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![]() | Fusion Gene Summary |
![]() | Fusion Gene ORF analysis |
![]() | Fusion Genomic Features |
![]() | Fusion Protein Features |
![]() | Fusion Gene Sequence |
![]() | Fusion Gene PPI analysis |
![]() | Related Drugs |
![]() | Related Diseases |
Fusion gene:ABI2-CYP20A1 (FusionGDB2 ID:HG10152TG57404) |
Fusion Gene Summary for ABI2-CYP20A1 |
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Fusion gene information | Fusion gene name: ABI2-CYP20A1 | Fusion gene ID: hg10152tg57404 | Hgene | Tgene | Gene symbol | ABI2 | CYP20A1 | Gene ID | 10152 | 57404 |
Gene name | abl interactor 2 | cytochrome P450 family 20 subfamily A member 1 | |
Synonyms | ABI-2|ABI2B|AIP-1|AIP1|AblBP3|SSH3BP2|argBP1|argBPIA|argBPIB | CYP-M | |
Cytomap | ('ABI2')('CYP20A1') 2q33.2 | 2q33.2 | |
Type of gene | protein-coding | protein-coding | |
Description | abl interactor 2abelson interactor 2abl binding protein 3abl-interacting protein 1 (SH3-containing protein)abl-interactor protein 2barg protein tyrosine kinase-binding proteinarg-binding protein 1 | cytochrome P450 20A1cytochrome P450 monooxygenasecytochrome P450, family 20, subfamily A, polypeptide 1 | |
Modification date | 20200327 | 20200313 | |
UniProtAcc | Q9NYB9 | . | |
Ensembl transtripts involved in fusion gene | ENST00000261016, ENST00000261017, ENST00000295851, ENST00000422511, ENST00000424558, ENST00000430418, ENST00000261018, ENST00000430574, | ENST00000261016, ENST00000261017, ENST00000295851, ENST00000422511, ENST00000424558, ENST00000430418, ENST00000261018, ENST00000430574, | |
Fusion gene scores | * DoF score | 14 X 7 X 8=784 | 8 X 11 X 5=440 |
# samples | 17 | 9 | |
** MAII score | log2(17/784*10)=-2.20531890797751 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(9/440*10)=-2.28950661719499 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: ABI2 [Title/Abstract] AND CYP20A1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Most frequent breakpoint | ABI2(204193354)-CYP20A1(204154488), # samples:2 | ||
Anticipated loss of major functional domain due to fusion event. | ABI2-CYP20A1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. ABI2-CYP20A1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. CYP20A1-ABI2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. CYP20A1-ABI2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. ABI2-CYP20A1 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF. ABI2-CYP20A1 seems lost the major protein functional domain in Hgene partner, which is a tumor suppressor due to the frame-shifted ORF. ABI2-CYP20A1 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | ABI2 | GO:0016601 | Rac protein signal transduction | 21107423 |
Hgene | ABI2 | GO:0018108 | peptidyl-tyrosine phosphorylation | 17101133 |
Hgene | ABI2 | GO:2000601 | positive regulation of Arp2/3 complex-mediated actin nucleation | 21107423 |
![]() * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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![]() * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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![]() * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChimerDB4 | BRCA | TCGA-A7-A26G-01A | ABI2 | chr2 | 204193354 | + | CYP20A1 | chr2 | 204154488 | + |
ChimerDB4 | BRCA | TCGA-A7-A26G-01A | ABI2 | chr2 | 204231767 | + | CYP20A1 | chr2 | 204161197 | + |
ChimerDB4 | BRCA | TCGA-A7-A26G-01A | ABI2 | chr2 | 204231767 | + | CYP20A1 | chr2 | 204161481 | + |
ChimerDB4 | OV | TCGA-13-0908-01B | ABI2 | chr2 | 204193354 | + | CYP20A1 | chr2 | 204156985 | + |
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Fusion Gene ORF analysis for ABI2-CYP20A1 |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5CDS-3UTR | ENST00000261016 | ENST00000429815 | ABI2 | chr2 | 204231767 | + | CYP20A1 | chr2 | 204161197 | + |
5CDS-3UTR | ENST00000261016 | ENST00000429815 | ABI2 | chr2 | 204231767 | + | CYP20A1 | chr2 | 204161481 | + |
5CDS-3UTR | ENST00000261016 | ENST00000461371 | ABI2 | chr2 | 204231767 | + | CYP20A1 | chr2 | 204161197 | + |
5CDS-3UTR | ENST00000261016 | ENST00000461371 | ABI2 | chr2 | 204231767 | + | CYP20A1 | chr2 | 204161481 | + |
5CDS-3UTR | ENST00000261017 | ENST00000429815 | ABI2 | chr2 | 204193354 | + | CYP20A1 | chr2 | 204154488 | + |
5CDS-3UTR | ENST00000261017 | ENST00000429815 | ABI2 | chr2 | 204231767 | + | CYP20A1 | chr2 | 204161197 | + |
5CDS-3UTR | ENST00000261017 | ENST00000429815 | ABI2 | chr2 | 204231767 | + | CYP20A1 | chr2 | 204161481 | + |
5CDS-3UTR | ENST00000261017 | ENST00000429815 | ABI2 | chr2 | 204193354 | + | CYP20A1 | chr2 | 204156985 | + |
5CDS-3UTR | ENST00000261017 | ENST00000461371 | ABI2 | chr2 | 204193354 | + | CYP20A1 | chr2 | 204154488 | + |
5CDS-3UTR | ENST00000261017 | ENST00000461371 | ABI2 | chr2 | 204231767 | + | CYP20A1 | chr2 | 204161197 | + |
5CDS-3UTR | ENST00000261017 | ENST00000461371 | ABI2 | chr2 | 204231767 | + | CYP20A1 | chr2 | 204161481 | + |
5CDS-3UTR | ENST00000261017 | ENST00000461371 | ABI2 | chr2 | 204193354 | + | CYP20A1 | chr2 | 204156985 | + |
5CDS-3UTR | ENST00000295851 | ENST00000429815 | ABI2 | chr2 | 204193354 | + | CYP20A1 | chr2 | 204154488 | + |
5CDS-3UTR | ENST00000295851 | ENST00000429815 | ABI2 | chr2 | 204231767 | + | CYP20A1 | chr2 | 204161197 | + |
5CDS-3UTR | ENST00000295851 | ENST00000429815 | ABI2 | chr2 | 204231767 | + | CYP20A1 | chr2 | 204161481 | + |
5CDS-3UTR | ENST00000295851 | ENST00000429815 | ABI2 | chr2 | 204193354 | + | CYP20A1 | chr2 | 204156985 | + |
5CDS-3UTR | ENST00000295851 | ENST00000461371 | ABI2 | chr2 | 204193354 | + | CYP20A1 | chr2 | 204154488 | + |
5CDS-3UTR | ENST00000295851 | ENST00000461371 | ABI2 | chr2 | 204231767 | + | CYP20A1 | chr2 | 204161197 | + |
5CDS-3UTR | ENST00000295851 | ENST00000461371 | ABI2 | chr2 | 204231767 | + | CYP20A1 | chr2 | 204161481 | + |
5CDS-3UTR | ENST00000295851 | ENST00000461371 | ABI2 | chr2 | 204193354 | + | CYP20A1 | chr2 | 204156985 | + |
5CDS-3UTR | ENST00000422511 | ENST00000429815 | ABI2 | chr2 | 204193354 | + | CYP20A1 | chr2 | 204154488 | + |
5CDS-3UTR | ENST00000422511 | ENST00000429815 | ABI2 | chr2 | 204231767 | + | CYP20A1 | chr2 | 204161197 | + |
5CDS-3UTR | ENST00000422511 | ENST00000429815 | ABI2 | chr2 | 204231767 | + | CYP20A1 | chr2 | 204161481 | + |
5CDS-3UTR | ENST00000422511 | ENST00000429815 | ABI2 | chr2 | 204193354 | + | CYP20A1 | chr2 | 204156985 | + |
5CDS-3UTR | ENST00000422511 | ENST00000461371 | ABI2 | chr2 | 204193354 | + | CYP20A1 | chr2 | 204154488 | + |
5CDS-3UTR | ENST00000422511 | ENST00000461371 | ABI2 | chr2 | 204231767 | + | CYP20A1 | chr2 | 204161197 | + |
5CDS-3UTR | ENST00000422511 | ENST00000461371 | ABI2 | chr2 | 204231767 | + | CYP20A1 | chr2 | 204161481 | + |
5CDS-3UTR | ENST00000422511 | ENST00000461371 | ABI2 | chr2 | 204193354 | + | CYP20A1 | chr2 | 204156985 | + |
5CDS-3UTR | ENST00000424558 | ENST00000429815 | ABI2 | chr2 | 204193354 | + | CYP20A1 | chr2 | 204154488 | + |
5CDS-3UTR | ENST00000424558 | ENST00000429815 | ABI2 | chr2 | 204231767 | + | CYP20A1 | chr2 | 204161197 | + |
5CDS-3UTR | ENST00000424558 | ENST00000429815 | ABI2 | chr2 | 204231767 | + | CYP20A1 | chr2 | 204161481 | + |
5CDS-3UTR | ENST00000424558 | ENST00000429815 | ABI2 | chr2 | 204193354 | + | CYP20A1 | chr2 | 204156985 | + |
5CDS-3UTR | ENST00000424558 | ENST00000461371 | ABI2 | chr2 | 204193354 | + | CYP20A1 | chr2 | 204154488 | + |
5CDS-3UTR | ENST00000424558 | ENST00000461371 | ABI2 | chr2 | 204231767 | + | CYP20A1 | chr2 | 204161197 | + |
5CDS-3UTR | ENST00000424558 | ENST00000461371 | ABI2 | chr2 | 204231767 | + | CYP20A1 | chr2 | 204161481 | + |
5CDS-3UTR | ENST00000424558 | ENST00000461371 | ABI2 | chr2 | 204193354 | + | CYP20A1 | chr2 | 204156985 | + |
5CDS-3UTR | ENST00000430418 | ENST00000429815 | ABI2 | chr2 | 204193354 | + | CYP20A1 | chr2 | 204154488 | + |
5CDS-3UTR | ENST00000430418 | ENST00000429815 | ABI2 | chr2 | 204231767 | + | CYP20A1 | chr2 | 204161197 | + |
5CDS-3UTR | ENST00000430418 | ENST00000429815 | ABI2 | chr2 | 204231767 | + | CYP20A1 | chr2 | 204161481 | + |
5CDS-3UTR | ENST00000430418 | ENST00000429815 | ABI2 | chr2 | 204193354 | + | CYP20A1 | chr2 | 204156985 | + |
5CDS-3UTR | ENST00000430418 | ENST00000461371 | ABI2 | chr2 | 204193354 | + | CYP20A1 | chr2 | 204154488 | + |
5CDS-3UTR | ENST00000430418 | ENST00000461371 | ABI2 | chr2 | 204231767 | + | CYP20A1 | chr2 | 204161197 | + |
5CDS-3UTR | ENST00000430418 | ENST00000461371 | ABI2 | chr2 | 204231767 | + | CYP20A1 | chr2 | 204161481 | + |
5CDS-3UTR | ENST00000430418 | ENST00000461371 | ABI2 | chr2 | 204193354 | + | CYP20A1 | chr2 | 204156985 | + |
5UTR-3CDS | ENST00000261016 | ENST00000356079 | ABI2 | chr2 | 204193354 | + | CYP20A1 | chr2 | 204154488 | + |
5UTR-3CDS | ENST00000261016 | ENST00000356079 | ABI2 | chr2 | 204193354 | + | CYP20A1 | chr2 | 204156985 | + |
5UTR-3UTR | ENST00000261016 | ENST00000429815 | ABI2 | chr2 | 204193354 | + | CYP20A1 | chr2 | 204154488 | + |
5UTR-3UTR | ENST00000261016 | ENST00000429815 | ABI2 | chr2 | 204193354 | + | CYP20A1 | chr2 | 204156985 | + |
5UTR-3UTR | ENST00000261016 | ENST00000461371 | ABI2 | chr2 | 204193354 | + | CYP20A1 | chr2 | 204154488 | + |
5UTR-3UTR | ENST00000261016 | ENST00000461371 | ABI2 | chr2 | 204193354 | + | CYP20A1 | chr2 | 204156985 | + |
Frame-shift | ENST00000261016 | ENST00000356079 | ABI2 | chr2 | 204231767 | + | CYP20A1 | chr2 | 204161481 | + |
Frame-shift | ENST00000261017 | ENST00000356079 | ABI2 | chr2 | 204193354 | + | CYP20A1 | chr2 | 204154488 | + |
Frame-shift | ENST00000261017 | ENST00000356079 | ABI2 | chr2 | 204231767 | + | CYP20A1 | chr2 | 204161197 | + |
Frame-shift | ENST00000261017 | ENST00000356079 | ABI2 | chr2 | 204231767 | + | CYP20A1 | chr2 | 204161481 | + |
Frame-shift | ENST00000295851 | ENST00000356079 | ABI2 | chr2 | 204193354 | + | CYP20A1 | chr2 | 204154488 | + |
Frame-shift | ENST00000295851 | ENST00000356079 | ABI2 | chr2 | 204231767 | + | CYP20A1 | chr2 | 204161197 | + |
Frame-shift | ENST00000295851 | ENST00000356079 | ABI2 | chr2 | 204231767 | + | CYP20A1 | chr2 | 204161481 | + |
Frame-shift | ENST00000422511 | ENST00000356079 | ABI2 | chr2 | 204193354 | + | CYP20A1 | chr2 | 204154488 | + |
Frame-shift | ENST00000422511 | ENST00000356079 | ABI2 | chr2 | 204231767 | + | CYP20A1 | chr2 | 204161197 | + |
Frame-shift | ENST00000422511 | ENST00000356079 | ABI2 | chr2 | 204231767 | + | CYP20A1 | chr2 | 204161481 | + |
Frame-shift | ENST00000424558 | ENST00000356079 | ABI2 | chr2 | 204193354 | + | CYP20A1 | chr2 | 204154488 | + |
Frame-shift | ENST00000424558 | ENST00000356079 | ABI2 | chr2 | 204231767 | + | CYP20A1 | chr2 | 204161197 | + |
Frame-shift | ENST00000424558 | ENST00000356079 | ABI2 | chr2 | 204231767 | + | CYP20A1 | chr2 | 204161481 | + |
Frame-shift | ENST00000430418 | ENST00000356079 | ABI2 | chr2 | 204193354 | + | CYP20A1 | chr2 | 204154488 | + |
Frame-shift | ENST00000430418 | ENST00000356079 | ABI2 | chr2 | 204231767 | + | CYP20A1 | chr2 | 204161197 | + |
Frame-shift | ENST00000430418 | ENST00000356079 | ABI2 | chr2 | 204231767 | + | CYP20A1 | chr2 | 204161481 | + |
In-frame | ENST00000261016 | ENST00000356079 | ABI2 | chr2 | 204231767 | + | CYP20A1 | chr2 | 204161197 | + |
In-frame | ENST00000261017 | ENST00000356079 | ABI2 | chr2 | 204193354 | + | CYP20A1 | chr2 | 204156985 | + |
In-frame | ENST00000295851 | ENST00000356079 | ABI2 | chr2 | 204193354 | + | CYP20A1 | chr2 | 204156985 | + |
In-frame | ENST00000422511 | ENST00000356079 | ABI2 | chr2 | 204193354 | + | CYP20A1 | chr2 | 204156985 | + |
In-frame | ENST00000424558 | ENST00000356079 | ABI2 | chr2 | 204193354 | + | CYP20A1 | chr2 | 204156985 | + |
In-frame | ENST00000430418 | ENST00000356079 | ABI2 | chr2 | 204193354 | + | CYP20A1 | chr2 | 204156985 | + |
intron-3CDS | ENST00000261018 | ENST00000356079 | ABI2 | chr2 | 204193354 | + | CYP20A1 | chr2 | 204154488 | + |
intron-3CDS | ENST00000261018 | ENST00000356079 | ABI2 | chr2 | 204231767 | + | CYP20A1 | chr2 | 204161197 | + |
intron-3CDS | ENST00000261018 | ENST00000356079 | ABI2 | chr2 | 204231767 | + | CYP20A1 | chr2 | 204161481 | + |
intron-3CDS | ENST00000261018 | ENST00000356079 | ABI2 | chr2 | 204193354 | + | CYP20A1 | chr2 | 204156985 | + |
intron-3CDS | ENST00000430574 | ENST00000356079 | ABI2 | chr2 | 204193354 | + | CYP20A1 | chr2 | 204154488 | + |
intron-3CDS | ENST00000430574 | ENST00000356079 | ABI2 | chr2 | 204231767 | + | CYP20A1 | chr2 | 204161197 | + |
intron-3CDS | ENST00000430574 | ENST00000356079 | ABI2 | chr2 | 204231767 | + | CYP20A1 | chr2 | 204161481 | + |
intron-3CDS | ENST00000430574 | ENST00000356079 | ABI2 | chr2 | 204193354 | + | CYP20A1 | chr2 | 204156985 | + |
intron-3UTR | ENST00000261018 | ENST00000429815 | ABI2 | chr2 | 204193354 | + | CYP20A1 | chr2 | 204154488 | + |
intron-3UTR | ENST00000261018 | ENST00000429815 | ABI2 | chr2 | 204231767 | + | CYP20A1 | chr2 | 204161197 | + |
intron-3UTR | ENST00000261018 | ENST00000429815 | ABI2 | chr2 | 204231767 | + | CYP20A1 | chr2 | 204161481 | + |
intron-3UTR | ENST00000261018 | ENST00000429815 | ABI2 | chr2 | 204193354 | + | CYP20A1 | chr2 | 204156985 | + |
intron-3UTR | ENST00000261018 | ENST00000461371 | ABI2 | chr2 | 204193354 | + | CYP20A1 | chr2 | 204154488 | + |
intron-3UTR | ENST00000261018 | ENST00000461371 | ABI2 | chr2 | 204231767 | + | CYP20A1 | chr2 | 204161197 | + |
intron-3UTR | ENST00000261018 | ENST00000461371 | ABI2 | chr2 | 204231767 | + | CYP20A1 | chr2 | 204161481 | + |
intron-3UTR | ENST00000261018 | ENST00000461371 | ABI2 | chr2 | 204193354 | + | CYP20A1 | chr2 | 204156985 | + |
intron-3UTR | ENST00000430574 | ENST00000429815 | ABI2 | chr2 | 204193354 | + | CYP20A1 | chr2 | 204154488 | + |
intron-3UTR | ENST00000430574 | ENST00000429815 | ABI2 | chr2 | 204231767 | + | CYP20A1 | chr2 | 204161197 | + |
intron-3UTR | ENST00000430574 | ENST00000429815 | ABI2 | chr2 | 204231767 | + | CYP20A1 | chr2 | 204161481 | + |
intron-3UTR | ENST00000430574 | ENST00000429815 | ABI2 | chr2 | 204193354 | + | CYP20A1 | chr2 | 204156985 | + |
intron-3UTR | ENST00000430574 | ENST00000461371 | ABI2 | chr2 | 204193354 | + | CYP20A1 | chr2 | 204154488 | + |
intron-3UTR | ENST00000430574 | ENST00000461371 | ABI2 | chr2 | 204231767 | + | CYP20A1 | chr2 | 204161197 | + |
intron-3UTR | ENST00000430574 | ENST00000461371 | ABI2 | chr2 | 204231767 | + | CYP20A1 | chr2 | 204161481 | + |
intron-3UTR | ENST00000430574 | ENST00000461371 | ABI2 | chr2 | 204193354 | + | CYP20A1 | chr2 | 204156985 | + |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
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Fusion Genomic Features for ABI2-CYP20A1 |
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Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
ABI2 | chr2 | 204193354 | + | CYP20A1 | chr2 | 204154487 | + | 1.60E-12 | 1 |
ABI2 | chr2 | 204231767 | + | CYP20A1 | chr2 | 204161196 | + | 4.02E-10 | 1 |
ABI2 | chr2 | 204231767 | + | CYP20A1 | chr2 | 204161480 | + | 3.26E-10 | 1 |
ABI2 | chr2 | 204193354 | + | CYP20A1 | chr2 | 204156984 | + | 8.28E-14 | 1 |
ABI2 | chr2 | 204193354 | + | CYP20A1 | chr2 | 204154487 | + | 1.60E-12 | 1 |
ABI2 | chr2 | 204231767 | + | CYP20A1 | chr2 | 204161196 | + | 4.02E-10 | 1 |
ABI2 | chr2 | 204231767 | + | CYP20A1 | chr2 | 204161480 | + | 3.26E-10 | 1 |
ABI2 | chr2 | 204193354 | + | CYP20A1 | chr2 | 204156984 | + | 8.28E-14 | 1 |
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Fusion Protein Features for ABI2-CYP20A1 |
![]() Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:204193354/chr2:204154488) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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Hgene | Tgene |
ABI2 | . |
FUNCTION: Regulator of actin cytoskeleton dynamics underlying cell motility and adhesion. Functions as a component of the WAVE complex, which activates actin nucleating machinery Arp2/3 to drive lamellipodia formation (PubMed:21107423). Acts as regulator and substrate of nonreceptor tyrosine kinases ABL1 and ABL2 involved in processes linked to cell growth and differentiation. Positively regulates ABL1-mediated phosphorylation of ENAH, which is required for proper polymerization of nucleated actin filaments at the leading edge (PubMed:7590236, PubMed:8649853, PubMed:10498863). Contributes to the regulation of actin assembly at the tips of neuron projections. In particular, controls dendritic spine morphogenesis and may promote dendritic spine specification toward large mushroom-type spines known as repositories of memory in the brain (By similarity). In hippocampal neurons, may mediate actin-dependent BDNF-NTRK2 early endocytic trafficking that triggers dendrite outgrowth (By similarity). Participates in ocular lens morphogenesis, likely by regulating lamellipodia-driven adherens junction formation at the epithelial cell-secondary lens fiber interface (By similarity). Also required for nascent adherens junction assembly in epithelial cells (PubMed:15572692). {ECO:0000250|UniProtKB:P62484, ECO:0000269|PubMed:10498863, ECO:0000269|PubMed:15572692, ECO:0000269|PubMed:21107423, ECO:0000269|PubMed:7590236, ECO:0000269|PubMed:8649853}. | FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | ABI2 | chr2:204193354 | chr2:204156985 | ENST00000261016 | + | 1 | 10 | 172_423 | 0 | 402.0 | Compositional bias | Note=Pro-rich |
Hgene | ABI2 | chr2:204193354 | chr2:204156985 | ENST00000261017 | + | 1 | 10 | 172_423 | 39 | 476.0 | Compositional bias | Note=Pro-rich |
Hgene | ABI2 | chr2:204193354 | chr2:204156985 | ENST00000424558 | + | 1 | 10 | 172_423 | 39 | 508.0 | Compositional bias | Note=Pro-rich |
Hgene | ABI2 | chr2:204231767 | chr2:204161197 | ENST00000261016 | + | 2 | 10 | 172_423 | 24 | 402.0 | Compositional bias | Note=Pro-rich |
Hgene | ABI2 | chr2:204231767 | chr2:204161197 | ENST00000261017 | + | 2 | 10 | 172_423 | 95 | 476.0 | Compositional bias | Note=Pro-rich |
Hgene | ABI2 | chr2:204231767 | chr2:204161197 | ENST00000424558 | + | 2 | 10 | 172_423 | 95 | 508.0 | Compositional bias | Note=Pro-rich |
Hgene | ABI2 | chr2:204193354 | chr2:204156985 | ENST00000261016 | + | 1 | 10 | 451_510 | 0 | 402.0 | Domain | SH3 |
Hgene | ABI2 | chr2:204193354 | chr2:204156985 | ENST00000261016 | + | 1 | 10 | 45_107 | 0 | 402.0 | Domain | t-SNARE coiled-coil homology |
Hgene | ABI2 | chr2:204193354 | chr2:204156985 | ENST00000261017 | + | 1 | 10 | 451_510 | 39 | 476.0 | Domain | SH3 |
Hgene | ABI2 | chr2:204193354 | chr2:204156985 | ENST00000261017 | + | 1 | 10 | 45_107 | 39 | 476.0 | Domain | t-SNARE coiled-coil homology |
Hgene | ABI2 | chr2:204193354 | chr2:204156985 | ENST00000424558 | + | 1 | 10 | 451_510 | 39 | 508.0 | Domain | SH3 |
Hgene | ABI2 | chr2:204193354 | chr2:204156985 | ENST00000424558 | + | 1 | 10 | 45_107 | 39 | 508.0 | Domain | t-SNARE coiled-coil homology |
Hgene | ABI2 | chr2:204231767 | chr2:204161197 | ENST00000261016 | + | 2 | 10 | 451_510 | 24 | 402.0 | Domain | SH3 |
Hgene | ABI2 | chr2:204231767 | chr2:204161197 | ENST00000261016 | + | 2 | 10 | 45_107 | 24 | 402.0 | Domain | t-SNARE coiled-coil homology |
Hgene | ABI2 | chr2:204231767 | chr2:204161197 | ENST00000261017 | + | 2 | 10 | 451_510 | 95 | 476.0 | Domain | SH3 |
Hgene | ABI2 | chr2:204231767 | chr2:204161197 | ENST00000261017 | + | 2 | 10 | 45_107 | 95 | 476.0 | Domain | t-SNARE coiled-coil homology |
Hgene | ABI2 | chr2:204231767 | chr2:204161197 | ENST00000424558 | + | 2 | 10 | 451_510 | 95 | 508.0 | Domain | SH3 |
Hgene | ABI2 | chr2:204231767 | chr2:204161197 | ENST00000424558 | + | 2 | 10 | 45_107 | 95 | 508.0 | Domain | t-SNARE coiled-coil homology |
Tgene | CYP20A1 | chr2:204193354 | chr2:204156985 | ENST00000356079 | 9 | 13 | 4_24 | 361 | 463.0 | Transmembrane | Helical | |
Tgene | CYP20A1 | chr2:204231767 | chr2:204161197 | ENST00000356079 | 10 | 13 | 4_24 | 382 | 463.0 | Transmembrane | Helical |
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Fusion Gene Sequence for ABI2-CYP20A1 |
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Fusion Gene PPI Analysis for ABI2-CYP20A1 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for ABI2-CYP20A1 |
![]() (DrugBank Version 5.1.8 2021-05-08) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for ABI2-CYP20A1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |