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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:CDKN2B-DGKD (FusionGDB2 ID:HG1030TG8527)

Fusion Gene Summary for CDKN2B-DGKD

check button Fusion gene summary
Fusion gene informationFusion gene name: CDKN2B-DGKD
Fusion gene ID: hg1030tg8527
HgeneTgene
Gene symbol

CDKN2B

DGKD

Gene ID

1030

8527

Gene namecyclin dependent kinase inhibitor 2Bdiacylglycerol kinase delta
SynonymsCDK4I|INK4B|MTS2|P15|TP15|p15INK4bDGK-delta|DGKdelta|dgkd-2
Cytomap('CDKN2B')('DGKD')

9p21.3

2q37.1

Type of geneprotein-codingprotein-coding
Descriptioncyclin-dependent kinase 4 inhibitor BCDK inhibitory proteinCDK4B inhibitorMTS-2cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)cyclin-dependent kinases 4 and 6 binding proteinmultiple tumor suppressor 2p14-INK4bp14_CDK inhibitorp14_INK4Bdiacylglycerol kinase deltaDAG kinase deltadiacylglycerol kinase, delta 130kDadiglyceride kinase delta
Modification date2020032220200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000276925, ENST00000380142, 
ENST00000539462, 
Fusion gene scores* DoF score2 X 2 X 2=83 X 3 X 3=27
# samples 23
** MAII scorelog2(2/8*10)=1.32192809488736log2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: CDKN2B [Title/Abstract] AND DGKD [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCDKN2B(22008797)-DGKD(234296903), # samples:1
Anticipated loss of major functional domain due to fusion event.CDKN2B-DGKD seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
CDKN2B-DGKD seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
CDKN2B-DGKD seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
CDKN2B-DGKD seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
CDKN2B-DGKD seems lost the major protein functional domain in Hgene partner, which is a tumor suppressor due to the frame-shifted ORF.
CDKN2B-DGKD seems lost the major protein functional domain in Tgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
CDKN2B-DGKD seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCDKN2B

GO:0000079

regulation of cyclin-dependent protein serine/threonine kinase activity

8078588

HgeneCDKN2B

GO:0042326

negative regulation of phosphorylation

8078588

TgeneDGKD

GO:0010033

response to organic substance

12200442


check buttonFusion gene breakpoints across CDKN2B (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across DGKD (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4GBMTCGA-06-0155-01BCDKN2Bchr9

22008797

-DGKDchr2

234296903

+


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Fusion Gene ORF analysis for CDKN2B-DGKD

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000276925ENST00000489613CDKN2Bchr9

22008797

-DGKDchr2

234296903

+
Frame-shiftENST00000276925ENST00000409813CDKN2Bchr9

22008797

-DGKDchr2

234296903

+
In-frameENST00000276925ENST00000264057CDKN2Bchr9

22008797

-DGKDchr2

234296903

+
intron-3CDSENST00000380142ENST00000264057CDKN2Bchr9

22008797

-DGKDchr2

234296903

+
intron-3CDSENST00000380142ENST00000409813CDKN2Bchr9

22008797

-DGKDchr2

234296903

+
intron-3CDSENST00000539462ENST00000264057CDKN2Bchr9

22008797

-DGKDchr2

234296903

+
intron-3CDSENST00000539462ENST00000409813CDKN2Bchr9

22008797

-DGKDchr2

234296903

+
intron-3UTRENST00000380142ENST00000489613CDKN2Bchr9

22008797

-DGKDchr2

234296903

+
intron-3UTRENST00000539462ENST00000489613CDKN2Bchr9

22008797

-DGKDchr2

234296903

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000276925CDKN2Bchr922008797-ENST00000264057DGKDchr2234296903+669556618540541289

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000276925ENST00000264057CDKN2Bchr922008797-DGKDchr2234296903+0.0017308610.9982691

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Fusion Genomic Features for CDKN2B-DGKD


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
CDKN2Bchr922008796-DGKDchr2234296902+0.0007914370.9992086
CDKN2Bchr922008796-DGKDchr2234296902+0.0007914370.9992086

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for CDKN2B-DGKD


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr9:22008797/chr2:234296903)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCDKN2Bchr9:22008797chr2:234296903ENST00000276925-1213_3952139.0RepeatNote=ANK 1%3B truncated
TgeneDGKDchr9:22008797chr2:234296903ENST000004098130298_3601171.0Compositional biasNote=Pro-rich
TgeneDGKDchr9:22008797chr2:234296903ENST000002640570301145_1208521215.0DomainSAM
TgeneDGKDchr9:22008797chr2:234296903ENST00000264057030317_451521215.0DomainDAGKc
TgeneDGKDchr9:22008797chr2:234296903ENST0000026405703053_146521215.0DomainPH
TgeneDGKDchr9:22008797chr2:234296903ENST000004098130291145_120801171.0DomainSAM
TgeneDGKDchr9:22008797chr2:234296903ENST00000409813029317_45101171.0DomainDAGKc
TgeneDGKDchr9:22008797chr2:234296903ENST0000040981302953_14601171.0DomainPH
TgeneDGKDchr9:22008797chr2:234296903ENST00000264057030163_213521215.0Zinc fingerPhorbol-ester/DAG-type 1
TgeneDGKDchr9:22008797chr2:234296903ENST00000264057030235_286521215.0Zinc fingerPhorbol-ester/DAG-type 2
TgeneDGKDchr9:22008797chr2:234296903ENST00000409813029163_21301171.0Zinc fingerPhorbol-ester/DAG-type 1
TgeneDGKDchr9:22008797chr2:234296903ENST00000409813029235_28601171.0Zinc fingerPhorbol-ester/DAG-type 2

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCDKN2Bchr9:22008797chr2:234296903ENST00000276925-12112_13852139.0RepeatNote=ANK 4
HgeneCDKN2Bchr9:22008797chr2:234296903ENST00000276925-1246_7452139.0RepeatNote=ANK 2
HgeneCDKN2Bchr9:22008797chr2:234296903ENST00000276925-1279_10852139.0RepeatNote=ANK 3
HgeneCDKN2Bchr9:22008797chr2:234296903ENST00000380142-12112_138079.0RepeatNote=ANK 4
HgeneCDKN2Bchr9:22008797chr2:234296903ENST00000380142-1213_39079.0RepeatNote=ANK 1%3B truncated
HgeneCDKN2Bchr9:22008797chr2:234296903ENST00000380142-1246_74079.0RepeatNote=ANK 2
HgeneCDKN2Bchr9:22008797chr2:234296903ENST00000380142-1279_108079.0RepeatNote=ANK 3
HgeneCDKN2Bchr9:22008797chr2:234296903ENST00000539462-11112_138079.0RepeatNote=ANK 4
HgeneCDKN2Bchr9:22008797chr2:234296903ENST00000539462-1113_39079.0RepeatNote=ANK 1%3B truncated
HgeneCDKN2Bchr9:22008797chr2:234296903ENST00000539462-1146_74079.0RepeatNote=ANK 2
HgeneCDKN2Bchr9:22008797chr2:234296903ENST00000539462-1179_108079.0RepeatNote=ANK 3
TgeneDGKDchr9:22008797chr2:234296903ENST000002640570308_36521215.0Compositional biasNote=Pro-rich


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Fusion Gene Sequence for CDKN2B-DGKD


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>15416_15416_1_CDKN2B-DGKD_CDKN2B_chr9_22008797_ENST00000276925_DGKD_chr2_234296903_ENST00000264057_length(transcript)=6695nt_BP=566nt
GGGAGACGCCGGCCCCTTGGCCCAGCTGAAAACGGAATTCTTTGCCGGCTGGCTCCCCACTCTGCCAGAGCGAGGCGGGGCAGTGAGGAC
TCCGCGACGCGTCCGCACCCTGCGGCCAGAGCGGCTTTGAGCTCGGCTGCGTCCGCGCTAGGCGCTTTTTCCCAGAAGCAATCCAGGCGC
GCCCGCTGGTTCTTGAGCGCCAGGAAAAGCCCGGAGCTAACGACCGGCCGCTCGGCCACTGCACGGGGCCCCAAGCCGCAGAAGGACGAC
GGGAGGGTAATGAAGCTGAGCCCAGGTCTCCTAGGAAGGAGAGAGTGCGCCGGAGCAGCGTGGGAAAGAAGGGAAGAGTGTCGTTAAGTT
TACGGCCAACGGTGGATTATCCGGGCCGCTGCGCGTCTGGGGGCTGCGGAATGCGCGAGGAGAACAAGGGCATGCCCAGTGGGGGCGGCA
GCGATGAGGGTCTGGCCAGCGCCGCGGCGCGGGGACTAGTGGAGAAGGTGCGACAGCTCCTGGAAGCCGGCGCGGATCCCAACGGAGTCA
ACCGTTTCGGGAGGCGCGCGATCCAGACCATCATCAAAGAGGGGATGCTGACCAAACAGAACAATTCATTCCAGCGATCAAAAAGGAGAT
ACTTTAAGCTTCGAGGGCGAACGCTTTACTATGCCAAAACGGCAAAGTCAATCATATTTGATGAGGTGGATCTGACAGATGCCAGCGTAG
CTGAATCCAGTACCAAAAACGTCAACAACAGTTTTACGGTCATAACTCCATGCAGGAAGCTCATCTTGTGTGCTGATAACAGAAAAGAAA
TGGAAGATTGGATTGCAGCATTAAAGACTGTGCAGAACAGGGAGCACTTTGAGCCCACCCAGTACAGCATGGACCACTTCTCAGGGATGC
ACAATTGGTACGCCTGTTCCCACGCGAGGCCGACCTACTGCAATGTGTGCCGTGAGGCTCTGTCTGGGGTCACGTCGCACGGGCTGTCCT
GCGAGGTGTGCAAATTTAAGGCCCACAAGCGCTGTGCTGTGCGTGCAACCAATAACTGCAAGTGGACCACACTGGCCTCGATCGGGAAGG
ACATCATTGAAGATGCAGATGGGATTGCAATGCCCCACCAGTGGTTGGAAGGAAACCTACCTGTGAGCGCCAAGTGCACTGTGTGCGACA
AGACCTGTGGCAGTGTGCTGCGCCTGCAGGACTGGCGCTGCCTCTGGTGCAAGGCCATGGTTCACACATCGTGTAAAGAATCCTTGCTGA
CCAAGTGCCCACTTGGCCTGTGCAAAGTGTCAGTCATCCCACCCACGGCTCTCAACAGCATCGACTCCGATGGGTTCTGGAAGGCCAGCT
GTCCTCCTTCTTGCACAAGCCCACTGTTGGTCTTCGTCAATTCAAAAAGTGGGGACAACCAGGGTGTGAAGTTCCTCAGAAGATTCAAAC
AGCTACTAAACCCCGCCCAGGTCTTCGACCTCATGAACGGAGGCCCACACCTCGGCTTACGGTTATTCCAGAAGTTTGACACATTCCGGA
TTCTGGTTTGTGGCGGGGATGGAAGTGTTGGCTGGGTCCTCTCCGAAATCGACAGCCTCAACCTTCATAAACAGTGTCAGCTGGGAGTGC
TGCCGCTCGGCACAGGGAACGACTTGGCCCGAGTACTGGGCTGGGGCTCAGCCTGCGATGACGACACCCAGCTCCCCCAGATCTTGGAGA
AGTTGGAGAGAGCCAGCACCAAGATGCTGGACAGGTGGAGCGTCATGGCATACGAGGCCAAGCTCCCCCGGCAGGCCTCCTCCTCTACCG
TCACCGAAGACTTCAGCGAGGATTCCGAGGTACAGCAGATTCTCTTCTATGAAGACTCGGTTGCAGCCCACCTTTCTAAAATCCTCACCT
CGGACCAGCACTCGGTGGTCATCTCCTCGGCCAAAGTGCTCTGTGAGACGGTGAAGGACTTCGTGGCACGGGTGGGGAAGGCCTATGAGA
AGACGACCGAGAGCTCGGAGGAGTCAGAGGTCATGGCCAAGAAGTGCTCTGTCCTGAAAGAGAAGCTGGATTCCCTTCTCAAGACCTTGG
ACGATGAGTCCCAGGCCTCGTCCTCTCTGCCCAACCCGCCCCCCACCATTGCCGAGGAGGCTGAAGATGGAGATGGGTCGGGCAGCATCT
GCGGTTCCACCGGAGACCGCTTGGTGGCATCAGCTTGCCCGGCCCGGCCGCAGATATTCCGGCCTCGAGAACAGCTCATGCTGAGAGCCA
ACAGCCTGAAGAAAGCAATTCGTCAGATCATAGAACACACAGAAAAAGCTGTCGATGAGCAGAATGCCCAGACCCAGGAGCAGGAGGGCT
TCGTCCTGGGCCTCTCTGAGTCAGAGGAGAAGATGGACCACAGAGTGTGCCCACCACTGTCCCACAGCGAGAGCTTCGGGGTCCCCAAGG
GGAGGAGCCAGCGCAAAGTGTCGAAATCTCCGTGTGAAAAGCTGATCAGCAAAGGGAGTCTGTCCCTAGGCAGTTCTGCTTCCCTTCCGC
CCCAGCCGGGAAGCCGGGACGGCCTGCCTGCGCTCAACACCAAGATCCTGTACCCAAATGTCCGGGCTGGAATGTCTGGTTCCTTACCCG
GTGGCTCAGTCATCAGTCGCCTGTTAATTAATGCTGATCCCTTCAACTCTGAACCAGAAACCCTAGAGTATTACACGGAGAAATGTGTCA
TGAACAACTATTTTGGCATTGGCCTGGATGCGAAGATATCCCTGGACTTTAACAACAAGCGCGATGAGCACCCAGAGAAGTGCAGGAGCC
GAACCAAGAACATGATGTGGTATGGAGTTCTTGGAACCAAAGAGTTGCTGCACAGAACCTACAAGAACCTGGAGCAAAAGGTCTTGCTGG
AGTGTGACGGGCGACCCATCCCACTCCCCAGTCTTCAGGGAATTGCTGTCCTTAACATTCCCAGCTATGCCGGAGGAACCAACTTCTGGG
GGGGTACCAAGGAAGATGATACTTTCGCAGCTCCATCATTCGATGACAAGATTCTGGAGGTGGTCGCCGTGTTCGGCAGCATGCAGATGG
CCGTCTCTCGAGTCATCAGGCTACAGCATCATCGGATCGCCCAGTGTCGCACGGTGAAGATCTCCATCCTTGGGGATGAGGGCGTGCCTG
TGCAGGTGGACGGAGAGGCCTGGGTCCAGCCGCCAGGGTACATTCGGATTGTCCACAAGAACCGGGCACAGACACTGACCAGAGACAGGG
CATTTGAGAGCACCCTGAAGTCCTGGGAAGACAAGCAGAAGTGCGAGCTGCCCCGCCCTCCATCCTGTTCCCTGCACCCGGAGATGCTGT
CCGAGGAGGAGGCCACCCAGATGGACCAGTTTGGGCAGGCAGCAGGGGTCCTCATTCACAGTATCCGAGAAATAGCTCAGTCTCACCGGG
ACATGGAGCAGGAACTGGCCCACGCCGTCAATGCCAGCTCCAAGTCCATGGACCGTGTGTATGGCAAGCCCAGAACCACAGAGGGGCTCA
ACTGCAGCTTCGTCCTGGAAATGGTGAATAACTTCAGAGCTCTGCGCAGTGAGACGGAGCTGCTGCTGTCTGGGAAGATGGCCCTGCAGC
TGGATCCGCCTCAGAAGGAGCAGCTGGGGAGTGCTCTTGCCGAGATGGACCGACAGCTCAGGAGGCTGGCAGACACCCCGTGGCTCTGCC
AGTCCGCAGAGCCCGGCGACGAAGAGAGTGTGATGCTGGATCTTGCCAAGCGCAGTCGCAGTGGTAAATTCCGCCTCGTGACCAAGTTTA
AAAAGGAGAAAAACAACAAGAACAAAGAAGCTCACAGTAGCCTGGGAGCCCCGGTTCACCTCTGGGGGACAGAGGAGGTTGCTGCCTGGC
TGGAGCACCTCAGTCTCTGTGAGTATAAGGACATCTTCACACGGCACGACATCCGGGGCTCTGAGCTCCTGCACCTGGAGCGGAGGGACC
TCAAGGACCTGGGCGTGACCAAGGTGGGCCACATGAAGAGGATCCTGTGTGGCATCAAGGAGCTGAGCCGCAGCGCCCCCGCCGTCGAGG
CCTAGCCTCTGTCCTCTCAGCCTGTGGCCTCCACATCCCCGCCGCCGAGGCCTAGCCTCCGCCCTCTCAGCCTGTGGCCTCTGCGCCTCC
TGCCACTGAGGCCCTGGGCAGATGCTGCAGCCCGCCCCCTTCTCATGGTGCTACTTCCTCTGTCAGCTACAGAAAGCCTCCGTGACACCG
TCCACCAGAGCTCTGGGGTCTCGAACATAACAACACAGCTACCTTTGAAACAACACTTTCTCCAGCTCAGAGTCACCTGGGGCACATGTG
TCACGGCCACTCAGCTCTCGCCCGCCTGTGCTGTGGGCCAGGGAATCCAGCGGCGTCTGGCCTCCTGGGCACTGCTTGCCTGGCCTCGTG
CTTGGATTGTCCCGGGGGCTCCTCTCCGTGTGTCCTTCTGTGGCCGCACCGTGTGGCTCCGCCTCCTGGCCCCCAGCCAGTTCTCAGAAA
CGTGGCTGGGGCCCAGCACAGCAGCCTGCAAGGGCCCCTGTTTGTTGATGCAGCTTTTGTTGAACAAAAATCGTGCTCTTTCCTGGTTTG
AAAGTAGCATGGATGTTTCCAGTCTTGTTGATTGTAATTTGACGTGAAGAGAAAAAAAAATTCCTCCTGCGTGAGCCAAGGCAGCGGGTG
CTGTTTCCCAGGCGGGGAGCCCCTCCCTGGGTGTCACAGGGCCTGTGCTCCTCCCTCCTCCATCCTCTCTCCTCCCGCTCCTCCCTCCCC
CCACTGTGGGCTGGGGACGCCTGCCCTTCTGTCTCCGGACGCTCTAGGCGAGTTCAGCTTGGGGTGTGAGTGAGACAGCTTGCCAGCTGC
ATCCCTGCAGACAGAGGATGTGTGTCCACATGAGTGTTTCTGTGTGGGAAATGCTTCCTGGCTCTGGGAAACTTTTTCTGCCCATTCTGT
GGTTCCCAGGGAGCGTGGCCCTGGTGGGCCAGGGGTGGTTTGACCTCTTCAGCCCGTCCGGTGGCCTGGAGGCCGGAGGCTCTCCTGAGT
GTCTGCCCCTGCAGTGGCTTCTTGTCGCCTGCTGCTGGGCGTGATGTCGCTGGAGGTGCTGGCAGGGACTCTGATTTGGTGGTCCGCGCT
GCCCCTGCCCTGCCTCTGTCCTGGCTCTGAACTAGTAGATGATGGTGCCAGAGGGCAGGGAGCTCGCCTGGGGAGAGGGCTGTGCCCCGT
AGGGACAGTGCCCAGGTGAAGGATGCCCCTGGTCCTCCAGGGCACTGACTTTGCCCTTTTTTCCCGTTGATAGTCATGGCTCAGAGGTGC
TTGTAAATGTCTTGGGAAGAGGTTTCTGTAACCCCTGCCCTGGTGTGAGGAGGAAATGGCTCTGGCCTGGCTGCCTGGCCGTGGCTTCTC
TTTGGCTCCCAAAGAGAAGGACAGTGTTGGGAGTATCTGCCGTGGCTTCTCTTTGGCTCCCAAAGAGAAGGACAGTGTTGGGAGTATCTG
CCGGCGCTGTCCAGGTCCTTTAGTCAGCGTCACTCCATCTGATGTGCAGAAGCTGGGCTGCACCTGCGGGGGTGGGCATAGACCGGGCTG
GGTCTGCAGCAGCCCCTGGTCCTGAGCAGGCGGCAGTGAACAGCACTGGCCCACCTCCCACTCACAGCCCCTCTGTCCCCTCTGCAGTGC
ACCCAGGTGGGCCCCTCTGCGTGCCTTTGGGTGCTCCCCTCTCGTGGTCGTTCTGGCCCGAGGCCCTTAGAGTATGGAGGCTGAGCCAGG
CCTTGGGTTTCCCCAGCACAGCCTCCTGTCGCTGCATGCGACGTGTTGGGATTTTTGGATGAAAGACTCTCCCACGCTCTGTTGGTGGAC
TTAGCTGCCTCACTGGAAGTGATGTGGGTGGAAGGTGGTTGTATGTTACCTTTTCCACCTCTCATTGTTTTCCCCAGAACATTGTAGATG
GGGGTTGGCAGAGGGAGAAATAAGCCAGCCACGGCAGTCGCTTGGTTTCCCAGGTGGAATGGGCTAACACAGGAGATGATGGGAACCTGT
CCCGCAGTCCCTGCATGACCATTGGCCCTGCTGGCCTGGCGATGTGGGCATCCTGGGGTTCTTAGGGTCCCAGAACAAGCCCCAGGCAAG
CTGGAACTTGGGTGGGGAGGGGACATGAGGAGGATAAACAGCTGACTGTGGCTTCAAGGACATCAGGGCCACCCCAAGTCCTCAGTGTCC
TACTCCTGGCAAGGAGTTGGGTTTGGATCAAAAGTGTTTAAAATTAATATGTTGTCAGTGATTAGAACAACACTGTTTACATAAAAACCA
TTTTTCTAATTCTAACAAGTTAGAATGTGAGGAAGGAATGAACATGAGTGTTTAGGAACCTGCCCTTTGGTGCTGGGCTGGCGTCCCGCA
CTGGGGTGTCCTCGCTGTCTGGGGGCTGCTCTGCTGCCCCGGCCCAGGTCCCCTTGTGGTGTTGCCAGACGGGCCTCATGGTCTGCTGTG
CAGAGAGAGGCAGGAAGGATCCCTGAAGAGTCTTGGAGAAAAGGTTCTGTGCCCTCAGGTGGGGCTTACCCCCTCGTATTTATAATCTTA
ATTTATATAGTGACCACCGTGGAAACAAACGCCTCTTGTATTGTCATGTACATAGTCCATACCTGAGTGCTGTACATAAGTTGTTCTGTG
TATAAATAAAACAAGCCTGTTTTTGATCTTCCATC

>15416_15416_1_CDKN2B-DGKD_CDKN2B_chr9_22008797_ENST00000276925_DGKD_chr2_234296903_ENST00000264057_length(amino acids)=1289AA_BP=126
MVLERQEKPGANDRPLGHCTGPQAAEGRREGNEAEPRSPRKERVRRSSVGKKGRVSLSLRPTVDYPGRCASGGCGMREENKGMPSGGGSD
EGLASAAARGLVEKVRQLLEAGADPNGVNRFGRRAIQTIIKEGMLTKQNNSFQRSKRRYFKLRGRTLYYAKTAKSIIFDEVDLTDASVAE
SSTKNVNNSFTVITPCRKLILCADNRKEMEDWIAALKTVQNREHFEPTQYSMDHFSGMHNWYACSHARPTYCNVCREALSGVTSHGLSCE
VCKFKAHKRCAVRATNNCKWTTLASIGKDIIEDADGIAMPHQWLEGNLPVSAKCTVCDKTCGSVLRLQDWRCLWCKAMVHTSCKESLLTK
CPLGLCKVSVIPPTALNSIDSDGFWKASCPPSCTSPLLVFVNSKSGDNQGVKFLRRFKQLLNPAQVFDLMNGGPHLGLRLFQKFDTFRIL
VCGGDGSVGWVLSEIDSLNLHKQCQLGVLPLGTGNDLARVLGWGSACDDDTQLPQILEKLERASTKMLDRWSVMAYEAKLPRQASSSTVT
EDFSEDSEVQQILFYEDSVAAHLSKILTSDQHSVVISSAKVLCETVKDFVARVGKAYEKTTESSEESEVMAKKCSVLKEKLDSLLKTLDD
ESQASSSLPNPPPTIAEEAEDGDGSGSICGSTGDRLVASACPARPQIFRPREQLMLRANSLKKAIRQIIEHTEKAVDEQNAQTQEQEGFV
LGLSESEEKMDHRVCPPLSHSESFGVPKGRSQRKVSKSPCEKLISKGSLSLGSSASLPPQPGSRDGLPALNTKILYPNVRAGMSGSLPGG
SVISRLLINADPFNSEPETLEYYTEKCVMNNYFGIGLDAKISLDFNNKRDEHPEKCRSRTKNMMWYGVLGTKELLHRTYKNLEQKVLLEC
DGRPIPLPSLQGIAVLNIPSYAGGTNFWGGTKEDDTFAAPSFDDKILEVVAVFGSMQMAVSRVIRLQHHRIAQCRTVKISILGDEGVPVQ
VDGEAWVQPPGYIRIVHKNRAQTLTRDRAFESTLKSWEDKQKCELPRPPSCSLHPEMLSEEEATQMDQFGQAAGVLIHSIREIAQSHRDM
EQELAHAVNASSKSMDRVYGKPRTTEGLNCSFVLEMVNNFRALRSETELLLSGKMALQLDPPQKEQLGSALAEMDRQLRRLADTPWLCQS
AEPGDEESVMLDLAKRSRSGKFRLVTKFKKEKNNKNKEAHSSLGAPVHLWGTEEVAAWLEHLSLCEYKDIFTRHDIRGSELLHLERRDLK
DLGVTKVGHMKRILCGIKELSRSAPAVEA

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Fusion Gene PPI Analysis for CDKN2B-DGKD


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for CDKN2B-DGKD


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for CDKN2B-DGKD


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneCDKN2BC0017638Glioma2CGI;CTD_human
HgeneCDKN2BC0259783mixed gliomas2CTD_human
HgeneCDKN2BC0555198Malignant Glioma2CTD_human
HgeneCDKN2BC0010054Coronary Arteriosclerosis1CTD_human
HgeneCDKN2BC0017601Glaucoma1CTD_human
HgeneCDKN2BC0024299Lymphoma1CTD_human
HgeneCDKN2BC0025267Multiple Endocrine Neoplasia Type 11ORPHANET
HgeneCDKN2BC1956346Coronary Artery Disease1CTD_human
HgeneCDKN2BC2713368Hematopoetic Myelodysplasia1CTD_human
HgeneCDKN2BC3463824MYELODYSPLASTIC SYNDROME1CTD_human
TgeneC0011860Diabetes Mellitus, Non-Insulin-Dependent1CTD_human