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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ARFGEF2-HNF4A (FusionGDB2 ID:HG10564TG3172)

Fusion Gene Summary for ARFGEF2-HNF4A

check button Fusion gene summary
Fusion gene informationFusion gene name: ARFGEF2-HNF4A
Fusion gene ID: hg10564tg3172
HgeneTgene
Gene symbol

ARFGEF2

HNF4A

Gene ID

10564

3172

Gene nameADP ribosylation factor guanine nucleotide exchange factor 2hepatocyte nuclear factor 4 alpha
SynonymsBIG2|PVNH2|dJ1164I10.1FRTS4|HNF4|HNF4a7|HNF4a8|HNF4a9|HNF4alpha|MODY|MODY1|NR2A1|NR2A21|TCF|TCF14
Cytomap('ARFGEF2')('HNF4A')

20q13.13

20q13.12

Type of geneprotein-codingprotein-coding
Descriptionbrefeldin A-inhibited guanine nucleotide-exchange protein 2ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited)brefeldin A-inhibited GEP 2hepatocyte nuclear factor 4-alphaHNF4alpha10/11/12TCF-14hepatic nuclear factor 4 alphanuclear receptor subfamily 2 group A member 1transcription factor 14transcription factor HNF-4
Modification date2020031320200329
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000371917, ENST00000493140, 
Fusion gene scores* DoF score15 X 13 X 9=17556 X 6 X 5=180
# samples 157
** MAII scorelog2(15/1755*10)=-3.54843662469604
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(7/180*10)=-1.36257007938471
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ARFGEF2 [Title/Abstract] AND HNF4A [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointARFGEF2(47538547)-HNF4A(43034698), # samples:2
Anticipated loss of major functional domain due to fusion event.ARFGEF2-HNF4A seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ARFGEF2-HNF4A seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ARFGEF2-HNF4A seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ARFGEF2-HNF4A seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneARFGEF2

GO:0001881

receptor recycling

16477018

HgeneARFGEF2

GO:0035556

intracellular signal transduction

12571360

TgeneHNF4A

GO:0006357

regulation of transcription by RNA polymerase II

10330009|12911579

TgeneHNF4A

GO:0007596

blood coagulation

12911579

TgeneHNF4A

GO:0019216

regulation of lipid metabolic process

10551874

TgeneHNF4A

GO:0045892

negative regulation of transcription, DNA-templated

30530698

TgeneHNF4A

GO:0045893

positive regulation of transcription, DNA-templated

16488887

TgeneHNF4A

GO:0045944

positive regulation of transcription by RNA polymerase II

7615825


check buttonFusion gene breakpoints across ARFGEF2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across HNF4A (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SARCTCGA-DX-A1KX-01AARFGEF2chr20

47538547

-HNF4Achr20

43034698

+
ChimerDB4SARCTCGA-DX-A1KX-01AARFGEF2chr20

47538547

+HNF4Achr20

43034698

+


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Fusion Gene ORF analysis for ARFGEF2-HNF4A

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000371917ENST00000316099ARFGEF2chr20

47538547

+HNF4Achr20

43034698

+
In-frameENST00000371917ENST00000316673ARFGEF2chr20

47538547

+HNF4Achr20

43034698

+
In-frameENST00000371917ENST00000415691ARFGEF2chr20

47538547

+HNF4Achr20

43034698

+
In-frameENST00000371917ENST00000443598ARFGEF2chr20

47538547

+HNF4Achr20

43034698

+
In-frameENST00000371917ENST00000457232ARFGEF2chr20

47538547

+HNF4Achr20

43034698

+
In-frameENST00000371917ENST00000609795ARFGEF2chr20

47538547

+HNF4Achr20

43034698

+
intron-3CDSENST00000493140ENST00000316099ARFGEF2chr20

47538547

+HNF4Achr20

43034698

+
intron-3CDSENST00000493140ENST00000316673ARFGEF2chr20

47538547

+HNF4Achr20

43034698

+
intron-3CDSENST00000493140ENST00000415691ARFGEF2chr20

47538547

+HNF4Achr20

43034698

+
intron-3CDSENST00000493140ENST00000443598ARFGEF2chr20

47538547

+HNF4Achr20

43034698

+
intron-3CDSENST00000493140ENST00000457232ARFGEF2chr20

47538547

+HNF4Achr20

43034698

+
intron-3CDSENST00000493140ENST00000609795ARFGEF2chr20

47538547

+HNF4Achr20

43034698

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000371917ARFGEF2chr2047538547+ENST00000316673HNF4Achr2043034698+143712101430476
ENST00000371917ARFGEF2chr2047538547+ENST00000609795HNF4Achr2043034698+126012101259419
ENST00000371917ARFGEF2chr2047538547+ENST00000457232HNF4Achr2043034698+140712101400466
ENST00000371917ARFGEF2chr2047538547+ENST00000443598HNF4Achr2043034698+152012101259419
ENST00000371917ARFGEF2chr2047538547+ENST00000316099HNF4Achr2043034698+461112101430476
ENST00000371917ARFGEF2chr2047538547+ENST00000415691HNF4Achr2043034698+223612101400466

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000371917ENST00000316673ARFGEF2chr2047538547+HNF4Achr2043034698+0.0083631980.9916368
ENST00000371917ENST00000609795ARFGEF2chr2047538547+HNF4Achr2043034698+0.0131954870.9868045
ENST00000371917ENST00000457232ARFGEF2chr2047538547+HNF4Achr2043034698+0.0049841470.9950159
ENST00000371917ENST00000443598ARFGEF2chr2047538547+HNF4Achr2043034698+0.0104758940.98952407
ENST00000371917ENST00000316099ARFGEF2chr2047538547+HNF4Achr2043034698+0.0093497710.9906502
ENST00000371917ENST00000415691ARFGEF2chr2047538547+HNF4Achr2043034698+0.010237850.9897621

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Fusion Genomic Features for ARFGEF2-HNF4A


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
ARFGEF2chr2047538547+HNF4Achr2043034697+3.15E-081
ARFGEF2chr2047538547+HNF4Achr2043034697+3.15E-081

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for ARFGEF2-HNF4A


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr20:47538547/chr20:43034698)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneHNF4Achr20:47538547chr20:43034698ENST0000031609901057_13238475.0DNA bindingNuclear receptor
TgeneHNF4Achr20:47538547chr20:43034698ENST0000031667301057_13216453.0DNA bindingNuclear receptor
TgeneHNF4Achr20:47538547chr20:43034698ENST0000041569101057_13238465.0DNA bindingNuclear receptor
TgeneHNF4Achr20:47538547chr20:43034698ENST000004435980857_13238418.0DNA bindingNuclear receptor
TgeneHNF4Achr20:47538547chr20:43034698ENST0000045723201057_13216443.0DNA bindingNuclear receptor
TgeneHNF4Achr20:47538547chr20:43034698ENST00000316099010147_37738475.0DomainNR LBD
TgeneHNF4Achr20:47538547chr20:43034698ENST00000316673010147_37716453.0DomainNR LBD
TgeneHNF4Achr20:47538547chr20:43034698ENST00000415691010147_37738465.0DomainNR LBD
TgeneHNF4Achr20:47538547chr20:43034698ENST0000044359808147_37738418.0DomainNR LBD
TgeneHNF4Achr20:47538547chr20:43034698ENST00000457232010147_37716443.0DomainNR LBD
TgeneHNF4Achr20:47538547chr20:43034698ENST00000316099010368_37638475.0Motif9aaTAD
TgeneHNF4Achr20:47538547chr20:43034698ENST00000316673010368_37616453.0Motif9aaTAD
TgeneHNF4Achr20:47538547chr20:43034698ENST00000415691010368_37638465.0Motif9aaTAD
TgeneHNF4Achr20:47538547chr20:43034698ENST0000044359808368_37638418.0Motif9aaTAD
TgeneHNF4Achr20:47538547chr20:43034698ENST00000457232010368_37616443.0Motif9aaTAD
TgeneHNF4Achr20:47538547chr20:43034698ENST0000031609901060_8038475.0Zinc fingerNR C4-type
TgeneHNF4Achr20:47538547chr20:43034698ENST0000031609901096_12038475.0Zinc fingerNR C4-type
TgeneHNF4Achr20:47538547chr20:43034698ENST0000031667301060_8016453.0Zinc fingerNR C4-type
TgeneHNF4Achr20:47538547chr20:43034698ENST0000031667301096_12016453.0Zinc fingerNR C4-type
TgeneHNF4Achr20:47538547chr20:43034698ENST0000041569101060_8038465.0Zinc fingerNR C4-type
TgeneHNF4Achr20:47538547chr20:43034698ENST0000041569101096_12038465.0Zinc fingerNR C4-type
TgeneHNF4Achr20:47538547chr20:43034698ENST000004435980860_8038418.0Zinc fingerNR C4-type
TgeneHNF4Achr20:47538547chr20:43034698ENST000004435980896_12038418.0Zinc fingerNR C4-type
TgeneHNF4Achr20:47538547chr20:43034698ENST0000045723201060_8016443.0Zinc fingerNR C4-type
TgeneHNF4Achr20:47538547chr20:43034698ENST0000045723201096_12016443.0Zinc fingerNR C4-type

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneARFGEF2chr20:47538547chr20:43034698ENST00000371917+139654_785401786.0DomainSEC7


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Fusion Gene Sequence for ARFGEF2-HNF4A


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>5869_5869_1_ARFGEF2-HNF4A_ARFGEF2_chr20_47538547_ENST00000371917_HNF4A_chr20_43034698_ENST00000316099_length(transcript)=4611nt_BP=121nt
ATGCAGGAGAGCCAGACCAAGAGCATGTTCGTGTCCCGGGCCCTGGAGAAGATCCTAGCCGACAAGGAGGTGAAGCGGCCCCAGCACTCC
CAGCTGCGCAGGGCCTGCCAGGTGGCGCTCGACACGTCCCCATCAGAAGGCACCAACCTCAACGCGCCCAACAGCCTGGGTGTCAGCGCC
CTGTGTGCCATCTGCGGGGACCGGGCCACGGGCAAACACTACGGTGCCTCGAGCTGTGACGGCTGCAAGGGCTTCTTCCGGAGGAGCGTG
CGGAAGAACCACATGTACTCCTGCAGATTTAGCCGGCAGTGCGTGGTGGACAAAGACAAGAGGAACCAGTGCCGCTACTGCAGGCTCAAG
AAATGCTTCCGGGCTGGCATGAAGAAGGAAGCCGTCCAGAATGAGCGGGACCGGATCAGCACTCGAAGGTCAAGCTATGAGGACAGCAGC
CTGCCCTCCATCAATGCGCTCCTGCAGGCGGAGGTCCTGTCCCGACAGATCACCTCCCCCGTCTCCGGGATCAACGGCGACATTCGGGCG
AAGAAGATTGCCAGCATCGCAGATGTGTGTGAGTCCATGAAGGAGCAGCTGCTGGTTCTCGTTGAGTGGGCCAAGTACATCCCAGCTTTC
TGCGAGCTCCCCCTGGACGACCAGGTGGCCCTGCTCAGAGCCCATGCTGGCGAGCACCTGCTGCTCGGAGCCACCAAGAGATCCATGGTG
TTCAAGGACGTGCTGCTCCTAGGCAATGACTACATTGTCCCTCGGCACTGCCCGGAGCTGGCGGAGATGAGCCGGGTGTCCATACGCATC
CTTGACGAGCTGGTGCTGCCCTTCCAGGAGCTGCAGATCGATGACAATGAGTATGCCTACCTCAAAGCCATCATCTTCTTTGACCCAGAT
GCCAAGGGGCTGAGCGATCCAGGGAAGATCAAGCGGCTGCGTTCCCAGGTGCAGGTGAGCTTGGAGGACTACATCAACGACCGCCAGTAT
GACTCGCGTGGCCGCTTTGGAGAGCTGCTGCTGCTGCTGCCCACCTTGCAGAGCATCACCTGGCAGATGATCGAGCAGATCCAGTTCATC
AAGCTCTTCGGCATGGCCAAGATTGACAACCTGTTGCAGGAGATGCTGCTGGGAGGGTCCCCCAGCGATGCACCCCATGCCCACCACCCC
CTGCACCCTCACCTGATGCAGGAACATATGGGAACCAACGTCATCGTTGCCAACACAATGCCCACTCACCTCAGCAACGGACAGATGTGT
GAGTGGCCCCGACCCAGGGGACAGGCAGCCACCCCTGAGACCCCACAGCCCTCACCGCCAGGTGGCTCAGGGTCTGAGCCCTATAAGCTC
CTGCCGGGAGCCGTCGCCACAATCGTCAAGCCCCTCTCTGCCATCCCCCAGCCGACCATCACCAAGCAGGAAGTTATCTAGCAAGCCGCT
GGGGCTTGGGGGCTCCACTGGCTCCCCCCAGCCCCCTAAGAGAGCACCTGGTGATCACGTGGTCACGGCAAAGGAAGACGTGATGCCAGG
ACCAGTCCCAGAGCAGGAATGGGAAGGATGAAGGGCCCGAGAACATGGCCTAAGGGCCACATCCCACTGCCACCCTTGACGCCCTGCTCT
GGATAACAAGACTTTGACTTGGGGAGACCTCTACTGCCTTGGACAACTTTTCTCATGTTGAAGCCACTGCCTTCACCTTCACCTTCATCC
ATGTCCAACCCCCGACTTCATCCCAAAGGACAGCCGCCTGGAGATGACTTGAGGCCTTACTTAAACCCAGCTCCCTTCTTCCCTAGCCTG
GTGCTTCTCCTCTCCTAGCCCCTGTCATGGTGTCCAGACAGAGCCCTGTGAGGCTGGGTCCAATTGTGGCACTTGGGGCACCTTGCTCCT
CCTTCTGCTGCTGCCCCCACCTCTGCTGCCTCCCTCTGCTGTCACCTTGCTCAGCCATCCCGTCTTCTCCAACACCACCTCTCCAGAGGC
CAAGGAGGCCTTGGAAACGATTCCCCCAGTCATTCTGGGAACATGTTGTAAGCACTGACTGGGACCAGGCACCAGGCAGGGTCTAGAAGG
CTGTGGTGAGGGAAGACGCCTTTCTCCTCCAACCCAACCTCATCCTCCTTCTTCAGGGACTTGGGTGGGTACTTGGGTGAGGATCCCTGA
AGGCCTTCAACCCGAGAAAACAAACCCAGGTTGGCGACTGCAACAGGAACTTGGAGTGGAGAGGAAAAGCATCAGAAAGAGGCAGACCAT
CCACCAGGCCTTTGAGAAAGGGTAGAATTCTGGCTGGTAGAGCAGGTGAGATGGGACATTCCAAAGAACAGCCTGAGCCAAGGCCTAGTG
GTAGTAAGAATCTAGCAAGAATTGAGGAAGAATGGTGTGGGAGAGGGATGATGAAGAGAGAGAGGGCCTGCTGGAGAGCATAGGGTCTGG
AACACCAGGCTGAGGTCCTGATCAGCTTCAAGGAGTATGCAGGGAGCTGGGCTTCCAGAAAATGAACACAGCAGTTCTGCAGAGGACGGG
AGGCTGGAAGCTGGGAGGTCAGGTGGGGTGGATGATATAATGCGGGTGAGAGTAATGAGGCTTGGGGCTGGAGAGGACAAGATGGGTAAA
CCCTCACATCAGAGTGACATCCAGGAGGAATAAGCTCCCAGGGCCTGTCTCAAGCTCTTCCTTACTCCCAGGCACTGTCTTAAGGCATCT
GACATGCATCATCTCATTTAATCCTCCCTTCCTCCCTATTAACCTAGAGATTGTTTTTGTTTTTTATTCTCCTCCTCCCTCCCCGCCCTC
ACCCGCCCCACTCCCTCCTAACCTAGAGATTGTTACAGAAGCTGAAATTGCGTTCTAAGAGGTGAAGTGATTTTTTTTCTGAAACTCACA
CAACTAGGAAGTGGCTGAGTCAGGACTTGAACCCAGGTCTCCCTGGATCAGAACAGGAGCTCTTAACTACAGTGGCTGAATAGCTTCTCC
AAAGGCTCCCTGTGTTCTCACCGTGATCAAGTTGAGGGGCTTCCGGCTCCCTTCTACAGCCTCAGAAACCAGACTCGTTCTTCTGGGAAC
CCTGCCCACTCCCAGGACCAAGATTGGCCTGAGGCTGCACTAAAATTCACTTAGGGTCGAGCATCCTGTTTGCTGATAAATATTAAGGAG
AATTCATGACTCTTGACAGCTTTTCTCTCTTCACTCCCCAAGTCAAGGGGAGGGGTGGCAGGGGTCTGTTTCCTGGAAGTCAGGCTCATC
TGGCCTGTTGGCATGGGGGTGGGACAGTGTGCACAGTGTGGGGGCAGGGGAGGGCTAAGCAGGCCTGGGTTTGAGGGCTGCTCCGGAGAC
CGTCACTCCAGGTGCATTCTGGAAGCATTAGACCCCAGGATGGAGCGACCAGCATGTCATCCATGTGGAATCTTGGTGGCTTTGAGGACA
TTCTGGAAAATGCCACTGACCAGTGTGAACAAAAGGGATGTGTTATGGGGCTGGAGGTGTGATTAGGTAGGAGGGAAACTGTTGGACCGA
CTCCTGCCCCCTGCTCAACACTGACCCCTCTGAGTGGTTGGAGGCAGTGCCCCAGTGCCCAGAAATCCCACCATTAGTGATTGTTTTTTA
TGAGAAAGAGGCGTGGAGAAGTATTGGGGCAATGTGTCAGGGAGGAATCACCACATCCCTACGGCAGTCCCAGCCAAGCCCCCAATCCCA
GCGGAGACTGTGCCCTGCTCAGAGCTCCCAAGCCTTCCCCCACCACCTCACTCAAGTGCCCCTGAAATCCCTGCCAGACGGCTCAGCCTG
GTCTGCGGTAAGGCAGGGAGGCTGGAACCATTTCTGGGCATTGTGGTCATTCCCACTGTGTTCCTCCACCTCCTCCCTCCAGCGTTGCTC
AGACCTCTGTCTTGGGAGAAAGGTTGAGATAAGAATGTCCCATGGAGTGCCGTGGGCAACAGTGGCCCTTCATGGGAACAATCTGTTGGA
GCAGGGGGTCAGTTCTCTGCTGGGAATCTACCCCTTTCTGGAGGAGAAACCCATTCCACCTTAATAACTTTATTGTAATGTGAGAAACAC
AAAACAAAGTTTACTTTTTTGACTCTAAGCTGACATGATATTAGAAAATCTCTCGCTCTCTTTTTTTTTTTTTTTTTTTTTTTTGGCTAC
TTGAGTTGTGGTCCTAAAACATAAAATCTGATGGACAAACAGAGGGTTGCTGGGGGGACAAGCGTGGGCACAATTTCCCCACCAAGACAC
CCTGATCTTCAGGCGGGTCTCAGGAGCTTCTAAAAATCCGCATGGCTCTCCTGAGAGTGGACAGAGGAGAGGAGAGGGTCAGAAATGAAC
GCTCTTCTATTTCTTGTCATTACCAAGCCAATTACTTTTGCCAAATTTTTCTGTGATCTGCCCTGATTAAGATGAATTGTGAAATTTACA
TCAAGCAATTATCAAAGCGGGCTGGGTCCCATCAGAACGACCCACATCTTTCTGTGGGTGTGAATGTCATTAGGTCTTGCGCTGACCCCT
GAGCCCCCATCACTGCCGCCTGATGGGGCAAAGAAACAAAAAACATTTCTTACTCTTCTGTGTTTTAACAAAAGTTTATAAAACAAAATA

>5869_5869_1_ARFGEF2-HNF4A_ARFGEF2_chr20_47538547_ENST00000371917_HNF4A_chr20_43034698_ENST00000316099_length(amino acids)=476AA_BP=40
MQESQTKSMFVSRALEKILADKEVKRPQHSQLRRACQVALDTSPSEGTNLNAPNSLGVSALCAICGDRATGKHYGASSCDGCKGFFRRSV
RKNHMYSCRFSRQCVVDKDKRNQCRYCRLKKCFRAGMKKEAVQNERDRISTRRSSYEDSSLPSINALLQAEVLSRQITSPVSGINGDIRA
KKIASIADVCESMKEQLLVLVEWAKYIPAFCELPLDDQVALLRAHAGEHLLLGATKRSMVFKDVLLLGNDYIVPRHCPELAEMSRVSIRI
LDELVLPFQELQIDDNEYAYLKAIIFFDPDAKGLSDPGKIKRLRSQVQVSLEDYINDRQYDSRGRFGELLLLLPTLQSITWQMIEQIQFI
KLFGMAKIDNLLQEMLLGGSPSDAPHAHHPLHPHLMQEHMGTNVIVANTMPTHLSNGQMCEWPRPRGQAATPETPQPSPPGGSGSEPYKL

--------------------------------------------------------------
>5869_5869_2_ARFGEF2-HNF4A_ARFGEF2_chr20_47538547_ENST00000371917_HNF4A_chr20_43034698_ENST00000316673_length(transcript)=1437nt_BP=121nt
ATGCAGGAGAGCCAGACCAAGAGCATGTTCGTGTCCCGGGCCCTGGAGAAGATCCTAGCCGACAAGGAGGTGAAGCGGCCCCAGCACTCC
CAGCTGCGCAGGGCCTGCCAGGTGGCGCTCGACACGTCCCCATCAGAAGGCACCAACCTCAACGCGCCCAACAGCCTGGGTGTCAGCGCC
CTGTGTGCCATCTGCGGGGACCGGGCCACGGGCAAACACTACGGTGCCTCGAGCTGTGACGGCTGCAAGGGCTTCTTCCGGAGGAGCGTG
CGGAAGAACCACATGTACTCCTGCAGATTTAGCCGGCAGTGCGTGGTGGACAAAGACAAGAGGAACCAGTGCCGCTACTGCAGGCTCAAG
AAATGCTTCCGGGCTGGCATGAAGAAGGAAGCCGTCCAGAATGAGCGGGACCGGATCAGCACTCGAAGGTCAAGCTATGAGGACAGCAGC
CTGCCCTCCATCAATGCGCTCCTGCAGGCGGAGGTCCTGTCCCGACAGATCACCTCCCCCGTCTCCGGGATCAACGGCGACATTCGGGCG
AAGAAGATTGCCAGCATCGCAGATGTGTGTGAGTCCATGAAGGAGCAGCTGCTGGTTCTCGTTGAGTGGGCCAAGTACATCCCAGCTTTC
TGCGAGCTCCCCCTGGACGACCAGGTGGCCCTGCTCAGAGCCCATGCTGGCGAGCACCTGCTGCTCGGAGCCACCAAGAGATCCATGGTG
TTCAAGGACGTGCTGCTCCTAGGCAATGACTACATTGTCCCTCGGCACTGCCCGGAGCTGGCGGAGATGAGCCGGGTGTCCATACGCATC
CTTGACGAGCTGGTGCTGCCCTTCCAGGAGCTGCAGATCGATGACAATGAGTATGCCTACCTCAAAGCCATCATCTTCTTTGACCCAGAT
GCCAAGGGGCTGAGCGATCCAGGGAAGATCAAGCGGCTGCGTTCCCAGGTGCAGGTGAGCTTGGAGGACTACATCAACGACCGCCAGTAT
GACTCGCGTGGCCGCTTTGGAGAGCTGCTGCTGCTGCTGCCCACCTTGCAGAGCATCACCTGGCAGATGATCGAGCAGATCCAGTTCATC
AAGCTCTTCGGCATGGCCAAGATTGACAACCTGTTGCAGGAGATGCTGCTGGGAGGGTCCCCCAGCGATGCACCCCATGCCCACCACCCC
CTGCACCCTCACCTGATGCAGGAACATATGGGAACCAACGTCATCGTTGCCAACACAATGCCCACTCACCTCAGCAACGGACAGATGTGT
GAGTGGCCCCGACCCAGGGGACAGGCAGCCACCCCTGAGACCCCACAGCCCTCACCGCCAGGTGGCTCAGGGTCTGAGCCCTATAAGCTC

>5869_5869_2_ARFGEF2-HNF4A_ARFGEF2_chr20_47538547_ENST00000371917_HNF4A_chr20_43034698_ENST00000316673_length(amino acids)=476AA_BP=40
MQESQTKSMFVSRALEKILADKEVKRPQHSQLRRACQVALDTSPSEGTNLNAPNSLGVSALCAICGDRATGKHYGASSCDGCKGFFRRSV
RKNHMYSCRFSRQCVVDKDKRNQCRYCRLKKCFRAGMKKEAVQNERDRISTRRSSYEDSSLPSINALLQAEVLSRQITSPVSGINGDIRA
KKIASIADVCESMKEQLLVLVEWAKYIPAFCELPLDDQVALLRAHAGEHLLLGATKRSMVFKDVLLLGNDYIVPRHCPELAEMSRVSIRI
LDELVLPFQELQIDDNEYAYLKAIIFFDPDAKGLSDPGKIKRLRSQVQVSLEDYINDRQYDSRGRFGELLLLLPTLQSITWQMIEQIQFI
KLFGMAKIDNLLQEMLLGGSPSDAPHAHHPLHPHLMQEHMGTNVIVANTMPTHLSNGQMCEWPRPRGQAATPETPQPSPPGGSGSEPYKL

--------------------------------------------------------------
>5869_5869_3_ARFGEF2-HNF4A_ARFGEF2_chr20_47538547_ENST00000371917_HNF4A_chr20_43034698_ENST00000415691_length(transcript)=2236nt_BP=121nt
ATGCAGGAGAGCCAGACCAAGAGCATGTTCGTGTCCCGGGCCCTGGAGAAGATCCTAGCCGACAAGGAGGTGAAGCGGCCCCAGCACTCC
CAGCTGCGCAGGGCCTGCCAGGTGGCGCTCGACACGTCCCCATCAGAAGGCACCAACCTCAACGCGCCCAACAGCCTGGGTGTCAGCGCC
CTGTGTGCCATCTGCGGGGACCGGGCCACGGGCAAACACTACGGTGCCTCGAGCTGTGACGGCTGCAAGGGCTTCTTCCGGAGGAGCGTG
CGGAAGAACCACATGTACTCCTGCAGATTTAGCCGGCAGTGCGTGGTGGACAAAGACAAGAGGAACCAGTGCCGCTACTGCAGGCTCAAG
AAATGCTTCCGGGCTGGCATGAAGAAGGAAGCCGTCCAGAATGAGCGGGACCGGATCAGCACTCGAAGGTCAAGCTATGAGGACAGCAGC
CTGCCCTCCATCAATGCGCTCCTGCAGGCGGAGGTCCTGTCCCGACAGATCACCTCCCCCGTCTCCGGGATCAACGGCGACATTCGGGCG
AAGAAGATTGCCAGCATCGCAGATGTGTGTGAGTCCATGAAGGAGCAGCTGCTGGTTCTCGTTGAGTGGGCCAAGTACATCCCAGCTTTC
TGCGAGCTCCCCCTGGACGACCAGGTGGCCCTGCTCAGAGCCCATGCTGGCGAGCACCTGCTGCTCGGAGCCACCAAGAGATCCATGGTG
TTCAAGGACGTGCTGCTCCTAGGCAATGACTACATTGTCCCTCGGCACTGCCCGGAGCTGGCGGAGATGAGCCGGGTGTCCATACGCATC
CTTGACGAGCTGGTGCTGCCCTTCCAGGAGCTGCAGATCGATGACAATGAGTATGCCTACCTCAAAGCCATCATCTTCTTTGACCCAGAT
GCCAAGGGGCTGAGCGATCCAGGGAAGATCAAGCGGCTGCGTTCCCAGGTGCAGGTGAGCTTGGAGGACTACATCAACGACCGCCAGTAT
GACTCGCGTGGCCGCTTTGGAGAGCTGCTGCTGCTGCTGCCCACCTTGCAGAGCATCACCTGGCAGATGATCGAGCAGATCCAGTTCATC
AAGCTCTTCGGCATGGCCAAGATTGACAACCTGTTGCAGGAGATGCTGCTGGGAGGGTCCCCCAGCGATGCACCCCATGCCCACCACCCC
CTGCACCCTCACCTGATGCAGGAACATATGGGAACCAACGTCATCGTTGCCAACACAATGCCCACTCACCTCAGCAACGGACAGATGTCC
ACCCCTGAGACCCCACAGCCCTCACCGCCAGGTGGCTCAGGGTCTGAGCCCTATAAGCTCCTGCCGGGAGCCGTCGCCACAATCGTCAAG
CCCCTCTCTGCCATCCCCCAGCCGACCATCACCAAGCAGGAAGTTATCTAGCAAGCCGCTGGGGCTTGGGGGCTCCACTGGCTCCCCCCA
GCCCCCTAAGAGAGCACCTGGTGATCACGTGGTCACGGCAAAGGAAGACGTGATGCCAGGACCAGTCCCAGAGCAGGAATGGGAAGGATG
AAGGGCCCGAGAACATGGCCTAAGGGCCACATCCCACTGCCACCCTTGACGCCCTGCTCTGGATAACAAGACTTTGACTTGGGGAGACCT
CTACTGCCTTGGACAACTTTTCTCATGTTGAAGCCACTGCCTTCACCTTCACCTTCATCCATGTCCAACCCCCGACTTCATCCCAAAGGA
CAGCCGCCTGGAGATGACTTGAGGCCTTACTTAAACCCAGCTCCCTTCTTCCCTAGCCTGGTGCTTCTCCTCTCCTAGCCCCTGTCATGG
TGTCCAGACAGAGCCCTGTGAGGCTGGGTCCAATTGTGGCACTTGGGGCACCTTGCTCCTCCTTCTGCTGCTGCCCCCACCTCTGCTGCC
TCCCTCTGCTGTCACCTTGCTCAGCCATCCCGTCTTCTCCAACACCACCTCTCCAGAGGCCAAGGAGGCCTTGGAAACGATTCCCCCAGT
CATTCTGGGAACATGTTGTAAGCACTGACTGGGACCAGGCACCAGGCAGGGTCTAGAAGGCTGTGGTGAGGGAAGACGCCTTTCTCCTCC
AACCCAACCTCATCCTCCTTCTTCAGGGACTTGGGTGGGTACTTGGGTGAGGATCCCTGAAGGCCTTCAACCCGAGAAAACAAACCCAGG

>5869_5869_3_ARFGEF2-HNF4A_ARFGEF2_chr20_47538547_ENST00000371917_HNF4A_chr20_43034698_ENST00000415691_length(amino acids)=466AA_BP=40
MQESQTKSMFVSRALEKILADKEVKRPQHSQLRRACQVALDTSPSEGTNLNAPNSLGVSALCAICGDRATGKHYGASSCDGCKGFFRRSV
RKNHMYSCRFSRQCVVDKDKRNQCRYCRLKKCFRAGMKKEAVQNERDRISTRRSSYEDSSLPSINALLQAEVLSRQITSPVSGINGDIRA
KKIASIADVCESMKEQLLVLVEWAKYIPAFCELPLDDQVALLRAHAGEHLLLGATKRSMVFKDVLLLGNDYIVPRHCPELAEMSRVSIRI
LDELVLPFQELQIDDNEYAYLKAIIFFDPDAKGLSDPGKIKRLRSQVQVSLEDYINDRQYDSRGRFGELLLLLPTLQSITWQMIEQIQFI
KLFGMAKIDNLLQEMLLGGSPSDAPHAHHPLHPHLMQEHMGTNVIVANTMPTHLSNGQMSTPETPQPSPPGGSGSEPYKLLPGAVATIVK

--------------------------------------------------------------
>5869_5869_4_ARFGEF2-HNF4A_ARFGEF2_chr20_47538547_ENST00000371917_HNF4A_chr20_43034698_ENST00000443598_length(transcript)=1520nt_BP=121nt
ATGCAGGAGAGCCAGACCAAGAGCATGTTCGTGTCCCGGGCCCTGGAGAAGATCCTAGCCGACAAGGAGGTGAAGCGGCCCCAGCACTCC
CAGCTGCGCAGGGCCTGCCAGGTGGCGCTCGACACGTCCCCATCAGAAGGCACCAACCTCAACGCGCCCAACAGCCTGGGTGTCAGCGCC
CTGTGTGCCATCTGCGGGGACCGGGCCACGGGCAAACACTACGGTGCCTCGAGCTGTGACGGCTGCAAGGGCTTCTTCCGGAGGAGCGTG
CGGAAGAACCACATGTACTCCTGCAGATTTAGCCGGCAGTGCGTGGTGGACAAAGACAAGAGGAACCAGTGCCGCTACTGCAGGCTCAAG
AAATGCTTCCGGGCTGGCATGAAGAAGGAAGCCGTCCAGAATGAGCGGGACCGGATCAGCACTCGAAGGTCAAGCTATGAGGACAGCAGC
CTGCCCTCCATCAATGCGCTCCTGCAGGCGGAGGTCCTGTCCCGACAGATCACCTCCCCCGTCTCCGGGATCAACGGCGACATTCGGGCG
AAGAAGATTGCCAGCATCGCAGATGTGTGTGAGTCCATGAAGGAGCAGCTGCTGGTTCTCGTTGAGTGGGCCAAGTACATCCCAGCTTTC
TGCGAGCTCCCCCTGGACGACCAGGTGGCCCTGCTCAGAGCCCATGCTGGCGAGCACCTGCTGCTCGGAGCCACCAAGAGATCCATGGTG
TTCAAGGACGTGCTGCTCCTAGGCAATGACTACATTGTCCCTCGGCACTGCCCGGAGCTGGCGGAGATGAGCCGGGTGTCCATACGCATC
CTTGACGAGCTGGTGCTGCCCTTCCAGGAGCTGCAGATCGATGACAATGAGTATGCCTACCTCAAAGCCATCATCTTCTTTGACCCAGAT
GCCAAGGGGCTGAGCGATCCAGGGAAGATCAAGCGGCTGCGTTCCCAGGTGCAGGTGAGCTTGGAGGACTACATCAACGACCGCCAGTAT
GACTCGCGTGGCCGCTTTGGAGAGCTGCTGCTGCTGCTGCCCACCTTGCAGAGCATCACCTGGCAGATGATCGAGCAGATCCAGTTCATC
AAGCTCTTCGGCATGGCCAAGATTGACAACCTGTTGCAGGAGATGCTGCTGGGAGGTCCGTGCCAAGCCCAGGAGGGGCGGGGTTGGAGT
GGGGACTCCCCAGGAGACAGGCCTCACACAGTGAGCTCACCCCTCAGCTCCTTGGCTTCCCCACTGTGCCGCTTTGGGCAAGTTGCTTAA
CCTGTCTGTGCCTCAGTTTCCTCACCAGAAAAATGGGAACAAGGCAATGGTCTATTTGTTCAGGCACCGAGAACCTAGCACGTGCCAGTC
ACTGTTCTAAGTGCTGGCAATTCAGCAAAGAACAAGATCTTTGCCCTCGGGGAGGCTGTGTGTGTGTGAGTATGTATGGATGCGTGGATA

>5869_5869_4_ARFGEF2-HNF4A_ARFGEF2_chr20_47538547_ENST00000371917_HNF4A_chr20_43034698_ENST00000443598_length(amino acids)=419AA_BP=40
MQESQTKSMFVSRALEKILADKEVKRPQHSQLRRACQVALDTSPSEGTNLNAPNSLGVSALCAICGDRATGKHYGASSCDGCKGFFRRSV
RKNHMYSCRFSRQCVVDKDKRNQCRYCRLKKCFRAGMKKEAVQNERDRISTRRSSYEDSSLPSINALLQAEVLSRQITSPVSGINGDIRA
KKIASIADVCESMKEQLLVLVEWAKYIPAFCELPLDDQVALLRAHAGEHLLLGATKRSMVFKDVLLLGNDYIVPRHCPELAEMSRVSIRI
LDELVLPFQELQIDDNEYAYLKAIIFFDPDAKGLSDPGKIKRLRSQVQVSLEDYINDRQYDSRGRFGELLLLLPTLQSITWQMIEQIQFI

--------------------------------------------------------------
>5869_5869_5_ARFGEF2-HNF4A_ARFGEF2_chr20_47538547_ENST00000371917_HNF4A_chr20_43034698_ENST00000457232_length(transcript)=1407nt_BP=121nt
ATGCAGGAGAGCCAGACCAAGAGCATGTTCGTGTCCCGGGCCCTGGAGAAGATCCTAGCCGACAAGGAGGTGAAGCGGCCCCAGCACTCC
CAGCTGCGCAGGGCCTGCCAGGTGGCGCTCGACACGTCCCCATCAGAAGGCACCAACCTCAACGCGCCCAACAGCCTGGGTGTCAGCGCC
CTGTGTGCCATCTGCGGGGACCGGGCCACGGGCAAACACTACGGTGCCTCGAGCTGTGACGGCTGCAAGGGCTTCTTCCGGAGGAGCGTG
CGGAAGAACCACATGTACTCCTGCAGATTTAGCCGGCAGTGCGTGGTGGACAAAGACAAGAGGAACCAGTGCCGCTACTGCAGGCTCAAG
AAATGCTTCCGGGCTGGCATGAAGAAGGAAGCCGTCCAGAATGAGCGGGACCGGATCAGCACTCGAAGGTCAAGCTATGAGGACAGCAGC
CTGCCCTCCATCAATGCGCTCCTGCAGGCGGAGGTCCTGTCCCGACAGATCACCTCCCCCGTCTCCGGGATCAACGGCGACATTCGGGCG
AAGAAGATTGCCAGCATCGCAGATGTGTGTGAGTCCATGAAGGAGCAGCTGCTGGTTCTCGTTGAGTGGGCCAAGTACATCCCAGCTTTC
TGCGAGCTCCCCCTGGACGACCAGGTGGCCCTGCTCAGAGCCCATGCTGGCGAGCACCTGCTGCTCGGAGCCACCAAGAGATCCATGGTG
TTCAAGGACGTGCTGCTCCTAGGCAATGACTACATTGTCCCTCGGCACTGCCCGGAGCTGGCGGAGATGAGCCGGGTGTCCATACGCATC
CTTGACGAGCTGGTGCTGCCCTTCCAGGAGCTGCAGATCGATGACAATGAGTATGCCTACCTCAAAGCCATCATCTTCTTTGACCCAGAT
GCCAAGGGGCTGAGCGATCCAGGGAAGATCAAGCGGCTGCGTTCCCAGGTGCAGGTGAGCTTGGAGGACTACATCAACGACCGCCAGTAT
GACTCGCGTGGCCGCTTTGGAGAGCTGCTGCTGCTGCTGCCCACCTTGCAGAGCATCACCTGGCAGATGATCGAGCAGATCCAGTTCATC
AAGCTCTTCGGCATGGCCAAGATTGACAACCTGTTGCAGGAGATGCTGCTGGGAGGGTCCCCCAGCGATGCACCCCATGCCCACCACCCC
CTGCACCCTCACCTGATGCAGGAACATATGGGAACCAACGTCATCGTTGCCAACACAATGCCCACTCACCTCAGCAACGGACAGATGTCC
ACCCCTGAGACCCCACAGCCCTCACCGCCAGGTGGCTCAGGGTCTGAGCCCTATAAGCTCCTGCCGGGAGCCGTCGCCACAATCGTCAAG

>5869_5869_5_ARFGEF2-HNF4A_ARFGEF2_chr20_47538547_ENST00000371917_HNF4A_chr20_43034698_ENST00000457232_length(amino acids)=466AA_BP=40
MQESQTKSMFVSRALEKILADKEVKRPQHSQLRRACQVALDTSPSEGTNLNAPNSLGVSALCAICGDRATGKHYGASSCDGCKGFFRRSV
RKNHMYSCRFSRQCVVDKDKRNQCRYCRLKKCFRAGMKKEAVQNERDRISTRRSSYEDSSLPSINALLQAEVLSRQITSPVSGINGDIRA
KKIASIADVCESMKEQLLVLVEWAKYIPAFCELPLDDQVALLRAHAGEHLLLGATKRSMVFKDVLLLGNDYIVPRHCPELAEMSRVSIRI
LDELVLPFQELQIDDNEYAYLKAIIFFDPDAKGLSDPGKIKRLRSQVQVSLEDYINDRQYDSRGRFGELLLLLPTLQSITWQMIEQIQFI
KLFGMAKIDNLLQEMLLGGSPSDAPHAHHPLHPHLMQEHMGTNVIVANTMPTHLSNGQMSTPETPQPSPPGGSGSEPYKLLPGAVATIVK

--------------------------------------------------------------
>5869_5869_6_ARFGEF2-HNF4A_ARFGEF2_chr20_47538547_ENST00000371917_HNF4A_chr20_43034698_ENST00000609795_length(transcript)=1260nt_BP=121nt
ATGCAGGAGAGCCAGACCAAGAGCATGTTCGTGTCCCGGGCCCTGGAGAAGATCCTAGCCGACAAGGAGGTGAAGCGGCCCCAGCACTCC
CAGCTGCGCAGGGCCTGCCAGGTGGCGCTCGACACGTCCCCATCAGAAGGCACCAACCTCAACGCGCCCAACAGCCTGGGTGTCAGCGCC
CTGTGTGCCATCTGCGGGGACCGGGCCACGGGCAAACACTACGGTGCCTCGAGCTGTGACGGCTGCAAGGGCTTCTTCCGGAGGAGCGTG
CGGAAGAACCACATGTACTCCTGCAGATTTAGCCGGCAGTGCGTGGTGGACAAAGACAAGAGGAACCAGTGCCGCTACTGCAGGCTCAAG
AAATGCTTCCGGGCTGGCATGAAGAAGGAAGCCGTCCAGAATGAGCGGGACCGGATCAGCACTCGAAGGTCAAGCTATGAGGACAGCAGC
CTGCCCTCCATCAATGCGCTCCTGCAGGCGGAGGTCCTGTCCCGACAGATCACCTCCCCCGTCTCCGGGATCAACGGCGACATTCGGGCG
AAGAAGATTGCCAGCATCGCAGATGTGTGTGAGTCCATGAAGGAGCAGCTGCTGGTTCTCGTTGAGTGGGCCAAGTACATCCCAGCTTTC
TGCGAGCTCCCCCTGGACGACCAGGTGGCCCTGCTCAGAGCCCATGCTGGCGAGCACCTGCTGCTCGGAGCCACCAAGAGATCCATGGTG
TTCAAGGACGTGCTGCTCCTAGGCAATGACTACATTGTCCCTCGGCACTGCCCGGAGCTGGCGGAGATGAGCCGGGTGTCCATACGCATC
CTTGACGAGCTGGTGCTGCCCTTCCAGGAGCTGCAGATCGATGACAATGAGTATGCCTACCTCAAAGCCATCATCTTCTTTGACCCAGAT
GCCAAGGGGCTGAGCGATCCAGGGAAGATCAAGCGGCTGCGTTCCCAGGTGCAGGTGAGCTTGGAGGACTACATCAACGACCGCCAGTAT
GACTCGCGTGGCCGCTTTGGAGAGCTGCTGCTGCTGCTGCCCACCTTGCAGAGCATCACCTGGCAGATGATCGAGCAGATCCAGTTCATC
AAGCTCTTCGGCATGGCCAAGATTGACAACCTGTTGCAGGAGATGCTGCTGGGAGGTCCGTGCCAAGCCCAGGAGGGGCGGGGTTGGAGT
GGGGACTCCCCAGGAGACAGGCCTCACACAGTGAGCTCACCCCTCAGCTCCTTGGCTTCCCCACTGTGCCGCTTTGGGCAAGTTGCTTAA

>5869_5869_6_ARFGEF2-HNF4A_ARFGEF2_chr20_47538547_ENST00000371917_HNF4A_chr20_43034698_ENST00000609795_length(amino acids)=419AA_BP=40
MQESQTKSMFVSRALEKILADKEVKRPQHSQLRRACQVALDTSPSEGTNLNAPNSLGVSALCAICGDRATGKHYGASSCDGCKGFFRRSV
RKNHMYSCRFSRQCVVDKDKRNQCRYCRLKKCFRAGMKKEAVQNERDRISTRRSSYEDSSLPSINALLQAEVLSRQITSPVSGINGDIRA
KKIASIADVCESMKEQLLVLVEWAKYIPAFCELPLDDQVALLRAHAGEHLLLGATKRSMVFKDVLLLGNDYIVPRHCPELAEMSRVSIRI
LDELVLPFQELQIDDNEYAYLKAIIFFDPDAKGLSDPGKIKRLRSQVQVSLEDYINDRQYDSRGRFGELLLLLPTLQSITWQMIEQIQFI

--------------------------------------------------------------

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Fusion Gene PPI Analysis for ARFGEF2-HNF4A


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ARFGEF2-HNF4A


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ARFGEF2-HNF4A


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneARFGEF2C1842563Heterotopia, Periventricular, Autosomal Recessive3CTD_human;GENOMICS_ENGLAND;UNIPROT
HgeneARFGEF2C1868720Periventricular Nodular Heterotopia2GENOMICS_ENGLAND;ORPHANET
TgeneC1852093Maturity-Onset Diabetes of the Young, Type 18CTD_human;GENOMICS_ENGLAND;UNIPROT
TgeneC3888631Monogenic diabetes7CLINGEN;GENOMICS_ENGLAND
TgeneC0011860Diabetes Mellitus, Non-Insulin-Dependent5CTD_human;GENOMICS_ENGLAND;UNIPROT
TgeneC4014962FANCONI RENOTUBULAR SYNDROME 4 WITH MATURITY-ONSET DIABETES OF THE YOUNG5CTD_human;GENOMICS_ENGLAND;UNIPROT
TgeneC0342276Maturity onset diabetes mellitus in young2GENOMICS_ENGLAND;ORPHANET
TgeneC4274078Hyperinsulinism due to HNF4A deficiency2ORPHANET
TgeneC0009324Ulcerative Colitis1CTD_human
TgeneC0431693Renal cysts and diabetes syndrome1ORPHANET