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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Fusion gene:CREB3-TMEM8B (FusionGDB2 ID:HG10488TG51754)

Fusion Gene Summary for CREB3-TMEM8B

check button Fusion gene summary
Fusion gene informationFusion gene name: CREB3-TMEM8B
Fusion gene ID: hg10488tg51754
HgeneTgene
Gene symbol

CREB3

TMEM8B

Gene ID

10488

51754

Gene namecAMP responsive element binding protein 3transmembrane protein 8B
SynonymsLUMAN|LZIP|sLZIPC9orf127|FP588|LINC00950|NAG-5|NAG5|NGX6|NGX6a
Cytomap('CREB3')('TMEM8B')

9p13.3

9p13.3

Type of geneprotein-codingprotein-coding
Descriptioncyclic AMP-responsive element-binding protein 3basic leucine zipper proteincyclic AMP response element (CRE)-binding protein/activating transcription factor 1leucin zipper proiteinsmall leucine zipper proteintranscription factor LZIP-alphatransmembrane protein 8Bnasopharyngeal carcinoma expressed 6nasopharyngeal carcinoma related proteinnasopharyngeal carcinoma-associated gene 6 protein
Modification date2020032020200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000486056, ENST00000353704, 
Fusion gene scores* DoF score4 X 4 X 3=485 X 4 X 5=100
# samples 67
** MAII scorelog2(6/48*10)=0.321928094887362
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(7/100*10)=-0.514573172829758
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CREB3 [Title/Abstract] AND TMEM8B [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCREB3(35733482)-TMEM8B(35845972), # samples:2
Anticipated loss of major functional domain due to fusion event.CREB3-TMEM8B seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
CREB3-TMEM8B seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
CREB3-TMEM8B seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
CREB3-TMEM8B seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCREB3

GO:0006990

positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response

16940180

HgeneCREB3

GO:0045944

positive regulation of transcription by RNA polymerase II

16940180|17296613

HgeneCREB3

GO:0090026

positive regulation of monocyte chemotaxis

17296613

HgeneCREB3

GO:1902236

negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway

16940180


check buttonFusion gene breakpoints across CREB3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across TMEM8B (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4PAADTCGA-IB-A5ST-01ACREB3chr9

35733482

+TMEM8Bchr9

35845972

+
ChimerDB4PAADTCGA-IB-A5STCREB3chr9

35733482

+TMEM8Bchr9

35845971

+
ChimerDB4PAADTCGA-IB-A5STCREB3chr9

35733482

+TMEM8Bchr9

35845972

+


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Fusion Gene ORF analysis for CREB3-TMEM8B

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000486056ENST00000377991CREB3chr9

35733482

+TMEM8Bchr9

35845972

+
3UTR-3CDSENST00000486056ENST00000377991CREB3chr9

35733482

+TMEM8Bchr9

35845971

+
3UTR-3CDSENST00000486056ENST00000377996CREB3chr9

35733482

+TMEM8Bchr9

35845972

+
3UTR-3CDSENST00000486056ENST00000377996CREB3chr9

35733482

+TMEM8Bchr9

35845971

+
3UTR-3CDSENST00000486056ENST00000439587CREB3chr9

35733482

+TMEM8Bchr9

35845972

+
3UTR-3CDSENST00000486056ENST00000439587CREB3chr9

35733482

+TMEM8Bchr9

35845971

+
3UTR-3UTRENST00000486056ENST00000377988CREB3chr9

35733482

+TMEM8Bchr9

35845972

+
3UTR-3UTRENST00000486056ENST00000377988CREB3chr9

35733482

+TMEM8Bchr9

35845971

+
3UTR-3UTRENST00000486056ENST00000473947CREB3chr9

35733482

+TMEM8Bchr9

35845972

+
3UTR-3UTRENST00000486056ENST00000473947CREB3chr9

35733482

+TMEM8Bchr9

35845971

+
5CDS-3UTRENST00000353704ENST00000377988CREB3chr9

35733482

+TMEM8Bchr9

35845972

+
5CDS-3UTRENST00000353704ENST00000377988CREB3chr9

35733482

+TMEM8Bchr9

35845971

+
5CDS-3UTRENST00000353704ENST00000473947CREB3chr9

35733482

+TMEM8Bchr9

35845972

+
5CDS-3UTRENST00000353704ENST00000473947CREB3chr9

35733482

+TMEM8Bchr9

35845971

+
In-frameENST00000353704ENST00000377991CREB3chr9

35733482

+TMEM8Bchr9

35845972

+
In-frameENST00000353704ENST00000377991CREB3chr9

35733482

+TMEM8Bchr9

35845971

+
In-frameENST00000353704ENST00000377996CREB3chr9

35733482

+TMEM8Bchr9

35845972

+
In-frameENST00000353704ENST00000377996CREB3chr9

35733482

+TMEM8Bchr9

35845971

+
In-frameENST00000353704ENST00000439587CREB3chr9

35733482

+TMEM8Bchr9

35845972

+
In-frameENST00000353704ENST00000439587CREB3chr9

35733482

+TMEM8Bchr9

35845971

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000353704CREB3chr935733482+ENST00000377996TMEM8Bchr935845972+16528734291610393
ENST00000353704CREB3chr935733482+ENST00000439587TMEM8Bchr935845972+16538734291610393
ENST00000353704CREB3chr935733482+ENST00000377991TMEM8Bchr935845972+30208734292012527
ENST00000353704CREB3chr935733482+ENST00000377996TMEM8Bchr935845971+16528734291610393
ENST00000353704CREB3chr935733482+ENST00000439587TMEM8Bchr935845971+16538734291610393
ENST00000353704CREB3chr935733482+ENST00000377991TMEM8Bchr935845971+30208734292012527

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000353704ENST00000377996CREB3chr935733482+TMEM8Bchr935845972+0.031648050.9683519
ENST00000353704ENST00000439587CREB3chr935733482+TMEM8Bchr935845972+0.0317929420.96820706
ENST00000353704ENST00000377991CREB3chr935733482+TMEM8Bchr935845972+0.0114966340.9885034
ENST00000353704ENST00000377996CREB3chr935733482+TMEM8Bchr935845971+0.031648050.9683519
ENST00000353704ENST00000439587CREB3chr935733482+TMEM8Bchr935845971+0.0317929420.96820706
ENST00000353704ENST00000377991CREB3chr935733482+TMEM8Bchr935845971+0.0114966340.9885034

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Fusion Genomic Features for CREB3-TMEM8B


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
CREB3chr935733482+TMEM8Bchr935845971+0.0006146330.99938536
CREB3chr935733482+TMEM8Bchr935845971+0.0006146330.99938536
CREB3chr935733482+TMEM8Bchr935845971+0.0006146330.99938536
CREB3chr935733482+TMEM8Bchr935845971+0.0006146330.99938536

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for CREB3-TMEM8B


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr9:35733482/chr9:35845972)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCREB3chr9:35733482chr9:35845971ENST00000353704+4913_17145372.0MotifNote=LXXLL motif 1
HgeneCREB3chr9:35733482chr9:35845971ENST00000353704+4954_58145372.0MotifNote=LXXLL motif 2
HgeneCREB3chr9:35733482chr9:35845972ENST00000353704+4913_17145372.0MotifNote=LXXLL motif 1
HgeneCREB3chr9:35733482chr9:35845972ENST00000353704+4954_58145372.0MotifNote=LXXLL motif 2
HgeneCREB3chr9:35733482chr9:35845971ENST00000353704+491_92145372.0RegionTranscription activation (acidic)
HgeneCREB3chr9:35733482chr9:35845972ENST00000353704+491_92145372.0RegionTranscription activation (acidic)
TgeneTMEM8Bchr9:35733482chr9:35845971ENST00000377988513182_22193473.0DomainNote=EGF-like
TgeneTMEM8Bchr9:35733482chr9:35845971ENST00000377991614182_22193473.0DomainNote=EGF-like
TgeneTMEM8Bchr9:35733482chr9:35845971ENST0000037799649182_22193339.0DomainNote=EGF-like
TgeneTMEM8Bchr9:35733482chr9:35845971ENST00000439587611182_22193339.0DomainNote=EGF-like
TgeneTMEM8Bchr9:35733482chr9:35845972ENST00000377988513182_22193473.0DomainNote=EGF-like
TgeneTMEM8Bchr9:35733482chr9:35845972ENST00000377991614182_22193473.0DomainNote=EGF-like
TgeneTMEM8Bchr9:35733482chr9:35845972ENST0000037799649182_22193339.0DomainNote=EGF-like
TgeneTMEM8Bchr9:35733482chr9:35845972ENST00000439587611182_22193339.0DomainNote=EGF-like
TgeneTMEM8Bchr9:35733482chr9:35845971ENST00000377988513255_25793473.0Topological domainCytoplasmic
TgeneTMEM8Bchr9:35733482chr9:35845971ENST00000377988513278_29293473.0Topological domainExtracellular
TgeneTMEM8Bchr9:35733482chr9:35845971ENST00000377988513314_31593473.0Topological domainCytoplasmic
TgeneTMEM8Bchr9:35733482chr9:35845971ENST00000377988513337_34293473.0Topological domainExtracellular
TgeneTMEM8Bchr9:35733482chr9:35845971ENST00000377988513364_37993473.0Topological domainCytoplasmic
TgeneTMEM8Bchr9:35733482chr9:35845971ENST00000377988513401_40593473.0Topological domainExtracellular
TgeneTMEM8Bchr9:35733482chr9:35845971ENST00000377988513427_47293473.0Topological domainCytoplasmic
TgeneTMEM8Bchr9:35733482chr9:35845971ENST00000377991614255_25793473.0Topological domainCytoplasmic
TgeneTMEM8Bchr9:35733482chr9:35845971ENST00000377991614278_29293473.0Topological domainExtracellular
TgeneTMEM8Bchr9:35733482chr9:35845971ENST00000377991614314_31593473.0Topological domainCytoplasmic
TgeneTMEM8Bchr9:35733482chr9:35845971ENST00000377991614337_34293473.0Topological domainExtracellular
TgeneTMEM8Bchr9:35733482chr9:35845971ENST00000377991614364_37993473.0Topological domainCytoplasmic
TgeneTMEM8Bchr9:35733482chr9:35845971ENST00000377991614401_40593473.0Topological domainExtracellular
TgeneTMEM8Bchr9:35733482chr9:35845971ENST00000377991614427_47293473.0Topological domainCytoplasmic
TgeneTMEM8Bchr9:35733482chr9:35845971ENST0000037799649255_25793339.0Topological domainCytoplasmic
TgeneTMEM8Bchr9:35733482chr9:35845971ENST0000037799649278_29293339.0Topological domainExtracellular
TgeneTMEM8Bchr9:35733482chr9:35845971ENST0000037799649314_31593339.0Topological domainCytoplasmic
TgeneTMEM8Bchr9:35733482chr9:35845971ENST0000037799649337_34293339.0Topological domainExtracellular
TgeneTMEM8Bchr9:35733482chr9:35845971ENST0000037799649364_37993339.0Topological domainCytoplasmic
TgeneTMEM8Bchr9:35733482chr9:35845971ENST0000037799649401_40593339.0Topological domainExtracellular
TgeneTMEM8Bchr9:35733482chr9:35845971ENST0000037799649427_47293339.0Topological domainCytoplasmic
TgeneTMEM8Bchr9:35733482chr9:35845971ENST00000439587611255_25793339.0Topological domainCytoplasmic
TgeneTMEM8Bchr9:35733482chr9:35845971ENST00000439587611278_29293339.0Topological domainExtracellular
TgeneTMEM8Bchr9:35733482chr9:35845971ENST00000439587611314_31593339.0Topological domainCytoplasmic
TgeneTMEM8Bchr9:35733482chr9:35845971ENST00000439587611337_34293339.0Topological domainExtracellular
TgeneTMEM8Bchr9:35733482chr9:35845971ENST00000439587611364_37993339.0Topological domainCytoplasmic
TgeneTMEM8Bchr9:35733482chr9:35845971ENST00000439587611401_40593339.0Topological domainExtracellular
TgeneTMEM8Bchr9:35733482chr9:35845971ENST00000439587611427_47293339.0Topological domainCytoplasmic
TgeneTMEM8Bchr9:35733482chr9:35845972ENST00000377988513255_25793473.0Topological domainCytoplasmic
TgeneTMEM8Bchr9:35733482chr9:35845972ENST00000377988513278_29293473.0Topological domainExtracellular
TgeneTMEM8Bchr9:35733482chr9:35845972ENST00000377988513314_31593473.0Topological domainCytoplasmic
TgeneTMEM8Bchr9:35733482chr9:35845972ENST00000377988513337_34293473.0Topological domainExtracellular
TgeneTMEM8Bchr9:35733482chr9:35845972ENST00000377988513364_37993473.0Topological domainCytoplasmic
TgeneTMEM8Bchr9:35733482chr9:35845972ENST00000377988513401_40593473.0Topological domainExtracellular
TgeneTMEM8Bchr9:35733482chr9:35845972ENST00000377988513427_47293473.0Topological domainCytoplasmic
TgeneTMEM8Bchr9:35733482chr9:35845972ENST00000377991614255_25793473.0Topological domainCytoplasmic
TgeneTMEM8Bchr9:35733482chr9:35845972ENST00000377991614278_29293473.0Topological domainExtracellular
TgeneTMEM8Bchr9:35733482chr9:35845972ENST00000377991614314_31593473.0Topological domainCytoplasmic
TgeneTMEM8Bchr9:35733482chr9:35845972ENST00000377991614337_34293473.0Topological domainExtracellular
TgeneTMEM8Bchr9:35733482chr9:35845972ENST00000377991614364_37993473.0Topological domainCytoplasmic
TgeneTMEM8Bchr9:35733482chr9:35845972ENST00000377991614401_40593473.0Topological domainExtracellular
TgeneTMEM8Bchr9:35733482chr9:35845972ENST00000377991614427_47293473.0Topological domainCytoplasmic
TgeneTMEM8Bchr9:35733482chr9:35845972ENST0000037799649255_25793339.0Topological domainCytoplasmic
TgeneTMEM8Bchr9:35733482chr9:35845972ENST0000037799649278_29293339.0Topological domainExtracellular
TgeneTMEM8Bchr9:35733482chr9:35845972ENST0000037799649314_31593339.0Topological domainCytoplasmic
TgeneTMEM8Bchr9:35733482chr9:35845972ENST0000037799649337_34293339.0Topological domainExtracellular
TgeneTMEM8Bchr9:35733482chr9:35845972ENST0000037799649364_37993339.0Topological domainCytoplasmic
TgeneTMEM8Bchr9:35733482chr9:35845972ENST0000037799649401_40593339.0Topological domainExtracellular
TgeneTMEM8Bchr9:35733482chr9:35845972ENST0000037799649427_47293339.0Topological domainCytoplasmic
TgeneTMEM8Bchr9:35733482chr9:35845972ENST00000439587611255_25793339.0Topological domainCytoplasmic
TgeneTMEM8Bchr9:35733482chr9:35845972ENST00000439587611278_29293339.0Topological domainExtracellular
TgeneTMEM8Bchr9:35733482chr9:35845972ENST00000439587611314_31593339.0Topological domainCytoplasmic
TgeneTMEM8Bchr9:35733482chr9:35845972ENST00000439587611337_34293339.0Topological domainExtracellular
TgeneTMEM8Bchr9:35733482chr9:35845972ENST00000439587611364_37993339.0Topological domainCytoplasmic
TgeneTMEM8Bchr9:35733482chr9:35845972ENST00000439587611401_40593339.0Topological domainExtracellular
TgeneTMEM8Bchr9:35733482chr9:35845972ENST00000439587611427_47293339.0Topological domainCytoplasmic
TgeneTMEM8Bchr9:35733482chr9:35845971ENST00000377988513234_25493473.0TransmembraneHelical
TgeneTMEM8Bchr9:35733482chr9:35845971ENST00000377988513258_27793473.0TransmembraneHelical
TgeneTMEM8Bchr9:35733482chr9:35845971ENST00000377988513293_31393473.0TransmembraneHelical
TgeneTMEM8Bchr9:35733482chr9:35845971ENST00000377988513316_33693473.0TransmembraneHelical
TgeneTMEM8Bchr9:35733482chr9:35845971ENST00000377988513343_36393473.0TransmembraneHelical
TgeneTMEM8Bchr9:35733482chr9:35845971ENST00000377988513380_40093473.0TransmembraneHelical
TgeneTMEM8Bchr9:35733482chr9:35845971ENST00000377988513406_42693473.0TransmembraneHelical
TgeneTMEM8Bchr9:35733482chr9:35845971ENST00000377991614234_25493473.0TransmembraneHelical
TgeneTMEM8Bchr9:35733482chr9:35845971ENST00000377991614258_27793473.0TransmembraneHelical
TgeneTMEM8Bchr9:35733482chr9:35845971ENST00000377991614293_31393473.0TransmembraneHelical
TgeneTMEM8Bchr9:35733482chr9:35845971ENST00000377991614316_33693473.0TransmembraneHelical
TgeneTMEM8Bchr9:35733482chr9:35845971ENST00000377991614343_36393473.0TransmembraneHelical
TgeneTMEM8Bchr9:35733482chr9:35845971ENST00000377991614380_40093473.0TransmembraneHelical
TgeneTMEM8Bchr9:35733482chr9:35845971ENST00000377991614406_42693473.0TransmembraneHelical
TgeneTMEM8Bchr9:35733482chr9:35845971ENST0000037799649234_25493339.0TransmembraneHelical
TgeneTMEM8Bchr9:35733482chr9:35845971ENST0000037799649258_27793339.0TransmembraneHelical
TgeneTMEM8Bchr9:35733482chr9:35845971ENST0000037799649293_31393339.0TransmembraneHelical
TgeneTMEM8Bchr9:35733482chr9:35845971ENST0000037799649316_33693339.0TransmembraneHelical
TgeneTMEM8Bchr9:35733482chr9:35845971ENST0000037799649343_36393339.0TransmembraneHelical
TgeneTMEM8Bchr9:35733482chr9:35845971ENST0000037799649380_40093339.0TransmembraneHelical
TgeneTMEM8Bchr9:35733482chr9:35845971ENST0000037799649406_42693339.0TransmembraneHelical
TgeneTMEM8Bchr9:35733482chr9:35845971ENST00000439587611234_25493339.0TransmembraneHelical
TgeneTMEM8Bchr9:35733482chr9:35845971ENST00000439587611258_27793339.0TransmembraneHelical
TgeneTMEM8Bchr9:35733482chr9:35845971ENST00000439587611293_31393339.0TransmembraneHelical
TgeneTMEM8Bchr9:35733482chr9:35845971ENST00000439587611316_33693339.0TransmembraneHelical
TgeneTMEM8Bchr9:35733482chr9:35845971ENST00000439587611343_36393339.0TransmembraneHelical
TgeneTMEM8Bchr9:35733482chr9:35845971ENST00000439587611380_40093339.0TransmembraneHelical
TgeneTMEM8Bchr9:35733482chr9:35845971ENST00000439587611406_42693339.0TransmembraneHelical
TgeneTMEM8Bchr9:35733482chr9:35845972ENST00000377988513234_25493473.0TransmembraneHelical
TgeneTMEM8Bchr9:35733482chr9:35845972ENST00000377988513258_27793473.0TransmembraneHelical
TgeneTMEM8Bchr9:35733482chr9:35845972ENST00000377988513293_31393473.0TransmembraneHelical
TgeneTMEM8Bchr9:35733482chr9:35845972ENST00000377988513316_33693473.0TransmembraneHelical
TgeneTMEM8Bchr9:35733482chr9:35845972ENST00000377988513343_36393473.0TransmembraneHelical
TgeneTMEM8Bchr9:35733482chr9:35845972ENST00000377988513380_40093473.0TransmembraneHelical
TgeneTMEM8Bchr9:35733482chr9:35845972ENST00000377988513406_42693473.0TransmembraneHelical
TgeneTMEM8Bchr9:35733482chr9:35845972ENST00000377991614234_25493473.0TransmembraneHelical
TgeneTMEM8Bchr9:35733482chr9:35845972ENST00000377991614258_27793473.0TransmembraneHelical
TgeneTMEM8Bchr9:35733482chr9:35845972ENST00000377991614293_31393473.0TransmembraneHelical
TgeneTMEM8Bchr9:35733482chr9:35845972ENST00000377991614316_33693473.0TransmembraneHelical
TgeneTMEM8Bchr9:35733482chr9:35845972ENST00000377991614343_36393473.0TransmembraneHelical
TgeneTMEM8Bchr9:35733482chr9:35845972ENST00000377991614380_40093473.0TransmembraneHelical
TgeneTMEM8Bchr9:35733482chr9:35845972ENST00000377991614406_42693473.0TransmembraneHelical
TgeneTMEM8Bchr9:35733482chr9:35845972ENST0000037799649234_25493339.0TransmembraneHelical
TgeneTMEM8Bchr9:35733482chr9:35845972ENST0000037799649258_27793339.0TransmembraneHelical
TgeneTMEM8Bchr9:35733482chr9:35845972ENST0000037799649293_31393339.0TransmembraneHelical
TgeneTMEM8Bchr9:35733482chr9:35845972ENST0000037799649316_33693339.0TransmembraneHelical
TgeneTMEM8Bchr9:35733482chr9:35845972ENST0000037799649343_36393339.0TransmembraneHelical
TgeneTMEM8Bchr9:35733482chr9:35845972ENST0000037799649380_40093339.0TransmembraneHelical
TgeneTMEM8Bchr9:35733482chr9:35845972ENST0000037799649406_42693339.0TransmembraneHelical
TgeneTMEM8Bchr9:35733482chr9:35845972ENST00000439587611234_25493339.0TransmembraneHelical
TgeneTMEM8Bchr9:35733482chr9:35845972ENST00000439587611258_27793339.0TransmembraneHelical
TgeneTMEM8Bchr9:35733482chr9:35845972ENST00000439587611293_31393339.0TransmembraneHelical
TgeneTMEM8Bchr9:35733482chr9:35845972ENST00000439587611316_33693339.0TransmembraneHelical
TgeneTMEM8Bchr9:35733482chr9:35845972ENST00000439587611343_36393339.0TransmembraneHelical
TgeneTMEM8Bchr9:35733482chr9:35845972ENST00000439587611380_40093339.0TransmembraneHelical
TgeneTMEM8Bchr9:35733482chr9:35845972ENST00000439587611406_42693339.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCREB3chr9:35733482chr9:35845971ENST00000353704+49316_361145372.0Compositional biasNote=Pro-rich
HgeneCREB3chr9:35733482chr9:35845972ENST00000353704+49316_361145372.0Compositional biasNote=Pro-rich
HgeneCREB3chr9:35733482chr9:35845971ENST00000353704+49150_213145372.0DomainbZIP
HgeneCREB3chr9:35733482chr9:35845972ENST00000353704+49150_213145372.0DomainbZIP
HgeneCREB3chr9:35733482chr9:35845971ENST00000353704+49152_184145372.0RegionBasic motif
HgeneCREB3chr9:35733482chr9:35845971ENST00000353704+49192_213145372.0RegionLeucine-zipper
HgeneCREB3chr9:35733482chr9:35845972ENST00000353704+49152_184145372.0RegionBasic motif
HgeneCREB3chr9:35733482chr9:35845972ENST00000353704+49192_213145372.0RegionLeucine-zipper
HgeneCREB3chr9:35733482chr9:35845971ENST00000353704+491_230145372.0Topological domainCytoplasmic
HgeneCREB3chr9:35733482chr9:35845971ENST00000353704+49248_371145372.0Topological domainLumenal
HgeneCREB3chr9:35733482chr9:35845972ENST00000353704+491_230145372.0Topological domainCytoplasmic
HgeneCREB3chr9:35733482chr9:35845972ENST00000353704+49248_371145372.0Topological domainLumenal
HgeneCREB3chr9:35733482chr9:35845971ENST00000353704+49231_247145372.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
HgeneCREB3chr9:35733482chr9:35845972ENST00000353704+49231_247145372.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
TgeneTMEM8Bchr9:35733482chr9:35845971ENST000003779885131_23393473.0Topological domainExtracellular
TgeneTMEM8Bchr9:35733482chr9:35845971ENST000003779916141_23393473.0Topological domainExtracellular
TgeneTMEM8Bchr9:35733482chr9:35845971ENST00000377996491_23393339.0Topological domainExtracellular
TgeneTMEM8Bchr9:35733482chr9:35845971ENST000004395876111_23393339.0Topological domainExtracellular
TgeneTMEM8Bchr9:35733482chr9:35845972ENST000003779885131_23393473.0Topological domainExtracellular
TgeneTMEM8Bchr9:35733482chr9:35845972ENST000003779916141_23393473.0Topological domainExtracellular
TgeneTMEM8Bchr9:35733482chr9:35845972ENST00000377996491_23393339.0Topological domainExtracellular
TgeneTMEM8Bchr9:35733482chr9:35845972ENST000004395876111_23393339.0Topological domainExtracellular


Top

Fusion Gene Sequence for CREB3-TMEM8B


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>19341_19341_1_CREB3-TMEM8B_CREB3_chr9_35733482_ENST00000353704_TMEM8B_chr9_35845971_ENST00000377991_length(transcript)=3020nt_BP=873nt
GCGCAATCCGGAGAGGACGCCAGGACGACGCCCGAGTTCCCTTTCAGGCTAGAACTCTTCCTTTTTCTAGCTTGGGGTAGAAGGCGGAGC
CGGAGCCCCGGAACCCCCGCCCTCGGGGTGCGAGGCGGCAGCAGGGCCGTCCCCTACATTTGCATAGCCCCTGGGACGTGGCGCTGCACC
CAAGCCTCTTCTCAGTTGGAGGGAACTCCAAGTCCCACAGTGCCACGGGGTGGGGTGCGTCACTTTCGCTGCGTTGGAGGCTGAGGAGAA
TTGAGCCTGGGAGGCGGGTCCGGAGAGGGCTATGGAAAGCCGCCGGCGGGGAATCCCGGCCGTAGAGGGACAGTGGATAGGTGCCCGAGG
CCTACAGCTGGCCTGGGGCTCGTGTCTGGGCTTCGGACGTTGGGGCCCGGTGGCCCACCCTTTCCGTAGTTGTCCCAAATGGAGCTGGAA
TTGGATGCTGGTGACCAAGACCTGCTGGCCTTCCTGCTAGAGGAAAGTGGAGATTTGGGGACGGCACCCGATGAGGCCGTGAGGGCCCCA
CTGGACTGGGCGCTGCCGCTTTCTGAGGTACCGAGCGACTGGGAAGTAGATGATTTGCTGTGCTCCCTGCTGAGTCCCCCAGCGTCGTTG
AACATTCTCAGCTCCTCCAACCCCTGCCTTGTCCACCATGACCACACCTACTCCCTCCCACGGGAAACTGTCTCTATGGATCTAGAGAGT
GAGAGCTGTAGAAAAGAGGGGACCCAGATGACTCCACAGCATATGGAGGAGCTGGCAGAGCAGGAGATTGCTAGGCTAGTACTGACAGAT
GAGGAGAAGAGTCTATTGGAGAAGGAGGGGCTTATTCTGCCTGAGACACTTCCTCTCACTAAGAGCTCCGTGCGCCAGGAAAACGTGACG
GTGTTTGGATGCTTGACTCACGAGGTGCCCTTGAGCCTGGGGGATGCAGCAGTGACCTGTTCCAAAGAGTCCCTGGCCGGCTTCCTCCTC
TCTGTCAGTGCCACCACCAGGGTTGCCAGGCTGCGAATCCCATTCCCGCAGACGGGGACCTGGTTCCTGGCCCTCCGCTCCCTGTGCGGG
GTGGGGCCTCGGTTCGTGCGGTGCCGCAACGCGACGGCCGAGGTGCGGATGCGCACCTTCCTGTCCCCATGCGTGGACGACTGCGGGCCC
TACGGCCAGTGCAAGCTGCTGCGCACACACAATTATCTGTACGCAGCCTGCGAGTGCAAGGCCGGGTGGAGAGGCTGGGGCTGCACCGAC
AGTGCAGATGCGCTCACCTATGGATTCCAGCTGCTGTCCACACTCCTGCTCTGCCTGAGCAACCTCATGTTTCTGCCACCTGTGGTCCTG
GCCATTCGGAGTCGATATGTGCTGGAAGCTGCAGTCTACACCTTCACCATGTTCTTCTCCACGTTCTATCATGCCTGTGACCAGCCAGGC
ATCGTGGTTTTCTGCATCATGGACTACGATGTGCTGCAGTTCTGTGATTTCCTGGGCTCCTTAATGTCCGTGTGGGTCACTGTCATTGCC
ATGGCTCGTTTACAGCCCGTGGTCAAGCAGGTGCTGTATTTGCTGGGAGCTATGCTGCTGTCCATGGCTCTGCAGCTTGACCGACATGGA
CTCTGGAACCTGCTTGGACCCAGTCTCTTCGCCCTGGGGATCTTGGCCACAGCCTGGACAGTACGCAGCGTCCGCCGCCGGCACTGCTAC
CCACCCACGTGGCGCCGCTGGCTTTTCTACTTGTGCCCTGGCAGCCTTATTGCAGGCAGTGCCGTCCTGCTTTATGCTTTTGTGGAGACC
CGGGACAACTACTTCTACATTCACAGCATTTGGCATATGCTCATTGCGGGCAGTGTGGGCTTCCTGCTGCCCCCTCGTGCCAAGACTGAC
CACGGGGTCCCATCTGGAGCCCGGGCCCGGGGCTGTGGTTACCAGCTATGCATCAACGAGCAGGAGGAGCTGGGCCTCGTGGGCCCAGGA
GGGGCCACTGTCAGCAGCATCTGTGCCAGCTGAGAGGGGCTTTGGGCCTGGCCCTGAGGGGATATGAATGCTTCCTAGAGTTCTTTCTGG
GGGTGTGGAGCCCTCTTAGAAGGAGACAGGCTGTATTTCTTGAGGACATGGAGTCTTTCTCAAGGACACAAAACTCTTCCAGGGACCTGG
AGCCCTTCCCAGGACATGGAGAACTTCCTGAGGGCCTGGAGTCCCCCTGCATCATGGAGTCCTTCTTAAGGACTGGAGCCTATGCAGGCA
CAGAGTCCCTCAGGACCAAGGAGTCCCTCCTGCAGGTGTGGAGCCTTTCCTGGGATGCAGAGCCTTCCCAAGACATGGATTCCTTCCCAG
GGAGACAAAGCCCTGTCAGGAGCACAGCATCTTTCCAGAGGAGGTGGAGTCTATCTTGGGGAAACCAAATTTCCAGATTTTCCCAGAGGC
TCAGCAACTCTGGCCTCAGGCTTCCTTCCCAGAGGCAGCGTCTGGGCTGTGCTGTGCTGTGGAGGAGGGATTGCAGGATGGATGGAGCTG
GGACTGGGGCTGTCTGGGTGGCTGGTATCCTCGTTTGATACAGGTGGAGTCTGTGTGTCTCCAGTGATTGATTGGTTCAGAATGGTTCTG
TGATGCCTTTTTTCCCCCTGGGGTCAGGGGTGTGGGGAAGTGGGGAAAGAGGGCCCCTCAGGGAATCAGCAGGGCTGATGGGAGCTACTG
CCGGAGGCTTTTGTCACACCCTGTACACAGTCTGATCCCGCTCATCTGGGCCCTGCATTCATTTCTAAACAGTTTCTAATGCCTATTCCC
CAATTCCTATTGAGCCCGATTTGCAGTATCTGAGGGGTGTGTGTGTGTGTGTGTGTGTTTATGTATGTATACGTATGCTGAGATGATTTA
AATCAGTGAGACAGACTTTCCTTATGATGCCCACACCCAACACAGAAGGAAGCCGAGGTCCCAGGAAATTGGAATAGCAGGTACACGTCT
CAGGTGTGCAAGAAATATCACAAGAATGTAACTTCTGTTTTGAGCCCCCA

>19341_19341_1_CREB3-TMEM8B_CREB3_chr9_35733482_ENST00000353704_TMEM8B_chr9_35845971_ENST00000377991_length(amino acids)=527AA_BP=1
MSQMELELDAGDQDLLAFLLEESGDLGTAPDEAVRAPLDWALPLSEVPSDWEVDDLLCSLLSPPASLNILSSSNPCLVHHDHTYSLPRET
VSMDLESESCRKEGTQMTPQHMEELAEQEIARLVLTDEEKSLLEKEGLILPETLPLTKSSVRQENVTVFGCLTHEVPLSLGDAAVTCSKE
SLAGFLLSVSATTRVARLRIPFPQTGTWFLALRSLCGVGPRFVRCRNATAEVRMRTFLSPCVDDCGPYGQCKLLRTHNYLYAACECKAGW
RGWGCTDSADALTYGFQLLSTLLLCLSNLMFLPPVVLAIRSRYVLEAAVYTFTMFFSTFYHACDQPGIVVFCIMDYDVLQFCDFLGSLMS
VWVTVIAMARLQPVVKQVLYLLGAMLLSMALQLDRHGLWNLLGPSLFALGILATAWTVRSVRRRHCYPPTWRRWLFYLCPGSLIAGSAVL
LYAFVETRDNYFYIHSIWHMLIAGSVGFLLPPRAKTDHGVPSGARARGCGYQLCINEQEELGLVGPGGATVSSICAS

--------------------------------------------------------------
>19341_19341_2_CREB3-TMEM8B_CREB3_chr9_35733482_ENST00000353704_TMEM8B_chr9_35845971_ENST00000377996_length(transcript)=1652nt_BP=873nt
GCGCAATCCGGAGAGGACGCCAGGACGACGCCCGAGTTCCCTTTCAGGCTAGAACTCTTCCTTTTTCTAGCTTGGGGTAGAAGGCGGAGC
CGGAGCCCCGGAACCCCCGCCCTCGGGGTGCGAGGCGGCAGCAGGGCCGTCCCCTACATTTGCATAGCCCCTGGGACGTGGCGCTGCACC
CAAGCCTCTTCTCAGTTGGAGGGAACTCCAAGTCCCACAGTGCCACGGGGTGGGGTGCGTCACTTTCGCTGCGTTGGAGGCTGAGGAGAA
TTGAGCCTGGGAGGCGGGTCCGGAGAGGGCTATGGAAAGCCGCCGGCGGGGAATCCCGGCCGTAGAGGGACAGTGGATAGGTGCCCGAGG
CCTACAGCTGGCCTGGGGCTCGTGTCTGGGCTTCGGACGTTGGGGCCCGGTGGCCCACCCTTTCCGTAGTTGTCCCAAATGGAGCTGGAA
TTGGATGCTGGTGACCAAGACCTGCTGGCCTTCCTGCTAGAGGAAAGTGGAGATTTGGGGACGGCACCCGATGAGGCCGTGAGGGCCCCA
CTGGACTGGGCGCTGCCGCTTTCTGAGGTACCGAGCGACTGGGAAGTAGATGATTTGCTGTGCTCCCTGCTGAGTCCCCCAGCGTCGTTG
AACATTCTCAGCTCCTCCAACCCCTGCCTTGTCCACCATGACCACACCTACTCCCTCCCACGGGAAACTGTCTCTATGGATCTAGAGAGT
GAGAGCTGTAGAAAAGAGGGGACCCAGATGACTCCACAGCATATGGAGGAGCTGGCAGAGCAGGAGATTGCTAGGCTAGTACTGACAGAT
GAGGAGAAGAGTCTATTGGAGAAGGAGGGGCTTATTCTGCCTGAGACACTTCCTCTCACTAAGAGCTCCGTGCGCCAGGAAAACGTGACG
GTGTTTGGATGCTTGACTCACGAGGTGCCCTTGAGCCTGGGGGATGCAGCAGTGACCTGTTCCAAAGAGTCCCTGGCCGGCTTCCTCCTC
TCTGTCAGTGCCACCACCAGGGTTGCCAGGCTGCGAATCCCATTCCCGCAGACGGGGACCTGGTTCCTGGCCCTCCGCTCCCTGTGCGGG
GTGGGGCCTCGGTTCGTGCGGTGCCGCAACGCGACGGCCGAGGTGCGGATGCGCACCTTCCTGTCCCCATGCGTGGACGACTGCGGGCCC
TACGGCCAGTGCAAGCTGCTGCGCACACACAATTATCTGTACGCAGCCTGCGAGTGCAAGGCCGGGTGGAGAGGCTGGGGCTGCACCGAC
AGTGCAGATGCGCTCACCTATGGATTCCAGCTGCTGTCCACACTCCTGCTCTGCCTGAGCAACCTCATGTTTCTGCCACCTGTGGTCCTG
GCCATTCGGAGTCGATATGTGCTGGAAGCTGCAGTCTACACCTTCACCATGTTCTTCTCCACGGTATGCGGTGGTGTCTGCATCTTATCA
CTGGGTGCTTGTGCATGGTGGTGGGTCACAGTCTGTATTTCCACCACGTTCTCCGAGGGTTTGGGAATGTCTGTGCCTTCACTGTGTCTT
CTACAGACAGAGACAGCAGTGCTTCCCAAACTGTCATGCATAGATAATGGTCATTTTTGTAAGACACATTGGAGTAAATGAACAAAACTG
TTTGCAACTTAATAAAGTAAGTTTGGGCCTCC

>19341_19341_2_CREB3-TMEM8B_CREB3_chr9_35733482_ENST00000353704_TMEM8B_chr9_35845971_ENST00000377996_length(amino acids)=393AA_BP=1
MSQMELELDAGDQDLLAFLLEESGDLGTAPDEAVRAPLDWALPLSEVPSDWEVDDLLCSLLSPPASLNILSSSNPCLVHHDHTYSLPRET
VSMDLESESCRKEGTQMTPQHMEELAEQEIARLVLTDEEKSLLEKEGLILPETLPLTKSSVRQENVTVFGCLTHEVPLSLGDAAVTCSKE
SLAGFLLSVSATTRVARLRIPFPQTGTWFLALRSLCGVGPRFVRCRNATAEVRMRTFLSPCVDDCGPYGQCKLLRTHNYLYAACECKAGW
RGWGCTDSADALTYGFQLLSTLLLCLSNLMFLPPVVLAIRSRYVLEAAVYTFTMFFSTVCGGVCILSLGACAWWWVTVCISTTFSEGLGM
SVPSLCLLQTETAVLPKLSCIDNGHFCKTHWSK

--------------------------------------------------------------
>19341_19341_3_CREB3-TMEM8B_CREB3_chr9_35733482_ENST00000353704_TMEM8B_chr9_35845971_ENST00000439587_length(transcript)=1653nt_BP=873nt
GCGCAATCCGGAGAGGACGCCAGGACGACGCCCGAGTTCCCTTTCAGGCTAGAACTCTTCCTTTTTCTAGCTTGGGGTAGAAGGCGGAGC
CGGAGCCCCGGAACCCCCGCCCTCGGGGTGCGAGGCGGCAGCAGGGCCGTCCCCTACATTTGCATAGCCCCTGGGACGTGGCGCTGCACC
CAAGCCTCTTCTCAGTTGGAGGGAACTCCAAGTCCCACAGTGCCACGGGGTGGGGTGCGTCACTTTCGCTGCGTTGGAGGCTGAGGAGAA
TTGAGCCTGGGAGGCGGGTCCGGAGAGGGCTATGGAAAGCCGCCGGCGGGGAATCCCGGCCGTAGAGGGACAGTGGATAGGTGCCCGAGG
CCTACAGCTGGCCTGGGGCTCGTGTCTGGGCTTCGGACGTTGGGGCCCGGTGGCCCACCCTTTCCGTAGTTGTCCCAAATGGAGCTGGAA
TTGGATGCTGGTGACCAAGACCTGCTGGCCTTCCTGCTAGAGGAAAGTGGAGATTTGGGGACGGCACCCGATGAGGCCGTGAGGGCCCCA
CTGGACTGGGCGCTGCCGCTTTCTGAGGTACCGAGCGACTGGGAAGTAGATGATTTGCTGTGCTCCCTGCTGAGTCCCCCAGCGTCGTTG
AACATTCTCAGCTCCTCCAACCCCTGCCTTGTCCACCATGACCACACCTACTCCCTCCCACGGGAAACTGTCTCTATGGATCTAGAGAGT
GAGAGCTGTAGAAAAGAGGGGACCCAGATGACTCCACAGCATATGGAGGAGCTGGCAGAGCAGGAGATTGCTAGGCTAGTACTGACAGAT
GAGGAGAAGAGTCTATTGGAGAAGGAGGGGCTTATTCTGCCTGAGACACTTCCTCTCACTAAGAGCTCCGTGCGCCAGGAAAACGTGACG
GTGTTTGGATGCTTGACTCACGAGGTGCCCTTGAGCCTGGGGGATGCAGCAGTGACCTGTTCCAAAGAGTCCCTGGCCGGCTTCCTCCTC
TCTGTCAGTGCCACCACCAGGGTTGCCAGGCTGCGAATCCCATTCCCGCAGACGGGGACCTGGTTCCTGGCCCTCCGCTCCCTGTGCGGG
GTGGGGCCTCGGTTCGTGCGGTGCCGCAACGCGACGGCCGAGGTGCGGATGCGCACCTTCCTGTCCCCATGCGTGGACGACTGCGGGCCC
TACGGCCAGTGCAAGCTGCTGCGCACACACAATTATCTGTACGCAGCCTGCGAGTGCAAGGCCGGGTGGAGAGGCTGGGGCTGCACCGAC
AGTGCAGATGCGCTCACCTATGGATTCCAGCTGCTGTCCACACTCCTGCTCTGCCTGAGCAACCTCATGTTTCTGCCACCTGTGGTCCTG
GCCATTCGGAGTCGATATGTGCTGGAAGCTGCAGTCTACACCTTCACCATGTTCTTCTCCACGGTATGCGGTGGTGTCTGCATCTTATCA
CTGGGTGCTTGTGCATGGTGGTGGGTCACAGTCTGTATTTCCACCACGTTCTCCGAGGGTTTGGGAATGTCTGTGCCTTCACTGTGTCTT
CTACAGACAGAGACAGCAGTGCTTCCCAAACTGTCATGCATAGATAATGGTCATTTTTGTAAGACACATTGGAGTAAATGAACAAAACTG
TTTGCAACTTAATAAAGTAAGTTTGGGCCTCCA

>19341_19341_3_CREB3-TMEM8B_CREB3_chr9_35733482_ENST00000353704_TMEM8B_chr9_35845971_ENST00000439587_length(amino acids)=393AA_BP=1
MSQMELELDAGDQDLLAFLLEESGDLGTAPDEAVRAPLDWALPLSEVPSDWEVDDLLCSLLSPPASLNILSSSNPCLVHHDHTYSLPRET
VSMDLESESCRKEGTQMTPQHMEELAEQEIARLVLTDEEKSLLEKEGLILPETLPLTKSSVRQENVTVFGCLTHEVPLSLGDAAVTCSKE
SLAGFLLSVSATTRVARLRIPFPQTGTWFLALRSLCGVGPRFVRCRNATAEVRMRTFLSPCVDDCGPYGQCKLLRTHNYLYAACECKAGW
RGWGCTDSADALTYGFQLLSTLLLCLSNLMFLPPVVLAIRSRYVLEAAVYTFTMFFSTVCGGVCILSLGACAWWWVTVCISTTFSEGLGM
SVPSLCLLQTETAVLPKLSCIDNGHFCKTHWSK

--------------------------------------------------------------
>19341_19341_4_CREB3-TMEM8B_CREB3_chr9_35733482_ENST00000353704_TMEM8B_chr9_35845972_ENST00000377991_length(transcript)=3020nt_BP=873nt
GCGCAATCCGGAGAGGACGCCAGGACGACGCCCGAGTTCCCTTTCAGGCTAGAACTCTTCCTTTTTCTAGCTTGGGGTAGAAGGCGGAGC
CGGAGCCCCGGAACCCCCGCCCTCGGGGTGCGAGGCGGCAGCAGGGCCGTCCCCTACATTTGCATAGCCCCTGGGACGTGGCGCTGCACC
CAAGCCTCTTCTCAGTTGGAGGGAACTCCAAGTCCCACAGTGCCACGGGGTGGGGTGCGTCACTTTCGCTGCGTTGGAGGCTGAGGAGAA
TTGAGCCTGGGAGGCGGGTCCGGAGAGGGCTATGGAAAGCCGCCGGCGGGGAATCCCGGCCGTAGAGGGACAGTGGATAGGTGCCCGAGG
CCTACAGCTGGCCTGGGGCTCGTGTCTGGGCTTCGGACGTTGGGGCCCGGTGGCCCACCCTTTCCGTAGTTGTCCCAAATGGAGCTGGAA
TTGGATGCTGGTGACCAAGACCTGCTGGCCTTCCTGCTAGAGGAAAGTGGAGATTTGGGGACGGCACCCGATGAGGCCGTGAGGGCCCCA
CTGGACTGGGCGCTGCCGCTTTCTGAGGTACCGAGCGACTGGGAAGTAGATGATTTGCTGTGCTCCCTGCTGAGTCCCCCAGCGTCGTTG
AACATTCTCAGCTCCTCCAACCCCTGCCTTGTCCACCATGACCACACCTACTCCCTCCCACGGGAAACTGTCTCTATGGATCTAGAGAGT
GAGAGCTGTAGAAAAGAGGGGACCCAGATGACTCCACAGCATATGGAGGAGCTGGCAGAGCAGGAGATTGCTAGGCTAGTACTGACAGAT
GAGGAGAAGAGTCTATTGGAGAAGGAGGGGCTTATTCTGCCTGAGACACTTCCTCTCACTAAGAGCTCCGTGCGCCAGGAAAACGTGACG
GTGTTTGGATGCTTGACTCACGAGGTGCCCTTGAGCCTGGGGGATGCAGCAGTGACCTGTTCCAAAGAGTCCCTGGCCGGCTTCCTCCTC
TCTGTCAGTGCCACCACCAGGGTTGCCAGGCTGCGAATCCCATTCCCGCAGACGGGGACCTGGTTCCTGGCCCTCCGCTCCCTGTGCGGG
GTGGGGCCTCGGTTCGTGCGGTGCCGCAACGCGACGGCCGAGGTGCGGATGCGCACCTTCCTGTCCCCATGCGTGGACGACTGCGGGCCC
TACGGCCAGTGCAAGCTGCTGCGCACACACAATTATCTGTACGCAGCCTGCGAGTGCAAGGCCGGGTGGAGAGGCTGGGGCTGCACCGAC
AGTGCAGATGCGCTCACCTATGGATTCCAGCTGCTGTCCACACTCCTGCTCTGCCTGAGCAACCTCATGTTTCTGCCACCTGTGGTCCTG
GCCATTCGGAGTCGATATGTGCTGGAAGCTGCAGTCTACACCTTCACCATGTTCTTCTCCACGTTCTATCATGCCTGTGACCAGCCAGGC
ATCGTGGTTTTCTGCATCATGGACTACGATGTGCTGCAGTTCTGTGATTTCCTGGGCTCCTTAATGTCCGTGTGGGTCACTGTCATTGCC
ATGGCTCGTTTACAGCCCGTGGTCAAGCAGGTGCTGTATTTGCTGGGAGCTATGCTGCTGTCCATGGCTCTGCAGCTTGACCGACATGGA
CTCTGGAACCTGCTTGGACCCAGTCTCTTCGCCCTGGGGATCTTGGCCACAGCCTGGACAGTACGCAGCGTCCGCCGCCGGCACTGCTAC
CCACCCACGTGGCGCCGCTGGCTTTTCTACTTGTGCCCTGGCAGCCTTATTGCAGGCAGTGCCGTCCTGCTTTATGCTTTTGTGGAGACC
CGGGACAACTACTTCTACATTCACAGCATTTGGCATATGCTCATTGCGGGCAGTGTGGGCTTCCTGCTGCCCCCTCGTGCCAAGACTGAC
CACGGGGTCCCATCTGGAGCCCGGGCCCGGGGCTGTGGTTACCAGCTATGCATCAACGAGCAGGAGGAGCTGGGCCTCGTGGGCCCAGGA
GGGGCCACTGTCAGCAGCATCTGTGCCAGCTGAGAGGGGCTTTGGGCCTGGCCCTGAGGGGATATGAATGCTTCCTAGAGTTCTTTCTGG
GGGTGTGGAGCCCTCTTAGAAGGAGACAGGCTGTATTTCTTGAGGACATGGAGTCTTTCTCAAGGACACAAAACTCTTCCAGGGACCTGG
AGCCCTTCCCAGGACATGGAGAACTTCCTGAGGGCCTGGAGTCCCCCTGCATCATGGAGTCCTTCTTAAGGACTGGAGCCTATGCAGGCA
CAGAGTCCCTCAGGACCAAGGAGTCCCTCCTGCAGGTGTGGAGCCTTTCCTGGGATGCAGAGCCTTCCCAAGACATGGATTCCTTCCCAG
GGAGACAAAGCCCTGTCAGGAGCACAGCATCTTTCCAGAGGAGGTGGAGTCTATCTTGGGGAAACCAAATTTCCAGATTTTCCCAGAGGC
TCAGCAACTCTGGCCTCAGGCTTCCTTCCCAGAGGCAGCGTCTGGGCTGTGCTGTGCTGTGGAGGAGGGATTGCAGGATGGATGGAGCTG
GGACTGGGGCTGTCTGGGTGGCTGGTATCCTCGTTTGATACAGGTGGAGTCTGTGTGTCTCCAGTGATTGATTGGTTCAGAATGGTTCTG
TGATGCCTTTTTTCCCCCTGGGGTCAGGGGTGTGGGGAAGTGGGGAAAGAGGGCCCCTCAGGGAATCAGCAGGGCTGATGGGAGCTACTG
CCGGAGGCTTTTGTCACACCCTGTACACAGTCTGATCCCGCTCATCTGGGCCCTGCATTCATTTCTAAACAGTTTCTAATGCCTATTCCC
CAATTCCTATTGAGCCCGATTTGCAGTATCTGAGGGGTGTGTGTGTGTGTGTGTGTGTTTATGTATGTATACGTATGCTGAGATGATTTA
AATCAGTGAGACAGACTTTCCTTATGATGCCCACACCCAACACAGAAGGAAGCCGAGGTCCCAGGAAATTGGAATAGCAGGTACACGTCT
CAGGTGTGCAAGAAATATCACAAGAATGTAACTTCTGTTTTGAGCCCCCA

>19341_19341_4_CREB3-TMEM8B_CREB3_chr9_35733482_ENST00000353704_TMEM8B_chr9_35845972_ENST00000377991_length(amino acids)=527AA_BP=1
MSQMELELDAGDQDLLAFLLEESGDLGTAPDEAVRAPLDWALPLSEVPSDWEVDDLLCSLLSPPASLNILSSSNPCLVHHDHTYSLPRET
VSMDLESESCRKEGTQMTPQHMEELAEQEIARLVLTDEEKSLLEKEGLILPETLPLTKSSVRQENVTVFGCLTHEVPLSLGDAAVTCSKE
SLAGFLLSVSATTRVARLRIPFPQTGTWFLALRSLCGVGPRFVRCRNATAEVRMRTFLSPCVDDCGPYGQCKLLRTHNYLYAACECKAGW
RGWGCTDSADALTYGFQLLSTLLLCLSNLMFLPPVVLAIRSRYVLEAAVYTFTMFFSTFYHACDQPGIVVFCIMDYDVLQFCDFLGSLMS
VWVTVIAMARLQPVVKQVLYLLGAMLLSMALQLDRHGLWNLLGPSLFALGILATAWTVRSVRRRHCYPPTWRRWLFYLCPGSLIAGSAVL
LYAFVETRDNYFYIHSIWHMLIAGSVGFLLPPRAKTDHGVPSGARARGCGYQLCINEQEELGLVGPGGATVSSICAS

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>19341_19341_5_CREB3-TMEM8B_CREB3_chr9_35733482_ENST00000353704_TMEM8B_chr9_35845972_ENST00000377996_length(transcript)=1652nt_BP=873nt
GCGCAATCCGGAGAGGACGCCAGGACGACGCCCGAGTTCCCTTTCAGGCTAGAACTCTTCCTTTTTCTAGCTTGGGGTAGAAGGCGGAGC
CGGAGCCCCGGAACCCCCGCCCTCGGGGTGCGAGGCGGCAGCAGGGCCGTCCCCTACATTTGCATAGCCCCTGGGACGTGGCGCTGCACC
CAAGCCTCTTCTCAGTTGGAGGGAACTCCAAGTCCCACAGTGCCACGGGGTGGGGTGCGTCACTTTCGCTGCGTTGGAGGCTGAGGAGAA
TTGAGCCTGGGAGGCGGGTCCGGAGAGGGCTATGGAAAGCCGCCGGCGGGGAATCCCGGCCGTAGAGGGACAGTGGATAGGTGCCCGAGG
CCTACAGCTGGCCTGGGGCTCGTGTCTGGGCTTCGGACGTTGGGGCCCGGTGGCCCACCCTTTCCGTAGTTGTCCCAAATGGAGCTGGAA
TTGGATGCTGGTGACCAAGACCTGCTGGCCTTCCTGCTAGAGGAAAGTGGAGATTTGGGGACGGCACCCGATGAGGCCGTGAGGGCCCCA
CTGGACTGGGCGCTGCCGCTTTCTGAGGTACCGAGCGACTGGGAAGTAGATGATTTGCTGTGCTCCCTGCTGAGTCCCCCAGCGTCGTTG
AACATTCTCAGCTCCTCCAACCCCTGCCTTGTCCACCATGACCACACCTACTCCCTCCCACGGGAAACTGTCTCTATGGATCTAGAGAGT
GAGAGCTGTAGAAAAGAGGGGACCCAGATGACTCCACAGCATATGGAGGAGCTGGCAGAGCAGGAGATTGCTAGGCTAGTACTGACAGAT
GAGGAGAAGAGTCTATTGGAGAAGGAGGGGCTTATTCTGCCTGAGACACTTCCTCTCACTAAGAGCTCCGTGCGCCAGGAAAACGTGACG
GTGTTTGGATGCTTGACTCACGAGGTGCCCTTGAGCCTGGGGGATGCAGCAGTGACCTGTTCCAAAGAGTCCCTGGCCGGCTTCCTCCTC
TCTGTCAGTGCCACCACCAGGGTTGCCAGGCTGCGAATCCCATTCCCGCAGACGGGGACCTGGTTCCTGGCCCTCCGCTCCCTGTGCGGG
GTGGGGCCTCGGTTCGTGCGGTGCCGCAACGCGACGGCCGAGGTGCGGATGCGCACCTTCCTGTCCCCATGCGTGGACGACTGCGGGCCC
TACGGCCAGTGCAAGCTGCTGCGCACACACAATTATCTGTACGCAGCCTGCGAGTGCAAGGCCGGGTGGAGAGGCTGGGGCTGCACCGAC
AGTGCAGATGCGCTCACCTATGGATTCCAGCTGCTGTCCACACTCCTGCTCTGCCTGAGCAACCTCATGTTTCTGCCACCTGTGGTCCTG
GCCATTCGGAGTCGATATGTGCTGGAAGCTGCAGTCTACACCTTCACCATGTTCTTCTCCACGGTATGCGGTGGTGTCTGCATCTTATCA
CTGGGTGCTTGTGCATGGTGGTGGGTCACAGTCTGTATTTCCACCACGTTCTCCGAGGGTTTGGGAATGTCTGTGCCTTCACTGTGTCTT
CTACAGACAGAGACAGCAGTGCTTCCCAAACTGTCATGCATAGATAATGGTCATTTTTGTAAGACACATTGGAGTAAATGAACAAAACTG
TTTGCAACTTAATAAAGTAAGTTTGGGCCTCC

>19341_19341_5_CREB3-TMEM8B_CREB3_chr9_35733482_ENST00000353704_TMEM8B_chr9_35845972_ENST00000377996_length(amino acids)=393AA_BP=1
MSQMELELDAGDQDLLAFLLEESGDLGTAPDEAVRAPLDWALPLSEVPSDWEVDDLLCSLLSPPASLNILSSSNPCLVHHDHTYSLPRET
VSMDLESESCRKEGTQMTPQHMEELAEQEIARLVLTDEEKSLLEKEGLILPETLPLTKSSVRQENVTVFGCLTHEVPLSLGDAAVTCSKE
SLAGFLLSVSATTRVARLRIPFPQTGTWFLALRSLCGVGPRFVRCRNATAEVRMRTFLSPCVDDCGPYGQCKLLRTHNYLYAACECKAGW
RGWGCTDSADALTYGFQLLSTLLLCLSNLMFLPPVVLAIRSRYVLEAAVYTFTMFFSTVCGGVCILSLGACAWWWVTVCISTTFSEGLGM
SVPSLCLLQTETAVLPKLSCIDNGHFCKTHWSK

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>19341_19341_6_CREB3-TMEM8B_CREB3_chr9_35733482_ENST00000353704_TMEM8B_chr9_35845972_ENST00000439587_length(transcript)=1653nt_BP=873nt
GCGCAATCCGGAGAGGACGCCAGGACGACGCCCGAGTTCCCTTTCAGGCTAGAACTCTTCCTTTTTCTAGCTTGGGGTAGAAGGCGGAGC
CGGAGCCCCGGAACCCCCGCCCTCGGGGTGCGAGGCGGCAGCAGGGCCGTCCCCTACATTTGCATAGCCCCTGGGACGTGGCGCTGCACC
CAAGCCTCTTCTCAGTTGGAGGGAACTCCAAGTCCCACAGTGCCACGGGGTGGGGTGCGTCACTTTCGCTGCGTTGGAGGCTGAGGAGAA
TTGAGCCTGGGAGGCGGGTCCGGAGAGGGCTATGGAAAGCCGCCGGCGGGGAATCCCGGCCGTAGAGGGACAGTGGATAGGTGCCCGAGG
CCTACAGCTGGCCTGGGGCTCGTGTCTGGGCTTCGGACGTTGGGGCCCGGTGGCCCACCCTTTCCGTAGTTGTCCCAAATGGAGCTGGAA
TTGGATGCTGGTGACCAAGACCTGCTGGCCTTCCTGCTAGAGGAAAGTGGAGATTTGGGGACGGCACCCGATGAGGCCGTGAGGGCCCCA
CTGGACTGGGCGCTGCCGCTTTCTGAGGTACCGAGCGACTGGGAAGTAGATGATTTGCTGTGCTCCCTGCTGAGTCCCCCAGCGTCGTTG
AACATTCTCAGCTCCTCCAACCCCTGCCTTGTCCACCATGACCACACCTACTCCCTCCCACGGGAAACTGTCTCTATGGATCTAGAGAGT
GAGAGCTGTAGAAAAGAGGGGACCCAGATGACTCCACAGCATATGGAGGAGCTGGCAGAGCAGGAGATTGCTAGGCTAGTACTGACAGAT
GAGGAGAAGAGTCTATTGGAGAAGGAGGGGCTTATTCTGCCTGAGACACTTCCTCTCACTAAGAGCTCCGTGCGCCAGGAAAACGTGACG
GTGTTTGGATGCTTGACTCACGAGGTGCCCTTGAGCCTGGGGGATGCAGCAGTGACCTGTTCCAAAGAGTCCCTGGCCGGCTTCCTCCTC
TCTGTCAGTGCCACCACCAGGGTTGCCAGGCTGCGAATCCCATTCCCGCAGACGGGGACCTGGTTCCTGGCCCTCCGCTCCCTGTGCGGG
GTGGGGCCTCGGTTCGTGCGGTGCCGCAACGCGACGGCCGAGGTGCGGATGCGCACCTTCCTGTCCCCATGCGTGGACGACTGCGGGCCC
TACGGCCAGTGCAAGCTGCTGCGCACACACAATTATCTGTACGCAGCCTGCGAGTGCAAGGCCGGGTGGAGAGGCTGGGGCTGCACCGAC
AGTGCAGATGCGCTCACCTATGGATTCCAGCTGCTGTCCACACTCCTGCTCTGCCTGAGCAACCTCATGTTTCTGCCACCTGTGGTCCTG
GCCATTCGGAGTCGATATGTGCTGGAAGCTGCAGTCTACACCTTCACCATGTTCTTCTCCACGGTATGCGGTGGTGTCTGCATCTTATCA
CTGGGTGCTTGTGCATGGTGGTGGGTCACAGTCTGTATTTCCACCACGTTCTCCGAGGGTTTGGGAATGTCTGTGCCTTCACTGTGTCTT
CTACAGACAGAGACAGCAGTGCTTCCCAAACTGTCATGCATAGATAATGGTCATTTTTGTAAGACACATTGGAGTAAATGAACAAAACTG
TTTGCAACTTAATAAAGTAAGTTTGGGCCTCCA

>19341_19341_6_CREB3-TMEM8B_CREB3_chr9_35733482_ENST00000353704_TMEM8B_chr9_35845972_ENST00000439587_length(amino acids)=393AA_BP=1
MSQMELELDAGDQDLLAFLLEESGDLGTAPDEAVRAPLDWALPLSEVPSDWEVDDLLCSLLSPPASLNILSSSNPCLVHHDHTYSLPRET
VSMDLESESCRKEGTQMTPQHMEELAEQEIARLVLTDEEKSLLEKEGLILPETLPLTKSSVRQENVTVFGCLTHEVPLSLGDAAVTCSKE
SLAGFLLSVSATTRVARLRIPFPQTGTWFLALRSLCGVGPRFVRCRNATAEVRMRTFLSPCVDDCGPYGQCKLLRTHNYLYAACECKAGW
RGWGCTDSADALTYGFQLLSTLLLCLSNLMFLPPVVLAIRSRYVLEAAVYTFTMFFSTVCGGVCILSLGACAWWWVTVCISTTFSEGLGM
SVPSLCLLQTETAVLPKLSCIDNGHFCKTHWSK

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Fusion Gene PPI Analysis for CREB3-TMEM8B


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for CREB3-TMEM8B


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for CREB3-TMEM8B


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource