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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:AKAP9-AKAP9 (FusionGDB2 ID:HG10142TG10142)

Fusion Gene Summary for AKAP9-AKAP9

check button Fusion gene summary
Fusion gene informationFusion gene name: AKAP9-AKAP9
Fusion gene ID: hg10142tg10142
HgeneTgene
Gene symbol

AKAP9

AKAP9

Gene ID

10142

10142

Gene nameA-kinase anchoring protein 9A-kinase anchoring protein 9
SynonymsAKAP-9|AKAP350|AKAP450|CG-NAP|HYPERION|LQT11|MU-RMS-40.16A|PPP1R45|PRKA9|YOTIAOAKAP-9|AKAP350|AKAP450|CG-NAP|HYPERION|LQT11|MU-RMS-40.16A|PPP1R45|PRKA9|YOTIAO
Cytomap('AKAP9')('AKAP9')

7q21.2

7q21.2

Type of geneprotein-codingprotein-coding
DescriptionA-kinase anchor protein 9A kinase (PRKA) anchor protein (yotiao) 9A kinase (PRKA) anchor protein 9A-kinase anchor protein 350 kDaA-kinase anchor protein 450 kDaAKAP 120-like proteinAKAP9-BRAF fusion proteincentrosome- and Golgi-localized PKN-associA-kinase anchor protein 9A kinase (PRKA) anchor protein (yotiao) 9A kinase (PRKA) anchor protein 9A-kinase anchor protein 350 kDaA-kinase anchor protein 450 kDaAKAP 120-like proteinAKAP9-BRAF fusion proteincentrosome- and Golgi-localized PKN-associ
Modification date2020032820200328
UniProtAcc

Q99996

Q99996

Ensembl transtripts involved in fusion geneENST00000356239, ENST00000358100, 
ENST00000359028, ENST00000394564, 
ENST00000491695, 
ENST00000491695, 
ENST00000356239, ENST00000358100, 
ENST00000359028, ENST00000394564, 
Fusion gene scores* DoF score17 X 21 X 11=392711 X 17 X 7=1309
# samples 2815
** MAII scorelog2(28/3927*10)=-3.80992886572143
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(15/1309*10)=-3.12543069144936
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: AKAP9 [Title/Abstract] AND AKAP9 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointAKAP9(91630522)-AKAP9(91622250), # samples:2
Anticipated loss of major functional domain due to fusion event.AKAP9-AKAP9 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
AKAP9-AKAP9 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
AKAP9-AKAP9 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
AKAP9-AKAP9 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneAKAP9

GO:0098962

regulation of postsynaptic neurotransmitter receptor activity

10390370

HgeneAKAP9

GO:1903358

regulation of Golgi organization

27666745

TgeneAKAP9

GO:0098962

regulation of postsynaptic neurotransmitter receptor activity

10390370

TgeneAKAP9

GO:1903358

regulation of Golgi organization

27666745


check buttonFusion gene breakpoints across AKAP9 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across AKAP9 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand


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Fusion Gene ORF analysis for AKAP9-AKAP9

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for AKAP9-AKAP9


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

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Fusion Protein Features for AKAP9-AKAP9


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr7:91630522/chr7:91622250)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
AKAP9

Q99996

AKAP9

Q99996

FUNCTION: Scaffolding protein that assembles several protein kinases and phosphatases on the centrosome and Golgi apparatus. Required to maintain the integrity of the Golgi apparatus (PubMed:10202149, PubMed:15047863). Required for microtubule nucleation at the cis-side of the Golgi apparatus (PubMed:15047863, PubMed:19242490). Required for association of the centrosomes with the poles of the bipolar mitotic spindle during metaphase (PubMed:25657325). In complex with PDE4DIP isoform 13/MMG8/SMYLE, recruits CAMSAP2 to the Golgi apparatus and tethers non-centrosomal minus-end microtubules to the Golgi, an important step for polarized cell movement (PubMed:27666745, PubMed:28814570). In complex with PDE4DIP isoform 13/MMG8/SMYLE, EB1/MAPRE1 and CDK5RAP2, contributes to microtubules nucleation and extension also from the centrosome to the cell periphery (PubMed:29162697). {ECO:0000269|PubMed:10202149, ECO:0000269|PubMed:15047863, ECO:0000269|PubMed:19242490, ECO:0000269|PubMed:25657325, ECO:0000269|PubMed:27666745, ECO:0000269|PubMed:28814570, ECO:0000269|PubMed:29162697}.; FUNCTION: [Isoform 4]: Associated with the N-methyl-D-aspartate receptor and is specifically found in the neuromuscular junction (NMJ) as well as in neuronal synapses, suggesting a role in the organization of postsynaptic specializations. {ECO:0000269|PubMed:9482789}.FUNCTION: Scaffolding protein that assembles several protein kinases and phosphatases on the centrosome and Golgi apparatus. Required to maintain the integrity of the Golgi apparatus (PubMed:10202149, PubMed:15047863). Required for microtubule nucleation at the cis-side of the Golgi apparatus (PubMed:15047863, PubMed:19242490). Required for association of the centrosomes with the poles of the bipolar mitotic spindle during metaphase (PubMed:25657325). In complex with PDE4DIP isoform 13/MMG8/SMYLE, recruits CAMSAP2 to the Golgi apparatus and tethers non-centrosomal minus-end microtubules to the Golgi, an important step for polarized cell movement (PubMed:27666745, PubMed:28814570). In complex with PDE4DIP isoform 13/MMG8/SMYLE, EB1/MAPRE1 and CDK5RAP2, contributes to microtubules nucleation and extension also from the centrosome to the cell periphery (PubMed:29162697). {ECO:0000269|PubMed:10202149, ECO:0000269|PubMed:15047863, ECO:0000269|PubMed:19242490, ECO:0000269|PubMed:25657325, ECO:0000269|PubMed:27666745, ECO:0000269|PubMed:28814570, ECO:0000269|PubMed:29162697}.; FUNCTION: [Isoform 4]: Associated with the N-methyl-D-aspartate receptor and is specifically found in the neuromuscular junction (NMJ) as well as in neuronal synapses, suggesting a role in the organization of postsynaptic specializations. {ECO:0000269|PubMed:9482789}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneAKAP9chr7:91630522chr7:91622250ENST000003562390501088_117303908.0Coiled coilOntology_term=ECO:0000255
TgeneAKAP9chr7:91630522chr7:91622250ENST000003562390501241_126803908.0Coiled coilOntology_term=ECO:0000255
TgeneAKAP9chr7:91630522chr7:91622250ENST000003562390501324_138003908.0Coiled coilOntology_term=ECO:0000255
TgeneAKAP9chr7:91630522chr7:91622250ENST000003562390501422_144703908.0Coiled coilOntology_term=ECO:0000255
TgeneAKAP9chr7:91630522chr7:91622250ENST00000356239050152_90203908.0Coiled coilOntology_term=ECO:0000255
TgeneAKAP9chr7:91630522chr7:91622250ENST000003562390501573_164703908.0Coiled coilOntology_term=ECO:0000255
TgeneAKAP9chr7:91630522chr7:91622250ENST000003562390501845_244303908.0Coiled coilOntology_term=ECO:0000255
TgeneAKAP9chr7:91630522chr7:91622250ENST000003562390502532_254903908.0Coiled coilOntology_term=ECO:0000255
TgeneAKAP9chr7:91630522chr7:91622250ENST000003562390502591_276403908.0Coiled coilOntology_term=ECO:0000255
TgeneAKAP9chr7:91630522chr7:91622250ENST000003562390503061_308803908.0Coiled coilOntology_term=ECO:0000255
TgeneAKAP9chr7:91630522chr7:91622250ENST000003562390503120_346603908.0Coiled coilOntology_term=ECO:0000255
TgeneAKAP9chr7:91630522chr7:91622250ENST000003562390503583_368503908.0Coiled coilOntology_term=ECO:0000255
TgeneAKAP9chr7:91630522chr7:91622250ENST00000356239050932_101003908.0Coiled coilOntology_term=ECO:0000255
TgeneAKAP9chr7:91630522chr7:91622250ENST000003581000491088_117303858.0Coiled coilOntology_term=ECO:0000255
TgeneAKAP9chr7:91630522chr7:91622250ENST000003581000491241_126803858.0Coiled coilOntology_term=ECO:0000255
TgeneAKAP9chr7:91630522chr7:91622250ENST000003581000491324_138003858.0Coiled coilOntology_term=ECO:0000255
TgeneAKAP9chr7:91630522chr7:91622250ENST000003581000491422_144703858.0Coiled coilOntology_term=ECO:0000255
TgeneAKAP9chr7:91630522chr7:91622250ENST00000358100049152_90203858.0Coiled coilOntology_term=ECO:0000255
TgeneAKAP9chr7:91630522chr7:91622250ENST000003581000491573_164703858.0Coiled coilOntology_term=ECO:0000255
TgeneAKAP9chr7:91630522chr7:91622250ENST000003581000491845_244303858.0Coiled coilOntology_term=ECO:0000255
TgeneAKAP9chr7:91630522chr7:91622250ENST000003581000492532_254903858.0Coiled coilOntology_term=ECO:0000255
TgeneAKAP9chr7:91630522chr7:91622250ENST000003581000492591_276403858.0Coiled coilOntology_term=ECO:0000255
TgeneAKAP9chr7:91630522chr7:91622250ENST000003581000493061_308803858.0Coiled coilOntology_term=ECO:0000255
TgeneAKAP9chr7:91630522chr7:91622250ENST000003581000493120_346603858.0Coiled coilOntology_term=ECO:0000255
TgeneAKAP9chr7:91630522chr7:91622250ENST000003581000493583_368503858.0Coiled coilOntology_term=ECO:0000255
TgeneAKAP9chr7:91630522chr7:91622250ENST00000358100049932_101003858.0Coiled coilOntology_term=ECO:0000255
TgeneAKAP9chr7:91630522chr7:91622250ENST000003590280501088_117303912.0Coiled coilOntology_term=ECO:0000255
TgeneAKAP9chr7:91630522chr7:91622250ENST000003590280501241_126803912.0Coiled coilOntology_term=ECO:0000255
TgeneAKAP9chr7:91630522chr7:91622250ENST000003590280501324_138003912.0Coiled coilOntology_term=ECO:0000255
TgeneAKAP9chr7:91630522chr7:91622250ENST000003590280501422_144703912.0Coiled coilOntology_term=ECO:0000255
TgeneAKAP9chr7:91630522chr7:91622250ENST00000359028050152_90203912.0Coiled coilOntology_term=ECO:0000255
TgeneAKAP9chr7:91630522chr7:91622250ENST000003590280501573_164703912.0Coiled coilOntology_term=ECO:0000255
TgeneAKAP9chr7:91630522chr7:91622250ENST000003590280501845_244303912.0Coiled coilOntology_term=ECO:0000255
TgeneAKAP9chr7:91630522chr7:91622250ENST000003590280502532_254903912.0Coiled coilOntology_term=ECO:0000255
TgeneAKAP9chr7:91630522chr7:91622250ENST000003590280502591_276403912.0Coiled coilOntology_term=ECO:0000255
TgeneAKAP9chr7:91630522chr7:91622250ENST000003590280503061_308803912.0Coiled coilOntology_term=ECO:0000255
TgeneAKAP9chr7:91630522chr7:91622250ENST000003590280503120_346603912.0Coiled coilOntology_term=ECO:0000255
TgeneAKAP9chr7:91630522chr7:91622250ENST000003590280503583_368503912.0Coiled coilOntology_term=ECO:0000255
TgeneAKAP9chr7:91630522chr7:91622250ENST00000359028050932_101003912.0Coiled coilOntology_term=ECO:0000255
TgeneAKAP9chr7:91630522chr7:91622250ENST000003562390501834_276003908.0Compositional biasNote=Glu-rich
TgeneAKAP9chr7:91630522chr7:91622250ENST00000356239050191_28003908.0Compositional biasNote=Gln-rich
TgeneAKAP9chr7:91630522chr7:91622250ENST00000356239050309_99803908.0Compositional biasNote=Glu-rich
TgeneAKAP9chr7:91630522chr7:91622250ENST000003562390503722_372603908.0Compositional biasNote=Poly-Leu
TgeneAKAP9chr7:91630522chr7:91622250ENST000003581000491834_276003858.0Compositional biasNote=Glu-rich
TgeneAKAP9chr7:91630522chr7:91622250ENST00000358100049191_28003858.0Compositional biasNote=Gln-rich
TgeneAKAP9chr7:91630522chr7:91622250ENST00000358100049309_99803858.0Compositional biasNote=Glu-rich
TgeneAKAP9chr7:91630522chr7:91622250ENST000003581000493722_372603858.0Compositional biasNote=Poly-Leu
TgeneAKAP9chr7:91630522chr7:91622250ENST000003590280501834_276003912.0Compositional biasNote=Glu-rich
TgeneAKAP9chr7:91630522chr7:91622250ENST00000359028050191_28003912.0Compositional biasNote=Gln-rich
TgeneAKAP9chr7:91630522chr7:91622250ENST00000359028050309_99803912.0Compositional biasNote=Glu-rich
TgeneAKAP9chr7:91630522chr7:91622250ENST000003590280503722_372603912.0Compositional biasNote=Poly-Leu
TgeneAKAP9chr7:91630522chr7:91622250ENST000003562390502542_255503908.0RegionNote=PKA-RII subunit binding domain
TgeneAKAP9chr7:91630522chr7:91622250ENST000003581000492542_255503858.0RegionNote=PKA-RII subunit binding domain
TgeneAKAP9chr7:91630522chr7:91622250ENST000003590280502542_255503912.0RegionNote=PKA-RII subunit binding domain

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneAKAP9chr7:91630522chr7:91622250ENST00000356239+1501088_117303908.0Coiled coilOntology_term=ECO:0000255
HgeneAKAP9chr7:91630522chr7:91622250ENST00000356239+1501241_126803908.0Coiled coilOntology_term=ECO:0000255
HgeneAKAP9chr7:91630522chr7:91622250ENST00000356239+1501324_138003908.0Coiled coilOntology_term=ECO:0000255
HgeneAKAP9chr7:91630522chr7:91622250ENST00000356239+1501422_144703908.0Coiled coilOntology_term=ECO:0000255
HgeneAKAP9chr7:91630522chr7:91622250ENST00000356239+150152_90203908.0Coiled coilOntology_term=ECO:0000255
HgeneAKAP9chr7:91630522chr7:91622250ENST00000356239+1501573_164703908.0Coiled coilOntology_term=ECO:0000255
HgeneAKAP9chr7:91630522chr7:91622250ENST00000356239+1501845_244303908.0Coiled coilOntology_term=ECO:0000255
HgeneAKAP9chr7:91630522chr7:91622250ENST00000356239+1502532_254903908.0Coiled coilOntology_term=ECO:0000255
HgeneAKAP9chr7:91630522chr7:91622250ENST00000356239+1502591_276403908.0Coiled coilOntology_term=ECO:0000255
HgeneAKAP9chr7:91630522chr7:91622250ENST00000356239+1503061_308803908.0Coiled coilOntology_term=ECO:0000255
HgeneAKAP9chr7:91630522chr7:91622250ENST00000356239+1503120_346603908.0Coiled coilOntology_term=ECO:0000255
HgeneAKAP9chr7:91630522chr7:91622250ENST00000356239+1503583_368503908.0Coiled coilOntology_term=ECO:0000255
HgeneAKAP9chr7:91630522chr7:91622250ENST00000356239+150932_101003908.0Coiled coilOntology_term=ECO:0000255
HgeneAKAP9chr7:91630522chr7:91622250ENST00000358100+1491088_117303858.0Coiled coilOntology_term=ECO:0000255
HgeneAKAP9chr7:91630522chr7:91622250ENST00000358100+1491241_126803858.0Coiled coilOntology_term=ECO:0000255
HgeneAKAP9chr7:91630522chr7:91622250ENST00000358100+1491324_138003858.0Coiled coilOntology_term=ECO:0000255
HgeneAKAP9chr7:91630522chr7:91622250ENST00000358100+1491422_144703858.0Coiled coilOntology_term=ECO:0000255
HgeneAKAP9chr7:91630522chr7:91622250ENST00000358100+149152_90203858.0Coiled coilOntology_term=ECO:0000255
HgeneAKAP9chr7:91630522chr7:91622250ENST00000358100+1491573_164703858.0Coiled coilOntology_term=ECO:0000255
HgeneAKAP9chr7:91630522chr7:91622250ENST00000358100+1491845_244303858.0Coiled coilOntology_term=ECO:0000255
HgeneAKAP9chr7:91630522chr7:91622250ENST00000358100+1492532_254903858.0Coiled coilOntology_term=ECO:0000255
HgeneAKAP9chr7:91630522chr7:91622250ENST00000358100+1492591_276403858.0Coiled coilOntology_term=ECO:0000255
HgeneAKAP9chr7:91630522chr7:91622250ENST00000358100+1493061_308803858.0Coiled coilOntology_term=ECO:0000255
HgeneAKAP9chr7:91630522chr7:91622250ENST00000358100+1493120_346603858.0Coiled coilOntology_term=ECO:0000255
HgeneAKAP9chr7:91630522chr7:91622250ENST00000358100+1493583_368503858.0Coiled coilOntology_term=ECO:0000255
HgeneAKAP9chr7:91630522chr7:91622250ENST00000358100+149932_101003858.0Coiled coilOntology_term=ECO:0000255
HgeneAKAP9chr7:91630522chr7:91622250ENST00000359028+1501088_117303912.0Coiled coilOntology_term=ECO:0000255
HgeneAKAP9chr7:91630522chr7:91622250ENST00000359028+1501241_126803912.0Coiled coilOntology_term=ECO:0000255
HgeneAKAP9chr7:91630522chr7:91622250ENST00000359028+1501324_138003912.0Coiled coilOntology_term=ECO:0000255
HgeneAKAP9chr7:91630522chr7:91622250ENST00000359028+1501422_144703912.0Coiled coilOntology_term=ECO:0000255
HgeneAKAP9chr7:91630522chr7:91622250ENST00000359028+150152_90203912.0Coiled coilOntology_term=ECO:0000255
HgeneAKAP9chr7:91630522chr7:91622250ENST00000359028+1501573_164703912.0Coiled coilOntology_term=ECO:0000255
HgeneAKAP9chr7:91630522chr7:91622250ENST00000359028+1501845_244303912.0Coiled coilOntology_term=ECO:0000255
HgeneAKAP9chr7:91630522chr7:91622250ENST00000359028+1502532_254903912.0Coiled coilOntology_term=ECO:0000255
HgeneAKAP9chr7:91630522chr7:91622250ENST00000359028+1502591_276403912.0Coiled coilOntology_term=ECO:0000255
HgeneAKAP9chr7:91630522chr7:91622250ENST00000359028+1503061_308803912.0Coiled coilOntology_term=ECO:0000255
HgeneAKAP9chr7:91630522chr7:91622250ENST00000359028+1503120_346603912.0Coiled coilOntology_term=ECO:0000255
HgeneAKAP9chr7:91630522chr7:91622250ENST00000359028+1503583_368503912.0Coiled coilOntology_term=ECO:0000255
HgeneAKAP9chr7:91630522chr7:91622250ENST00000359028+150932_101003912.0Coiled coilOntology_term=ECO:0000255
HgeneAKAP9chr7:91630522chr7:91622250ENST00000356239+1501834_276003908.0Compositional biasNote=Glu-rich
HgeneAKAP9chr7:91630522chr7:91622250ENST00000356239+150191_28003908.0Compositional biasNote=Gln-rich
HgeneAKAP9chr7:91630522chr7:91622250ENST00000356239+150309_99803908.0Compositional biasNote=Glu-rich
HgeneAKAP9chr7:91630522chr7:91622250ENST00000356239+1503722_372603908.0Compositional biasNote=Poly-Leu
HgeneAKAP9chr7:91630522chr7:91622250ENST00000358100+1491834_276003858.0Compositional biasNote=Glu-rich
HgeneAKAP9chr7:91630522chr7:91622250ENST00000358100+149191_28003858.0Compositional biasNote=Gln-rich
HgeneAKAP9chr7:91630522chr7:91622250ENST00000358100+149309_99803858.0Compositional biasNote=Glu-rich
HgeneAKAP9chr7:91630522chr7:91622250ENST00000358100+1493722_372603858.0Compositional biasNote=Poly-Leu
HgeneAKAP9chr7:91630522chr7:91622250ENST00000359028+1501834_276003912.0Compositional biasNote=Glu-rich
HgeneAKAP9chr7:91630522chr7:91622250ENST00000359028+150191_28003912.0Compositional biasNote=Gln-rich
HgeneAKAP9chr7:91630522chr7:91622250ENST00000359028+150309_99803912.0Compositional biasNote=Glu-rich
HgeneAKAP9chr7:91630522chr7:91622250ENST00000359028+1503722_372603912.0Compositional biasNote=Poly-Leu
HgeneAKAP9chr7:91630522chr7:91622250ENST00000356239+1502542_255503908.0RegionNote=PKA-RII subunit binding domain
HgeneAKAP9chr7:91630522chr7:91622250ENST00000358100+1492542_255503858.0RegionNote=PKA-RII subunit binding domain
HgeneAKAP9chr7:91630522chr7:91622250ENST00000359028+1502542_255503912.0RegionNote=PKA-RII subunit binding domain


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Fusion Gene Sequence for AKAP9-AKAP9


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for AKAP9-AKAP9


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for AKAP9-AKAP9


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for AKAP9-AKAP9


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneAKAP9C2678483Long Qt Syndrome 114CLINGEN;CTD_human;GENOMICS_ENGLAND;UNIPROT
HgeneAKAP9C0035828Romano-Ward Syndrome1ORPHANET
HgeneAKAP9C0037274Dermatologic disorders1CTD_human
HgeneAKAP9C0274861Arsenic Poisoning, Inorganic1CTD_human
HgeneAKAP9C0274862Nervous System, Organic Arsenic Poisoning1CTD_human
HgeneAKAP9C0311375Arsenic Poisoning1CTD_human
HgeneAKAP9C0751851Arsenic Encephalopathy1CTD_human
HgeneAKAP9C0751852Arsenic Induced Polyneuropathy1CTD_human
HgeneAKAP9C1142166Brugada Syndrome (disorder)1ORPHANET
TgeneC2678483Long Qt Syndrome 114CLINGEN;CTD_human;GENOMICS_ENGLAND;UNIPROT
TgeneC0035828Romano-Ward Syndrome1ORPHANET
TgeneC0037274Dermatologic disorders1CTD_human
TgeneC0274861Arsenic Poisoning, Inorganic1CTD_human
TgeneC0274862Nervous System, Organic Arsenic Poisoning1CTD_human
TgeneC0311375Arsenic Poisoning1CTD_human
TgeneC0751851Arsenic Encephalopathy1CTD_human
TgeneC0751852Arsenic Induced Polyneuropathy1CTD_human
TgeneC1142166Brugada Syndrome (disorder)1ORPHANET