1chr2062337708-ADRM1chr2060881252+0.0080944390.99190557

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Fusion Genomic Features for ARFRP1-ADRM1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
ARFRP1chr2062337708-ADRM1chr2060881252+1.89E-060.9999981
ARFRP1chr2062337708-ADRM1chr2060881252+1.89E-060.9999981

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for ARFRP1-ADRM1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr20:62337708/chr20:60881252)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneARFRP1chr20:62337708chr20:60881252ENST00000324228-4824_3188202.0Nucleotide bindingGTP
HgeneARFRP1chr20:62337708chr20:60881252ENST00000324228-4875_7988202.0Nucleotide bindingGTP
HgeneARFRP1chr20:62337708chr20:60881252ENST00000359715-3724_3188202.0Nucleotide bindingGTP
HgeneARFRP1chr20:62337708chr20:60881252ENST00000359715-3775_7988202.0Nucleotide bindingGTP
HgeneARFRP1chr20:62337708chr20:60881252ENST00000440854-4724_3188174.0Nucleotide bindingGTP
HgeneARFRP1chr20:62337708chr20:60881252ENST00000440854-4775_7988174.0Nucleotide bindingGTP
TgeneADRM1chr20:62337708chr20:60881252ENST00000253003210135_202110408.0Compositional biasNote=Gly-rich
TgeneADRM1chr20:62337708chr20:60881252ENST00000253003210193_257110408.0Compositional biasNote=Ser-rich
TgeneADRM1chr20:62337708chr20:60881252ENST00000253003210203_213110408.0Compositional biasNote=Poly-Ser
TgeneADRM1chr20:62337708chr20:60881252ENST00000253003210277_391110408.0DomainDEUBAD

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneARFRP1chr20:62337708chr20:60881252ENST00000324228-48134_13788202.0Nucleotide bindingGTP
HgeneARFRP1chr20:62337708chr20:60881252ENST00000359715-37134_13788202.0Nucleotide bindingGTP
HgeneARFRP1chr20:62337708chr20:60881252ENST00000440854-47134_13788174.0Nucleotide bindingGTP
TgeneADRM1chr20:62337708chr20:60881252ENST0000025300321018_131110408.0DomainPru


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Fusion Gene Sequence for ARFRP1-ADRM1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>5902_5902_1_ARFRP1-ADRM1_ARFRP1_chr20_62337708_ENST00000324228_ADRM1_chr20_60881252_ENST00000253003_length(transcript)=1289nt_BP=294nt
GAGGCCCGAGGGGCGGCCCAGGACTCGAGGATGTACACGCTGCTGTCGGGCTTGTACAAGTACATGTTTCAGAAGGACGAGTACTGCATC
CTGATCCTGGGCCTGGACAATGCTGGGAAGACGACCTTCCTGGAGCAGTCGAAAACCCGATTTAACAAGAACTACAAGGGGATGAGTCTA
TCCAAAATCACCACCACCGTGGGCCTAAACATCGGCACTGTGGATGTGGGAAAGGCTCGGCTCATGTTCTGGGACTTAGGAGGGCAGGAA
GAGCTGCAGTCTTTGTGGGACAAGGAACCCAAGACAGACCAGGATGAGGAGCATTGCCGGAAAGTCAACGAGTATCTGAACAACCCCCCG
ATGCCTGGGGCGCTGGGGGCCAGCGGAAGCAGCGGCCACGAACTCTCTGCGCTAGGCGGTGAGGGTGGCCTGCAGAGCCTGCTGGGAAAC
ATGAGCCACAGCCAGCTCATGCAGCTCATCGGACCAGCCGGCCTTGGAGGACTGGGTGGGCTGGGGGCCCTGACTGGACCTGGCCTGGCC
AGCTTACTGGGGAGCAGTGGGCCTCCAGGGAGCAGCTCCTCCTCCAGCTCCCGGAGCCAGTCGGCAGCGGTCACCCCGTCATCCACCACC
TCTTCCACCCGTGCCACCCCAGCCCCTTCTGCTCCAGCAGCTGCCTCAGCAACTAGCCCGAGCCCCGCGCCCAGTTCCGGGAATGGAGCC
AGCACAGCAGCCAGCCCGACCCAGCCCATCCAGCTGAGCGACCTCCAGAGCATCCTGGCCACGATGAACGTACCAGCCGGGCCAGCAGGC
GGCCAGCAAGTGGACCTGGCCAGTGTGCTGACGCCGGAGATAATGGCTCCCATCCTCGCCAACGCGGATGTCCAGGAGCGCCTGCTTCCC
TACTTGCCATCTGGGGAGTCGCTGCCGCAGACCGCGGATGAGATCCAGAATACCCTGACCTCGCCCCAGTTCCAGCAGGCCCTGGGCATG
TTCAGCGCAGCCTTGGCCTCGGGGCAGCTGGGCCCCCTCATGTGCCAGTTCGGTCTGCCTGCAGAGGCTGTGGAGGCCGCCAACAAGGGC
GATGTGGAAGCGTTTGCCAAAGCCATGCAGAACAACGCCAAGCCCGAGCAGAAAGAGGGCGACACGAAGGACAAGAAGGACGAAGAGGAG
GACATGAGCCTGGACTGAGCCACGCGCCGTCCTCCGAGGAACTGGGCGCTTGCAGTGCGTTGCACACCCTCACCTCCCACCCACTGATTA

>5902_5902_1_ARFRP1-ADRM1_ARFRP1_chr20_62337708_ENST00000324228_ADRM1_chr20_60881252_ENST00000253003_length(amino acids)=385AA_BP=0
MYTLLSGLYKYMFQKDEYCILILGLDNAGKTTFLEQSKTRFNKNYKGMSLSKITTTVGLNIGTVDVGKARLMFWDLGGQEELQSLWDKEP
KTDQDEEHCRKVNEYLNNPPMPGALGASGSSGHELSALGGEGGLQSLLGNMSHSQLMQLIGPAGLGGLGGLGALTGPGLASLLGSSGPPG
SSSSSSSRSQSAAVTPSSTTSSTRATPAPSAPAAASATSPSPAPSSGNGASTAASPTQPIQLSDLQSILATMNVPAGPAGGQQVDLASVL
TPEIMAPILANADVQERLLPYLPSGESLPQTADEIQNTLTSPQFQQALGMFSAALASGQLGPLMCQFGLPAEAVEAANKGDVEAFAKAMQ

--------------------------------------------------------------
>5902_5902_2_ARFRP1-ADRM1_ARFRP1_chr20_62337708_ENST00000359715_ADRM1_chr20_60881252_ENST00000253003_length(transcript)=1826nt_BP=831nt
GCACTCCAGGAGCAGCCGCGCCGCTGCTCACCCGCCCTGTAGTCCGCTCCCCCCAGGGCCGTCCCCGTTTTAAGAAATGGGGTGATGGGG
CGTCCCTACCCGGCGCCTGCAGGGGCTCCTGGGGAGCGCGCCGGTGGCTCGCTGCTCCCGGGTGGGGCGCGGGGCTGGCGCTCGAGGGTG
CCGTGGCCCAGGCGGGGCTGCAGCGAGTGTGTTCCCCGTTCCGCGCGCGTGAAGCGTGGGAGCGAAGCCTCGGGGGAGGGCGGGAGCGCG
GCTGAGCTCACTGTGAACACCCGGCTGGGTAGTCCCGCGAGCAGGGGAGGGGCCGGAACCGATGTGTATGCGGAGAGGTCGCAGTCATTG
CTGTGAGCAGGACACAGTGGCGGCTGACCTGGGAGAAGTTACAGAGGGACGGGGTGGGAGAGGGACGAGGAGTCGGGAATGGCCCCCAGG
CTCTCGTCCTGAGCGGTCGGCTGGACGTGGGGCGCCACTGACCACCGTGGAGAAGCCCGGGGGAGGGGAGGTGCTTTCTGGCTGCACACT
GACCTATGTTGGGGTGCCCAGGGCAGGATGTACACGCTGCTGTCGGGCTTGTACAAGTACATGTTTCAGAAGGACGAGTACTGCATCCTG
ATCCTGGGCCTGGACAATGCTGGGAAGACGACCTTCCTGGAGCAGTCGAAAACCCGATTTAACAAGAACTACAAGGGGATGAGTCTATCC
AAAATCACCACCACCGTGGGCCTAAACATCGGCACTGTGGATGTGGGAAAGGCTCGGCTCATGTTCTGGGACTTAGGAGGGCAGGAAGAG
CTGCAGTCTTTGTGGGACAAGGAACCCAAGACAGACCAGGATGAGGAGCATTGCCGGAAAGTCAACGAGTATCTGAACAACCCCCCGATG
CCTGGGGCGCTGGGGGCCAGCGGAAGCAGCGGCCACGAACTCTCTGCGCTAGGCGGTGAGGGTGGCCTGCAGAGCCTGCTGGGAAACATG
AGCCACAGCCAGCTCATGCAGCTCATCGGACCAGCCGGCCTTGGAGGACTGGGTGGGCTGGGGGCCCTGACTGGACCTGGCCTGGCCAGC
TTACTGGGGAGCAGTGGGCCTCCAGGGAGCAGCTCCTCCTCCAGCTCCCGGAGCCAGTCGGCAGCGGTCACCCCGTCATCCACCACCTCT
TCCACCCGTGCCACCCCAGCCCCTTCTGCTCCAGCAGCTGCCTCAGCAACTAGCCCGAGCCCCGCGCCCAGTTCCGGGAATGGAGCCAGC
ACAGCAGCCAGCCCGACCCAGCCCATCCAGCTGAGCGACCTCCAGAGCATCCTGGCCACGATGAACGTACCAGCCGGGCCAGCAGGCGGC
CAGCAAGTGGACCTGGCCAGTGTGCTGACGCCGGAGATAATGGCTCCCATCCTCGCCAACGCGGATGTCCAGGAGCGCCTGCTTCCCTAC
TTGCCATCTGGGGAGTCGCTGCCGCAGACCGCGGATGAGATCCAGAATACCCTGACCTCGCCCCAGTTCCAGCAGGCCCTGGGCATGTTC
AGCGCAGCCTTGGCCTCGGGGCAGCTGGGCCCCCTCATGTGCCAGTTCGGTCTGCCTGCAGAGGCTGTGGAGGCCGCCAACAAGGGCGAT
GTGGAAGCGTTTGCCAAAGCCATGCAGAACAACGCCAAGCCCGAGCAGAAAGAGGGCGACACGAAGGACAAGAAGGACGAAGAGGAGGAC
ATGAGCCTGGACTGAGCCACGCGCCGTCCTCCGAGGAACTGGGCGCTTGCAGTGCGTTGCACACCCTCACCTCCCACCCACTGATTATTA

>5902_5902_2_ARFRP1-ADRM1_ARFRP1_chr20_62337708_ENST00000359715_ADRM1_chr20_60881252_ENST00000253003_length(amino acids)=397AA_BP=1
MHTDLCWGAQGRMYTLLSGLYKYMFQKDEYCILILGLDNAGKTTFLEQSKTRFNKNYKGMSLSKITTTVGLNIGTVDVGKARLMFWDLGG
QEELQSLWDKEPKTDQDEEHCRKVNEYLNNPPMPGALGASGSSGHELSALGGEGGLQSLLGNMSHSQLMQLIGPAGLGGLGGLGALTGPG
LASLLGSSGPPGSSSSSSSRSQSAAVTPSSTTSSTRATPAPSAPAAASATSPSPAPSSGNGASTAASPTQPIQLSDLQSILATMNVPAGP
AGGQQVDLASVLTPEIMAPILANADVQERLLPYLPSGESLPQTADEIQNTLTSPQFQQALGMFSAALASGQLGPLMCQFGLPAEAVEAAN

--------------------------------------------------------------
>5902_5902_3_ARFRP1-ADRM1_ARFRP1_chr20_62337708_ENST00000440854_ADRM1_chr20_60881252_ENST00000253003_length(transcript)=1397nt_BP=402nt
GGAGGCCGCTGGGACGCGGTTCAGCTCATTCCCTGAGGCCGGCCCGCGTCCCGTCAGGCGCCGCGCGGGGTTAGCGCGGGGTCAGCGGAG
GTCAGCGGGGGTCAGCAGCAGCGGCTCCGAGGGCGCGGCGGACGCAGGATGTACACGCTGCTGTCGGGCTTGTACAAGTACATGTTTCAG
AAGGACGAGTACTGCATCCTGATCCTGGGCCTGGACAATGCTGGGAAGACGACCTTCCTGGAGCAGTCGAAAACCCGATTTAACAAGAAC
TACAAGGGGATGAGTCTATCCAAAATCACCACCACCGTGGGCCTAAACATCGGCACTGTGGATGTGGGAAAGGCTCGGCTCATGTTCTGG
GACTTAGGAGGGCAGGAAGAGCTGCAGTCTTTGTGGGACAAGGAACCCAAGACAGACCAGGATGAGGAGCATTGCCGGAAAGTCAACGAG
TATCTGAACAACCCCCCGATGCCTGGGGCGCTGGGGGCCAGCGGAAGCAGCGGCCACGAACTCTCTGCGCTAGGCGGTGAGGGTGGCCTG
CAGAGCCTGCTGGGAAACATGAGCCACAGCCAGCTCATGCAGCTCATCGGACCAGCCGGCCTTGGAGGACTGGGTGGGCTGGGGGCCCTG
ACTGGACCTGGCCTGGCCAGCTTACTGGGGAGCAGTGGGCCTCCAGGGAGCAGCTCCTCCTCCAGCTCCCGGAGCCAGTCGGCAGCGGTC
ACCCCGTCATCCACCACCTCTTCCACCCGTGCCACCCCAGCCCCTTCTGCTCCAGCAGCTGCCTCAGCAACTAGCCCGAGCCCCGCGCCC
AGTTCCGGGAATGGAGCCAGCACAGCAGCCAGCCCGACCCAGCCCATCCAGCTGAGCGACCTCCAGAGCATCCTGGCCACGATGAACGTA
CCAGCCGGGCCAGCAGGCGGCCAGCAAGTGGACCTGGCCAGTGTGCTGACGCCGGAGATAATGGCTCCCATCCTCGCCAACGCGGATGTC
CAGGAGCGCCTGCTTCCCTACTTGCCATCTGGGGAGTCGCTGCCGCAGACCGCGGATGAGATCCAGAATACCCTGACCTCGCCCCAGTTC
CAGCAGGCCCTGGGCATGTTCAGCGCAGCCTTGGCCTCGGGGCAGCTGGGCCCCCTCATGTGCCAGTTCGGTCTGCCTGCAGAGGCTGTG
GAGGCCGCCAACAAGGGCGATGTGGAAGCGTTTGCCAAAGCCATGCAGAACAACGCCAAGCCCGAGCAGAAAGAGGGCGACACGAAGGAC
AAGAAGGACGAAGAGGAGGACATGAGCCTGGACTGAGCCACGCGCCGTCCTCCGAGGAACTGGGCGCTTGCAGTGCGTTGCACACCCTCA

>5902_5902_3_ARFRP1-ADRM1_ARFRP1_chr20_62337708_ENST00000440854_ADRM1_chr20_60881252_ENST00000253003_length(amino acids)=385AA_BP=0
MYTLLSGLYKYMFQKDEYCILILGLDNAGKTTFLEQSKTRFNKNYKGMSLSKITTTVGLNIGTVDVGKARLMFWDLGGQEELQSLWDKEP
KTDQDEEHCRKVNEYLNNPPMPGALGASGSSGHELSALGGEGGLQSLLGNMSHSQLMQLIGPAGLGGLGGLGALTGPGLASLLGSSGPPG
SSSSSSSRSQSAAVTPSSTTSSTRATPAPSAPAAASATSPSPAPSSGNGASTAASPTQPIQLSDLQSILATMNVPAGPAGGQQVDLASVL
TPEIMAPILANADVQERLLPYLPSGESLPQTADEIQNTLTSPQFQQALGMFSAALASGQLGPLMCQFGLPAEAVEAANKGDVEAFAKAMQ

--------------------------------------------------------------
>5902_5902_4_ARFRP1-ADRM1_ARFRP1_chr20_62337708_ENST00000607873_ADRM1_chr20_60881252_ENST00000253003_length(transcript)=1325nt_BP=330nt
GGGCAGCCGGGAAGCGGAGCGCGGAGGCCGCTGGGACGCGGTTCAGCTCATTCCCTGAGGCCGGCCCGCGTCCCGTCAGGCGCCGCGCGG
GGTTAGCGCGGGGTCAGCGGAGGTCAGCGGGGGTCAGCAGCAGCGGCTCCGAGGGCGCGGCGGACGCAGACCTTCCTGGAGCAGTCGAAA
ACCCGATTTAACAAGAACTACAAGGGGATGAGTCTATCCAAAATCACCACCACCGTGGGCCTAAACATCGGCACTGTGGATGTGGGAAAG
GCTCGGCTCATGTTCTGGGACTTAGGAGGGCAGGAAGAGCTGCAGTCTTTGTGGGACAAGGAACCCAAGACAGACCAGGATGAGGAGCAT
TGCCGGAAAGTCAACGAGTATCTGAACAACCCCCCGATGCCTGGGGCGCTGGGGGCCAGCGGAAGCAGCGGCCACGAACTCTCTGCGCTA
GGCGGTGAGGGTGGCCTGCAGAGCCTGCTGGGAAACATGAGCCACAGCCAGCTCATGCAGCTCATCGGACCAGCCGGCCTTGGAGGACTG
GGTGGGCTGGGGGCCCTGACTGGACCTGGCCTGGCCAGCTTACTGGGGAGCAGTGGGCCTCCAGGGAGCAGCTCCTCCTCCAGCTCCCGG
AGCCAGTCGGCAGCGGTCACCCCGTCATCCACCACCTCTTCCACCCGTGCCACCCCAGCCCCTTCTGCTCCAGCAGCTGCCTCAGCAACT
AGCCCGAGCCCCGCGCCCAGTTCCGGGAATGGAGCCAGCACAGCAGCCAGCCCGACCCAGCCCATCCAGCTGAGCGACCTCCAGAGCATC
CTGGCCACGATGAACGTACCAGCCGGGCCAGCAGGCGGCCAGCAAGTGGACCTGGCCAGTGTGCTGACGCCGGAGATAATGGCTCCCATC
CTCGCCAACGCGGATGTCCAGGAGCGCCTGCTTCCCTACTTGCCATCTGGGGAGTCGCTGCCGCAGACCGCGGATGAGATCCAGAATACC
CTGACCTCGCCCCAGTTCCAGCAGGCCCTGGGCATGTTCAGCGCAGCCTTGGCCTCGGGGCAGCTGGGCCCCCTCATGTGCCAGTTCGGT
CTGCCTGCAGAGGCTGTGGAGGCCGCCAACAAGGGCGATGTGGAAGCGTTTGCCAAAGCCATGCAGAACAACGCCAAGCCCGAGCAGAAA
GAGGGCGACACGAAGGACAAGAAGGACGAAGAGGAGGACATGAGCCTGGACTGAGCCACGCGCCGTCCTCCGAGGAACTGGGCGCTTGCA

>5902_5902_4_ARFRP1-ADRM1_ARFRP1_chr20_62337708_ENST00000607873_ADRM1_chr20_60881252_ENST00000253003_length(amino acids)=352AA_BP=1
MEQSKTRFNKNYKGMSLSKITTTVGLNIGTVDVGKARLMFWDLGGQEELQSLWDKEPKTDQDEEHCRKVNEYLNNPPMPGALGASGSSGH
ELSALGGEGGLQSLLGNMSHSQLMQLIGPAGLGGLGGLGALTGPGLASLLGSSGPPGSSSSSSSRSQSAAVTPSSTTSSTRATPAPSAPA
AASATSPSPAPSSGNGASTAASPTQPIQLSDLQSILATMNVPAGPAGGQQVDLASVLTPEIMAPILANADVQERLLPYLPSGESLPQTAD

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Fusion Gene PPI Analysis for ARFRP1-ADRM1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
TgeneADRM1chr20:62337708chr20:60881252ENST00000253003210253_407110.0408.0UCHL5


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ARFRP1-ADRM1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ARFRP1-ADRM1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource