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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:DHRS2-IL25 (FusionGDB2 ID:HG10202TG64806)

Fusion Gene Summary for DHRS2-IL25

check button Fusion gene summary
Fusion gene informationFusion gene name: DHRS2-IL25
Fusion gene ID: hg10202tg64806
HgeneTgene
Gene symbol

DHRS2

IL25

Gene ID

10202

64806

Gene namedehydrogenase/reductase 2interleukin 25
SynonymsHEP27|SDR25C1IL17E
Cytomap('DHRS2')('IL25')

14q11.2

14q11.2

Type of geneprotein-codingprotein-coding
Descriptiondehydrogenase/reductase SDR family member 2, mitochondrialdehydrogenase/reductase (SDR family) member 2dehydrogenase/reductase member 2dicarbonyl reductase HEP27protein Dshort chain dehydrogenase/reductase family 25C member 1short-chain alcohol dehyinterleukin-25interleukin-17E
Modification date2020032920200322
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000553896, ENST00000250383, 
ENST00000344777, 
Fusion gene scores* DoF score4 X 4 X 2=321 X 2 X 1=2
# samples 52
** MAII scorelog2(5/32*10)=0.643856189774725
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(2/2*10)=3.32192809488736
Context

PubMed: DHRS2 [Title/Abstract] AND IL25 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointDHRS2(24109104)-IL25(23844834), # samples:3
Anticipated loss of major functional domain due to fusion event.DHRS2-IL25 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneDHRS2

GO:0009636

response to toxic substance

16685466

HgeneDHRS2

GO:0034599

cellular response to oxidative stress

19443906

HgeneDHRS2

GO:0055114

oxidation-reduction process

16685466



check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BLCATCGA-E7-A85H-01ADHRS2chr14

24109104

-IL25chr14

23844834

+
ChimerDB4BLCATCGA-E7-A85H-01ADHRS2chr14

24109104

+IL25chr14

23844834

+
ChimerDB4BLCATCGA-E7-A85HDHRS2chr14

24108565

+IL25chr14

23844833

+
ChimerDB4BLCATCGA-E7-A85HDHRS2chr14

24109104

+IL25chr14

23844833

+


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Fusion Gene ORF analysis for DHRS2-IL25

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000553896ENST00000329715DHRS2chr14

24109104

+IL25chr14

23844834

+
3UTR-3CDSENST00000553896ENST00000329715DHRS2chr14

24108565

+IL25chr14

23844833

+
3UTR-3CDSENST00000553896ENST00000329715DHRS2chr14

24109104

+IL25chr14

23844833

+
3UTR-3CDSENST00000553896ENST00000397242DHRS2chr14

24109104

+IL25chr14

23844834

+
3UTR-3CDSENST00000553896ENST00000397242DHRS2chr14

24108565

+IL25chr14

23844833

+
3UTR-3CDSENST00000553896ENST00000397242DHRS2chr14

24109104

+IL25chr14

23844833

+
Frame-shiftENST00000250383ENST00000329715DHRS2chr14

24109104

+IL25chr14

23844834

+
Frame-shiftENST00000250383ENST00000329715DHRS2chr14

24108565

+IL25chr14

23844833

+
Frame-shiftENST00000250383ENST00000329715DHRS2chr14

24109104

+IL25chr14

23844833

+
Frame-shiftENST00000250383ENST00000397242DHRS2chr14

24109104

+IL25chr14

23844834

+
Frame-shiftENST00000250383ENST00000397242DHRS2chr14

24108565

+IL25chr14

23844833

+
Frame-shiftENST00000250383ENST00000397242DHRS2chr14

24109104

+IL25chr14

23844833

+
Frame-shiftENST00000344777ENST00000329715DHRS2chr14

24109104

+IL25chr14

23844834

+
Frame-shiftENST00000344777ENST00000329715DHRS2chr14

24108565

+IL25chr14

23844833

+
Frame-shiftENST00000344777ENST00000329715DHRS2chr14

24109104

+IL25chr14

23844833

+
Frame-shiftENST00000344777ENST00000397242DHRS2chr14

24109104

+IL25chr14

23844834

+
Frame-shiftENST00000344777ENST00000397242DHRS2chr14

24108565

+IL25chr14

23844833

+
Frame-shiftENST00000344777ENST00000397242DHRS2chr14

24109104

+IL25chr14

23844833

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for DHRS2-IL25


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
DHRS2chr1424109104+IL25chr1423844833+1.94E-060.9999981
DHRS2chr1424109104+IL25chr1423844833+1.94E-060.9999981
DHRS2chr1424108565+IL25chr1423844833+1.71E-060.99999833
DHRS2chr1424109104+IL25chr1423844833+1.94E-060.9999981
DHRS2chr1424109104+IL25chr1423844833+1.94E-060.9999981
DHRS2chr1424108565+IL25chr1423844833+1.71E-060.99999833


check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for DHRS2-IL25


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:24109104/:23844834)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for DHRS2-IL25


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for DHRS2-IL25


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for DHRS2-IL25


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for DHRS2-IL25


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource