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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:DHRS2-GAPDH (FusionGDB2 ID:HG10202TG2597)

Fusion Gene Summary for DHRS2-GAPDH

check button Fusion gene summary
Fusion gene informationFusion gene name: DHRS2-GAPDH
Fusion gene ID: hg10202tg2597
HgeneTgene
Gene symbol

DHRS2

GAPDH

Gene ID

10202

2597

Gene namedehydrogenase/reductase 2glyceraldehyde-3-phosphate dehydrogenase
SynonymsHEP27|SDR25C1G3PD|GAPD|HEL-S-162eP
Cytomap('DHRS2')('GAPDH')

14q11.2

12p13.31

Type of geneprotein-codingprotein-coding
Descriptiondehydrogenase/reductase SDR family member 2, mitochondrialdehydrogenase/reductase (SDR family) member 2dehydrogenase/reductase member 2dicarbonyl reductase HEP27protein Dshort chain dehydrogenase/reductase family 25C member 1short-chain alcohol dehyglyceraldehyde-3-phosphate dehydrogenaseOCAS, p38 componentOct1 coactivator in S phase, 38 Kd componentaging-associated gene 9 proteinepididymis secretory sperm binding protein Li 162ePpeptidyl-cysteine S-nitrosylase GAPDH
Modification date2020032920200327
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000250383, ENST00000344777, 
ENST00000553896, 
Fusion gene scores* DoF score4 X 4 X 2=3227 X 29 X 8=6264
# samples 531
** MAII scorelog2(5/32*10)=0.643856189774725
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(31/6264*10)=-4.3367440920168
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: DHRS2 [Title/Abstract] AND GAPDH [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointDHRS2(24105981)-GAPDH(6645660), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneDHRS2

GO:0009636

response to toxic substance

16685466

HgeneDHRS2

GO:0034599

cellular response to oxidative stress

19443906

HgeneDHRS2

GO:0055114

oxidation-reduction process

16685466

TgeneGAPDH

GO:0010951

negative regulation of endopeptidase activity

22832495

TgeneGAPDH

GO:0017148

negative regulation of translation

23071094

TgeneGAPDH

GO:0031640

killing of cells of other organism

22832495

TgeneGAPDH

GO:0050715

positive regulation of cytokine secretion

22832495

TgeneGAPDH

GO:0050832

defense response to fungus

22832495

TgeneGAPDH

GO:0051873

killing by host of symbiont cells

22832495

TgeneGAPDH

GO:0052501

positive regulation by organism of apoptotic process in other organism involved in symbiotic interaction

22832495

TgeneGAPDH

GO:0061844

antimicrobial humoral immune response mediated by antimicrobial peptide

22832495

TgeneGAPDH

GO:0071346

cellular response to interferon-gamma

15479637



check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BLCATCGA-GV-A3QI-01ADHRS2chr14

24105981

+GAPDHchr12

6645660

+


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Fusion Gene ORF analysis for DHRS2-GAPDH

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000250383ENST00000229239DHRS2chr14

24105981

+GAPDHchr12

6645660

+
5UTR-3CDSENST00000344777ENST00000229239DHRS2chr14

24105981

+GAPDHchr12

6645660

+
5UTR-5UTRENST00000250383ENST00000396856DHRS2chr14

24105981

+GAPDHchr12

6645660

+
5UTR-5UTRENST00000250383ENST00000396858DHRS2chr14

24105981

+GAPDHchr12

6645660

+
5UTR-5UTRENST00000250383ENST00000396859DHRS2chr14

24105981

+GAPDHchr12

6645660

+
5UTR-5UTRENST00000250383ENST00000396861DHRS2chr14

24105981

+GAPDHchr12

6645660

+
5UTR-5UTRENST00000344777ENST00000396856DHRS2chr14

24105981

+GAPDHchr12

6645660

+
5UTR-5UTRENST00000344777ENST00000396858DHRS2chr14

24105981

+GAPDHchr12

6645660

+
5UTR-5UTRENST00000344777ENST00000396859DHRS2chr14

24105981

+GAPDHchr12

6645660

+
5UTR-5UTRENST00000344777ENST00000396861DHRS2chr14

24105981

+GAPDHchr12

6645660

+
intron-3CDSENST00000553896ENST00000229239DHRS2chr14

24105981

+GAPDHchr12

6645660

+
intron-5UTRENST00000553896ENST00000396856DHRS2chr14

24105981

+GAPDHchr12

6645660

+
intron-5UTRENST00000553896ENST00000396858DHRS2chr14

24105981

+GAPDHchr12

6645660

+
intron-5UTRENST00000553896ENST00000396859DHRS2chr14

24105981

+GAPDHchr12

6645660

+
intron-5UTRENST00000553896ENST00000396861DHRS2chr14

24105981

+GAPDHchr12

6645660

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for DHRS2-GAPDH


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
DHRS2chr1424105981+GAPDHchr126645659+0.0240106730.97598934
DHRS2chr1424105981+GAPDHchr126645659+0.0240106730.97598934


check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for DHRS2-GAPDH


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:24105981/:6645660)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for DHRS2-GAPDH


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for DHRS2-GAPDH


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for DHRS2-GAPDH


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for DHRS2-GAPDH


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneC2239176Liver carcinoma2CTD_human
TgeneC0001787Osteoporosis, Age-Related1CTD_human
TgeneC0001973Alcoholic Intoxication, Chronic1PSYGENET
TgeneC0003129Anoxemia1CTD_human
TgeneC0003130Anoxia1CTD_human
TgeneC0007137Squamous cell carcinoma1CTD_human
TgeneC0009402Colorectal Carcinoma1CTD_human
TgeneC0009404Colorectal Neoplasms1CTD_human
TgeneC0014859Esophageal Neoplasms1CTD_human
TgeneC0026640Mouth Neoplasms1CTD_human
TgeneC0027540Necrosis1CTD_human
TgeneC0029408Degenerative polyarthritis1CTD_human
TgeneC0029456Osteoporosis1CTD_human
TgeneC0029459Osteoporosis, Senile1CTD_human
TgeneC0086743Osteoarthrosis Deformans1CTD_human
TgeneC0152013Adenocarcinoma of lung (disorder)1CTD_human
TgeneC0153381Malignant neoplasm of mouth1CTD_human
TgeneC0242184Hypoxia1CTD_human
TgeneC0546837Malignant neoplasm of esophagus1CTD_human
TgeneC0700292Hypoxemia1CTD_human
TgeneC0751406Post-Traumatic Osteoporosis1CTD_human
TgeneC0948089Acute Coronary Syndrome1CTD_human