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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ADAM10-TERB2 (FusionGDB2 ID:HG102TG145645)

Fusion Gene Summary for ADAM10-TERB2

check button Fusion gene summary
Fusion gene informationFusion gene name: ADAM10-TERB2
Fusion gene ID: hg102tg145645
HgeneTgene
Gene symbol

ADAM10

TERB2

Gene ID

102

145645

Gene nameADAM metallopeptidase domain 10telomere repeat binding bouquet formation protein 2
SynonymsAD10|AD18|CD156c|CDw156|HsT18717|MADM|RAK|kuzC15orf43
Cytomap('ADAM10','ADAM10')('C15orf43','TERB2')

15q21.3

15q21.1

Type of geneprotein-codingprotein-coding
Descriptiondisintegrin and metalloproteinase domain-containing protein 10a disintegrin and metalloprotease domain 10kuzbanian protein homologmammalian disintegrin-metalloproteasetelomere repeats-binding bouquet formation protein 2
Modification date2020032920200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000558733, ENST00000260408, 
ENST00000396140, ENST00000402627, 
ENST00000561288, 
Fusion gene scores* DoF score14 X 12 X 7=11764 X 3 X 4=48
# samples 174
** MAII scorelog2(17/1176*10)=-2.79028140869866
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(4/48*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ADAM10 [Title/Abstract] AND TERB2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointADAM10(59009776)-C15orf43(45266065), # samples:2
ADAM10(59009776)-TERB2(45266065), # samples:1
Anticipated loss of major functional domain due to fusion event.ADAM10-C15orf43 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ADAM10-C15orf43 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneADAM10

GO:0006509

membrane protein ectodomain proteolysis

12714508|17557115|18355449|18419754|18676862|19114711

HgeneADAM10

GO:0007162

negative regulation of cell adhesion

12714508

HgeneADAM10

GO:0034612

response to tumor necrosis factor

11831872

HgeneADAM10

GO:0051089

constitutive protein ectodomain proteolysis

12714508


check buttonFusion gene breakpoints across ADAM10 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across TERB2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BLCATCGA-4Z-AA7R-01AADAM10chr15

59009776

-C15orf43chr15

45266065

+
ChimerDB4BLCATCGA-4Z-AA7RADAM10chr15

59009776

-C15orf43chr15

45266065

+
ChimerDB4BLCATCGA-4Z-AA7R-01AADAM10chr15

59009776

-TERB2chr15

45266065

+


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Fusion Gene ORF analysis for ADAM10-TERB2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000558733ENST00000340827ADAM10chr15

59009776

-C15orf43chr15

45266065

+
In-frameENST00000260408ENST00000340827ADAM10chr15

59009776

-C15orf43chr15

45266065

+
intron-3CDSENST00000396140ENST00000340827ADAM10chr15

59009776

-C15orf43chr15

45266065

+
intron-3CDSENST00000402627ENST00000340827ADAM10chr15

59009776

-C15orf43chr15

45266065

+
intron-3CDSENST00000561288ENST00000340827ADAM10chr15

59009776

-C15orf43chr15

45266065

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000260408ADAM10chr1559009776-ENST00000340827C15orf43chr1545266065+1480650444878144

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000260408ENST00000340827ADAM10chr1559009776-C15orf43chr1545266065+0.0036319930.99636805

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Fusion Genomic Features for ADAM10-TERB2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
ADAM10chr1559009775-C15orf43chr1545266064+3.42E-141
ADAM10chr1559009775-C15orf43chr1545266064+3.42E-141
ADAM10chr1559009775-C15orf43chr1545266064+3.42E-141
ADAM10chr1559009775-C15orf43chr1545266064+3.42E-141

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for ADAM10-TERB2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:59009776/:45266065)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneADAM10chr15:59009776chr15:45266065ENST00000260408-216555_67368749.0Compositional biasCys-rich
HgeneADAM10chr15:59009776chr15:45266065ENST00000260408-216220_45668749.0DomainPeptidase M12B
HgeneADAM10chr15:59009776chr15:45266065ENST00000260408-216457_55168749.0DomainDisintegrin
HgeneADAM10chr15:59009776chr15:45266065ENST00000260408-216171_17868749.0MotifCysteine switch
HgeneADAM10chr15:59009776chr15:45266065ENST00000260408-216708_71568749.0MotifSH3-binding
HgeneADAM10chr15:59009776chr15:45266065ENST00000260408-216722_72868749.0MotifSH3-binding
HgeneADAM10chr15:59009776chr15:45266065ENST00000260408-21620_67268749.0Topological domainExtracellular
HgeneADAM10chr15:59009776chr15:45266065ENST00000260408-216694_74868749.0Topological domainCytoplasmic
HgeneADAM10chr15:59009776chr15:45266065ENST00000260408-216673_69368749.0TransmembraneHelical


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Fusion Gene Sequence for ADAM10-TERB2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>1942_1942_1_ADAM10-C15orf43_ADAM10_chr15_59009776_ENST00000260408_C15orf43_chr15_45266065_ENST00000340827_length(transcript)=1480nt_BP=650nt
GCGGCGGCAGGCCTAGCAGCACGGGAACCGTCCCCCGCGCGCATGCGCGCGCCCCTGAAGCGCCTGGGGGACGGGTAGGGGCGGGAGGTA
GGGGCGCGGCTCCGCGTGCCAGTTGGGTGCCCGCGCGTCACGTGGTGAGGAAGGAGGCGGAGGTCTGAGTTTCGAAGGAGGGGGGGAGAG
AAGAGGGAACGAGCAAGGGAAGGAAAGCGGGGAAAGGAGGAAGGAAACGAACGAGGGGGAGGGAGGTCCCTGTTTTGGAGGAGCTAGGAG
CGTTGCCGGCCCCTGAAGTGGAGCGAGAGGGAGGTGCTTCGCCGTTTCTCCTGCCAGGGGAGGTCCCGGCTTCCCGTGGAGGCTCCGGAC
CAAGCCCCTTCAGCTTCTCCCTCCGGATCGATGTGCTGCTGTTAACCCGTGAGGAGGCGGCGGCGGCGGCAGCGGCAGCGGAAGATGGTG
TTGCTGAGAGTGTTAATTCTGCTCCTCTCCTGGGCGGCGGGGATGGGAGGTCAGTATGGGAATCCTTTAAATAAATATATCAGACATTAT
GAAGGATTATCTTACAATGTGGATTCATTACACCAAAAACACCAGCGTGCCAAAAGAGCAGTCTCACATGAAGACCAATTTTTACGTCTA
GATTTCCATGCCCATGGAAGCCCAGAAAAGCATTTTATAAGAACTCCAGTTGTAGAAAAGCAGATGTACTTCCCTCTACAGAATTACCCA
GTTAACAACATGGTAACAGGTTATATATCAATTGATGCCATGAAGAAATTCCTTGGGGAGCTACATGACTTCATTCCTGGAACCTCAGGA
TATTTGGCATATCATGTTCAAAATGAAATTAATATGTCTGCTATAAAAAACAAATTGAAGAGGAAATAGTAAATTAAATTGTAAATACCT
TGGCATTTATTTTCTATAAAATATTATACAGATGTGCATATCATAAAATGCTCCCTTTTGGTACTGGGGGATAGTGAAATGGGAAATAAT
TTTTCTGTTTCTCAAAGTATATCTTTAGGAAATACAGAATCATTTTGGTTCTGTGTTTTGACATTTTTCCCCTAGCTTTTAACAACATGT
TCAAATATTCTCAATGCACAGTTGTTAATGAGTAATTGCCGTTAAAATATATTTCATAAGAAGTCTCAATCTCAAACTCTCCATCTCTCA
ATCCTCCTCCTCCTCCTCTTTCTTGCTTTCTCTTTTCCCTCTCTCTTTCTCTCCTCCCCTTCTCTCTTTCTGTCTTTCAAATGTTCTTTT
GGCTTTAACATTCTATTAATTATATTTTTTCTAGATTGAATACTGTGAATGCTAAGTTTTATTAATCTGGTCATCTTATTTTGATTTTAA
AAATTAGGATGCTAGTTGCATTCTGAATTACTGTTTCTGGTTTGAAACATGGAGAAAAACATTTTAATAATTCATATTTCATGTTGGATG

>1942_1942_1_ADAM10-C15orf43_ADAM10_chr15_59009776_ENST00000260408_C15orf43_chr15_45266065_ENST00000340827_length(amino acids)=144AA_BP=68
MVLLRVLILLLSWAAGMGGQYGNPLNKYIRHYEGLSYNVDSLHQKHQRAKRAVSHEDQFLRLDFHAHGSPEKHFIRTPVVEKQMYFPLQN

--------------------------------------------------------------

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Fusion Gene PPI Analysis for ADAM10-TERB2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneADAM10chr15:59009776chr15:45266065ENST00000260408-216734_74868.66666666666667749.0AP2A1%2C AP2A2 and AP2M1


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ADAM10-TERB2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ADAM10-TERB2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneADAM10C3810041ALZHEIMER DISEASE 182CTD_human;UNIPROT
HgeneADAM10C0002395Alzheimer's Disease1CTD_human
HgeneADAM10C0006142Malignant neoplasm of breast1CTD_human
HgeneADAM10C0011265Presenile dementia1CTD_human
HgeneADAM10C0276496Familial Alzheimer Disease (FAD)1CTD_human
HgeneADAM10C0406811Reticulate acropigmentation of Kitamura1CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
HgeneADAM10C0494463Alzheimer Disease, Late Onset1CTD_human
HgeneADAM10C0546126Acute Confusional Senile Dementia1CTD_human
HgeneADAM10C0678222Breast Carcinoma1CTD_human
HgeneADAM10C0750900Alzheimer's Disease, Focal Onset1CTD_human
HgeneADAM10C0750901Alzheimer Disease, Early Onset1CTD_human
HgeneADAM10C1257931Mammary Neoplasms, Human1CTD_human
HgeneADAM10C1458155Mammary Neoplasms1CTD_human
HgeneADAM10C4704874Mammary Carcinoma, Human1CTD_human