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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:FARP1-NME1-NME2 (FusionGDB2 ID:HG10160TG654364)

Fusion Gene Summary for FARP1-NME1-NME2

check button Fusion gene summary
Fusion gene informationFusion gene name: FARP1-NME1-NME2
Fusion gene ID: hg10160tg654364
HgeneTgene
Gene symbol

FARP1

NME1-NME2

Gene ID

10160

654364

Gene nameFERM, ARH/RhoGEF and pleckstrin domain protein 1NME1-NME2 readthrough
SynonymsCDEP|FARP1-IT1|PLEKHC2|PPP1R75NM23-LV|NMELV
Cytomap('FARP1')('NME1-NME2')

13q32.2

17q21.33

Type of geneprotein-codingprotein-coding
DescriptionFERM, ARHGEF and pleckstrin domain-containing protein 1FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived)FERM, RhoGEF and pleckstrin domain-containing protein 1PH domain-containing family C member 2chondrocyte-derived ezrin-liNME1-NME2 proteinNME1-NME2 readthrough transcript
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000319562, ENST00000376581, 
ENST00000376586, ENST00000595437, 
ENST00000593990, 
Fusion gene scores* DoF score19 X 13 X 10=24706 X 7 X 3=126
# samples 227
** MAII scorelog2(22/2470*10)=-3.48893561294738
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(7/126*10)=-0.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: FARP1 [Title/Abstract] AND NME1-NME2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointFARP1(98865667)-NME1-NME2(49237341), # samples:1
Anticipated loss of major functional domain due to fusion event.FARP1-NME1-NME2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
FARP1-NME1-NME2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneFARP1

GO:0010923

negative regulation of phosphatase activity

19389623


check buttonFusion gene breakpoints across FARP1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across NME1-NME2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LGGTCGA-DB-5275-01AFARP1chr13

98865667

-NME1-NME2chr17

49237341

+


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Fusion Gene ORF analysis for FARP1-NME1-NME2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000319562ENST00000393183FARP1chr13

98865667

-NME1-NME2chr17

49237341

+
5CDS-intronENST00000319562ENST00000393185FARP1chr13

98865667

-NME1-NME2chr17

49237341

+
5CDS-intronENST00000319562ENST00000393190FARP1chr13

98865667

-NME1-NME2chr17

49237341

+
5CDS-intronENST00000319562ENST00000503064FARP1chr13

98865667

-NME1-NME2chr17

49237341

+
5CDS-intronENST00000319562ENST00000512737FARP1chr13

98865667

-NME1-NME2chr17

49237341

+
5CDS-intronENST00000319562ENST00000513177FARP1chr13

98865667

-NME1-NME2chr17

49237341

+
5CDS-intronENST00000319562ENST00000514264FARP1chr13

98865667

-NME1-NME2chr17

49237341

+
5CDS-intronENST00000376581ENST00000393183FARP1chr13

98865667

-NME1-NME2chr17

49237341

+
5CDS-intronENST00000376581ENST00000393185FARP1chr13

98865667

-NME1-NME2chr17

49237341

+
5CDS-intronENST00000376581ENST00000393190FARP1chr13

98865667

-NME1-NME2chr17

49237341

+
5CDS-intronENST00000376581ENST00000503064FARP1chr13

98865667

-NME1-NME2chr17

49237341

+
5CDS-intronENST00000376581ENST00000512737FARP1chr13

98865667

-NME1-NME2chr17

49237341

+
5CDS-intronENST00000376581ENST00000513177FARP1chr13

98865667

-NME1-NME2chr17

49237341

+
5CDS-intronENST00000376581ENST00000514264FARP1chr13

98865667

-NME1-NME2chr17

49237341

+
5CDS-intronENST00000376586ENST00000393183FARP1chr13

98865667

-NME1-NME2chr17

49237341

+
5CDS-intronENST00000376586ENST00000393185FARP1chr13

98865667

-NME1-NME2chr17

49237341

+
5CDS-intronENST00000376586ENST00000393190FARP1chr13

98865667

-NME1-NME2chr17

49237341

+
5CDS-intronENST00000376586ENST00000503064FARP1chr13

98865667

-NME1-NME2chr17

49237341

+
5CDS-intronENST00000376586ENST00000512737FARP1chr13

98865667

-NME1-NME2chr17

49237341

+
5CDS-intronENST00000376586ENST00000513177FARP1chr13

98865667

-NME1-NME2chr17

49237341

+
5CDS-intronENST00000376586ENST00000514264FARP1chr13

98865667

-NME1-NME2chr17

49237341

+
5CDS-intronENST00000595437ENST00000393183FARP1chr13

98865667

-NME1-NME2chr17

49237341

+
5CDS-intronENST00000595437ENST00000393185FARP1chr13

98865667

-NME1-NME2chr17

49237341

+
5CDS-intronENST00000595437ENST00000393190FARP1chr13

98865667

-NME1-NME2chr17

49237341

+
5CDS-intronENST00000595437ENST00000503064FARP1chr13

98865667

-NME1-NME2chr17

49237341

+
5CDS-intronENST00000595437ENST00000512737FARP1chr13

98865667

-NME1-NME2chr17

49237341

+
5CDS-intronENST00000595437ENST00000513177FARP1chr13

98865667

-NME1-NME2chr17

49237341

+
5CDS-intronENST00000595437ENST00000514264FARP1chr13

98865667

-NME1-NME2chr17

49237341

+
In-frameENST00000319562ENST00000393198FARP1chr13

98865667

-NME1-NME2chr17

49237341

+
In-frameENST00000319562ENST00000608447FARP1chr13

98865667

-NME1-NME2chr17

49237341

+
In-frameENST00000376581ENST00000393198FARP1chr13

98865667

-NME1-NME2chr17

49237341

+
In-frameENST00000376581ENST00000608447FARP1chr13

98865667

-NME1-NME2chr17

49237341

+
In-frameENST00000376586ENST00000393198FARP1chr13

98865667

-NME1-NME2chr17

49237341

+
In-frameENST00000376586ENST00000608447FARP1chr13

98865667

-NME1-NME2chr17

49237341

+
In-frameENST00000595437ENST00000393198FARP1chr13

98865667

-NME1-NME2chr17

49237341

+
In-frameENST00000595437ENST00000608447FARP1chr13

98865667

-NME1-NME2chr17

49237341

+
intron-3CDSENST00000593990ENST00000393198FARP1chr13

98865667

-NME1-NME2chr17

49237341

+
intron-3CDSENST00000593990ENST00000608447FARP1chr13

98865667

-NME1-NME2chr17

49237341

+
intron-intronENST00000593990ENST00000393183FARP1chr13

98865667

-NME1-NME2chr17

49237341

+
intron-intronENST00000593990ENST00000393185FARP1chr13

98865667

-NME1-NME2chr17

49237341

+
intron-intronENST00000593990ENST00000393190FARP1chr13

98865667

-NME1-NME2chr17

49237341

+
intron-intronENST00000593990ENST00000503064FARP1chr13

98865667

-NME1-NME2chr17

49237341

+
intron-intronENST00000593990ENST00000512737FARP1chr13

98865667

-NME1-NME2chr17

49237341

+
intron-intronENST00000593990ENST00000513177FARP1chr13

98865667

-NME1-NME2chr17

49237341

+
intron-intronENST00000593990ENST00000514264FARP1chr13

98865667

-NME1-NME2chr17

49237341

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000595437FARP1chr1398865667-ENST00000393198NME1-NME2chr1749237341+12274102391087282
ENST00000595437FARP1chr1398865667-ENST00000608447NME1-NME2chr1749237341+12264102391087282
ENST00000376586FARP1chr1398865667-ENST00000393198NME1-NME2chr1749237341+13245073361184282
ENST00000376586FARP1chr1398865667-ENST00000608447NME1-NME2chr1749237341+13235073361184282
ENST00000319562FARP1chr1398865667-ENST00000393198NME1-NME2chr1749237341+12534362651113282
ENST00000319562FARP1chr1398865667-ENST00000608447NME1-NME2chr1749237341+12524362651113282
ENST00000376581FARP1chr1398865667-ENST00000393198NME1-NME2chr1749237341+102420736884282
ENST00000376581FARP1chr1398865667-ENST00000608447NME1-NME2chr1749237341+102320736884282

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000595437ENST00000393198FARP1chr1398865667-NME1-NME2chr1749237341+0.0024866830.9975133
ENST00000595437ENST00000608447FARP1chr1398865667-NME1-NME2chr1749237341+0.0025401110.99745995
ENST00000376586ENST00000393198FARP1chr1398865667-NME1-NME2chr1749237341+0.0019188310.9980812
ENST00000376586ENST00000608447FARP1chr1398865667-NME1-NME2chr1749237341+0.0019446880.99805534
ENST00000319562ENST00000393198FARP1chr1398865667-NME1-NME2chr1749237341+0.0020964220.9979036
ENST00000319562ENST00000608447FARP1chr1398865667-NME1-NME2chr1749237341+0.0021253240.99787474
ENST00000376581ENST00000393198FARP1chr1398865667-NME1-NME2chr1749237341+0.0012570870.998743
ENST00000376581ENST00000608447FARP1chr1398865667-NME1-NME2chr1749237341+0.0012713840.9987286

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Fusion Genomic Features for FARP1-NME1-NME2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

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Fusion Protein Features for FARP1-NME1-NME2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr13:98865667/chr17:49237341)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneFARP1chr13:98865667chr17:49237341ENST00000319562-227449_453571046.0Compositional biasNote=Poly-Glu
HgeneFARP1chr13:98865667chr17:49237341ENST00000376581-23449_45357130.0Compositional biasNote=Poly-Glu
HgeneFARP1chr13:98865667chr17:49237341ENST00000319562-22740_320571046.0DomainFERM
HgeneFARP1chr13:98865667chr17:49237341ENST00000319562-227540_730571046.0DomainDH
HgeneFARP1chr13:98865667chr17:49237341ENST00000319562-227759_856571046.0DomainPH 1
HgeneFARP1chr13:98865667chr17:49237341ENST00000319562-227932_1029571046.0DomainPH 2
HgeneFARP1chr13:98865667chr17:49237341ENST00000376581-2340_32057130.0DomainFERM
HgeneFARP1chr13:98865667chr17:49237341ENST00000376581-23540_73057130.0DomainDH
HgeneFARP1chr13:98865667chr17:49237341ENST00000376581-23759_85657130.0DomainPH 1
HgeneFARP1chr13:98865667chr17:49237341ENST00000376581-23932_102957130.0DomainPH 2


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Fusion Gene Sequence for FARP1-NME1-NME2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>29379_29379_1_FARP1-NME1-NME2_FARP1_chr13_98865667_ENST00000319562_NME1-NME2_chr17_49237341_ENST00000393198_length(transcript)=1253nt_BP=436nt
GCGACCCGGAGCCCGCTCCCCACCCACCCCGCCTGCTCCGCCCTCCCCTCCGCCCCGCGCCACCTTTGATGGCTCGGACCTCAGCCGGCC
ACCGCCAGCCCTGCTCGCGCGCCCGCGCCGCCGCCGCCCGCGGGTATTAATAGCCGGCGCCGCCGCGCCCTCGGCCGCCGGGGGCTTGGG
AGCCGCCGATCCCGGAGCCCGAGCCGGGAGAGGGAGCCGCCGCAGCCGCCGGCGCTGTGGAGATATTCTCTAAGCCGCTTTCATCATGGG
AGAAATAGAGCAGAGGCCGACCCCAGGATCACGACTGGGGGCCCCGGAAAATTCGGGGATCAGTACCTTGGAACGTGGACAGAAGCCGCC
CCCAACACCTTCAGGAAAACTCGTGTCCATCAAAATCCAGATGCTGGATGACACCCAGGAGGCATTTGAAGTTCCAGCTTCCGAAGATCT
TCTCAAGGAACACTACGTTGACCTGAAGGACCGTCCATTCTTTGCCGGCCTGGTGAAATACATGCACTCAGGGCCGGTAGTTGCCATGGT
CTGGGAGGGGCTGAATGTGGTGAAGACGGGCCGAGTCATGCTCGGGGAGACCAACCCTGCAGACTCCAAGCCTGGGACCATCCGTGGAGA
CTTCTGCATACAAGTTGGCAGGACCATGGCCAACCTGGAGCGCACCTTCATCGCCATCAAGCCGGACGGCGTGCAGCGCGGCCTGGTGGG
CGAGATCATCAAGCGCTTCGAGCAGAAGGGATTCCGCCTCGTGGCCATGAAGTTCCTCCGGGCCTCTGAAGAACACCTGAAGCAGCACTA
CATTGACCTGAAAGACCGACCATTCTTCCCTGGGCTGGTGAAGTACATGAACTCAGGGCCGGTTGTGGCCATGGTCTGGGAGGGGCTGAA
CGTGGTGAAGACAGGCCGAGTGATGCTTGGGGAGACCAATCCAGCAGATTCAAAGCCAGGCACCATTCGTGGGGACTTCTGCATTCAGGT
TGGCAGGAACATCATTCATGGCAGTGATTCAGTAAAAAGTGCTGAAAAAGAAATCAGCCTATGGTTTAAGCCTGAAGAACTGGTTGACTA
CAAGTCTTGTGCTCATGACTGGGTCTATGAATAAGAGGTGGACACAACAGCAGTCTCCTTCAGCACGGCGTGGTGTGTCCCTGGACACAG

>29379_29379_1_FARP1-NME1-NME2_FARP1_chr13_98865667_ENST00000319562_NME1-NME2_chr17_49237341_ENST00000393198_length(amino acids)=282AA_BP=128
MGEIEQRPTPGSRLGAPENSGISTLERGQKPPPTPSGKLVSIKIQMLDDTQEAFEVPASEDLLKEHYVDLKDRPFFAGLVKYMHSGPVVA
MVWEGLNVVKTGRVMLGETNPADSKPGTIRGDFCIQVGRTMANLERTFIAIKPDGVQRGLVGEIIKRFEQKGFRLVAMKFLRASEEHLKQ
HYIDLKDRPFFPGLVKYMNSGPVVAMVWEGLNVVKTGRVMLGETNPADSKPGTIRGDFCIQVGRNIIHGSDSVKSAEKEISLWFKPEELV

--------------------------------------------------------------
>29379_29379_2_FARP1-NME1-NME2_FARP1_chr13_98865667_ENST00000319562_NME1-NME2_chr17_49237341_ENST00000608447_length(transcript)=1252nt_BP=436nt
GCGACCCGGAGCCCGCTCCCCACCCACCCCGCCTGCTCCGCCCTCCCCTCCGCCCCGCGCCACCTTTGATGGCTCGGACCTCAGCCGGCC
ACCGCCAGCCCTGCTCGCGCGCCCGCGCCGCCGCCGCCCGCGGGTATTAATAGCCGGCGCCGCCGCGCCCTCGGCCGCCGGGGGCTTGGG
AGCCGCCGATCCCGGAGCCCGAGCCGGGAGAGGGAGCCGCCGCAGCCGCCGGCGCTGTGGAGATATTCTCTAAGCCGCTTTCATCATGGG
AGAAATAGAGCAGAGGCCGACCCCAGGATCACGACTGGGGGCCCCGGAAAATTCGGGGATCAGTACCTTGGAACGTGGACAGAAGCCGCC
CCCAACACCTTCAGGAAAACTCGTGTCCATCAAAATCCAGATGCTGGATGACACCCAGGAGGCATTTGAAGTTCCAGCTTCCGAAGATCT
TCTCAAGGAACACTACGTTGACCTGAAGGACCGTCCATTCTTTGCCGGCCTGGTGAAATACATGCACTCAGGGCCGGTAGTTGCCATGGT
CTGGGAGGGGCTGAATGTGGTGAAGACGGGCCGAGTCATGCTCGGGGAGACCAACCCTGCAGACTCCAAGCCTGGGACCATCCGTGGAGA
CTTCTGCATACAAGTTGGCAGGACCATGGCCAACCTGGAGCGCACCTTCATCGCCATCAAGCCGGACGGCGTGCAGCGCGGCCTGGTGGG
CGAGATCATCAAGCGCTTCGAGCAGAAGGGATTCCGCCTCGTGGCCATGAAGTTCCTCCGGGCCTCTGAAGAACACCTGAAGCAGCACTA
CATTGACCTGAAAGACCGACCATTCTTCCCTGGGCTGGTGAAGTACATGAACTCAGGGCCGGTTGTGGCCATGGTCTGGGAGGGGCTGAA
CGTGGTGAAGACAGGCCGAGTGATGCTTGGGGAGACCAATCCAGCAGATTCAAAGCCAGGCACCATTCGTGGGGACTTCTGCATTCAGGT
TGGCAGGAACATCATTCATGGCAGTGATTCAGTAAAAAGTGCTGAAAAAGAAATCAGCCTATGGTTTAAGCCTGAAGAACTGGTTGACTA
CAAGTCTTGTGCTCATGACTGGGTCTATGAATAAGAGGTGGACACAACAGCAGTCTCCTTCAGCACGGCGTGGTGTGTCCCTGGACACAG

>29379_29379_2_FARP1-NME1-NME2_FARP1_chr13_98865667_ENST00000319562_NME1-NME2_chr17_49237341_ENST00000608447_length(amino acids)=282AA_BP=128
MGEIEQRPTPGSRLGAPENSGISTLERGQKPPPTPSGKLVSIKIQMLDDTQEAFEVPASEDLLKEHYVDLKDRPFFAGLVKYMHSGPVVA
MVWEGLNVVKTGRVMLGETNPADSKPGTIRGDFCIQVGRTMANLERTFIAIKPDGVQRGLVGEIIKRFEQKGFRLVAMKFLRASEEHLKQ
HYIDLKDRPFFPGLVKYMNSGPVVAMVWEGLNVVKTGRVMLGETNPADSKPGTIRGDFCIQVGRNIIHGSDSVKSAEKEISLWFKPEELV

--------------------------------------------------------------
>29379_29379_3_FARP1-NME1-NME2_FARP1_chr13_98865667_ENST00000376581_NME1-NME2_chr17_49237341_ENST00000393198_length(transcript)=1024nt_BP=207nt
CGGCGCTGTGGAGATATTCTCTAAGCCGCTTTCATCATGGGAGAAATAGAGCAGAGGCCGACCCCAGGATCACGACTGGGGGCCCCGGAA
AATTCGGGGATCAGTACCTTGGAACGTGGACAGAAGCCGCCCCCAACACCTTCAGGAAAACTCGTGTCCATCAAAATCCAGATGCTGGAT
GACACCCAGGAGGCATTTGAAGTTCCAGCTTCCGAAGATCTTCTCAAGGAACACTACGTTGACCTGAAGGACCGTCCATTCTTTGCCGGC
CTGGTGAAATACATGCACTCAGGGCCGGTAGTTGCCATGGTCTGGGAGGGGCTGAATGTGGTGAAGACGGGCCGAGTCATGCTCGGGGAG
ACCAACCCTGCAGACTCCAAGCCTGGGACCATCCGTGGAGACTTCTGCATACAAGTTGGCAGGACCATGGCCAACCTGGAGCGCACCTTC
ATCGCCATCAAGCCGGACGGCGTGCAGCGCGGCCTGGTGGGCGAGATCATCAAGCGCTTCGAGCAGAAGGGATTCCGCCTCGTGGCCATG
AAGTTCCTCCGGGCCTCTGAAGAACACCTGAAGCAGCACTACATTGACCTGAAAGACCGACCATTCTTCCCTGGGCTGGTGAAGTACATG
AACTCAGGGCCGGTTGTGGCCATGGTCTGGGAGGGGCTGAACGTGGTGAAGACAGGCCGAGTGATGCTTGGGGAGACCAATCCAGCAGAT
TCAAAGCCAGGCACCATTCGTGGGGACTTCTGCATTCAGGTTGGCAGGAACATCATTCATGGCAGTGATTCAGTAAAAAGTGCTGAAAAA
GAAATCAGCCTATGGTTTAAGCCTGAAGAACTGGTTGACTACAAGTCTTGTGCTCATGACTGGGTCTATGAATAAGAGGTGGACACAACA
GCAGTCTCCTTCAGCACGGCGTGGTGTGTCCCTGGACACAGCTCTTCATTCCATTGACTTAGAGGCAACAGGATTGATCATTCTTTTATA

>29379_29379_3_FARP1-NME1-NME2_FARP1_chr13_98865667_ENST00000376581_NME1-NME2_chr17_49237341_ENST00000393198_length(amino acids)=282AA_BP=128
MGEIEQRPTPGSRLGAPENSGISTLERGQKPPPTPSGKLVSIKIQMLDDTQEAFEVPASEDLLKEHYVDLKDRPFFAGLVKYMHSGPVVA
MVWEGLNVVKTGRVMLGETNPADSKPGTIRGDFCIQVGRTMANLERTFIAIKPDGVQRGLVGEIIKRFEQKGFRLVAMKFLRASEEHLKQ
HYIDLKDRPFFPGLVKYMNSGPVVAMVWEGLNVVKTGRVMLGETNPADSKPGTIRGDFCIQVGRNIIHGSDSVKSAEKEISLWFKPEELV

--------------------------------------------------------------
>29379_29379_4_FARP1-NME1-NME2_FARP1_chr13_98865667_ENST00000376581_NME1-NME2_chr17_49237341_ENST00000608447_length(transcript)=1023nt_BP=207nt
CGGCGCTGTGGAGATATTCTCTAAGCCGCTTTCATCATGGGAGAAATAGAGCAGAGGCCGACCCCAGGATCACGACTGGGGGCCCCGGAA
AATTCGGGGATCAGTACCTTGGAACGTGGACAGAAGCCGCCCCCAACACCTTCAGGAAAACTCGTGTCCATCAAAATCCAGATGCTGGAT
GACACCCAGGAGGCATTTGAAGTTCCAGCTTCCGAAGATCTTCTCAAGGAACACTACGTTGACCTGAAGGACCGTCCATTCTTTGCCGGC
CTGGTGAAATACATGCACTCAGGGCCGGTAGTTGCCATGGTCTGGGAGGGGCTGAATGTGGTGAAGACGGGCCGAGTCATGCTCGGGGAG
ACCAACCCTGCAGACTCCAAGCCTGGGACCATCCGTGGAGACTTCTGCATACAAGTTGGCAGGACCATGGCCAACCTGGAGCGCACCTTC
ATCGCCATCAAGCCGGACGGCGTGCAGCGCGGCCTGGTGGGCGAGATCATCAAGCGCTTCGAGCAGAAGGGATTCCGCCTCGTGGCCATG
AAGTTCCTCCGGGCCTCTGAAGAACACCTGAAGCAGCACTACATTGACCTGAAAGACCGACCATTCTTCCCTGGGCTGGTGAAGTACATG
AACTCAGGGCCGGTTGTGGCCATGGTCTGGGAGGGGCTGAACGTGGTGAAGACAGGCCGAGTGATGCTTGGGGAGACCAATCCAGCAGAT
TCAAAGCCAGGCACCATTCGTGGGGACTTCTGCATTCAGGTTGGCAGGAACATCATTCATGGCAGTGATTCAGTAAAAAGTGCTGAAAAA
GAAATCAGCCTATGGTTTAAGCCTGAAGAACTGGTTGACTACAAGTCTTGTGCTCATGACTGGGTCTATGAATAAGAGGTGGACACAACA
GCAGTCTCCTTCAGCACGGCGTGGTGTGTCCCTGGACACAGCTCTTCATTCCATTGACTTAGAGGCAACAGGATTGATCATTCTTTTATA

>29379_29379_4_FARP1-NME1-NME2_FARP1_chr13_98865667_ENST00000376581_NME1-NME2_chr17_49237341_ENST00000608447_length(amino acids)=282AA_BP=128
MGEIEQRPTPGSRLGAPENSGISTLERGQKPPPTPSGKLVSIKIQMLDDTQEAFEVPASEDLLKEHYVDLKDRPFFAGLVKYMHSGPVVA
MVWEGLNVVKTGRVMLGETNPADSKPGTIRGDFCIQVGRTMANLERTFIAIKPDGVQRGLVGEIIKRFEQKGFRLVAMKFLRASEEHLKQ
HYIDLKDRPFFPGLVKYMNSGPVVAMVWEGLNVVKTGRVMLGETNPADSKPGTIRGDFCIQVGRNIIHGSDSVKSAEKEISLWFKPEELV

--------------------------------------------------------------
>29379_29379_5_FARP1-NME1-NME2_FARP1_chr13_98865667_ENST00000376586_NME1-NME2_chr17_49237341_ENST00000393198_length(transcript)=1324nt_BP=507nt
GCGGCCGCTGCCCGCTTTGCGCCGCTCCTCCCTGCGCGAGTAGCGCTGGCCCCGGCGTCGAGGCGGCCATGGCGACCCGGAGCCCGCTCC
CCACCCACCCCGCCTGCTCCGCCCTCCCCTCCGCCCCGCGCCACCTTTGATGGCTCGGACCTCAGCCGGCCACCGCCAGCCCTGCTCGCG
CGCCCGCGCCGCCGCCGCCCGCGGGTATTAATAGCCGGCGCCGCCGCGCCCTCGGCCGCCGGGGGCTTGGGAGCCGCCGATCCCGGAGCC
CGAGCCGGGAGAGGGAGCCGCCGCAGCCGCCGGCGCTGTGGAGATATTCTCTAAGCCGCTTTCATCATGGGAGAAATAGAGCAGAGGCCG
ACCCCAGGATCACGACTGGGGGCCCCGGAAAATTCGGGGATCAGTACCTTGGAACGTGGACAGAAGCCGCCCCCAACACCTTCAGGAAAA
CTCGTGTCCATCAAAATCCAGATGCTGGATGACACCCAGGAGGCATTTGAAGTTCCAGCTTCCGAAGATCTTCTCAAGGAACACTACGTT
GACCTGAAGGACCGTCCATTCTTTGCCGGCCTGGTGAAATACATGCACTCAGGGCCGGTAGTTGCCATGGTCTGGGAGGGGCTGAATGTG
GTGAAGACGGGCCGAGTCATGCTCGGGGAGACCAACCCTGCAGACTCCAAGCCTGGGACCATCCGTGGAGACTTCTGCATACAAGTTGGC
AGGACCATGGCCAACCTGGAGCGCACCTTCATCGCCATCAAGCCGGACGGCGTGCAGCGCGGCCTGGTGGGCGAGATCATCAAGCGCTTC
GAGCAGAAGGGATTCCGCCTCGTGGCCATGAAGTTCCTCCGGGCCTCTGAAGAACACCTGAAGCAGCACTACATTGACCTGAAAGACCGA
CCATTCTTCCCTGGGCTGGTGAAGTACATGAACTCAGGGCCGGTTGTGGCCATGGTCTGGGAGGGGCTGAACGTGGTGAAGACAGGCCGA
GTGATGCTTGGGGAGACCAATCCAGCAGATTCAAAGCCAGGCACCATTCGTGGGGACTTCTGCATTCAGGTTGGCAGGAACATCATTCAT
GGCAGTGATTCAGTAAAAAGTGCTGAAAAAGAAATCAGCCTATGGTTTAAGCCTGAAGAACTGGTTGACTACAAGTCTTGTGCTCATGAC
TGGGTCTATGAATAAGAGGTGGACACAACAGCAGTCTCCTTCAGCACGGCGTGGTGTGTCCCTGGACACAGCTCTTCATTCCATTGACTT

>29379_29379_5_FARP1-NME1-NME2_FARP1_chr13_98865667_ENST00000376586_NME1-NME2_chr17_49237341_ENST00000393198_length(amino acids)=282AA_BP=128
MGEIEQRPTPGSRLGAPENSGISTLERGQKPPPTPSGKLVSIKIQMLDDTQEAFEVPASEDLLKEHYVDLKDRPFFAGLVKYMHSGPVVA
MVWEGLNVVKTGRVMLGETNPADSKPGTIRGDFCIQVGRTMANLERTFIAIKPDGVQRGLVGEIIKRFEQKGFRLVAMKFLRASEEHLKQ
HYIDLKDRPFFPGLVKYMNSGPVVAMVWEGLNVVKTGRVMLGETNPADSKPGTIRGDFCIQVGRNIIHGSDSVKSAEKEISLWFKPEELV

--------------------------------------------------------------
>29379_29379_6_FARP1-NME1-NME2_FARP1_chr13_98865667_ENST00000376586_NME1-NME2_chr17_49237341_ENST00000608447_length(transcript)=1323nt_BP=507nt
GCGGCCGCTGCCCGCTTTGCGCCGCTCCTCCCTGCGCGAGTAGCGCTGGCCCCGGCGTCGAGGCGGCCATGGCGACCCGGAGCCCGCTCC
CCACCCACCCCGCCTGCTCCGCCCTCCCCTCCGCCCCGCGCCACCTTTGATGGCTCGGACCTCAGCCGGCCACCGCCAGCCCTGCTCGCG
CGCCCGCGCCGCCGCCGCCCGCGGGTATTAATAGCCGGCGCCGCCGCGCCCTCGGCCGCCGGGGGCTTGGGAGCCGCCGATCCCGGAGCC
CGAGCCGGGAGAGGGAGCCGCCGCAGCCGCCGGCGCTGTGGAGATATTCTCTAAGCCGCTTTCATCATGGGAGAAATAGAGCAGAGGCCG
ACCCCAGGATCACGACTGGGGGCCCCGGAAAATTCGGGGATCAGTACCTTGGAACGTGGACAGAAGCCGCCCCCAACACCTTCAGGAAAA
CTCGTGTCCATCAAAATCCAGATGCTGGATGACACCCAGGAGGCATTTGAAGTTCCAGCTTCCGAAGATCTTCTCAAGGAACACTACGTT
GACCTGAAGGACCGTCCATTCTTTGCCGGCCTGGTGAAATACATGCACTCAGGGCCGGTAGTTGCCATGGTCTGGGAGGGGCTGAATGTG
GTGAAGACGGGCCGAGTCATGCTCGGGGAGACCAACCCTGCAGACTCCAAGCCTGGGACCATCCGTGGAGACTTCTGCATACAAGTTGGC
AGGACCATGGCCAACCTGGAGCGCACCTTCATCGCCATCAAGCCGGACGGCGTGCAGCGCGGCCTGGTGGGCGAGATCATCAAGCGCTTC
GAGCAGAAGGGATTCCGCCTCGTGGCCATGAAGTTCCTCCGGGCCTCTGAAGAACACCTGAAGCAGCACTACATTGACCTGAAAGACCGA
CCATTCTTCCCTGGGCTGGTGAAGTACATGAACTCAGGGCCGGTTGTGGCCATGGTCTGGGAGGGGCTGAACGTGGTGAAGACAGGCCGA
GTGATGCTTGGGGAGACCAATCCAGCAGATTCAAAGCCAGGCACCATTCGTGGGGACTTCTGCATTCAGGTTGGCAGGAACATCATTCAT
GGCAGTGATTCAGTAAAAAGTGCTGAAAAAGAAATCAGCCTATGGTTTAAGCCTGAAGAACTGGTTGACTACAAGTCTTGTGCTCATGAC
TGGGTCTATGAATAAGAGGTGGACACAACAGCAGTCTCCTTCAGCACGGCGTGGTGTGTCCCTGGACACAGCTCTTCATTCCATTGACTT

>29379_29379_6_FARP1-NME1-NME2_FARP1_chr13_98865667_ENST00000376586_NME1-NME2_chr17_49237341_ENST00000608447_length(amino acids)=282AA_BP=128
MGEIEQRPTPGSRLGAPENSGISTLERGQKPPPTPSGKLVSIKIQMLDDTQEAFEVPASEDLLKEHYVDLKDRPFFAGLVKYMHSGPVVA
MVWEGLNVVKTGRVMLGETNPADSKPGTIRGDFCIQVGRTMANLERTFIAIKPDGVQRGLVGEIIKRFEQKGFRLVAMKFLRASEEHLKQ
HYIDLKDRPFFPGLVKYMNSGPVVAMVWEGLNVVKTGRVMLGETNPADSKPGTIRGDFCIQVGRNIIHGSDSVKSAEKEISLWFKPEELV

--------------------------------------------------------------
>29379_29379_7_FARP1-NME1-NME2_FARP1_chr13_98865667_ENST00000595437_NME1-NME2_chr17_49237341_ENST00000393198_length(transcript)=1227nt_BP=410nt
AAGTCCCGCGCAGCCCGGGGTGGTGCCGGAAGCCCGTGCCTGTGGCTCCGGGGGAGGGGAGGGCTCGGTGGGTCCCTGAAGACTGTCCTC
CCCGCGCGACGTCGCAGGCGAAGCAGCCCCAGGCAGGACCTCAAAAAGCGACCTGCAGAGTCCGAGCCCCTGACCGCCCGCCTGCCGCTC
CCGGCTTCGCCGTGCACACGTCTCCCGCTCTCCCCGATATTCTCTAAGCCGCTTTCATCATGGGAGAAATAGAGCAGAGGCCGACCCCAG
GATCACGACTGGGGGCCCCGGAAAATTCGGGGATCAGTACCTTGGAACGTGGACAGAAGCCGCCCCCAACACCTTCAGGAAAACTCGTGT
CCATCAAAATCCAGATGCTGGATGACACCCAGGAGGCATTTGAAGTTCCAGCTTCCGAAGATCTTCTCAAGGAACACTACGTTGACCTGA
AGGACCGTCCATTCTTTGCCGGCCTGGTGAAATACATGCACTCAGGGCCGGTAGTTGCCATGGTCTGGGAGGGGCTGAATGTGGTGAAGA
CGGGCCGAGTCATGCTCGGGGAGACCAACCCTGCAGACTCCAAGCCTGGGACCATCCGTGGAGACTTCTGCATACAAGTTGGCAGGACCA
TGGCCAACCTGGAGCGCACCTTCATCGCCATCAAGCCGGACGGCGTGCAGCGCGGCCTGGTGGGCGAGATCATCAAGCGCTTCGAGCAGA
AGGGATTCCGCCTCGTGGCCATGAAGTTCCTCCGGGCCTCTGAAGAACACCTGAAGCAGCACTACATTGACCTGAAAGACCGACCATTCT
TCCCTGGGCTGGTGAAGTACATGAACTCAGGGCCGGTTGTGGCCATGGTCTGGGAGGGGCTGAACGTGGTGAAGACAGGCCGAGTGATGC
TTGGGGAGACCAATCCAGCAGATTCAAAGCCAGGCACCATTCGTGGGGACTTCTGCATTCAGGTTGGCAGGAACATCATTCATGGCAGTG
ATTCAGTAAAAAGTGCTGAAAAAGAAATCAGCCTATGGTTTAAGCCTGAAGAACTGGTTGACTACAAGTCTTGTGCTCATGACTGGGTCT
ATGAATAAGAGGTGGACACAACAGCAGTCTCCTTCAGCACGGCGTGGTGTGTCCCTGGACACAGCTCTTCATTCCATTGACTTAGAGGCA

>29379_29379_7_FARP1-NME1-NME2_FARP1_chr13_98865667_ENST00000595437_NME1-NME2_chr17_49237341_ENST00000393198_length(amino acids)=282AA_BP=128
MGEIEQRPTPGSRLGAPENSGISTLERGQKPPPTPSGKLVSIKIQMLDDTQEAFEVPASEDLLKEHYVDLKDRPFFAGLVKYMHSGPVVA
MVWEGLNVVKTGRVMLGETNPADSKPGTIRGDFCIQVGRTMANLERTFIAIKPDGVQRGLVGEIIKRFEQKGFRLVAMKFLRASEEHLKQ
HYIDLKDRPFFPGLVKYMNSGPVVAMVWEGLNVVKTGRVMLGETNPADSKPGTIRGDFCIQVGRNIIHGSDSVKSAEKEISLWFKPEELV

--------------------------------------------------------------
>29379_29379_8_FARP1-NME1-NME2_FARP1_chr13_98865667_ENST00000595437_NME1-NME2_chr17_49237341_ENST00000608447_length(transcript)=1226nt_BP=410nt
AAGTCCCGCGCAGCCCGGGGTGGTGCCGGAAGCCCGTGCCTGTGGCTCCGGGGGAGGGGAGGGCTCGGTGGGTCCCTGAAGACTGTCCTC
CCCGCGCGACGTCGCAGGCGAAGCAGCCCCAGGCAGGACCTCAAAAAGCGACCTGCAGAGTCCGAGCCCCTGACCGCCCGCCTGCCGCTC
CCGGCTTCGCCGTGCACACGTCTCCCGCTCTCCCCGATATTCTCTAAGCCGCTTTCATCATGGGAGAAATAGAGCAGAGGCCGACCCCAG
GATCACGACTGGGGGCCCCGGAAAATTCGGGGATCAGTACCTTGGAACGTGGACAGAAGCCGCCCCCAACACCTTCAGGAAAACTCGTGT
CCATCAAAATCCAGATGCTGGATGACACCCAGGAGGCATTTGAAGTTCCAGCTTCCGAAGATCTTCTCAAGGAACACTACGTTGACCTGA
AGGACCGTCCATTCTTTGCCGGCCTGGTGAAATACATGCACTCAGGGCCGGTAGTTGCCATGGTCTGGGAGGGGCTGAATGTGGTGAAGA
CGGGCCGAGTCATGCTCGGGGAGACCAACCCTGCAGACTCCAAGCCTGGGACCATCCGTGGAGACTTCTGCATACAAGTTGGCAGGACCA
TGGCCAACCTGGAGCGCACCTTCATCGCCATCAAGCCGGACGGCGTGCAGCGCGGCCTGGTGGGCGAGATCATCAAGCGCTTCGAGCAGA
AGGGATTCCGCCTCGTGGCCATGAAGTTCCTCCGGGCCTCTGAAGAACACCTGAAGCAGCACTACATTGACCTGAAAGACCGACCATTCT
TCCCTGGGCTGGTGAAGTACATGAACTCAGGGCCGGTTGTGGCCATGGTCTGGGAGGGGCTGAACGTGGTGAAGACAGGCCGAGTGATGC
TTGGGGAGACCAATCCAGCAGATTCAAAGCCAGGCACCATTCGTGGGGACTTCTGCATTCAGGTTGGCAGGAACATCATTCATGGCAGTG
ATTCAGTAAAAAGTGCTGAAAAAGAAATCAGCCTATGGTTTAAGCCTGAAGAACTGGTTGACTACAAGTCTTGTGCTCATGACTGGGTCT
ATGAATAAGAGGTGGACACAACAGCAGTCTCCTTCAGCACGGCGTGGTGTGTCCCTGGACACAGCTCTTCATTCCATTGACTTAGAGGCA

>29379_29379_8_FARP1-NME1-NME2_FARP1_chr13_98865667_ENST00000595437_NME1-NME2_chr17_49237341_ENST00000608447_length(amino acids)=282AA_BP=128
MGEIEQRPTPGSRLGAPENSGISTLERGQKPPPTPSGKLVSIKIQMLDDTQEAFEVPASEDLLKEHYVDLKDRPFFAGLVKYMHSGPVVA
MVWEGLNVVKTGRVMLGETNPADSKPGTIRGDFCIQVGRTMANLERTFIAIKPDGVQRGLVGEIIKRFEQKGFRLVAMKFLRASEEHLKQ
HYIDLKDRPFFPGLVKYMNSGPVVAMVWEGLNVVKTGRVMLGETNPADSKPGTIRGDFCIQVGRNIIHGSDSVKSAEKEISLWFKPEELV

--------------------------------------------------------------

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Fusion Gene PPI Analysis for FARP1-NME1-NME2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
TgeneNME1-NME2chr13:98865667chr17:49237341ENST00000393198181_6642.0268.0AKAP13


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for FARP1-NME1-NME2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for FARP1-NME1-NME2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneFARP1C0013146Drug abuse1CTD_human
HgeneFARP1C0013170Drug habituation1CTD_human
HgeneFARP1C0013222Drug Use Disorders1CTD_human
HgeneFARP1C0029231Organic Mental Disorders, Substance-Induced1CTD_human
HgeneFARP1C0038580Substance Dependence1CTD_human
HgeneFARP1C0038586Substance Use Disorders1CTD_human
HgeneFARP1C0236969Substance-Related Disorders1CTD_human
HgeneFARP1C0740858Substance abuse problem1CTD_human
HgeneFARP1C1510472Drug Dependence1CTD_human
HgeneFARP1C4316881Prescription Drug Abuse1CTD_human