|
||||||
|
 | Fusion Gene Summary |
| Fusion Gene ORF analysis |
| Fusion Genomic Features |
| Fusion Protein Features |
| Fusion Gene Sequence |
| Fusion Gene PPI analysis |
| Related Drugs |
| Related Diseases |
Fusion gene:AP3S2-GAREM (FusionGDB2 ID:HG10239TG64762) |
Fusion Gene Summary for AP3S2-GAREM |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: AP3S2-GAREM | Fusion gene ID: hg10239tg64762 | Hgene | Tgene | Gene symbol | AP3S2 | GAREM | Gene ID | 10239 | 64762 |
| Gene name | adaptor related protein complex 3 subunit sigma 2 | GRB2 associated regulator of MAPK1 subtype 1 | |
| Synonyms | AP3S3|sigma3b | C18orf11|FAM59A|GAREM|Gm944 | |
| Cytomap | ('AP3S2')('GAREM') 15q26.1 | 18q12.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | AP-3 complex subunit sigma-2AP-3 complex subunit sigma-3Badapter-related protein complex 3 subunit sigma-2adaptor complex sigma3Badaptor related protein complex 3 sigma 2 subunitclathrin-associated/assembly/adaptor protein, small 4, 22-kDsigma-3B-ad | GRB2-associated and regulator of MAPK protein 1GRB2 associated regulator of MAPK1 1GRB2 associated, regulator of MAPK1GRB2-associated and regulator of MAPK1Grb2-associated and regulator of Erk/MAPKfamily with sequence similarity 59, member Aprotein | |
| Modification date | 20200313 | 20200327 | |
| UniProtAcc | P59780 | . | |
| Ensembl transtripts involved in fusion gene | ENST00000336418, ENST00000558011, ENST00000560940, ENST00000560771, | ||
| Fusion gene scores | * DoF score | 3 X 1 X 2=6 | 4 X 3 X 3=36 |
| # samples | 3 | 3 | |
| ** MAII score | log2(3/6*10)=2.32192809488736 | log2(3/36*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: AP3S2 [Title/Abstract] AND GAREM [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint | AP3S2(90414707)-GAREM(29868166), # samples:1 | ||
| Anticipated loss of major functional domain due to fusion event. | AP3S2-GAREM seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. AP3S2-GAREM seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. AP3S2-GAREM seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. AP3S2-GAREM seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | GAREM | GO:0007173 | epidermal growth factor receptor signaling pathway | 19509291 |
| Tgene | GAREM | GO:0008284 | positive regulation of cell proliferation | 19509291 |
| Tgene | GAREM | GO:0071364 | cellular response to epidermal growth factor stimulus | 19509291 |
| Fusion gene breakpoints across AP3S2 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
 |
| Fusion gene breakpoints across GAREM (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
 |
| Fusion gene information * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | STAD | TCGA-CD-A4MH-01A | AP3S2 | chr15 | 90414707 | - | GAREM | chr18 | 29868166 | - |
Top |
Fusion Gene ORF analysis for AP3S2-GAREM |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-5UTR | ENST00000336418 | ENST00000578619 | AP3S2 | chr15 | 90414707 | - | GAREM | chr18 | 29868166 | - |
| 5CDS-5UTR | ENST00000558011 | ENST00000578619 | AP3S2 | chr15 | 90414707 | - | GAREM | chr18 | 29868166 | - |
| 5CDS-5UTR | ENST00000560940 | ENST00000578619 | AP3S2 | chr15 | 90414707 | - | GAREM | chr18 | 29868166 | - |
| In-frame | ENST00000336418 | ENST00000269209 | AP3S2 | chr15 | 90414707 | - | GAREM | chr18 | 29868166 | - |
| In-frame | ENST00000336418 | ENST00000399218 | AP3S2 | chr15 | 90414707 | - | GAREM | chr18 | 29868166 | - |
| In-frame | ENST00000558011 | ENST00000269209 | AP3S2 | chr15 | 90414707 | - | GAREM | chr18 | 29868166 | - |
| In-frame | ENST00000558011 | ENST00000399218 | AP3S2 | chr15 | 90414707 | - | GAREM | chr18 | 29868166 | - |
| In-frame | ENST00000560940 | ENST00000269209 | AP3S2 | chr15 | 90414707 | - | GAREM | chr18 | 29868166 | - |
| In-frame | ENST00000560940 | ENST00000399218 | AP3S2 | chr15 | 90414707 | - | GAREM | chr18 | 29868166 | - |
| intron-3CDS | ENST00000560771 | ENST00000269209 | AP3S2 | chr15 | 90414707 | - | GAREM | chr18 | 29868166 | - |
| intron-3CDS | ENST00000560771 | ENST00000399218 | AP3S2 | chr15 | 90414707 | - | GAREM | chr18 | 29868166 | - |
| intron-5UTR | ENST00000560771 | ENST00000578619 | AP3S2 | chr15 | 90414707 | - | GAREM | chr18 | 29868166 | - |
| ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| ENST00000336418 | AP3S2 | chr15 | 90414707 | - | ENST00000399218 | GAREM | chr18 | 29868166 | - | 7322 | 738 | 369 | 2972 | 867 |
| ENST00000336418 | AP3S2 | chr15 | 90414707 | - | ENST00000269209 | GAREM | chr18 | 29868166 | - | 3347 | 738 | 369 | 2975 | 868 |
| ENST00000558011 | AP3S2 | chr15 | 90414707 | - | ENST00000399218 | GAREM | chr18 | 29868166 | - | 7010 | 426 | 21 | 2660 | 879 |
| ENST00000558011 | AP3S2 | chr15 | 90414707 | - | ENST00000269209 | GAREM | chr18 | 29868166 | - | 3035 | 426 | 21 | 2663 | 880 |
| ENST00000560940 | AP3S2 | chr15 | 90414707 | - | ENST00000399218 | GAREM | chr18 | 29868166 | - | 6961 | 377 | 8 | 2611 | 867 |
| ENST00000560940 | AP3S2 | chr15 | 90414707 | - | ENST00000269209 | GAREM | chr18 | 29868166 | - | 2986 | 377 | 8 | 2614 | 868 |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
| ENST00000336418 | ENST00000399218 | AP3S2 | chr15 | 90414707 | - | GAREM | chr18 | 29868166 | - | 0.000345146 | 0.9996549 |
| ENST00000336418 | ENST00000269209 | AP3S2 | chr15 | 90414707 | - | GAREM | chr18 | 29868166 | - | 0.00326142 | 0.9967386 |
| ENST00000558011 | ENST00000399218 | AP3S2 | chr15 | 90414707 | - | GAREM | chr18 | 29868166 | - | 0.00029523 | 0.9997048 |
| ENST00000558011 | ENST00000269209 | AP3S2 | chr15 | 90414707 | - | GAREM | chr18 | 29868166 | - | 0.002004565 | 0.9979955 |
| ENST00000560940 | ENST00000399218 | AP3S2 | chr15 | 90414707 | - | GAREM | chr18 | 29868166 | - | 0.000311549 | 0.9996885 |
| ENST00000560940 | ENST00000269209 | AP3S2 | chr15 | 90414707 | - | GAREM | chr18 | 29868166 | - | 0.002589451 | 0.9974106 |
Top |
Fusion Genomic Features for AP3S2-GAREM |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
 |
Top |
Fusion Protein Features for AP3S2-GAREM |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr15:90414707/chr18:29868166) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| AP3S2 | . |
| FUNCTION: Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. | FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | GAREM | chr15:90414707 | chr18:29868166 | ENST00000269209 | 2 | 6 | 512_566 | 131 | 877.0 | Compositional bias | Note=Pro-rich | |
| Tgene | GAREM | chr15:90414707 | chr18:29868166 | ENST00000399218 | 2 | 6 | 512_566 | 131 | 876.0 | Compositional bias | Note=Pro-rich | |
| Tgene | GAREM | chr15:90414707 | chr18:29868166 | ENST00000269209 | 2 | 6 | 811_876 | 131 | 877.0 | Domain | Note=SAM | |
| Tgene | GAREM | chr15:90414707 | chr18:29868166 | ENST00000399218 | 2 | 6 | 811_876 | 131 | 876.0 | Domain | Note=SAM |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | GAREM | chr15:90414707 | chr18:29868166 | ENST00000269209 | 2 | 6 | 12_320 | 131 | 877.0 | Region | Note=CABIT | |
| Tgene | GAREM | chr15:90414707 | chr18:29868166 | ENST00000399218 | 2 | 6 | 12_320 | 131 | 876.0 | Region | Note=CABIT |
Top |
Fusion Gene Sequence for AP3S2-GAREM |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >5302_5302_1_AP3S2-GAREM_AP3S2_chr15_90414707_ENST00000336418_GAREM_chr18_29868166_ENST00000269209_length(transcript)=3347nt_BP=738nt ACGTTCTGCGAGCGCTAAGGGGATGGCGGGAGTGCATGATTTGGAGCGGGCGGTGAGAAAAGCAAGCTCCCGCCGCCTCTCCGTTTTGGC AACCCGGCTGACGGTCGTTTCGGCTTCTGGGGCCAGCCGTCGGTCTGGGCGAGGGACATAGATCCGGATTCGCATCCTGACTGGCCAACC AACGCTGGCCGAGGTGACCACTCTCCTCGGCATCCGCACCTGCCCTCCAAGGCGTCAGAGAGGCCGGACCCTTGGGTGCTAGGGCTCGTG AGCGCCGGGGCCAAGTTTCCGAGTGCCGCTCTCAGCAGCGCACCAACCGGAAGTGATCGTGTTGTGGCGGAAGGAGGAGCTTTCTGGGAG TAGCCGGTGCTGAGAGAACCGTGGCTGGCAAAGATGATTCAGGCGATTCTGGTTTTCAACAACCATGGGAAGCCACGGCTAGTCCGCTTC TACCAGCGTTTCCCAGAAGAAATTCAACAGCAGATTGTTCGAGAGACTTTCCATCTAGTCCTCAAGCGGGATGACAACATCTGTAACTTC TTGGAGGGTGGAAGTTTGATTGGTGGCTCTGACTACAAACTGATCTACCGGCACTATGCTACCCTCTACTTTGTATTTTGTGTGGATTCC TCAGAGAGTGAACTTGGAATCTTGGACCTCATCCAGGTTTTTGTGGAAACTCTGGATAAGTGTTTCGAAAATGTGTGTGAATTGGATTTG ATCTTCCATATGGATAAGGTTGCTTCAGGTGAATGCAATGAAGACACTGAAGTTTACAACATCACCCTGTGTACTGGGGATGAACTCACT CTAATGGGGCAGGCAGAAATCCTTTATGCAAAGACATTCAAGGAAAAGTCACGACTCAACACAATCTTCAAAAAGATTGGGAAGCTCAAT TCCATCAGCAAGCTGGGAAAAGGCAAAATGCCGTGCCTCATTTGTATGAATCACCGGACCAACGAAAGCATTAGCCTTCCATTCCAGTGC AAGGGCAGATTTAGCACCCGAAGTCCCCTGGAACTTCAGATGCAAGAGGGCGAACACACCATCCGCAACATTGTGGAGAAAACCAGGCTT CCTGTGAATGTGACTGTGCCAAGCCCTCCACCGAGAAACCCATACGACCTCCACTTCATCCGTGAGGGGCACCGCTATAAGTTTGTGAAC ATCCAGACCAAGACGGTGGTGGTTTGCTGTGTGCTGCGGAACAACAAGATCCTCCCCATGCACTTTCCTTTGCACTTGACTGTCCCCAAG TTCAGCCTCCCAGAACACCTGGTGAAGGGAGAGAGCTGGCCCGAAACCCTGGTCCATCACTGGCTAGGTATCTGCCAAGAACAGTTCGAC ATCGATGAGTATTCACGGGCTGTCCGTGATGTGAAAACCGACTGGAATGAAGAATGCAAGAGCCCCAAGAAGGGTCGGTGCTCTGGCCAC AACCACGTGCCCAATTCGCTCAGCTACGCCCGCGATGAGCTCACCCAGTCCTTCCACCGACTCTCGGTCTGTGTGTATGGCAACAATCTC CATGGCAACAGTGAGGTGAACCTTCATGGTTGCAGGGACCTGGGGGGAGATTGGGCTCCCTTTCCTCATGACATCCTGCCCTATCAGGAC TCTGGAGATAGTGGGAGCGACTACCTTTTCCCAGAAGCTAGTGAAGAATCAGCAGGCATCCCGGGAAAGTCAGAACTTCCCTACGAAGAG CTGTGGCTGGAGGAAGGCAAGCCCAGCCATCAGCCTCTCACTCGCTCTCTGAGCGAGAAGAACAGATGTGATCAGTTTAGAGGTTCTGTC CGATCCAAATGTGCGACTTCTCCTCTTCCCATCCCTGGGACTCTGGGAGCAGCAGTGAAGTCTTCAGATACTGCCCTACCTCCACCTCCA GTGCCTCCCAAATCTGAAGCCGTCAGAGAAGAATGCCGGCTCCTGAACGCCCCACCTGTTCCACCCCGAAGCGCAAAGCCTTTGTCCACC AGTCCCTCCATCCCTCCTCGCACAGTCAAGCCAGCGCGGCAACAGACTCGCTCTCCCAGCCCCACCTTGTCCTACTATTCTTCAGGGCTA CACAACATCAGCGTCACTAAAACTGACACAAATCCTTCTGAAAGCACTCCTGTTTCCTGCTATCCATGTAACCGAGTGAAAACTGATTCT GTGGACCTGAAATCCCCGTTTGGAAGTCCTTCTGCTGAAGCTGTGTCCTCTCGGCTCTCATGGCCTAACCATTATTCAGGAGCATCAGAA AGCCAGACCAGGAGTGACTTCCTGCTGGATCCAAGCAGGAGTTATAGTTACCCTAGACAAAAGACGCCAGGCACACCAAAGAGAAACTGC CCAGCACCTTTTGATTTTGATGGCTGTGAGCTCCTGGCCAGCCCCACTAGCCCAGTCACTGCAGAATTCAGTAGCAGCGTCTCTGGTTGT CCCAAGTCAGCCAGCTACTCTCTGGAGAGCACAGATGTGAAATCTCTTGCAGCTGGTGTGACAAAGCAGAGTACGTCATGCCCTGCCTTA CCCCCCAGGGCTCCAAAACTAGTGGAAGAGAAGGTCGCCTCCGAAACATCTCCTTTGCCTCTGAAAATTGATGGTGCTGAGGAAGACCCC AAGTCTGGGTCACCAGATCTCTCGGAGGACCAGTATTTTGTTAAAAAGGGCATGCAGGACATCTTCTCTGCCTCCTACCCTTTCTCATCT CCGCTCCATCTCCAGCTGGCCCCCAGATCCTGTGGCGACGGTTCCCCATGGCAGCCACCTGCTGACCTATCAGGACTCTCTATAGAGGAA GTGTCCAAGTCACTACGGTTCATTGGTTTGTCCGAAGATGTCATATCATTCTTTGTTACTGAAAAGATTGATGGGAACCTGCTTGTTCAG CTAACGGAAGAAATCCTCTCAGAGGATTTCAAATTGAGCAAATTGCAGGTGAAGAAGATAATGCAATTCATTAATGGCTGGAGGCCCAAA ATATAGCCAAATAACCCCCGGCCAGCATGGAACAAAACTGATCAATGCGTGTGCTAGAAGGGGTGGGCTGGGACACAATTTCATGTTTTT GCACTAAAAACCTTCTCTGTAAATAGGGATAAGAGAAACTCTTACTATGCAGATTACGTTTTTGAATGGTGAACAGGCTATTTTGTACAT CAATAAAAATGCTGTACAGAACACTTGGAGGTGTGCCTTGTACGTCACTCAACAAACACTCAGCAGCTGCTAAAAGAAAAAAAGGCATGT GCAGAGAAATCATTCTTACCCAAGTAGGTTTATGTGAGAAGGTATGATATTTATTACAAAATAGCCAAAGCTGGAAGACATAAAAATCTT >5302_5302_1_AP3S2-GAREM_AP3S2_chr15_90414707_ENST00000336418_GAREM_chr18_29868166_ENST00000269209_length(amino acids)=868AA_BP=123 MREPWLAKMIQAILVFNNHGKPRLVRFYQRFPEEIQQQIVRETFHLVLKRDDNICNFLEGGSLIGGSDYKLIYRHYATLYFVFCVDSSES ELGILDLIQVFVETLDKCFENVCELDLIFHMDKVASGECNEDTEVYNITLCTGDELTLMGQAEILYAKTFKEKSRLNTIFKKIGKLNSIS KLGKGKMPCLICMNHRTNESISLPFQCKGRFSTRSPLELQMQEGEHTIRNIVEKTRLPVNVTVPSPPPRNPYDLHFIREGHRYKFVNIQT KTVVVCCVLRNNKILPMHFPLHLTVPKFSLPEHLVKGESWPETLVHHWLGICQEQFDIDEYSRAVRDVKTDWNEECKSPKKGRCSGHNHV PNSLSYARDELTQSFHRLSVCVYGNNLHGNSEVNLHGCRDLGGDWAPFPHDILPYQDSGDSGSDYLFPEASEESAGIPGKSELPYEELWL EEGKPSHQPLTRSLSEKNRCDQFRGSVRSKCATSPLPIPGTLGAAVKSSDTALPPPPVPPKSEAVREECRLLNAPPVPPRSAKPLSTSPS IPPRTVKPARQQTRSPSPTLSYYSSGLHNISVTKTDTNPSESTPVSCYPCNRVKTDSVDLKSPFGSPSAEAVSSRLSWPNHYSGASESQT RSDFLLDPSRSYSYPRQKTPGTPKRNCPAPFDFDGCELLASPTSPVTAEFSSSVSGCPKSASYSLESTDVKSLAAGVTKQSTSCPALPPR APKLVEEKVASETSPLPLKIDGAEEDPKSGSPDLSEDQYFVKKGMQDIFSASYPFSSPLHLQLAPRSCGDGSPWQPPADLSGLSIEEVSK -------------------------------------------------------------- >5302_5302_2_AP3S2-GAREM_AP3S2_chr15_90414707_ENST00000336418_GAREM_chr18_29868166_ENST00000399218_length(transcript)=7322nt_BP=738nt ACGTTCTGCGAGCGCTAAGGGGATGGCGGGAGTGCATGATTTGGAGCGGGCGGTGAGAAAAGCAAGCTCCCGCCGCCTCTCCGTTTTGGC AACCCGGCTGACGGTCGTTTCGGCTTCTGGGGCCAGCCGTCGGTCTGGGCGAGGGACATAGATCCGGATTCGCATCCTGACTGGCCAACC AACGCTGGCCGAGGTGACCACTCTCCTCGGCATCCGCACCTGCCCTCCAAGGCGTCAGAGAGGCCGGACCCTTGGGTGCTAGGGCTCGTG AGCGCCGGGGCCAAGTTTCCGAGTGCCGCTCTCAGCAGCGCACCAACCGGAAGTGATCGTGTTGTGGCGGAAGGAGGAGCTTTCTGGGAG TAGCCGGTGCTGAGAGAACCGTGGCTGGCAAAGATGATTCAGGCGATTCTGGTTTTCAACAACCATGGGAAGCCACGGCTAGTCCGCTTC TACCAGCGTTTCCCAGAAGAAATTCAACAGCAGATTGTTCGAGAGACTTTCCATCTAGTCCTCAAGCGGGATGACAACATCTGTAACTTC TTGGAGGGTGGAAGTTTGATTGGTGGCTCTGACTACAAACTGATCTACCGGCACTATGCTACCCTCTACTTTGTATTTTGTGTGGATTCC TCAGAGAGTGAACTTGGAATCTTGGACCTCATCCAGGTTTTTGTGGAAACTCTGGATAAGTGTTTCGAAAATGTGTGTGAATTGGATTTG ATCTTCCATATGGATAAGGTTGCTTCAGGTGAATGCAATGAAGACACTGAAGTTTACAACATCACCCTGTGTACTGGGGATGAACTCACT CTAATGGGGCAGGCAGAAATCCTTTATGCAAAGACATTCAAGGAAAAGTCACGACTCAACACAATCTTCAAAAAGATTGGGAAGCTCAAT TCCATCAGCAAGCTGGGAAAAGGCAAAATGCCGTGCCTCATTTGTATGAATCACCGGACCAACGAAAGCATTAGCCTTCCATTCCAGTGC AAGGGCAGATTTAGCACCCGAAGTCCCCTGGAACTTCAGATGCAAGAGGGCGAACACACCATCCGCAACATTGTGGAGAAAACCAGGCTT CCTGTGAATGTGACTGTGCCAAGCCCTCCACCGAGAAACCCATACGACCTCCACTTCATCCGTGAGGGGCACCGCTATAAGTTTGTGAAC ATCCAGACCAAGACGGTGGTGGTTTGCTGTGTGCTGCGGAACAACAAGATCCTCCCCATGCACTTTCCTTTGCACTTGACTGTCCCCAAG TTCAGCCTCCCAGAACACCTGGTGAAGGGAGAGAGCTGGCCCGAAACCCTGGTCCATCACTGGCTAGGTATCTGCCAAGAACAGTTCGAC ATCGATGAGTATTCACGGGCTGTCCGTGATGTGAAAACCGACTGGAATGAAGAATGCAAGAGCCCCAAGAAGGGTCGGTGCTCTGGCCAC AACCACGTGCCCAATTCGCTCAGCTACGCCCGCGATGAGCTCACCCAGTCCTTCCACCGACTCTCGGTCTGTGTGTATGGCAACAATCTC CATGGCAACAGTGAGGTGAACCTTCATGGTTGCAGGGACCTGGGGGGAGATTGGGCTCCCTTTCCTCATGACATCCTGCCCTATCAGGAC TCTGGAGATAGTGGGAGCGACTACCTTTTCCCAGAAGCTAGTGAAGAATCAGCAGGCATCCCGGGAAAGTCAGAACTTCCCTACGAAGAG CTGTGGCTGGAGGAAGGCAAGCCCAGCCATCAGCCTCTCACTCGCTCTCTGAGCGAGAAGAACAGATGTGATCAGTTTAGAGGTTCTGTC CGATCCAAATGTGCGACTTCTCCTCTTCCCATCCCTGGGACTCTGGGAGCAGCAGTGAAGTCTTCAGATACTGCCCTACCTCCACCTCCA GTGCCTCCCAAATCTGAAGCCGTCAGAGAAGAATGCCGGCTCCTGAACGCCCCACCTGTTCCACCCCGAAGCGCAAAGCCTTTGTCCACC AGTCCCTCCATCCCTCCTCGCACAGTCAAGCCAGCGCGGCAACAGACTCGCTCTCCCAGCCCCACCTTGTCCTACTATTCTTCAGGGCTA CACAACATCGTCACTAAAACTGACACAAATCCTTCTGAAAGCACTCCTGTTTCCTGCTATCCATGTAACCGAGTGAAAACTGATTCTGTG GACCTGAAATCCCCGTTTGGAAGTCCTTCTGCTGAAGCTGTGTCCTCTCGGCTCTCATGGCCTAACCATTATTCAGGAGCATCAGAAAGC CAGACCAGGAGTGACTTCCTGCTGGATCCAAGCAGGAGTTATAGTTACCCTAGACAAAAGACGCCAGGCACACCAAAGAGAAACTGCCCA GCACCTTTTGATTTTGATGGCTGTGAGCTCCTGGCCAGCCCCACTAGCCCAGTCACTGCAGAATTCAGTAGCAGCGTCTCTGGTTGTCCC AAGTCAGCCAGCTACTCTCTGGAGAGCACAGATGTGAAATCTCTTGCAGCTGGTGTGACAAAGCAGAGTACGTCATGCCCTGCCTTACCC CCCAGGGCTCCAAAACTAGTGGAAGAGAAGGTCGCCTCCGAAACATCTCCTTTGCCTCTGAAAATTGATGGTGCTGAGGAAGACCCCAAG TCTGGGTCACCAGATCTCTCGGAGGACCAGTATTTTGTTAAAAAGGGCATGCAGGACATCTTCTCTGCCTCCTACCCTTTCTCATCTCCG CTCCATCTCCAGCTGGCCCCCAGATCCTGTGGCGACGGTTCCCCATGGCAGCCACCTGCTGACCTATCAGGACTCTCTATAGAGGAAGTG TCCAAGTCACTACGGTTCATTGGTTTGTCCGAAGATGTCATATCATTCTTTGTTACTGAAAAGATTGATGGGAACCTGCTTGTTCAGCTA ACGGAAGAAATCCTCTCAGAGGATTTCAAATTGAGCAAATTGCAGGTGAAGAAGATAATGCAATTCATTAATGGCTGGAGGCCCAAAATA TAGCCAAATAACCCCCGGCCAGCATGGAACAAAACTGATCAATGCGTGTGCTAGAAGGGGTGGGCTGGGACACAATTTCATGTTTTTGCA CTAAAAACCTTCTCTGTAAATAGGGATAAGAGAAACTCTTACTATGCAGATTACGTTTTTGAATGGTGAACAGGCTATTTTGTACATCAA TAAAAATGCTGTACAGAACACTTGGAGGTGTGCCTTGTACGTCACTCAACAAACACTCAGCAGCTGCTAAAAGAAAAAAAGGCATGTGCA GAGAAATCATTCTTACCCAAGTAGGTTTATGTGAGAAGGTATGATATTTATTACAAAATAGCCAAAGCTGGAAGACATAAAAATCTTTAA AAAAAAAAAAAAAACACTTTTGAACAAGTCCCTTCTTTCAGGAGGGTTGACTTTAGACAATTAACTGTGTTCTGTGCTCTGTCATTCAGA TTGCTTCTTGCTAATTGTTTTACTCTTGTGCCTGAAAATGTTAGTGATACGAATTGACACTTTAATGTTGTATGCTTGGTGGGGATCTTT TTATCACAAGGCATTTTCCAAGAGTCATATGTTGATAAAGGGATATATGTTGTCCTTAGAAATCACACAAATCATGACCACAATAATTTA TCTGTAACTGCTGCTAATTTTATTGAGCAGAGAAAAAAGAATATACATATATAAACATGTATAGGTGCATACACAATACACCCGGATATG TTTTACACATAATTTTGATTCTGATATTTTAGATAACATCTGTTCACTTTTAAACAATCTGTTGAGGTTTTGGGACTGTTATCTACATTG ATTCTCTTAGGAATAGTGGACAGAATGACTCCAAAGATTCTCAGAACCCTGTCTCTTGAAGCTCAATCTTATTTGGGTTCATCACTGAAA ACTTAGAACAAATCAGTAAAGAATCCTGTATTGAAGAATTAAGTTTGAGTTTAAGCCCACTCACCGCAGGGCTGGTTTTTGCATGTAATA CTCCCATGATGTCTGGGGAAATGACAGTTTCTGTTGAATTATAATTCTCCGGTTTAAGGGTCTCCTTCCCCTGGTGTCTGATGGTGAGAG GTCTGAAGAGCATTTGTCAGAGTACATTAGGCATTCTCAACCTACTTCATGCTTTACGAGAGCTGAGAAATCAGACGCACCGGCCTTTAT TATTATATATGCTACATCTGTTGAGTATTTTTAAAATACCAATAAGAGGACTTGTTTATTTCATAAACCACTTCTTCCCTCTCTTTCAAA GAAAATACATTATTACCATACTTTTACATTAGTCTGAGAATTTTTGCTAAATATGATTAAGTATTCCAAAATATAATGGCGTCATTATTC TTGACTTTTTTAGAGAATATACATCTTAAGACTGTATTAGTTCTCAGAGCAAGGCATCATCTACTCCCCTGCACCTGAGAGTCTGGCCCC AGATTCCAGATGTGCGGACAGCCCATGACCGAGGTGCACACAGTGCCCTCTTGAATAGGAAGGTCAGCCAGTGAGGCGGCAGCATAACTT GCAGGATGGACTTATATCTTACCATCTCTTCCTGCTACCAAAATAAAAAAATAAATTGAAAGACAAGACCCACCAGTCTAGTTTTGTAGA CCTGTGAAATGTGTCTTTATTTCTTGGCATTAGAAGAAAGATATTTTTAATCCATATCGTGGTTTTAGAGTTGAAGTGAATTGATACCCA ATTTTCCATCTTAGATCTCCTTTATCAAAAAAAAAAGCATTTTTTTTCTCCTAACGTGTCTCCCAAAATGTAAATACTATAGGCAAAAAG AGTACCCTGTAAAATTCTCACACTGGAGCACCTCTTCAAAAGTCACAGATAACTCAATGAGGAAGTGCTGGTACTGCACTCACAGGACAT GAGACCTATGAAGCTTTCGTGTTTTGAAAGCATCCTTCTGTGTGAGGGGGACTGCCTCCCTTAGTAAAGTAAACCTCTCAGAACTTCTTT TTAAAATAAAAACAGACAAGATGCAGTTACTAAGCTGCAAGTTTTCATTGGCAAACCTAGCTGAATCCGTTTTAAAATACTTAGCACTCG GACACAATTCTCAAACTCAGGAAGAAGGAACAGGGTTGGTTTGGGTTTACTATAAAGGTTGCCTCACATAAACAACTGACTCCTTTTAGC GTTTTTTTTCTTTTTGTAAAAACTTTACACAAAATAGGGTTTTAAATTCTTTTTGCTTGTTTTGGACTTGGTGTATTTTTGTCAAGTTTA TATTGATTGGCAACGCAGAGACTCCTTGAGGGCAGGGACTGTGGCCTTTGATTCACTTATGCTACAGTCTAGTATCACTACAGTGCTGAG TAAAAGACACAGCCCCTGCCCTCTTGGAGATCATATTGTTTATATTTGAAATCTCAGTTGCTAAGAGTATGTATGTGTGAGTAAGAAAGA CGTGAAGTCCTATGGGCAGCTGGGTATATGGAGAATTACGTGTGTCCTGTCTTTAAAACGTCAGCCTCTATTAAGGGGTACAGAACACCC CAAGATCACTAAAACTTGGAATGTGTTGGAGGCAGAAAGTATCTCTCTCATTGCCTAGTGTTGTTGTTTTTTTGTTTTTTGTTTTTTGTT TTTTTTACTGACCTGGAATTCTTTTAATTGTAATAAATATCTTCTGTCACAAATAAATGCCACAAATAAATGAAATTGCCATTCCTAAGC TGAGCACCTGTCTGTGAAGGACCTTGGTGTCCTGACTGGACAGAGCATTCATAGCTCCAAGAGAATCATGACAAGATATGCAAAGCAGGG ATAATAAGGAGAAAGCCCTTCCCTTTCGAGAAGCCCTTCCCTTTCACAGCCCTTCCCTGCGATTCTGCAGTGAAAAGTGATGCCCAGAGA TCCACACACAGAACCCTTCTAACCAGCCAGGTCAAGACTTATCATCTTATCTCCTCTGGCAGGTCCCCTGTAATCAAAAGAGAGGAAGTG TCTATCTAAACAAGACCCTTTTGGGTCCTTAGATTCATGGCAAAAATCATCATGGCCCCCATCAGAAAAGAAAATCAGCAATAAACCAAG CCAAGCAACTAAAATGTATAATGTGGACCTGACTCATGTTGGGAGGCAGAATTCAGACACTCACAGATCAATCTTGCAAGTTTTCTCTTC TTTAAGTTGAGCTGCTCAACTTTATGAACTGTGAAATTTACTTACATTCTTTCAACCCACATATATCATTGCAGTTTATGAAGTTGCAGT GAACTGCCCATTCAGCTAAATTGCAGTGTTTATTCTTGTCTCATGTCGAAATACAACAATCTTATGGGAAATATTATGACAGTCCGTTCC AACTGTTCTCAGACACATGCATAAACAGTCTCTGCTCACATTCCACAGCCACCTGCATGTTATCCATACAGCTCCCTGAGAAGTCCAGGG ATGGGAGGTGGGGTGTGGAAGGATGGAGGGTCCTTCATTTTCTAAACACTTTGTATAAGTCACTACTCATCGTGCCTAGCAAGTATAAGA TTAACATTTTGAATAACAAACTGGAAAACAAATAATCCTTCAAAGAACCTAGCGAACTGTTCAAAGGAAATTTTAATTTCAGTCTACCAG AAAAGTTAAATCTGTTGTTGGACGTAGGGGGCTTTCAGAAACATGCCTCTTATATCAATTTCCACTATCTTTCAAGTTACCTAAAGGCAC CAGGCTGCTTGAGCAAGAAGAATAAAAGGCCTAGAGTGCAAATTATGTGAAGTAGAGTTTTTAGATTGTGGGATTGTAATAATACGGGAT TCTCATGGTTACATCATGTTAAATCACACTGTTCAGTCTTTAAAACTTGGTGTTTTAAAATTTGTCTCATTGTGATAGCCAGAAACAAGG AATAAACGTGATTTCAGTTTAAACTATATACAAATATCTTCTGTAATTTTGCTGCTCTAATTTTTAGGCTATAAATTTTGTAATAGAGCT TATCAGATCGCAAATTTCCTTTGTTTACAATCTCATGTAGTAGGGCTCAGATAATTTCTTAGCTATAAACCTTTTCTCCCACTCTCATAT TGTTTCATTTAAAATATTTAAGCTAAGCCTAAAAATTGAAATCAGTTAAGAATTTGGAGAGTTTATCTTAAATGGAAATGGTGTATTCTT TTCAAAGAATTTTGTAACCATCTTTACAGTTTCTTTGCTTGGAAAACTTGGGTTGTTAACTACCAGTTAACAATGGCATTACTTTCCAAA ACGTTATCTAATGGGCCCAATGTGTACCTCAAGATAAACACAGTATGTTATGTCTAAAAATTTCCTTGTCTGTTGATTTAAATGGTTCTG >5302_5302_2_AP3S2-GAREM_AP3S2_chr15_90414707_ENST00000336418_GAREM_chr18_29868166_ENST00000399218_length(amino acids)=867AA_BP=123 MREPWLAKMIQAILVFNNHGKPRLVRFYQRFPEEIQQQIVRETFHLVLKRDDNICNFLEGGSLIGGSDYKLIYRHYATLYFVFCVDSSES ELGILDLIQVFVETLDKCFENVCELDLIFHMDKVASGECNEDTEVYNITLCTGDELTLMGQAEILYAKTFKEKSRLNTIFKKIGKLNSIS KLGKGKMPCLICMNHRTNESISLPFQCKGRFSTRSPLELQMQEGEHTIRNIVEKTRLPVNVTVPSPPPRNPYDLHFIREGHRYKFVNIQT KTVVVCCVLRNNKILPMHFPLHLTVPKFSLPEHLVKGESWPETLVHHWLGICQEQFDIDEYSRAVRDVKTDWNEECKSPKKGRCSGHNHV PNSLSYARDELTQSFHRLSVCVYGNNLHGNSEVNLHGCRDLGGDWAPFPHDILPYQDSGDSGSDYLFPEASEESAGIPGKSELPYEELWL EEGKPSHQPLTRSLSEKNRCDQFRGSVRSKCATSPLPIPGTLGAAVKSSDTALPPPPVPPKSEAVREECRLLNAPPVPPRSAKPLSTSPS IPPRTVKPARQQTRSPSPTLSYYSSGLHNIVTKTDTNPSESTPVSCYPCNRVKTDSVDLKSPFGSPSAEAVSSRLSWPNHYSGASESQTR SDFLLDPSRSYSYPRQKTPGTPKRNCPAPFDFDGCELLASPTSPVTAEFSSSVSGCPKSASYSLESTDVKSLAAGVTKQSTSCPALPPRA PKLVEEKVASETSPLPLKIDGAEEDPKSGSPDLSEDQYFVKKGMQDIFSASYPFSSPLHLQLAPRSCGDGSPWQPPADLSGLSIEEVSKS -------------------------------------------------------------- >5302_5302_3_AP3S2-GAREM_AP3S2_chr15_90414707_ENST00000558011_GAREM_chr18_29868166_ENST00000269209_length(transcript)=3035nt_BP=426nt GCTTTCTGGGAGTAGCCGGTGCTGAGAGAACCGTGGCTGGCAAAGATGATTCAGGCGATTCTGGTTTTCAACAACCATGGGAAGCCACGG CTAGTCCGCTTCTACCAGCGTTTCCCAGAAGAAATTCAACAGCAGATTGTTCGAGAGACTTTCCATCTAGTCCTCAAGCGGGATGACAAC ATCTGTAACTTCTTGGAGGGTGGAAGTTTGATTGGTGGCTCTGACTACAAACTGATCTACCGGCACTATGCTACCCTCTACTTTGTATTT TGTGTGGATTCCTCAGAGAGTGAACTTGGAATCTTGGACCTCATCCAGGTACATCTGGAAGTTGTTTTCTTCATAGCTCCCAAGGTTTTT GTGGAAACTCTGGATAAGTGTTTCGAAAATGTGTGTGAATTGGATTTGATCTTCCATATGGATAAGGTTGCTTCAGGTGAATGCAATGAA GACACTGAAGTTTACAACATCACCCTGTGTACTGGGGATGAACTCACTCTAATGGGGCAGGCAGAAATCCTTTATGCAAAGACATTCAAG GAAAAGTCACGACTCAACACAATCTTCAAAAAGATTGGGAAGCTCAATTCCATCAGCAAGCTGGGAAAAGGCAAAATGCCGTGCCTCATT TGTATGAATCACCGGACCAACGAAAGCATTAGCCTTCCATTCCAGTGCAAGGGCAGATTTAGCACCCGAAGTCCCCTGGAACTTCAGATG CAAGAGGGCGAACACACCATCCGCAACATTGTGGAGAAAACCAGGCTTCCTGTGAATGTGACTGTGCCAAGCCCTCCACCGAGAAACCCA TACGACCTCCACTTCATCCGTGAGGGGCACCGCTATAAGTTTGTGAACATCCAGACCAAGACGGTGGTGGTTTGCTGTGTGCTGCGGAAC AACAAGATCCTCCCCATGCACTTTCCTTTGCACTTGACTGTCCCCAAGTTCAGCCTCCCAGAACACCTGGTGAAGGGAGAGAGCTGGCCC GAAACCCTGGTCCATCACTGGCTAGGTATCTGCCAAGAACAGTTCGACATCGATGAGTATTCACGGGCTGTCCGTGATGTGAAAACCGAC TGGAATGAAGAATGCAAGAGCCCCAAGAAGGGTCGGTGCTCTGGCCACAACCACGTGCCCAATTCGCTCAGCTACGCCCGCGATGAGCTC ACCCAGTCCTTCCACCGACTCTCGGTCTGTGTGTATGGCAACAATCTCCATGGCAACAGTGAGGTGAACCTTCATGGTTGCAGGGACCTG GGGGGAGATTGGGCTCCCTTTCCTCATGACATCCTGCCCTATCAGGACTCTGGAGATAGTGGGAGCGACTACCTTTTCCCAGAAGCTAGT GAAGAATCAGCAGGCATCCCGGGAAAGTCAGAACTTCCCTACGAAGAGCTGTGGCTGGAGGAAGGCAAGCCCAGCCATCAGCCTCTCACT CGCTCTCTGAGCGAGAAGAACAGATGTGATCAGTTTAGAGGTTCTGTCCGATCCAAATGTGCGACTTCTCCTCTTCCCATCCCTGGGACT CTGGGAGCAGCAGTGAAGTCTTCAGATACTGCCCTACCTCCACCTCCAGTGCCTCCCAAATCTGAAGCCGTCAGAGAAGAATGCCGGCTC CTGAACGCCCCACCTGTTCCACCCCGAAGCGCAAAGCCTTTGTCCACCAGTCCCTCCATCCCTCCTCGCACAGTCAAGCCAGCGCGGCAA CAGACTCGCTCTCCCAGCCCCACCTTGTCCTACTATTCTTCAGGGCTACACAACATCAGCGTCACTAAAACTGACACAAATCCTTCTGAA AGCACTCCTGTTTCCTGCTATCCATGTAACCGAGTGAAAACTGATTCTGTGGACCTGAAATCCCCGTTTGGAAGTCCTTCTGCTGAAGCT GTGTCCTCTCGGCTCTCATGGCCTAACCATTATTCAGGAGCATCAGAAAGCCAGACCAGGAGTGACTTCCTGCTGGATCCAAGCAGGAGT TATAGTTACCCTAGACAAAAGACGCCAGGCACACCAAAGAGAAACTGCCCAGCACCTTTTGATTTTGATGGCTGTGAGCTCCTGGCCAGC CCCACTAGCCCAGTCACTGCAGAATTCAGTAGCAGCGTCTCTGGTTGTCCCAAGTCAGCCAGCTACTCTCTGGAGAGCACAGATGTGAAA TCTCTTGCAGCTGGTGTGACAAAGCAGAGTACGTCATGCCCTGCCTTACCCCCCAGGGCTCCAAAACTAGTGGAAGAGAAGGTCGCCTCC GAAACATCTCCTTTGCCTCTGAAAATTGATGGTGCTGAGGAAGACCCCAAGTCTGGGTCACCAGATCTCTCGGAGGACCAGTATTTTGTT AAAAAGGGCATGCAGGACATCTTCTCTGCCTCCTACCCTTTCTCATCTCCGCTCCATCTCCAGCTGGCCCCCAGATCCTGTGGCGACGGT TCCCCATGGCAGCCACCTGCTGACCTATCAGGACTCTCTATAGAGGAAGTGTCCAAGTCACTACGGTTCATTGGTTTGTCCGAAGATGTC ATATCATTCTTTGTTACTGAAAAGATTGATGGGAACCTGCTTGTTCAGCTAACGGAAGAAATCCTCTCAGAGGATTTCAAATTGAGCAAA TTGCAGGTGAAGAAGATAATGCAATTCATTAATGGCTGGAGGCCCAAAATATAGCCAAATAACCCCCGGCCAGCATGGAACAAAACTGAT CAATGCGTGTGCTAGAAGGGGTGGGCTGGGACACAATTTCATGTTTTTGCACTAAAAACCTTCTCTGTAAATAGGGATAAGAGAAACTCT TACTATGCAGATTACGTTTTTGAATGGTGAACAGGCTATTTTGTACATCAATAAAAATGCTGTACAGAACACTTGGAGGTGTGCCTTGTA CGTCACTCAACAAACACTCAGCAGCTGCTAAAAGAAAAAAAGGCATGTGCAGAGAAATCATTCTTACCCAAGTAGGTTTATGTGAGAAGG >5302_5302_3_AP3S2-GAREM_AP3S2_chr15_90414707_ENST00000558011_GAREM_chr18_29868166_ENST00000269209_length(amino acids)=880AA_BP=135 MREPWLAKMIQAILVFNNHGKPRLVRFYQRFPEEIQQQIVRETFHLVLKRDDNICNFLEGGSLIGGSDYKLIYRHYATLYFVFCVDSSES ELGILDLIQVHLEVVFFIAPKVFVETLDKCFENVCELDLIFHMDKVASGECNEDTEVYNITLCTGDELTLMGQAEILYAKTFKEKSRLNT IFKKIGKLNSISKLGKGKMPCLICMNHRTNESISLPFQCKGRFSTRSPLELQMQEGEHTIRNIVEKTRLPVNVTVPSPPPRNPYDLHFIR EGHRYKFVNIQTKTVVVCCVLRNNKILPMHFPLHLTVPKFSLPEHLVKGESWPETLVHHWLGICQEQFDIDEYSRAVRDVKTDWNEECKS PKKGRCSGHNHVPNSLSYARDELTQSFHRLSVCVYGNNLHGNSEVNLHGCRDLGGDWAPFPHDILPYQDSGDSGSDYLFPEASEESAGIP GKSELPYEELWLEEGKPSHQPLTRSLSEKNRCDQFRGSVRSKCATSPLPIPGTLGAAVKSSDTALPPPPVPPKSEAVREECRLLNAPPVP PRSAKPLSTSPSIPPRTVKPARQQTRSPSPTLSYYSSGLHNISVTKTDTNPSESTPVSCYPCNRVKTDSVDLKSPFGSPSAEAVSSRLSW PNHYSGASESQTRSDFLLDPSRSYSYPRQKTPGTPKRNCPAPFDFDGCELLASPTSPVTAEFSSSVSGCPKSASYSLESTDVKSLAAGVT KQSTSCPALPPRAPKLVEEKVASETSPLPLKIDGAEEDPKSGSPDLSEDQYFVKKGMQDIFSASYPFSSPLHLQLAPRSCGDGSPWQPPA -------------------------------------------------------------- >5302_5302_4_AP3S2-GAREM_AP3S2_chr15_90414707_ENST00000558011_GAREM_chr18_29868166_ENST00000399218_length(transcript)=7010nt_BP=426nt GCTTTCTGGGAGTAGCCGGTGCTGAGAGAACCGTGGCTGGCAAAGATGATTCAGGCGATTCTGGTTTTCAACAACCATGGGAAGCCACGG CTAGTCCGCTTCTACCAGCGTTTCCCAGAAGAAATTCAACAGCAGATTGTTCGAGAGACTTTCCATCTAGTCCTCAAGCGGGATGACAAC ATCTGTAACTTCTTGGAGGGTGGAAGTTTGATTGGTGGCTCTGACTACAAACTGATCTACCGGCACTATGCTACCCTCTACTTTGTATTT TGTGTGGATTCCTCAGAGAGTGAACTTGGAATCTTGGACCTCATCCAGGTACATCTGGAAGTTGTTTTCTTCATAGCTCCCAAGGTTTTT GTGGAAACTCTGGATAAGTGTTTCGAAAATGTGTGTGAATTGGATTTGATCTTCCATATGGATAAGGTTGCTTCAGGTGAATGCAATGAA GACACTGAAGTTTACAACATCACCCTGTGTACTGGGGATGAACTCACTCTAATGGGGCAGGCAGAAATCCTTTATGCAAAGACATTCAAG GAAAAGTCACGACTCAACACAATCTTCAAAAAGATTGGGAAGCTCAATTCCATCAGCAAGCTGGGAAAAGGCAAAATGCCGTGCCTCATT TGTATGAATCACCGGACCAACGAAAGCATTAGCCTTCCATTCCAGTGCAAGGGCAGATTTAGCACCCGAAGTCCCCTGGAACTTCAGATG CAAGAGGGCGAACACACCATCCGCAACATTGTGGAGAAAACCAGGCTTCCTGTGAATGTGACTGTGCCAAGCCCTCCACCGAGAAACCCA TACGACCTCCACTTCATCCGTGAGGGGCACCGCTATAAGTTTGTGAACATCCAGACCAAGACGGTGGTGGTTTGCTGTGTGCTGCGGAAC AACAAGATCCTCCCCATGCACTTTCCTTTGCACTTGACTGTCCCCAAGTTCAGCCTCCCAGAACACCTGGTGAAGGGAGAGAGCTGGCCC GAAACCCTGGTCCATCACTGGCTAGGTATCTGCCAAGAACAGTTCGACATCGATGAGTATTCACGGGCTGTCCGTGATGTGAAAACCGAC TGGAATGAAGAATGCAAGAGCCCCAAGAAGGGTCGGTGCTCTGGCCACAACCACGTGCCCAATTCGCTCAGCTACGCCCGCGATGAGCTC ACCCAGTCCTTCCACCGACTCTCGGTCTGTGTGTATGGCAACAATCTCCATGGCAACAGTGAGGTGAACCTTCATGGTTGCAGGGACCTG GGGGGAGATTGGGCTCCCTTTCCTCATGACATCCTGCCCTATCAGGACTCTGGAGATAGTGGGAGCGACTACCTTTTCCCAGAAGCTAGT GAAGAATCAGCAGGCATCCCGGGAAAGTCAGAACTTCCCTACGAAGAGCTGTGGCTGGAGGAAGGCAAGCCCAGCCATCAGCCTCTCACT CGCTCTCTGAGCGAGAAGAACAGATGTGATCAGTTTAGAGGTTCTGTCCGATCCAAATGTGCGACTTCTCCTCTTCCCATCCCTGGGACT CTGGGAGCAGCAGTGAAGTCTTCAGATACTGCCCTACCTCCACCTCCAGTGCCTCCCAAATCTGAAGCCGTCAGAGAAGAATGCCGGCTC CTGAACGCCCCACCTGTTCCACCCCGAAGCGCAAAGCCTTTGTCCACCAGTCCCTCCATCCCTCCTCGCACAGTCAAGCCAGCGCGGCAA CAGACTCGCTCTCCCAGCCCCACCTTGTCCTACTATTCTTCAGGGCTACACAACATCGTCACTAAAACTGACACAAATCCTTCTGAAAGC ACTCCTGTTTCCTGCTATCCATGTAACCGAGTGAAAACTGATTCTGTGGACCTGAAATCCCCGTTTGGAAGTCCTTCTGCTGAAGCTGTG TCCTCTCGGCTCTCATGGCCTAACCATTATTCAGGAGCATCAGAAAGCCAGACCAGGAGTGACTTCCTGCTGGATCCAAGCAGGAGTTAT AGTTACCCTAGACAAAAGACGCCAGGCACACCAAAGAGAAACTGCCCAGCACCTTTTGATTTTGATGGCTGTGAGCTCCTGGCCAGCCCC ACTAGCCCAGTCACTGCAGAATTCAGTAGCAGCGTCTCTGGTTGTCCCAAGTCAGCCAGCTACTCTCTGGAGAGCACAGATGTGAAATCT CTTGCAGCTGGTGTGACAAAGCAGAGTACGTCATGCCCTGCCTTACCCCCCAGGGCTCCAAAACTAGTGGAAGAGAAGGTCGCCTCCGAA ACATCTCCTTTGCCTCTGAAAATTGATGGTGCTGAGGAAGACCCCAAGTCTGGGTCACCAGATCTCTCGGAGGACCAGTATTTTGTTAAA AAGGGCATGCAGGACATCTTCTCTGCCTCCTACCCTTTCTCATCTCCGCTCCATCTCCAGCTGGCCCCCAGATCCTGTGGCGACGGTTCC CCATGGCAGCCACCTGCTGACCTATCAGGACTCTCTATAGAGGAAGTGTCCAAGTCACTACGGTTCATTGGTTTGTCCGAAGATGTCATA TCATTCTTTGTTACTGAAAAGATTGATGGGAACCTGCTTGTTCAGCTAACGGAAGAAATCCTCTCAGAGGATTTCAAATTGAGCAAATTG CAGGTGAAGAAGATAATGCAATTCATTAATGGCTGGAGGCCCAAAATATAGCCAAATAACCCCCGGCCAGCATGGAACAAAACTGATCAA TGCGTGTGCTAGAAGGGGTGGGCTGGGACACAATTTCATGTTTTTGCACTAAAAACCTTCTCTGTAAATAGGGATAAGAGAAACTCTTAC TATGCAGATTACGTTTTTGAATGGTGAACAGGCTATTTTGTACATCAATAAAAATGCTGTACAGAACACTTGGAGGTGTGCCTTGTACGT CACTCAACAAACACTCAGCAGCTGCTAAAAGAAAAAAAGGCATGTGCAGAGAAATCATTCTTACCCAAGTAGGTTTATGTGAGAAGGTAT GATATTTATTACAAAATAGCCAAAGCTGGAAGACATAAAAATCTTTAAAAAAAAAAAAAAAACACTTTTGAACAAGTCCCTTCTTTCAGG AGGGTTGACTTTAGACAATTAACTGTGTTCTGTGCTCTGTCATTCAGATTGCTTCTTGCTAATTGTTTTACTCTTGTGCCTGAAAATGTT AGTGATACGAATTGACACTTTAATGTTGTATGCTTGGTGGGGATCTTTTTATCACAAGGCATTTTCCAAGAGTCATATGTTGATAAAGGG ATATATGTTGTCCTTAGAAATCACACAAATCATGACCACAATAATTTATCTGTAACTGCTGCTAATTTTATTGAGCAGAGAAAAAAGAAT ATACATATATAAACATGTATAGGTGCATACACAATACACCCGGATATGTTTTACACATAATTTTGATTCTGATATTTTAGATAACATCTG TTCACTTTTAAACAATCTGTTGAGGTTTTGGGACTGTTATCTACATTGATTCTCTTAGGAATAGTGGACAGAATGACTCCAAAGATTCTC AGAACCCTGTCTCTTGAAGCTCAATCTTATTTGGGTTCATCACTGAAAACTTAGAACAAATCAGTAAAGAATCCTGTATTGAAGAATTAA GTTTGAGTTTAAGCCCACTCACCGCAGGGCTGGTTTTTGCATGTAATACTCCCATGATGTCTGGGGAAATGACAGTTTCTGTTGAATTAT AATTCTCCGGTTTAAGGGTCTCCTTCCCCTGGTGTCTGATGGTGAGAGGTCTGAAGAGCATTTGTCAGAGTACATTAGGCATTCTCAACC TACTTCATGCTTTACGAGAGCTGAGAAATCAGACGCACCGGCCTTTATTATTATATATGCTACATCTGTTGAGTATTTTTAAAATACCAA TAAGAGGACTTGTTTATTTCATAAACCACTTCTTCCCTCTCTTTCAAAGAAAATACATTATTACCATACTTTTACATTAGTCTGAGAATT TTTGCTAAATATGATTAAGTATTCCAAAATATAATGGCGTCATTATTCTTGACTTTTTTAGAGAATATACATCTTAAGACTGTATTAGTT CTCAGAGCAAGGCATCATCTACTCCCCTGCACCTGAGAGTCTGGCCCCAGATTCCAGATGTGCGGACAGCCCATGACCGAGGTGCACACA GTGCCCTCTTGAATAGGAAGGTCAGCCAGTGAGGCGGCAGCATAACTTGCAGGATGGACTTATATCTTACCATCTCTTCCTGCTACCAAA ATAAAAAAATAAATTGAAAGACAAGACCCACCAGTCTAGTTTTGTAGACCTGTGAAATGTGTCTTTATTTCTTGGCATTAGAAGAAAGAT ATTTTTAATCCATATCGTGGTTTTAGAGTTGAAGTGAATTGATACCCAATTTTCCATCTTAGATCTCCTTTATCAAAAAAAAAAGCATTT TTTTTCTCCTAACGTGTCTCCCAAAATGTAAATACTATAGGCAAAAAGAGTACCCTGTAAAATTCTCACACTGGAGCACCTCTTCAAAAG TCACAGATAACTCAATGAGGAAGTGCTGGTACTGCACTCACAGGACATGAGACCTATGAAGCTTTCGTGTTTTGAAAGCATCCTTCTGTG TGAGGGGGACTGCCTCCCTTAGTAAAGTAAACCTCTCAGAACTTCTTTTTAAAATAAAAACAGACAAGATGCAGTTACTAAGCTGCAAGT TTTCATTGGCAAACCTAGCTGAATCCGTTTTAAAATACTTAGCACTCGGACACAATTCTCAAACTCAGGAAGAAGGAACAGGGTTGGTTT GGGTTTACTATAAAGGTTGCCTCACATAAACAACTGACTCCTTTTAGCGTTTTTTTTCTTTTTGTAAAAACTTTACACAAAATAGGGTTT TAAATTCTTTTTGCTTGTTTTGGACTTGGTGTATTTTTGTCAAGTTTATATTGATTGGCAACGCAGAGACTCCTTGAGGGCAGGGACTGT GGCCTTTGATTCACTTATGCTACAGTCTAGTATCACTACAGTGCTGAGTAAAAGACACAGCCCCTGCCCTCTTGGAGATCATATTGTTTA TATTTGAAATCTCAGTTGCTAAGAGTATGTATGTGTGAGTAAGAAAGACGTGAAGTCCTATGGGCAGCTGGGTATATGGAGAATTACGTG TGTCCTGTCTTTAAAACGTCAGCCTCTATTAAGGGGTACAGAACACCCCAAGATCACTAAAACTTGGAATGTGTTGGAGGCAGAAAGTAT CTCTCTCATTGCCTAGTGTTGTTGTTTTTTTGTTTTTTGTTTTTTGTTTTTTTTACTGACCTGGAATTCTTTTAATTGTAATAAATATCT TCTGTCACAAATAAATGCCACAAATAAATGAAATTGCCATTCCTAAGCTGAGCACCTGTCTGTGAAGGACCTTGGTGTCCTGACTGGACA GAGCATTCATAGCTCCAAGAGAATCATGACAAGATATGCAAAGCAGGGATAATAAGGAGAAAGCCCTTCCCTTTCGAGAAGCCCTTCCCT TTCACAGCCCTTCCCTGCGATTCTGCAGTGAAAAGTGATGCCCAGAGATCCACACACAGAACCCTTCTAACCAGCCAGGTCAAGACTTAT CATCTTATCTCCTCTGGCAGGTCCCCTGTAATCAAAAGAGAGGAAGTGTCTATCTAAACAAGACCCTTTTGGGTCCTTAGATTCATGGCA AAAATCATCATGGCCCCCATCAGAAAAGAAAATCAGCAATAAACCAAGCCAAGCAACTAAAATGTATAATGTGGACCTGACTCATGTTGG GAGGCAGAATTCAGACACTCACAGATCAATCTTGCAAGTTTTCTCTTCTTTAAGTTGAGCTGCTCAACTTTATGAACTGTGAAATTTACT TACATTCTTTCAACCCACATATATCATTGCAGTTTATGAAGTTGCAGTGAACTGCCCATTCAGCTAAATTGCAGTGTTTATTCTTGTCTC ATGTCGAAATACAACAATCTTATGGGAAATATTATGACAGTCCGTTCCAACTGTTCTCAGACACATGCATAAACAGTCTCTGCTCACATT CCACAGCCACCTGCATGTTATCCATACAGCTCCCTGAGAAGTCCAGGGATGGGAGGTGGGGTGTGGAAGGATGGAGGGTCCTTCATTTTC TAAACACTTTGTATAAGTCACTACTCATCGTGCCTAGCAAGTATAAGATTAACATTTTGAATAACAAACTGGAAAACAAATAATCCTTCA AAGAACCTAGCGAACTGTTCAAAGGAAATTTTAATTTCAGTCTACCAGAAAAGTTAAATCTGTTGTTGGACGTAGGGGGCTTTCAGAAAC ATGCCTCTTATATCAATTTCCACTATCTTTCAAGTTACCTAAAGGCACCAGGCTGCTTGAGCAAGAAGAATAAAAGGCCTAGAGTGCAAA TTATGTGAAGTAGAGTTTTTAGATTGTGGGATTGTAATAATACGGGATTCTCATGGTTACATCATGTTAAATCACACTGTTCAGTCTTTA AAACTTGGTGTTTTAAAATTTGTCTCATTGTGATAGCCAGAAACAAGGAATAAACGTGATTTCAGTTTAAACTATATACAAATATCTTCT GTAATTTTGCTGCTCTAATTTTTAGGCTATAAATTTTGTAATAGAGCTTATCAGATCGCAAATTTCCTTTGTTTACAATCTCATGTAGTA GGGCTCAGATAATTTCTTAGCTATAAACCTTTTCTCCCACTCTCATATTGTTTCATTTAAAATATTTAAGCTAAGCCTAAAAATTGAAAT CAGTTAAGAATTTGGAGAGTTTATCTTAAATGGAAATGGTGTATTCTTTTCAAAGAATTTTGTAACCATCTTTACAGTTTCTTTGCTTGG AAAACTTGGGTTGTTAACTACCAGTTAACAATGGCATTACTTTCCAAAACGTTATCTAATGGGCCCAATGTGTACCTCAAGATAAACACA >5302_5302_4_AP3S2-GAREM_AP3S2_chr15_90414707_ENST00000558011_GAREM_chr18_29868166_ENST00000399218_length(amino acids)=879AA_BP=135 MREPWLAKMIQAILVFNNHGKPRLVRFYQRFPEEIQQQIVRETFHLVLKRDDNICNFLEGGSLIGGSDYKLIYRHYATLYFVFCVDSSES ELGILDLIQVHLEVVFFIAPKVFVETLDKCFENVCELDLIFHMDKVASGECNEDTEVYNITLCTGDELTLMGQAEILYAKTFKEKSRLNT IFKKIGKLNSISKLGKGKMPCLICMNHRTNESISLPFQCKGRFSTRSPLELQMQEGEHTIRNIVEKTRLPVNVTVPSPPPRNPYDLHFIR EGHRYKFVNIQTKTVVVCCVLRNNKILPMHFPLHLTVPKFSLPEHLVKGESWPETLVHHWLGICQEQFDIDEYSRAVRDVKTDWNEECKS PKKGRCSGHNHVPNSLSYARDELTQSFHRLSVCVYGNNLHGNSEVNLHGCRDLGGDWAPFPHDILPYQDSGDSGSDYLFPEASEESAGIP GKSELPYEELWLEEGKPSHQPLTRSLSEKNRCDQFRGSVRSKCATSPLPIPGTLGAAVKSSDTALPPPPVPPKSEAVREECRLLNAPPVP PRSAKPLSTSPSIPPRTVKPARQQTRSPSPTLSYYSSGLHNIVTKTDTNPSESTPVSCYPCNRVKTDSVDLKSPFGSPSAEAVSSRLSWP NHYSGASESQTRSDFLLDPSRSYSYPRQKTPGTPKRNCPAPFDFDGCELLASPTSPVTAEFSSSVSGCPKSASYSLESTDVKSLAAGVTK QSTSCPALPPRAPKLVEEKVASETSPLPLKIDGAEEDPKSGSPDLSEDQYFVKKGMQDIFSASYPFSSPLHLQLAPRSCGDGSPWQPPAD -------------------------------------------------------------- >5302_5302_5_AP3S2-GAREM_AP3S2_chr15_90414707_ENST00000560940_GAREM_chr18_29868166_ENST00000269209_length(transcript)=2986nt_BP=377nt AGCCGGTGCTGAGAGAACCGTGGCTGGCAAAGATGATTCAGGCGATTCTGGTTTTCAACAACCATGGGAAGCCACGGCTAGTCCGCTTCT ACCAGCGTTTCCCAGAAGAAATTCAACAGCAGATTGTTCGAGAGACTTTCCATCTAGTCCTCAAGCGGGATGACAACATCTGTAACTTCT TGGAGGGTGGAAGTTTGATTGGTGGCTCTGACTACAAACTGATCTACCGGCACTATGCTACCCTCTACTTTGTATTTTGTGTGGATTCCT CAGAGAGTGAACTTGGAATCTTGGACCTCATCCAGGTTTTTGTGGAAACTCTGGATAAGTGTTTCGAAAATGTGTGTGAATTGGATTTGA TCTTCCATATGGATAAGGTTGCTTCAGGTGAATGCAATGAAGACACTGAAGTTTACAACATCACCCTGTGTACTGGGGATGAACTCACTC TAATGGGGCAGGCAGAAATCCTTTATGCAAAGACATTCAAGGAAAAGTCACGACTCAACACAATCTTCAAAAAGATTGGGAAGCTCAATT CCATCAGCAAGCTGGGAAAAGGCAAAATGCCGTGCCTCATTTGTATGAATCACCGGACCAACGAAAGCATTAGCCTTCCATTCCAGTGCA AGGGCAGATTTAGCACCCGAAGTCCCCTGGAACTTCAGATGCAAGAGGGCGAACACACCATCCGCAACATTGTGGAGAAAACCAGGCTTC CTGTGAATGTGACTGTGCCAAGCCCTCCACCGAGAAACCCATACGACCTCCACTTCATCCGTGAGGGGCACCGCTATAAGTTTGTGAACA TCCAGACCAAGACGGTGGTGGTTTGCTGTGTGCTGCGGAACAACAAGATCCTCCCCATGCACTTTCCTTTGCACTTGACTGTCCCCAAGT TCAGCCTCCCAGAACACCTGGTGAAGGGAGAGAGCTGGCCCGAAACCCTGGTCCATCACTGGCTAGGTATCTGCCAAGAACAGTTCGACA TCGATGAGTATTCACGGGCTGTCCGTGATGTGAAAACCGACTGGAATGAAGAATGCAAGAGCCCCAAGAAGGGTCGGTGCTCTGGCCACA ACCACGTGCCCAATTCGCTCAGCTACGCCCGCGATGAGCTCACCCAGTCCTTCCACCGACTCTCGGTCTGTGTGTATGGCAACAATCTCC ATGGCAACAGTGAGGTGAACCTTCATGGTTGCAGGGACCTGGGGGGAGATTGGGCTCCCTTTCCTCATGACATCCTGCCCTATCAGGACT CTGGAGATAGTGGGAGCGACTACCTTTTCCCAGAAGCTAGTGAAGAATCAGCAGGCATCCCGGGAAAGTCAGAACTTCCCTACGAAGAGC TGTGGCTGGAGGAAGGCAAGCCCAGCCATCAGCCTCTCACTCGCTCTCTGAGCGAGAAGAACAGATGTGATCAGTTTAGAGGTTCTGTCC GATCCAAATGTGCGACTTCTCCTCTTCCCATCCCTGGGACTCTGGGAGCAGCAGTGAAGTCTTCAGATACTGCCCTACCTCCACCTCCAG TGCCTCCCAAATCTGAAGCCGTCAGAGAAGAATGCCGGCTCCTGAACGCCCCACCTGTTCCACCCCGAAGCGCAAAGCCTTTGTCCACCA GTCCCTCCATCCCTCCTCGCACAGTCAAGCCAGCGCGGCAACAGACTCGCTCTCCCAGCCCCACCTTGTCCTACTATTCTTCAGGGCTAC ACAACATCAGCGTCACTAAAACTGACACAAATCCTTCTGAAAGCACTCCTGTTTCCTGCTATCCATGTAACCGAGTGAAAACTGATTCTG TGGACCTGAAATCCCCGTTTGGAAGTCCTTCTGCTGAAGCTGTGTCCTCTCGGCTCTCATGGCCTAACCATTATTCAGGAGCATCAGAAA GCCAGACCAGGAGTGACTTCCTGCTGGATCCAAGCAGGAGTTATAGTTACCCTAGACAAAAGACGCCAGGCACACCAAAGAGAAACTGCC CAGCACCTTTTGATTTTGATGGCTGTGAGCTCCTGGCCAGCCCCACTAGCCCAGTCACTGCAGAATTCAGTAGCAGCGTCTCTGGTTGTC CCAAGTCAGCCAGCTACTCTCTGGAGAGCACAGATGTGAAATCTCTTGCAGCTGGTGTGACAAAGCAGAGTACGTCATGCCCTGCCTTAC CCCCCAGGGCTCCAAAACTAGTGGAAGAGAAGGTCGCCTCCGAAACATCTCCTTTGCCTCTGAAAATTGATGGTGCTGAGGAAGACCCCA AGTCTGGGTCACCAGATCTCTCGGAGGACCAGTATTTTGTTAAAAAGGGCATGCAGGACATCTTCTCTGCCTCCTACCCTTTCTCATCTC CGCTCCATCTCCAGCTGGCCCCCAGATCCTGTGGCGACGGTTCCCCATGGCAGCCACCTGCTGACCTATCAGGACTCTCTATAGAGGAAG TGTCCAAGTCACTACGGTTCATTGGTTTGTCCGAAGATGTCATATCATTCTTTGTTACTGAAAAGATTGATGGGAACCTGCTTGTTCAGC TAACGGAAGAAATCCTCTCAGAGGATTTCAAATTGAGCAAATTGCAGGTGAAGAAGATAATGCAATTCATTAATGGCTGGAGGCCCAAAA TATAGCCAAATAACCCCCGGCCAGCATGGAACAAAACTGATCAATGCGTGTGCTAGAAGGGGTGGGCTGGGACACAATTTCATGTTTTTG CACTAAAAACCTTCTCTGTAAATAGGGATAAGAGAAACTCTTACTATGCAGATTACGTTTTTGAATGGTGAACAGGCTATTTTGTACATC AATAAAAATGCTGTACAGAACACTTGGAGGTGTGCCTTGTACGTCACTCAACAAACACTCAGCAGCTGCTAAAAGAAAAAAAGGCATGTG CAGAGAAATCATTCTTACCCAAGTAGGTTTATGTGAGAAGGTATGATATTTATTACAAAATAGCCAAAGCTGGAAGACATAAAAATCTTT >5302_5302_5_AP3S2-GAREM_AP3S2_chr15_90414707_ENST00000560940_GAREM_chr18_29868166_ENST00000269209_length(amino acids)=868AA_BP=123 MREPWLAKMIQAILVFNNHGKPRLVRFYQRFPEEIQQQIVRETFHLVLKRDDNICNFLEGGSLIGGSDYKLIYRHYATLYFVFCVDSSES ELGILDLIQVFVETLDKCFENVCELDLIFHMDKVASGECNEDTEVYNITLCTGDELTLMGQAEILYAKTFKEKSRLNTIFKKIGKLNSIS KLGKGKMPCLICMNHRTNESISLPFQCKGRFSTRSPLELQMQEGEHTIRNIVEKTRLPVNVTVPSPPPRNPYDLHFIREGHRYKFVNIQT KTVVVCCVLRNNKILPMHFPLHLTVPKFSLPEHLVKGESWPETLVHHWLGICQEQFDIDEYSRAVRDVKTDWNEECKSPKKGRCSGHNHV PNSLSYARDELTQSFHRLSVCVYGNNLHGNSEVNLHGCRDLGGDWAPFPHDILPYQDSGDSGSDYLFPEASEESAGIPGKSELPYEELWL EEGKPSHQPLTRSLSEKNRCDQFRGSVRSKCATSPLPIPGTLGAAVKSSDTALPPPPVPPKSEAVREECRLLNAPPVPPRSAKPLSTSPS IPPRTVKPARQQTRSPSPTLSYYSSGLHNISVTKTDTNPSESTPVSCYPCNRVKTDSVDLKSPFGSPSAEAVSSRLSWPNHYSGASESQT RSDFLLDPSRSYSYPRQKTPGTPKRNCPAPFDFDGCELLASPTSPVTAEFSSSVSGCPKSASYSLESTDVKSLAAGVTKQSTSCPALPPR APKLVEEKVASETSPLPLKIDGAEEDPKSGSPDLSEDQYFVKKGMQDIFSASYPFSSPLHLQLAPRSCGDGSPWQPPADLSGLSIEEVSK -------------------------------------------------------------- >5302_5302_6_AP3S2-GAREM_AP3S2_chr15_90414707_ENST00000560940_GAREM_chr18_29868166_ENST00000399218_length(transcript)=6961nt_BP=377nt AGCCGGTGCTGAGAGAACCGTGGCTGGCAAAGATGATTCAGGCGATTCTGGTTTTCAACAACCATGGGAAGCCACGGCTAGTCCGCTTCT ACCAGCGTTTCCCAGAAGAAATTCAACAGCAGATTGTTCGAGAGACTTTCCATCTAGTCCTCAAGCGGGATGACAACATCTGTAACTTCT TGGAGGGTGGAAGTTTGATTGGTGGCTCTGACTACAAACTGATCTACCGGCACTATGCTACCCTCTACTTTGTATTTTGTGTGGATTCCT CAGAGAGTGAACTTGGAATCTTGGACCTCATCCAGGTTTTTGTGGAAACTCTGGATAAGTGTTTCGAAAATGTGTGTGAATTGGATTTGA TCTTCCATATGGATAAGGTTGCTTCAGGTGAATGCAATGAAGACACTGAAGTTTACAACATCACCCTGTGTACTGGGGATGAACTCACTC TAATGGGGCAGGCAGAAATCCTTTATGCAAAGACATTCAAGGAAAAGTCACGACTCAACACAATCTTCAAAAAGATTGGGAAGCTCAATT CCATCAGCAAGCTGGGAAAAGGCAAAATGCCGTGCCTCATTTGTATGAATCACCGGACCAACGAAAGCATTAGCCTTCCATTCCAGTGCA AGGGCAGATTTAGCACCCGAAGTCCCCTGGAACTTCAGATGCAAGAGGGCGAACACACCATCCGCAACATTGTGGAGAAAACCAGGCTTC CTGTGAATGTGACTGTGCCAAGCCCTCCACCGAGAAACCCATACGACCTCCACTTCATCCGTGAGGGGCACCGCTATAAGTTTGTGAACA TCCAGACCAAGACGGTGGTGGTTTGCTGTGTGCTGCGGAACAACAAGATCCTCCCCATGCACTTTCCTTTGCACTTGACTGTCCCCAAGT TCAGCCTCCCAGAACACCTGGTGAAGGGAGAGAGCTGGCCCGAAACCCTGGTCCATCACTGGCTAGGTATCTGCCAAGAACAGTTCGACA TCGATGAGTATTCACGGGCTGTCCGTGATGTGAAAACCGACTGGAATGAAGAATGCAAGAGCCCCAAGAAGGGTCGGTGCTCTGGCCACA ACCACGTGCCCAATTCGCTCAGCTACGCCCGCGATGAGCTCACCCAGTCCTTCCACCGACTCTCGGTCTGTGTGTATGGCAACAATCTCC ATGGCAACAGTGAGGTGAACCTTCATGGTTGCAGGGACCTGGGGGGAGATTGGGCTCCCTTTCCTCATGACATCCTGCCCTATCAGGACT CTGGAGATAGTGGGAGCGACTACCTTTTCCCAGAAGCTAGTGAAGAATCAGCAGGCATCCCGGGAAAGTCAGAACTTCCCTACGAAGAGC TGTGGCTGGAGGAAGGCAAGCCCAGCCATCAGCCTCTCACTCGCTCTCTGAGCGAGAAGAACAGATGTGATCAGTTTAGAGGTTCTGTCC GATCCAAATGTGCGACTTCTCCTCTTCCCATCCCTGGGACTCTGGGAGCAGCAGTGAAGTCTTCAGATACTGCCCTACCTCCACCTCCAG TGCCTCCCAAATCTGAAGCCGTCAGAGAAGAATGCCGGCTCCTGAACGCCCCACCTGTTCCACCCCGAAGCGCAAAGCCTTTGTCCACCA GTCCCTCCATCCCTCCTCGCACAGTCAAGCCAGCGCGGCAACAGACTCGCTCTCCCAGCCCCACCTTGTCCTACTATTCTTCAGGGCTAC ACAACATCGTCACTAAAACTGACACAAATCCTTCTGAAAGCACTCCTGTTTCCTGCTATCCATGTAACCGAGTGAAAACTGATTCTGTGG ACCTGAAATCCCCGTTTGGAAGTCCTTCTGCTGAAGCTGTGTCCTCTCGGCTCTCATGGCCTAACCATTATTCAGGAGCATCAGAAAGCC AGACCAGGAGTGACTTCCTGCTGGATCCAAGCAGGAGTTATAGTTACCCTAGACAAAAGACGCCAGGCACACCAAAGAGAAACTGCCCAG CACCTTTTGATTTTGATGGCTGTGAGCTCCTGGCCAGCCCCACTAGCCCAGTCACTGCAGAATTCAGTAGCAGCGTCTCTGGTTGTCCCA AGTCAGCCAGCTACTCTCTGGAGAGCACAGATGTGAAATCTCTTGCAGCTGGTGTGACAAAGCAGAGTACGTCATGCCCTGCCTTACCCC CCAGGGCTCCAAAACTAGTGGAAGAGAAGGTCGCCTCCGAAACATCTCCTTTGCCTCTGAAAATTGATGGTGCTGAGGAAGACCCCAAGT CTGGGTCACCAGATCTCTCGGAGGACCAGTATTTTGTTAAAAAGGGCATGCAGGACATCTTCTCTGCCTCCTACCCTTTCTCATCTCCGC TCCATCTCCAGCTGGCCCCCAGATCCTGTGGCGACGGTTCCCCATGGCAGCCACCTGCTGACCTATCAGGACTCTCTATAGAGGAAGTGT CCAAGTCACTACGGTTCATTGGTTTGTCCGAAGATGTCATATCATTCTTTGTTACTGAAAAGATTGATGGGAACCTGCTTGTTCAGCTAA CGGAAGAAATCCTCTCAGAGGATTTCAAATTGAGCAAATTGCAGGTGAAGAAGATAATGCAATTCATTAATGGCTGGAGGCCCAAAATAT AGCCAAATAACCCCCGGCCAGCATGGAACAAAACTGATCAATGCGTGTGCTAGAAGGGGTGGGCTGGGACACAATTTCATGTTTTTGCAC TAAAAACCTTCTCTGTAAATAGGGATAAGAGAAACTCTTACTATGCAGATTACGTTTTTGAATGGTGAACAGGCTATTTTGTACATCAAT AAAAATGCTGTACAGAACACTTGGAGGTGTGCCTTGTACGTCACTCAACAAACACTCAGCAGCTGCTAAAAGAAAAAAAGGCATGTGCAG AGAAATCATTCTTACCCAAGTAGGTTTATGTGAGAAGGTATGATATTTATTACAAAATAGCCAAAGCTGGAAGACATAAAAATCTTTAAA AAAAAAAAAAAAACACTTTTGAACAAGTCCCTTCTTTCAGGAGGGTTGACTTTAGACAATTAACTGTGTTCTGTGCTCTGTCATTCAGAT TGCTTCTTGCTAATTGTTTTACTCTTGTGCCTGAAAATGTTAGTGATACGAATTGACACTTTAATGTTGTATGCTTGGTGGGGATCTTTT TATCACAAGGCATTTTCCAAGAGTCATATGTTGATAAAGGGATATATGTTGTCCTTAGAAATCACACAAATCATGACCACAATAATTTAT CTGTAACTGCTGCTAATTTTATTGAGCAGAGAAAAAAGAATATACATATATAAACATGTATAGGTGCATACACAATACACCCGGATATGT TTTACACATAATTTTGATTCTGATATTTTAGATAACATCTGTTCACTTTTAAACAATCTGTTGAGGTTTTGGGACTGTTATCTACATTGA TTCTCTTAGGAATAGTGGACAGAATGACTCCAAAGATTCTCAGAACCCTGTCTCTTGAAGCTCAATCTTATTTGGGTTCATCACTGAAAA CTTAGAACAAATCAGTAAAGAATCCTGTATTGAAGAATTAAGTTTGAGTTTAAGCCCACTCACCGCAGGGCTGGTTTTTGCATGTAATAC TCCCATGATGTCTGGGGAAATGACAGTTTCTGTTGAATTATAATTCTCCGGTTTAAGGGTCTCCTTCCCCTGGTGTCTGATGGTGAGAGG TCTGAAGAGCATTTGTCAGAGTACATTAGGCATTCTCAACCTACTTCATGCTTTACGAGAGCTGAGAAATCAGACGCACCGGCCTTTATT ATTATATATGCTACATCTGTTGAGTATTTTTAAAATACCAATAAGAGGACTTGTTTATTTCATAAACCACTTCTTCCCTCTCTTTCAAAG AAAATACATTATTACCATACTTTTACATTAGTCTGAGAATTTTTGCTAAATATGATTAAGTATTCCAAAATATAATGGCGTCATTATTCT TGACTTTTTTAGAGAATATACATCTTAAGACTGTATTAGTTCTCAGAGCAAGGCATCATCTACTCCCCTGCACCTGAGAGTCTGGCCCCA GATTCCAGATGTGCGGACAGCCCATGACCGAGGTGCACACAGTGCCCTCTTGAATAGGAAGGTCAGCCAGTGAGGCGGCAGCATAACTTG CAGGATGGACTTATATCTTACCATCTCTTCCTGCTACCAAAATAAAAAAATAAATTGAAAGACAAGACCCACCAGTCTAGTTTTGTAGAC CTGTGAAATGTGTCTTTATTTCTTGGCATTAGAAGAAAGATATTTTTAATCCATATCGTGGTTTTAGAGTTGAAGTGAATTGATACCCAA TTTTCCATCTTAGATCTCCTTTATCAAAAAAAAAAGCATTTTTTTTCTCCTAACGTGTCTCCCAAAATGTAAATACTATAGGCAAAAAGA GTACCCTGTAAAATTCTCACACTGGAGCACCTCTTCAAAAGTCACAGATAACTCAATGAGGAAGTGCTGGTACTGCACTCACAGGACATG AGACCTATGAAGCTTTCGTGTTTTGAAAGCATCCTTCTGTGTGAGGGGGACTGCCTCCCTTAGTAAAGTAAACCTCTCAGAACTTCTTTT TAAAATAAAAACAGACAAGATGCAGTTACTAAGCTGCAAGTTTTCATTGGCAAACCTAGCTGAATCCGTTTTAAAATACTTAGCACTCGG ACACAATTCTCAAACTCAGGAAGAAGGAACAGGGTTGGTTTGGGTTTACTATAAAGGTTGCCTCACATAAACAACTGACTCCTTTTAGCG TTTTTTTTCTTTTTGTAAAAACTTTACACAAAATAGGGTTTTAAATTCTTTTTGCTTGTTTTGGACTTGGTGTATTTTTGTCAAGTTTAT ATTGATTGGCAACGCAGAGACTCCTTGAGGGCAGGGACTGTGGCCTTTGATTCACTTATGCTACAGTCTAGTATCACTACAGTGCTGAGT AAAAGACACAGCCCCTGCCCTCTTGGAGATCATATTGTTTATATTTGAAATCTCAGTTGCTAAGAGTATGTATGTGTGAGTAAGAAAGAC GTGAAGTCCTATGGGCAGCTGGGTATATGGAGAATTACGTGTGTCCTGTCTTTAAAACGTCAGCCTCTATTAAGGGGTACAGAACACCCC AAGATCACTAAAACTTGGAATGTGTTGGAGGCAGAAAGTATCTCTCTCATTGCCTAGTGTTGTTGTTTTTTTGTTTTTTGTTTTTTGTTT TTTTTACTGACCTGGAATTCTTTTAATTGTAATAAATATCTTCTGTCACAAATAAATGCCACAAATAAATGAAATTGCCATTCCTAAGCT GAGCACCTGTCTGTGAAGGACCTTGGTGTCCTGACTGGACAGAGCATTCATAGCTCCAAGAGAATCATGACAAGATATGCAAAGCAGGGA TAATAAGGAGAAAGCCCTTCCCTTTCGAGAAGCCCTTCCCTTTCACAGCCCTTCCCTGCGATTCTGCAGTGAAAAGTGATGCCCAGAGAT CCACACACAGAACCCTTCTAACCAGCCAGGTCAAGACTTATCATCTTATCTCCTCTGGCAGGTCCCCTGTAATCAAAAGAGAGGAAGTGT CTATCTAAACAAGACCCTTTTGGGTCCTTAGATTCATGGCAAAAATCATCATGGCCCCCATCAGAAAAGAAAATCAGCAATAAACCAAGC CAAGCAACTAAAATGTATAATGTGGACCTGACTCATGTTGGGAGGCAGAATTCAGACACTCACAGATCAATCTTGCAAGTTTTCTCTTCT TTAAGTTGAGCTGCTCAACTTTATGAACTGTGAAATTTACTTACATTCTTTCAACCCACATATATCATTGCAGTTTATGAAGTTGCAGTG AACTGCCCATTCAGCTAAATTGCAGTGTTTATTCTTGTCTCATGTCGAAATACAACAATCTTATGGGAAATATTATGACAGTCCGTTCCA ACTGTTCTCAGACACATGCATAAACAGTCTCTGCTCACATTCCACAGCCACCTGCATGTTATCCATACAGCTCCCTGAGAAGTCCAGGGA TGGGAGGTGGGGTGTGGAAGGATGGAGGGTCCTTCATTTTCTAAACACTTTGTATAAGTCACTACTCATCGTGCCTAGCAAGTATAAGAT TAACATTTTGAATAACAAACTGGAAAACAAATAATCCTTCAAAGAACCTAGCGAACTGTTCAAAGGAAATTTTAATTTCAGTCTACCAGA AAAGTTAAATCTGTTGTTGGACGTAGGGGGCTTTCAGAAACATGCCTCTTATATCAATTTCCACTATCTTTCAAGTTACCTAAAGGCACC AGGCTGCTTGAGCAAGAAGAATAAAAGGCCTAGAGTGCAAATTATGTGAAGTAGAGTTTTTAGATTGTGGGATTGTAATAATACGGGATT CTCATGGTTACATCATGTTAAATCACACTGTTCAGTCTTTAAAACTTGGTGTTTTAAAATTTGTCTCATTGTGATAGCCAGAAACAAGGA ATAAACGTGATTTCAGTTTAAACTATATACAAATATCTTCTGTAATTTTGCTGCTCTAATTTTTAGGCTATAAATTTTGTAATAGAGCTT ATCAGATCGCAAATTTCCTTTGTTTACAATCTCATGTAGTAGGGCTCAGATAATTTCTTAGCTATAAACCTTTTCTCCCACTCTCATATT GTTTCATTTAAAATATTTAAGCTAAGCCTAAAAATTGAAATCAGTTAAGAATTTGGAGAGTTTATCTTAAATGGAAATGGTGTATTCTTT TCAAAGAATTTTGTAACCATCTTTACAGTTTCTTTGCTTGGAAAACTTGGGTTGTTAACTACCAGTTAACAATGGCATTACTTTCCAAAA CGTTATCTAATGGGCCCAATGTGTACCTCAAGATAAACACAGTATGTTATGTCTAAAAATTTCCTTGTCTGTTGATTTAAATGGTTCTGA >5302_5302_6_AP3S2-GAREM_AP3S2_chr15_90414707_ENST00000560940_GAREM_chr18_29868166_ENST00000399218_length(amino acids)=867AA_BP=123 MREPWLAKMIQAILVFNNHGKPRLVRFYQRFPEEIQQQIVRETFHLVLKRDDNICNFLEGGSLIGGSDYKLIYRHYATLYFVFCVDSSES ELGILDLIQVFVETLDKCFENVCELDLIFHMDKVASGECNEDTEVYNITLCTGDELTLMGQAEILYAKTFKEKSRLNTIFKKIGKLNSIS KLGKGKMPCLICMNHRTNESISLPFQCKGRFSTRSPLELQMQEGEHTIRNIVEKTRLPVNVTVPSPPPRNPYDLHFIREGHRYKFVNIQT KTVVVCCVLRNNKILPMHFPLHLTVPKFSLPEHLVKGESWPETLVHHWLGICQEQFDIDEYSRAVRDVKTDWNEECKSPKKGRCSGHNHV PNSLSYARDELTQSFHRLSVCVYGNNLHGNSEVNLHGCRDLGGDWAPFPHDILPYQDSGDSGSDYLFPEASEESAGIPGKSELPYEELWL EEGKPSHQPLTRSLSEKNRCDQFRGSVRSKCATSPLPIPGTLGAAVKSSDTALPPPPVPPKSEAVREECRLLNAPPVPPRSAKPLSTSPS IPPRTVKPARQQTRSPSPTLSYYSSGLHNIVTKTDTNPSESTPVSCYPCNRVKTDSVDLKSPFGSPSAEAVSSRLSWPNHYSGASESQTR SDFLLDPSRSYSYPRQKTPGTPKRNCPAPFDFDGCELLASPTSPVTAEFSSSVSGCPKSASYSLESTDVKSLAAGVTKQSTSCPALPPRA PKLVEEKVASETSPLPLKIDGAEEDPKSGSPDLSEDQYFVKKGMQDIFSASYPFSSPLHLQLAPRSCGDGSPWQPPADLSGLSIEEVSKS -------------------------------------------------------------- |
Top |
Fusion Gene PPI Analysis for AP3S2-GAREM |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
Related Drugs for AP3S2-GAREM |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
Related Diseases for AP3S2-GAREM |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | AP3S2 | C0011860 | Diabetes Mellitus, Non-Insulin-Dependent | 1 | CTD_human |
Copyright 2021-Present -The University of Texas Health Science Center at Houston (UTHealth)
Web File Viewing | Emergency Information |Campus Carry|Site Policies