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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
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Fusion gene:ARFGEF1-SORCS2 (FusionGDB2 ID:HG10565TG57537)

Fusion Gene Summary for ARFGEF1-SORCS2

Fusion gene summary

Fusion gene information	Fusion gene name: ARFGEF1-SORCS2
	Fusion gene ID: hg10565tg57537
		Hgene	Tgene
	Gene symbol	ARFGEF1	SORCS2
	Gene ID	10565	57537
	Gene name	ADP ribosylation factor guanine nucleotide exchange factor 1	sortilin related VPS10 domain containing receptor 2
	Synonyms	ARFGEP1\|BIG1\|P200	-
	Cytomap	('ARFGEF1')('SORCS2') 8q13.2	4p16.1
	Type of gene	protein-coding	protein-coding
	Description	brefeldin A-inhibited guanine nucleotide-exchange protein 1ADP-ribosylation factor guanine nucleotide-exchange factor 1 (brefeldin A-inhibited)p200 ARF guanine nucleotide exchange factor	VPS10 domain-containing receptor SorCS2VPS10 domain receptor protein
	Modification date	20200313	20200313
	UniProtAcc	.	.
	Ensembl transtripts involved in fusion gene	ENST00000262215, ENST00000517955, ENST00000518230, ENST00000520381,
Fusion gene scores	* DoF score	14 X 14 X 6=1176	6 X 5 X 6=180
	# samples	17	8
	** MAII score	log2(17/1176*10)=-2.79028140869866 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(8/180*10)=-1.16992500144231 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: ARFGEF1 [Title/Abstract] AND SORCS2 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	ARFGEF1(68255398)-SORCS2(7398014), # samples:1 ARFGEF1(68255399)-SORCS2(7398015), # samples:1
Anticipated loss of major functional domain due to fusion event.	ARFGEF1-SORCS2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. ARFGEF1-SORCS2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. ARFGEF1-SORCS2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. ARFGEF1-SORCS2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	ARFGEF1	GO:0034260	negative regulation of GTPase activity	15644318

Fusion gene breakpoints across ARFGEF1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across SORCS2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	SARC	TCGA-DX-A48O-01A	ARFGEF1	chr8	68255399	-	SORCS2	chr4	7398015	+
ChimerDB4	SARC	TCGA-DX-A48O	ARFGEF1	chr8	68255398	-	SORCS2	chr4	7398014	+

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Fusion Gene ORF analysis for ARFGEF1-SORCS2

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-3UTR	ENST00000262215	ENST00000511199	ARFGEF1	chr8	68255399	-	SORCS2	chr4	7398015	+
5CDS-3UTR	ENST00000262215	ENST00000511199	ARFGEF1	chr8	68255398	-	SORCS2	chr4	7398014	+
5CDS-5UTR	ENST00000262215	ENST00000329016	ARFGEF1	chr8	68255399	-	SORCS2	chr4	7398015	+
5CDS-5UTR	ENST00000262215	ENST00000329016	ARFGEF1	chr8	68255398	-	SORCS2	chr4	7398014	+
In-frame	ENST00000262215	ENST00000507866	ARFGEF1	chr8	68255399	-	SORCS2	chr4	7398015	+
In-frame	ENST00000262215	ENST00000507866	ARFGEF1	chr8	68255398	-	SORCS2	chr4	7398014	+
intron-3CDS	ENST00000517955	ENST00000507866	ARFGEF1	chr8	68255399	-	SORCS2	chr4	7398015	+
intron-3CDS	ENST00000517955	ENST00000507866	ARFGEF1	chr8	68255398	-	SORCS2	chr4	7398014	+
intron-3CDS	ENST00000518230	ENST00000507866	ARFGEF1	chr8	68255399	-	SORCS2	chr4	7398015	+
intron-3CDS	ENST00000518230	ENST00000507866	ARFGEF1	chr8	68255398	-	SORCS2	chr4	7398014	+
intron-3CDS	ENST00000520381	ENST00000507866	ARFGEF1	chr8	68255399	-	SORCS2	chr4	7398015	+
intron-3CDS	ENST00000520381	ENST00000507866	ARFGEF1	chr8	68255398	-	SORCS2	chr4	7398014	+
intron-3UTR	ENST00000517955	ENST00000511199	ARFGEF1	chr8	68255399	-	SORCS2	chr4	7398015	+
intron-3UTR	ENST00000517955	ENST00000511199	ARFGEF1	chr8	68255398	-	SORCS2	chr4	7398014	+
intron-3UTR	ENST00000518230	ENST00000511199	ARFGEF1	chr8	68255399	-	SORCS2	chr4	7398015	+
intron-3UTR	ENST00000518230	ENST00000511199	ARFGEF1	chr8	68255398	-	SORCS2	chr4	7398014	+
intron-3UTR	ENST00000520381	ENST00000511199	ARFGEF1	chr8	68255399	-	SORCS2	chr4	7398015	+
intron-3UTR	ENST00000520381	ENST00000511199	ARFGEF1	chr8	68255398	-	SORCS2	chr4	7398014	+
intron-5UTR	ENST00000517955	ENST00000329016	ARFGEF1	chr8	68255399	-	SORCS2	chr4	7398015	+
intron-5UTR	ENST00000517955	ENST00000329016	ARFGEF1	chr8	68255398	-	SORCS2	chr4	7398014	+
intron-5UTR	ENST00000518230	ENST00000329016	ARFGEF1	chr8	68255399	-	SORCS2	chr4	7398015	+
intron-5UTR	ENST00000518230	ENST00000329016	ARFGEF1	chr8	68255398	-	SORCS2	chr4	7398014	+
intron-5UTR	ENST00000520381	ENST00000329016	ARFGEF1	chr8	68255399	-	SORCS2	chr4	7398015	+
intron-5UTR	ENST00000520381	ENST00000329016	ARFGEF1	chr8	68255398	-	SORCS2	chr4	7398014	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

ENST00000262215

ARFGEF1

chr8

68255398

ENST00000507866

SORCS2

chr4

7398014

6077

514

520

3513

997

ENST00000262215

ARFGEF1

chr8

68255399

ENST00000507866

SORCS2

chr4

7398015

6077

514

520

3513

997

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000262215	ENST00000507866	ARFGEF1	chr8	68255398	-	SORCS2	chr4	7398014	+	0.001348349	0.9986517
ENST00000262215	ENST00000507866	ARFGEF1	chr8	68255399	-	SORCS2	chr4	7398015	+	0.001348349	0.9986517

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Fusion Genomic Features for ARFGEF1-SORCS2

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
ARFGEF1	chr8	68255398	-	SORCS2	chr4	7398014	+	7.59E-08	0.9999999
ARFGEF1	chr8	68255398	-	SORCS2	chr4	7398014	+	7.59E-08	0.9999999
ARFGEF1	chr8	68255398	-	SORCS2	chr4	7398014	+	7.59E-08	0.9999999
ARFGEF1	chr8	68255398	-	SORCS2	chr4	7398014	+	7.59E-08	0.9999999

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for ARFGEF1-SORCS2

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr8:68255398/chr4:7398014)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

SORCS2

chr8:68255398

chr4:7398014

ENST00000507866

786_876

160

1160.0

Domain

PKD

Tgene

SORCS2

chr8:68255399

chr4:7398015

ENST00000507866

786_876

160

1160.0

Domain

PKD

Tgene

SORCS2

chr8:68255398

chr4:7398014

ENST00000507866

182_193

160

1160.0

Repeat

Note=BNR 1

Tgene

SORCS2

chr8:68255398

chr4:7398014

ENST00000507866

232_243

160

1160.0

Repeat

Note=BNR 2

Tgene

SORCS2

chr8:68255398

chr4:7398014

ENST00000507866

273_284

160

1160.0

Repeat

Note=BNR 3

Tgene

SORCS2

chr8:68255398

chr4:7398014

ENST00000507866

468_479

160

1160.0

Repeat

Note=BNR 4

Tgene

SORCS2

chr8:68255398

chr4:7398014

ENST00000507866

545_556

160

1160.0

Repeat

Note=BNR 5

Tgene

SORCS2

chr8:68255398

chr4:7398014

ENST00000507866

587_598

160

1160.0

Repeat

Note=BNR 6

Tgene

SORCS2

chr8:68255399

chr4:7398015

ENST00000507866

182_193

160

1160.0

Repeat

Note=BNR 1

Tgene

SORCS2

chr8:68255399

chr4:7398015

ENST00000507866

232_243

160

1160.0

Repeat

Note=BNR 2

Tgene

SORCS2

chr8:68255399

chr4:7398015

ENST00000507866

273_284

160

1160.0

Repeat

Note=BNR 3

Tgene

SORCS2

chr8:68255399

chr4:7398015

ENST00000507866

468_479

160

1160.0

Repeat

Note=BNR 4

Tgene

SORCS2

chr8:68255399

chr4:7398015

ENST00000507866

545_556

160

1160.0

Repeat

Note=BNR 5

Tgene

SORCS2

chr8:68255399

chr4:7398015

ENST00000507866

587_598

160

1160.0

Repeat

Note=BNR 6

Tgene

SORCS2

chr8:68255398

chr4:7398014

ENST00000507866

1100_1159

160

1160.0

Topological domain

Cytoplasmic

Tgene

SORCS2

chr8:68255399

chr4:7398015

ENST00000507866

1100_1159

160

1160.0

Topological domain

Cytoplasmic

Tgene

SORCS2

chr8:68255398

chr4:7398014

ENST00000507866

1079_1099

160

1160.0

Transmembrane

Helical

Tgene

SORCS2

chr8:68255399

chr4:7398015

ENST00000507866

1079_1099

160

1160.0

Transmembrane

Helical

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

ARFGEF1

chr8:68255398

chr4:7398014

ENST00000262215

709_840

1850.0

Domain

SEC7

Hgene

ARFGEF1

chr8:68255399

chr4:7398015

ENST00000262215

709_840

1850.0

Domain

SEC7

Hgene

ARFGEF1

chr8:68255398

chr4:7398014

ENST00000262215

711_715

1850.0

Motif

Note=Nuclear localization signal (NLS)

Hgene

ARFGEF1

chr8:68255399

chr4:7398015

ENST00000262215

711_715

1850.0

Motif

Note=Nuclear localization signal (NLS)

Tgene

SORCS2

chr8:68255398

chr4:7398014

ENST00000507866

13_104

160

1160.0

Compositional bias

Note=Pro-rich

Tgene

SORCS2

chr8:68255399

chr4:7398015

ENST00000507866

13_104

160

1160.0

Compositional bias

Note=Pro-rich

Tgene

SORCS2

chr8:68255398

chr4:7398014

ENST00000507866

51_1078

160

1160.0

Topological domain

Extracellular

Tgene

SORCS2

chr8:68255399

chr4:7398015

ENST00000507866

51_1078

160

1160.0

Topological domain

Extracellular

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Fusion Gene Sequence for ARFGEF1-SORCS2

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>5863_5863_1_ARFGEF1-SORCS2_ARFGEF1_chr8_68255398_ENST00000262215_SORCS2_chr4_7398014_ENST00000507866_length(transcript)=6077nt_BP=514nt
GCGGTGCCTCTGAGAGCCGCCGCCACCTCGTCCCTCAGTTCCCGGCAGACAGCCGCCCGGGCCGGGCTCCCTCACCGCCACCAGGGCCGG
AGGGACGAGTGAGAGGGGCGGCCGGGACGCGACCCCCGGGCCGGGAGAAGCGGAGGCCCGACGGGCGCGGCCCTCGAGGTACGGCTTCTT
GGGGGCGGCGAGGACCTCGACGCCCTTCGCCGACACCGCGGCTGGTCCCGCTCGCCCGCCCCTTCCTGATCCTGCCGCTGCCCTCCACGC
CTCCAATCCCCCACCTCCACCCCCTCTCCTTTCTCTCTTCTCTTCCTTCCTCTCCTCCTCCTCCCCTCCAGCCGCTGGGAGCCGCGGGTC
GGACGAGCCGCCGCCTCCTTCTCTGCGTCCATGTATGAGGGGAAGAAGACGAAGAACATGTTCCTGACCCGGGCTCTGGAGAAGATATTG
GCCGACAAGGAAGTGAAGAAGGCGCATCACTCCCAGCTGCGCAAAGCTTGCGAGGTGGCGTTAGGTGATCTTGATCCTGACGAAGTACTA
CCACGCAGACATGGGGAAGGTTCTGGAAAGTTCTCTGTGGCGGTCATCAGATTTCGGGACGTCCTACACCAAGCTCACCCTCCAGCCTGG
TGTCACCACCGTCATCGACAATTTCTACATCTGCCCGACCAACAAGAGGAAGGTCATCCTTGTCAGCTCCTCACTCAGTGACCGGGACCA
GAGCCTATTCCTCAGCGCAGACGAAGGCGCCACCTTTCAGAAGCAGCCCATTCCCTTCTTCGTGGAAACTCTGATTTTCCACCCTAAGGA
GGAGGACAAGGTCCTCGCCTACACAAAGGAGAGCAAGCTCTACGTGTCATCTGACTTGGGGAAAAAGTGGACACTTCTGCAAGAGCGAGT
GACCAAAGACCACGTGTTCTGGTCTGTGTCTGGGGTGGACGCTGACCCTGACTTGGTCCACGTGGAAGCCCAAGACCTCGGTGGAGATTT
TCGGTACGTCACCTGCGCAATCCACAATTGCTCCGAGAAGATGCTGACAGCCCCATTCGCAGGCCCCATTGACCACGGGTCTCTGACCGT
GCAGGACGATTACATCTTCTTTAAGGCAACATCAGCAAACCAGACAAAATACTACGTCTCTTATCGTCGAAATGAATTTGTCCTGATGAA
GCTGCCGAAGTATGCATTGCCAAAGGATCTGCAGATCATCAGCACGGACGAGAGTCAGGTGTTCGTGGCGGTGCAGGAGTGGTACCAGAT
GGACACCTACAACCTGTACCAGTCGGACCCACGGGGCGTGCGCTACGCGCTGGTGCTGCAGGACGTGCGCAGCTCACGGCAGGCGGAGGA
GAGCGTGCTCATCGACATCCTGGAGGTCAGAGGGGTGAAAGGAGTCTTCCTGGCAAACCAAAAAATTGATGGGAAAGTGATGACGCTTAT
AACCTACAACAAGGGCCGCGACTGGGATTACCTGAGGCCACCCAGCATGGACATGAATGGAAAACCAACCAACTGCAAGCCTCCAGACTG
CCACCTGCACCTGCACCTGCGCTGGGCAGACAACCCCTACGTATCAGGCACCGTGCACACCAAGGACACCGCCCCAGGCCTCATCATGGG
TGCAGGTAACCTGGGCTCACAGCTGGTGGAATATAAAGAAGAAATGTACATCACGTCAGACTGTGGTCACACCTGGCGGCAGGTGTTTGA
GGAAGAGCATCACATCCTGTACCTGGACCACGGCGGCGTGATCGTGGCCATCAAAGACACCTCCATCCCTTTGAAGATCCTCAAGTTCAG
TGTGGACGAGGGCCTCACCTGGAGCACGCACAACTTCACCAGCACCTCGGTGTTTGTGGACGGGCTGCTGAGTGAGCCAGGGGACGAGAC
GCTGGTCATGACGGTCTTTGGCCACATCAGCTTCCGCTCCGATTGGGAGCTGGTCAAGGTGGACTTCCGGCCCTCATTCTCCAGGCAGTG
CGGCGAGGAGGACTACAGCTCCTGGGAGCTCTCCAACCTGCAGGGCGACCGCTGTATCATGGGCCAGCAGAGAAGTTTCCGGAAAAGAAA
GTCCACGTCCTGGTGCATCAAGGGGAGGAGCTTCACGTCGGCGCTCACGTCCCGCGTGTGCGAGTGCCGGGACTCGGACTTCCTGTGCGA
CTACGGATTTGAGCGCTCCTCCTCCTCAGAGTCCAGCACCAACAAGTGCTCTGCCAACTTCTGGTTTAACCCATTGTCCCCGCCTGACGA
CTGTGCCCTGGGCCAGACCTACACCAGCAGCCTTGGGTACCGGAAAGTGGTGTCCAACGTGTGTGAGGGTGGGGTGGACATGCAGCAGAG
TCAGGTGCAGCTGCAGTGCCCCCTCACGCCGCCCCGGGGCCTGCAGGTCAGCATTCAAGGCGAGGCGGTGGCCGTGCGGCCTGGAGAGGA
CGTCCTGTTTGTGGTGCGGCAGGAGCAGGGTGATGTCCTGACTACCAAGTACCAGGTAGACCTTGGGGACGGCTTCAAGGCCATGTACGT
GAACCTTACACTGACCGGGGAGCCCATCCGGCACCGCTACGAGAGCCCCGGCATCTACCGCGTGTCCGTCAGGGCAGAGAACACGGCAGG
CCACGATGAGGCGGTGCTCTTTGTCCAGGTCAACTCCCCCCTGCAGGCCCTCTACCTGGAGGTGGTTCCTGTCATTGGCCTCAACCAGGA
GGTGAACCTCACAGCTGTGCTGCTTCCCTTGAACCCTAACCTCACCGTCTTCTACTGGTGGATCGGCCACAGCCTGCAGCCCCTCCTTTC
CCTGGATAATTCTGTGACAACGCGGTTTTCGGACACGGGCGACGTGCGTGTGACGGTGCAGGCCGCCTGTGGGAACTCGGTGCTGCAGGA
CTCCAGGGTCCTCCGTGTGCTGGATCAATTTCAAGTCATGCCTCTGCAGTTTTCCAAGGAGCTGGATGCCTACAACCCCAACACCCCTGA
GTGGAGGGAAGACGTGGGCCTGGTGGTCACCCGGCTGCTCTCCAAGGAGACCAGCGTCCCTCAGGAGCTTCTGGTGACTGTGGTGAAGCC
GGGGCTGCCCACTTTGGCCGATCTGTACGTGCTCCTGCCCCCTCCCAGGCCCACAAGGAAGAGGAGCCTCTCGAGTGATAAGAGGCTCGC
CGCCATCCAGCAGGTGCTGAACGCACAGAAGATCAGCTTCCTCCTGCGAGGCGGAGTCCGGGTCCTGGTGGCCCTGCGGGACACAGGCAC
AGGTGCTGAGCAGCTGGGCGGCGGTGGCGGCTACTGGGCGGTAGTGGTGCTGTTTGTCATCGGGCTCTTCGCAGCGGGAGCCTTCATCCT
CTACAAGTTCAAAAGGAAACGGCCAGGCAGGACCGTGTACGCCCAAATGCACAACGAGAAGGAGCAGGAGATGACCAGCCCTGTGAGTCA
CAGTGAGGACGTCCAGGGCGCTGTCCAGGGCAACCACTCAGGCGTGGTCCTGAGCATCAACTCCCGAGAGATGCACAGCTACCTGGTGAG
CTGATGCCACCCCAGCATCTGTCTTTTCACCCACGGAGGGCACAGAACCACCAGCAAAGCCGGCGGCTGGACTGGCGCCCCTCAGAGACC
TGCGGAAAGCCCCCTCCCTGAGTCGTCGCCACACCAGGCGACAGGCACCACCCCCTCTGATAAATCCAAGCCCGCCCAGGCCCACGGGGG
GCCCACGGGACCCCCCGGGACTCCCCGGACATGGCCCTGCCCCTATGGGACACCAGGCCTGACTCAGGCAGGTTCTGCCCCCCAGACCCC
ACACACGGCCGCCCCACGTGCTGTCGCTCAGCCCGAGGCCTGACTTCTCTGGGCTGAGGCTGGTCGTCCTGGAGCCCTCCCAGTACCTCG
GGCTGCAAGAGCTGCAGACCCGTTCAGACACTGCGTTGCGGGCTCCTTCCCCGCAGAGGCCGGGGCCTCCCTGACTTTGCTTCTTCACTC
CCACCTGTGCGGCCACCCAGTCCCTCTGTGGGAGCCCGGGTGCCAGGCCCTCCCAACACCACACCACCCTCCAGGCCCCCCTGCCCTCCG
GCTGGAAACTGCAGCTCTGTAAATGCCTCTCTAGGTAGCTGCTGGCGGTGGTGGGGGTGTCTCACTCTCTGTCTTTATAGCCGGCGGTAG
CCACCGGGGTGGCTCTGTCAGAGTTCCGTACTCGGGAGCCCCTTTCCCTGAGTGCCCAGGGTGTCTCCTCTGCCCAGAGGGGCAGCAGCT
CTCCCTGGTTCTCCCCAGGGCAGACGGGGTAGGGCGGGCTCAGGACCCAGTGCCCATGGTTCCTCACTCCTACCAGCAAGCAGCACCATC
CCGCAGGCTTCTCCCACCTGATGGCTGTTCTCCCACCGGGTCTGGGCTCTGGAAGGAGCCAGATGCCCCCAGAAAGGTGGGTGGTGGAGA
CGGCACCAGATGTACCAGTTTTCTGCAGTTCCTTATAGGCGAAGGGAACCGGGTGGAAACCAAGCTGGGAGAGGCTGAGGATGGCAGGGC
TGGAAGGGCCATCAGCGTGACCCTCATTTTCAAGAAGGGGAAACTGAGGCCCAGGGAGGAGAGTAACTGAAGGTCACAGCACGGTCACAG
CAGAGGTGGCCGAACCCAGCCCTCTGCGCGCCAGTGCTGTGCGGTCTCCACACCCTTACGGTTTCCTAGAATCAGGGATGTTAGTGTAAG
TCTATAGGAATATAGGGGGGTGGGGGGGTCACCTTTTGCCTTGAAATGGGAAGTCAGTAGCCCCTTCCTCCTCCTCCCTCCTCCCCCTCC
TCTCTGGCAGGGATCTCAGATGACCGTGGCCTCCCTCTCAGAGGGGGAGAACGCCAGAGCCCTGGCTGGTGATGTGCTGGCTGGGGGTGA
ATCCCAATGAGGGTCCCTCTCAGAGCGGGAGAACGCCAGAGCCCTGGATGGTGATGCGCTGGCTGGGGGTGAATCCCAATGAGGGTCCCT
CTCAGAAAGGGAGAACGCCAGAGCCCTGGCTGGTGACATGCTGGCTGGGGGTGAATCCGAATGACAGTGCAGACGTTCTCCCATCCACCA
TGTCTGAGCTTGGGGGAATTGCCTCATTTCCCCTGGAAAAGAAACATGGTCCATTAGAGGGGAAAGCCCAGGGGTGAATCTTCACGCCCC
AAACAGTGCCCGGTGGGGAGGAGGCACCCGCTCCTTGTTGAGTAAAACCACCCATGGAGACTGGAACCTCATCTCCCTGGGTCGGGGGGT
GTTCAAGGCCACAGGACAAGGGGAGCACCCTGGGCCACACAGGCGTGGAGGTGTCCCCACCCCTTCCACCTGTCCCCCAGACCCAAAGCT
CTCTCCCCACCCTACCTGCCCACCTGGGGCTCCTGTGCCCCCTCCCCACTCCAGAGGCCACCCTACAAGTTGTCCTCAAGGTCATCCTGG
AGATGGGATCCAGGACGTGGGGCCATGACTCTCTGGGACCTTGCCACAGCCCCCATTCCCCTGCTTGCAGTCTGCAAGGACACCTTTGCA
GGGATTCTTGTCCTGCTGGCCACCCCACCCACACCTGTCCCTGGCCAGCAGGCCGCCTGCAAGCGTCAGGCACACAGGGACAGACATGGC
GAGCACAGTGCAGGCCCGGGGCCCACGGGCAACATGGAACCCTGGGAACTGCCCTCCCCCTTAGCTCACAGTGCCTGCGGTAGCCACTCT
AGGTCGTTGGCCTTCCTTGACCACTCCATTTAATTCTCTCTGCTGTTTGGGTTGGGTTTTTCCCCTTAGTTATCTGTGGGTTTCCTGTAT
TTTATGTTAATATTTCTATTAAGAACATGTTGGGCATGTGGACCCAAGCACCTGGGAAGGAGGTGGCATCTGAGACAGCCTGATACGTTC
CCGTCTGTGCACCCATGGAGATCCAGGCGTGGGCCCGTGTCTGTCCCTGGTTGTAAATTCGAGGGTCTGCATATCTGATGTTCAGGTAGA
CCTGGGCGCCTGGGAACGAGGCCATCAGCTGCCATGCACATAACAAAGAGACAATGCATTCCTTCTTATTTTTCCTTTTTAAAAATCGAT
GAATCATTTGTGATGCTTTTAACAAAGATTAAATGAATTTGATCAGC

>5863_5863_1_ARFGEF1-SORCS2_ARFGEF1_chr8_68255398_ENST00000262215_SORCS2_chr4_7398014_ENST00000507866_length(amino acids)=997AA_BP=
MILTKYYHADMGKVLESSLWRSSDFGTSYTKLTLQPGVTTVIDNFYICPTNKRKVILVSSSLSDRDQSLFLSADEGATFQKQPIPFFVET
LIFHPKEEDKVLAYTKESKLYVSSDLGKKWTLLQERVTKDHVFWSVSGVDADPDLVHVEAQDLGGDFRYVTCAIHNCSEKMLTAPFAGPI
DHGSLTVQDDYIFFKATSANQTKYYVSYRRNEFVLMKLPKYALPKDLQIISTDESQVFVAVQEWYQMDTYNLYQSDPRGVRYALVLQDVR
SSRQAEESVLIDILEVRGVKGVFLANQKIDGKVMTLITYNKGRDWDYLRPPSMDMNGKPTNCKPPDCHLHLHLRWADNPYVSGTVHTKDT
APGLIMGAGNLGSQLVEYKEEMYITSDCGHTWRQVFEEEHHILYLDHGGVIVAIKDTSIPLKILKFSVDEGLTWSTHNFTSTSVFVDGLL
SEPGDETLVMTVFGHISFRSDWELVKVDFRPSFSRQCGEEDYSSWELSNLQGDRCIMGQQRSFRKRKSTSWCIKGRSFTSALTSRVCECR
DSDFLCDYGFERSSSSESSTNKCSANFWFNPLSPPDDCALGQTYTSSLGYRKVVSNVCEGGVDMQQSQVQLQCPLTPPRGLQVSIQGEAV
AVRPGEDVLFVVRQEQGDVLTTKYQVDLGDGFKAMYVNLTLTGEPIRHRYESPGIYRVSVRAENTAGHDEAVLFVQVNSPLQALYLEVVP
VIGLNQEVNLTAVLLPLNPNLTVFYWWIGHSLQPLLSLDNSVTTRFSDTGDVRVTVQAACGNSVLQDSRVLRVLDQFQVMPLQFSKELDA
YNPNTPEWREDVGLVVTRLLSKETSVPQELLVTVVKPGLPTLADLYVLLPPPRPTRKRSLSSDKRLAAIQQVLNAQKISFLLRGGVRVLV
ALRDTGTGAEQLGGGGGYWAVVVLFVIGLFAAGAFILYKFKRKRPGRTVYAQMHNEKEQEMTSPVSHSEDVQGAVQGNHSGVVLSINSRE
MHSYLVS

--------------------------------------------------------------
>5863_5863_2_ARFGEF1-SORCS2_ARFGEF1_chr8_68255399_ENST00000262215_SORCS2_chr4_7398015_ENST00000507866_length(transcript)=6077nt_BP=514nt
GCGGTGCCTCTGAGAGCCGCCGCCACCTCGTCCCTCAGTTCCCGGCAGACAGCCGCCCGGGCCGGGCTCCCTCACCGCCACCAGGGCCGG
AGGGACGAGTGAGAGGGGCGGCCGGGACGCGACCCCCGGGCCGGGAGAAGCGGAGGCCCGACGGGCGCGGCCCTCGAGGTACGGCTTCTT
GGGGGCGGCGAGGACCTCGACGCCCTTCGCCGACACCGCGGCTGGTCCCGCTCGCCCGCCCCTTCCTGATCCTGCCGCTGCCCTCCACGC
CTCCAATCCCCCACCTCCACCCCCTCTCCTTTCTCTCTTCTCTTCCTTCCTCTCCTCCTCCTCCCCTCCAGCCGCTGGGAGCCGCGGGTC
GGACGAGCCGCCGCCTCCTTCTCTGCGTCCATGTATGAGGGGAAGAAGACGAAGAACATGTTCCTGACCCGGGCTCTGGAGAAGATATTG
GCCGACAAGGAAGTGAAGAAGGCGCATCACTCCCAGCTGCGCAAAGCTTGCGAGGTGGCGTTAGGTGATCTTGATCCTGACGAAGTACTA
CCACGCAGACATGGGGAAGGTTCTGGAAAGTTCTCTGTGGCGGTCATCAGATTTCGGGACGTCCTACACCAAGCTCACCCTCCAGCCTGG
TGTCACCACCGTCATCGACAATTTCTACATCTGCCCGACCAACAAGAGGAAGGTCATCCTTGTCAGCTCCTCACTCAGTGACCGGGACCA
GAGCCTATTCCTCAGCGCAGACGAAGGCGCCACCTTTCAGAAGCAGCCCATTCCCTTCTTCGTGGAAACTCTGATTTTCCACCCTAAGGA
GGAGGACAAGGTCCTCGCCTACACAAAGGAGAGCAAGCTCTACGTGTCATCTGACTTGGGGAAAAAGTGGACACTTCTGCAAGAGCGAGT
GACCAAAGACCACGTGTTCTGGTCTGTGTCTGGGGTGGACGCTGACCCTGACTTGGTCCACGTGGAAGCCCAAGACCTCGGTGGAGATTT
TCGGTACGTCACCTGCGCAATCCACAATTGCTCCGAGAAGATGCTGACAGCCCCATTCGCAGGCCCCATTGACCACGGGTCTCTGACCGT
GCAGGACGATTACATCTTCTTTAAGGCAACATCAGCAAACCAGACAAAATACTACGTCTCTTATCGTCGAAATGAATTTGTCCTGATGAA
GCTGCCGAAGTATGCATTGCCAAAGGATCTGCAGATCATCAGCACGGACGAGAGTCAGGTGTTCGTGGCGGTGCAGGAGTGGTACCAGAT
GGACACCTACAACCTGTACCAGTCGGACCCACGGGGCGTGCGCTACGCGCTGGTGCTGCAGGACGTGCGCAGCTCACGGCAGGCGGAGGA
GAGCGTGCTCATCGACATCCTGGAGGTCAGAGGGGTGAAAGGAGTCTTCCTGGCAAACCAAAAAATTGATGGGAAAGTGATGACGCTTAT
AACCTACAACAAGGGCCGCGACTGGGATTACCTGAGGCCACCCAGCATGGACATGAATGGAAAACCAACCAACTGCAAGCCTCCAGACTG
CCACCTGCACCTGCACCTGCGCTGGGCAGACAACCCCTACGTATCAGGCACCGTGCACACCAAGGACACCGCCCCAGGCCTCATCATGGG
TGCAGGTAACCTGGGCTCACAGCTGGTGGAATATAAAGAAGAAATGTACATCACGTCAGACTGTGGTCACACCTGGCGGCAGGTGTTTGA
GGAAGAGCATCACATCCTGTACCTGGACCACGGCGGCGTGATCGTGGCCATCAAAGACACCTCCATCCCTTTGAAGATCCTCAAGTTCAG
TGTGGACGAGGGCCTCACCTGGAGCACGCACAACTTCACCAGCACCTCGGTGTTTGTGGACGGGCTGCTGAGTGAGCCAGGGGACGAGAC
GCTGGTCATGACGGTCTTTGGCCACATCAGCTTCCGCTCCGATTGGGAGCTGGTCAAGGTGGACTTCCGGCCCTCATTCTCCAGGCAGTG
CGGCGAGGAGGACTACAGCTCCTGGGAGCTCTCCAACCTGCAGGGCGACCGCTGTATCATGGGCCAGCAGAGAAGTTTCCGGAAAAGAAA
GTCCACGTCCTGGTGCATCAAGGGGAGGAGCTTCACGTCGGCGCTCACGTCCCGCGTGTGCGAGTGCCGGGACTCGGACTTCCTGTGCGA
CTACGGATTTGAGCGCTCCTCCTCCTCAGAGTCCAGCACCAACAAGTGCTCTGCCAACTTCTGGTTTAACCCATTGTCCCCGCCTGACGA
CTGTGCCCTGGGCCAGACCTACACCAGCAGCCTTGGGTACCGGAAAGTGGTGTCCAACGTGTGTGAGGGTGGGGTGGACATGCAGCAGAG
TCAGGTGCAGCTGCAGTGCCCCCTCACGCCGCCCCGGGGCCTGCAGGTCAGCATTCAAGGCGAGGCGGTGGCCGTGCGGCCTGGAGAGGA
CGTCCTGTTTGTGGTGCGGCAGGAGCAGGGTGATGTCCTGACTACCAAGTACCAGGTAGACCTTGGGGACGGCTTCAAGGCCATGTACGT
GAACCTTACACTGACCGGGGAGCCCATCCGGCACCGCTACGAGAGCCCCGGCATCTACCGCGTGTCCGTCAGGGCAGAGAACACGGCAGG
CCACGATGAGGCGGTGCTCTTTGTCCAGGTCAACTCCCCCCTGCAGGCCCTCTACCTGGAGGTGGTTCCTGTCATTGGCCTCAACCAGGA
GGTGAACCTCACAGCTGTGCTGCTTCCCTTGAACCCTAACCTCACCGTCTTCTACTGGTGGATCGGCCACAGCCTGCAGCCCCTCCTTTC
CCTGGATAATTCTGTGACAACGCGGTTTTCGGACACGGGCGACGTGCGTGTGACGGTGCAGGCCGCCTGTGGGAACTCGGTGCTGCAGGA
CTCCAGGGTCCTCCGTGTGCTGGATCAATTTCAAGTCATGCCTCTGCAGTTTTCCAAGGAGCTGGATGCCTACAACCCCAACACCCCTGA
GTGGAGGGAAGACGTGGGCCTGGTGGTCACCCGGCTGCTCTCCAAGGAGACCAGCGTCCCTCAGGAGCTTCTGGTGACTGTGGTGAAGCC
GGGGCTGCCCACTTTGGCCGATCTGTACGTGCTCCTGCCCCCTCCCAGGCCCACAAGGAAGAGGAGCCTCTCGAGTGATAAGAGGCTCGC
CGCCATCCAGCAGGTGCTGAACGCACAGAAGATCAGCTTCCTCCTGCGAGGCGGAGTCCGGGTCCTGGTGGCCCTGCGGGACACAGGCAC
AGGTGCTGAGCAGCTGGGCGGCGGTGGCGGCTACTGGGCGGTAGTGGTGCTGTTTGTCATCGGGCTCTTCGCAGCGGGAGCCTTCATCCT
CTACAAGTTCAAAAGGAAACGGCCAGGCAGGACCGTGTACGCCCAAATGCACAACGAGAAGGAGCAGGAGATGACCAGCCCTGTGAGTCA
CAGTGAGGACGTCCAGGGCGCTGTCCAGGGCAACCACTCAGGCGTGGTCCTGAGCATCAACTCCCGAGAGATGCACAGCTACCTGGTGAG
CTGATGCCACCCCAGCATCTGTCTTTTCACCCACGGAGGGCACAGAACCACCAGCAAAGCCGGCGGCTGGACTGGCGCCCCTCAGAGACC
TGCGGAAAGCCCCCTCCCTGAGTCGTCGCCACACCAGGCGACAGGCACCACCCCCTCTGATAAATCCAAGCCCGCCCAGGCCCACGGGGG
GCCCACGGGACCCCCCGGGACTCCCCGGACATGGCCCTGCCCCTATGGGACACCAGGCCTGACTCAGGCAGGTTCTGCCCCCCAGACCCC
ACACACGGCCGCCCCACGTGCTGTCGCTCAGCCCGAGGCCTGACTTCTCTGGGCTGAGGCTGGTCGTCCTGGAGCCCTCCCAGTACCTCG
GGCTGCAAGAGCTGCAGACCCGTTCAGACACTGCGTTGCGGGCTCCTTCCCCGCAGAGGCCGGGGCCTCCCTGACTTTGCTTCTTCACTC
CCACCTGTGCGGCCACCCAGTCCCTCTGTGGGAGCCCGGGTGCCAGGCCCTCCCAACACCACACCACCCTCCAGGCCCCCCTGCCCTCCG
GCTGGAAACTGCAGCTCTGTAAATGCCTCTCTAGGTAGCTGCTGGCGGTGGTGGGGGTGTCTCACTCTCTGTCTTTATAGCCGGCGGTAG
CCACCGGGGTGGCTCTGTCAGAGTTCCGTACTCGGGAGCCCCTTTCCCTGAGTGCCCAGGGTGTCTCCTCTGCCCAGAGGGGCAGCAGCT
CTCCCTGGTTCTCCCCAGGGCAGACGGGGTAGGGCGGGCTCAGGACCCAGTGCCCATGGTTCCTCACTCCTACCAGCAAGCAGCACCATC
CCGCAGGCTTCTCCCACCTGATGGCTGTTCTCCCACCGGGTCTGGGCTCTGGAAGGAGCCAGATGCCCCCAGAAAGGTGGGTGGTGGAGA
CGGCACCAGATGTACCAGTTTTCTGCAGTTCCTTATAGGCGAAGGGAACCGGGTGGAAACCAAGCTGGGAGAGGCTGAGGATGGCAGGGC
TGGAAGGGCCATCAGCGTGACCCTCATTTTCAAGAAGGGGAAACTGAGGCCCAGGGAGGAGAGTAACTGAAGGTCACAGCACGGTCACAG
CAGAGGTGGCCGAACCCAGCCCTCTGCGCGCCAGTGCTGTGCGGTCTCCACACCCTTACGGTTTCCTAGAATCAGGGATGTTAGTGTAAG
TCTATAGGAATATAGGGGGGTGGGGGGGTCACCTTTTGCCTTGAAATGGGAAGTCAGTAGCCCCTTCCTCCTCCTCCCTCCTCCCCCTCC
TCTCTGGCAGGGATCTCAGATGACCGTGGCCTCCCTCTCAGAGGGGGAGAACGCCAGAGCCCTGGCTGGTGATGTGCTGGCTGGGGGTGA
ATCCCAATGAGGGTCCCTCTCAGAGCGGGAGAACGCCAGAGCCCTGGATGGTGATGCGCTGGCTGGGGGTGAATCCCAATGAGGGTCCCT
CTCAGAAAGGGAGAACGCCAGAGCCCTGGCTGGTGACATGCTGGCTGGGGGTGAATCCGAATGACAGTGCAGACGTTCTCCCATCCACCA
TGTCTGAGCTTGGGGGAATTGCCTCATTTCCCCTGGAAAAGAAACATGGTCCATTAGAGGGGAAAGCCCAGGGGTGAATCTTCACGCCCC
AAACAGTGCCCGGTGGGGAGGAGGCACCCGCTCCTTGTTGAGTAAAACCACCCATGGAGACTGGAACCTCATCTCCCTGGGTCGGGGGGT
GTTCAAGGCCACAGGACAAGGGGAGCACCCTGGGCCACACAGGCGTGGAGGTGTCCCCACCCCTTCCACCTGTCCCCCAGACCCAAAGCT
CTCTCCCCACCCTACCTGCCCACCTGGGGCTCCTGTGCCCCCTCCCCACTCCAGAGGCCACCCTACAAGTTGTCCTCAAGGTCATCCTGG
AGATGGGATCCAGGACGTGGGGCCATGACTCTCTGGGACCTTGCCACAGCCCCCATTCCCCTGCTTGCAGTCTGCAAGGACACCTTTGCA
GGGATTCTTGTCCTGCTGGCCACCCCACCCACACCTGTCCCTGGCCAGCAGGCCGCCTGCAAGCGTCAGGCACACAGGGACAGACATGGC
GAGCACAGTGCAGGCCCGGGGCCCACGGGCAACATGGAACCCTGGGAACTGCCCTCCCCCTTAGCTCACAGTGCCTGCGGTAGCCACTCT
AGGTCGTTGGCCTTCCTTGACCACTCCATTTAATTCTCTCTGCTGTTTGGGTTGGGTTTTTCCCCTTAGTTATCTGTGGGTTTCCTGTAT
TTTATGTTAATATTTCTATTAAGAACATGTTGGGCATGTGGACCCAAGCACCTGGGAAGGAGGTGGCATCTGAGACAGCCTGATACGTTC
CCGTCTGTGCACCCATGGAGATCCAGGCGTGGGCCCGTGTCTGTCCCTGGTTGTAAATTCGAGGGTCTGCATATCTGATGTTCAGGTAGA
CCTGGGCGCCTGGGAACGAGGCCATCAGCTGCCATGCACATAACAAAGAGACAATGCATTCCTTCTTATTTTTCCTTTTTAAAAATCGAT
GAATCATTTGTGATGCTTTTAACAAAGATTAAATGAATTTGATCAGC

>5863_5863_2_ARFGEF1-SORCS2_ARFGEF1_chr8_68255399_ENST00000262215_SORCS2_chr4_7398015_ENST00000507866_length(amino acids)=997AA_BP=
MILTKYYHADMGKVLESSLWRSSDFGTSYTKLTLQPGVTTVIDNFYICPTNKRKVILVSSSLSDRDQSLFLSADEGATFQKQPIPFFVET
LIFHPKEEDKVLAYTKESKLYVSSDLGKKWTLLQERVTKDHVFWSVSGVDADPDLVHVEAQDLGGDFRYVTCAIHNCSEKMLTAPFAGPI
DHGSLTVQDDYIFFKATSANQTKYYVSYRRNEFVLMKLPKYALPKDLQIISTDESQVFVAVQEWYQMDTYNLYQSDPRGVRYALVLQDVR
SSRQAEESVLIDILEVRGVKGVFLANQKIDGKVMTLITYNKGRDWDYLRPPSMDMNGKPTNCKPPDCHLHLHLRWADNPYVSGTVHTKDT
APGLIMGAGNLGSQLVEYKEEMYITSDCGHTWRQVFEEEHHILYLDHGGVIVAIKDTSIPLKILKFSVDEGLTWSTHNFTSTSVFVDGLL
SEPGDETLVMTVFGHISFRSDWELVKVDFRPSFSRQCGEEDYSSWELSNLQGDRCIMGQQRSFRKRKSTSWCIKGRSFTSALTSRVCECR
DSDFLCDYGFERSSSSESSTNKCSANFWFNPLSPPDDCALGQTYTSSLGYRKVVSNVCEGGVDMQQSQVQLQCPLTPPRGLQVSIQGEAV
AVRPGEDVLFVVRQEQGDVLTTKYQVDLGDGFKAMYVNLTLTGEPIRHRYESPGIYRVSVRAENTAGHDEAVLFVQVNSPLQALYLEVVP
VIGLNQEVNLTAVLLPLNPNLTVFYWWIGHSLQPLLSLDNSVTTRFSDTGDVRVTVQAACGNSVLQDSRVLRVLDQFQVMPLQFSKELDA
YNPNTPEWREDVGLVVTRLLSKETSVPQELLVTVVKPGLPTLADLYVLLPPPRPTRKRSLSSDKRLAAIQQVLNAQKISFLLRGGVRVLV
ALRDTGTGAEQLGGGGGYWAVVVLFVIGLFAAGAFILYKFKRKRPGRTVYAQMHNEKEQEMTSPVSHSEDVQGAVQGNHSGVVLSINSRE
MHSYLVS

--------------------------------------------------------------

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Fusion Gene PPI Analysis for ARFGEF1-SORCS2

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for ARFGEF1-SORCS2

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for ARFGEF1-SORCS2

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Tgene		C0005586	Bipolar Disorder	1	PSYGENET

Fusion Gene Studies in Kim Lab

Fusion gene:ARFGEF1-SORCS2 (FusionGDB2 ID:HG10565TG57537)

Fusion Gene Summary for ARFGEF1-SORCS2

Fusion Gene ORF analysis for ARFGEF1-SORCS2

Fusion Genomic Features for ARFGEF1-SORCS2

Fusion Protein Features for ARFGEF1-SORCS2

Fusion Gene Sequence for ARFGEF1-SORCS2

Fusion Gene PPI Analysis for ARFGEF1-SORCS2

Related Drugs for ARFGEF1-SORCS2

Related Diseases for ARFGEF1-SORCS2

Fusion Gene Studies
in Kim Lab