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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ABCA7-COL5A3 (FusionGDB2 ID:HG10347TG50509)

Fusion Gene Summary for ABCA7-COL5A3

check button Fusion gene summary
Fusion gene informationFusion gene name: ABCA7-COL5A3
Fusion gene ID: hg10347tg50509
HgeneTgene
Gene symbol

ABCA7

COL5A3

Gene ID

10347

50509

Gene nameATP binding cassette subfamily A member 7collagen type V alpha 3 chain
SynonymsABCA-SSN|ABCX|AD9-
Cytomap('ABCA7')('COL5A3')

19p13.3

19p13.2

Type of geneprotein-codingprotein-coding
Descriptionphospholipid-transporting ATPase ABCA7ATP-binding cassette sub-family A member 7ATP-binding cassette, sub-family A (ABC1), member 7autoantigen SS-Nmacrophage ABC transportercollagen alpha-3(V) chaincollagen, type V, alpha 3pro-(alpha)3(V) collagen
Modification date2020032020200313
UniProtAcc

Q8IZY2

P25940

Ensembl transtripts involved in fusion geneENST00000263094, ENST00000433129, 
ENST00000435683, ENST00000533574, 
Fusion gene scores* DoF score5 X 5 X 3=756 X 5 X 6=180
# samples 57
** MAII scorelog2(5/75*10)=-0.584962500721156
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(7/180*10)=-1.36257007938471
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ABCA7 [Title/Abstract] AND COL5A3 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointABCA7(1059084)-COL5A3(10114821), # samples:3
Anticipated loss of major functional domain due to fusion event.ABCA7-COL5A3 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ABCA7-COL5A3 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ABCA7-COL5A3 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ABCA7-COL5A3 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneABCA7

GO:0033344

cholesterol efflux

14570867

HgeneABCA7

GO:0033700

phospholipid efflux

14570867

HgeneABCA7

GO:0034380

high-density lipoprotein particle assembly

14570867

HgeneABCA7

GO:0038027

apolipoprotein A-I-mediated signaling pathway

14570867

HgeneABCA7

GO:0045332

phospholipid translocation

24097981


check buttonFusion gene breakpoints across ABCA7 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across COL5A3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4KIRPTCGA-B9-A44B-01AABCA7chr19

1059084

-COL5A3chr19

10114821

-
ChimerDB4KIRPTCGA-B9-A44B-01AABCA7chr19

1059084

+COL5A3chr19

10114821

-
ChimerDB4KIRPTCGA-B9-A44BABCA7chr19

1059084

+COL5A3chr19

10114821

-


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Fusion Gene ORF analysis for ABCA7-COL5A3

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000263094ENST00000264828ABCA7chr19

1059084

+COL5A3chr19

10114821

-
In-frameENST00000433129ENST00000264828ABCA7chr19

1059084

+COL5A3chr19

10114821

-
In-frameENST00000435683ENST00000264828ABCA7chr19

1059084

+COL5A3chr19

10114821

-
intron-3CDSENST00000533574ENST00000264828ABCA7chr19

1059084

+COL5A3chr19

10114821

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000263094ABCA7chr191059084+ENST00000264828COL5A3chr1910114821-111885694153103373394
ENST00000433129ABCA7chr191059084+ENST00000264828COL5A3chr1910114821-1095754630101063368
ENST00000435683ABCA7chr191059084+ENST00000264828COL5A3chr1910114821-105435049096923230

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000263094ENST00000264828ABCA7chr191059084+COL5A3chr1910114821-0.0058032390.9941968
ENST00000433129ENST00000264828ABCA7chr191059084+COL5A3chr1910114821-0.0044148780.9955851
ENST00000435683ENST00000264828ABCA7chr191059084+COL5A3chr1910114821-0.0042715810.99572843

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Fusion Genomic Features for ABCA7-COL5A3


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

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Fusion Protein Features for ABCA7-COL5A3


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:1059084/chr19:10114821)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ABCA7

Q8IZY2

COL5A3

P25940

FUNCTION: Catalyzes the translocation of specific phospholipids from the cytoplasmic to the extracellular/lumenal leaflet of membrane coupled to the hydrolysis of ATP (PubMed:24097981). Transports preferentially phosphatidylserine over phosphatidylcholine (PubMed:24097981). Plays a role in lipid homeostasis and macrophage-mediated phagocytosis (PubMed:14592415, PubMed:12917409, PubMed:12925201, PubMed:14570867). Binds APOA1 and may function in apolipoprotein-mediated phospholipid efflux from cells (PubMed:12917409, PubMed:14570867, PubMed:14592415). May also mediate cholesterol efflux (PubMed:14570867). May regulate cellular ceramide homeostasis during keratinocyte differentiation (PubMed:12925201). Involved in lipid raft organization and CD1D localization on thymocytes and antigen-presenting cells, which plays an important role in natural killer T-cell development and activation (By similarity). Plays a role in phagocytosis of apoptotic cells by macrophages (By similarity). Macrophage phagocytosis is stimulated by APOA1 or APOA2, probably by stabilization of ABCA7 (By similarity). Also involved in phagocytic clearance of amyloid-beta by microglia cells and macrophages (By similarity). Further limits amyloid-beta production by playing a role in the regulation of amyloid-beta A4 precursor protein (APP) endocytosis and/or processing (PubMed:26260791). Amyloid-beta is the main component of amyloid plaques found in the brains of Alzheimer patients (PubMed:26260791). {ECO:0000250|UniProtKB:Q91V24, ECO:0000269|PubMed:12917409, ECO:0000269|PubMed:12925201, ECO:0000269|PubMed:14570867, ECO:0000269|PubMed:14592415, ECO:0000269|PubMed:24097981, ECO:0000269|PubMed:26260791}.FUNCTION: Type V collagen is a member of group I collagen (fibrillar forming collagen). It is a minor connective tissue component of nearly ubiquitous distribution. Type V collagen binds to DNA, heparan sulfate, thrombospondin, heparin, and insulin.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneABCA7chr19:1059084chr19:10114821ENST00000263094+4047807_103818212147.0DomainABC transporter 1
HgeneABCA7chr19:1059084chr19:10114821ENST00000433129+3946807_103818212147.0DomainABC transporter 1
HgeneABCA7chr19:1059084chr19:10114821ENST00000435683+3441807_103816832009.0DomainABC transporter 1
HgeneABCA7chr19:1059084chr19:10114821ENST00000263094+4047841_84818212147.0Nucleotide bindingATP 1
HgeneABCA7chr19:1059084chr19:10114821ENST00000433129+3946841_84818212147.0Nucleotide bindingATP 1
HgeneABCA7chr19:1059084chr19:10114821ENST00000435683+3441841_84816832009.0Nucleotide bindingATP 1
HgeneABCA7chr19:1059084chr19:10114821ENST00000263094+40471264_153718212147.0Topological domainExtracellular
HgeneABCA7chr19:1059084chr19:10114821ENST00000263094+404743_54918212147.0Topological domainExtracellular
HgeneABCA7chr19:1059084chr19:10114821ENST00000433129+39461264_153718212147.0Topological domainExtracellular
HgeneABCA7chr19:1059084chr19:10114821ENST00000433129+394643_54918212147.0Topological domainExtracellular
HgeneABCA7chr19:1059084chr19:10114821ENST00000435683+34411264_153716832009.0Topological domainExtracellular
HgeneABCA7chr19:1059084chr19:10114821ENST00000435683+344143_54916832009.0Topological domainExtracellular
HgeneABCA7chr19:1059084chr19:10114821ENST00000263094+40471243_126318212147.0TransmembraneHelical
HgeneABCA7chr19:1059084chr19:10114821ENST00000263094+40471538_155818212147.0TransmembraneHelical
HgeneABCA7chr19:1059084chr19:10114821ENST00000263094+40471584_160418212147.0TransmembraneHelical
HgeneABCA7chr19:1059084chr19:10114821ENST00000263094+40471621_164118212147.0TransmembraneHelical
HgeneABCA7chr19:1059084chr19:10114821ENST00000263094+40471649_166918212147.0TransmembraneHelical
HgeneABCA7chr19:1059084chr19:10114821ENST00000263094+40471683_170318212147.0TransmembraneHelical
HgeneABCA7chr19:1059084chr19:10114821ENST00000263094+40471729_174918212147.0TransmembraneHelical
HgeneABCA7chr19:1059084chr19:10114821ENST00000263094+404722_4218212147.0TransmembraneHelical
HgeneABCA7chr19:1059084chr19:10114821ENST00000263094+4047550_57018212147.0TransmembraneHelical
HgeneABCA7chr19:1059084chr19:10114821ENST00000263094+4047593_61318212147.0TransmembraneHelical
HgeneABCA7chr19:1059084chr19:10114821ENST00000263094+4047626_64618212147.0TransmembraneHelical
HgeneABCA7chr19:1059084chr19:10114821ENST00000263094+4047655_67518212147.0TransmembraneHelical
HgeneABCA7chr19:1059084chr19:10114821ENST00000263094+4047687_70718212147.0TransmembraneHelical
HgeneABCA7chr19:1059084chr19:10114821ENST00000263094+4047727_74718212147.0TransmembraneHelical
HgeneABCA7chr19:1059084chr19:10114821ENST00000263094+4047849_86918212147.0TransmembraneHelical
HgeneABCA7chr19:1059084chr19:10114821ENST00000433129+39461243_126318212147.0TransmembraneHelical
HgeneABCA7chr19:1059084chr19:10114821ENST00000433129+39461538_155818212147.0TransmembraneHelical
HgeneABCA7chr19:1059084chr19:10114821ENST00000433129+39461584_160418212147.0TransmembraneHelical
HgeneABCA7chr19:1059084chr19:10114821ENST00000433129+39461621_164118212147.0TransmembraneHelical
HgeneABCA7chr19:1059084chr19:10114821ENST00000433129+39461649_166918212147.0TransmembraneHelical
HgeneABCA7chr19:1059084chr19:10114821ENST00000433129+39461683_170318212147.0TransmembraneHelical
HgeneABCA7chr19:1059084chr19:10114821ENST00000433129+39461729_174918212147.0TransmembraneHelical
HgeneABCA7chr19:1059084chr19:10114821ENST00000433129+394622_4218212147.0TransmembraneHelical
HgeneABCA7chr19:1059084chr19:10114821ENST00000433129+3946550_57018212147.0TransmembraneHelical
HgeneABCA7chr19:1059084chr19:10114821ENST00000433129+3946593_61318212147.0TransmembraneHelical
HgeneABCA7chr19:1059084chr19:10114821ENST00000433129+3946626_64618212147.0TransmembraneHelical
HgeneABCA7chr19:1059084chr19:10114821ENST00000433129+3946655_67518212147.0TransmembraneHelical
HgeneABCA7chr19:1059084chr19:10114821ENST00000433129+3946687_70718212147.0TransmembraneHelical
HgeneABCA7chr19:1059084chr19:10114821ENST00000433129+3946727_74718212147.0TransmembraneHelical
HgeneABCA7chr19:1059084chr19:10114821ENST00000433129+3946849_86918212147.0TransmembraneHelical
HgeneABCA7chr19:1059084chr19:10114821ENST00000435683+34411243_126316832009.0TransmembraneHelical
HgeneABCA7chr19:1059084chr19:10114821ENST00000435683+34411538_155816832009.0TransmembraneHelical
HgeneABCA7chr19:1059084chr19:10114821ENST00000435683+34411584_160416832009.0TransmembraneHelical
HgeneABCA7chr19:1059084chr19:10114821ENST00000435683+34411621_164116832009.0TransmembraneHelical
HgeneABCA7chr19:1059084chr19:10114821ENST00000435683+34411649_166916832009.0TransmembraneHelical
HgeneABCA7chr19:1059084chr19:10114821ENST00000435683+344122_4216832009.0TransmembraneHelical
HgeneABCA7chr19:1059084chr19:10114821ENST00000435683+3441550_57016832009.0TransmembraneHelical
HgeneABCA7chr19:1059084chr19:10114821ENST00000435683+3441593_61316832009.0TransmembraneHelical
HgeneABCA7chr19:1059084chr19:10114821ENST00000435683+3441626_64616832009.0TransmembraneHelical
HgeneABCA7chr19:1059084chr19:10114821ENST00000435683+3441655_67516832009.0TransmembraneHelical
HgeneABCA7chr19:1059084chr19:10114821ENST00000435683+3441687_70716832009.0TransmembraneHelical
HgeneABCA7chr19:1059084chr19:10114821ENST00000435683+3441727_74716832009.0TransmembraneHelical
HgeneABCA7chr19:1059084chr19:10114821ENST00000435683+3441849_86916832009.0TransmembraneHelical
TgeneCOL5A3chr19:1059084chr19:10114821ENST000002648283671430_14881981746.0DomainNote=Collagen-like 6
TgeneCOL5A3chr19:1059084chr19:10114821ENST000002648283671514_17441981746.0DomainFibrillar collagen NC1
TgeneCOL5A3chr19:1059084chr19:10114821ENST00000264828367391_4401981746.0DomainNote=Collagen-like 1
TgeneCOL5A3chr19:1059084chr19:10114821ENST00000264828367482_5381981746.0DomainNote=Collagen-like 2
TgeneCOL5A3chr19:1059084chr19:10114821ENST00000264828367824_8771981746.0DomainNote=Collagen-like 3
TgeneCOL5A3chr19:1059084chr19:10114821ENST00000264828367905_9501981746.0DomainNote=Collagen-like 4
TgeneCOL5A3chr19:1059084chr19:10114821ENST00000264828367951_9891981746.0DomainNote=Collagen-like 5
TgeneCOL5A3chr19:1059084chr19:10114821ENST00000264828367211_3911981746.0RegionNote=Nonhelical region
TgeneCOL5A3chr19:1059084chr19:10114821ENST00000264828367392_14891981746.0RegionNote=Triple-helical region

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneABCA7chr19:1059084chr19:10114821ENST00000263094+40471793_202518212147.0DomainABC transporter 2
HgeneABCA7chr19:1059084chr19:10114821ENST00000433129+39461793_202518212147.0DomainABC transporter 2
HgeneABCA7chr19:1059084chr19:10114821ENST00000435683+34411793_202516832009.0DomainABC transporter 2
HgeneABCA7chr19:1059084chr19:10114821ENST00000263094+40471827_183418212147.0Nucleotide bindingATP 2
HgeneABCA7chr19:1059084chr19:10114821ENST00000433129+39461827_183418212147.0Nucleotide bindingATP 2
HgeneABCA7chr19:1059084chr19:10114821ENST00000435683+34411827_183416832009.0Nucleotide bindingATP 2
HgeneABCA7chr19:1059084chr19:10114821ENST00000435683+34411683_170316832009.0TransmembraneHelical
HgeneABCA7chr19:1059084chr19:10114821ENST00000435683+34411729_174916832009.0TransmembraneHelical
TgeneCOL5A3chr19:1059084chr19:10114821ENST0000026482836762_2241981746.0DomainNote=Laminin G-like


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Fusion Gene Sequence for ABCA7-COL5A3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>203_203_1_ABCA7-COL5A3_ABCA7_chr19_1059084_ENST00000263094_COL5A3_chr19_10114821_ENST00000264828_length(transcript)=11188nt_BP=5694nt
GGGCAAGCTCAGCGCACTTGGCTTAAGGGGCGGCGCGCTCCCTGCCTGCTGCTGGGCGGAGGGAAGGCGGCAAGAGCTGCGGAGCCCCTG
GAAGAGCTTCCAGGAACCCTGCGCTGTGGGATAAAGGAATGAGGTTCAGAAAGGGGCAGGGAGTTGCCCGCAGCCGCACCGCACGTCTTC
AGCCCGACCGTTGTCCTGACCTCTCTGTCCCGTCCCCTGCCCAGTCTCACCATGGCCTTCTGGACACAGCTGATGCTGCTGCTCTGGAAG
AATTTCATGTATCGCCGGAGACAGCCGGTCCAGCTCCTGGTCGAATTGCTGTGGCCTCTCTTCCTCTTCTTCATCCTGGTGGCTGTTCGC
CACTCCCACCCGCCCCTGGAGCACCATGAATGCCACTTCCCAAACAAGCCACTGCCATCGGCGGGCACCGTGCCCTGGCTCCAGGGTCTC
ATCTGTAATGTGAACAACACCTGCTTTCCGCAGCTGACACCGGGCGAGGAGCCCGGGCGCCTGAGCAACTTCAACGACTCCCTGGTCTCC
CGGCTGCTAGCCGATGCCCGCACTGTGCTGGGAGGGGCCAGTGCCCACAGGACGCTGGCTGGCCTAGGGAAGCTGATCGCCACGCTGAGG
GCTGCACGCAGCACGGCCCAGCCTCAACCAACCAAGCAGTCTCCACTGGAACCACCCATGCTGGATGTCGCGGAGCTGCTGACGTCACTG
CTGCGCACGGAATCCCTGGGGTTGGCACTGGGCCAAGCCCAGGAGCCCTTGCACAGCTTGTTGGAGGCCGCTGAGGACCTGGCCCAGGAG
CTCCTGGCGCTGCGCAGCCTGGTGGAGCTTCGGGCACTGCTGCAGAGACCCCGAGGGACCAGCGGCCCCCTGGAGTTGCTGTCAGAGGCC
CTCTGCAGTGTCAGGGGACCTAGCAGCACAGTGGGCCCCTCCCTCAACTGGTACGAGGCTAGTGACCTGATGGAGCTGGTGGGGCAGGAG
CCAGAATCCGCCCTGCCAGACAGCAGCCTGAGCCCCGCCTGCTCGGAGCTGATTGGAGCCCTGGACAGCCACCCGCTGTCCCGCCTGCTC
TGGAGACGCCTGAAGCCTCTGATCCTCGGGAAGCTACTCTTTGCACCAGATACACCTTTTACCCGGAAGCTCATGGCCCAGGTGAACCGG
ACCTTCGAGGAGCTCACCCTGCTGAGGGATGTCCGGGAGGTGTGGGAGATGCTGGGACCCCGGATCTTCACCTTCATGAACGACAGTTCC
AATGTGGCCATGCTGCAGCGGCTCCTGCAGATGCAGGATGAAGGAAGAAGGCAGCCCAGACCTGGAGGCCGGGACCACATGGAGGCCCTG
CGATCCTTTCTGGACCCTGGGAGCGGTGGCTACAGCTGGCAGGACGCACACGCTGATGTGGGGCACCTGGTGGGCACGCTGGGCCGAGTG
ACGGAGTGCCTGTCCTTGGACAAGCTGGAGGCGGCACCCTCAGAGGCAGCCCTGGTGTCGCGGGCCCTGCAACTGCTCGCGGAACATCGA
TTCTGGGCCGGCGTCGTCTTCTTGGGACCTGAGGACTCTTCAGACCCCACAGAGCACCCAACCCCAGACCTGGGCCCCGGCCACGTGCGC
ATCAAAATCCGCATGGACATTGACGTGGTCACGAGGACCAATAAGATCAGGGACAGGTTTTGGGACCCTGGCCCAGCCGCGGACCCCCTG
ACCGACCTGCGCTACGTGTGGGGCGGCTTCGTGTACCTGCAAGACCTGGTGGAGCGTGCAGCCGTCCGCGTGCTCAGCGGCGCCAACCCC
CGGGCCGGCCTCTACCTGCAGCAGATGCCCTATCCGTGCTATGTGGACGACGTGTTCCTGCGTGTGCTGAGCCGGTCGCTGCCGCTCTTC
CTGACGCTGGCCTGGATCTACTCCGTGACACTGACAGTGAAGGCCGTGGTGCGGGAGAAGGAGACGCGGCTGCGGGACACCATGCGCGCC
ATGGGGCTCAGCCGCGCGGTGCTCTGGCTAGGCTGGTTCCTCAGCTGCCTCGGGCCCTTCCTGCTCAGCGCCGCACTGCTGGTTCTGGTG
CTCAAGCTGGGAGACATCCTCCCCTACAGCCACCCGGGCGTGGTCTTCCTGTTCTTGGCAGCCTTCGCGGTGGCCACGGTGACCCAGAGC
TTCCTGCTCAGCGCCTTCTTCTCCCGCGCCAACCTGGCTGCGGCCTGCGGCGGCCTGGCCTACTTCTCCCTCTACCTGCCCTACGTGCTG
TGTGTGGCTTGGCGGGACCGGCTGCCCGCGGGTGGCCGCGTGGCCGCGAGCCTGCTGTCGCCCGTGGCCTTCGGCTTCGGCTGCGAGAGC
CTGGCTCTGCTGGAGGAGCAGGGCGAGGGCGCGCAGTGGCACAACGTGGGCACCCGGCCTACGGCAGACGTCTTCAGCCTGGCCCAGGTC
TCTGGCCTTCTGCTGCTGGACGCGGCGCTCTACGGCCTCGCCACCTGGTACCTGGAAGCTGTGTGCCCAGGCCAGTACGGGATCCCTGAA
CCATGGAATTTTCCTTTTCGGAGGAGCTACTGGTGCGGACCTCGGCCCCCCAAGAGTCCAGCCCCTTGCCCCACCCCGCTGGACCCAAAG
GTGCTGGTAGAAGAGGCACCGCCCGGCCTGAGTCCTGGCGTCTCCGTTCGCAGCCTGGAGAAGCGCTTTCCTGGAAGCCCGCAGCCAGCC
CTGCGGGGGCTCAGCCTGGACTTCTACCAGGGCCACATCACCGCCTTCCTGGGCCACAACGGGGCCGGCAAGACCACCACCCTGTCCATC
TTGAGTGGCCTCTTCCCACCCAGTGGTGGCTCTGCCTTCATCCTGGGCCACGACGTCCGCTCCAGCATGGCCGCCATCCGGCCCCACCTG
GGCGTCTGTCCTCAGTACAACGTGCTGTTTGACATGCTGACCGTGGACGAGCACGTCTGGTTCTATGGGCGGCTGAAGGGTCTGAGTGCC
GCTGTAGTGGGCCCCGAGCAGGACCGTCTGCTGCAGGATGTGGGGCTGGTCTCCAAGCAGAGTGTGCAGACTCGCCACCTCTCTGGTGGG
ATGCAACGGAAGCTGTCCGTGGCCATTGCCTTTGTGGGCGGCTCCCAAGTTGTTATCCTGGACGAGCCTACGGCTGGCGTGGATCCTGCT
TCCCGCCGCGGTATTTGGGAGCTGCTGCTCAAATACCGAGAAGGTCGCACGCTGATCCTCTCCACCCACCACCTGGATGAGGCAGAGCTG
CTGGGAGACCGTGTGGCCGTGGTGGCAGGTGGCCGCTTGTGCTGCTGTGGCTCCCCACTCTTCCTGCGCCGTCACCTGGGCTCCGGCTAC
TACCTGACGCTGGTGAAGGCCCGCCTGCCCCTGACCACCAATGAGAAGGCTGACACTGACATGGAGGGCAGTGTGGACACCAGGCAGGAA
AAGAAGAATGGCAGCCAGGGCAGCAGAGTCGGCACTCCTCAGCTGCTGGCCCTGGTACAGCACTGGGTGCCCGGGGCACGGCTGGTGGAG
GAGCTGCCACACGAGCTGGTGCTGGTGCTGCCCTACACGGGTGCCCATGACGGCAGCTTCGCCACACTCTTCCGAGAGCTAGACACGCGG
CTGGCGGAGCTGAGGCTCACTGGCTACGGGATCTCCGACACCAGCCTCGAGGAGATCTTCCTGAAGGTGGTGGAGGAGTGTGCTGCGGAC
ACAGATATGGAGGATGGCAGCTGCGGGCAGCACCTATGCACAGGCATTGCTGGCCTAGACGTAACCCTACGGCTCAAGATGCCGCCACAG
GAGACAGCGCTGGAGAACGGGGAACCAGCTGGGTCAGCCCCAGAGACTGACCAGGGCTCTGGGCCAGACGCCGTGGGCCGGGTACAGGGC
TGGGCACTGACCCGCCAGCAGCTCCAGGCCCTGCTTCTCAAGCGCTTTCTGCTTGCCCGCCGCAGCCGCCGCGGCCTGTTCGCCCAGATC
GTGCTGCCTGCCCTCTTTGTGGGCCTGGCCCTCGTGTTCAGCCTCATCGTGCCTCCTTTCGGGCACTACCCGGCTCTGCGGCTCAGTCCC
ACCATGTACGGTGCTCAGGTGTCCTTCTTCAGTGAGGACGCCCCAGGGGACCCTGGACGTGCCCGGCTGCTCGAGGCGCTGCTGCAGGAG
GCAGGACTGGAGGAGCCCCCAGTGCAGCATAGCTCCCACAGGTTCTCGGCACCAGAAGTTCCTGCTGAAGTGGCCAAGGTCTTGGCCAGT
GGCAACTGGACCCCAGAGTCTCCATCCCCAGCCTGCCAGTGTAGCCGGCCCGGTGCCCGGCGCCTGCTGCCCGACTGCCCGGCTGCAGCT
GGTGGTCCCCCTCCGCCCCAGGCAGTGACCGGCTCTGGGGAAGTGGTTCAGAACCTGACAGGCCGGAACCTGTCTGACTTCCTGGTCAAG
ACCTACCCGCGCCTGGTGCGCCAGGGCCTGAAGACTAAGAAGTGGGTGAATGAGGTCAGATACGGAGGCTTCTCGCTGGGGGGCCGAGAC
CCAGGCCTGCCCTCGGGCCAAGAGTTGGGCCGCTCAGTGGAGGAGTTGTGGGCGCTGCTGAGTCCCCTGCCTGGCGGGGCCCTCGACCGT
GTCCTGAAAAACCTCACAGCCTGGGCTCACAGCCTGGATGCTCAGGACAGTCTCAAGATCTGGTTCAACAACAAAGGCTGGCACTCCATG
GTGGCCTTTGTCAACCGAGCCAGCAACGCAATCCTCCGTGCTCACCTGCCCCCAGGCCCGGCCCGCCACGCCCACAGCATCACCACACTC
AACCACCCCTTGAACCTCACCAAGGAGCAGCTGTCTGAGGGTGCACTGATGGCCTCCTCGGTGGACGTCCTCGTCTCCATCTGTGTGGTC
TTTGCCATGTCCTTTGTCCCGGCCAGCTTCACTCTTGTCCTCATTGAGGAGCGAGTCACCCGAGCCAAGCACCTGCAGCTCATGGGGGGC
CTGTCCCCCACCCTCTACTGGCTTGGCAACTTTCTCTGGGACATGTGTAACTACTTGGTGCCAGCATGCATCGTGGTGCTCATCTTTCTG
GCCTTCCAGCAGAGGGCATATGTGGCCCCTGCCAACCTGCCTGCTCTCCTGCTGTTGCTACTACTGTATGGCTGGTCGATCACACCGCTC
ATGTACCCAGCCTCCTTCTTCTTCTCCGTGCCCAGCACAGCCTATGTGGTGCTCACCTGCATAAACCTCTTTATTGGCATCAATGGAAGC
ATGGCCACCTTTGTGCTTGAGCTCTTCTCTGATCAGAAGCTGCAGGAGGTGAGCCGGATCTTGAAACAGGTCTTCCTTATCTTCCCCCAC
TTCTGCTTGGGCCGGGGGCTCATTGACATGGTGCGGAACCAGGCCATGGCTGATGCCTTTGAGCGCTTGGGAGACAGGCAGTTCCAGTCA
CCCCTGCGCTGGGAGGTGGTCGGCAAGAACCTCTTGGCCATGGTGATACAGGGGCCCCTCTTCCTTCTCTTCACACTACTGCTGCAGCAC
CGAAGCCAACTCCTGCCACAGCCCAGGGTGAGGTCTCTGCCACTCCTGGGAGAGGAGGACGAGGATGTAGCCCGTGAACGGGAGCGGGTG
GTCCAAGGAGCCACCCAGGGGGATGTGTTGGTGCTGAGGAACTTGACCAAGGTATACCGTGGGCAGAGGATGCCAGCTGTTGACCGCTTG
TGCCTGGGGATTCCCCCTGGTGAGGGAGACATTCAGGAGCTGCTGATAAGCCCAGATCCTCAGGCTGCCTTCCAGGCTTGTGAGCGGTAC
CTCCCCGACTGTGACAACCTGGCACCGGCAGCCACAGTGGCTCCCCAGGGTGAACCAGAAACCCCTCGTCCTCGGCGGAAGGGGAAGGGA
AAAGGGAGGAAGAAAGGGCGAGGTCGCAAGGGGAAGGGCAGGAAAAAGAACAAGGAAATTTGGACCTCAAGTCCACCTCCTGACTCCGCA
GAGAACCAGACCTCCACTGACATCCCCAAGACAGAGACTCCAGCTCCAAATCTGCCTCCGACCCCCACGCCTTTGGTCGTCACCTCCACT
GTGACTACTGGACTCAATGCCACGATCCTAGAGAGGAGCTTGGACCCTGACAGTGGAACCGAGCTGGGGACCCTGGAGACCAAGGCAGCC
AGGGAGGATGAAGAAGGAGATGATTCCACCATGGGCCCTGACTTCCGGGCAGCAGAATATCCATCTCGGACTCAGTTCCAGATCTTTCCT
GGTGCTGGAGAGAAAGGAGCAAAAGGAGAGCCCGCAGTGATTGAAAAGGGGCAGCAGTTTGAGGGACCTCCAGGAGCCCCAGGACCCCAA
GGGGTGGTTGGCCCCTCAGGCCCTCCCGGCCCCCCAGGATTCCCTGGCGACCCTGGTCCACCGGGCCCTGCTGGCCTCCCAGGAATCCCC
GGCATTGATGGGATCCGAGGCCCACCGGGCACTGTGATCATGATGCCGTTCCAGTTTGCAGGCGGCTCCTTTAAAGGCCCCCCAGTCTCA
TTCCAGCAGGCCCAGGCTCAGGCAGTTCTGCAGCAGACTCAGCTCTCTATGAAAGGCCCCCCTGGTCCAGTGGGGCTCACTGGGCGCCCA
GGCCCTGTGGGTCTCCCCGGGCATCCAGGTCTGAAAGGAGAGGAGGGAGCAGAAGGGCCACAGGGTCCCCGAGGCCTGCAGGGACCTCAT
GGACCCCCTGGCCGAGTGGGCAAGATGGGCCGCCCTGGAGCAGATGGAGCTCGGGGCCTCCCAGGGGACACTGGACCTAAGGGTGATCGT
GGCTTCGATGGCCTCCCTGGGCTGCCTGGTGAGAAGGGCCAAAGGGGTGACTTTGGCCATGTGGGGCAACCCGGTCCCCCAGGAGAGGAT
GGTGAGAGGGGAGCAGAGGGACCTCCAGGGCCCACTGGCCAGGCTGGGGAGCCGGGTCCACGAGGACTGCTTGGCCCCAGAGGCTCTCCT
GGCCCCACGGGTCGCCCGGGTGTGACTGGAATTGATGGTGCTCCTGGTGCCAAAGGCAATGTGGGTCCTCCAGGAGAACCAGGCCCTCCG
GGACAGCAGGGAAACCATGGGTCCCAGGGACTCCCCGGTCCCCAGGGACTCATTGGCACTCCTGGGGAGAAGGGTCCCCCTGGAAACCCA
GGAATTCCAGGCCTCCCAGGATCCGATGGCCCTCTGGGTCACCCAGGACATGAGGGCCCCACGGGAGAGAAAGGGGCTCAGGGTCCACCA
GGGTCGGCAGGCCCTCCGGGCTATCCTGGACCTCGGGGAGTGAAGGGCACTTCAGGCAACCGGGGCCTCCAGGGGGAGAAAGGCGAGAAG
GGAGAGGACGGCTTCCCAGGCTTCAAGGGCGATGTGGGGCTCAAAGGTGATCAGGGGAAACCCGGAGCTCCAGGTCCCCGGGGAGAGGAT
GGTCCTGAGGGGCCGAAGGGGCAGGCGGGGCAGGCTGGCGAGGAGGGGCCCCCAGGCTCAGCTGGGGAGAAGGGCAAGCTTGGGGTGCCA
GGCCTCCCAGGTTATCCAGGACGCCCTGGACCTAAGGGATCTATTGGATTTCCCGGTCCCCTGGGACCCATAGGAGAGAAAGGGAAGTCG
GGAAAGACAGGGCAGCCAGGCCTGGAAGGAGAGCGGGGACCACCAGGTTCCCGTGGAGAGAGGGGGCAACCGGGTGCCACAGGGCAACCA
GGCCCCAAGGGCGATGTGGGCCAGGATGGAGCCCCTGGGATCCCTGGAGAAAAGGGCCTCCCTGGTCTGCAAGGCCCTCCAGGATTCCCT
GGGCCAAAGGGCCCCCCTGGTCACCAAGGTAAAGATGGGCGACCAGGGCACCCTGGACAGAGAGGAGAACTGGGCTTCCAAGGTCAGACA
GGCCCGCCTGGACCAGCTGGTGTCTTAGGCCCTCAGGGAAAGACAGGAGAAGTGGGACCTCTAGGTGAAAGGGGGCCTCCAGGCCCCCCT
GGACCTCCTGGTGAACAAGGTCTTCCTGGCCTGGAAGGCAGAGAGGGGGCCAAGGGGGAACTGGGACCACCAGGACCCCTTGGGAAAGAA
GGGCCAGCTGGACTCAGGGGCTTTCCCGGCCCCAAAGGGGGCCCTGGGGACCCGGGACCTACTGGCTTAAAGGGTGATAAGGGCCCCCCA
GGGCCCGTGGGGGCCAATGGCTCCCCTGGTGAGCGCGGTCCTTTGGGCCCAGCAGGAGGCATTGGACTTCCTGGCCAAAGTGGCAGCGAA
GGCCCCGTTGGCCCTGCAGGCAAGAAGGGGTCCCGGGGAGAACGTGGCCCCCCTGGCCCCACTGGCAAAGATGGGATCCCAGGGCCCCTG
GGGCCTCTGGGACCCCCTGGAGCTGCTGGGCCTTCTGGCGAGGAAGGGGACAAGGGGGATGTGGGTGCCCCCGGACACAAGGGGAGTAAA
GGCGATAAAGGAGACGCGGGCCCACCTGGACAACCAGGGATACGGGGTCCTGCAGGACACCCAGGTCCCCCGGGAGCAGACGGGGCTCAG
GGGCGCCGGGGACCCCCAGGCCTCTTTGGGCAGAAAGGAGATGACGGAGTCAGAGGCTTTGTGGGGGTGATTGGCCCTCCTGGACTGCAG
GGGCTGCCAGGCCCTCCGGGAGAGAAAGGGGAGGTCGGAGACGTCGGGTCCATGGGTCCCCATGGAGCTCCAGGTCCTCGGGGTCCCCAA
GGCCCCACTGGATCAGAGGGCACTCCAGGGCTGCCTGGAGGAGTTGGTCAGCCAGGCGCCGTGGGTGAGAAGGGTGAGCGAGGGGACGCT
GGAGACCCAGGGCCTCCAGGAGCCCCAGGCATCCCGGGGCCCAAGGGAGACATTGGTGAAAAGGGGGACTCAGGCCCATCTGGAGCTGCT
GGACCCCCAGGCAAGAAAGGTCCCCCTGGAGAGGATGGAGCCAAAGGGAGCGTGGGCCCCACGGGGCTGCCCGGAGATCTAGGGCCCCCA
GGAGACCCTGGAGTTTCAGGCATAGATGGTTCCCCAGGGGAGAAGGGAGACCCTGGTGATGTTGGGGGACCGGGTCCGCCTGGAGCTTCT
GGGGAGCCCGGCGCCCCCGGGCCCCCCGGCAAGAGGGGTCCTTCAGGCCACATGGGTCGAGAAGGCAGAGAAGGGGAGAAAGGTGCCAAG
GGGGAGCCAGGTCCTGATGGGCCCCCAGGGAGGACGGGTCCAATGGGGGCTAGAGGGCCCCCTGGACGTGTGGGGCCTGAGGGTCTTCGA
GGGATCCCTGGCCCTGTGGGTGAACCAGGCCTCCTGGGAGCCCCTGGACAGATGGGCCCTCCTGGCCCCCTGGGGCCCTCTGGCCTCCCA
GGGCTGAAGGGAGACACTGGCCCCAAGGGGGAAAAGGGCCACATTGGATTGATCGGTCTCATTGGCCCCCCGGGAGAAGCTGGTGAGAAA
GGAGATCAGGGGTTGCCAGGCGTGCAGGGACCCCCTGGTCCCAAGGGAGACCCTGGTCCCCCTGGTCCCATTGGCTCTCTGGGCCACCCT
GGGCCCCCAGGTGTGGCGGGCCCTCTAGGACAGAAAGGCTCAAAAGGGTCTCCGGGGTCCATGGGCCCCCGTGGAGACACTGGACCTGCA
GGCCCACCAGGCCCCCCGGGTGCCCCTGCCGAGCTGCATGGGCTGCGCAGGCGCCGGCGCTTCGTCCCAGTCCCGCTTCCAGTCGTGGAG
GGCGGCCTGGAGGAGGTGCTGGCCTCGCTCACATCGCTGAGCTTGGAGCTGGAGCAGCTGCGGCGTCCTCCCGGCACTGCGGAGCGCCCG
GGCCTCGTGTGCCACGAGCTGCACCGCAACCACCCGCACCTGCCTGATGGGGAATACTGGATTGACCCCAACCAGGGCTGCGCGCGGGAC
TCGTTCAGGGTTTTTTGCAACTTCACGGCGGGAGGAGAGACCTGCCTCTATCCCGACAAGAAGTTTGAGATCGTGAAATTGGCCTCCTGG
TCCAAGGAAAAGCCTGGAGGCTGGTATAGCACATTCCGTCGAGGGAAGAAGTTCTCCTACGTGGACGCCGACGGGTCCCCAGTGAATGTC
GTGCAGCTGAACTTCCTGAAACTGCTGAGTGCCACAGCTCGCCAGAACTTCACCTACTCCTGCCAGAATGCAGCTGCCTGGCTGGACGAA
GCCACGGGTGACTACAGCCACTCCGCCCGCTTCCTTGGCACCAATGGAGAGGAGCTGTCTTTCAACCAGACGACAGCAGCCACTGTCAGC
GTCCCCCAGGATGGCTGCCGGCTCCGGAAAGGACAGACGAAGACCCTTTTCGAATTCAGCTCTTCTCGAGCGGGATTTCTGCCCCTGTGG
GATGTGGCGGCCACTGACTTTGGCCAGACGAACCAAAAGTTTGGGTTTGAACTGGGCCCCGTCTGCTTCAGCAGCTGAGAGTGTCCGGGG
TGGGAGGGACCATGAGGGAGCCCCAGAATGGGGTGCATTTGGTGCTGAGGCTTTGAAGCCACCGTATTTTTCGTTACCTGTGACTATGGA
GCCAATGGGATGTGACTTCGCTCATCACGGACAGTCATTCCTTCTCCTTTCCAGGGTGCTGGGGGCTGGGGTTCCCTGGCCCAAGGGTCC
AGCCTCCTCTCACCCCATTCCAGGTGGCATACTGCAGTCTGGCTCTTTCTCCCCTCCCTCCCCACCCAAGCCTCACCTCCCCACCCCTTG
AACCCCCATGCAATGAGCTTCTAACTCAGAGCTGATGAACAAAAGCCCCCCCACCCCCAATGCCTGCCTCCTCACTCCTCCGTCGCTGCC
CTTCACACCTTTTGGTGCTACCCCTCCCCAGAGTTAAGCACTGGATGTCTCCTGATCCCAGGCTGGGACCCCTACCCCCACCCCCTTTGA
TCCTTTCTACTTCCACGGTGAAAGGACTGAGGTCGGACTACAGAGGGAAGAGGGACTTCCCTTGACTGGGTTGTGTTTCTTTTCCTGCCT
CAGCCCAGCTCTGCAAATCCCCTCCCCCTGCCCCCCACCTCCCCAGGCTCACCTTGCCATGCCAGGTGGTTTGGGGACCAAGATGTTGGG
GGGGTGAATCAGGATCCTAATGGTGCTGCCCTATTTATACCTGGGTCTGTATTAAAAGGGAAAGTCCCCCCTGTTGTAGATTTCATCTGC
TTCCTCCTTAGGGAAGGCTGGGATATGATGAGAGATTCCAGCCCAAGCCTGGCCCCCCACCGCCAGGCCATAGGGCATAATTTGCATCTC

>203_203_1_ABCA7-COL5A3_ABCA7_chr19_1059084_ENST00000263094_COL5A3_chr19_10114821_ENST00000264828_length(amino acids)=3394AA_BP=2577
MPAAAPHVFSPTVVLTSLSRPLPSLTMAFWTQLMLLLWKNFMYRRRQPVQLLVELLWPLFLFFILVAVRHSHPPLEHHECHFPNKPLPSA
GTVPWLQGLICNVNNTCFPQLTPGEEPGRLSNFNDSLVSRLLADARTVLGGASAHRTLAGLGKLIATLRAARSTAQPQPTKQSPLEPPML
DVAELLTSLLRTESLGLALGQAQEPLHSLLEAAEDLAQELLALRSLVELRALLQRPRGTSGPLELLSEALCSVRGPSSTVGPSLNWYEAS
DLMELVGQEPESALPDSSLSPACSELIGALDSHPLSRLLWRRLKPLILGKLLFAPDTPFTRKLMAQVNRTFEELTLLRDVREVWEMLGPR
IFTFMNDSSNVAMLQRLLQMQDEGRRQPRPGGRDHMEALRSFLDPGSGGYSWQDAHADVGHLVGTLGRVTECLSLDKLEAAPSEAALVSR
ALQLLAEHRFWAGVVFLGPEDSSDPTEHPTPDLGPGHVRIKIRMDIDVVTRTNKIRDRFWDPGPAADPLTDLRYVWGGFVYLQDLVERAA
VRVLSGANPRAGLYLQQMPYPCYVDDVFLRVLSRSLPLFLTLAWIYSVTLTVKAVVREKETRLRDTMRAMGLSRAVLWLGWFLSCLGPFL
LSAALLVLVLKLGDILPYSHPGVVFLFLAAFAVATVTQSFLLSAFFSRANLAAACGGLAYFSLYLPYVLCVAWRDRLPAGGRVAASLLSP
VAFGFGCESLALLEEQGEGAQWHNVGTRPTADVFSLAQVSGLLLLDAALYGLATWYLEAVCPGQYGIPEPWNFPFRRSYWCGPRPPKSPA
PCPTPLDPKVLVEEAPPGLSPGVSVRSLEKRFPGSPQPALRGLSLDFYQGHITAFLGHNGAGKTTTLSILSGLFPPSGGSAFILGHDVRS
SMAAIRPHLGVCPQYNVLFDMLTVDEHVWFYGRLKGLSAAVVGPEQDRLLQDVGLVSKQSVQTRHLSGGMQRKLSVAIAFVGGSQVVILD
EPTAGVDPASRRGIWELLLKYREGRTLILSTHHLDEAELLGDRVAVVAGGRLCCCGSPLFLRRHLGSGYYLTLVKARLPLTTNEKADTDM
EGSVDTRQEKKNGSQGSRVGTPQLLALVQHWVPGARLVEELPHELVLVLPYTGAHDGSFATLFRELDTRLAELRLTGYGISDTSLEEIFL
KVVEECAADTDMEDGSCGQHLCTGIAGLDVTLRLKMPPQETALENGEPAGSAPETDQGSGPDAVGRVQGWALTRQQLQALLLKRFLLARR
SRRGLFAQIVLPALFVGLALVFSLIVPPFGHYPALRLSPTMYGAQVSFFSEDAPGDPGRARLLEALLQEAGLEEPPVQHSSHRFSAPEVP
AEVAKVLASGNWTPESPSPACQCSRPGARRLLPDCPAAAGGPPPPQAVTGSGEVVQNLTGRNLSDFLVKTYPRLVRQGLKTKKWVNEVRY
GGFSLGGRDPGLPSGQELGRSVEELWALLSPLPGGALDRVLKNLTAWAHSLDAQDSLKIWFNNKGWHSMVAFVNRASNAILRAHLPPGPA
RHAHSITTLNHPLNLTKEQLSEGALMASSVDVLVSICVVFAMSFVPASFTLVLIEERVTRAKHLQLMGGLSPTLYWLGNFLWDMCNYLVP
ACIVVLIFLAFQQRAYVAPANLPALLLLLLLYGWSITPLMYPASFFFSVPSTAYVVLTCINLFIGINGSMATFVLELFSDQKLQEVSRIL
KQVFLIFPHFCLGRGLIDMVRNQAMADAFERLGDRQFQSPLRWEVVGKNLLAMVIQGPLFLLFTLLLQHRSQLLPQPRVRSLPLLGEEDE
DVARERERVVQGATQGDVLVLRNLTKVYRGQRMPAVDRLCLGIPPGEGDIQELLISPDPQAAFQACERYLPDCDNLAPAATVAPQGEPET
PRPRRKGKGKGRKKGRGRKGKGRKKNKEIWTSSPPPDSAENQTSTDIPKTETPAPNLPPTPTPLVVTSTVTTGLNATILERSLDPDSGTE
LGTLETKAAREDEEGDDSTMGPDFRAAEYPSRTQFQIFPGAGEKGAKGEPAVIEKGQQFEGPPGAPGPQGVVGPSGPPGPPGFPGDPGPP
GPAGLPGIPGIDGIRGPPGTVIMMPFQFAGGSFKGPPVSFQQAQAQAVLQQTQLSMKGPPGPVGLTGRPGPVGLPGHPGLKGEEGAEGPQ
GPRGLQGPHGPPGRVGKMGRPGADGARGLPGDTGPKGDRGFDGLPGLPGEKGQRGDFGHVGQPGPPGEDGERGAEGPPGPTGQAGEPGPR
GLLGPRGSPGPTGRPGVTGIDGAPGAKGNVGPPGEPGPPGQQGNHGSQGLPGPQGLIGTPGEKGPPGNPGIPGLPGSDGPLGHPGHEGPT
GEKGAQGPPGSAGPPGYPGPRGVKGTSGNRGLQGEKGEKGEDGFPGFKGDVGLKGDQGKPGAPGPRGEDGPEGPKGQAGQAGEEGPPGSA
GEKGKLGVPGLPGYPGRPGPKGSIGFPGPLGPIGEKGKSGKTGQPGLEGERGPPGSRGERGQPGATGQPGPKGDVGQDGAPGIPGEKGLP
GLQGPPGFPGPKGPPGHQGKDGRPGHPGQRGELGFQGQTGPPGPAGVLGPQGKTGEVGPLGERGPPGPPGPPGEQGLPGLEGREGAKGEL
GPPGPLGKEGPAGLRGFPGPKGGPGDPGPTGLKGDKGPPGPVGANGSPGERGPLGPAGGIGLPGQSGSEGPVGPAGKKGSRGERGPPGPT
GKDGIPGPLGPLGPPGAAGPSGEEGDKGDVGAPGHKGSKGDKGDAGPPGQPGIRGPAGHPGPPGADGAQGRRGPPGLFGQKGDDGVRGFV
GVIGPPGLQGLPGPPGEKGEVGDVGSMGPHGAPGPRGPQGPTGSEGTPGLPGGVGQPGAVGEKGERGDAGDPGPPGAPGIPGPKGDIGEK
GDSGPSGAAGPPGKKGPPGEDGAKGSVGPTGLPGDLGPPGDPGVSGIDGSPGEKGDPGDVGGPGPPGASGEPGAPGPPGKRGPSGHMGRE
GREGEKGAKGEPGPDGPPGRTGPMGARGPPGRVGPEGLRGIPGPVGEPGLLGAPGQMGPPGPLGPSGLPGLKGDTGPKGEKGHIGLIGLI
GPPGEAGEKGDQGLPGVQGPPGPKGDPGPPGPIGSLGHPGPPGVAGPLGQKGSKGSPGSMGPRGDTGPAGPPGPPGAPAELHGLRRRRRF
VPVPLPVVEGGLEEVLASLTSLSLELEQLRRPPGTAERPGLVCHELHRNHPHLPDGEYWIDPNQGCARDSFRVFCNFTAGGETCLYPDKK
FEIVKLASWSKEKPGGWYSTFRRGKKFSYVDADGSPVNVVQLNFLKLLSATARQNFTYSCQNAAAWLDEATGDYSHSARFLGTNGEELSF

--------------------------------------------------------------
>203_203_2_ABCA7-COL5A3_ABCA7_chr19_1059084_ENST00000433129_COL5A3_chr19_10114821_ENST00000264828_length(transcript)=10957nt_BP=5463nt
ATGGCCTTCTGGACACAGCTGATGCTGCTGCTCTGGAAGAATTTCATGTATCGCCGGAGACAGCCGGTCCAGCTCCTGGTCGAATTGCTG
TGGCCTCTCTTCCTCTTCTTCATCCTGGTGGCTGTTCGCCACTCCCACCCGCCCCTGGAGCACCATGAATGCCACTTCCCAAACAAGCCA
CTGCCATCGGCGGGCACCGTGCCCTGGCTCCAGGGTCTCATCTGTAATGTGAACAACACCTGCTTTCCGCAGCTGACACCGGGCGAGGAG
CCCGGGCGCCTGAGCAACTTCAACGACTCCCTGGTCTCCCGGCTGCTAGCCGATGCCCGCACTGTGCTGGGAGGGGCCAGTGCCCACAGG
ACGCTGGCTGGCCTAGGGAAGCTGATCGCCACGCTGAGGGCTGCACGCAGCACGGCCCAGCCTCAACCAACCAAGCAGTCTCCACTGGAA
CCACCCATGCTGGATGTCGCGGAGCTGCTGACGTCACTGCTGCGCACGGAATCCCTGGGGTTGGCACTGGGCCAAGCCCAGGAGCCCTTG
CACAGCTTGTTGGAGGCCGCTGAGGACCTGGCCCAGGAGCTCCTGGCGCTGCGCAGCCTGGTGGAGCTTCGGGCACTGCTGCAGAGACCC
CGAGGGACCAGCGGCCCCCTGGAGTTGCTGTCAGAGGCCCTCTGCAGTGTCAGGGGACCTAGCAGCACAGTGGGCCCCTCCCTCAACTGG
TACGAGGCTAGTGACCTGATGGAGCTGGTGGGGCAGGAGCCAGAATCCGCCCTGCCAGACAGCAGCCTGAGCCCCGCCTGCTCGGAGCTG
ATTGGAGCCCTGGACAGCCACCCGCTGTCCCGCCTGCTCTGGAGACGCCTGAAGCCTCTGATCCTCGGGAAGCTACTCTTTGCACCAGAT
ACACCTTTTACCCGGAAGCTCATGGCCCAGGTGAACCGGACCTTCGAGGAGCTCACCCTGCTGAGGGATGTCCGGGAGGTGTGGGAGATG
CTGGGACCCCGGATCTTCACCTTCATGAACGACAGTTCCAATGTGGCCATGCTGCAGCGGCTCCTGCAGATGCAGGATGAAGGAAGAAGG
CAGCCCAGACCTGGAGGCCGGGACCACATGGAGGCCCTGCGATCCTTTCTGGACCCTGGGAGCGGTGGCTACAGCTGGCAGGACGCACAC
GCTGATGTGGGGCACCTGGTGGGCACGCTGGGCCGAGTGACGGAGTGCCTGTCCTTGGACAAGCTGGAGGCGGCACCCTCAGAGGCAGCC
CTGGTGTCGCGGGCCCTGCAACTGCTCGCGGAACATCGATTCTGGGCCGGCGTCGTCTTCTTGGGACCTGAGGACTCTTCAGACCCCACA
GAGCACCCAACCCCAGACCTGGGCCCCGGCCACGTGCGCATCAAAATCCGCATGGACATTGACGTGGTCACGAGGACCAATAAGATCAGG
GACAGGTTTTGGGACCCTGGCCCAGCCGCGGACCCCCTGACCGACCTGCGCTACGTGTGGGGCGGCTTCGTGTACCTGCAAGACCTGGTG
GAGCGTGCAGCCGTCCGCGTGCTCAGCGGCGCCAACCCCCGGGCCGGCCTCTACCTGCAGCAGATGCCCTATCCGTGCTATGTGGACGAC
GTGTTCCTGCGTGTGCTGAGCCGGTCGCTGCCGCTCTTCCTGACGCTGGCCTGGATCTACTCCGTGACACTGACAGTGAAGGCCGTGGTG
CGGGAGAAGGAGACGCGGCTGCGGGACACCATGCGCGCCATGGGGCTCAGCCGCGCGGTGCTCTGGCTAGGCTGGTTCCTCAGCTGCCTC
GGGCCCTTCCTGCTCAGCGCCGCACTGCTGGTTCTGGTGCTCAAGCTGGGAGACATCCTCCCCTACAGCCACCCGGGCGTGGTCTTCCTG
TTCTTGGCAGCCTTCGCGGTGGCCACGGTGACCCAGAGCTTCCTGCTCAGCGCCTTCTTCTCCCGCGCCAACCTGGCTGCGGCCTGCGGC
GGCCTGGCCTACTTCTCCCTCTACCTGCCCTACGTGCTGTGTGTGGCTTGGCGGGACCGGCTGCCCGCGGGTGGCCGCGTGGCCGCGAGC
CTGCTGTCGCCCGTGGCCTTCGGCTTCGGCTGCGAGAGCCTGGCTCTGCTGGAGGAGCAGGGCGAGGGCGCGCAGTGGCACAACGTGGGC
ACCCGGCCTACGGCAGACGTCTTCAGCCTGGCCCAGGTCTCTGGCCTTCTGCTGCTGGACGCGGCGCTCTACGGCCTCGCCACCTGGTAC
CTGGAAGCTGTGTGCCCAGGCCAGTACGGGATCCCTGAACCATGGAATTTTCCTTTTCGGAGGAGCTACTGGTGCGGACCTCGGCCCCCC
AAGAGTCCAGCCCCTTGCCCCACCCCGCTGGACCCAAAGGTGCTGGTAGAAGAGGCACCGCCCGGCCTGAGTCCTGGCGTCTCCGTTCGC
AGCCTGGAGAAGCGCTTTCCTGGAAGCCCGCAGCCAGCCCTGCGGGGGCTCAGCCTGGACTTCTACCAGGGCCACATCACCGCCTTCCTG
GGCCACAACGGGGCCGGCAAGACCACCACCCTGTCCATCTTGAGTGGCCTCTTCCCACCCAGTGGTGGCTCTGCCTTCATCCTGGGCCAC
GACGTCCGCTCCAGCATGGCCGCCATCCGGCCCCACCTGGGCGTCTGTCCTCAGTACAACGTGCTGTTTGACATGCTGACCGTGGACGAG
CACGTCTGGTTCTATGGGCGGCTGAAGGGTCTGAGTGCCGCTGTAGTGGGCCCCGAGCAGGACCGTCTGCTGCAGGATGTGGGGCTGGTC
TCCAAGCAGAGTGTGCAGACTCGCCACCTCTCTGGTGGGATGCAACGGAAGCTGTCCGTGGCCATTGCCTTTGTGGGCGGCTCCCAAGTT
GTTATCCTGGACGAGCCTACGGCTGGCGTGGATCCTGCTTCCCGCCGCGGTATTTGGGAGCTGCTGCTCAAATACCGAGAAGGTCGCACG
CTGATCCTCTCCACCCACCACCTGGATGAGGCAGAGCTGCTGGGAGACCGTGTGGCCGTGGTGGCAGGTGGCCGCTTGTGCTGCTGTGGC
TCCCCACTCTTCCTGCGCCGTCACCTGGGCTCCGGCTACTACCTGACGCTGGTGAAGGCCCGCCTGCCCCTGACCACCAATGAGAAGGCT
GACACTGACATGGAGGGCAGTGTGGACACCAGGCAGGAAAAGAAGAATGGCAGCCAGGGCAGCAGAGTCGGCACTCCTCAGCTGCTGGCC
CTGGTACAGCACTGGGTGCCCGGGGCACGGCTGGTGGAGGAGCTGCCACACGAGCTGGTGCTGGTGCTGCCCTACACGGGTGCCCATGAC
GGCAGCTTCGCCACACTCTTCCGAGAGCTAGACACGCGGCTGGCGGAGCTGAGGCTCACTGGCTACGGGATCTCCGACACCAGCCTCGAG
GAGATCTTCCTGAAGGTGGTGGAGGAGTGTGCTGCGGACACAGATATGGAGGATGGCAGCTGCGGGCAGCACCTATGCACAGGCATTGCT
GGCCTAGACGTAACCCTACGGCTCAAGATGCCGCCACAGGAGACAGCGCTGGAGAACGGGGAACCAGCTGGGTCAGCCCCAGAGACTGAC
CAGGGCTCTGGGCCAGACGCCGTGGGCCGGGTACAGGGCTGGGCACTGACCCGCCAGCAGCTCCAGGCCCTGCTTCTCAAGCGCTTTCTG
CTTGCCCGCCGCAGCCGCCGCGGCCTGTTCGCCCAGATCGTGCTGCCTGCCCTCTTTGTGGGCCTGGCCCTCGTGTTCAGCCTCATCGTG
CCTCCTTTCGGGCACTACCCGGCTCTGCGGCTCAGTCCCACCATGTACGGTGCTCAGGTGTCCTTCTTCAGTGAGGACGCCCCAGGGGAC
CCTGGACGTGCCCGGCTGCTCGAGGCGCTGCTGCAGGAGGCAGGACTGGAGGAGCCCCCAGTGCAGCATAGCTCCCACAGGTTCTCGGCA
CCAGAAGTTCCTGCTGAAGTGGCCAAGGTCTTGGCCAGTGGCAACTGGACCCCAGAGTCTCCATCCCCAGCCTGCCAGTGTAGCCGGCCC
GGTGCCCGGCGCCTGCTGCCCGACTGCCCGGCTGCAGCTGGTGGTCCCCCTCCGCCCCAGGCAGTGACCGGCTCTGGGGAAGTGGTTCAG
AACCTGACAGGCCGGAACCTGTCTGACTTCCTGGTCAAGACCTACCCGCGCCTGGTGCGCCAGGGCCTGAAGACTAAGAAGTGGGTGAAT
GAGGTCAGATACGGAGGCTTCTCGCTGGGGGGCCGAGACCCAGGCCTGCCCTCGGGCCAAGAGTTGGGCCGCTCAGTGGAGGAGTTGTGG
GCGCTGCTGAGTCCCCTGCCTGGCGGGGCCCTCGACCGTGTCCTGAAAAACCTCACAGCCTGGGCTCACAGCCTGGATGCTCAGGACAGT
CTCAAGATCTGGTTCAACAACAAAGGCTGGCACTCCATGGTGGCCTTTGTCAACCGAGCCAGCAACGCAATCCTCCGTGCTCACCTGCCC
CCAGGCCCGGCCCGCCACGCCCACAGCATCACCACACTCAACCACCCCTTGAACCTCACCAAGGAGCAGCTGTCTGAGGGTGCACTGATG
GCCTCCTCGGTGGACGTCCTCGTCTCCATCTGTGTGGTCTTTGCCATGTCCTTTGTCCCGGCCAGCTTCACTCTTGTCCTCATTGAGGAG
CGAGTCACCCGAGCCAAGCACCTGCAGCTCATGGGGGGCCTGTCCCCCACCCTCTACTGGCTTGGCAACTTTCTCTGGGACATGTGTAAC
TACTTGGTGCCAGCATGCATCGTGGTGCTCATCTTTCTGGCCTTCCAGCAGAGGGCATATGTGGCCCCTGCCAACCTGCCTGCTCTCCTG
CTGTTGCTACTACTGTATGGCTGGTCGATCACACCGCTCATGTACCCAGCCTCCTTCTTCTTCTCCGTGCCCAGCACAGCCTATGTGGTG
CTCACCTGCATAAACCTCTTTATTGGCATCAATGGAAGCATGGCCACCTTTGTGCTTGAGCTCTTCTCTGATCAGAAGCTGCAGGAGGTG
AGCCGGATCTTGAAACAGGTCTTCCTTATCTTCCCCCACTTCTGCTTGGGCCGGGGGCTCATTGACATGGTGCGGAACCAGGCCATGGCT
GATGCCTTTGAGCGCTTGGGAGACAGGCAGTTCCAGTCACCCCTGCGCTGGGAGGTGGTCGGCAAGAACCTCTTGGCCATGGTGATACAG
GGGCCCCTCTTCCTTCTCTTCACACTACTGCTGCAGCACCGAAGCCAACTCCTGCCACAGCCCAGGGTGAGGTCTCTGCCACTCCTGGGA
GAGGAGGACGAGGATGTAGCCCGTGAACGGGAGCGGGTGGTCCAAGGAGCCACCCAGGGGGATGTGTTGGTGCTGAGGAACTTGACCAAG
GTATACCGTGGGCAGAGGATGCCAGCTGTTGACCGCTTGTGCCTGGGGATTCCCCCTGGTGAGGGAGACATTCAGGAGCTGCTGATAAGC
CCAGATCCTCAGGCTGCCTTCCAGGCTTGTGAGCGGTACCTCCCCGACTGTGACAACCTGGCACCGGCAGCCACAGTGGCTCCCCAGGGT
GAACCAGAAACCCCTCGTCCTCGGCGGAAGGGGAAGGGAAAAGGGAGGAAGAAAGGGCGAGGTCGCAAGGGGAAGGGCAGGAAAAAGAAC
AAGGAAATTTGGACCTCAAGTCCACCTCCTGACTCCGCAGAGAACCAGACCTCCACTGACATCCCCAAGACAGAGACTCCAGCTCCAAAT
CTGCCTCCGACCCCCACGCCTTTGGTCGTCACCTCCACTGTGACTACTGGACTCAATGCCACGATCCTAGAGAGGAGCTTGGACCCTGAC
AGTGGAACCGAGCTGGGGACCCTGGAGACCAAGGCAGCCAGGGAGGATGAAGAAGGAGATGATTCCACCATGGGCCCTGACTTCCGGGCA
GCAGAATATCCATCTCGGACTCAGTTCCAGATCTTTCCTGGTGCTGGAGAGAAAGGAGCAAAAGGAGAGCCCGCAGTGATTGAAAAGGGG
CAGCAGTTTGAGGGACCTCCAGGAGCCCCAGGACCCCAAGGGGTGGTTGGCCCCTCAGGCCCTCCCGGCCCCCCAGGATTCCCTGGCGAC
CCTGGTCCACCGGGCCCTGCTGGCCTCCCAGGAATCCCCGGCATTGATGGGATCCGAGGCCCACCGGGCACTGTGATCATGATGCCGTTC
CAGTTTGCAGGCGGCTCCTTTAAAGGCCCCCCAGTCTCATTCCAGCAGGCCCAGGCTCAGGCAGTTCTGCAGCAGACTCAGCTCTCTATG
AAAGGCCCCCCTGGTCCAGTGGGGCTCACTGGGCGCCCAGGCCCTGTGGGTCTCCCCGGGCATCCAGGTCTGAAAGGAGAGGAGGGAGCA
GAAGGGCCACAGGGTCCCCGAGGCCTGCAGGGACCTCATGGACCCCCTGGCCGAGTGGGCAAGATGGGCCGCCCTGGAGCAGATGGAGCT
CGGGGCCTCCCAGGGGACACTGGACCTAAGGGTGATCGTGGCTTCGATGGCCTCCCTGGGCTGCCTGGTGAGAAGGGCCAAAGGGGTGAC
TTTGGCCATGTGGGGCAACCCGGTCCCCCAGGAGAGGATGGTGAGAGGGGAGCAGAGGGACCTCCAGGGCCCACTGGCCAGGCTGGGGAG
CCGGGTCCACGAGGACTGCTTGGCCCCAGAGGCTCTCCTGGCCCCACGGGTCGCCCGGGTGTGACTGGAATTGATGGTGCTCCTGGTGCC
AAAGGCAATGTGGGTCCTCCAGGAGAACCAGGCCCTCCGGGACAGCAGGGAAACCATGGGTCCCAGGGACTCCCCGGTCCCCAGGGACTC
ATTGGCACTCCTGGGGAGAAGGGTCCCCCTGGAAACCCAGGAATTCCAGGCCTCCCAGGATCCGATGGCCCTCTGGGTCACCCAGGACAT
GAGGGCCCCACGGGAGAGAAAGGGGCTCAGGGTCCACCAGGGTCGGCAGGCCCTCCGGGCTATCCTGGACCTCGGGGAGTGAAGGGCACT
TCAGGCAACCGGGGCCTCCAGGGGGAGAAAGGCGAGAAGGGAGAGGACGGCTTCCCAGGCTTCAAGGGCGATGTGGGGCTCAAAGGTGAT
CAGGGGAAACCCGGAGCTCCAGGTCCCCGGGGAGAGGATGGTCCTGAGGGGCCGAAGGGGCAGGCGGGGCAGGCTGGCGAGGAGGGGCCC
CCAGGCTCAGCTGGGGAGAAGGGCAAGCTTGGGGTGCCAGGCCTCCCAGGTTATCCAGGACGCCCTGGACCTAAGGGATCTATTGGATTT
CCCGGTCCCCTGGGACCCATAGGAGAGAAAGGGAAGTCGGGAAAGACAGGGCAGCCAGGCCTGGAAGGAGAGCGGGGACCACCAGGTTCC
CGTGGAGAGAGGGGGCAACCGGGTGCCACAGGGCAACCAGGCCCCAAGGGCGATGTGGGCCAGGATGGAGCCCCTGGGATCCCTGGAGAA
AAGGGCCTCCCTGGTCTGCAAGGCCCTCCAGGATTCCCTGGGCCAAAGGGCCCCCCTGGTCACCAAGGTAAAGATGGGCGACCAGGGCAC
CCTGGACAGAGAGGAGAACTGGGCTTCCAAGGTCAGACAGGCCCGCCTGGACCAGCTGGTGTCTTAGGCCCTCAGGGAAAGACAGGAGAA
GTGGGACCTCTAGGTGAAAGGGGGCCTCCAGGCCCCCCTGGACCTCCTGGTGAACAAGGTCTTCCTGGCCTGGAAGGCAGAGAGGGGGCC
AAGGGGGAACTGGGACCACCAGGACCCCTTGGGAAAGAAGGGCCAGCTGGACTCAGGGGCTTTCCCGGCCCCAAAGGGGGCCCTGGGGAC
CCGGGACCTACTGGCTTAAAGGGTGATAAGGGCCCCCCAGGGCCCGTGGGGGCCAATGGCTCCCCTGGTGAGCGCGGTCCTTTGGGCCCA
GCAGGAGGCATTGGACTTCCTGGCCAAAGTGGCAGCGAAGGCCCCGTTGGCCCTGCAGGCAAGAAGGGGTCCCGGGGAGAACGTGGCCCC
CCTGGCCCCACTGGCAAAGATGGGATCCCAGGGCCCCTGGGGCCTCTGGGACCCCCTGGAGCTGCTGGGCCTTCTGGCGAGGAAGGGGAC
AAGGGGGATGTGGGTGCCCCCGGACACAAGGGGAGTAAAGGCGATAAAGGAGACGCGGGCCCACCTGGACAACCAGGGATACGGGGTCCT
GCAGGACACCCAGGTCCCCCGGGAGCAGACGGGGCTCAGGGGCGCCGGGGACCCCCAGGCCTCTTTGGGCAGAAAGGAGATGACGGAGTC
AGAGGCTTTGTGGGGGTGATTGGCCCTCCTGGACTGCAGGGGCTGCCAGGCCCTCCGGGAGAGAAAGGGGAGGTCGGAGACGTCGGGTCC
ATGGGTCCCCATGGAGCTCCAGGTCCTCGGGGTCCCCAAGGCCCCACTGGATCAGAGGGCACTCCAGGGCTGCCTGGAGGAGTTGGTCAG
CCAGGCGCCGTGGGTGAGAAGGGTGAGCGAGGGGACGCTGGAGACCCAGGGCCTCCAGGAGCCCCAGGCATCCCGGGGCCCAAGGGAGAC
ATTGGTGAAAAGGGGGACTCAGGCCCATCTGGAGCTGCTGGACCCCCAGGCAAGAAAGGTCCCCCTGGAGAGGATGGAGCCAAAGGGAGC
GTGGGCCCCACGGGGCTGCCCGGAGATCTAGGGCCCCCAGGAGACCCTGGAGTTTCAGGCATAGATGGTTCCCCAGGGGAGAAGGGAGAC
CCTGGTGATGTTGGGGGACCGGGTCCGCCTGGAGCTTCTGGGGAGCCCGGCGCCCCCGGGCCCCCCGGCAAGAGGGGTCCTTCAGGCCAC
ATGGGTCGAGAAGGCAGAGAAGGGGAGAAAGGTGCCAAGGGGGAGCCAGGTCCTGATGGGCCCCCAGGGAGGACGGGTCCAATGGGGGCT
AGAGGGCCCCCTGGACGTGTGGGGCCTGAGGGTCTTCGAGGGATCCCTGGCCCTGTGGGTGAACCAGGCCTCCTGGGAGCCCCTGGACAG
ATGGGCCCTCCTGGCCCCCTGGGGCCCTCTGGCCTCCCAGGGCTGAAGGGAGACACTGGCCCCAAGGGGGAAAAGGGCCACATTGGATTG
ATCGGTCTCATTGGCCCCCCGGGAGAAGCTGGTGAGAAAGGAGATCAGGGGTTGCCAGGCGTGCAGGGACCCCCTGGTCCCAAGGGAGAC
CCTGGTCCCCCTGGTCCCATTGGCTCTCTGGGCCACCCTGGGCCCCCAGGTGTGGCGGGCCCTCTAGGACAGAAAGGCTCAAAAGGGTCT
CCGGGGTCCATGGGCCCCCGTGGAGACACTGGACCTGCAGGCCCACCAGGCCCCCCGGGTGCCCCTGCCGAGCTGCATGGGCTGCGCAGG
CGCCGGCGCTTCGTCCCAGTCCCGCTTCCAGTCGTGGAGGGCGGCCTGGAGGAGGTGCTGGCCTCGCTCACATCGCTGAGCTTGGAGCTG
GAGCAGCTGCGGCGTCCTCCCGGCACTGCGGAGCGCCCGGGCCTCGTGTGCCACGAGCTGCACCGCAACCACCCGCACCTGCCTGATGGG
GAATACTGGATTGACCCCAACCAGGGCTGCGCGCGGGACTCGTTCAGGGTTTTTTGCAACTTCACGGCGGGAGGAGAGACCTGCCTCTAT
CCCGACAAGAAGTTTGAGATCGTGAAATTGGCCTCCTGGTCCAAGGAAAAGCCTGGAGGCTGGTATAGCACATTCCGTCGAGGGAAGAAG
TTCTCCTACGTGGACGCCGACGGGTCCCCAGTGAATGTCGTGCAGCTGAACTTCCTGAAACTGCTGAGTGCCACAGCTCGCCAGAACTTC
ACCTACTCCTGCCAGAATGCAGCTGCCTGGCTGGACGAAGCCACGGGTGACTACAGCCACTCCGCCCGCTTCCTTGGCACCAATGGAGAG
GAGCTGTCTTTCAACCAGACGACAGCAGCCACTGTCAGCGTCCCCCAGGATGGCTGCCGGCTCCGGAAAGGACAGACGAAGACCCTTTTC
GAATTCAGCTCTTCTCGAGCGGGATTTCTGCCCCTGTGGGATGTGGCGGCCACTGACTTTGGCCAGACGAACCAAAAGTTTGGGTTTGAA
CTGGGCCCCGTCTGCTTCAGCAGCTGAGAGTGTCCGGGGTGGGAGGGACCATGAGGGAGCCCCAGAATGGGGTGCATTTGGTGCTGAGGC
TTTGAAGCCACCGTATTTTTCGTTACCTGTGACTATGGAGCCAATGGGATGTGACTTCGCTCATCACGGACAGTCATTCCTTCTCCTTTC
CAGGGTGCTGGGGGCTGGGGTTCCCTGGCCCAAGGGTCCAGCCTCCTCTCACCCCATTCCAGGTGGCATACTGCAGTCTGGCTCTTTCTC
CCCTCCCTCCCCACCCAAGCCTCACCTCCCCACCCCTTGAACCCCCATGCAATGAGCTTCTAACTCAGAGCTGATGAACAAAAGCCCCCC
CACCCCCAATGCCTGCCTCCTCACTCCTCCGTCGCTGCCCTTCACACCTTTTGGTGCTACCCCTCCCCAGAGTTAAGCACTGGATGTCTC
CTGATCCCAGGCTGGGACCCCTACCCCCACCCCCTTTGATCCTTTCTACTTCCACGGTGAAAGGACTGAGGTCGGACTACAGAGGGAAGA
GGGACTTCCCTTGACTGGGTTGTGTTTCTTTTCCTGCCTCAGCCCAGCTCTGCAAATCCCCTCCCCCTGCCCCCCACCTCCCCAGGCTCA
CCTTGCCATGCCAGGTGGTTTGGGGACCAAGATGTTGGGGGGGTGAATCAGGATCCTAATGGTGCTGCCCTATTTATACCTGGGTCTGTA
TTAAAAGGGAAAGTCCCCCCTGTTGTAGATTTCATCTGCTTCCTCCTTAGGGAAGGCTGGGATATGATGAGAGATTCCAGCCCAAGCCTG

>203_203_2_ABCA7-COL5A3_ABCA7_chr19_1059084_ENST00000433129_COL5A3_chr19_10114821_ENST00000264828_length(amino acids)=3368AA_BP=2551
MAFWTQLMLLLWKNFMYRRRQPVQLLVELLWPLFLFFILVAVRHSHPPLEHHECHFPNKPLPSAGTVPWLQGLICNVNNTCFPQLTPGEE
PGRLSNFNDSLVSRLLADARTVLGGASAHRTLAGLGKLIATLRAARSTAQPQPTKQSPLEPPMLDVAELLTSLLRTESLGLALGQAQEPL
HSLLEAAEDLAQELLALRSLVELRALLQRPRGTSGPLELLSEALCSVRGPSSTVGPSLNWYEASDLMELVGQEPESALPDSSLSPACSEL
IGALDSHPLSRLLWRRLKPLILGKLLFAPDTPFTRKLMAQVNRTFEELTLLRDVREVWEMLGPRIFTFMNDSSNVAMLQRLLQMQDEGRR
QPRPGGRDHMEALRSFLDPGSGGYSWQDAHADVGHLVGTLGRVTECLSLDKLEAAPSEAALVSRALQLLAEHRFWAGVVFLGPEDSSDPT
EHPTPDLGPGHVRIKIRMDIDVVTRTNKIRDRFWDPGPAADPLTDLRYVWGGFVYLQDLVERAAVRVLSGANPRAGLYLQQMPYPCYVDD
VFLRVLSRSLPLFLTLAWIYSVTLTVKAVVREKETRLRDTMRAMGLSRAVLWLGWFLSCLGPFLLSAALLVLVLKLGDILPYSHPGVVFL
FLAAFAVATVTQSFLLSAFFSRANLAAACGGLAYFSLYLPYVLCVAWRDRLPAGGRVAASLLSPVAFGFGCESLALLEEQGEGAQWHNVG
TRPTADVFSLAQVSGLLLLDAALYGLATWYLEAVCPGQYGIPEPWNFPFRRSYWCGPRPPKSPAPCPTPLDPKVLVEEAPPGLSPGVSVR
SLEKRFPGSPQPALRGLSLDFYQGHITAFLGHNGAGKTTTLSILSGLFPPSGGSAFILGHDVRSSMAAIRPHLGVCPQYNVLFDMLTVDE
HVWFYGRLKGLSAAVVGPEQDRLLQDVGLVSKQSVQTRHLSGGMQRKLSVAIAFVGGSQVVILDEPTAGVDPASRRGIWELLLKYREGRT
LILSTHHLDEAELLGDRVAVVAGGRLCCCGSPLFLRRHLGSGYYLTLVKARLPLTTNEKADTDMEGSVDTRQEKKNGSQGSRVGTPQLLA
LVQHWVPGARLVEELPHELVLVLPYTGAHDGSFATLFRELDTRLAELRLTGYGISDTSLEEIFLKVVEECAADTDMEDGSCGQHLCTGIA
GLDVTLRLKMPPQETALENGEPAGSAPETDQGSGPDAVGRVQGWALTRQQLQALLLKRFLLARRSRRGLFAQIVLPALFVGLALVFSLIV
PPFGHYPALRLSPTMYGAQVSFFSEDAPGDPGRARLLEALLQEAGLEEPPVQHSSHRFSAPEVPAEVAKVLASGNWTPESPSPACQCSRP
GARRLLPDCPAAAGGPPPPQAVTGSGEVVQNLTGRNLSDFLVKTYPRLVRQGLKTKKWVNEVRYGGFSLGGRDPGLPSGQELGRSVEELW
ALLSPLPGGALDRVLKNLTAWAHSLDAQDSLKIWFNNKGWHSMVAFVNRASNAILRAHLPPGPARHAHSITTLNHPLNLTKEQLSEGALM
ASSVDVLVSICVVFAMSFVPASFTLVLIEERVTRAKHLQLMGGLSPTLYWLGNFLWDMCNYLVPACIVVLIFLAFQQRAYVAPANLPALL
LLLLLYGWSITPLMYPASFFFSVPSTAYVVLTCINLFIGINGSMATFVLELFSDQKLQEVSRILKQVFLIFPHFCLGRGLIDMVRNQAMA
DAFERLGDRQFQSPLRWEVVGKNLLAMVIQGPLFLLFTLLLQHRSQLLPQPRVRSLPLLGEEDEDVARERERVVQGATQGDVLVLRNLTK
VYRGQRMPAVDRLCLGIPPGEGDIQELLISPDPQAAFQACERYLPDCDNLAPAATVAPQGEPETPRPRRKGKGKGRKKGRGRKGKGRKKN
KEIWTSSPPPDSAENQTSTDIPKTETPAPNLPPTPTPLVVTSTVTTGLNATILERSLDPDSGTELGTLETKAAREDEEGDDSTMGPDFRA
AEYPSRTQFQIFPGAGEKGAKGEPAVIEKGQQFEGPPGAPGPQGVVGPSGPPGPPGFPGDPGPPGPAGLPGIPGIDGIRGPPGTVIMMPF
QFAGGSFKGPPVSFQQAQAQAVLQQTQLSMKGPPGPVGLTGRPGPVGLPGHPGLKGEEGAEGPQGPRGLQGPHGPPGRVGKMGRPGADGA
RGLPGDTGPKGDRGFDGLPGLPGEKGQRGDFGHVGQPGPPGEDGERGAEGPPGPTGQAGEPGPRGLLGPRGSPGPTGRPGVTGIDGAPGA
KGNVGPPGEPGPPGQQGNHGSQGLPGPQGLIGTPGEKGPPGNPGIPGLPGSDGPLGHPGHEGPTGEKGAQGPPGSAGPPGYPGPRGVKGT
SGNRGLQGEKGEKGEDGFPGFKGDVGLKGDQGKPGAPGPRGEDGPEGPKGQAGQAGEEGPPGSAGEKGKLGVPGLPGYPGRPGPKGSIGF
PGPLGPIGEKGKSGKTGQPGLEGERGPPGSRGERGQPGATGQPGPKGDVGQDGAPGIPGEKGLPGLQGPPGFPGPKGPPGHQGKDGRPGH
PGQRGELGFQGQTGPPGPAGVLGPQGKTGEVGPLGERGPPGPPGPPGEQGLPGLEGREGAKGELGPPGPLGKEGPAGLRGFPGPKGGPGD
PGPTGLKGDKGPPGPVGANGSPGERGPLGPAGGIGLPGQSGSEGPVGPAGKKGSRGERGPPGPTGKDGIPGPLGPLGPPGAAGPSGEEGD
KGDVGAPGHKGSKGDKGDAGPPGQPGIRGPAGHPGPPGADGAQGRRGPPGLFGQKGDDGVRGFVGVIGPPGLQGLPGPPGEKGEVGDVGS
MGPHGAPGPRGPQGPTGSEGTPGLPGGVGQPGAVGEKGERGDAGDPGPPGAPGIPGPKGDIGEKGDSGPSGAAGPPGKKGPPGEDGAKGS
VGPTGLPGDLGPPGDPGVSGIDGSPGEKGDPGDVGGPGPPGASGEPGAPGPPGKRGPSGHMGREGREGEKGAKGEPGPDGPPGRTGPMGA
RGPPGRVGPEGLRGIPGPVGEPGLLGAPGQMGPPGPLGPSGLPGLKGDTGPKGEKGHIGLIGLIGPPGEAGEKGDQGLPGVQGPPGPKGD
PGPPGPIGSLGHPGPPGVAGPLGQKGSKGSPGSMGPRGDTGPAGPPGPPGAPAELHGLRRRRRFVPVPLPVVEGGLEEVLASLTSLSLEL
EQLRRPPGTAERPGLVCHELHRNHPHLPDGEYWIDPNQGCARDSFRVFCNFTAGGETCLYPDKKFEIVKLASWSKEKPGGWYSTFRRGKK
FSYVDADGSPVNVVQLNFLKLLSATARQNFTYSCQNAAAWLDEATGDYSHSARFLGTNGEELSFNQTTAATVSVPQDGCRLRKGQTKTLF

--------------------------------------------------------------
>203_203_3_ABCA7-COL5A3_ABCA7_chr19_1059084_ENST00000435683_COL5A3_chr19_10114821_ENST00000264828_length(transcript)=10543nt_BP=5049nt
ATGGTCTGCCTGGGAACTGGCCAGAGCGCTGGACCCCTAGTGAGTGTTCAAAATCATTGTCCCCCTTGTGGTCTTTCTCCCCAGGAATCC
CTGGGGTTGGCACTGGGCCAAGCCCAGGAGCCCTTGCACAGCTTGTTGGAGGCCGCTGAGGACCTGGCCCAGGAGCTCCTGGCGCTGCGC
AGCCTGGTGGAGCTTCGGGCACTGCTGCAGAGACCCCGAGGGACCAGCGGCCCCCTGGAGTTGCTGTCAGAGGCCCTCTGCAGTGTCAGG
GGACCTAGCAGCACAGTGGGCCCCTCCCTCAACTGGTACGAGGCTAGTGACCTGATGGAGCTGGTGGGGCAGGAGCCAGAATCCGCCCTG
CCAGACAGCAGCCTGAGCCCCGCCTGCTCGGAGCTGATTGGAGCCCTGGACAGCCACCCGCTGTCCCGCCTGCTCTGGAGACGCCTGAAG
CCTCTGATCCTCGGGAAGCTACTCTTTGCACCAGATACACCTTTTACCCGGAAGCTCATGGCCCAGGTGAACCGGACCTTCGAGGAGCTC
ACCCTGCTGAGGGATGTCCGGGAGGTGTGGGAGATGCTGGGACCCCGGATCTTCACCTTCATGAACGACAGTTCCAATGTGGCCATGCTG
CAGCGGCTCCTGCAGATGCAGGATGAAGGAAGAAGGCAGCCCAGACCTGGAGGCCGGGACCACATGGAGGCCCTGCGATCCTTTCTGGAC
CCTGGGAGCGGTGGCTACAGCTGGCAGGACGCACACGCTGATGTGGGGCACCTGGTGGGCACGCTGGGCCGAGTGACGGAGTGCCTGTCC
TTGGACAAGCTGGAGGCGGCACCCTCAGAGGCAGCCCTGGTGTCGCGGGCCCTGCAACTGCTCGCGGAACATCGATTCTGGGCCGGCGTC
GTCTTCTTGGGACCTGAGGACTCTTCAGACCCCACAGAGCACCCAACCCCAGACCTGGGCCCCGGCCACGTGCGCATCAAAATCCGCATG
GACATTGACGTGGTCACGAGGACCAATAAGATCAGGGACAGGTTTTGGGACCCTGGCCCAGCCGCGGACCCCCTGACCGACCTGCGCTAC
GTGTGGGGCGGCTTCGTGTACCTGCAAGACCTGGTGGAGCGTGCAGCCGTCCGCGTGCTCAGCGGCGCCAACCCCCGGGCCGGCCTCTAC
CTGCAGCAGATGCCCTATCCGTGCTATGTGGACGACGTGTTCCTGCGTGTGCTGAGCCGGTCGCTGCCGCTCTTCCTGACGCTGGCCTGG
ATCTACTCCGTGACACTGACAGTGAAGGCCGTGGTGCGGGAGAAGGAGACGCGGCTGCGGGACACCATGCGCGCCATGGGGCTCAGCCGC
GCGGTGCTCTGGCTAGGCTGGTTCCTCAGCTGCCTCGGGCCCTTCCTGCTCAGCGCCGCACTGCTGGTTCTGGTGCTCAAGCTGGGAGAC
ATCCTCCCCTACAGCCACCCGGGCGTGGTCTTCCTGTTCTTGGCAGCCTTCGCGGTGGCCACGGTGACCCAGAGCTTCCTGCTCAGCGCC
TTCTTCTCCCGCGCCAACCTGGCTGCGGCCTGCGGCGGCCTGGCCTACTTCTCCCTCTACCTGCCCTACGTGCTGTGTGTGGCTTGGCGG
GACCGGCTGCCCGCGGGTGGCCGCGTGGCCGCGAGCCTGCTGTCGCCCGTGGCCTTCGGCTTCGGCTGCGAGAGCCTGGCTCTGCTGGAG
GAGCAGGGCGAGGGCGCGCAGTGGCACAACGTGGGCACCCGGCCTACGGCAGACGTCTTCAGCCTGGCCCAGGTCTCTGGCCTTCTGCTG
CTGGACGCGGCGCTCTACGGCCTCGCCACCTGGTACCTGGAAGCTGTGTGCCCAGGCCAGTACGGGATCCCTGAACCATGGAATTTTCCT
TTTCGGAGGAGCTACTGGTGCGGACCTCGGCCCCCCAAGAGTCCAGCCCCTTGCCCCACCCCGCTGGACCCAAAGGTGCTGGTAGAAGAG
GCACCGCCCGGCCTGAGTCCTGGCGTCTCCGTTCGCAGCCTGGAGAAGCGCTTTCCTGGAAGCCCGCAGCCAGCCCTGCGGGGGCTCAGC
CTGGACTTCTACCAGGGCCACATCACCGCCTTCCTGGGCCACAACGGGGCCGGCAAGACCACCACCCTGTCCATCTTGAGTGGCCTCTTC
CCACCCAGTGGTGGCTCTGCCTTCATCCTGGGCCACGACGTCCGCTCCAGCATGGCCGCCATCCGGCCCCACCTGGGCGTCTGTCCTCAG
TACAACGTGCTGTTTGACATGCTGACCGTGGACGAGCACGTCTGGTTCTATGGGCGGCTGAAGGGTCTGAGTGCCGCTGTAGTGGGCCCC
GAGCAGGACCGTCTGCTGCAGGATGTGGGGCTGGTCTCCAAGCAGAGTGTGCAGACTCGCCACCTCTCTGGTGGGATGCAACGGAAGCTG
TCCGTGGCCATTGCCTTTGTGGGCGGCTCCCAAGTTGTTATCCTGGACGAGCCTACGGCTGGCGTGGATCCTGCTTCCCGCCGCGGTATT
TGGGAGCTGCTGCTCAAATACCGAGAAGGTCGCACGCTGATCCTCTCCACCCACCACCTGGATGAGGCAGAGCTGCTGGGAGACCGTGTG
GCCGTGGTGGCAGGTGGCCGCTTGTGCTGCTGTGGCTCCCCACTCTTCCTGCGCCGTCACCTGGGCTCCGGCTACTACCTGACGCTGGTG
AAGGCCCGCCTGCCCCTGACCACCAATGAGAAGGCTGACACTGACATGGAGGGCAGTGTGGACACCAGGCAGGAAAAGAAGAATGGCAGC
CAGGGCAGCAGAGTCGGCACTCCTCAGCTGCTGGCCCTGGTACAGCACTGGGTGCCCGGGGCACGGCTGGTGGAGGAGCTGCCACACGAG
CTGGTGCTGGTGCTGCCCTACACGGGTGCCCATGACGGCAGCTTCGCCACACTCTTCCGAGAGCTAGACACGCGGCTGGCGGAGCTGAGG
CTCACTGGCTACGGGATCTCCGACACCAGCCTCGAGGAGATCTTCCTGAAGGTGGTGGAGGAGTGTGCTGCGGACACAGATATGGAGGAT
GGCAGCTGCGGGCAGCACCTATGCACAGGCATTGCTGGCCTAGACGTAACCCTACGGCTCAAGATGCCGCCACAGGAGACAGCGCTGGAG
AACGGGGAACCAGCTGGGTCAGCCCCAGAGACTGACCAGGGCTCTGGGCCAGACGCCGTGGGCCGGGTACAGGGCTGGGCACTGACCCGC
CAGCAGCTCCAGGCCCTGCTTCTCAAGCGCTTTCTGCTTGCCCGCCGCAGCCGCCGCGGCCTGTTCGCCCAGATCGTGCTGCCTGCCCTC
TTTGTGGGCCTGGCCCTCGTGTTCAGCCTCATCGTGCCTCCTTTCGGGCACTACCCGGCTCTGCGGCTCAGTCCCACCATGTACGGTGCT
CAGGTGTCCTTCTTCAGTGAGGACGCCCCAGGGGACCCTGGACGTGCCCGGCTGCTCGAGGCGCTGCTGCAGGAGGCAGGACTGGAGGAG
CCCCCAGTGCAGCATAGCTCCCACAGGTTCTCGGCACCAGAAGTTCCTGCTGAAGTGGCCAAGGTCTTGGCCAGTGGCAACTGGACCCCA
GAGTCTCCATCCCCAGCCTGCCAGTGTAGCCGGCCCGGTGCCCGGCGCCTGCTGCCCGACTGCCCGGCTGCAGCTGGTGGTCCCCCTCCG
CCCCAGGCAGTGACCGGCTCTGGGGAAGTGGTTCAGAACCTGACAGGCCGGAACCTGTCTGACTTCCTGGTCAAGACCTACCCGCGCCTG
GTGCGCCAGGGCCTGAAGACTAAGAAGTGGGTGAATGAGGTCAGATACGGAGGCTTCTCGCTGGGGGGCCGAGACCCAGGCCTGCCCTCG
GGCCAAGAGTTGGGCCGCTCAGTGGAGGAGTTGTGGGCGCTGCTGAGTCCCCTGCCTGGCGGGGCCCTCGACCGTGTCCTGAAAAACCTC
ACAGCCTGGGCTCACAGCCTGGATGCTCAGGACAGTCTCAAGATCTGGTTCAACAACAAAGGCTGGCACTCCATGGTGGCCTTTGTCAAC
CGAGCCAGCAACGCAATCCTCCGTGCTCACCTGCCCCCAGGCCCGGCCCGCCACGCCCACAGCATCACCACACTCAACCACCCCTTGAAC
CTCACCAAGGAGCAGCTGTCTGAGGGTGCACTGATGGCCTCCTCGGTGGACGTCCTCGTCTCCATCTGTGTGGTCTTTGCCATGTCCTTT
GTCCCGGCCAGCTTCACTCTTGTCCTCATTGAGGAGCGAGTCACCCGAGCCAAGCACCTGCAGCTCATGGGGGGCCTGTCCCCCACCCTC
TACTGGCTTGGCAACTTTCTCTGGGACATGTGTAACTACTTGGTGCCAGCATGCATCGTGGTGCTCATCTTTCTGGCCTTCCAGCAGAGG
GCATATGTGGCCCCTGCCAACCTGCCTGCTCTCCTGCTGTTGCTACTACTGTATGGCTGGTCGATCACACCGCTCATGTACCCAGCCTCC
TTCTTCTTCTCCGTGCCCAGCACAGCCTATGTGGTGCTCACCTGCATAAACCTCTTTATTGGCATCAATGGAAGCATGGCCACCTTTGTG
CTTGAGCTCTTCTCTGATCAGAAGCTGCAGGAGGTGAGCCGGATCTTGAAACAGGTCTTCCTTATCTTCCCCCACTTCTGCTTGGGCCGG
GGGCTCATTGACATGGTGCGGAACCAGGCCATGGCTGATGCCTTTGAGCGCTTGGGAGACAGGCAGTTCCAGTCACCCCTGCGCTGGGAG
GTGGTCGGCAAGAACCTCTTGGCCATGGTGATACAGGGGCCCCTCTTCCTTCTCTTCACACTACTGCTGCAGCACCGAAGCCAACTCCTG
CCACAGCCCAGGGTGAGGTCTCTGCCACTCCTGGGAGAGGAGGACGAGGATGTAGCCCGTGAACGGGAGCGGGTGGTCCAAGGAGCCACC
CAGGGGGATGTGTTGGTGCTGAGGAACTTGACCAAGGTATACCGTGGGCAGAGGATGCCAGCTGTTGACCGCTTGTGCCTGGGGATTCCC
CCTGGTGAGGGAGACATTCAGGAGCTGCTGATAAGCCCAGATCCTCAGGCTGCCTTCCAGGCTTGTGAGCGGTACCTCCCCGACTGTGAC
AACCTGGCACCGGCAGCCACAGTGGCTCCCCAGGGTGAACCAGAAACCCCTCGTCCTCGGCGGAAGGGGAAGGGAAAAGGGAGGAAGAAA
GGGCGAGGTCGCAAGGGGAAGGGCAGGAAAAAGAACAAGGAAATTTGGACCTCAAGTCCACCTCCTGACTCCGCAGAGAACCAGACCTCC
ACTGACATCCCCAAGACAGAGACTCCAGCTCCAAATCTGCCTCCGACCCCCACGCCTTTGGTCGTCACCTCCACTGTGACTACTGGACTC
AATGCCACGATCCTAGAGAGGAGCTTGGACCCTGACAGTGGAACCGAGCTGGGGACCCTGGAGACCAAGGCAGCCAGGGAGGATGAAGAA
GGAGATGATTCCACCATGGGCCCTGACTTCCGGGCAGCAGAATATCCATCTCGGACTCAGTTCCAGATCTTTCCTGGTGCTGGAGAGAAA
GGAGCAAAAGGAGAGCCCGCAGTGATTGAAAAGGGGCAGCAGTTTGAGGGACCTCCAGGAGCCCCAGGACCCCAAGGGGTGGTTGGCCCC
TCAGGCCCTCCCGGCCCCCCAGGATTCCCTGGCGACCCTGGTCCACCGGGCCCTGCTGGCCTCCCAGGAATCCCCGGCATTGATGGGATC
CGAGGCCCACCGGGCACTGTGATCATGATGCCGTTCCAGTTTGCAGGCGGCTCCTTTAAAGGCCCCCCAGTCTCATTCCAGCAGGCCCAG
GCTCAGGCAGTTCTGCAGCAGACTCAGCTCTCTATGAAAGGCCCCCCTGGTCCAGTGGGGCTCACTGGGCGCCCAGGCCCTGTGGGTCTC
CCCGGGCATCCAGGTCTGAAAGGAGAGGAGGGAGCAGAAGGGCCACAGGGTCCCCGAGGCCTGCAGGGACCTCATGGACCCCCTGGCCGA
GTGGGCAAGATGGGCCGCCCTGGAGCAGATGGAGCTCGGGGCCTCCCAGGGGACACTGGACCTAAGGGTGATCGTGGCTTCGATGGCCTC
CCTGGGCTGCCTGGTGAGAAGGGCCAAAGGGGTGACTTTGGCCATGTGGGGCAACCCGGTCCCCCAGGAGAGGATGGTGAGAGGGGAGCA
GAGGGACCTCCAGGGCCCACTGGCCAGGCTGGGGAGCCGGGTCCACGAGGACTGCTTGGCCCCAGAGGCTCTCCTGGCCCCACGGGTCGC
CCGGGTGTGACTGGAATTGATGGTGCTCCTGGTGCCAAAGGCAATGTGGGTCCTCCAGGAGAACCAGGCCCTCCGGGACAGCAGGGAAAC
CATGGGTCCCAGGGACTCCCCGGTCCCCAGGGACTCATTGGCACTCCTGGGGAGAAGGGTCCCCCTGGAAACCCAGGAATTCCAGGCCTC
CCAGGATCCGATGGCCCTCTGGGTCACCCAGGACATGAGGGCCCCACGGGAGAGAAAGGGGCTCAGGGTCCACCAGGGTCGGCAGGCCCT
CCGGGCTATCCTGGACCTCGGGGAGTGAAGGGCACTTCAGGCAACCGGGGCCTCCAGGGGGAGAAAGGCGAGAAGGGAGAGGACGGCTTC
CCAGGCTTCAAGGGCGATGTGGGGCTCAAAGGTGATCAGGGGAAACCCGGAGCTCCAGGTCCCCGGGGAGAGGATGGTCCTGAGGGGCCG
AAGGGGCAGGCGGGGCAGGCTGGCGAGGAGGGGCCCCCAGGCTCAGCTGGGGAGAAGGGCAAGCTTGGGGTGCCAGGCCTCCCAGGTTAT
CCAGGACGCCCTGGACCTAAGGGATCTATTGGATTTCCCGGTCCCCTGGGACCCATAGGAGAGAAAGGGAAGTCGGGAAAGACAGGGCAG
CCAGGCCTGGAAGGAGAGCGGGGACCACCAGGTTCCCGTGGAGAGAGGGGGCAACCGGGTGCCACAGGGCAACCAGGCCCCAAGGGCGAT
GTGGGCCAGGATGGAGCCCCTGGGATCCCTGGAGAAAAGGGCCTCCCTGGTCTGCAAGGCCCTCCAGGATTCCCTGGGCCAAAGGGCCCC
CCTGGTCACCAAGGTAAAGATGGGCGACCAGGGCACCCTGGACAGAGAGGAGAACTGGGCTTCCAAGGTCAGACAGGCCCGCCTGGACCA
GCTGGTGTCTTAGGCCCTCAGGGAAAGACAGGAGAAGTGGGACCTCTAGGTGAAAGGGGGCCTCCAGGCCCCCCTGGACCTCCTGGTGAA
CAAGGTCTTCCTGGCCTGGAAGGCAGAGAGGGGGCCAAGGGGGAACTGGGACCACCAGGACCCCTTGGGAAAGAAGGGCCAGCTGGACTC
AGGGGCTTTCCCGGCCCCAAAGGGGGCCCTGGGGACCCGGGACCTACTGGCTTAAAGGGTGATAAGGGCCCCCCAGGGCCCGTGGGGGCC
AATGGCTCCCCTGGTGAGCGCGGTCCTTTGGGCCCAGCAGGAGGCATTGGACTTCCTGGCCAAAGTGGCAGCGAAGGCCCCGTTGGCCCT
GCAGGCAAGAAGGGGTCCCGGGGAGAACGTGGCCCCCCTGGCCCCACTGGCAAAGATGGGATCCCAGGGCCCCTGGGGCCTCTGGGACCC
CCTGGAGCTGCTGGGCCTTCTGGCGAGGAAGGGGACAAGGGGGATGTGGGTGCCCCCGGACACAAGGGGAGTAAAGGCGATAAAGGAGAC
GCGGGCCCACCTGGACAACCAGGGATACGGGGTCCTGCAGGACACCCAGGTCCCCCGGGAGCAGACGGGGCTCAGGGGCGCCGGGGACCC
CCAGGCCTCTTTGGGCAGAAAGGAGATGACGGAGTCAGAGGCTTTGTGGGGGTGATTGGCCCTCCTGGACTGCAGGGGCTGCCAGGCCCT
CCGGGAGAGAAAGGGGAGGTCGGAGACGTCGGGTCCATGGGTCCCCATGGAGCTCCAGGTCCTCGGGGTCCCCAAGGCCCCACTGGATCA
GAGGGCACTCCAGGGCTGCCTGGAGGAGTTGGTCAGCCAGGCGCCGTGGGTGAGAAGGGTGAGCGAGGGGACGCTGGAGACCCAGGGCCT
CCAGGAGCCCCAGGCATCCCGGGGCCCAAGGGAGACATTGGTGAAAAGGGGGACTCAGGCCCATCTGGAGCTGCTGGACCCCCAGGCAAG
AAAGGTCCCCCTGGAGAGGATGGAGCCAAAGGGAGCGTGGGCCCCACGGGGCTGCCCGGAGATCTAGGGCCCCCAGGAGACCCTGGAGTT
TCAGGCATAGATGGTTCCCCAGGGGAGAAGGGAGACCCTGGTGATGTTGGGGGACCGGGTCCGCCTGGAGCTTCTGGGGAGCCCGGCGCC
CCCGGGCCCCCCGGCAAGAGGGGTCCTTCAGGCCACATGGGTCGAGAAGGCAGAGAAGGGGAGAAAGGTGCCAAGGGGGAGCCAGGTCCT
GATGGGCCCCCAGGGAGGACGGGTCCAATGGGGGCTAGAGGGCCCCCTGGACGTGTGGGGCCTGAGGGTCTTCGAGGGATCCCTGGCCCT
GTGGGTGAACCAGGCCTCCTGGGAGCCCCTGGACAGATGGGCCCTCCTGGCCCCCTGGGGCCCTCTGGCCTCCCAGGGCTGAAGGGAGAC
ACTGGCCCCAAGGGGGAAAAGGGCCACATTGGATTGATCGGTCTCATTGGCCCCCCGGGAGAAGCTGGTGAGAAAGGAGATCAGGGGTTG
CCAGGCGTGCAGGGACCCCCTGGTCCCAAGGGAGACCCTGGTCCCCCTGGTCCCATTGGCTCTCTGGGCCACCCTGGGCCCCCAGGTGTG
GCGGGCCCTCTAGGACAGAAAGGCTCAAAAGGGTCTCCGGGGTCCATGGGCCCCCGTGGAGACACTGGACCTGCAGGCCCACCAGGCCCC
CCGGGTGCCCCTGCCGAGCTGCATGGGCTGCGCAGGCGCCGGCGCTTCGTCCCAGTCCCGCTTCCAGTCGTGGAGGGCGGCCTGGAGGAG
GTGCTGGCCTCGCTCACATCGCTGAGCTTGGAGCTGGAGCAGCTGCGGCGTCCTCCCGGCACTGCGGAGCGCCCGGGCCTCGTGTGCCAC
GAGCTGCACCGCAACCACCCGCACCTGCCTGATGGGGAATACTGGATTGACCCCAACCAGGGCTGCGCGCGGGACTCGTTCAGGGTTTTT
TGCAACTTCACGGCGGGAGGAGAGACCTGCCTCTATCCCGACAAGAAGTTTGAGATCGTGAAATTGGCCTCCTGGTCCAAGGAAAAGCCT
GGAGGCTGGTATAGCACATTCCGTCGAGGGAAGAAGTTCTCCTACGTGGACGCCGACGGGTCCCCAGTGAATGTCGTGCAGCTGAACTTC
CTGAAACTGCTGAGTGCCACAGCTCGCCAGAACTTCACCTACTCCTGCCAGAATGCAGCTGCCTGGCTGGACGAAGCCACGGGTGACTAC
AGCCACTCCGCCCGCTTCCTTGGCACCAATGGAGAGGAGCTGTCTTTCAACCAGACGACAGCAGCCACTGTCAGCGTCCCCCAGGATGGC
TGCCGGCTCCGGAAAGGACAGACGAAGACCCTTTTCGAATTCAGCTCTTCTCGAGCGGGATTTCTGCCCCTGTGGGATGTGGCGGCCACT
GACTTTGGCCAGACGAACCAAAAGTTTGGGTTTGAACTGGGCCCCGTCTGCTTCAGCAGCTGAGAGTGTCCGGGGTGGGAGGGACCATGA
GGGAGCCCCAGAATGGGGTGCATTTGGTGCTGAGGCTTTGAAGCCACCGTATTTTTCGTTACCTGTGACTATGGAGCCAATGGGATGTGA
CTTCGCTCATCACGGACAGTCATTCCTTCTCCTTTCCAGGGTGCTGGGGGCTGGGGTTCCCTGGCCCAAGGGTCCAGCCTCCTCTCACCC
CATTCCAGGTGGCATACTGCAGTCTGGCTCTTTCTCCCCTCCCTCCCCACCCAAGCCTCACCTCCCCACCCCTTGAACCCCCATGCAATG
AGCTTCTAACTCAGAGCTGATGAACAAAAGCCCCCCCACCCCCAATGCCTGCCTCCTCACTCCTCCGTCGCTGCCCTTCACACCTTTTGG
TGCTACCCCTCCCCAGAGTTAAGCACTGGATGTCTCCTGATCCCAGGCTGGGACCCCTACCCCCACCCCCTTTGATCCTTTCTACTTCCA
CGGTGAAAGGACTGAGGTCGGACTACAGAGGGAAGAGGGACTTCCCTTGACTGGGTTGTGTTTCTTTTCCTGCCTCAGCCCAGCTCTGCA
AATCCCCTCCCCCTGCCCCCCACCTCCCCAGGCTCACCTTGCCATGCCAGGTGGTTTGGGGACCAAGATGTTGGGGGGGTGAATCAGGAT
CCTAATGGTGCTGCCCTATTTATACCTGGGTCTGTATTAAAAGGGAAAGTCCCCCCTGTTGTAGATTTCATCTGCTTCCTCCTTAGGGAA
GGCTGGGATATGATGAGAGATTCCAGCCCAAGCCTGGCCCCCCACCGCCAGGCCATAGGGCATAATTTGCATCTCAAATCTGAGAATAAA

>203_203_3_ABCA7-COL5A3_ABCA7_chr19_1059084_ENST00000435683_COL5A3_chr19_10114821_ENST00000264828_length(amino acids)=3230AA_BP=2413
MVCLGTGQSAGPLVSVQNHCPPCGLSPQESLGLALGQAQEPLHSLLEAAEDLAQELLALRSLVELRALLQRPRGTSGPLELLSEALCSVR
GPSSTVGPSLNWYEASDLMELVGQEPESALPDSSLSPACSELIGALDSHPLSRLLWRRLKPLILGKLLFAPDTPFTRKLMAQVNRTFEEL
TLLRDVREVWEMLGPRIFTFMNDSSNVAMLQRLLQMQDEGRRQPRPGGRDHMEALRSFLDPGSGGYSWQDAHADVGHLVGTLGRVTECLS
LDKLEAAPSEAALVSRALQLLAEHRFWAGVVFLGPEDSSDPTEHPTPDLGPGHVRIKIRMDIDVVTRTNKIRDRFWDPGPAADPLTDLRY
VWGGFVYLQDLVERAAVRVLSGANPRAGLYLQQMPYPCYVDDVFLRVLSRSLPLFLTLAWIYSVTLTVKAVVREKETRLRDTMRAMGLSR
AVLWLGWFLSCLGPFLLSAALLVLVLKLGDILPYSHPGVVFLFLAAFAVATVTQSFLLSAFFSRANLAAACGGLAYFSLYLPYVLCVAWR
DRLPAGGRVAASLLSPVAFGFGCESLALLEEQGEGAQWHNVGTRPTADVFSLAQVSGLLLLDAALYGLATWYLEAVCPGQYGIPEPWNFP
FRRSYWCGPRPPKSPAPCPTPLDPKVLVEEAPPGLSPGVSVRSLEKRFPGSPQPALRGLSLDFYQGHITAFLGHNGAGKTTTLSILSGLF
PPSGGSAFILGHDVRSSMAAIRPHLGVCPQYNVLFDMLTVDEHVWFYGRLKGLSAAVVGPEQDRLLQDVGLVSKQSVQTRHLSGGMQRKL
SVAIAFVGGSQVVILDEPTAGVDPASRRGIWELLLKYREGRTLILSTHHLDEAELLGDRVAVVAGGRLCCCGSPLFLRRHLGSGYYLTLV
KARLPLTTNEKADTDMEGSVDTRQEKKNGSQGSRVGTPQLLALVQHWVPGARLVEELPHELVLVLPYTGAHDGSFATLFRELDTRLAELR
LTGYGISDTSLEEIFLKVVEECAADTDMEDGSCGQHLCTGIAGLDVTLRLKMPPQETALENGEPAGSAPETDQGSGPDAVGRVQGWALTR
QQLQALLLKRFLLARRSRRGLFAQIVLPALFVGLALVFSLIVPPFGHYPALRLSPTMYGAQVSFFSEDAPGDPGRARLLEALLQEAGLEE
PPVQHSSHRFSAPEVPAEVAKVLASGNWTPESPSPACQCSRPGARRLLPDCPAAAGGPPPPQAVTGSGEVVQNLTGRNLSDFLVKTYPRL
VRQGLKTKKWVNEVRYGGFSLGGRDPGLPSGQELGRSVEELWALLSPLPGGALDRVLKNLTAWAHSLDAQDSLKIWFNNKGWHSMVAFVN
RASNAILRAHLPPGPARHAHSITTLNHPLNLTKEQLSEGALMASSVDVLVSICVVFAMSFVPASFTLVLIEERVTRAKHLQLMGGLSPTL
YWLGNFLWDMCNYLVPACIVVLIFLAFQQRAYVAPANLPALLLLLLLYGWSITPLMYPASFFFSVPSTAYVVLTCINLFIGINGSMATFV
LELFSDQKLQEVSRILKQVFLIFPHFCLGRGLIDMVRNQAMADAFERLGDRQFQSPLRWEVVGKNLLAMVIQGPLFLLFTLLLQHRSQLL
PQPRVRSLPLLGEEDEDVARERERVVQGATQGDVLVLRNLTKVYRGQRMPAVDRLCLGIPPGEGDIQELLISPDPQAAFQACERYLPDCD
NLAPAATVAPQGEPETPRPRRKGKGKGRKKGRGRKGKGRKKNKEIWTSSPPPDSAENQTSTDIPKTETPAPNLPPTPTPLVVTSTVTTGL
NATILERSLDPDSGTELGTLETKAAREDEEGDDSTMGPDFRAAEYPSRTQFQIFPGAGEKGAKGEPAVIEKGQQFEGPPGAPGPQGVVGP
SGPPGPPGFPGDPGPPGPAGLPGIPGIDGIRGPPGTVIMMPFQFAGGSFKGPPVSFQQAQAQAVLQQTQLSMKGPPGPVGLTGRPGPVGL
PGHPGLKGEEGAEGPQGPRGLQGPHGPPGRVGKMGRPGADGARGLPGDTGPKGDRGFDGLPGLPGEKGQRGDFGHVGQPGPPGEDGERGA
EGPPGPTGQAGEPGPRGLLGPRGSPGPTGRPGVTGIDGAPGAKGNVGPPGEPGPPGQQGNHGSQGLPGPQGLIGTPGEKGPPGNPGIPGL
PGSDGPLGHPGHEGPTGEKGAQGPPGSAGPPGYPGPRGVKGTSGNRGLQGEKGEKGEDGFPGFKGDVGLKGDQGKPGAPGPRGEDGPEGP
KGQAGQAGEEGPPGSAGEKGKLGVPGLPGYPGRPGPKGSIGFPGPLGPIGEKGKSGKTGQPGLEGERGPPGSRGERGQPGATGQPGPKGD
VGQDGAPGIPGEKGLPGLQGPPGFPGPKGPPGHQGKDGRPGHPGQRGELGFQGQTGPPGPAGVLGPQGKTGEVGPLGERGPPGPPGPPGE
QGLPGLEGREGAKGELGPPGPLGKEGPAGLRGFPGPKGGPGDPGPTGLKGDKGPPGPVGANGSPGERGPLGPAGGIGLPGQSGSEGPVGP
AGKKGSRGERGPPGPTGKDGIPGPLGPLGPPGAAGPSGEEGDKGDVGAPGHKGSKGDKGDAGPPGQPGIRGPAGHPGPPGADGAQGRRGP
PGLFGQKGDDGVRGFVGVIGPPGLQGLPGPPGEKGEVGDVGSMGPHGAPGPRGPQGPTGSEGTPGLPGGVGQPGAVGEKGERGDAGDPGP
PGAPGIPGPKGDIGEKGDSGPSGAAGPPGKKGPPGEDGAKGSVGPTGLPGDLGPPGDPGVSGIDGSPGEKGDPGDVGGPGPPGASGEPGA
PGPPGKRGPSGHMGREGREGEKGAKGEPGPDGPPGRTGPMGARGPPGRVGPEGLRGIPGPVGEPGLLGAPGQMGPPGPLGPSGLPGLKGD
TGPKGEKGHIGLIGLIGPPGEAGEKGDQGLPGVQGPPGPKGDPGPPGPIGSLGHPGPPGVAGPLGQKGSKGSPGSMGPRGDTGPAGPPGP
PGAPAELHGLRRRRRFVPVPLPVVEGGLEEVLASLTSLSLELEQLRRPPGTAERPGLVCHELHRNHPHLPDGEYWIDPNQGCARDSFRVF
CNFTAGGETCLYPDKKFEIVKLASWSKEKPGGWYSTFRRGKKFSYVDADGSPVNVVQLNFLKLLSATARQNFTYSCQNAAAWLDEATGDY

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Fusion Gene PPI Analysis for ABCA7-COL5A3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ABCA7-COL5A3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ABCA7-COL5A3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneABCA7C0276496Familial Alzheimer Disease (FAD)3CTD_human;ORPHANET
HgeneABCA7C4282179ALZHEIMER DISEASE 9, SUSCEPTIBILITY TO3UNIPROT
HgeneABCA7C0002395Alzheimer's Disease2CTD_human
HgeneABCA7C0011265Presenile dementia2CTD_human
HgeneABCA7C0494463Alzheimer Disease, Late Onset2CTD_human
HgeneABCA7C0546126Acute Confusional Senile Dementia2CTD_human
HgeneABCA7C0750900Alzheimer's Disease, Focal Onset2CTD_human
HgeneABCA7C0750901Alzheimer Disease, Early Onset2CTD_human
HgeneABCA7C0235874Disease Exacerbation1CTD_human
TgeneC0033578Prostatic Neoplasms1CTD_human
TgeneC0376358Malignant neoplasm of prostate1CTD_human