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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:RNU6-2-NGLY1 (FusionGDB2 ID:HG103625684TG55768)

Fusion Gene Summary for RNU6-2-NGLY1

check button Fusion gene summary
Fusion gene informationFusion gene name: RNU6-2-NGLY1
Fusion gene ID: hg103625684tg55768
HgeneTgene
Gene symbol

RNU6-2

NGLY1

Gene ID

103625684

55768

Gene nameRNA, U6 small nuclear 2N-glycanase 1
SynonymsU6-2CDDG|CDG1V|PNG-1|PNG1|PNGase
Cytomap('RNU6-2')('NGLY1')

19p13.3

3p24.2

Type of genesnRNAprotein-coding
Description-peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidasehPNGasepeptide:N-glycanase
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000384627, 
Fusion gene scores* DoF score1 X 1 X 1=16 X 5 X 4=120
# samples 16
** MAII scorelog2(1/1*10)=3.32192809488736log2(6/120*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: RNU6-2 [Title/Abstract] AND NGLY1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointRNU6-2(1021628)-NGLY1(25820156), # samples:1
Anticipated loss of major functional domain due to fusion event.RNU6-2-NGLY1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
RNU6-2-NGLY1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneNGLY1

GO:0006516

glycoprotein catabolic process

15358861

TgeneNGLY1

GO:0006517

protein deglycosylation

28826503


check buttonFusion gene breakpoints across RNU6-2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across NGLY1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand


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Fusion Gene ORF analysis for RNU6-2-NGLY1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000384627ENST00000428257RNU6-2chr191021628+NGLY1chr325820156-0.085361550.9146384
ENST00000384627ENST00000280700RNU6-2chr191021628+NGLY1chr325820156-0.158102240.8418978
ENST00000384627ENST00000396649RNU6-2chr191021628+NGLY1chr325820156-0.190622270.80937773
ENST00000384627ENST00000417874RNU6-2chr191021628+NGLY1chr325820156-0.219197170.7808028

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Fusion Genomic Features for RNU6-2-NGLY1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

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Fusion Protein Features for RNU6-2-NGLY1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:1021628/chr3:25820156)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneNGLY1chr19:1021628chr3:25820156ENST0000028070001230_910655.0DomainNote=PUB
TgeneNGLY1chr19:1021628chr3:25820156ENST00000280700012454_6540655.0DomainPAW
TgeneNGLY1chr19:1021628chr3:25820156ENST0000039664901130_910559.0DomainNote=PUB
TgeneNGLY1chr19:1021628chr3:25820156ENST00000396649011454_6540559.0DomainPAW
TgeneNGLY1chr19:1021628chr3:25820156ENST0000041787401230_910613.0DomainNote=PUB
TgeneNGLY1chr19:1021628chr3:25820156ENST00000417874012454_6540613.0DomainPAW
TgeneNGLY1chr19:1021628chr3:25820156ENST0000042825701230_910637.0DomainNote=PUB
TgeneNGLY1chr19:1021628chr3:25820156ENST00000428257012454_6540637.0DomainPAW

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for RNU6-2-NGLY1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>75233_75233_1_RNU6-2-NGLY1_RNU6-2_chr19_1021628_ENST00000384627_NGLY1_chr3_25820156_ENST00000280700_length(transcript)=2265nt_BP=107nt
GTGCTCGCTTCGGCAGCACATATACTAAAATTGGAACGATACAGAGAAGATTAGCATGGCCCCTGCGCAAGGATGACACGCAAATTCGTG
AAGCGTTCCATATTTTTATAACAGTCTTCACTCCTATGCTGATTTTTCTGGTGCCACTGAAGTTATTTTGGAAGCAGAATTAAGCAGAGG
AGATGGTGATGTCGCTTGGCAACACACCCAGCTGTTTAGACAAAGCTTAAATGACCATGAAGAAAATTGTTTGGAGATAATTATAAAATT
CAGTGACCTTTGAGAACCTGAACATTATAGAAAAGCTGGCAATAATCAAGGACTTACTGAAGTAGTCTGTTGGTTCAGTGCATGCTTAGT
TGGCAGTTACCACCCTGTGCTAGCATATTTCTTTTGCTAGCTATCCATCATGTAACCCTCATGAAAATTATCTTTATACGTGGACTATAA
TAAAATATTGAATTAAAACCTTTCTTCCATATGTGACTATAATTTGGAGTAAAGTCTTGTTGACTCAATATGGGATTTTAATCTAAAACT
GTAAGTATGGTTTTAAAAGTTAAATAATGATATTCATGATTAAATGCTATTCATGATTATGATAAAATCTTGGGCTTATGATAGTAATTT
GTATATTTGGCCCGAAAGGAAGGATCATCTTTTGCTTATATTTCCTGGAAGTTTGAGTGTGGGTCAGTTGGCCTAAAAGTAGATAGCATT
TCTATTAGAACAAGTAGTCAAACTTTTCAGACTGGAACAGTAGAATGGAAATTGCGATCTGATACAGCACAAGTAGAACTGACAGGCGAG
AAAAGAAACCTTGTTTATTCCCTGTGAAAATGAGAAGATTTCTAAACAGCTCCACCTTTGTTACAATATTGTGAAAGATCGTTATGTTCG
AGTTTCAAATAACAATCAAACCATTTCTGGATGGGAGAATGGCGTGTGGAAAATGGAATCTATATTCAGAAAAGTTGAAACAGACTGGCA
CATGAGGCAACTGTTTTTGTCAGAAAACAGAAGGAAAGAACTTCTCCAGAGGATAATTGTGGAGCTTGTTGAATTTATATCTCCCAAAAC
CCCTAAACCTGGAGAACTTGGGGGAAGAATATCTGGGTCAGTGGCTTGGAGAGTAGCCCGAGGTGAAATGGGTCTACAGGTAGTTGATGT
CACTTGGCGATATTCCTGCAAACATGAAGAGGTGATTGCCAGAAGAACTAAGGTTAAAGAAGCATTACTTCGAGACACTATTAATGGGCT
TAATAAGCAGACCATGTCTGGACAGAAGTCTATTCTCCTTCTCAGCAGCGGTGGCTGCACTGTGATGCATGTGAAGATGTCTGTGACAAG
CCACTCCTTTATGAAATAGGATGGGGCAAGAAGCTTTCCTATGTCATAGCATTTTCAAAAGATGAGATATAATAACCCTGAGAAACTTTT
GGAAACAAGATGTGGACGGTGTGGCGAGTGGGCCAATTGTTTTACACTGTGCTGCCGAGCTGTAGGGTTTGAAGCTCGCTATGTTTGGGA
TTACACAGGTATCAATATAAGTGATGAGGATTTTCTTTTGCTGGAGCTTTTGCACTGGTTTAAGGAAGAATTTTTTCACTGGGTGAATAA
CGTTTTGTGCAGCAAATGTGGTGGACAGACTAGGTCTAGAGATAGATCATTACTGCCCAGTGATGATGAGCTGAAGTGGGGTGCAAAGGA
AGTGGAAGATCATTACTGTGATGCCTGCCAGTTCAGCAATCGATTCCCAAGGTTGCTGCTGACTCAGCCATTCTAGAAGTTCTTCAGTCC
AACATTCAGCATGTGCTGGTCTATGAAAATCCTGCTCTTCAGGAGAAAGCGTTGGCTTGTATTCCGGTCCAAGAACTAAAAAGGAAATCA
CAAGAAAAGTTATCGAGAGCTAGAAAATTGGATAAAGGGAGAAACACATCTCATCTTTCCTAAAAAAGCTTCAGTGGAGCAGCTGCAAAA
AATTCGTGACCTGATTGCCATAGAGAGAAGTAGCAGACTGGATGGCTCAAATAAGAGCCACAAAGTAAAGTCATCTCAGCAACCTGCAGC
CAGTACCCAGCTTCCTACAACACCATCTTCAAATCCCAGTGGGTTAAACCAGCACACAAGGAACCGTCAAGGGCAGTCATCAGATCCACC
ATCTGCTTCAACGGATCCATCCGGATTGGAAACACAGCCTTTTCTACTAGACTCTTGCCTGTCAGAGGAGCTGTTGAATGTTTATTTGAA

>75233_75233_1_RNU6-2-NGLY1_RNU6-2_chr19_1021628_ENST00000384627_NGLY1_chr3_25820156_ENST00000280700_length(amino acids)=182AA_BP=
MFIPCENEKISKQLHLCYNIVKDRYVRVSNNNQTISGWENGVWKMESIFRKVETDWHMRQLFLSENRRKELLQRIIVELVEFISPKTPKP
GELGGRISGSVAWRVARGEMGLQVVDVTWRYSCKHEEVIARRTKVKEALLRDTINGLNKQTMSGQKSILLLSSGGCTVMHVKMSVTSHSF

--------------------------------------------------------------
>75233_75233_2_RNU6-2-NGLY1_RNU6-2_chr19_1021628_ENST00000384627_NGLY1_chr3_25820156_ENST00000396649_length(transcript)=1929nt_BP=107nt
GTGCTCGCTTCGGCAGCACATATACTAAAATTGGAACGATACAGAGAAGATTAGCATGGCCCCTGCGCAAGGATGACACGCAAATTCGTG
AAGCGTTCCATATTTTTATAACAGTCTTCACTCCTATGCTGATTTTTCTGGTGCCACTGAAGTTATTTTGGAAGCAGAATTAAGCAGAGG
AGATGGTGATGTCGCTTGGCAACACACCCAGCTGTTTAGACAAAGCTTAAATGACCATGAAGAAAATTGTTTGGAGATAATTATAAAATT
CAGTGACCTTTGAGAACCTGAACATTATAGAAAAGCTGGCAATAATCAAGGACTTACTGAAGTAGTCTGTTGGTTCAGTGCATGCTTAGT
TGGCAGTTACCACCCTGTGCTAGCATATTTCTTTTGCTAGCTATCCATCATGTAACCCTCATGAAAATTATCTTTATACGTGGACTATAA
TAAAATATTGAATTAAAACCTTAGAAAAGAAACCTTGTTTATTCCCTGTGAAAATGAGAAGATTTCTAAACAGCTCCACCTTTGTTACAA
TATTGTGAAAGATCGTTATGTTCGAGTTTCAAATAACAATCAAACCATTTCTGGATGGGAGAATGGCGTGTGGAAAATGGAATCTATATT
CAGAAAAGTTGAAACAGACTGGCACATGAGGCAACTGTTTTTGTCAGAAAACAGAAGGAAAGAACTTCTCCAGAGGATAATTGTGGAGCT
TGTTGAATTTATATCTCCCAAAACCCCTAAACCTGGAGAACTTGGGGGAAGAATATCTGGGTCAGTGGCTTGGAGAGTAGCCCGAGGTGA
AATGGGTCTACAGGTAGTTGATGTCACTTGGCGATATTCCTGCAAACATGAAGAGGTGATTGCCAGAAGAACTAAGGTTAAAGAAGCATT
ACTTCGAGACACTATTAATGGGCTTAATAAGCAGACCATGTCTGGACAGAAGTCTATTCTCCTTCTCAGCAGCGGTGGCTGCACTGTGAT
GCATGTGAAGATGTCTGTGACAAGCCACTCCTTTATGAAATAGGATGGGGCAAGAAGCTTTCCTATGTCATAGCATTTTCAAAAGATGAG
ATATAATAACCCTGAGAAACTTTTGGAAACAAGATGTGGACGGTGTGGCGAGTGGGCCAATTGTTTTACACTGTGCTGCCGAGCTGTAGG
GTTTGAAGCTCGCTATGTTTGGGATTACACAGGTATCAATATAAGTGATGAGGATTTTCTTTTGCTGGAGCTTTTGCACTGGTTTAAGGA
AGAATTTTTTCACTGGGTGAATAACGTTTTGTGCAGCAAATGTGGTGGACAGACTAGGTCTAGAGATAGATCATTACTGCCCAGTGATGA
TGAGCTGAAGTGGGGTGCAAAGGAAGTGGAAGATCATTACTGTGATGCCTGCCAGTTCAGCAATCGATTCCCAAGGTTGCTGCTGACTCA
GCCATTCTAGAAGTTCTTCAGTCCAACATTCAGCATGTGCTGGTCTATGAAAATCCTGCTCTTCAGGAGAAAGCGTTGGCTTGTATTCCG
GTCCAAGAACTAAAAAGGAAATCACAAGAAAAGTTATCGAGAGCTAGAAAATTGGATAAAGGGAGAAACACATCTCATCTTTCCTAAAAA
AGCTTCAGTGGAGCAGCTGCAAAAAATTCGTGACCTGATTGCCATAGAGAGAAGTAGCAGACTGGATGGCTCAAATAAGAGCCACAAAGT
AAAGTCATCTCAGCAACCTGCAGCCAGTACCCAGCTTCCTACAACACCATCTTCAAATCCCAGTGGGTTAAACCAGCACACAAGGAACCG
TCAAGGGCAGTCATCAGATCCACCATCTGCTTCAACGGATCCATCCGGATTGGAAACACAGCCTTTTCTACTAGACTCTTGCCTGTCAGA

>75233_75233_2_RNU6-2-NGLY1_RNU6-2_chr19_1021628_ENST00000384627_NGLY1_chr3_25820156_ENST00000396649_length(amino acids)=182AA_BP=
MFIPCENEKISKQLHLCYNIVKDRYVRVSNNNQTISGWENGVWKMESIFRKVETDWHMRQLFLSENRRKELLQRIIVELVEFISPKTPKP
GELGGRISGSVAWRVARGEMGLQVVDVTWRYSCKHEEVIARRTKVKEALLRDTINGLNKQTMSGQKSILLLSSGGCTVMHVKMSVTSHSF

--------------------------------------------------------------
>75233_75233_3_RNU6-2-NGLY1_RNU6-2_chr19_1021628_ENST00000384627_NGLY1_chr3_25820156_ENST00000417874_length(transcript)=1967nt_BP=107nt
GTGCTCGCTTCGGCAGCACATATACTAAAATTGGAACGATACAGAGAAGATTAGCATGGCCCCTGCGCAAGGATGACACGCAAATTCGTG
AAGCGTTCCATATTTTTATAACAGTCTTCACTCCTATGCTGATTTTTCTGGTGCCACTGAAGTTATTTTGGAAGCAGAATTAAGCAGAGG
AGATGGTGATGTCGCTTGGCAACACACCCAGCTGTTTAGACAAAGCTTAAATGACCATGAAGAAAATTGTTTGGAGATAATTATAAAATT
CAGTGACCTTTGAGAACCTGAACATTATAGAAAAGCTGGCAATAATCAAGGACTTACTGAAGGTATATTTGGCCCGAAAGGAAGGATCAT
CTTTTGCTTATATTTCCTGGAAGTTTGAGTGTGGGTCAGTTGGCCTAAAAGTAGATAGCATTTCTATTAGAACAAGTAGTCAAACTTTTC
AGACTGGAACAGTAGAATGGAAATTGCGATCTGATACAGCACAAGTAGAACTGACAGGCGAGAAAAGAAACCTTGTTTATTCCCTGTGAA
AATGAGAAGATTTCTAAACAGCTCCACCTTTGTTACAATATTGTGAAAGATCGTTATGTTCGAGTTTCAAATAACAATCAAACCATTTCT
GGATGGGAGAATGGCGTGTGGAAAATGGAATCTATATTCAGAAAAGTTGAAACAGACTGGCACATGAGGCAACTGTTTTTGTCAGAAAAC
AGAAGGAAAGAACTTCTCCAGAGGATAATTGTGGAGCTTGTTGAATTTATATCTCCCAAAACCCCTAAACCTGGAGAACTTGGGGGAAGA
ATATCTGGGTCAGTGGCTTGGAGAGTAGCCCGAGGTGAAATGGGTCTACAGGTAGTTGATGTCACTTGGCGATATTCCTGCAAACATGAA
GAGGTGATTGCCAGAAGAACTAAGGTTAAAGAAGCATTACTTCGAGACACTATTAATGGGCTTAATAAGCAGACCATGTCTGGACAGAAG
TCTATTCTCCTTCTCAGCAGCGGTGGCTGCACTGTGATGCATGTGAAGATGTCTGTGACAAGCCACTCCTTTATGAAATAGGATGGGGCA
AGAAGCTTTCCTATGTCATAGCATTTTCAAAAGATGAGATATAATAACCCTGAGAAACTTTTGGAAACAAGATGTGGACGGTGTGGCGAG
TGGGCCAATTGTTTTACACTGTGCTGCCGAGCTGTAGGGTTTGAAGCTCGCTATGTTTGGGATTACACAGGTATCAATATAAGTGATGAG
GATTTTCTTTTGCTGGAGCTTTTGCACTGGTTTAAGGAAGAATTTTTTCACTGGGTGAATAACGTTTTGTGCAGCAAATGTGGTGGACAG
ACTAGGTCTAGAGATAGATCATTACTGCCCAGTGATGATGAGCTGAAGTGGGGTGCAAAGGAAGTGGAAGATCATTACTGTGATGCCTGC
CAGTTCAGCAATCGATTCCCAAGGTTGCTGCTGACTCAGCCATTCTAGAAGTTCTTCAGTCCAACATTCAGCATGTGCTGGTCTATGAAA
ATCCTGCTCTTCAGGAGAAAGCGTTGGCTTGTATTCCGGTCCAAGAACTAAAAAGGAAATCACAAGAAAAGTTATCGAGAGCTAGAAAAT
TGGATAAAGGGAGAAACACATCTCATCTTTCCTAAAAAAGCTTCAGTGGAGCAGCTGCAAAAAATTCGTGACCTGATTGCCATAGAGAGA
AGTAGCAGACTGGATGGCTCAAATAAGAGCCACAAAGTAAAGTCATCTCAGCAACCTGCAGCCAGTACCCAGCTTCCTACAACACCATCT
TCAAATCCCAGTGGGTTAAACCAGCACACAAGGAACCGTCAAGGGCAGTCATCAGATCCACCATCTGCTTCAACGGATCCATCCGGATTG

>75233_75233_3_RNU6-2-NGLY1_RNU6-2_chr19_1021628_ENST00000384627_NGLY1_chr3_25820156_ENST00000417874_length(amino acids)=182AA_BP=
MFIPCENEKISKQLHLCYNIVKDRYVRVSNNNQTISGWENGVWKMESIFRKVETDWHMRQLFLSENRRKELLQRIIVELVEFISPKTPKP
GELGGRISGSVAWRVARGEMGLQVVDVTWRYSCKHEEVIARRTKVKEALLRDTINGLNKQTMSGQKSILLLSSGGCTVMHVKMSVTSHSF

--------------------------------------------------------------
>75233_75233_4_RNU6-2-NGLY1_RNU6-2_chr19_1021628_ENST00000384627_NGLY1_chr3_25820156_ENST00000428257_length(transcript)=2379nt_BP=107nt
GTGCTCGCTTCGGCAGCACATATACTAAAATTGGAACGATACAGAGAAGATTAGCATGGCCCCTGCGCAAGGATGACACGCAAATTCGTG
AAGCGTTCCATATTTTTATAACAGTCTTCACTCCTATGCTGATTTTTCTGGTGCCACTGAAGTTATTTTGGAAGCAGAATTAAGCAGAGG
AGATGGTGATGTCGCTTGGCAACACACCCAGCTGTTTAGACAAAGCTTAAATGACCATGAAGAAAATTGTTTGGAGATAATTATAAAATT
CAGTGACCTTTGAGAACCTGAACATTATAGAAAAGCTGGCAATAATCAAGGACTTACTGAAGTAGTCTGTTGGTTCAGTGCATGCTTAGT
TGGCAGTTACCACCCTGTGCTAGCATATTTCTTTTGCTAGCTATCCATCATGTAACCCTCATGAAAATTATCTTTATACGTGGACTATAA
TAAAATATTGAATTAAAACCTTTCTTCCATATGTGACTATAATTTGGAGTAAAGTCTTGTTGACTCAATATGGGATTTTAATCTAAAACT
GTAAGTATGGTTTTAAAAGTTAAATAATGATATTCATGATTAAATGCTATTCATGATTATGATAAAATCTTGGGCTTATGATAGTAATTT
GACATTTTCTGATCAGCCATTCATTTCTTCAGAAGTGGTTAAATTAGAGTCTCCTAATATTTTTAATTAATGTGAAAGTACAGTAGCTCA
TAAATTATATAATGCATGAAAATTTATATGATTATAAATATTCAGGCATTTAAGAAATAAAATGAAGTATTTTGCCTTGTATATTTGGCC
CGAAAGGAAGGATCATCTTTTGCTTATATTTCCTGGAAGTTTGAGTGTGGGTCAGTTGGCCTAAAAGTAGATAGCATTTCTATTAGAACA
AGTAGTCAAACTTTTCAGACTGGAACAGTAGAATGGAAATTGCGATCTGATACAGCACAAGTAGAACTGACAGGCGAGAAAAGAAACCTT
GTTTATTCCCTGTGAAAATGAGAAGATTTCTAAACAGCTCCACCTTTGTTACAATATTGTGAAAGATCGTTATGTTCGAGTTTCAAATAA
CAATCAAACCATTTCTGGATGGGAGAATGGCGTGTGGAAAATGGAATCTATATTCAGAAAAGTTGAAACAGACTGGCACATGAGGCAACT
GTTTTTGTCAGAAAACAGAAGGAAAGAACTTCTCCAGAGGATAATTGTGGAGCTTGTTGAATTTATATCTCCCAAAACCCCTAAACCTGG
AGAACTTGGGGGAAGAATATCTGGGTCAGTGGCTTGGAGAGTAGCCCGAGGTGAAATGGGTCTACAGGTAGTTGATGTCACTTGGCGATA
TTCCTGCAAACATGAAGAGGTGATTGCCAGAAGAACTAAGGTTAAAGAAGCATTACTTCGAGACACTATTAATGGGCTTAATAAGCAGAG
TTACAGCGCACATTAAGCCTAAAACTGACCACGTTAAAGGAGATTGGAAAAACATTTTTAAGGATTTCAAAGAGACAGAAATTAATACAG
ATATAATAACCCTGAGAAACTTTTGGAAACAAGATGTGGACGGTGTGGCGAGTGGGCCAATTGTTTTACACTGTGCTGCCGAGCTGTAGG
GTTTGAAGCTCGCTATGTTTGGGATTACACAGGTATCAATATAAGTGATGAGGATTTTCTTTTGCTGGAGCTTTTGCACTGGTTTAAGGA
AGAATTTTTTCACTGGGTGAATAACGTTTTGTGCAGCAAATGTGGTGGACAGACTAGGTCTAGAGATAGATCATTACTGCCCAGTGATGA
TGAGCTGAAGTGGGGTGCAAAGGAAGTGGAAGATCATTACTGTGATGCCTGCCAGTTCAGCAATCGATTCCCAAGGTTGCTGCTGACTCA
GCCATTCTAGAAGTTCTTCAGTCCAACATTCAGCATGTGCTGGTCTATGAAAATCCTGCTCTTCAGGAGAAAGCGTTGGCTTGTATTCCG
GTCCAAGAACTAAAAAGGAAATCACAAGAAAAGTTATCGAGAGCTAGAAAATTGGATAAAGGGAGAAACACATCTCATCTTTCCTAAAAA
AGCTTCAGTGGAGCAGCTGCAAAAAATTCGTGACCTGATTGCCATAGAGAGAAGTAGCAGACTGGATGGCTCAAATAAGAGCCACAAAGT
AAAGTCATCTCAGCAACCTGCAGCCAGTACCCAGCTTCCTACAACACCATCTTCAAATCCCAGTGGGTTAAACCAGCACACAAGGAACCG
TCAAGGGCAGTCATCAGATCCACCATCTGCTTCAACGGATCCATCCGGATTGGAAACACAGCCTTTTCTACTAGACTCTTGCCTGTCAGA

>75233_75233_4_RNU6-2-NGLY1_RNU6-2_chr19_1021628_ENST00000384627_NGLY1_chr3_25820156_ENST00000428257_length(amino acids)=155AA_BP=
MFIPCENEKISKQLHLCYNIVKDRYVRVSNNNQTISGWENGVWKMESIFRKVETDWHMRQLFLSENRRKELLQRIIVELVEFISPKTPKP

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Fusion Gene PPI Analysis for RNU6-2-NGLY1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for RNU6-2-NGLY1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for RNU6-2-NGLY1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneC3808991NGLY1 deficiency7CLINGEN;CTD_human;GENOMICS_ENGLAND;ORPHANET