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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:DLC1-SKI (FusionGDB2 ID:HG10395TG6497)

Fusion Gene Summary for DLC1-SKI

check button Fusion gene summary
Fusion gene informationFusion gene name: DLC1-SKI
Fusion gene ID: hg10395tg6497
HgeneTgene
Gene symbol

DLC1

SKI

Gene ID

10395

6497

Gene nameDLC1 Rho GTPase activating proteinSKI proto-oncogene
SynonymsARHGAP7|HP|STARD12|p122-RhoGAPSGS|SKV
Cytomap('DLC1')('SKI')

8p22

1p36.33-p36.32

Type of geneprotein-codingprotein-coding
Descriptionrho GTPase-activating protein 7Rho-GTPase-activating protein 7START domain-containing protein 12StAR-related lipid transfer (START) domain containing 12deleted in liver cancer 1 proteindeleted in liver cancer 1 variant 2deleted in liver cancer variaski oncogeneproto-oncogene c-Skiski oncoproteinv-ski avian sarcoma viral oncogene homolog
Modification date2020031320200329
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000358919, ENST00000276297, 
ENST00000316609, ENST00000510318, 
ENST00000511869, ENST00000512044, 
ENST00000520226, 
Fusion gene scores* DoF score5 X 4 X 4=8017 X 5 X 6=510
# samples 517
** MAII scorelog2(5/80*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(17/510*10)=-1.58496250072116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: DLC1 [Title/Abstract] AND SKI [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointDLC1(12990452)-SKI(2234416), # samples:1
Anticipated loss of major functional domain due to fusion event.DLC1-SKI seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
DLC1-SKI seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneDLC1

GO:0006915

apoptotic process

17292327

HgeneDLC1

GO:0006919

activation of cysteine-type endopeptidase activity involved in apoptotic process

17888903

HgeneDLC1

GO:0008285

negative regulation of cell proliferation

12545165|17932950

HgeneDLC1

GO:0030336

negative regulation of cell migration

17932950|19158340

HgeneDLC1

GO:0035307

positive regulation of protein dephosphorylation

17292327

HgeneDLC1

GO:0051497

negative regulation of stress fiber assembly

17932950

HgeneDLC1

GO:0051895

negative regulation of focal adhesion assembly

19158340

HgeneDLC1

GO:1900119

positive regulation of execution phase of apoptosis

17888903

TgeneSKI

GO:0000122

negative regulation of transcription by RNA polymerase II

17469184

TgeneSKI

GO:0008285

negative regulation of cell proliferation

11430826

TgeneSKI

GO:0014902

myotube differentiation

19008232

TgeneSKI

GO:0030512

negative regulation of transforming growth factor beta receptor signaling pathway

17469184

TgeneSKI

GO:0030514

negative regulation of BMP signaling pathway

14699069

TgeneSKI

GO:0032926

negative regulation of activin receptor signaling pathway

14699069

TgeneSKI

GO:0043388

positive regulation of DNA binding

15107821

TgeneSKI

GO:0045668

negative regulation of osteoblast differentiation

14699069

TgeneSKI

GO:0060395

SMAD protein signal transduction

12874272


check buttonFusion gene breakpoints across DLC1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across SKI (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4ESCATCGA-IG-A3YADLC1chr8

12990452

-SKIchr1

2234416

+


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Fusion Gene ORF analysis for DLC1-SKI

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000358919ENST00000478223DLC1chr8

12990452

-SKIchr1

2234416

+
In-frameENST00000358919ENST00000378536DLC1chr8

12990452

-SKIchr1

2234416

+
intron-3CDSENST00000276297ENST00000378536DLC1chr8

12990452

-SKIchr1

2234416

+
intron-3CDSENST00000316609ENST00000378536DLC1chr8

12990452

-SKIchr1

2234416

+
intron-3CDSENST00000510318ENST00000378536DLC1chr8

12990452

-SKIchr1

2234416

+
intron-3CDSENST00000511869ENST00000378536DLC1chr8

12990452

-SKIchr1

2234416

+
intron-3CDSENST00000512044ENST00000378536DLC1chr8

12990452

-SKIchr1

2234416

+
intron-3CDSENST00000520226ENST00000378536DLC1chr8

12990452

-SKIchr1

2234416

+
intron-3UTRENST00000276297ENST00000478223DLC1chr8

12990452

-SKIchr1

2234416

+
intron-3UTRENST00000316609ENST00000478223DLC1chr8

12990452

-SKIchr1

2234416

+
intron-3UTRENST00000510318ENST00000478223DLC1chr8

12990452

-SKIchr1

2234416

+
intron-3UTRENST00000511869ENST00000478223DLC1chr8

12990452

-SKIchr1

2234416

+
intron-3UTRENST00000512044ENST00000478223DLC1chr8

12990452

-SKIchr1

2234416

+
intron-3UTRENST00000520226ENST00000478223DLC1chr8

12990452

-SKIchr1

2234416

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000358919DLC1chr812990452-ENST00000378536SKIchr12234416+51035311939782385

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000358919ENST00000378536DLC1chr812990452-SKIchr12234416+0.853213670.14678636

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Fusion Genomic Features for DLC1-SKI


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
DLC1chr812990452-SKIchr12234416+0.012169540.98783046
DLC1chr812990452-SKIchr12234416+0.012169540.98783046

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for DLC1-SKI


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr8:12990452/chr1:2234416)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneSKIchr8:12990452chr1:2234416ENST0000037853607536_710323729.0Coiled coilOntology_term=ECO:0000255

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneDLC1chr8:12990452chr1:2234416ENST00000276297-118741_74701529.0Compositional biasNote=Poly-Ser
HgeneDLC1chr8:12990452chr1:2234416ENST00000276297-118868_87401529.0Compositional biasNote=Poly-Ser
HgeneDLC1chr8:12990452chr1:2234416ENST00000316609-16741_7470499.0Compositional biasNote=Poly-Ser
HgeneDLC1chr8:12990452chr1:2234416ENST00000316609-16868_8740499.0Compositional biasNote=Poly-Ser
HgeneDLC1chr8:12990452chr1:2234416ENST00000358919-114741_747121092.0Compositional biasNote=Poly-Ser
HgeneDLC1chr8:12990452chr1:2234416ENST00000358919-114868_874121092.0Compositional biasNote=Poly-Ser
HgeneDLC1chr8:12990452chr1:2234416ENST00000511869-15741_7470464.0Compositional biasNote=Poly-Ser
HgeneDLC1chr8:12990452chr1:2234416ENST00000511869-15868_8740464.0Compositional biasNote=Poly-Ser
HgeneDLC1chr8:12990452chr1:2234416ENST00000520226-114741_74701018.0Compositional biasNote=Poly-Ser
HgeneDLC1chr8:12990452chr1:2234416ENST00000520226-114868_87401018.0Compositional biasNote=Poly-Ser
HgeneDLC1chr8:12990452chr1:2234416ENST00000276297-1181078_128401529.0DomainRho-GAP
HgeneDLC1chr8:12990452chr1:2234416ENST00000276297-1181314_152101529.0DomainSTART
HgeneDLC1chr8:12990452chr1:2234416ENST00000276297-118448_51501529.0DomainNote=SAM
HgeneDLC1chr8:12990452chr1:2234416ENST00000316609-161078_12840499.0DomainRho-GAP
HgeneDLC1chr8:12990452chr1:2234416ENST00000316609-161314_15210499.0DomainSTART
HgeneDLC1chr8:12990452chr1:2234416ENST00000316609-16448_5150499.0DomainNote=SAM
HgeneDLC1chr8:12990452chr1:2234416ENST00000358919-1141078_1284121092.0DomainRho-GAP
HgeneDLC1chr8:12990452chr1:2234416ENST00000358919-1141314_1521121092.0DomainSTART
HgeneDLC1chr8:12990452chr1:2234416ENST00000358919-114448_515121092.0DomainNote=SAM
HgeneDLC1chr8:12990452chr1:2234416ENST00000511869-151078_12840464.0DomainRho-GAP
HgeneDLC1chr8:12990452chr1:2234416ENST00000511869-151314_15210464.0DomainSTART
HgeneDLC1chr8:12990452chr1:2234416ENST00000511869-15448_5150464.0DomainNote=SAM
HgeneDLC1chr8:12990452chr1:2234416ENST00000520226-1141078_128401018.0DomainRho-GAP
HgeneDLC1chr8:12990452chr1:2234416ENST00000520226-1141314_152101018.0DomainSTART
HgeneDLC1chr8:12990452chr1:2234416ENST00000520226-114448_51501018.0DomainNote=SAM
HgeneDLC1chr8:12990452chr1:2234416ENST00000276297-1181051_107301529.0RegionNote=Polybasic cluster (PBR)
HgeneDLC1chr8:12990452chr1:2234416ENST00000276297-118710_88401529.0RegionNote=Focal adhesion-targeting (FAT)
HgeneDLC1chr8:12990452chr1:2234416ENST00000316609-161051_10730499.0RegionNote=Polybasic cluster (PBR)
HgeneDLC1chr8:12990452chr1:2234416ENST00000316609-16710_8840499.0RegionNote=Focal adhesion-targeting (FAT)
HgeneDLC1chr8:12990452chr1:2234416ENST00000358919-1141051_1073121092.0RegionNote=Polybasic cluster (PBR)
HgeneDLC1chr8:12990452chr1:2234416ENST00000358919-114710_884121092.0RegionNote=Focal adhesion-targeting (FAT)
HgeneDLC1chr8:12990452chr1:2234416ENST00000511869-151051_10730464.0RegionNote=Polybasic cluster (PBR)
HgeneDLC1chr8:12990452chr1:2234416ENST00000511869-15710_8840464.0RegionNote=Focal adhesion-targeting (FAT)
HgeneDLC1chr8:12990452chr1:2234416ENST00000520226-1141051_107301018.0RegionNote=Polybasic cluster (PBR)
HgeneDLC1chr8:12990452chr1:2234416ENST00000520226-114710_88401018.0RegionNote=Focal adhesion-targeting (FAT)


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Fusion Gene Sequence for DLC1-SKI


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>22980_22980_1_DLC1-SKI_DLC1_chr8_12990452_ENST00000358919_SKI_chr1_2234416_ENST00000378536_length(transcript)=5103nt_BP=531nt
GAGGCTGCGGCCACGAGGAAGAGGGGCGGGGGGCGGAGCCTGGGAATGGGGCGGGGCCGGAGAACAGCCCGTCGCTAAGGCCTGCGACCC
AGACAGCGGGGAGGAGGCGGTGCCGCCCGCTCTGGCCCCGCCCCTCGGGGGGTGGGCCCAGCGGGAGGGCCCGGCTGGCGGAGCGCGCGG
GAGACAGTTCGCTCCGACTGCCCGAGCGAGGGCGCTTCGCTCCCAGCCAGGACATGGCCGCACCTCTCCGCATCAGGAGCGCCGGCTCAC
GGACTTCTCGCCCAACTCCCTGAGCGCTCCCTCGTTTCGATCTTTAGAAAACCCCGCTTTCTTTCTGGGGCCGTGACGAGGGGCAGGGAG
CGGCGAGCAAGGATGCGTTGAGGACCGCGAGGGCGCGCGTCTCGGGTGCCGCCGTGGGTCCCGACGCGGAAGCCGAGCCGCCTCCGCCTG
CCTCGACTTCCCCACAGCGCTTCCGCCGCCGCCTGCCGTGCTTGATGTGCAGAAAGAAGCCGGACACCATGATCCTAACACGTCTCCTCT
GAGCCTCCGGCCTCCATAAGACCCAAAACAGATGACACCTCTTCCCAGTCCCCCGCGCCTTCCGAAAAGGACAAGCCGTCCAGCTGGCTG
CGGACCTTGGCCGGCTCTTCCAATAAGAGCCTGGGCTGTGTTCACCCTCGCCAGCGCCTCTCTGCTTTCCGACCCTGGTCCCCCGCAGTG
TCAGCGAGTGAGAAAGAGCTCTCCCCACACCTCCCGGCCCTCATCCGAGACAGCTTCTACTCCTACAAGAGCTTTGAGACAGCCGTGGCG
CCCAACGTGGCCCTCGCACCGCCGGCCCAGCAGAAGGTTGTGAGCAGCCCTCCGTGTGCCGCCGCCGTCTCCCGGGCCCCCGAGCCTCTC
GCCACTTGCACCCAGCCTCGGAAGCGGAAGCTGACTGTGGACACCCCAGGAGCCCCAGAGACGCTGGCGCCCGTGGCTGCCCCAGAGGAG
GACAAGGACTCGGAGGCGGAGGTGGAAGTTGAAAGCAGGGAGGAATTCACCTCCTCCTTGTCCTCGCTCTCTTCCCCGTCCTTTACCTCA
TCCAGCTCCGCCAAGGACCTGGGCTCCCCGGGTGCGCGTGCCCTGCCCTCGGCCGTCCCTGATGCTGCGGCCCCTGCCGACGCCCCCAGT
GGGCTGGAGGCGGAGCTGGAGCACCTGCGGCAGGCACTGGAGGGCGGCCTGGACACCAAGGAAGCCAAAGAGAAGTTCCTGCATGAGGTG
GTCAAGATGCGCGTGAAGCAGGAGGAGAAGCTCAGCGCAGCCCTGCAGGCCAAGCGCAGCCTCCACCAGGAGCTGGAGTTCCTACGCGTG
GCCAAGAAGGAGAAGCTGCGGGAGGCCACGGAGGCCAAGCGTAACCTGCGGAAGGAGATCGAGCGTCTCCGCGCCGAGAACGAGAAGAAG
ATGAAAGAGGCCAACGAGTCACGGCTGCGCCTGAAGCGGGAGCTGGAGCAGGCGCGGCAGGCCCGGGTGTGCGACAAGGGCTGCGAGGCG
GGCCGCCTGCGCGCCAAGTACTCGGCCCAGATCGAAGACCTGCAGGTGAAGCTGCAGCACGCGGAGGCGGACCGGGAGCAGCTGCGGGCC
GACCTGCTGCGGGAGCGCGAGGCCCGGGAGCACCTGGAGAAGGTGGTGAAGGAGCTGCAGGAACAGCTGTGGCCGCGGGCCCGCCCCGAG
GCTGCGGGCAGCGAGGGCGCTGCGGAGCTGGAGCCGTAGATTCCGTGCCTGCCGCCGCAGCGCCGCCGACAACGCGGGTGCAGGGGGGCG
CGGCTGGGCGGTGCAGCTCCGCCCGGCTCCGCCCCTGCAGCCCACACAGCACAACGTCTTACCGTGCCTATTACCAAGCGAGTGTTTGTA
ACCATGTAGTTTTGGAACCCACTGCAAAATTTTCTACTGGCCAAGTTCAAGTGAGTAAGCCGCGTCCCCCAACTACAGCTGGAGACGGGG
CCAGCTCGGCGGCCTGCTGGTCCTCTGCTTGCTGGAACATTCTAACATTTACACTTTTGTTATAAGCTATTTAAAACCAGTAAGGAGACT
TGAAATTCAGAAAATCAACACATTTTTAAATGACTAACTTCTAAAAGCCCCAACACATGACGCCATCTGAAGACCCGCAACGGAGTGGGG
GTGGCGGCCGCCCCACCCTCCCCACCCGGGGAAGCCATCACAGCTCATCTGCCCGCGGCTGCGTGAGGACAGCAGGGGTTTTTCTTCAGA
GTCTATTTTTTCAGCGACAAGGACCCAGGTCTTCCTGCTGCTGCCAGGGAGAGCAGGGACAGTGCCGCGTGCGAGATGAGCTCGAACACT
GCCCGCCTTACTGCCGCCTACCCCGCCCGCCACGCCGCCGTCGATGCCAGCGCTGTCCCCACGGGTACCAGGAAGTGCAGAGCCGCACAG
GAGCTGCCCCGGAGCTGAGGGGACGGTCTTCGGCTCCTCTGCACCCCGTGATTCTGCCCACGCTCCTCCACCACGAGGCACTGACCTGCG
TCGGGTGGTGACCGTGGCTGGCGGTCACGCCCTCAGCCCCTCCGGGCACACGTGCCGCCTGACCGGGCGACCCTTTTCAGTTCGGCAAAC
GTCGCTCCCTTCATTTTGGGACTGAGGCTGCAGCATTGGAACAAAAGAGCATTATTTCAATTTTTCTTTCTTTTTTTTTGTTCGTTCATT
TAAACGTATATTTAGAACTGCACTTTGTCCACAACCTTCCCTTCTCTTTCTATTCCCCAGTGAACTGAGGTTTTTACCGATTTATAGAGC
AGTCAAATCCGAAGTGCTCGAGTGCTTAGAAACCCCCTCTGGTGCTTGGTTGAACAAGGGAATCACAAGAAAACGAAAATGCAAAAACTG
AACTTCGGGGGTCGTTCTGTGCCTTCCAGCATCTTGTACAGCAAATCCTGACTCGTGTCTTTTTACCCCCAAGATATCTGTCTTCAGTAG
CGACTGAATCTGCCACTCTCAGAATAAGTTCCTTGCATTTATTCCAAATAATCTCGTTTACTCTCACCTGTTTATGCAAATTGTATAAGG
TTTCTTATGCCCAAGCTTGAAAAATGATTTCCCAGTAGACAAGAGGCGGCTACCTATCCTACAGTTACGGTATTTATTTACATAAGAAGA
TCTTACAGGAGTTCTTTGCTTGAATCCGTTCTAACACCCGCGGCAGCTGCACGCGCTCACAGAAGGTGGAGGTTACTTGCCCAGGTACAG
ACGACCTCGGGGCAGTGACGAGCAAAGACCAGAGACTGCTGAGCCCTCGCATCTGGGTGGCGGAATTGCCTGCGGGGTTTTGCCCTTGGT
TTACTGAGGGGGGTCTTGGTTGCTGCTGAAGCCCCCCACCCCTTCTAAAGTGCAATGCAAAAGGGACATCATGTATATGCAGCGTTTGTT
TGGAATTTTCTTTGCTTTTGTTTTCTTTGCGGTTGTTCTGTGTGCATGGATTCCACACCTCTGCCGTAGGTAGATCCGTCAGCGGGCATT
ATTACCGTGTCTTGTAAAGGGTCGGTTTTGTTATGCAACATGCAGAATGCTGTTTTTAGCCTTGTTTTACCAGAGTTGTTTTTTTTTTCA
GTTATTTCTTCAAGGGAAACTAAATGATTTAGTTGGAGCAAAGCTTTAAGTGTGTTGGCGTGCTTCTGTGTGGCTGTCCTGTGTCGCCAG
GTCGAAGATCACAGTGAGGTAGAGGCCCTGCCCCATCCCCAGGGCCGCCAGGCTTGCTCCGTTTGCTTTGAGTTTTTAGACCCCAGAGGG
AGATGAGCTTTTCCAAGCTGTGTCTGGGCCAGAGCCTCTCCTTGCCCTTGCTCCATCCCGACGGTCACCGTTGGGTCCACGCCTCCACCG
CCCCATCTTGCCCCAAACGGAAAGCGCTGTATCTGCAGTGGCAGCCCTTCCCCACTTCGGCTCTGGGAGGGTCCAGCCAGTGTCACCTGG
GCCCACCCTTTCCTGCAGCTGCCAGGCCCGTGCGGTCAGTGGGACCCGGACGTGGGCAGGCGAGCTCGGGACCCTCCCAGGCAGTTCCCA
CAGCTCTTGCCTCGGCTCACCAGGGTCACTTCCACTGTCAGGGGCCTGAGGGGGCAGCTGTGGCTGCAGGGCTGCTCTGGACTGAGGGGT
CCCAGGCCCCGAGGGGTGCACGCCTGGCTCCCCTTGGCACAGGTGCGAGTCCGTTTCTTTTCAGCAGAAGGGGGAAGAGGTGTCCGCTGT
GTGGGCTGCTGACTCCTCTGTGTGTGAGGCCCTTCATCTAAGTGATTGTGTATTCAGTTTAATTCTCATTATATTTCTATACTGAAAGAA
GATTTTTAACGAAGGGAAAAACAACAGCAATAACATTCATATCTCTGGAGCAGCTAACTCATACACGTAATGTCTGCTTTTCGTACAGAA
CTAGCCAATGTAAAAACAGTTCACCTGTAAATACTTTTTCCTTTTTCACCGTTGTATTATACATGTATATGCTGGGTCCTTTTTCAGAAA
CTCTTTTCTTACCTGAGAGTTGTCTTGTTTTCTGGGCTGTTTTTAACTGAGGAAAAAAAAAATGCTTTCCTGCCGGGGGGCAGGGGAGAC
GGAGAAACCCATGTGCGTTTCCCATGTGACCCCCTCCTCCCTGTGGGTCTGAGCCCCGGCCCCCCCCACCTCCTCCTCCCTGTGGGTCCG
AACCCCGGCCCCCCCACCCCCTCCTCCCTGTGGGTCCGAACCCCGGCCCCCCCACCCCCTCCTCCCTGTGGGTCCGATCCCCGGCCCCCC
CCACCCCCTCCTCCCTGTGGGTCCGAACCCCGGCCCCCCCCCCACCCCCTCCTCCCTGTGGGTCCGAACCCCGGCCCCCCCACCCCTCCC
TCAGCCCACCAGGGTCCAGGGAGATGTTCGTTCTCGCTTTAAGTCAGGAGTCACAAATGACTTTTTTTTTTCAATTAAGGAAAAAGCTCC
ATCTCTACCTTTAACATCACCCAGACCCCCGCCCCTGCCCGTGCCCCACGCTGCTGCTAACGACAGTATGATGCTTACTCTGCTACTCGG

>22980_22980_1_DLC1-SKI_DLC1_chr8_12990452_ENST00000358919_SKI_chr1_2234416_ENST00000378536_length(amino acids)=385AA_BP=
MNLASRKFCSGFQNYMVTNTRLVIGTVRRCAVWAAGAEPGGAAPPSRAPLHPRCRRRCGGRHGIYGSSSAAPSLPAASGRARGHSCSCSS
FTTFSRCSRASRSRSRSARSCSRSASACCSFTCRSSIWAEYLARRRPASQPLSHTRACRACSSSRFRRSRDSLASFIFFSFSARRRSISF
RRLRLASVASRSFSFLATRRNSSSWWRLRLACRAALSFSSCFTRILTTSCRNFSLASLVSRPPSSACRRCSSSASSPLGASAGAAASGTA
EGRARAPGEPRSLAELDEVKDGEESEDKEEVNSSLLSTSTSASESLSSSGAATGASVSGAPGVSTVSFRFRGWVQVARGSGARETAAAHG

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Fusion Gene PPI Analysis for DLC1-SKI


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for DLC1-SKI


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for DLC1-SKI


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneDLC1C0006826Malignant Neoplasms1CTD_human
HgeneDLC1C0024623Malignant neoplasm of stomach1CTD_human
HgeneDLC1C0027651Neoplasms1CTD_human
HgeneDLC1C0038356Stomach Neoplasms1CTD_human
HgeneDLC1C0086692Benign Neoplasm1CTD_human
HgeneDLC1C0919267ovarian neoplasm1CTD_human
HgeneDLC1C1140680Malignant neoplasm of ovary1CTD_human
HgeneDLC1C1708349Hereditary Diffuse Gastric Cancer1CTD_human
TgeneC1321551Shprintzen-Goldberg syndrome4CLINGEN;CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
TgeneC1842870Chromosome 1p36 Deletion Syndrome2ORPHANET
TgeneC0003486Aortic Aneurysm1CTD_human
TgeneC0011999Diastematomyelia1CTD_human
TgeneC0027794Neural Tube Defects1CTD_human
TgeneC0027806Neurenteric Cyst1CTD_human
TgeneC0080218Tethered Cord Syndrome1CTD_human
TgeneC0151491Congenital musculoskeletal anomalies1CTD_human
TgeneC0152234Iniencephaly1CTD_human
TgeneC0152426Craniorachischisis1CTD_human
TgeneC0266453Exencephaly1CTD_human
TgeneC0344479Spinal Cord Myelodysplasia1CTD_human
TgeneC0376634Craniofacial Abnormalities1CTD_human
TgeneC0702169Acrania1CTD_human