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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:SNHG14-FUNDC1 (FusionGDB2 ID:HG104472715TG139341)

Fusion Gene Summary for SNHG14-FUNDC1

check button Fusion gene summary
Fusion gene informationFusion gene name: SNHG14-FUNDC1
Fusion gene ID: hg104472715tg139341
HgeneTgene
Gene symbol

SNHG14

FUNDC1

Gene ID

104472715

139341

Gene namesmall nucleolar RNA host gene 14FUN14 domain containing 1
Synonyms115HG|IC-SNURF-SNRPN|LNCAT|NCRNA00214|U-UBE3A-ATS|UBE3A-AS|UBE3A-AS1|UBE3A-ATS|UBE3AATS-
Cytomap('SNHG14')('FUNDC1')

15q11.2

Xp11.3

Type of genencRNAprotein-coding
DescriptionUBE3A antisense RNA 1 (non-protein coding)UBE3A antisense transcriptlarge noncoding antisense transcriptsmall nucleolar RNA host gene 14 (non-protein coding)FUN14 domain-containing protein 1
Modification date2020030320200313
UniProtAcc.

Q8IVP5

Ensembl transtripts involved in fusion geneENST00000452731, ENST00000363358, 
ENST00000365067, ENST00000365306, 
ENST00000384430, ENST00000384733, 
ENST00000390982, ENST00000414175, 
ENST00000424208, ENST00000424333, 
ENST00000441592, ENST00000450809, 
ENST00000453082, ENST00000456576, 
ENST00000459433, ENST00000516123, 
ENST00000546682, ENST00000547292, 
ENST00000549804, ENST00000551077, 
ENST00000551361, ENST00000551631, 
ENST00000551938, ENST00000553108, 
ENST00000553134, ENST00000553149, 
ENST00000554726, ENST00000580438, 
Fusion gene scores* DoF score24 X 26 X 4=24966 X 5 X 4=120
# samples 277
** MAII scorelog2(27/2496*10)=-3.20858662181142
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(7/120*10)=-0.777607578663552
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SNHG14 [Title/Abstract] AND FUNDC1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointSNHG14(25512191)-FUNDC1(44386611), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneFUNDC1

GO:0000422

autophagy of mitochondrion

22267086

TgeneFUNDC1

GO:0001666

response to hypoxia

22267086



check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4PRADTCGA-TP-A8TT-01ASNHG14chr15

25512191

+FUNDC1chrX

44386611

-


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Fusion Gene ORF analysis for SNHG14-FUNDC1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000452731ENST00000378045SNHG14chr15

25512191

+FUNDC1chrX

44386611

-
3UTR-5UTRENST00000452731ENST00000483115SNHG14chr15

25512191

+FUNDC1chrX

44386611

-
intron-3CDSENST00000363358ENST00000378045SNHG14chr15

25512191

+FUNDC1chrX

44386611

-
intron-3CDSENST00000365067ENST00000378045SNHG14chr15

25512191

+FUNDC1chrX

44386611

-
intron-3CDSENST00000365306ENST00000378045SNHG14chr15

25512191

+FUNDC1chrX

44386611

-
intron-3CDSENST00000384430ENST00000378045SNHG14chr15

25512191

+FUNDC1chrX

44386611

-
intron-3CDSENST00000384733ENST00000378045SNHG14chr15

25512191

+FUNDC1chrX

44386611

-
intron-3CDSENST00000390982ENST00000378045SNHG14chr15

25512191

+FUNDC1chrX

44386611

-
intron-3CDSENST00000414175ENST00000378045SNHG14chr15

25512191

+FUNDC1chrX

44386611

-
intron-3CDSENST00000424208ENST00000378045SNHG14chr15

25512191

+FUNDC1chrX

44386611

-
intron-3CDSENST00000424333ENST00000378045SNHG14chr15

25512191

+FUNDC1chrX

44386611

-
intron-3CDSENST00000441592ENST00000378045SNHG14chr15

25512191

+FUNDC1chrX

44386611

-
intron-3CDSENST00000450809ENST00000378045SNHG14chr15

25512191

+FUNDC1chrX

44386611

-
intron-3CDSENST00000453082ENST00000378045SNHG14chr15

25512191

+FUNDC1chrX

44386611

-
intron-3CDSENST00000456576ENST00000378045SNHG14chr15

25512191

+FUNDC1chrX

44386611

-
intron-3CDSENST00000459433ENST00000378045SNHG14chr15

25512191

+FUNDC1chrX

44386611

-
intron-3CDSENST00000516123ENST00000378045SNHG14chr15

25512191

+FUNDC1chrX

44386611

-
intron-3CDSENST00000546682ENST00000378045SNHG14chr15

25512191

+FUNDC1chrX

44386611

-
intron-3CDSENST00000547292ENST00000378045SNHG14chr15

25512191

+FUNDC1chrX

44386611

-
intron-3CDSENST00000549804ENST00000378045SNHG14chr15

25512191

+FUNDC1chrX

44386611

-
intron-3CDSENST00000551077ENST00000378045SNHG14chr15

25512191

+FUNDC1chrX

44386611

-
intron-3CDSENST00000551361ENST00000378045SNHG14chr15

25512191

+FUNDC1chrX

44386611

-
intron-3CDSENST00000551631ENST00000378045SNHG14chr15

25512191

+FUNDC1chrX

44386611

-
intron-3CDSENST00000551938ENST00000378045SNHG14chr15

25512191

+FUNDC1chrX

44386611

-
intron-3CDSENST00000553108ENST00000378045SNHG14chr15

25512191

+FUNDC1chrX

44386611

-
intron-3CDSENST00000553134ENST00000378045SNHG14chr15

25512191

+FUNDC1chrX

44386611

-
intron-3CDSENST00000553149ENST00000378045SNHG14chr15

25512191

+FUNDC1chrX

44386611

-
intron-3CDSENST00000554726ENST00000378045SNHG14chr15

25512191

+FUNDC1chrX

44386611

-
intron-3CDSENST00000580438ENST00000378045SNHG14chr15

25512191

+FUNDC1chrX

44386611

-
intron-5UTRENST00000363358ENST00000483115SNHG14chr15

25512191

+FUNDC1chrX

44386611

-
intron-5UTRENST00000365067ENST00000483115SNHG14chr15

25512191

+FUNDC1chrX

44386611

-
intron-5UTRENST00000365306ENST00000483115SNHG14chr15

25512191

+FUNDC1chrX

44386611

-
intron-5UTRENST00000384430ENST00000483115SNHG14chr15

25512191

+FUNDC1chrX

44386611

-
intron-5UTRENST00000384733ENST00000483115SNHG14chr15

25512191

+FUNDC1chrX

44386611

-
intron-5UTRENST00000390982ENST00000483115SNHG14chr15

25512191

+FUNDC1chrX

44386611

-
intron-5UTRENST00000414175ENST00000483115SNHG14chr15

25512191

+FUNDC1chrX

44386611

-
intron-5UTRENST00000424208ENST00000483115SNHG14chr15

25512191

+FUNDC1chrX

44386611

-
intron-5UTRENST00000424333ENST00000483115SNHG14chr15

25512191

+FUNDC1chrX

44386611

-
intron-5UTRENST00000441592ENST00000483115SNHG14chr15

25512191

+FUNDC1chrX

44386611

-
intron-5UTRENST00000450809ENST00000483115SNHG14chr15

25512191

+FUNDC1chrX

44386611

-
intron-5UTRENST00000453082ENST00000483115SNHG14chr15

25512191

+FUNDC1chrX

44386611

-
intron-5UTRENST00000456576ENST00000483115SNHG14chr15

25512191

+FUNDC1chrX

44386611

-
intron-5UTRENST00000459433ENST00000483115SNHG14chr15

25512191

+FUNDC1chrX

44386611

-
intron-5UTRENST00000516123ENST00000483115SNHG14chr15

25512191

+FUNDC1chrX

44386611

-
intron-5UTRENST00000546682ENST00000483115SNHG14chr15

25512191

+FUNDC1chrX

44386611

-
intron-5UTRENST00000547292ENST00000483115SNHG14chr15

25512191

+FUNDC1chrX

44386611

-
intron-5UTRENST00000549804ENST00000483115SNHG14chr15

25512191

+FUNDC1chrX

44386611

-
intron-5UTRENST00000551077ENST00000483115SNHG14chr15

25512191

+FUNDC1chrX

44386611

-
intron-5UTRENST00000551361ENST00000483115SNHG14chr15

25512191

+FUNDC1chrX

44386611

-
intron-5UTRENST00000551631ENST00000483115SNHG14chr15

25512191

+FUNDC1chrX

44386611

-
intron-5UTRENST00000551938ENST00000483115SNHG14chr15

25512191

+FUNDC1chrX

44386611

-
intron-5UTRENST00000553108ENST00000483115SNHG14chr15

25512191

+FUNDC1chrX

44386611

-
intron-5UTRENST00000553134ENST00000483115SNHG14chr15

25512191

+FUNDC1chrX

44386611

-
intron-5UTRENST00000553149ENST00000483115SNHG14chr15

25512191

+FUNDC1chrX

44386611

-
intron-5UTRENST00000554726ENST00000483115SNHG14chr15

25512191

+FUNDC1chrX

44386611

-
intron-5UTRENST00000580438ENST00000483115SNHG14chr15

25512191

+FUNDC1chrX

44386611

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for SNHG14-FUNDC1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)


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Fusion Protein Features for SNHG14-FUNDC1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:25512191/:44386611)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.FUNDC1

Q8IVP5

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Acts as an activator of hypoxia-induced mitophagy, an important mechanism for mitochondrial quality control. {ECO:0000269|PubMed:22267086}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for SNHG14-FUNDC1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for SNHG14-FUNDC1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for SNHG14-FUNDC1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for SNHG14-FUNDC1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource