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	Fusion Gene Summary
	Fusion Gene ORF analysis
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Fusion gene:BAIAP2-LRP5 (FusionGDB2 ID:HG10458TG4041)

Fusion Gene Summary for BAIAP2-LRP5

Fusion gene summary

Fusion gene information	Fusion gene name: BAIAP2-LRP5
	Fusion gene ID: hg10458tg4041
		Hgene	Tgene
	Gene symbol	BAIAP2	LRP5
	Gene ID	10458	4041
	Gene name	BAR/IMD domain containing adaptor protein 2	LDL receptor related protein 5
	Synonyms	BAP2\|FLAF3\|IRSP53\|WAML	BMND1\|EVR1\|EVR4\|HBM\|LR3\|LRP-5\|LRP-7\|LRP7\|OPPG\|OPS\|OPTA1\|PCLD4\|VBCH2
	Cytomap	('BAIAP2')('LRP5') 17q25.3	11q13.2
	Type of gene	protein-coding	protein-coding
	Description	brain-specific angiogenesis inhibitor 1-associated protein 2BAI1 associated protein 2IRS-58IRSp53/58WASP and MIM likefas ligand-associated factor 3insulin receptor substrate of 53 kDainsulin receptor substrate p53/p58insulin receptor substrate pro	low-density lipoprotein receptor-related protein 5low density lipoprotein receptor-related protein 5low density lipoprotein receptor-related protein 7
	Modification date	20200327	20200329
	UniProtAcc	Q9UQB8	.
	Ensembl transtripts involved in fusion gene	ENST00000573894, ENST00000321280, ENST00000321300, ENST00000428708, ENST00000435091, ENST00000575245, ENST00000575712, ENST00000392411, ENST00000416299,
Fusion gene scores	* DoF score	6 X 6 X 7=252	17 X 23 X 10=3910
	# samples	10	27
	** MAII score	log2(10/252*10)=-1.33342373372519 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(27/3910*10)=-3.85613729514388 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: BAIAP2 [Title/Abstract] AND LRP5 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	BAIAP2(79031767)-LRP5(68181157), # samples:1
Anticipated loss of major functional domain due to fusion event.	BAIAP2-LRP5 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. BAIAP2-LRP5 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. BAIAP2-LRP5 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. BAIAP2-LRP5 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	LRP5	GO:0008284	positive regulation of cell proliferation	9790987
Tgene	LRP5	GO:0045840	positive regulation of mitotic nuclear division	9790987
Tgene	LRP5	GO:0045893	positive regulation of transcription, DNA-templated	15035989\|17955262
Tgene	LRP5	GO:0045944	positive regulation of transcription by RNA polymerase II	12857724
Tgene	LRP5	GO:0060070	canonical Wnt signaling pathway	11029007\|12121999\|12857724\|15908424\|24706814\|25920554

Fusion gene breakpoints across BAIAP2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across LRP5 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	UCEC	TCGA-D1-A16I-01A	BAIAP2	chr17	79031767	+	LRP5	chr11	68181157	+

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Fusion Gene ORF analysis for BAIAP2-LRP5

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
3UTR-3CDS	ENST00000573894	ENST00000294304	BAIAP2	chr17	79031767	+	LRP5	chr11	68181157	+
3UTR-intron	ENST00000573894	ENST00000529481	BAIAP2	chr17	79031767	+	LRP5	chr11	68181157	+
5CDS-intron	ENST00000321280	ENST00000529481	BAIAP2	chr17	79031767	+	LRP5	chr11	68181157	+
5CDS-intron	ENST00000321300	ENST00000529481	BAIAP2	chr17	79031767	+	LRP5	chr11	68181157	+
5CDS-intron	ENST00000428708	ENST00000529481	BAIAP2	chr17	79031767	+	LRP5	chr11	68181157	+
5CDS-intron	ENST00000435091	ENST00000529481	BAIAP2	chr17	79031767	+	LRP5	chr11	68181157	+
5CDS-intron	ENST00000575245	ENST00000529481	BAIAP2	chr17	79031767	+	LRP5	chr11	68181157	+
5CDS-intron	ENST00000575712	ENST00000529481	BAIAP2	chr17	79031767	+	LRP5	chr11	68181157	+
In-frame	ENST00000321280	ENST00000294304	BAIAP2	chr17	79031767	+	LRP5	chr11	68181157	+
In-frame	ENST00000321300	ENST00000294304	BAIAP2	chr17	79031767	+	LRP5	chr11	68181157	+
In-frame	ENST00000428708	ENST00000294304	BAIAP2	chr17	79031767	+	LRP5	chr11	68181157	+
In-frame	ENST00000435091	ENST00000294304	BAIAP2	chr17	79031767	+	LRP5	chr11	68181157	+
In-frame	ENST00000575245	ENST00000294304	BAIAP2	chr17	79031767	+	LRP5	chr11	68181157	+
In-frame	ENST00000575712	ENST00000294304	BAIAP2	chr17	79031767	+	LRP5	chr11	68181157	+
intron-3CDS	ENST00000392411	ENST00000294304	BAIAP2	chr17	79031767	+	LRP5	chr11	68181157	+
intron-3CDS	ENST00000416299	ENST00000294304	BAIAP2	chr17	79031767	+	LRP5	chr11	68181157	+
intron-intron	ENST00000392411	ENST00000529481	BAIAP2	chr17	79031767	+	LRP5	chr11	68181157	+
intron-intron	ENST00000416299	ENST00000529481	BAIAP2	chr17	79031767	+	LRP5	chr11	68181157	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000321280	BAIAP2	chr17	79031767	+	ENST00000294304	LRP5	chr11	68181157	+	2871	321	59	2665	868
ENST00000428708	BAIAP2	chr17	79031767	+	ENST00000294304	LRP5	chr11	68181157	+	2871	321	59	2665	868
ENST00000575712	BAIAP2	chr17	79031767	+	ENST00000294304	LRP5	chr11	68181157	+	2866	316	54	2660	868
ENST00000575245	BAIAP2	chr17	79031767	+	ENST00000294304	LRP5	chr11	68181157	+	2963	413	52	2757	901
ENST00000435091	BAIAP2	chr17	79031767	+	ENST00000294304	LRP5	chr11	68181157	+	2860	310	48	2654	868
ENST00000321300	BAIAP2	chr17	79031767	+	ENST00000294304	LRP5	chr11	68181157	+	2860	310	48	2654	868

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000321280	ENST00000294304	BAIAP2	chr17	79031767	+	LRP5	chr11	68181157	+	0.005041765	0.9949582
ENST00000428708	ENST00000294304	BAIAP2	chr17	79031767	+	LRP5	chr11	68181157	+	0.005041765	0.9949582
ENST00000575712	ENST00000294304	BAIAP2	chr17	79031767	+	LRP5	chr11	68181157	+	0.005208842	0.99479115
ENST00000575245	ENST00000294304	BAIAP2	chr17	79031767	+	LRP5	chr11	68181157	+	0.003331536	0.9966685
ENST00000435091	ENST00000294304	BAIAP2	chr17	79031767	+	LRP5	chr11	68181157	+	0.005304461	0.9946956
ENST00000321300	ENST00000294304	BAIAP2	chr17	79031767	+	LRP5	chr11	68181157	+	0.005304461	0.9946956

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Fusion Genomic Features for BAIAP2-LRP5

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
BAIAP2	chr17	79031767	+	LRP5	chr11	68181156	+	1.20E-06	0.9999988
BAIAP2	chr17	79031767	+	LRP5	chr11	68181156	+	1.20E-06	0.9999988

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for BAIAP2-LRP5

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr17:79031767/chr11:68181157)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
BAIAP2 Q9UQB8	.
FUNCTION: Adapter protein that links membrane-bound small G-proteins to cytoplasmic effector proteins. Necessary for CDC42-mediated reorganization of the actin cytoskeleton and for RAC1-mediated membrane ruffling. Involved in the regulation of the actin cytoskeleton by WASF family members and the Arp2/3 complex. Plays a role in neurite growth. Acts syngeristically with ENAH to promote filipodia formation. Plays a role in the reorganization of the actin cytoskeleton in response to bacterial infection. Participates in actin bundling when associated with EPS8, promoting filopodial protrusions. {ECO:0000269\|PubMed:11130076, ECO:0000269\|PubMed:11696321, ECO:0000269\|PubMed:14752106, ECO:0000269\|PubMed:17115031, ECO:0000269\|PubMed:19366662}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

LRP5

chr17:79031767

chr11:68181157

ENST00000294304

1495_1610

834

1616.0

Compositional bias

Note=Pro-rich

Tgene

LRP5

chr17:79031767

chr11:68181157

ENST00000294304

1213_1254

834

1616.0

Domain

Note=EGF-like 4

Tgene

LRP5

chr17:79031767

chr11:68181157

ENST00000294304

1258_1296

834

1616.0

Domain

LDL-receptor class A 1

Tgene

LRP5

chr17:79031767

chr11:68181157

ENST00000294304

1297_1333

834

1616.0

Domain

LDL-receptor class A 2

Tgene

LRP5

chr17:79031767

chr11:68181157

ENST00000294304

1335_1371

834

1616.0

Domain

LDL-receptor class A 3

Tgene

LRP5

chr17:79031767

chr11:68181157

ENST00000294304

902_942

834

1616.0

Domain

Note=EGF-like 3

Tgene

LRP5

chr17:79031767

chr11:68181157

ENST00000294304

1500_1506

834

1616.0

Motif

Note=PPPSP motif A

Tgene

LRP5

chr17:79031767

chr11:68181157

ENST00000294304

1538_1545

834

1616.0

Motif

Note=PPPSP motif B

Tgene

LRP5

chr17:79031767

chr11:68181157

ENST00000294304

1574_1581

834

1616.0

Motif

Note=PPPSP motif C

Tgene

LRP5

chr17:79031767

chr11:68181157

ENST00000294304

1591_1596

834

1616.0

Motif

Note=PPPSP motif D

Tgene

LRP5

chr17:79031767

chr11:68181157

ENST00000294304

1605_1612

834

1616.0

Motif

Note=PPPSP motif E

Tgene

LRP5

chr17:79031767

chr11:68181157

ENST00000294304

945_1212

834

1616.0

Region

Note=Beta-propeller 4

Tgene

LRP5

chr17:79031767

chr11:68181157

ENST00000294304

1036_1078

834

1616.0

Repeat

Note=LDL-receptor class B 17

Tgene

LRP5

chr17:79031767

chr11:68181157

ENST00000294304

1079_1123

834

1616.0

Repeat

Note=LDL-receptor class B 18

Tgene

LRP5

chr17:79031767

chr11:68181157

ENST00000294304

1124_1164

834

1616.0

Repeat

Note=LDL-receptor class B 19

Tgene

LRP5

chr17:79031767

chr11:68181157

ENST00000294304

1165_1207

834

1616.0

Repeat

Note=LDL-receptor class B 20

Tgene

LRP5

chr17:79031767

chr11:68181157

ENST00000294304

856_898

834

1616.0

Repeat

Note=LDL-receptor class B 15

Tgene

LRP5

chr17:79031767

chr11:68181157

ENST00000294304

859_862

834

1616.0

Repeat

Note=YWTD 11

Tgene

LRP5

chr17:79031767

chr11:68181157

ENST00000294304

989_1035

834

1616.0

Repeat

Note=LDL-receptor class B 16

Tgene

LRP5

chr17:79031767

chr11:68181157

ENST00000294304

1408_1615

834

1616.0

Topological domain

Cytoplasmic

Tgene

LRP5

chr17:79031767

chr11:68181157

ENST00000294304

1385_1407

834

1616.0

Transmembrane

Helical

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

BAIAP2

chr17:79031767

chr11:68181157

ENST00000321280

132_153

522.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

BAIAP2

chr17:79031767

chr11:68181157

ENST00000321300

132_153

553.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

BAIAP2

chr17:79031767

chr11:68181157

ENST00000428708

132_153

535.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

BAIAP2

chr17:79031767

chr11:68181157

ENST00000435091

132_153

623.6666666666666

Coiled coil

Ontology_term=ECO:0000255

Hgene

BAIAP2

chr17:79031767

chr11:68181157

ENST00000575712

132_153

513.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

BAIAP2

chr17:79031767

chr11:68181157

ENST00000321280

1_250

522.0

Domain

IMD

Hgene

BAIAP2

chr17:79031767

chr11:68181157

ENST00000321280

374_437

522.0

Domain

SH3

Hgene

BAIAP2

chr17:79031767

chr11:68181157

ENST00000321300

1_250

553.0

Domain

IMD

Hgene

BAIAP2

chr17:79031767

chr11:68181157

ENST00000321300

374_437

553.0

Domain

SH3

Hgene

BAIAP2

chr17:79031767

chr11:68181157

ENST00000428708

1_250

535.0

Domain

IMD

Hgene

BAIAP2

chr17:79031767

chr11:68181157

ENST00000428708

374_437

535.0

Domain

SH3

Hgene

BAIAP2

chr17:79031767

chr11:68181157

ENST00000435091

1_250

623.6666666666666

Domain

IMD

Hgene

BAIAP2

chr17:79031767

chr11:68181157

ENST00000435091

374_437

623.6666666666666

Domain

SH3

Hgene

BAIAP2

chr17:79031767

chr11:68181157

ENST00000575712

1_250

513.0

Domain

IMD

Hgene

BAIAP2

chr17:79031767

chr11:68181157

ENST00000575712

374_437

513.0

Domain

SH3

Tgene

LRP5

chr17:79031767

chr11:68181157

ENST00000294304

295_337

834

1616.0

Domain

Note=EGF-like 1

Tgene

LRP5

chr17:79031767

chr11:68181157

ENST00000294304

601_641

834

1616.0

Domain

Note=EGF-like 2

Tgene

LRP5

chr17:79031767

chr11:68181157

ENST00000294304

32_288

834

1616.0

Region

Note=Beta-propeller 1

Tgene

LRP5

chr17:79031767

chr11:68181157

ENST00000294304

341_602

834

1616.0

Region

Note=Beta-propeller 2

Tgene

LRP5

chr17:79031767

chr11:68181157

ENST00000294304

644_903

834

1616.0

Region

Note=Beta-propeller 3

Tgene

LRP5

chr17:79031767

chr11:68181157

ENST00000294304

120_162

834

1616.0

Repeat

Note=LDL-receptor class B 2

Tgene

LRP5

chr17:79031767

chr11:68181157

ENST00000294304

123_126

834

1616.0

Repeat

Note=YWTD 2

Tgene

LRP5

chr17:79031767

chr11:68181157

ENST00000294304

163_206

834

1616.0

Repeat

Note=LDL-receptor class B 3

Tgene

LRP5

chr17:79031767

chr11:68181157

ENST00000294304

166_169

834

1616.0

Repeat

Note=YWTD 3

Tgene

LRP5

chr17:79031767

chr11:68181157

ENST00000294304

207_247

834

1616.0

Repeat

Note=LDL-receptor class B 4

Tgene

LRP5

chr17:79031767

chr11:68181157

ENST00000294304

248_290

834

1616.0

Repeat

Note=LDL-receptor class B 5

Tgene

LRP5

chr17:79031767

chr11:68181157

ENST00000294304

251_254

834

1616.0

Repeat

Note=YWTD 4

Tgene

LRP5

chr17:79031767

chr11:68181157

ENST00000294304

385_427

834

1616.0

Repeat

Note=LDL-receptor class B 6

Tgene

LRP5

chr17:79031767

chr11:68181157

ENST00000294304

388_391

834

1616.0

Repeat

Note=YWTD 5

Tgene

LRP5

chr17:79031767

chr11:68181157

ENST00000294304

428_470

834

1616.0

Repeat

Note=LDL-receptor class B 7

Tgene

LRP5

chr17:79031767

chr11:68181157

ENST00000294304

431_434

834

1616.0

Repeat

Note=YWTD 6

Tgene

LRP5

chr17:79031767

chr11:68181157

ENST00000294304

471_514

834

1616.0

Repeat

Note=LDL-receptor class B 8

Tgene

LRP5

chr17:79031767

chr11:68181157

ENST00000294304

474_477

834

1616.0

Repeat

Note=YWTD 7

Tgene

LRP5

chr17:79031767

chr11:68181157

ENST00000294304

515_557

834

1616.0

Repeat

Note=LDL-receptor class B 9

Tgene

LRP5

chr17:79031767

chr11:68181157

ENST00000294304

558_600

834

1616.0

Repeat

Note=LDL-receptor class B 10

Tgene

LRP5

chr17:79031767

chr11:68181157

ENST00000294304

559_562

834

1616.0

Repeat

Note=YWTD 8

Tgene

LRP5

chr17:79031767

chr11:68181157

ENST00000294304

687_729

834

1616.0

Repeat

Note=LDL-receptor class B 11

Tgene

LRP5

chr17:79031767

chr11:68181157

ENST00000294304

690_693

834

1616.0

Repeat

Note=YWTD 9

Tgene

LRP5

chr17:79031767

chr11:68181157

ENST00000294304

730_772

834

1616.0

Repeat

Note=LDL-receptor class B 12

Tgene

LRP5

chr17:79031767

chr11:68181157

ENST00000294304

75_119

834

1616.0

Repeat

Note=LDL-receptor class B 1

Tgene

LRP5

chr17:79031767

chr11:68181157

ENST00000294304

773_815

834

1616.0

Repeat

Note=LDL-receptor class B 13

Tgene

LRP5

chr17:79031767

chr11:68181157

ENST00000294304

78_81

834

1616.0

Repeat

Note=YWTD 1

Tgene

LRP5

chr17:79031767

chr11:68181157

ENST00000294304

816_855

834

1616.0

Repeat

Note=LDL-receptor class B 14

Tgene

LRP5

chr17:79031767

chr11:68181157

ENST00000294304

819_822

834

1616.0

Repeat

Note=YWTD 10

Tgene

LRP5

chr17:79031767

chr11:68181157

ENST00000294304

32_1384

834

1616.0

Topological domain

Extracellular

Top

Fusion Gene Sequence for BAIAP2-LRP5

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>8934_8934_1_BAIAP2-LRP5_BAIAP2_chr17_79031767_ENST00000321280_LRP5_chr11_68181157_ENST00000294304_length(transcript)=2871nt_BP=321nt
GTGGTTCGGGTCCGCTTTCGTCTCCGTCCTGCTGCCGTTACCGCCGCTGCTGCCGCCGCTTGCGTCCCCCGCTCCGGTCTGTGGTGCAGC
CGGGACCCAGGACCATGTCTCTGTCTCGCTCAGAGGAGATGCACCGGCTCACGGAAAATGTCTATAAGACCATCATGGAGCAGTTCAACC
CTAGCCTCCGGAACTTCATCGCCATGGGGAAGAATTACGAGAAGGCACTGGCAGGTGTGACGTATGCAGCCAAAGGCTACTTTGACGCCC
TGGTGAAGATGGGGGAGCTGGCCAGCGAGAGCCAGGGCTCCAAAGAACTCGGTCAGGAGCGGGTCGTGATTGCCGACGATCTCCCGCACC
CGTTCGGTCTGACGCAGTACAGCGATTATATCTACTGGACAGACTGGAATCTGCACAGCATTGAGCGGGCCGACAAGACTAGCGGCCGGA
ACCGCACCCTCATCCAGGGCCACCTGGACTTCGTGATGGACATCCTGGTGTTCCACTCCTCCCGCCAGGATGGCCTCAATGACTGTATGC
ACAACAACGGGCAGTGTGGGCAGCTGTGCCTTGCCATCCCCGGCGGCCACCGCTGCGGCTGCGCCTCACACTACACCCTGGACCCCAGCA
GCCGCAACTGCAGCCCGCCCACCACCTTCTTGCTGTTCAGCCAGAAATCTGCCATCAGTCGGATGATCCCGGACGACCAGCACAGCCCGG
ATCTCATCCTGCCCCTGCATGGACTGAGGAACGTCAAAGCCATCGACTATGACCCACTGGACAAGTTCATCTACTGGGTGGATGGGCGCC
AGAACATCAAGCGAGCCAAGGACGACGGGACCCAGCCCTTTGTTTTGACCTCTCTGAGCCAAGGCCAAAACCCAGACAGGCAGCCCCACG
ACCTCAGCATCGACATCTACAGCCGGACACTGTTCTGGACGTGCGAGGCCACCAATACCATCAACGTCCACAGGCTGAGCGGGGAAGCCA
TGGGGGTGGTGCTGCGTGGGGACCGCGACAAGCCCAGGGCCATCGTCGTCAACGCGGAGCGAGGGTACCTGTACTTCACCAACATGCAGG
ACCGGGCAGCCAAGATCGAACGCGCAGCCCTGGACGGCACCGAGCGCGAGGTCCTCTTCACCACCGGCCTCATCCGCCCTGTGGCCCTGG
TGGTGGACAACACACTGGGCAAGCTGTTCTGGGTGGACGCGGACCTGAAGCGCATTGAGAGCTGTGACCTGTCAGGGGCCAACCGCCTGA
CCCTGGAGGACGCCAACATCGTGCAGCCTCTGGGCCTGACCATCCTTGGCAAGCATCTCTACTGGATCGACCGCCAGCAGCAGATGATCG
AGCGTGTGGAGAAGACCACCGGGGACAAGCGGACTCGCATCCAGGGCCGTGTCGCCCACCTCACTGGCATCCATGCAGTGGAGGAAGTCA
GCCTGGAGGAGTTCTCAGCCCACCCATGTGCCCGTGACAATGGTGGCTGCTCCCACATCTGTATTGCCAAGGGTGATGGGACACCACGGT
GCTCATGCCCAGTCCACCTCGTGCTCCTGCAGAACCTGCTGACCTGTGGAGAGCCGCCCACCTGCTCCCCGGACCAGTTTGCATGTGCCA
CAGGGGAGATCGACTGTATCCCCGGGGCCTGGCGCTGTGACGGCTTTCCCGAGTGCGATGACCAGAGCGACGAGGAGGGCTGCCCCGTGT
GCTCCGCCGCCCAGTTCCCCTGCGCGCGGGGTCAGTGTGTGGACCTGCGCCTGCGCTGCGACGGCGAGGCAGACTGTCAGGACCGCTCAG
ACGAGGCGGACTGTGACGCCATCTGCCTGCCCAACCAGTTCCGGTGTGCGAGCGGCCAGTGTGTCCTCATCAAACAGCAGTGCGACTCCT
TCCCCGACTGTATCGACGGCTCCGACGAGCTCATGTGTGAAATCACCAAGCCGCCCTCAGACGACAGCCCGGCCCACAGCAGTGCCATCG
GGCCCGTCATTGGCATCATCCTCTCTCTCTTCGTCATGGGTGGTGTCTATTTTGTGTGCCAGCGCGTGGTGTGCCAGCGCTATGCGGGGG
CCAACGGGCCCTTCCCGCACGAGTATGTCAGCGGGACCCCGCACGTGCCCCTCAATTTCATAGCCCCGGGCGGTTCCCAGCATGGCCCCT
TCACAGGCATCGCATGCGGAAAGTCCATGATGAGCTCCGTGAGCCTGATGGGGGGCCGGGGCGGGGTGCCCCTCTACGACCGGAACCACG
TCACAGGGGCCTCGTCCAGCAGCTCGTCCAGCACGAAGGCCACGCTGTACCCGCCGATCCTGAACCCGCCGCCCTCCCCGGCCACGGACC
CCTCCCTGTACAACATGGACATGTTCTACTCTTCAAACATTCCGGCCACTGCGAGACCGTACAGGCCCTACATCATTCGAGGAATGGCGC
CCCCGACGACGCCCTGCAGCACCGACGTGTGTGACAGCGACTACAGCGCCAGCCGCTGGAAGGCCAGCAAGTACTACCTGGATTTGAACT
CGGACTCAGACCCCTATCCACCCCCACCCACGCCCCACAGCCAGTACCTGTCGGCGGAGGACAGCTGCCCGCCCTCGCCCGCCACCGAGA
GGAGCTACTTCCATCTCTTCCCGCCCCCTCCGTCCCCCTGCACGGACTCATCCTGACCTCGGCCGGGCCACTCTGGCTTCTCTGTGCCCC
TGTAAATAGTTTTAAATATGAACAAAGAAAAAAATATATTTTATGATTTAAAAAATAAATATAATTGGGATTTTAAAAACATGAGAAATG
TGAACTGTGATGGGGTGGGCAGGGCTGGGAGAACTTTGTACAGTGGAGAAATATTTATAAACTTAATTTTGTAAAACAGAA

>8934_8934_1_BAIAP2-LRP5_BAIAP2_chr17_79031767_ENST00000321280_LRP5_chr11_68181157_ENST00000294304_length(amino acids)=868AA_BP=87
MRPPLRSVVQPGPRTMSLSRSEEMHRLTENVYKTIMEQFNPSLRNFIAMGKNYEKALAGVTYAAKGYFDALVKMGELASESQGSKELGQE
RVVIADDLPHPFGLTQYSDYIYWTDWNLHSIERADKTSGRNRTLIQGHLDFVMDILVFHSSRQDGLNDCMHNNGQCGQLCLAIPGGHRCG
CASHYTLDPSSRNCSPPTTFLLFSQKSAISRMIPDDQHSPDLILPLHGLRNVKAIDYDPLDKFIYWVDGRQNIKRAKDDGTQPFVLTSLS
QGQNPDRQPHDLSIDIYSRTLFWTCEATNTINVHRLSGEAMGVVLRGDRDKPRAIVVNAERGYLYFTNMQDRAAKIERAALDGTEREVLF
TTGLIRPVALVVDNTLGKLFWVDADLKRIESCDLSGANRLTLEDANIVQPLGLTILGKHLYWIDRQQQMIERVEKTTGDKRTRIQGRVAH
LTGIHAVEEVSLEEFSAHPCARDNGGCSHICIAKGDGTPRCSCPVHLVLLQNLLTCGEPPTCSPDQFACATGEIDCIPGAWRCDGFPECD
DQSDEEGCPVCSAAQFPCARGQCVDLRLRCDGEADCQDRSDEADCDAICLPNQFRCASGQCVLIKQQCDSFPDCIDGSDELMCEITKPPS
DDSPAHSSAIGPVIGIILSLFVMGGVYFVCQRVVCQRYAGANGPFPHEYVSGTPHVPLNFIAPGGSQHGPFTGIACGKSMMSSVSLMGGR
GGVPLYDRNHVTGASSSSSSSTKATLYPPILNPPPSPATDPSLYNMDMFYSSNIPATARPYRPYIIRGMAPPTTPCSTDVCDSDYSASRW
KASKYYLDLNSDSDPYPPPPTPHSQYLSAEDSCPPSPATERSYFHLFPPPPSPCTDSS

--------------------------------------------------------------
>8934_8934_2_BAIAP2-LRP5_BAIAP2_chr17_79031767_ENST00000321300_LRP5_chr11_68181157_ENST00000294304_length(transcript)=2860nt_BP=310nt
CCGCTTTCGTCTCCGTCCTGCTGCCGTTACCGCCGCTGCTGCCGCCGCTTGCGTCCCCCGCTCCGGTCTGTGGTGCAGCCGGGACCCAGG
ACCATGTCTCTGTCTCGCTCAGAGGAGATGCACCGGCTCACGGAAAATGTCTATAAGACCATCATGGAGCAGTTCAACCCTAGCCTCCGG
AACTTCATCGCCATGGGGAAGAATTACGAGAAGGCACTGGCAGGTGTGACGTATGCAGCCAAAGGCTACTTTGACGCCCTGGTGAAGATG
GGGGAGCTGGCCAGCGAGAGCCAGGGCTCCAAAGAACTCGGTCAGGAGCGGGTCGTGATTGCCGACGATCTCCCGCACCCGTTCGGTCTG
ACGCAGTACAGCGATTATATCTACTGGACAGACTGGAATCTGCACAGCATTGAGCGGGCCGACAAGACTAGCGGCCGGAACCGCACCCTC
ATCCAGGGCCACCTGGACTTCGTGATGGACATCCTGGTGTTCCACTCCTCCCGCCAGGATGGCCTCAATGACTGTATGCACAACAACGGG
CAGTGTGGGCAGCTGTGCCTTGCCATCCCCGGCGGCCACCGCTGCGGCTGCGCCTCACACTACACCCTGGACCCCAGCAGCCGCAACTGC
AGCCCGCCCACCACCTTCTTGCTGTTCAGCCAGAAATCTGCCATCAGTCGGATGATCCCGGACGACCAGCACAGCCCGGATCTCATCCTG
CCCCTGCATGGACTGAGGAACGTCAAAGCCATCGACTATGACCCACTGGACAAGTTCATCTACTGGGTGGATGGGCGCCAGAACATCAAG
CGAGCCAAGGACGACGGGACCCAGCCCTTTGTTTTGACCTCTCTGAGCCAAGGCCAAAACCCAGACAGGCAGCCCCACGACCTCAGCATC
GACATCTACAGCCGGACACTGTTCTGGACGTGCGAGGCCACCAATACCATCAACGTCCACAGGCTGAGCGGGGAAGCCATGGGGGTGGTG
CTGCGTGGGGACCGCGACAAGCCCAGGGCCATCGTCGTCAACGCGGAGCGAGGGTACCTGTACTTCACCAACATGCAGGACCGGGCAGCC
AAGATCGAACGCGCAGCCCTGGACGGCACCGAGCGCGAGGTCCTCTTCACCACCGGCCTCATCCGCCCTGTGGCCCTGGTGGTGGACAAC
ACACTGGGCAAGCTGTTCTGGGTGGACGCGGACCTGAAGCGCATTGAGAGCTGTGACCTGTCAGGGGCCAACCGCCTGACCCTGGAGGAC
GCCAACATCGTGCAGCCTCTGGGCCTGACCATCCTTGGCAAGCATCTCTACTGGATCGACCGCCAGCAGCAGATGATCGAGCGTGTGGAG
AAGACCACCGGGGACAAGCGGACTCGCATCCAGGGCCGTGTCGCCCACCTCACTGGCATCCATGCAGTGGAGGAAGTCAGCCTGGAGGAG
TTCTCAGCCCACCCATGTGCCCGTGACAATGGTGGCTGCTCCCACATCTGTATTGCCAAGGGTGATGGGACACCACGGTGCTCATGCCCA
GTCCACCTCGTGCTCCTGCAGAACCTGCTGACCTGTGGAGAGCCGCCCACCTGCTCCCCGGACCAGTTTGCATGTGCCACAGGGGAGATC
GACTGTATCCCCGGGGCCTGGCGCTGTGACGGCTTTCCCGAGTGCGATGACCAGAGCGACGAGGAGGGCTGCCCCGTGTGCTCCGCCGCC
CAGTTCCCCTGCGCGCGGGGTCAGTGTGTGGACCTGCGCCTGCGCTGCGACGGCGAGGCAGACTGTCAGGACCGCTCAGACGAGGCGGAC
TGTGACGCCATCTGCCTGCCCAACCAGTTCCGGTGTGCGAGCGGCCAGTGTGTCCTCATCAAACAGCAGTGCGACTCCTTCCCCGACTGT
ATCGACGGCTCCGACGAGCTCATGTGTGAAATCACCAAGCCGCCCTCAGACGACAGCCCGGCCCACAGCAGTGCCATCGGGCCCGTCATT
GGCATCATCCTCTCTCTCTTCGTCATGGGTGGTGTCTATTTTGTGTGCCAGCGCGTGGTGTGCCAGCGCTATGCGGGGGCCAACGGGCCC
TTCCCGCACGAGTATGTCAGCGGGACCCCGCACGTGCCCCTCAATTTCATAGCCCCGGGCGGTTCCCAGCATGGCCCCTTCACAGGCATC
GCATGCGGAAAGTCCATGATGAGCTCCGTGAGCCTGATGGGGGGCCGGGGCGGGGTGCCCCTCTACGACCGGAACCACGTCACAGGGGCC
TCGTCCAGCAGCTCGTCCAGCACGAAGGCCACGCTGTACCCGCCGATCCTGAACCCGCCGCCCTCCCCGGCCACGGACCCCTCCCTGTAC
AACATGGACATGTTCTACTCTTCAAACATTCCGGCCACTGCGAGACCGTACAGGCCCTACATCATTCGAGGAATGGCGCCCCCGACGACG
CCCTGCAGCACCGACGTGTGTGACAGCGACTACAGCGCCAGCCGCTGGAAGGCCAGCAAGTACTACCTGGATTTGAACTCGGACTCAGAC
CCCTATCCACCCCCACCCACGCCCCACAGCCAGTACCTGTCGGCGGAGGACAGCTGCCCGCCCTCGCCCGCCACCGAGAGGAGCTACTTC
CATCTCTTCCCGCCCCCTCCGTCCCCCTGCACGGACTCATCCTGACCTCGGCCGGGCCACTCTGGCTTCTCTGTGCCCCTGTAAATAGTT
TTAAATATGAACAAAGAAAAAAATATATTTTATGATTTAAAAAATAAATATAATTGGGATTTTAAAAACATGAGAAATGTGAACTGTGAT
GGGGTGGGCAGGGCTGGGAGAACTTTGTACAGTGGAGAAATATTTATAAACTTAATTTTGTAAAACAGAA

>8934_8934_2_BAIAP2-LRP5_BAIAP2_chr17_79031767_ENST00000321300_LRP5_chr11_68181157_ENST00000294304_length(amino acids)=868AA_BP=87
MRPPLRSVVQPGPRTMSLSRSEEMHRLTENVYKTIMEQFNPSLRNFIAMGKNYEKALAGVTYAAKGYFDALVKMGELASESQGSKELGQE
RVVIADDLPHPFGLTQYSDYIYWTDWNLHSIERADKTSGRNRTLIQGHLDFVMDILVFHSSRQDGLNDCMHNNGQCGQLCLAIPGGHRCG
CASHYTLDPSSRNCSPPTTFLLFSQKSAISRMIPDDQHSPDLILPLHGLRNVKAIDYDPLDKFIYWVDGRQNIKRAKDDGTQPFVLTSLS
QGQNPDRQPHDLSIDIYSRTLFWTCEATNTINVHRLSGEAMGVVLRGDRDKPRAIVVNAERGYLYFTNMQDRAAKIERAALDGTEREVLF
TTGLIRPVALVVDNTLGKLFWVDADLKRIESCDLSGANRLTLEDANIVQPLGLTILGKHLYWIDRQQQMIERVEKTTGDKRTRIQGRVAH
LTGIHAVEEVSLEEFSAHPCARDNGGCSHICIAKGDGTPRCSCPVHLVLLQNLLTCGEPPTCSPDQFACATGEIDCIPGAWRCDGFPECD
DQSDEEGCPVCSAAQFPCARGQCVDLRLRCDGEADCQDRSDEADCDAICLPNQFRCASGQCVLIKQQCDSFPDCIDGSDELMCEITKPPS
DDSPAHSSAIGPVIGIILSLFVMGGVYFVCQRVVCQRYAGANGPFPHEYVSGTPHVPLNFIAPGGSQHGPFTGIACGKSMMSSVSLMGGR
GGVPLYDRNHVTGASSSSSSSTKATLYPPILNPPPSPATDPSLYNMDMFYSSNIPATARPYRPYIIRGMAPPTTPCSTDVCDSDYSASRW
KASKYYLDLNSDSDPYPPPPTPHSQYLSAEDSCPPSPATERSYFHLFPPPPSPCTDSS

--------------------------------------------------------------
>8934_8934_3_BAIAP2-LRP5_BAIAP2_chr17_79031767_ENST00000428708_LRP5_chr11_68181157_ENST00000294304_length(transcript)=2871nt_BP=321nt
GTGGTTCGGGTCCGCTTTCGTCTCCGTCCTGCTGCCGTTACCGCCGCTGCTGCCGCCGCTTGCGTCCCCCGCTCCGGTCTGTGGTGCAGC
CGGGACCCAGGACCATGTCTCTGTCTCGCTCAGAGGAGATGCACCGGCTCACGGAAAATGTCTATAAGACCATCATGGAGCAGTTCAACC
CTAGCCTCCGGAACTTCATCGCCATGGGGAAGAATTACGAGAAGGCACTGGCAGGTGTGACGTATGCAGCCAAAGGCTACTTTGACGCCC
TGGTGAAGATGGGGGAGCTGGCCAGCGAGAGCCAGGGCTCCAAAGAACTCGGTCAGGAGCGGGTCGTGATTGCCGACGATCTCCCGCACC
CGTTCGGTCTGACGCAGTACAGCGATTATATCTACTGGACAGACTGGAATCTGCACAGCATTGAGCGGGCCGACAAGACTAGCGGCCGGA
ACCGCACCCTCATCCAGGGCCACCTGGACTTCGTGATGGACATCCTGGTGTTCCACTCCTCCCGCCAGGATGGCCTCAATGACTGTATGC
ACAACAACGGGCAGTGTGGGCAGCTGTGCCTTGCCATCCCCGGCGGCCACCGCTGCGGCTGCGCCTCACACTACACCCTGGACCCCAGCA
GCCGCAACTGCAGCCCGCCCACCACCTTCTTGCTGTTCAGCCAGAAATCTGCCATCAGTCGGATGATCCCGGACGACCAGCACAGCCCGG
ATCTCATCCTGCCCCTGCATGGACTGAGGAACGTCAAAGCCATCGACTATGACCCACTGGACAAGTTCATCTACTGGGTGGATGGGCGCC
AGAACATCAAGCGAGCCAAGGACGACGGGACCCAGCCCTTTGTTTTGACCTCTCTGAGCCAAGGCCAAAACCCAGACAGGCAGCCCCACG
ACCTCAGCATCGACATCTACAGCCGGACACTGTTCTGGACGTGCGAGGCCACCAATACCATCAACGTCCACAGGCTGAGCGGGGAAGCCA
TGGGGGTGGTGCTGCGTGGGGACCGCGACAAGCCCAGGGCCATCGTCGTCAACGCGGAGCGAGGGTACCTGTACTTCACCAACATGCAGG
ACCGGGCAGCCAAGATCGAACGCGCAGCCCTGGACGGCACCGAGCGCGAGGTCCTCTTCACCACCGGCCTCATCCGCCCTGTGGCCCTGG
TGGTGGACAACACACTGGGCAAGCTGTTCTGGGTGGACGCGGACCTGAAGCGCATTGAGAGCTGTGACCTGTCAGGGGCCAACCGCCTGA
CCCTGGAGGACGCCAACATCGTGCAGCCTCTGGGCCTGACCATCCTTGGCAAGCATCTCTACTGGATCGACCGCCAGCAGCAGATGATCG
AGCGTGTGGAGAAGACCACCGGGGACAAGCGGACTCGCATCCAGGGCCGTGTCGCCCACCTCACTGGCATCCATGCAGTGGAGGAAGTCA
GCCTGGAGGAGTTCTCAGCCCACCCATGTGCCCGTGACAATGGTGGCTGCTCCCACATCTGTATTGCCAAGGGTGATGGGACACCACGGT
GCTCATGCCCAGTCCACCTCGTGCTCCTGCAGAACCTGCTGACCTGTGGAGAGCCGCCCACCTGCTCCCCGGACCAGTTTGCATGTGCCA
CAGGGGAGATCGACTGTATCCCCGGGGCCTGGCGCTGTGACGGCTTTCCCGAGTGCGATGACCAGAGCGACGAGGAGGGCTGCCCCGTGT
GCTCCGCCGCCCAGTTCCCCTGCGCGCGGGGTCAGTGTGTGGACCTGCGCCTGCGCTGCGACGGCGAGGCAGACTGTCAGGACCGCTCAG
ACGAGGCGGACTGTGACGCCATCTGCCTGCCCAACCAGTTCCGGTGTGCGAGCGGCCAGTGTGTCCTCATCAAACAGCAGTGCGACTCCT
TCCCCGACTGTATCGACGGCTCCGACGAGCTCATGTGTGAAATCACCAAGCCGCCCTCAGACGACAGCCCGGCCCACAGCAGTGCCATCG
GGCCCGTCATTGGCATCATCCTCTCTCTCTTCGTCATGGGTGGTGTCTATTTTGTGTGCCAGCGCGTGGTGTGCCAGCGCTATGCGGGGG
CCAACGGGCCCTTCCCGCACGAGTATGTCAGCGGGACCCCGCACGTGCCCCTCAATTTCATAGCCCCGGGCGGTTCCCAGCATGGCCCCT
TCACAGGCATCGCATGCGGAAAGTCCATGATGAGCTCCGTGAGCCTGATGGGGGGCCGGGGCGGGGTGCCCCTCTACGACCGGAACCACG
TCACAGGGGCCTCGTCCAGCAGCTCGTCCAGCACGAAGGCCACGCTGTACCCGCCGATCCTGAACCCGCCGCCCTCCCCGGCCACGGACC
CCTCCCTGTACAACATGGACATGTTCTACTCTTCAAACATTCCGGCCACTGCGAGACCGTACAGGCCCTACATCATTCGAGGAATGGCGC
CCCCGACGACGCCCTGCAGCACCGACGTGTGTGACAGCGACTACAGCGCCAGCCGCTGGAAGGCCAGCAAGTACTACCTGGATTTGAACT
CGGACTCAGACCCCTATCCACCCCCACCCACGCCCCACAGCCAGTACCTGTCGGCGGAGGACAGCTGCCCGCCCTCGCCCGCCACCGAGA
GGAGCTACTTCCATCTCTTCCCGCCCCCTCCGTCCCCCTGCACGGACTCATCCTGACCTCGGCCGGGCCACTCTGGCTTCTCTGTGCCCC
TGTAAATAGTTTTAAATATGAACAAAGAAAAAAATATATTTTATGATTTAAAAAATAAATATAATTGGGATTTTAAAAACATGAGAAATG
TGAACTGTGATGGGGTGGGCAGGGCTGGGAGAACTTTGTACAGTGGAGAAATATTTATAAACTTAATTTTGTAAAACAGAA

>8934_8934_3_BAIAP2-LRP5_BAIAP2_chr17_79031767_ENST00000428708_LRP5_chr11_68181157_ENST00000294304_length(amino acids)=868AA_BP=87
MRPPLRSVVQPGPRTMSLSRSEEMHRLTENVYKTIMEQFNPSLRNFIAMGKNYEKALAGVTYAAKGYFDALVKMGELASESQGSKELGQE
RVVIADDLPHPFGLTQYSDYIYWTDWNLHSIERADKTSGRNRTLIQGHLDFVMDILVFHSSRQDGLNDCMHNNGQCGQLCLAIPGGHRCG
CASHYTLDPSSRNCSPPTTFLLFSQKSAISRMIPDDQHSPDLILPLHGLRNVKAIDYDPLDKFIYWVDGRQNIKRAKDDGTQPFVLTSLS
QGQNPDRQPHDLSIDIYSRTLFWTCEATNTINVHRLSGEAMGVVLRGDRDKPRAIVVNAERGYLYFTNMQDRAAKIERAALDGTEREVLF
TTGLIRPVALVVDNTLGKLFWVDADLKRIESCDLSGANRLTLEDANIVQPLGLTILGKHLYWIDRQQQMIERVEKTTGDKRTRIQGRVAH
LTGIHAVEEVSLEEFSAHPCARDNGGCSHICIAKGDGTPRCSCPVHLVLLQNLLTCGEPPTCSPDQFACATGEIDCIPGAWRCDGFPECD
DQSDEEGCPVCSAAQFPCARGQCVDLRLRCDGEADCQDRSDEADCDAICLPNQFRCASGQCVLIKQQCDSFPDCIDGSDELMCEITKPPS
DDSPAHSSAIGPVIGIILSLFVMGGVYFVCQRVVCQRYAGANGPFPHEYVSGTPHVPLNFIAPGGSQHGPFTGIACGKSMMSSVSLMGGR
GGVPLYDRNHVTGASSSSSSSTKATLYPPILNPPPSPATDPSLYNMDMFYSSNIPATARPYRPYIIRGMAPPTTPCSTDVCDSDYSASRW
KASKYYLDLNSDSDPYPPPPTPHSQYLSAEDSCPPSPATERSYFHLFPPPPSPCTDSS

--------------------------------------------------------------
>8934_8934_4_BAIAP2-LRP5_BAIAP2_chr17_79031767_ENST00000435091_LRP5_chr11_68181157_ENST00000294304_length(transcript)=2860nt_BP=310nt
CCGCTTTCGTCTCCGTCCTGCTGCCGTTACCGCCGCTGCTGCCGCCGCTTGCGTCCCCCGCTCCGGTCTGTGGTGCAGCCGGGACCCAGG
ACCATGTCTCTGTCTCGCTCAGAGGAGATGCACCGGCTCACGGAAAATGTCTATAAGACCATCATGGAGCAGTTCAACCCTAGCCTCCGG
AACTTCATCGCCATGGGGAAGAATTACGAGAAGGCACTGGCAGGTGTGACGTATGCAGCCAAAGGCTACTTTGACGCCCTGGTGAAGATG
GGGGAGCTGGCCAGCGAGAGCCAGGGCTCCAAAGAACTCGGTCAGGAGCGGGTCGTGATTGCCGACGATCTCCCGCACCCGTTCGGTCTG
ACGCAGTACAGCGATTATATCTACTGGACAGACTGGAATCTGCACAGCATTGAGCGGGCCGACAAGACTAGCGGCCGGAACCGCACCCTC
ATCCAGGGCCACCTGGACTTCGTGATGGACATCCTGGTGTTCCACTCCTCCCGCCAGGATGGCCTCAATGACTGTATGCACAACAACGGG
CAGTGTGGGCAGCTGTGCCTTGCCATCCCCGGCGGCCACCGCTGCGGCTGCGCCTCACACTACACCCTGGACCCCAGCAGCCGCAACTGC
AGCCCGCCCACCACCTTCTTGCTGTTCAGCCAGAAATCTGCCATCAGTCGGATGATCCCGGACGACCAGCACAGCCCGGATCTCATCCTG
CCCCTGCATGGACTGAGGAACGTCAAAGCCATCGACTATGACCCACTGGACAAGTTCATCTACTGGGTGGATGGGCGCCAGAACATCAAG
CGAGCCAAGGACGACGGGACCCAGCCCTTTGTTTTGACCTCTCTGAGCCAAGGCCAAAACCCAGACAGGCAGCCCCACGACCTCAGCATC
GACATCTACAGCCGGACACTGTTCTGGACGTGCGAGGCCACCAATACCATCAACGTCCACAGGCTGAGCGGGGAAGCCATGGGGGTGGTG
CTGCGTGGGGACCGCGACAAGCCCAGGGCCATCGTCGTCAACGCGGAGCGAGGGTACCTGTACTTCACCAACATGCAGGACCGGGCAGCC
AAGATCGAACGCGCAGCCCTGGACGGCACCGAGCGCGAGGTCCTCTTCACCACCGGCCTCATCCGCCCTGTGGCCCTGGTGGTGGACAAC
ACACTGGGCAAGCTGTTCTGGGTGGACGCGGACCTGAAGCGCATTGAGAGCTGTGACCTGTCAGGGGCCAACCGCCTGACCCTGGAGGAC
GCCAACATCGTGCAGCCTCTGGGCCTGACCATCCTTGGCAAGCATCTCTACTGGATCGACCGCCAGCAGCAGATGATCGAGCGTGTGGAG
AAGACCACCGGGGACAAGCGGACTCGCATCCAGGGCCGTGTCGCCCACCTCACTGGCATCCATGCAGTGGAGGAAGTCAGCCTGGAGGAG
TTCTCAGCCCACCCATGTGCCCGTGACAATGGTGGCTGCTCCCACATCTGTATTGCCAAGGGTGATGGGACACCACGGTGCTCATGCCCA
GTCCACCTCGTGCTCCTGCAGAACCTGCTGACCTGTGGAGAGCCGCCCACCTGCTCCCCGGACCAGTTTGCATGTGCCACAGGGGAGATC
GACTGTATCCCCGGGGCCTGGCGCTGTGACGGCTTTCCCGAGTGCGATGACCAGAGCGACGAGGAGGGCTGCCCCGTGTGCTCCGCCGCC
CAGTTCCCCTGCGCGCGGGGTCAGTGTGTGGACCTGCGCCTGCGCTGCGACGGCGAGGCAGACTGTCAGGACCGCTCAGACGAGGCGGAC
TGTGACGCCATCTGCCTGCCCAACCAGTTCCGGTGTGCGAGCGGCCAGTGTGTCCTCATCAAACAGCAGTGCGACTCCTTCCCCGACTGT
ATCGACGGCTCCGACGAGCTCATGTGTGAAATCACCAAGCCGCCCTCAGACGACAGCCCGGCCCACAGCAGTGCCATCGGGCCCGTCATT
GGCATCATCCTCTCTCTCTTCGTCATGGGTGGTGTCTATTTTGTGTGCCAGCGCGTGGTGTGCCAGCGCTATGCGGGGGCCAACGGGCCC
TTCCCGCACGAGTATGTCAGCGGGACCCCGCACGTGCCCCTCAATTTCATAGCCCCGGGCGGTTCCCAGCATGGCCCCTTCACAGGCATC
GCATGCGGAAAGTCCATGATGAGCTCCGTGAGCCTGATGGGGGGCCGGGGCGGGGTGCCCCTCTACGACCGGAACCACGTCACAGGGGCC
TCGTCCAGCAGCTCGTCCAGCACGAAGGCCACGCTGTACCCGCCGATCCTGAACCCGCCGCCCTCCCCGGCCACGGACCCCTCCCTGTAC
AACATGGACATGTTCTACTCTTCAAACATTCCGGCCACTGCGAGACCGTACAGGCCCTACATCATTCGAGGAATGGCGCCCCCGACGACG
CCCTGCAGCACCGACGTGTGTGACAGCGACTACAGCGCCAGCCGCTGGAAGGCCAGCAAGTACTACCTGGATTTGAACTCGGACTCAGAC
CCCTATCCACCCCCACCCACGCCCCACAGCCAGTACCTGTCGGCGGAGGACAGCTGCCCGCCCTCGCCCGCCACCGAGAGGAGCTACTTC
CATCTCTTCCCGCCCCCTCCGTCCCCCTGCACGGACTCATCCTGACCTCGGCCGGGCCACTCTGGCTTCTCTGTGCCCCTGTAAATAGTT
TTAAATATGAACAAAGAAAAAAATATATTTTATGATTTAAAAAATAAATATAATTGGGATTTTAAAAACATGAGAAATGTGAACTGTGAT
GGGGTGGGCAGGGCTGGGAGAACTTTGTACAGTGGAGAAATATTTATAAACTTAATTTTGTAAAACAGAA

>8934_8934_4_BAIAP2-LRP5_BAIAP2_chr17_79031767_ENST00000435091_LRP5_chr11_68181157_ENST00000294304_length(amino acids)=868AA_BP=87
MRPPLRSVVQPGPRTMSLSRSEEMHRLTENVYKTIMEQFNPSLRNFIAMGKNYEKALAGVTYAAKGYFDALVKMGELASESQGSKELGQE
RVVIADDLPHPFGLTQYSDYIYWTDWNLHSIERADKTSGRNRTLIQGHLDFVMDILVFHSSRQDGLNDCMHNNGQCGQLCLAIPGGHRCG
CASHYTLDPSSRNCSPPTTFLLFSQKSAISRMIPDDQHSPDLILPLHGLRNVKAIDYDPLDKFIYWVDGRQNIKRAKDDGTQPFVLTSLS
QGQNPDRQPHDLSIDIYSRTLFWTCEATNTINVHRLSGEAMGVVLRGDRDKPRAIVVNAERGYLYFTNMQDRAAKIERAALDGTEREVLF
TTGLIRPVALVVDNTLGKLFWVDADLKRIESCDLSGANRLTLEDANIVQPLGLTILGKHLYWIDRQQQMIERVEKTTGDKRTRIQGRVAH
LTGIHAVEEVSLEEFSAHPCARDNGGCSHICIAKGDGTPRCSCPVHLVLLQNLLTCGEPPTCSPDQFACATGEIDCIPGAWRCDGFPECD
DQSDEEGCPVCSAAQFPCARGQCVDLRLRCDGEADCQDRSDEADCDAICLPNQFRCASGQCVLIKQQCDSFPDCIDGSDELMCEITKPPS
DDSPAHSSAIGPVIGIILSLFVMGGVYFVCQRVVCQRYAGANGPFPHEYVSGTPHVPLNFIAPGGSQHGPFTGIACGKSMMSSVSLMGGR
GGVPLYDRNHVTGASSSSSSSTKATLYPPILNPPPSPATDPSLYNMDMFYSSNIPATARPYRPYIIRGMAPPTTPCSTDVCDSDYSASRW
KASKYYLDLNSDSDPYPPPPTPHSQYLSAEDSCPPSPATERSYFHLFPPPPSPCTDSS

--------------------------------------------------------------
>8934_8934_5_BAIAP2-LRP5_BAIAP2_chr17_79031767_ENST00000575245_LRP5_chr11_68181157_ENST00000294304_length(transcript)=2963nt_BP=413nt
GGGTCCGCTTTCGTCTCCGTCCTGCTGCCGTTACCGCCGCTGCTGCCGCCGCTTGCGTCCCCCGCTCCGGTCTGTGGTGCAGCCGGGACC
CAGGACCATGTCTCTGTCTCGCTCAGAGGAGATGCACCGGCTCACGGAAAATGTCTATAAGAGGGTGGAAGAGAAGTACCAGCGGAACCT
TTTTCCTATTTTTTCTCCTTCTGCGCTGAAACCAGAAAGCAGGAACTTTCGTGGTGAGAGTTGGCAGGGGACCATCATGGAGCAGTTCAA
CCCTAGCCTCCGGAACTTCATCGCCATGGGGAAGAATTACGAGAAGGCACTGGCAGGTGTGACGTATGCAGCCAAAGGCTACTTTGACGC
CCTGGTGAAGATGGGGGAGCTGGCCAGCGAGAGCCAGGGCTCCAAAGAACTCGGTCAGGAGCGGGTCGTGATTGCCGACGATCTCCCGCA
CCCGTTCGGTCTGACGCAGTACAGCGATTATATCTACTGGACAGACTGGAATCTGCACAGCATTGAGCGGGCCGACAAGACTAGCGGCCG
GAACCGCACCCTCATCCAGGGCCACCTGGACTTCGTGATGGACATCCTGGTGTTCCACTCCTCCCGCCAGGATGGCCTCAATGACTGTAT
GCACAACAACGGGCAGTGTGGGCAGCTGTGCCTTGCCATCCCCGGCGGCCACCGCTGCGGCTGCGCCTCACACTACACCCTGGACCCCAG
CAGCCGCAACTGCAGCCCGCCCACCACCTTCTTGCTGTTCAGCCAGAAATCTGCCATCAGTCGGATGATCCCGGACGACCAGCACAGCCC
GGATCTCATCCTGCCCCTGCATGGACTGAGGAACGTCAAAGCCATCGACTATGACCCACTGGACAAGTTCATCTACTGGGTGGATGGGCG
CCAGAACATCAAGCGAGCCAAGGACGACGGGACCCAGCCCTTTGTTTTGACCTCTCTGAGCCAAGGCCAAAACCCAGACAGGCAGCCCCA
CGACCTCAGCATCGACATCTACAGCCGGACACTGTTCTGGACGTGCGAGGCCACCAATACCATCAACGTCCACAGGCTGAGCGGGGAAGC
CATGGGGGTGGTGCTGCGTGGGGACCGCGACAAGCCCAGGGCCATCGTCGTCAACGCGGAGCGAGGGTACCTGTACTTCACCAACATGCA
GGACCGGGCAGCCAAGATCGAACGCGCAGCCCTGGACGGCACCGAGCGCGAGGTCCTCTTCACCACCGGCCTCATCCGCCCTGTGGCCCT
GGTGGTGGACAACACACTGGGCAAGCTGTTCTGGGTGGACGCGGACCTGAAGCGCATTGAGAGCTGTGACCTGTCAGGGGCCAACCGCCT
GACCCTGGAGGACGCCAACATCGTGCAGCCTCTGGGCCTGACCATCCTTGGCAAGCATCTCTACTGGATCGACCGCCAGCAGCAGATGAT
CGAGCGTGTGGAGAAGACCACCGGGGACAAGCGGACTCGCATCCAGGGCCGTGTCGCCCACCTCACTGGCATCCATGCAGTGGAGGAAGT
CAGCCTGGAGGAGTTCTCAGCCCACCCATGTGCCCGTGACAATGGTGGCTGCTCCCACATCTGTATTGCCAAGGGTGATGGGACACCACG
GTGCTCATGCCCAGTCCACCTCGTGCTCCTGCAGAACCTGCTGACCTGTGGAGAGCCGCCCACCTGCTCCCCGGACCAGTTTGCATGTGC
CACAGGGGAGATCGACTGTATCCCCGGGGCCTGGCGCTGTGACGGCTTTCCCGAGTGCGATGACCAGAGCGACGAGGAGGGCTGCCCCGT
GTGCTCCGCCGCCCAGTTCCCCTGCGCGCGGGGTCAGTGTGTGGACCTGCGCCTGCGCTGCGACGGCGAGGCAGACTGTCAGGACCGCTC
AGACGAGGCGGACTGTGACGCCATCTGCCTGCCCAACCAGTTCCGGTGTGCGAGCGGCCAGTGTGTCCTCATCAAACAGCAGTGCGACTC
CTTCCCCGACTGTATCGACGGCTCCGACGAGCTCATGTGTGAAATCACCAAGCCGCCCTCAGACGACAGCCCGGCCCACAGCAGTGCCAT
CGGGCCCGTCATTGGCATCATCCTCTCTCTCTTCGTCATGGGTGGTGTCTATTTTGTGTGCCAGCGCGTGGTGTGCCAGCGCTATGCGGG
GGCCAACGGGCCCTTCCCGCACGAGTATGTCAGCGGGACCCCGCACGTGCCCCTCAATTTCATAGCCCCGGGCGGTTCCCAGCATGGCCC
CTTCACAGGCATCGCATGCGGAAAGTCCATGATGAGCTCCGTGAGCCTGATGGGGGGCCGGGGCGGGGTGCCCCTCTACGACCGGAACCA
CGTCACAGGGGCCTCGTCCAGCAGCTCGTCCAGCACGAAGGCCACGCTGTACCCGCCGATCCTGAACCCGCCGCCCTCCCCGGCCACGGA
CCCCTCCCTGTACAACATGGACATGTTCTACTCTTCAAACATTCCGGCCACTGCGAGACCGTACAGGCCCTACATCATTCGAGGAATGGC
GCCCCCGACGACGCCCTGCAGCACCGACGTGTGTGACAGCGACTACAGCGCCAGCCGCTGGAAGGCCAGCAAGTACTACCTGGATTTGAA
CTCGGACTCAGACCCCTATCCACCCCCACCCACGCCCCACAGCCAGTACCTGTCGGCGGAGGACAGCTGCCCGCCCTCGCCCGCCACCGA
GAGGAGCTACTTCCATCTCTTCCCGCCCCCTCCGTCCCCCTGCACGGACTCATCCTGACCTCGGCCGGGCCACTCTGGCTTCTCTGTGCC
CCTGTAAATAGTTTTAAATATGAACAAAGAAAAAAATATATTTTATGATTTAAAAAATAAATATAATTGGGATTTTAAAAACATGAGAAA
TGTGAACTGTGATGGGGTGGGCAGGGCTGGGAGAACTTTGTACAGTGGAGAAATATTTATAAACTTAATTTTGTAAAACAGAA

>8934_8934_5_BAIAP2-LRP5_BAIAP2_chr17_79031767_ENST00000575245_LRP5_chr11_68181157_ENST00000294304_length(amino acids)=901AA_BP=120
MRPPLRSVVQPGPRTMSLSRSEEMHRLTENVYKRVEEKYQRNLFPIFSPSALKPESRNFRGESWQGTIMEQFNPSLRNFIAMGKNYEKAL
AGVTYAAKGYFDALVKMGELASESQGSKELGQERVVIADDLPHPFGLTQYSDYIYWTDWNLHSIERADKTSGRNRTLIQGHLDFVMDILV
FHSSRQDGLNDCMHNNGQCGQLCLAIPGGHRCGCASHYTLDPSSRNCSPPTTFLLFSQKSAISRMIPDDQHSPDLILPLHGLRNVKAIDY
DPLDKFIYWVDGRQNIKRAKDDGTQPFVLTSLSQGQNPDRQPHDLSIDIYSRTLFWTCEATNTINVHRLSGEAMGVVLRGDRDKPRAIVV
NAERGYLYFTNMQDRAAKIERAALDGTEREVLFTTGLIRPVALVVDNTLGKLFWVDADLKRIESCDLSGANRLTLEDANIVQPLGLTILG
KHLYWIDRQQQMIERVEKTTGDKRTRIQGRVAHLTGIHAVEEVSLEEFSAHPCARDNGGCSHICIAKGDGTPRCSCPVHLVLLQNLLTCG
EPPTCSPDQFACATGEIDCIPGAWRCDGFPECDDQSDEEGCPVCSAAQFPCARGQCVDLRLRCDGEADCQDRSDEADCDAICLPNQFRCA
SGQCVLIKQQCDSFPDCIDGSDELMCEITKPPSDDSPAHSSAIGPVIGIILSLFVMGGVYFVCQRVVCQRYAGANGPFPHEYVSGTPHVP
LNFIAPGGSQHGPFTGIACGKSMMSSVSLMGGRGGVPLYDRNHVTGASSSSSSSTKATLYPPILNPPPSPATDPSLYNMDMFYSSNIPAT
ARPYRPYIIRGMAPPTTPCSTDVCDSDYSASRWKASKYYLDLNSDSDPYPPPPTPHSQYLSAEDSCPPSPATERSYFHLFPPPPSPCTDS
S

--------------------------------------------------------------
>8934_8934_6_BAIAP2-LRP5_BAIAP2_chr17_79031767_ENST00000575712_LRP5_chr11_68181157_ENST00000294304_length(transcript)=2866nt_BP=316nt
TCGGGTCCGCTTTCGTCTCCGTCCTGCTGCCGTTACCGCCGCTGCTGCCGCCGCTTGCGTCCCCCGCTCCGGTCTGTGGTGCAGCCGGGA
CCCAGGACCATGTCTCTGTCTCGCTCAGAGGAGATGCACCGGCTCACGGAAAATGTCTATAAGACCATCATGGAGCAGTTCAACCCTAGC
CTCCGGAACTTCATCGCCATGGGGAAGAATTACGAGAAGGCACTGGCAGGTGTGACGTATGCAGCCAAAGGCTACTTTGACGCCCTGGTG
AAGATGGGGGAGCTGGCCAGCGAGAGCCAGGGCTCCAAAGAACTCGGTCAGGAGCGGGTCGTGATTGCCGACGATCTCCCGCACCCGTTC
GGTCTGACGCAGTACAGCGATTATATCTACTGGACAGACTGGAATCTGCACAGCATTGAGCGGGCCGACAAGACTAGCGGCCGGAACCGC
ACCCTCATCCAGGGCCACCTGGACTTCGTGATGGACATCCTGGTGTTCCACTCCTCCCGCCAGGATGGCCTCAATGACTGTATGCACAAC
AACGGGCAGTGTGGGCAGCTGTGCCTTGCCATCCCCGGCGGCCACCGCTGCGGCTGCGCCTCACACTACACCCTGGACCCCAGCAGCCGC
AACTGCAGCCCGCCCACCACCTTCTTGCTGTTCAGCCAGAAATCTGCCATCAGTCGGATGATCCCGGACGACCAGCACAGCCCGGATCTC
ATCCTGCCCCTGCATGGACTGAGGAACGTCAAAGCCATCGACTATGACCCACTGGACAAGTTCATCTACTGGGTGGATGGGCGCCAGAAC
ATCAAGCGAGCCAAGGACGACGGGACCCAGCCCTTTGTTTTGACCTCTCTGAGCCAAGGCCAAAACCCAGACAGGCAGCCCCACGACCTC
AGCATCGACATCTACAGCCGGACACTGTTCTGGACGTGCGAGGCCACCAATACCATCAACGTCCACAGGCTGAGCGGGGAAGCCATGGGG
GTGGTGCTGCGTGGGGACCGCGACAAGCCCAGGGCCATCGTCGTCAACGCGGAGCGAGGGTACCTGTACTTCACCAACATGCAGGACCGG
GCAGCCAAGATCGAACGCGCAGCCCTGGACGGCACCGAGCGCGAGGTCCTCTTCACCACCGGCCTCATCCGCCCTGTGGCCCTGGTGGTG
GACAACACACTGGGCAAGCTGTTCTGGGTGGACGCGGACCTGAAGCGCATTGAGAGCTGTGACCTGTCAGGGGCCAACCGCCTGACCCTG
GAGGACGCCAACATCGTGCAGCCTCTGGGCCTGACCATCCTTGGCAAGCATCTCTACTGGATCGACCGCCAGCAGCAGATGATCGAGCGT
GTGGAGAAGACCACCGGGGACAAGCGGACTCGCATCCAGGGCCGTGTCGCCCACCTCACTGGCATCCATGCAGTGGAGGAAGTCAGCCTG
GAGGAGTTCTCAGCCCACCCATGTGCCCGTGACAATGGTGGCTGCTCCCACATCTGTATTGCCAAGGGTGATGGGACACCACGGTGCTCA
TGCCCAGTCCACCTCGTGCTCCTGCAGAACCTGCTGACCTGTGGAGAGCCGCCCACCTGCTCCCCGGACCAGTTTGCATGTGCCACAGGG
GAGATCGACTGTATCCCCGGGGCCTGGCGCTGTGACGGCTTTCCCGAGTGCGATGACCAGAGCGACGAGGAGGGCTGCCCCGTGTGCTCC
GCCGCCCAGTTCCCCTGCGCGCGGGGTCAGTGTGTGGACCTGCGCCTGCGCTGCGACGGCGAGGCAGACTGTCAGGACCGCTCAGACGAG
GCGGACTGTGACGCCATCTGCCTGCCCAACCAGTTCCGGTGTGCGAGCGGCCAGTGTGTCCTCATCAAACAGCAGTGCGACTCCTTCCCC
GACTGTATCGACGGCTCCGACGAGCTCATGTGTGAAATCACCAAGCCGCCCTCAGACGACAGCCCGGCCCACAGCAGTGCCATCGGGCCC
GTCATTGGCATCATCCTCTCTCTCTTCGTCATGGGTGGTGTCTATTTTGTGTGCCAGCGCGTGGTGTGCCAGCGCTATGCGGGGGCCAAC
GGGCCCTTCCCGCACGAGTATGTCAGCGGGACCCCGCACGTGCCCCTCAATTTCATAGCCCCGGGCGGTTCCCAGCATGGCCCCTTCACA
GGCATCGCATGCGGAAAGTCCATGATGAGCTCCGTGAGCCTGATGGGGGGCCGGGGCGGGGTGCCCCTCTACGACCGGAACCACGTCACA
GGGGCCTCGTCCAGCAGCTCGTCCAGCACGAAGGCCACGCTGTACCCGCCGATCCTGAACCCGCCGCCCTCCCCGGCCACGGACCCCTCC
CTGTACAACATGGACATGTTCTACTCTTCAAACATTCCGGCCACTGCGAGACCGTACAGGCCCTACATCATTCGAGGAATGGCGCCCCCG
ACGACGCCCTGCAGCACCGACGTGTGTGACAGCGACTACAGCGCCAGCCGCTGGAAGGCCAGCAAGTACTACCTGGATTTGAACTCGGAC
TCAGACCCCTATCCACCCCCACCCACGCCCCACAGCCAGTACCTGTCGGCGGAGGACAGCTGCCCGCCCTCGCCCGCCACCGAGAGGAGC
TACTTCCATCTCTTCCCGCCCCCTCCGTCCCCCTGCACGGACTCATCCTGACCTCGGCCGGGCCACTCTGGCTTCTCTGTGCCCCTGTAA
ATAGTTTTAAATATGAACAAAGAAAAAAATATATTTTATGATTTAAAAAATAAATATAATTGGGATTTTAAAAACATGAGAAATGTGAAC
TGTGATGGGGTGGGCAGGGCTGGGAGAACTTTGTACAGTGGAGAAATATTTATAAACTTAATTTTGTAAAACAGAA

>8934_8934_6_BAIAP2-LRP5_BAIAP2_chr17_79031767_ENST00000575712_LRP5_chr11_68181157_ENST00000294304_length(amino acids)=868AA_BP=87
MRPPLRSVVQPGPRTMSLSRSEEMHRLTENVYKTIMEQFNPSLRNFIAMGKNYEKALAGVTYAAKGYFDALVKMGELASESQGSKELGQE
RVVIADDLPHPFGLTQYSDYIYWTDWNLHSIERADKTSGRNRTLIQGHLDFVMDILVFHSSRQDGLNDCMHNNGQCGQLCLAIPGGHRCG
CASHYTLDPSSRNCSPPTTFLLFSQKSAISRMIPDDQHSPDLILPLHGLRNVKAIDYDPLDKFIYWVDGRQNIKRAKDDGTQPFVLTSLS
QGQNPDRQPHDLSIDIYSRTLFWTCEATNTINVHRLSGEAMGVVLRGDRDKPRAIVVNAERGYLYFTNMQDRAAKIERAALDGTEREVLF
TTGLIRPVALVVDNTLGKLFWVDADLKRIESCDLSGANRLTLEDANIVQPLGLTILGKHLYWIDRQQQMIERVEKTTGDKRTRIQGRVAH
LTGIHAVEEVSLEEFSAHPCARDNGGCSHICIAKGDGTPRCSCPVHLVLLQNLLTCGEPPTCSPDQFACATGEIDCIPGAWRCDGFPECD
DQSDEEGCPVCSAAQFPCARGQCVDLRLRCDGEADCQDRSDEADCDAICLPNQFRCASGQCVLIKQQCDSFPDCIDGSDELMCEITKPPS
DDSPAHSSAIGPVIGIILSLFVMGGVYFVCQRVVCQRYAGANGPFPHEYVSGTPHVPLNFIAPGGSQHGPFTGIACGKSMMSSVSLMGGR
GGVPLYDRNHVTGASSSSSSSTKATLYPPILNPPPSPATDPSLYNMDMFYSSNIPATARPYRPYIIRGMAPPTTPCSTDVCDSDYSASRW
KASKYYLDLNSDSDPYPPPPTPHSQYLSAEDSCPPSPATERSYFHLFPPPPSPCTDSS

--------------------------------------------------------------

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Fusion Gene PPI Analysis for BAIAP2-LRP5

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for BAIAP2-LRP5

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for BAIAP2-LRP5

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Tgene		C1866176	EXUDATIVE VITREORETINOPATHY 4 (disorder)	10	CTD_human;GENOMICS_ENGLAND;UNIPROT
Tgene		C0432252	Osteoporosis with pseudoglioma	8	CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
Tgene		C1866079	BONE MINERAL DENSITY QUANTITATIVE TRAIT LOCUS 1	6	GENOMICS_ENGLAND;UNIPROT
Tgene		C1843330	OSTEOPETROSIS, AUTOSOMAL DOMINANT 1	4	CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
Tgene		C4693479	POLYCYSTIC LIVER DISEASE 4 WITH OR WITHOUT KIDNEY CYSTS	3	GENOMICS_ENGLAND;UNIPROT
Tgene		C0432273	Worth disease	2	CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
Tgene		C1843323	Van Buchem disease type 2	2	CTD_human;GENOMICS_ENGLAND;UNIPROT
Tgene		C0015397	Disorder of eye	1	GENOMICS_ENGLAND
Tgene		C0035344	Retinopathy of Prematurity	1	ORPHANET
Tgene		C0151879	Shortened QT interval	1	GENOMICS_ENGLAND
Tgene		C0158683	Polycystic liver disease	1	ORPHANET
Tgene		C0242852	Proliferative vitreoretinopathy	1	CTD_human
Tgene		C0339539	Familial Exudative Vitreoretinopathy	1	CTD_human
Tgene		C0432272	Van Buchem disease	1	ORPHANET
Tgene		C1851402	Exudative vitreoretinopathy 1	1	CTD_human;UNIPROT

Fusion Gene Studies in Kim Lab

Fusion gene:BAIAP2-LRP5 (FusionGDB2 ID:HG10458TG4041)

Fusion Gene Summary for BAIAP2-LRP5

Fusion Gene ORF analysis for BAIAP2-LRP5

Fusion Genomic Features for BAIAP2-LRP5

Fusion Protein Features for BAIAP2-LRP5

Fusion Gene Sequence for BAIAP2-LRP5

Fusion Gene PPI Analysis for BAIAP2-LRP5

Related Drugs for BAIAP2-LRP5

Related Diseases for BAIAP2-LRP5

Fusion Gene Studies
in Kim Lab