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in Kim Lab

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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Diseases

Fusion gene:ARFGEF2-TSHZ2 (FusionGDB2 ID:HG10564TG128553)

Fusion Gene Summary for ARFGEF2-TSHZ2

check button Fusion gene summary
Fusion gene informationFusion gene name: ARFGEF2-TSHZ2
Fusion gene ID: hg10564tg128553
HgeneTgene
Gene symbol

ARFGEF2

TSHZ2

Gene ID

10564

128553

Gene nameADP ribosylation factor guanine nucleotide exchange factor 2teashirt zinc finger homeobox 2
SynonymsBIG2|PVNH2|dJ1164I10.1C20orf17|OVC10-2|TSH2|ZABC2|ZNF218
Cytomap('ARFGEF2')('TSHZ2')

20q13.13

20q13.2

Type of geneprotein-codingprotein-coding
Descriptionbrefeldin A-inhibited guanine nucleotide-exchange protein 2ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited)brefeldin A-inhibited GEP 2teashirt homolog 2cell growth-inhibiting protein 7ovarian cancer-related protein 10-2serologically defined colon cancer antigen 33 liketeashirt family zinc finger 2zinc finger protein 218
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000371917, ENST00000493140, 
Fusion gene scores* DoF score15 X 13 X 9=175540 X 23 X 9=8280
# samples 1550
** MAII scorelog2(15/1755*10)=-3.54843662469604
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(50/8280*10)=-4.0496307677246
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ARFGEF2 [Title/Abstract] AND TSHZ2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointARFGEF2(47580435)-TSHZ2(51870038), # samples:3
Anticipated loss of major functional domain due to fusion event.ARFGEF2-TSHZ2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ARFGEF2-TSHZ2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ARFGEF2-TSHZ2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ARFGEF2-TSHZ2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ARFGEF2-TSHZ2 seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
ARFGEF2-TSHZ2 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
ARFGEF2-TSHZ2 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
ARFGEF2-TSHZ2 seems lost the major protein functional domain in Tgene partner, which is a transcription factor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneARFGEF2

GO:0001881

receptor recycling

16477018

HgeneARFGEF2

GO:0035556

intracellular signal transduction

12571360


check buttonFusion gene breakpoints across ARFGEF2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across TSHZ2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-A8-A09D-01AARFGEF2chr20

47580435

-TSHZ2chr20

51870038

+
ChimerDB4BRCATCGA-A8-A09D-01AARFGEF2chr20

47580435

+TSHZ2chr20

51870038

+


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Fusion Gene ORF analysis for ARFGEF2-TSHZ2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000371917ENST00000329613ARFGEF2chr20

47580435

+TSHZ2chr20

51870038

+
In-frameENST00000371917ENST00000371497ARFGEF2chr20

47580435

+TSHZ2chr20

51870038

+
In-frameENST00000371917ENST00000603338ARFGEF2chr20

47580435

+TSHZ2chr20

51870038

+
intron-3CDSENST00000493140ENST00000329613ARFGEF2chr20

47580435

+TSHZ2chr20

51870038

+
intron-3CDSENST00000493140ENST00000371497ARFGEF2chr20

47580435

+TSHZ2chr20

51870038

+
intron-3CDSENST00000493140ENST00000603338ARFGEF2chr20

47580435

+TSHZ2chr20

51870038

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000371917ARFGEF2chr2047580435+ENST00000371497TSHZ2chr2051870038+12167907039711323
ENST00000371917ARFGEF2chr2047580435+ENST00000603338TSHZ2chr2051870038+4316907039711323

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000371917ENST00000371497ARFGEF2chr2047580435+TSHZ2chr2051870038+0.0001508150.9998492
ENST00000371917ENST00000603338ARFGEF2chr2047580435+TSHZ2chr2051870038+0.0016656010.99833447

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Fusion Genomic Features for ARFGEF2-TSHZ2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
ARFGEF2chr2047580435+TSHZ2chr2051870037+1.80E-131
ARFGEF2chr2047580435+TSHZ2chr2051870037+1.80E-131

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for ARFGEF2-TSHZ2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr20:47580435/chr20:51870038)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneTSHZ2chr20:47580435chr20:51870038ENST000003296130213_38101032.0Coiled coilOntology_term=ECO:0000255
TgeneTSHZ2chr20:47580435chr20:51870038ENST000003714970313_38133455.0Coiled coilOntology_term=ECO:0000255
TgeneTSHZ2chr20:47580435chr20:51870038ENST000006033380313_38101012.6666666666666Coiled coilOntology_term=ECO:0000255
TgeneTSHZ2chr20:47580435chr20:51870038ENST0000032961302841_911101032.0DNA bindingNote=Homeobox%3B atypical
TgeneTSHZ2chr20:47580435chr20:51870038ENST0000037149703841_911133455.0DNA bindingNote=Homeobox%3B atypical
TgeneTSHZ2chr20:47580435chr20:51870038ENST0000060333803841_911101012.6666666666666DNA bindingNote=Homeobox%3B atypical
TgeneTSHZ2chr20:47580435chr20:51870038ENST0000032961302215_239101032.0Zinc fingerC2H2-type 1
TgeneTSHZ2chr20:47580435chr20:51870038ENST0000032961302275_299101032.0Zinc fingerC2H2-type 2
TgeneTSHZ2chr20:47580435chr20:51870038ENST0000032961302380_404101032.0Zinc fingerC2H2-type 3%3B atypical
TgeneTSHZ2chr20:47580435chr20:51870038ENST0000032961302926_948101032.0Zinc fingerC2H2-type 4
TgeneTSHZ2chr20:47580435chr20:51870038ENST0000032961302994_1017101032.0Zinc fingerC2H2-type 5
TgeneTSHZ2chr20:47580435chr20:51870038ENST0000037149703215_239133455.0Zinc fingerC2H2-type 1
TgeneTSHZ2chr20:47580435chr20:51870038ENST0000037149703275_299133455.0Zinc fingerC2H2-type 2
TgeneTSHZ2chr20:47580435chr20:51870038ENST0000037149703380_404133455.0Zinc fingerC2H2-type 3%3B atypical
TgeneTSHZ2chr20:47580435chr20:51870038ENST0000037149703926_948133455.0Zinc fingerC2H2-type 4
TgeneTSHZ2chr20:47580435chr20:51870038ENST0000037149703994_1017133455.0Zinc fingerC2H2-type 5
TgeneTSHZ2chr20:47580435chr20:51870038ENST0000060333803215_239101012.6666666666666Zinc fingerC2H2-type 1
TgeneTSHZ2chr20:47580435chr20:51870038ENST0000060333803275_299101012.6666666666666Zinc fingerC2H2-type 2
TgeneTSHZ2chr20:47580435chr20:51870038ENST0000060333803380_404101012.6666666666666Zinc fingerC2H2-type 3%3B atypical
TgeneTSHZ2chr20:47580435chr20:51870038ENST0000060333803926_948101012.6666666666666Zinc fingerC2H2-type 4
TgeneTSHZ2chr20:47580435chr20:51870038ENST0000060333803994_1017101012.6666666666666Zinc fingerC2H2-type 5

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneARFGEF2chr20:47580435chr20:51870038ENST00000371917+739654_7853021786.0DomainSEC7


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Fusion Gene Sequence for ARFGEF2-TSHZ2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>5878_5878_1_ARFGEF2-TSHZ2_ARFGEF2_chr20_47580435_ENST00000371917_TSHZ2_chr20_51870038_ENST00000371497_length(transcript)=12167nt_BP=907nt
ATGCAGGAGAGCCAGACCAAGAGCATGTTCGTGTCCCGGGCCCTGGAGAAGATCCTAGCCGACAAGGAGGTGAAGCGGCCCCAGCACTCC
CAGCTGCGCAGGGCCTGCCAGGTGGCGCTCGATGAAATTAAAGCAGAAATAGAAAAGCAGAGGCTTGGCACTGCTGCACCACCAAAGGCA
AACTTCATTGAAGCTGACAAGTATTTTCTTCCATTCGAGCTAGCTTGCCAGTCCAAGTCCCCAAGGGTAGTCAGCACATCCCTTGACTGC
TTGCAGAAACTCATCGCATACGGGCACATCACTGGCAACGCCCCTGACAGTGGAGCCCCTGGGAAGCGGCTGATCGACAGAATTGTTGAA
ACCATTTGCAGTTGTTTTCAGGGCCCTCAGACTGATGAAGGGGTTCAGTTACAAATAATTAAGGCTCTTCTGACTGCAGTGACTTCCCCA
CACATTGAAATTCATGAGGGTACTATCCTGCAGACAGTGAGAACATGTTACAATATCTATTTGGCCAGCAAAAATCTCATCAATCAAACC
ACTGCCAAGGCTACCCTTACTCAGATGCTGAACGTCATTTTCACCCGCATGGAAAACCAAGTGTTGCAGGAGGCCAGAGAACTGGAAAAA
CCAATCCAGTCAAAACCCCAGTCCCCTGTGATCCAAGCTGCAGCAGTATCCCCAAAGTTCGTTCGTTTGAAGCACAGTCAGGCACAAAGC
AAACCAACAACTCCCGAAAAAACAGATTTAACCAACGGTGAACATGCCAGGAGTGATTCTGGAAAAGTAAGCACAGAAAATGGAGACGCA
CCCAGAGAAAGAGGCTCATCACTGTCAGGGACTGATGACGGAGCCCAGGAGGTGGTGAAGGACATCTTGGAAGATGTAGTCACATCTGCC
ATTAAAGGCTACGCCCAGGAGGAACAGCTGAAAGAAGAGGAGGAAATAAAAGAAGAGGAGGAGGAGGAGGACAGCGGTTCAGTAGCTCAA
CTGCAGGGTGGCAATGACACAGGGACGGACGAGGAGCTAGAAACGGGCCCAGAGCAAAAAGGCTGCTTCAGCTACCAGAACTCTCCAGGA
AGTCATTTGTCCAATCAGGATGCCGAGAACGAGTCTCTGCTGAGTGACGCCAGTGATCAGGTGTCGGACATCAAGAGTGTCTGCGGCAGA
GATGCCTCAGACAAGAAAGCACACACTCACGTCAGGCTTCCAAACGAAGCACACAATTGCATGGATAAAATGACCGCTGTCTACGCCAAC
ATCCTGTCGGATTCCTACTGGTCAGGCCTGGGCCTTGGCTTCAAGCTGTCCAATAGTGAGAGGAGGAACTGTGACACCCGAAACGGCAGC
AACAAGAGTGATTTTGATTGGCACCAAGACGCTCTGTCCAAAAGCCTGCAGCAGAACTTGCCTTCTCGGTCCGTCTCGAAACCCAGCCTG
TTCAGCTCGGTGCAGTTGTACCGACAGAGCAGCAAGATGTGCGGGACTGTGTTCACAGGGGCCAGCAGATTCCGATGCCGACAGTGCAGC
GCGGCCTATGACACCCTAGTCGAGCTGACTGTGCACATGAATGAAACGGGCCACTATCAAGATGACAACCGCAAAAAGGACAAGCTCAGA
CCCACGAGCTATTCAAAGCCCAGGAAAAGGGCTTTCCAGGATATGGACAAAGAGGATGCTCAAAAGGTTCTGAAATGTATGTTTTGTGGC
GACTCCTTTGATTCCCTCCAAGATTTGAGCGTCCACATGATTAAAACAAAACATTACCAAAAAGTGCCTTTGAAGGAGCCAGTCCCAACC
ATTTCCTCGAAAATGGTCACCCCGGCTAAGAAACGCGTTTTTGATGTCAATCGGCCGTGTTCCCCCGATTCAACCACAGGATCTTTTGCA
GATTCTTTTTCTTCTCAGAAGAACGCCAACTTGCAGTTGTCCTCCAACAACCGCTATGGCTACCAAAATGGAGCCAGCTACACCTGGCAG
TTTGAGGCCTGCAAGTCCCAGATCTTAAAGTGCATGGAGTGTGGGAGCTCCCATGACACCTTGCAGCAGCTCACCACCCACATGATGGTC
ACAGGTCACTTTCTCAAGGTCACCAGCTCTGCCTCCAAGAAAGGGAAGCAGCTGGTATTAGACCCGTTAGCAGTGGAGAAAATGCAGTCG
TTGTCTGAGGCCCCAAACAGTGATTCTCTGGCTCCCAAGCCATCCAGTAACTCAGCATCAGATTGTACAGCCTCTACAACTGAGTTAAAG
AAAGAGAGTAAAAAAGAAAGGCCAGAGGAAACCAGCAAGGATGAGAAAGTCGTGAAAAGCGAGGACTATGAAGATCCTCTACAAAAACCT
TTAGACCCTACAATCAAATATCAATACCTAAGGGAGGAAGACTTGGAAGATGGCTCAAAGGGTGGAGGGGACATTTTGAAATCTTTGGAA
AATACTGTCACCACAGCCATCAACAAAGCCCAAAACGGGGCCCCCAGCTGGAGTGCCTACCCCAGCATCCACGCAGCCTACCAGCTGTCT
GAGGGCACCAAGCCGCCTTTGCCTATGGGATCCCAGGTACTGCAGATCCGGCCTAATCTCACCAACAAGCTGAGGCCCATTGCACCAAAG
TGGAAAGTGATGCCACTGGTTTCTATGCCCACACACCTGGCCCCTTACACTCAAGTCAAGAAAGAGTCAGAAGACAAAGATGAAGCGGTG
AAGGAGTGTGGGAAAGAAAGTCCCCACGAAGAGGCCTCATCTTTCAGCCACAGTGAGGGCGATTCTTTCCGCAAAAGTGAAACACCTCCA
GAAGCCAAAAAGACCGAGCTGGGTCCCCTGAAGGAGGAGGAGAAGCTGATGAAAGAGGGCAGCGAGAAGGAGAAACCCCAGCCCCTGGAG
CCCACATCTGCTCTGAGCAATGGGTGCGCCCTCGCCAACCACGCCCCGGCCCTGCCATGCATCAACCCACTCAGCGCCCTGCAGTCCGTC
CTGAACAATCACTTGGGCAAAGCCACGGAGCCCTTGCGCTCACCTTCCTGCTCCAGCCCAAGTTCAAGCACAATTTCCATGTTCCACAAG
TCGAATCTCAATGTCATGGACAAGCCGGTCTTGAGTCCTGCCTCCACAAGGTCAGCCAGCGTGTCCAGGCGCTACCTGTTTGAGAACAGC
GATCAGCCCATTGACCTGACCAAGTCCAAAAGCAAGAAAGCCGAGTCCTCGCAAGCACAATCTTGTATGTCCCCACCTCAGAAGCACGCT
CTGTCTGACATCGCCGACATGGTCAAAGTCCTCCCCAAAGCCACCACCCCAAAGCCAGCCTCCTCCTCCAGGGTCCCCCCCATGAAGCTG
GAAATGGATGTCAGGCGCTTTGAGGATGTCTCCAGTGAAGTCTCAACTTTGCATAAAAGAAAAGGCCGGCAGTCCAACTGGAATCCTCAG
CATCTTCTGATTCTACAAGCCCAGTTTGCCTCGAGCCTCTTCCAGACATCAGAGGGCAAATACCTGCTGTCTGATCTGGGCCCACAAGAG
CGTATGCAAATCTCTAAGTTTACGGGACTCTCAATGACCACTATCAGTCACTGGCTGGCCAACGTCAAGTACCAGCTTAGGAAAACGGGC
GGGACAAAATTTCTGAAAAACATGGACAAAGGCCACCCCATCTTTTATTGCAGTGACTGTGCCTCCCAGTTCAGAACCCCTTCTACCTAC
ATCAGTCACTTAGAATCTCACCTGGGTTTCCAAATGAAGGACATGACCCGCTTGTCAGTGGACCAGCAAAGCAAGGTGGAGCAAGAGATC
TCCCGGGTATCGTCGGCTCAGAGGTCTCCAGAAACAATAGCTGCCGAAGAGGACACAGACTCTAAATTCAAGTGTAAGTTGTGCTGTCGG
ACATTTGTGAGCAAACATGCGGTAAAACTCCACCTAAGCAAAACGCACAGCAAGTCACCCGAACACCATTCACAGTTTGTAACAGACGTG
GATGAAGAATAGCTCTGCAGGACGAATGCCTTAGTTTCCACTTTCCAGCCTGGATCCCCTCACACTGAACCCTTCTTCGTTGCACCATCC
TGCTTCTGACATTGAACTCATTGAACTCCTCCTGACACCCTGGCTCTGAGAAGACTGCCAAAAAAAAAAAAAAAAAAAAATCACCCCAGC
CATTTCTCTTCATCCTCACTAACAATTTGGTAATGAAGTATTGATTTCCACTTCTCTGCTTATGGGCGGTATTAGATTTTCATTGATAAA
TTGCAATGGGGCTGTCTCGTCTCCACAGTACCCTTTTCACTGTCACAAGAAAACAAAGTGCCACCGAAGAAAAGTAATGACTGAGAGCAT
TGATGTACTTATTTTGTCAGTTTGTAACAGGAAAGTGGGGGGGAGTCTAAGTCTTCATAGTCTAATGTCCAAGTGGGTTGCACTAGATGT
AGACACTTGGAGGCTTACTTTTCATGGTAATGTCCATTTCCTATTTATAACCCCTCTGGGAACGTTTGTCTAAAGGAAATGTTTCTGTTC
AGTGTAACAATTACAGTTGCACCTGGATTGCCCAGTCCTGCCCCTGCACTAGGGGACCATTAATCACTGCAAAGTAGAAGAATTATTAAG
TTAAACCAGAGTTTGAGCCAAGAAAACCCCTGAACAATGTTCATCTTCTGTGAAACTTGCTCAAATAGTTAAGCTTAACCATGTTGCTGC
CAAAGACTTTTCCTATGCAGTGGTGGGGCACCTTGATCATCATCATTATCTTGATTGGCTGAAAAAAAAATAGTTTTAAGCACACACCAC
TGTCTATGAGAACTGCAAATTGGGAGAATAGGTGAAATGCAGAATCTGAGAGAACGCGAGAAGATGAGATCATTACAGGGTGGAAAGTTC
TGCAGCAGCCTTTTCTGGTAATCCCTTTCTGCAGAACCTGATGTTTATGGGCTCTAAAACGCAGCTTAGCTTTAGAAGCAACAGAAAGCA
TGAAATAGGGTGTCCATTTTAAATGTGTTCCTGCAACTTTTTTCATTAAAACTTTGAGGGCCCAATTTTAATTTGTGGAATATTCCCGTT
AATAATGAGATCTAATTAAGACATCCATTAAAAGCCCGTTAAAGTTAATTTAACGTAAAAATTCCAATAGAACTGTATTAGATTTTCTCC
ATTAAATTAACGTTATGGATTTTTAACGGATGTCTTAATTATACGTTATTATTAACGGGAATACTGTATTACACAGATTAAAATCAGGTC
CTAAGTCAACTTGGAAGAGCTAAGAGCATGTTTTAATATTAAAAGTCTTGCATACCTAGTGCACAGTTTGGAGACGCAAGGATAGATCTG
TTTACTCTAGTTGAACATTTTCTATACAATTGAAAGCAACCTATAATAGATAAATCCATCATTGCATTTAAACAATGAATTTCCTTATTC
TCAAAGGACAAATACGTCTGGATTATGTGGTAAATTGCTACTCAGCTATGGTGAAATATTTATACTATTCTAGGCACAACACTAGGAACT
AGGTGATTCTGAAACAAAAGGAATATTTTCTGTTGTTGCTTTAATTACCAAGGTTATTTTTTTTTAATCTCAACACTGACAAAATGAAAC
CAAATATCTCTTCCTCACCATTTCTCAAGGAGGCTGCCTGTTGGAATTGTTTTGGAAATTTTGACATGATCCCTAAATTCAACATTGGGA
TTAAAAAAAAAAAAAAACTTCTTATTTACCTCCTAGGGAAAGTGTTGCCCTTATGCCACATATAATAGCAAATTGCTTTTTTTATGGCAT
GCATAACCTAGATGGGAAAAAATATGGCGCTTCGGGGAAGGAGGGAAAAAGTAAATGAAGTTCCAGGAATGTCATTCTGAAGTAATGAGG
CATGGACAGAAAATATACCCCTCACATCATCGGATTGAGATGGCAGTCGAAATAGCTTCATTGAAGTGTCAGCACTCATCCATCAATCAA
TCACCCACAAGGAAAAATAGCAACAGTACAACGGGGTGGCTTTTATGGGATTTACTCATGGGCATAGGGAATAGCGGCTCAAATGTAGTT
CTGACATGAAAAGCAAGGTGCTGATATTATTTTTTATGATGGGAGGATCATAAAGTGAATTGAGAACAGTGAGGTCTGTCTTTGCTTAAC
CTATTCAACCAGAAATGAATGGAGCTCGACTGGAAAGGAACAGTCTTCAGATGGGTTAAGATTGAAGGGTGGACTGGACTCTACTGAGCA
CCGTCCTTCAACAAGGAAATTCTATTAAAGGAAAATCAATGCATTAGTATTGGGGTTCTCGTAGCTGTTAAAAATTGTCTGCTCCAATCC
AGGGTTATTAGGCCAAAGTTACATAATTCAGATCTCACTGCAACCATCCAAAAGTGGATTCTCGAGCCCTTGCTCCAATGGGGGGAGGAG
ATCAATACAATTCCCAATTCCATGGAAATTGTTTCCCTTCTAAGGAAGAAAAAATAAATCATCTGCTTCAACATATAATCGATATGGTTT
TGTTAGCGTAATTTCTATGGTGGGTGGGGTGGGAGGTGAGAGAAAAAAATATTGATAAATTTGGTAAGACAGGTGAATTGCCGCCTGGCA
ACCGTGCATGTCACTGCCGAGGGATGGCTGCTAAGGTTCACCTTAGAAAACAAGATCTGGGCTGGCACTGGGGCATACATCACCACTCAG
CATATTCCTAGAGGCCAGGCCTGTCTTCACTCAGCCAGCCCTCTGAGGCTTCTAGAAACTTCTTTCTGGAGGAAAAAAACTAAATAACAT
AAACTCAGGAGAATGTCTTTACCCACCTTCATACCACTGCTTTCTTTTTGCTGAATAAAACACAGTTCTGATAAGTAAGAACTTTAGAAT
TGGAAAGGAGGCTGACATGCAAATATAATGCAAATTACCCTCAAGTATCGCCATTCTTCCACCACCTCTTGGTACCAGTGAGAGCGAGAG
ATTGCCTTTTCTTCCCCATCCCTCCTTCCAGCTAAGACCACCAACCAGCTGCAAATTGAGATGTCCATTTAAAAATTTATATGTCAATAT
TTAAATGTTACATATTTGGCCCTATTTTGTAGTTCAGCAAATCCTCCAAATACACAGCATGTTACAAGGCACTGGTGGCACAGGGCACAA
CAGGAAATGATATTTATTTAGCAAATTCATTTAACAAATATTATTGGGCACCTGTTATGTGAGACACTGTCCTAGGCACTGTGGGATAAC
AACAGCAAACACTTCACACAACAGCCTGGCCTTCCTGTGTTTTACAACAGCTCCTAAAGATAGCTGATATCAAGACATTTGAGGGACACA
GTTCATGTAGAATCAAAATATTAGTATTTCAGAATAAGGATTTTTTTTCTGAAAAGCATACAGAGAGGAAACAGCTTAAAAATAGGTCAA
GACCTAAAAACAGAATATAATCACGGAATAAACTGGATAACCCAGACAGTCCCCACAGAATTTCTTTCAGGTCACAGATTTCTTAAAACT
CACCCCCAAAATGTGCCTGCTTGGTTGTTTGAATCTTGCATAATTAATGTCACAGGCGCAAGCCGCTGAACTTAGTTGAGATGCAGAAAA
CAAACAAATGCAATGACATATCTGAGAAGCATTTATGTAACTCCGGTTAAGTGGTGAGGAGGGGTGTGTGAAGACAGTGTGCATGCATGA
GTGTGTATTCATATATATGTGTATACATATGAATTTCACTGTTATTTTCCAGGGTCTATGGACAATGTGGCAGTAAGAGTCTATGATGTT
CTGAAACTTTTCACAGTAAATCCAAAGATTACAGACCTTACAAGGTGCTTGCATTCTGTTGCTTTTCCATCTGTCACTTCTCAGGTTATT
TGACTGTGTTCAAACCTTCTTTTCTTTTTCATTGAGTTTCATTTTTTAAGCTTGTTAAATGCTTTTGTTTAAAAAAAAAAAAAAAACCCC
AAATGTCATTTTTCACATTATCCTCTCTTCTCTGCAACAAGGATAGTAAGATGTAGATGAATGCAAAAATAATAACAACAATAAGGAAAT
ATATTAAAGCTTTAAAATATGCACATATGTAGTTCTAAAGAGCAATAACGGTAGTATCTATTTCGAACATGCATTAGGCAAAAAAGAAAT
CAAAACTGAAATTTTCGTGTATTTTTCCCCTTGTAAGATGTTCAAATGCTAACTTCATTTTCTCCTTTCCTCTATGTGGCACTTTCTCAA
AATATCTATGAAATACTTTTAGACAAAGATTGAGCTGGAGAAAGAGATACAAATTTCCATCCCCCCAGACAGAGAGACATATTTCCATTG
TAGGAAGGCATTAAACATTTTGAAACTTGTGAATCATCTTTAGAATTTCTACTGGGGAATTTTACTTCTTCATCCAAAGTAAAAGCCACT
TATCTCCTTTGGTTCCCAGTGACAGATTCAGAGGCATACGCAGATATACAATTTTCAGGCTCTAGTTAATCTTCTTCCAATAGTTACGAA
CAATGGGCTAACAGGCGTGGGTGTTTCTCCAAAAATTATTCATGCACAAGGCAGCCCAAAGCTTCAGGGAAAACTAGAAATGTGTTATGG
ATTAGAATAGGACTGTTTTAAAATGCTAGTACCAGGTGGAACGCTATTTCTGCAACAGGACTCTGTCCATTTCCTTTGGAACAATATATT
CCAAGTAAAATGGCTCTTCCAAGGAATGACACCTTTACTTGACACCCTTCGGCATACAAATGATTTTACCAATAGCCATGATTATTATTA
AGGCCTTTTAAAATACAGGCTGTTTGAAAAAAGACAGATTAAATATTCACAGCCTTTGTATCATGGTTATTTGCTTAAAACAGCTTTTAG
AAGTACAAGTAATAACTTTTTGATAAGAAACCCCAGGAGAAACTTTTTGGTAAGAAACCTCAAAAAATTTGAACAAAGGCATTACAAAAA
AAAAAAAAAAACTAACCACTCCATTCAACTCTCTCAGAAAATAAATTTCAATGTGTTCAATGAATTGTCTTGAACCTGAAACCTGCATTT
AGATATCAGTCCCCTGCCAATAGCTAATATTAACAGAATTTGAACAATCATACAATTATGTCTCAAATGTGAAGACTTTGTACAGTAATA
TTTTCACTTTCTAAATGACCCATATAACATTCAGGAATTATAGATGTGTATGTATATTTTTTAAGTACAGAAAGTTCAGCCAGTCTTCAG
AGAAGTAAAAGTGATGTCTATTGTGCATTGAAGTAAATATTACAAACATTCCAGTTTCGCAATACAATACTTGAGCTTTCGAACACCTCA
GACACTAGAATGTGTAATGCGAGTCAAAAAAGCTGACATACAAAACAATTCCCATTTGGCTCAGGGTTCCTAAATGTCACAATATCTTGG
GTAAAATATACTTTTTGATTTCCTGATGATGTCCTTCTAATCCCTTCTGACTTTGATTCCTAACAGCCAGGCACTGTTGACATGAATCAT
TAACTTCCAAACCCCTTTAAAATCAAGAAGCTAGGTGATCATACAGTCATTTCAATGGCCAACCAGTTCTTGCTCTACAGAGCTTTTACA
CCTTTTTGGGAAACCTGATATCAAACACATTTATGTTATATATTTGCTCCCTTGCATTAATTCTAGATTTTTTTTTAATTTCTTTTAGAA
AGGGCAGGGGGGAAGTGGGTCAGAGCAAGGTTCAAGAATCACATTCATCCTTGCTCTAAAGTGTTTACTTGCCAGCAAAGAAAGGCAAAC
ACATTTTTATATTCAGAAAGCAGACCGGTCATTTTCAAAGAAAAATGACTGCAACCATGCCTGTAGAATGTTTCTGTGCAAGCGCACTAA
TTTTCTATCACCTGCATGCTGTATATAATACATTTGCCTGTATACTAGGAAGAAAAACCAGGCTGTTTTCCCTGAGTACAATGCAGCTTG
GATGGCTGGGAGCGTAAGCCTTCCGTGCATTTTTATAGTGTACATATTTGTATATACTAACTATATCGCCATGTATGAACACAGATTTTG
TTATATTTGCTTGTTTCTGTTTCCTACCAAACTGGCCCACAATGGGGATTCTTTTGTATAGAAAAAATATGCTTGTAATTTTTTCCTGGT
CATTCTCTTTCAATAGCTTATGAAAGAATTAGATCTGAGTTTACAAAGAAACTATAAGAACCAAGTTTGTCTGTCTGCATGAGTCCCGTC
CAATTGCTGGATCTAGGGAGGAACCAACTTCCTAATTCAGAGTTTTCCTTTTAAAGGCATGCTTTACCCCCATGGGAAAACTGCACACTC
ATCCATGTAGAATTATTCTCTTTGTATTTTATCTAATAGTGCCTGAAAATTTTTTTAATGTCTTCTTAGAAGAAGAATTCATAATTGTCA
AAATTTGAAACATTAGCTTAATTTTGTTTTTATGACCTCAAGATTCTTCTCCTTATTTATTCGGTTGCTGTTGTAATGGGGCCCCAGGCC
ATTCCTGACATCGGCGTGTTCTTCTTCTGCATTAAGGATGTTTTTGAAATTACAGAGATTATTGAGCCAACAGGCTGTTTTAATCAAAAC
CATGTTTCACTTCTTTTTGATGATTATAAATTGTCCTTGCAATGAAAAAAAAAAAAGAACTTTTCTGCTAGGAAGATTATACCACCCTGT
GGCCAAACAGATTCATCACAGATAGGCATCTATGCCCATTTCTCTGGGATCTGGAAAATTCTTCCCTTGGCTGACCCCAATTTCTTTTAC
TCCCCATTATCCTGAATATTAGCTTTCAATGCAGTCACTATTTGACATTTCCAAAGGCTTTGCCGCATTGTCACTGCCCAAAGACAAACA
ACCACTGGAAATGATGGCTTTCCTGCTTGAAACGAAGGGGGCCAGGTGCAGTGGCTCAAGCCTGTAACCCCTGCACTTTGGAAGGCTGAG
GCAGGCGGATCACTTGAGGTCAGGAGTTTCAGACCAACCTGGCCAACATGGCAAAACCTCGTCTCTACTAAAAATACAAAAAACATTAGC
AGGGCATGGTGGTGCGTGCCTGTAGTCCCAGCTACTTGGGAGGCTGAGGCAAGAGAATTGCTTGAGCCCGGGAGGCGAAGGTTGCAGTGA
GCTGAGATGGTGCCACTGCACTCCAGCCTGGGCAACAGAGCAAGACTGTGTCTCAAAAAAAAAAAAAAGAATGGATTTTCAGAAAAAGTG
CTCCCTTTCCTGTCCTGTGGTGCCACCATCCTGTCCTCCTTCGTAATCATGAACAATCTGATCTTGAACTCCCACATAACTTAAATCAGG
CAAAAAGAAACATTCACAGCGTCCCCTTGCTGAATAAAAATGACTTTGTTTGGAGGCACTTAAGATGTATGCCTGTGTGTGGTGCCGCAG
CATTGAAATTATCTGTAGAAGGGGAATTTTTTTTAAAAATACAATTTTATCACTAGAAATAAATTCCGATGGTGGAAACGAAGAAAACCC
TTAAATTATATCACAAAAGCCATTATTTTTTGCATCCAAAGAGTTTTTTTTTTTAAGGAAAATCATTCTACTTTGAGAACTGTAATTAAA
GCCCTAAATAACAGACACTACTTTGTTGAGCTATTGTGAAAAAAAAACAACACATTCGCCAAGGTTATATGGAGCCCCTGATTTCCATCA
AAAAGGTTTCTATAAGTATATTATTTACATTTTTATACATGATAACTCTTGCCTTTGTGTTGAAAAAAAAAAAGTCTCTTTTTTTTCCCC
CACTCAGCAGTTATTGGAAATAGACTGTTCCCATCTGAAACCGTATCGTAATTTGCATCAGGAAACCCAACTGCTGACATTGAGGACCTG
GGTGTGTTCAATTATGATTTTGCTGGAGGCTGTCCCTCATTTTAATGCTGCAGCTATTGAACCACCTTCCTGAAACCTAGCTGATACGGA
ATAGCAGAGACATGCCTCTCAACACCATTAGCTTTGCAAATGGCTTCATTTCAGTCAACGTCGACTTCTGCTTTGGCCAATTGAAAAATG
AAAATTAAAGGAGAGAAGAAAAAAAACACAGATGCACTTAAAACATGAAAAGAATTATTTATATGATAAAAATATATTTAGCTTTTCAAA
GCACAAGACTGAATAGAAGTGCTCTTTTTATGCTTTCTGGAGATGTTACTGTTAAATGTCTTTCTACATCAGGCTTAATAAATCTGTAAT
GACATTTGATGGATTGA

>5878_5878_1_ARFGEF2-TSHZ2_ARFGEF2_chr20_47580435_ENST00000371917_TSHZ2_chr20_51870038_ENST00000371497_length(amino acids)=1323AA_BP=302
MQESQTKSMFVSRALEKILADKEVKRPQHSQLRRACQVALDEIKAEIEKQRLGTAAPPKANFIEADKYFLPFELACQSKSPRVVSTSLDC
LQKLIAYGHITGNAPDSGAPGKRLIDRIVETICSCFQGPQTDEGVQLQIIKALLTAVTSPHIEIHEGTILQTVRTCYNIYLASKNLINQT
TAKATLTQMLNVIFTRMENQVLQEARELEKPIQSKPQSPVIQAAAVSPKFVRLKHSQAQSKPTTPEKTDLTNGEHARSDSGKVSTENGDA
PRERGSSLSGTDDGAQEVVKDILEDVVTSAIKGYAQEEQLKEEEEIKEEEEEEDSGSVAQLQGGNDTGTDEELETGPEQKGCFSYQNSPG
SHLSNQDAENESLLSDASDQVSDIKSVCGRDASDKKAHTHVRLPNEAHNCMDKMTAVYANILSDSYWSGLGLGFKLSNSERRNCDTRNGS
NKSDFDWHQDALSKSLQQNLPSRSVSKPSLFSSVQLYRQSSKMCGTVFTGASRFRCRQCSAAYDTLVELTVHMNETGHYQDDNRKKDKLR
PTSYSKPRKRAFQDMDKEDAQKVLKCMFCGDSFDSLQDLSVHMIKTKHYQKVPLKEPVPTISSKMVTPAKKRVFDVNRPCSPDSTTGSFA
DSFSSQKNANLQLSSNNRYGYQNGASYTWQFEACKSQILKCMECGSSHDTLQQLTTHMMVTGHFLKVTSSASKKGKQLVLDPLAVEKMQS
LSEAPNSDSLAPKPSSNSASDCTASTTELKKESKKERPEETSKDEKVVKSEDYEDPLQKPLDPTIKYQYLREEDLEDGSKGGGDILKSLE
NTVTTAINKAQNGAPSWSAYPSIHAAYQLSEGTKPPLPMGSQVLQIRPNLTNKLRPIAPKWKVMPLVSMPTHLAPYTQVKKESEDKDEAV
KECGKESPHEEASSFSHSEGDSFRKSETPPEAKKTELGPLKEEEKLMKEGSEKEKPQPLEPTSALSNGCALANHAPALPCINPLSALQSV
LNNHLGKATEPLRSPSCSSPSSSTISMFHKSNLNVMDKPVLSPASTRSASVSRRYLFENSDQPIDLTKSKSKKAESSQAQSCMSPPQKHA
LSDIADMVKVLPKATTPKPASSSRVPPMKLEMDVRRFEDVSSEVSTLHKRKGRQSNWNPQHLLILQAQFASSLFQTSEGKYLLSDLGPQE
RMQISKFTGLSMTTISHWLANVKYQLRKTGGTKFLKNMDKGHPIFYCSDCASQFRTPSTYISHLESHLGFQMKDMTRLSVDQQSKVEQEI
SRVSSAQRSPETIAAEEDTDSKFKCKLCCRTFVSKHAVKLHLSKTHSKSPEHHSQFVTDVDEE

--------------------------------------------------------------
>5878_5878_2_ARFGEF2-TSHZ2_ARFGEF2_chr20_47580435_ENST00000371917_TSHZ2_chr20_51870038_ENST00000603338_length(transcript)=4316nt_BP=907nt
ATGCAGGAGAGCCAGACCAAGAGCATGTTCGTGTCCCGGGCCCTGGAGAAGATCCTAGCCGACAAGGAGGTGAAGCGGCCCCAGCACTCC
CAGCTGCGCAGGGCCTGCCAGGTGGCGCTCGATGAAATTAAAGCAGAAATAGAAAAGCAGAGGCTTGGCACTGCTGCACCACCAAAGGCA
AACTTCATTGAAGCTGACAAGTATTTTCTTCCATTCGAGCTAGCTTGCCAGTCCAAGTCCCCAAGGGTAGTCAGCACATCCCTTGACTGC
TTGCAGAAACTCATCGCATACGGGCACATCACTGGCAACGCCCCTGACAGTGGAGCCCCTGGGAAGCGGCTGATCGACAGAATTGTTGAA
ACCATTTGCAGTTGTTTTCAGGGCCCTCAGACTGATGAAGGGGTTCAGTTACAAATAATTAAGGCTCTTCTGACTGCAGTGACTTCCCCA
CACATTGAAATTCATGAGGGTACTATCCTGCAGACAGTGAGAACATGTTACAATATCTATTTGGCCAGCAAAAATCTCATCAATCAAACC
ACTGCCAAGGCTACCCTTACTCAGATGCTGAACGTCATTTTCACCCGCATGGAAAACCAAGTGTTGCAGGAGGCCAGAGAACTGGAAAAA
CCAATCCAGTCAAAACCCCAGTCCCCTGTGATCCAAGCTGCAGCAGTATCCCCAAAGTTCGTTCGTTTGAAGCACAGTCAGGCACAAAGC
AAACCAACAACTCCCGAAAAAACAGATTTAACCAACGGTGAACATGCCAGGAGTGATTCTGGAAAAGTAAGCACAGAAAATGGAGACGCA
CCCAGAGAAAGAGGCTCATCACTGTCAGGGACTGATGACGGAGCCCAGGAGGTGGTGAAGGACATCTTGGAAGATGTAGTCACATCTGCC
ATTAAAGGCTACGCCCAGGAGGAACAGCTGAAAGAAGAGGAGGAAATAAAAGAAGAGGAGGAGGAGGAGGACAGCGGTTCAGTAGCTCAA
CTGCAGGGTGGCAATGACACAGGGACGGACGAGGAGCTAGAAACGGGCCCAGAGCAAAAAGGCTGCTTCAGCTACCAGAACTCTCCAGGA
AGTCATTTGTCCAATCAGGATGCCGAGAACGAGTCTCTGCTGAGTGACGCCAGTGATCAGGTGTCGGACATCAAGAGTGTCTGCGGCAGA
GATGCCTCAGACAAGAAAGCACACACTCACGTCAGGCTTCCAAACGAAGCACACAATTGCATGGATAAAATGACCGCTGTCTACGCCAAC
ATCCTGTCGGATTCCTACTGGTCAGGCCTGGGCCTTGGCTTCAAGCTGTCCAATAGTGAGAGGAGGAACTGTGACACCCGAAACGGCAGC
AACAAGAGTGATTTTGATTGGCACCAAGACGCTCTGTCCAAAAGCCTGCAGCAGAACTTGCCTTCTCGGTCCGTCTCGAAACCCAGCCTG
TTCAGCTCGGTGCAGTTGTACCGACAGAGCAGCAAGATGTGCGGGACTGTGTTCACAGGGGCCAGCAGATTCCGATGCCGACAGTGCAGC
GCGGCCTATGACACCCTAGTCGAGCTGACTGTGCACATGAATGAAACGGGCCACTATCAAGATGACAACCGCAAAAAGGACAAGCTCAGA
CCCACGAGCTATTCAAAGCCCAGGAAAAGGGCTTTCCAGGATATGGACAAAGAGGATGCTCAAAAGGTTCTGAAATGTATGTTTTGTGGC
GACTCCTTTGATTCCCTCCAAGATTTGAGCGTCCACATGATTAAAACAAAACATTACCAAAAAGTGCCTTTGAAGGAGCCAGTCCCAACC
ATTTCCTCGAAAATGGTCACCCCGGCTAAGAAACGCGTTTTTGATGTCAATCGGCCGTGTTCCCCCGATTCAACCACAGGATCTTTTGCA
GATTCTTTTTCTTCTCAGAAGAACGCCAACTTGCAGTTGTCCTCCAACAACCGCTATGGCTACCAAAATGGAGCCAGCTACACCTGGCAG
TTTGAGGCCTGCAAGTCCCAGATCTTAAAGTGCATGGAGTGTGGGAGCTCCCATGACACCTTGCAGCAGCTCACCACCCACATGATGGTC
ACAGGTCACTTTCTCAAGGTCACCAGCTCTGCCTCCAAGAAAGGGAAGCAGCTGGTATTAGACCCGTTAGCAGTGGAGAAAATGCAGTCG
TTGTCTGAGGCCCCAAACAGTGATTCTCTGGCTCCCAAGCCATCCAGTAACTCAGCATCAGATTGTACAGCCTCTACAACTGAGTTAAAG
AAAGAGAGTAAAAAAGAAAGGCCAGAGGAAACCAGCAAGGATGAGAAAGTCGTGAAAAGCGAGGACTATGAAGATCCTCTACAAAAACCT
TTAGACCCTACAATCAAATATCAATACCTAAGGGAGGAAGACTTGGAAGATGGCTCAAAGGGTGGAGGGGACATTTTGAAATCTTTGGAA
AATACTGTCACCACAGCCATCAACAAAGCCCAAAACGGGGCCCCCAGCTGGAGTGCCTACCCCAGCATCCACGCAGCCTACCAGCTGTCT
GAGGGCACCAAGCCGCCTTTGCCTATGGGATCCCAGGTACTGCAGATCCGGCCTAATCTCACCAACAAGCTGAGGCCCATTGCACCAAAG
TGGAAAGTGATGCCACTGGTTTCTATGCCCACACACCTGGCCCCTTACACTCAAGTCAAGAAAGAGTCAGAAGACAAAGATGAAGCGGTG
AAGGAGTGTGGGAAAGAAAGTCCCCACGAAGAGGCCTCATCTTTCAGCCACAGTGAGGGCGATTCTTTCCGCAAAAGTGAAACACCTCCA
GAAGCCAAAAAGACCGAGCTGGGTCCCCTGAAGGAGGAGGAGAAGCTGATGAAAGAGGGCAGCGAGAAGGAGAAACCCCAGCCCCTGGAG
CCCACATCTGCTCTGAGCAATGGGTGCGCCCTCGCCAACCACGCCCCGGCCCTGCCATGCATCAACCCACTCAGCGCCCTGCAGTCCGTC
CTGAACAATCACTTGGGCAAAGCCACGGAGCCCTTGCGCTCACCTTCCTGCTCCAGCCCAAGTTCAAGCACAATTTCCATGTTCCACAAG
TCGAATCTCAATGTCATGGACAAGCCGGTCTTGAGTCCTGCCTCCACAAGGTCAGCCAGCGTGTCCAGGCGCTACCTGTTTGAGAACAGC
GATCAGCCCATTGACCTGACCAAGTCCAAAAGCAAGAAAGCCGAGTCCTCGCAAGCACAATCTTGTATGTCCCCACCTCAGAAGCACGCT
CTGTCTGACATCGCCGACATGGTCAAAGTCCTCCCCAAAGCCACCACCCCAAAGCCAGCCTCCTCCTCCAGGGTCCCCCCCATGAAGCTG
GAAATGGATGTCAGGCGCTTTGAGGATGTCTCCAGTGAAGTCTCAACTTTGCATAAAAGAAAAGGCCGGCAGTCCAACTGGAATCCTCAG
CATCTTCTGATTCTACAAGCCCAGTTTGCCTCGAGCCTCTTCCAGACATCAGAGGGCAAATACCTGCTGTCTGATCTGGGCCCACAAGAG
CGTATGCAAATCTCTAAGTTTACGGGACTCTCAATGACCACTATCAGTCACTGGCTGGCCAACGTCAAGTACCAGCTTAGGAAAACGGGC
GGGACAAAATTTCTGAAAAACATGGACAAAGGCCACCCCATCTTTTATTGCAGTGACTGTGCCTCCCAGTTCAGAACCCCTTCTACCTAC
ATCAGTCACTTAGAATCTCACCTGGGTTTCCAAATGAAGGACATGACCCGCTTGTCAGTGGACCAGCAAAGCAAGGTGGAGCAAGAGATC
TCCCGGGTATCGTCGGCTCAGAGGTCTCCAGAAACAATAGCTGCCGAAGAGGACACAGACTCTAAATTCAAGTGTAAGTTGTGCTGTCGG
ACATTTGTGAGCAAACATGCGGTAAAACTCCACCTAAGCAAAACGCACAGCAAGTCACCCGAACACCATTCACAGTTTGTAACAGACGTG
GATGAAGAATAGCTCTGCAGGACGAATGCCTTAGTTTCCACTTTCCAGCCTGGATCCCCTCACACTGAACCCTTCTTCGTTGCACCATCC
TGCTTCTGACATTGAACTCATTGAACTCCTCCTGACACCCTGGCTCTGAGAAGACTGCCAAAAAAAAAAAAAAAAAAAAATCACCCCAGC
CATTTCTCTTCATCCTCACTAACAATTTGGTAATGAAGTATTGATTTCCACTTCTCTGCTTATGGGCGGTATTAGATTTTCATTGATAAA
TTGCAATGGGGCTGTCTCGTCTCCACAGTACCCTTTTCACTGTCACAAGAAAACAAAGTGCCACCGAAGAAAAGTAATGACTGAGA

>5878_5878_2_ARFGEF2-TSHZ2_ARFGEF2_chr20_47580435_ENST00000371917_TSHZ2_chr20_51870038_ENST00000603338_length(amino acids)=1323AA_BP=302
MQESQTKSMFVSRALEKILADKEVKRPQHSQLRRACQVALDEIKAEIEKQRLGTAAPPKANFIEADKYFLPFELACQSKSPRVVSTSLDC
LQKLIAYGHITGNAPDSGAPGKRLIDRIVETICSCFQGPQTDEGVQLQIIKALLTAVTSPHIEIHEGTILQTVRTCYNIYLASKNLINQT
TAKATLTQMLNVIFTRMENQVLQEARELEKPIQSKPQSPVIQAAAVSPKFVRLKHSQAQSKPTTPEKTDLTNGEHARSDSGKVSTENGDA
PRERGSSLSGTDDGAQEVVKDILEDVVTSAIKGYAQEEQLKEEEEIKEEEEEEDSGSVAQLQGGNDTGTDEELETGPEQKGCFSYQNSPG
SHLSNQDAENESLLSDASDQVSDIKSVCGRDASDKKAHTHVRLPNEAHNCMDKMTAVYANILSDSYWSGLGLGFKLSNSERRNCDTRNGS
NKSDFDWHQDALSKSLQQNLPSRSVSKPSLFSSVQLYRQSSKMCGTVFTGASRFRCRQCSAAYDTLVELTVHMNETGHYQDDNRKKDKLR
PTSYSKPRKRAFQDMDKEDAQKVLKCMFCGDSFDSLQDLSVHMIKTKHYQKVPLKEPVPTISSKMVTPAKKRVFDVNRPCSPDSTTGSFA
DSFSSQKNANLQLSSNNRYGYQNGASYTWQFEACKSQILKCMECGSSHDTLQQLTTHMMVTGHFLKVTSSASKKGKQLVLDPLAVEKMQS
LSEAPNSDSLAPKPSSNSASDCTASTTELKKESKKERPEETSKDEKVVKSEDYEDPLQKPLDPTIKYQYLREEDLEDGSKGGGDILKSLE
NTVTTAINKAQNGAPSWSAYPSIHAAYQLSEGTKPPLPMGSQVLQIRPNLTNKLRPIAPKWKVMPLVSMPTHLAPYTQVKKESEDKDEAV
KECGKESPHEEASSFSHSEGDSFRKSETPPEAKKTELGPLKEEEKLMKEGSEKEKPQPLEPTSALSNGCALANHAPALPCINPLSALQSV
LNNHLGKATEPLRSPSCSSPSSSTISMFHKSNLNVMDKPVLSPASTRSASVSRRYLFENSDQPIDLTKSKSKKAESSQAQSCMSPPQKHA
LSDIADMVKVLPKATTPKPASSSRVPPMKLEMDVRRFEDVSSEVSTLHKRKGRQSNWNPQHLLILQAQFASSLFQTSEGKYLLSDLGPQE
RMQISKFTGLSMTTISHWLANVKYQLRKTGGTKFLKNMDKGHPIFYCSDCASQFRTPSTYISHLESHLGFQMKDMTRLSVDQQSKVEQEI
SRVSSAQRSPETIAAEEDTDSKFKCKLCCRTFVSKHAVKLHLSKTHSKSPEHHSQFVTDVDEE

--------------------------------------------------------------

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Fusion Gene PPI Analysis for ARFGEF2-TSHZ2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ARFGEF2-TSHZ2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ARFGEF2-TSHZ2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneARFGEF2C1842563Heterotopia, Periventricular, Autosomal Recessive3CTD_human;GENOMICS_ENGLAND;UNIPROT
HgeneARFGEF2C1868720Periventricular Nodular Heterotopia2GENOMICS_ENGLAND;ORPHANET